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Fusion gene ID: 2775 |
FusionGeneSummary for ARMC9_SSR2 |
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Fusion gene information | Fusion gene name: ARMC9_SSR2 | Fusion gene ID: 2775 | Hgene | Tgene | Gene symbol | ARMC9 | SSR2 | Gene ID | 80210 | 6746 |
Gene name | armadillo repeat containing 9 | signal sequence receptor subunit 2 | |
Synonyms | ARM|JBTS30|KU-MEL-1|NS21 | HSD25|TLAP|TRAP-BETA|TRAPB | |
Cytomap | 2q37.1 | 1q22 | |
Type of gene | protein-coding | protein-coding | |
Description | lisH domain-containing protein ARMC9armadillo repeat-containing protein 9armadillo/beta-catenin-like repeatsmelanoma/melanocyte specific protein KU-MEL-1melanoma/melanocyte-specific tumor antigen KU-MEL-1 | translocon-associated protein subunit betaSSR-betasignal sequence receptor subunit betasignal sequence receptor, beta (translocon-associated protein beta)translocon-associated protein beta | |
Modification date | 20180519 | 20180523 | |
UniProtAcc | Q7Z3E5 | P43308 | |
Ensembl transtripts involved in fusion gene | ENST00000349938, ENST00000483477, | ENST00000295702, ENST00000529008, ENST00000496742, ENST00000480567, | |
Fusion gene scores | * DoF score | 8 X 6 X 6=288 | 6 X 7 X 4=168 |
# samples | 8 | 7 | |
** MAII score | log2(8/288*10)=-1.84799690655495 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | log2(7/168*10)=-1.26303440583379 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | |
Context | PubMed: ARMC9 [Title/Abstract] AND SSR2 [Title/Abstract] AND fusion [Title/Abstract] | ||
Functional or gene categories assigned by FusionGDB annotation |
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
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Partner | Gene | GO ID | GO term | PubMed ID |
![]() (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
TCGA | RV | PCPG | TCGA-WB-A81J-01A | ARMC9 | chr2 | 232160966 | + | SSR2 | chr1 | 155988159 | - |
* LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
![]() * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
Frame-shift | ENST00000349938 | ENST00000295702 | ARMC9 | chr2 | 232160966 | + | SSR2 | chr1 | 155988159 | - |
Frame-shift | ENST00000349938 | ENST00000529008 | ARMC9 | chr2 | 232160966 | + | SSR2 | chr1 | 155988159 | - |
5CDS-intron | ENST00000349938 | ENST00000496742 | ARMC9 | chr2 | 232160966 | + | SSR2 | chr1 | 155988159 | - |
5CDS-intron | ENST00000349938 | ENST00000480567 | ARMC9 | chr2 | 232160966 | + | SSR2 | chr1 | 155988159 | - |
3UTR-3CDS | ENST00000483477 | ENST00000295702 | ARMC9 | chr2 | 232160966 | + | SSR2 | chr1 | 155988159 | - |
3UTR-3CDS | ENST00000483477 | ENST00000529008 | ARMC9 | chr2 | 232160966 | + | SSR2 | chr1 | 155988159 | - |
3UTR-intron | ENST00000483477 | ENST00000496742 | ARMC9 | chr2 | 232160966 | + | SSR2 | chr1 | 155988159 | - |
3UTR-intron | ENST00000483477 | ENST00000480567 | ARMC9 | chr2 | 232160966 | + | SSR2 | chr1 | 155988159 | - |
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FusionProtFeatures for ARMC9_SSR2 |
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Hgene | Tgene |
ARMC9 | SSR2 |
Required for ciliogenesis.{ECO:0000250|UniProtKB:E7F187}. | TRAP proteins are part of a complex whose function is tobind calcium to the ER membrane and thereby regulate the retentionof ER resident proteins. |
![]() * Minus value of BPloci means that the break pointn is located before the CDS. |
- In-frame and retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
- In-frame and not-retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
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FusionGeneSequence for ARMC9_SSR2 |
![]() (nt: nucleotides, aa: amino acids) |
* Fusion amino acid sequences. |
* Fusion transcript sequences (only coding sequence (CDS) region). |
* Fusion transcript sequences (Full-length transcript). |
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FusionGenePPI for ARMC9_SSR2 |
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Hgene | Hgene's interactors | Tgene | Tgene's interactors |
ARMC9 | APP, CRTAP, CTSC, DPP8, NPLOC4, PRPS2, SIAH1, CMTM5, EPHA1 | SSR2 | SRPR, NXF1, RPN1, ATP1A1, UQCRC2 |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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RelatedDrugs for ARMC9_SSR2 |
![]() (DrugBank Version 5.1.0 2018-04-02) |
Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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RelatedDiseases for ARMC9_SSR2 |
![]() (DisGeNet 4.0) |
Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
Tgene | SSR2 | C0033578 | Prostatic Neoplasms | 1 | CTD_human |