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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 2775

FusionGeneSummary for ARMC9_SSR2

check button Fusion gene summary
Fusion gene informationFusion gene name: ARMC9_SSR2
Fusion gene ID: 2775
HgeneTgene
Gene symbol

ARMC9

SSR2

Gene ID

80210

6746

Gene namearmadillo repeat containing 9signal sequence receptor subunit 2
SynonymsARM|JBTS30|KU-MEL-1|NS21HSD25|TLAP|TRAP-BETA|TRAPB
Cytomap

2q37.1

1q22

Type of geneprotein-codingprotein-coding
DescriptionlisH domain-containing protein ARMC9armadillo repeat-containing protein 9armadillo/beta-catenin-like repeatsmelanoma/melanocyte specific protein KU-MEL-1melanoma/melanocyte-specific tumor antigen KU-MEL-1translocon-associated protein subunit betaSSR-betasignal sequence receptor subunit betasignal sequence receptor, beta (translocon-associated protein beta)translocon-associated protein beta
Modification date2018051920180523
UniProtAcc

Q7Z3E5

P43308

Ensembl transtripts involved in fusion geneENST00000349938, ENST00000483477, 
ENST00000295702, ENST00000529008, 
ENST00000496742, ENST00000480567, 
Fusion gene scores* DoF score8 X 6 X 6=2886 X 7 X 4=168
# samples 87
** MAII scorelog2(8/288*10)=-1.84799690655495
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
log2(7/168*10)=-1.26303440583379
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: ARMC9 [Title/Abstract] AND SSR2 [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID

check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
TCGARVPCPGTCGA-WB-A81J-01AARMC9chr2

232160966

+SSR2chr1

155988159

-
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
Frame-shitENST00000349938ENST00000295702ARMC9chr2

232160966

+SSR2chr1

155988159

-
Frame-shitENST00000349938ENST00000529008ARMC9chr2

232160966

+SSR2chr1

155988159

-
5CDS-intronENST00000349938ENST00000496742ARMC9chr2

232160966

+SSR2chr1

155988159

-
5CDS-intronENST00000349938ENST00000480567ARMC9chr2

232160966

+SSR2chr1

155988159

-
3UTR-3CDSENST00000483477ENST00000295702ARMC9chr2

232160966

+SSR2chr1

155988159

-
3UTR-3CDSENST00000483477ENST00000529008ARMC9chr2

232160966

+SSR2chr1

155988159

-
3UTR-intronENST00000483477ENST00000496742ARMC9chr2

232160966

+SSR2chr1

155988159

-
3UTR-intronENST00000483477ENST00000480567ARMC9chr2

232160966

+SSR2chr1

155988159

-

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FusionProtFeatures for ARMC9_SSR2


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
ARMC9

Q7Z3E5

SSR2

P43308

Required for ciliogenesis.{ECO:0000250|UniProtKB:E7F187}. TRAP proteins are part of a complex whose function is tobind calcium to the ER membrane and thereby regulate the retentionof ER resident proteins.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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FusionGeneSequence for ARMC9_SSR2


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for ARMC9_SSR2


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors
ARMC9APP, CRTAP, CTSC, DPP8, NPLOC4, PRPS2, SIAH1, CMTM5, EPHA1SSR2SRPR, NXF1, RPN1, ATP1A1, UQCRC2


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for ARMC9_SSR2


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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RelatedDiseases for ARMC9_SSR2


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
TgeneSSR2C0033578Prostatic Neoplasms1CTD_human