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Fusion gene ID: 27765 |
FusionGeneSummary for PLXNC1_CCDC41 |
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Fusion gene information | Fusion gene name: PLXNC1_CCDC41 | Fusion gene ID: 27765 | Hgene | Tgene | Gene symbol | PLXNC1 | CCDC41 | Gene ID | 10154 | 51134 |
Gene name | plexin C1 | centrosomal protein 83 | |
Synonyms | CD232|PLXN-C1|VESPR | CCDC41|NPHP18|NY-REN-58 | |
Cytomap | 12q22 | 12q22 | |
Type of gene | protein-coding | protein-coding | |
Description | plexin-C1plexin (semaphorin receptor)receptor for viral semaphorin proteinreceptor for virally-encoded semaphorinvirus-encoded semaphorin protein receptor | centrosomal protein of 83 kDaNY-REN-58 antigencoiled-coil domain-containing protein 41renal carcinoma antigen NY-REN-58 | |
Modification date | 20180523 | 20180519 | |
UniProtAcc | O60486 | ||
Ensembl transtripts involved in fusion gene | ENST00000258526, ENST00000547057, ENST00000551495, ENST00000545312, | ENST00000397809, ENST00000339839, ENST00000397807, ENST00000547575, ENST00000549352, | |
Fusion gene scores | * DoF score | 5 X 5 X 4=100 | 1 X 1 X 1=1 |
# samples | 6 | 1 | |
** MAII score | log2(6/100*10)=-0.736965594166206 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | log2(1/1*10)=3.32192809488736 | |
Context | PubMed: PLXNC1 [Title/Abstract] AND CCDC41 [Title/Abstract] AND fusion [Title/Abstract] | ||
Functional or gene categories assigned by FusionGDB annotation | Tumor suppressor gene involved fusion gene, in-frame but not retained their domain. |
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
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Partner | Gene | GO ID | GO term | PubMed ID |
![]() (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
TCGA | RV | SARC | TCGA-DX-A2IZ-01A | PLXNC1 | chr12 | 94659001 | + | CCDC41 | chr12 | 94706793 | - |
* LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
![]() * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
In-frame | ENST00000258526 | ENST00000397809 | PLXNC1 | chr12 | 94659001 | + | CCDC41 | chr12 | 94706793 | - |
In-frame | ENST00000258526 | ENST00000339839 | PLXNC1 | chr12 | 94659001 | + | CCDC41 | chr12 | 94706793 | - |
5CDS-intron | ENST00000258526 | ENST00000397807 | PLXNC1 | chr12 | 94659001 | + | CCDC41 | chr12 | 94706793 | - |
5CDS-intron | ENST00000258526 | ENST00000547575 | PLXNC1 | chr12 | 94659001 | + | CCDC41 | chr12 | 94706793 | - |
5CDS-intron | ENST00000258526 | ENST00000549352 | PLXNC1 | chr12 | 94659001 | + | CCDC41 | chr12 | 94706793 | - |
In-frame | ENST00000547057 | ENST00000397809 | PLXNC1 | chr12 | 94659001 | + | CCDC41 | chr12 | 94706793 | - |
In-frame | ENST00000547057 | ENST00000339839 | PLXNC1 | chr12 | 94659001 | + | CCDC41 | chr12 | 94706793 | - |
5CDS-intron | ENST00000547057 | ENST00000397807 | PLXNC1 | chr12 | 94659001 | + | CCDC41 | chr12 | 94706793 | - |
5CDS-intron | ENST00000547057 | ENST00000547575 | PLXNC1 | chr12 | 94659001 | + | CCDC41 | chr12 | 94706793 | - |
5CDS-intron | ENST00000547057 | ENST00000549352 | PLXNC1 | chr12 | 94659001 | + | CCDC41 | chr12 | 94706793 | - |
intron-3CDS | ENST00000551495 | ENST00000397809 | PLXNC1 | chr12 | 94659001 | + | CCDC41 | chr12 | 94706793 | - |
intron-3CDS | ENST00000551495 | ENST00000339839 | PLXNC1 | chr12 | 94659001 | + | CCDC41 | chr12 | 94706793 | - |
intron-intron | ENST00000551495 | ENST00000397807 | PLXNC1 | chr12 | 94659001 | + | CCDC41 | chr12 | 94706793 | - |
intron-intron | ENST00000551495 | ENST00000547575 | PLXNC1 | chr12 | 94659001 | + | CCDC41 | chr12 | 94706793 | - |
intron-intron | ENST00000551495 | ENST00000549352 | PLXNC1 | chr12 | 94659001 | + | CCDC41 | chr12 | 94706793 | - |
5UTR-3CDS | ENST00000545312 | ENST00000397809 | PLXNC1 | chr12 | 94659001 | + | CCDC41 | chr12 | 94706793 | - |
5UTR-3CDS | ENST00000545312 | ENST00000339839 | PLXNC1 | chr12 | 94659001 | + | CCDC41 | chr12 | 94706793 | - |
5UTR-intron | ENST00000545312 | ENST00000397807 | PLXNC1 | chr12 | 94659001 | + | CCDC41 | chr12 | 94706793 | - |
5UTR-intron | ENST00000545312 | ENST00000547575 | PLXNC1 | chr12 | 94659001 | + | CCDC41 | chr12 | 94706793 | - |
5UTR-intron | ENST00000545312 | ENST00000549352 | PLXNC1 | chr12 | 94659001 | + | CCDC41 | chr12 | 94706793 | - |
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FusionProtFeatures for PLXNC1_CCDC41 |
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Hgene | Tgene |
PLXNC1 | CCDC41 |
Receptor for SEMA7A, for smallpox semaphorin A39R,vaccinia virus semaphorin A39R and for herpesvirus Sema protein.Binding of semaphorins triggers cellular responses leading to therearrangement of the cytoskeleton and to secretion of IL6 and IL8(By similarity). {ECO:0000250, ECO:0000269|PubMed:20727575}. | Lectin that binds to various sugars: galactose > mannose= fucose > N-acetylglucosamine > N-acetylgalactosamine(PubMed:10224141). Acts as a chemoattractant, probably involved inthe regulation of cell migration (PubMed:28301481).{ECO:0000269|PubMed:10224141, ECO:0000269|PubMed:28301481}. |
![]() * Minus value of BPloci means that the break pointn is located before the CDS. |
- In-frame and retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
Hgene | PLXNC1 | chr12:94659001 | chr12:94706793 | ENST00000258526 | + | 21 | 31 | 35_452 | 1199 | 1569 | Domain | Sema |
Hgene | PLXNC1 | chr12:94659001 | chr12:94706793 | ENST00000258526 | + | 21 | 31 | 35_944 | 1199 | 1569 | Topological domain | Extracellular |
Hgene | PLXNC1 | chr12:94659001 | chr12:94706793 | ENST00000258526 | + | 21 | 31 | 945_965 | 1199 | 1569 | Transmembrane | Helical |
Tgene | >CCDC41 | chr12:94659001 | chr12:94706793 | ENST00000397807 | - | 0 | 14 | 40_634 | -211 | 569 | Coiled coil | Ontology_term=ECO:0000255 |
Tgene | >CCDC41 | chr12:94659001 | chr12:94706793 | ENST00000397807 | - | 0 | 14 | 665_698 | -211 | 569 | Coiled coil | Ontology_term=ECO:0000255 |
- In-frame and not-retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
Hgene | >PLXNC1 | chr12:94659001 | chr12:94706793 | ENST00000258526 | + | 21 | 31 | 966_1568 | 1199 | 1569 | Topological domain | Cytoplasmic |
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FusionGeneSequence for PLXNC1_CCDC41 |
![]() (nt: nucleotides, aa: amino acids) |
* Fusion amino acid sequences. |
* Fusion transcript sequences (only coding sequence (CDS) region). |
* Fusion transcript sequences (Full-length transcript). |
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FusionGenePPI for PLXNC1_CCDC41 |
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Hgene | Hgene's interactors | Tgene | Tgene's interactors |
PLXNC1 | CCDC41 |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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RelatedDrugs for PLXNC1_CCDC41 |
![]() (DrugBank Version 5.1.0 2018-04-02) |
Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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RelatedDiseases for PLXNC1_CCDC41 |
![]() (DisGeNet 4.0) |
Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
Hgene | PLXNC1 | C0014175 | Endometriosis | 1 | CTD_human |