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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 27747

FusionGeneSummary for PLXNB1_ITIH3

check button Fusion gene summary
Fusion gene informationFusion gene name: PLXNB1_ITIH3
Fusion gene ID: 27747
HgeneTgene
Gene symbol

PLXNB1

ITIH3

Gene ID

5364

3699

Gene nameplexin B1inter-alpha-trypsin inhibitor heavy chain 3
SynonymsPLEXIN-B1|PLXN5|SEPH3P|ITI-HC3|SHAP
Cytomap

3p21.31

3p21.1

Type of geneprotein-codingprotein-coding
Descriptionplexin-B1plexin 5semaphorin receptor SEPinter-alpha-trypsin inhibitor heavy chain H3ITI heavy chain H3inter-alpha (globulin) inhibitor H3inter-alpha (globulin) inhibitor, H3 polypeptideinter-alpha-inhibitor heavy chain 3pre-alpha (globulin) inhibitor, H3 polypeptideserum-derived hyalurona
Modification date2018052320180519
UniProtAcc

O43157

Q06033

Ensembl transtripts involved in fusion geneENST00000296440, ENST00000358459, 
ENST00000358536, ENST00000448774, 
ENST00000456774, ENST00000465117, 
ENST00000416872, ENST00000449956, 
ENST00000465243, 
Fusion gene scores* DoF score7 X 8 X 5=2801 X 2 X 1=2
# samples 71
** MAII scorelog2(7/280*10)=-2
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(1/2*10)=2.32192809488736
Context

PubMed: PLXNB1 [Title/Abstract] AND ITIH3 [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgenePLXNB1

GO:0007162

negative regulation of cell adhesion

15218527

HgenePLXNB1

GO:0008360

regulation of cell shape

19843518

HgenePLXNB1

GO:0051493

regulation of cytoskeleton organization

19843518

HgenePLXNB1

GO:0071526

semaphorin-plexin signaling pathway

15218527|19843518


check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
TCGARVMESOTCGA-UD-AABY-01APLXNB1chr3

48463083

-ITIH3chr3

52838742

+
TCGALDMESOTCGA-UD-AABY-01APLXNB1chr3

48470662

-ITIH3chr3

52840119

+
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
5CDS-intronENST00000296440ENST00000416872PLXNB1chr3

48463083

-ITIH3chr3

52838742

+
5CDS-intronENST00000296440ENST00000449956PLXNB1chr3

48463083

-ITIH3chr3

52838742

+
5CDS-intronENST00000296440ENST00000465243PLXNB1chr3

48463083

-ITIH3chr3

52838742

+
5CDS-intronENST00000358459ENST00000416872PLXNB1chr3

48463083

-ITIH3chr3

52838742

+
5CDS-intronENST00000358459ENST00000449956PLXNB1chr3

48463083

-ITIH3chr3

52838742

+
5CDS-intronENST00000358459ENST00000465243PLXNB1chr3

48463083

-ITIH3chr3

52838742

+
5CDS-intronENST00000358536ENST00000416872PLXNB1chr3

48463083

-ITIH3chr3

52838742

+
5CDS-intronENST00000358536ENST00000449956PLXNB1chr3

48463083

-ITIH3chr3

52838742

+
5CDS-intronENST00000358536ENST00000465243PLXNB1chr3

48463083

-ITIH3chr3

52838742

+
intron-intronENST00000448774ENST00000416872PLXNB1chr3

48463083

-ITIH3chr3

52838742

+
intron-intronENST00000448774ENST00000449956PLXNB1chr3

48463083

-ITIH3chr3

52838742

+
intron-intronENST00000448774ENST00000465243PLXNB1chr3

48463083

-ITIH3chr3

52838742

+
5CDS-intronENST00000456774ENST00000416872PLXNB1chr3

48463083

-ITIH3chr3

52838742

+
5CDS-intronENST00000456774ENST00000449956PLXNB1chr3

48463083

-ITIH3chr3

52838742

+
5CDS-intronENST00000456774ENST00000465243PLXNB1chr3

48463083

-ITIH3chr3

52838742

+
intron-intronENST00000465117ENST00000416872PLXNB1chr3

48463083

-ITIH3chr3

52838742

+
intron-intronENST00000465117ENST00000449956PLXNB1chr3

48463083

-ITIH3chr3

52838742

+
intron-intronENST00000465117ENST00000465243PLXNB1chr3

48463083

-ITIH3chr3

52838742

+
intron-intronENST00000296440ENST00000416872PLXNB1chr3

48470662

-ITIH3chr3

52840119

+
intron-intronENST00000296440ENST00000449956PLXNB1chr3

48470662

-ITIH3chr3

52840119

+
intron-intronENST00000296440ENST00000465243PLXNB1chr3

48470662

-ITIH3chr3

52840119

+
5UTR-intronENST00000358459ENST00000416872PLXNB1chr3

48470662

-ITIH3chr3

52840119

+
5UTR-intronENST00000358459ENST00000449956PLXNB1chr3

48470662

-ITIH3chr3

52840119

+
5UTR-intronENST00000358459ENST00000465243PLXNB1chr3

48470662

-ITIH3chr3

52840119

+
5UTR-intronENST00000358536ENST00000416872PLXNB1chr3

48470662

-ITIH3chr3

52840119

+
5UTR-intronENST00000358536ENST00000449956PLXNB1chr3

48470662

-ITIH3chr3

52840119

+
5UTR-intronENST00000358536ENST00000465243PLXNB1chr3

48470662

-ITIH3chr3

52840119

+
intron-intronENST00000448774ENST00000416872PLXNB1chr3

48470662

-ITIH3chr3

52840119

+
intron-intronENST00000448774ENST00000449956PLXNB1chr3

48470662

-ITIH3chr3

52840119

+
intron-intronENST00000448774ENST00000465243PLXNB1chr3

48470662

-ITIH3chr3

52840119

+
intron-intronENST00000456774ENST00000416872PLXNB1chr3

48470662

-ITIH3chr3

52840119

+
intron-intronENST00000456774ENST00000449956PLXNB1chr3

48470662

-ITIH3chr3

52840119

+
intron-intronENST00000456774ENST00000465243PLXNB1chr3

48470662

-ITIH3chr3

52840119

+
intron-intronENST00000465117ENST00000416872PLXNB1chr3

48470662

-ITIH3chr3

52840119

+
intron-intronENST00000465117ENST00000449956PLXNB1chr3

48470662

-ITIH3chr3

52840119

+
intron-intronENST00000465117ENST00000465243PLXNB1chr3

48470662

-ITIH3chr3

52840119

+

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FusionProtFeatures for PLXNB1_ITIH3


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
PLXNB1

O43157

ITIH3

Q06033

Receptor for SEMA4D. Plays a role in RHOA activation andsubsequent changes of the actin cytoskeleton. Plays a role in axonguidance, invasive growth and cell migration.{ECO:0000269|PubMed:12196628, ECO:0000269|PubMed:12198496,ECO:0000269|PubMed:15210733, ECO:0000269|PubMed:19843518,ECO:0000269|PubMed:20877282, ECO:0000269|PubMed:21912513}. May act as a carrier of hyaluronan in serum or as abinding protein between hyaluronan and other matrix protein,including those on cell surfaces in tissues to regulate thelocalization, synthesis and degradation of hyaluronan which areessential to cells undergoing biological processes.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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FusionGeneSequence for PLXNB1_ITIH3


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for PLXNB1_ITIH3


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors
PLXNB1ARHGEF11, RND1, RND2, RND3, ARHGEF12, SEMA4D, RHOA, AKT1, GRB2, PLCG1, PLCG2, SOX4, DIAPH1, HNRNPD, SGTB, C21orf59, CENPO, CENPU, SMPX, HBB, HBA2ITIH3EP300, THTPA, NTF3, KCNA6, TGOLN2, CST7


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for PLXNB1_ITIH3


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status
TgeneITIH3Q06033DB01593ZincInter-alpha-trypsin inhibitor heavy chain H3small moleculeapproved|investigational

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RelatedDiseases for PLXNB1_ITIH3


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
TgeneITIH3C0005586Bipolar Disorder4PSYGENET
TgeneITIH3C0036341Schizophrenia1PSYGENET
TgeneITIH3C2239176Liver carcinoma1CTD_human