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Fusion gene ID: 27746 |
FusionGeneSummary for PLXNB1_HINT1 |
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Fusion gene information | Fusion gene name: PLXNB1_HINT1 | Fusion gene ID: 27746 | Hgene | Tgene | Gene symbol | PLXNB1 | HINT1 | Gene ID | 5364 | 3094 |
Gene name | plexin B1 | histidine triad nucleotide binding protein 1 | |
Synonyms | PLEXIN-B1|PLXN5|SEP | HINT|NMAN|PKCI-1|PRKCNH1 | |
Cytomap | 3p21.31 | 5q23.3 | |
Type of gene | protein-coding | protein-coding | |
Description | plexin-B1plexin 5semaphorin receptor SEP | histidine triad nucleotide-binding protein 1adenosine 5'-monophosphoramidaseprotein kinase C inhibitor 1protein kinase C-interacting protein 1 | |
Modification date | 20180523 | 20180519 | |
UniProtAcc | O43157 | P49773 | |
Ensembl transtripts involved in fusion gene | ENST00000296440, ENST00000358459, ENST00000358536, ENST00000448774, ENST00000456774, ENST00000465117, | ENST00000304043, ENST00000506207, ENST00000508488, ENST00000506908, ENST00000513012, | |
Fusion gene scores | * DoF score | 7 X 8 X 5=280 | 2 X 4 X 2=16 |
# samples | 7 | 4 | |
** MAII score | log2(7/280*10)=-2 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | log2(4/16*10)=1.32192809488736 effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs). DoF>8 and MAII>0 | |
Context | PubMed: PLXNB1 [Title/Abstract] AND HINT1 [Title/Abstract] AND fusion [Title/Abstract] | ||
Functional or gene categories assigned by FusionGDB annotation |
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
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Partner | Gene | GO ID | GO term | PubMed ID |
Hgene | PLXNB1 | GO:0007162 | negative regulation of cell adhesion | 15218527 |
Hgene | PLXNB1 | GO:0008360 | regulation of cell shape | 19843518 |
Hgene | PLXNB1 | GO:0051493 | regulation of cytoskeleton organization | 19843518 |
Hgene | PLXNB1 | GO:0071526 | semaphorin-plexin signaling pathway | 15218527|19843518 |
Tgene | HINT1 | GO:0009154 | purine ribonucleotide catabolic process | 16835243 |
![]() (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
TCGA | LD | BLCA | TCGA-E7-A5KE-01A | PLXNB1 | chr3 | 48450979 | - | HINT1 | chr5 | 130507426 | - |
* LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
![]() * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
5CDS-intron | ENST00000296440 | ENST00000304043 | PLXNB1 | chr3 | 48450979 | - | HINT1 | chr5 | 130507426 | - |
5CDS-intron | ENST00000296440 | ENST00000506207 | PLXNB1 | chr3 | 48450979 | - | HINT1 | chr5 | 130507426 | - |
5CDS-intron | ENST00000296440 | ENST00000508488 | PLXNB1 | chr3 | 48450979 | - | HINT1 | chr5 | 130507426 | - |
5CDS-intron | ENST00000296440 | ENST00000506908 | PLXNB1 | chr3 | 48450979 | - | HINT1 | chr5 | 130507426 | - |
5CDS-intron | ENST00000296440 | ENST00000513012 | PLXNB1 | chr3 | 48450979 | - | HINT1 | chr5 | 130507426 | - |
5CDS-intron | ENST00000358459 | ENST00000304043 | PLXNB1 | chr3 | 48450979 | - | HINT1 | chr5 | 130507426 | - |
5CDS-intron | ENST00000358459 | ENST00000506207 | PLXNB1 | chr3 | 48450979 | - | HINT1 | chr5 | 130507426 | - |
5CDS-intron | ENST00000358459 | ENST00000508488 | PLXNB1 | chr3 | 48450979 | - | HINT1 | chr5 | 130507426 | - |
5CDS-intron | ENST00000358459 | ENST00000506908 | PLXNB1 | chr3 | 48450979 | - | HINT1 | chr5 | 130507426 | - |
5CDS-intron | ENST00000358459 | ENST00000513012 | PLXNB1 | chr3 | 48450979 | - | HINT1 | chr5 | 130507426 | - |
5CDS-intron | ENST00000358536 | ENST00000304043 | PLXNB1 | chr3 | 48450979 | - | HINT1 | chr5 | 130507426 | - |
5CDS-intron | ENST00000358536 | ENST00000506207 | PLXNB1 | chr3 | 48450979 | - | HINT1 | chr5 | 130507426 | - |
5CDS-intron | ENST00000358536 | ENST00000508488 | PLXNB1 | chr3 | 48450979 | - | HINT1 | chr5 | 130507426 | - |
5CDS-intron | ENST00000358536 | ENST00000506908 | PLXNB1 | chr3 | 48450979 | - | HINT1 | chr5 | 130507426 | - |
5CDS-intron | ENST00000358536 | ENST00000513012 | PLXNB1 | chr3 | 48450979 | - | HINT1 | chr5 | 130507426 | - |
5CDS-intron | ENST00000448774 | ENST00000304043 | PLXNB1 | chr3 | 48450979 | - | HINT1 | chr5 | 130507426 | - |
5CDS-intron | ENST00000448774 | ENST00000506207 | PLXNB1 | chr3 | 48450979 | - | HINT1 | chr5 | 130507426 | - |
5CDS-intron | ENST00000448774 | ENST00000508488 | PLXNB1 | chr3 | 48450979 | - | HINT1 | chr5 | 130507426 | - |
5CDS-intron | ENST00000448774 | ENST00000506908 | PLXNB1 | chr3 | 48450979 | - | HINT1 | chr5 | 130507426 | - |
5CDS-intron | ENST00000448774 | ENST00000513012 | PLXNB1 | chr3 | 48450979 | - | HINT1 | chr5 | 130507426 | - |
5CDS-intron | ENST00000456774 | ENST00000304043 | PLXNB1 | chr3 | 48450979 | - | HINT1 | chr5 | 130507426 | - |
5CDS-intron | ENST00000456774 | ENST00000506207 | PLXNB1 | chr3 | 48450979 | - | HINT1 | chr5 | 130507426 | - |
5CDS-intron | ENST00000456774 | ENST00000508488 | PLXNB1 | chr3 | 48450979 | - | HINT1 | chr5 | 130507426 | - |
5CDS-intron | ENST00000456774 | ENST00000506908 | PLXNB1 | chr3 | 48450979 | - | HINT1 | chr5 | 130507426 | - |
5CDS-intron | ENST00000456774 | ENST00000513012 | PLXNB1 | chr3 | 48450979 | - | HINT1 | chr5 | 130507426 | - |
intron-intron | ENST00000465117 | ENST00000304043 | PLXNB1 | chr3 | 48450979 | - | HINT1 | chr5 | 130507426 | - |
intron-intron | ENST00000465117 | ENST00000506207 | PLXNB1 | chr3 | 48450979 | - | HINT1 | chr5 | 130507426 | - |
intron-intron | ENST00000465117 | ENST00000508488 | PLXNB1 | chr3 | 48450979 | - | HINT1 | chr5 | 130507426 | - |
intron-intron | ENST00000465117 | ENST00000506908 | PLXNB1 | chr3 | 48450979 | - | HINT1 | chr5 | 130507426 | - |
intron-intron | ENST00000465117 | ENST00000513012 | PLXNB1 | chr3 | 48450979 | - | HINT1 | chr5 | 130507426 | - |
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FusionProtFeatures for PLXNB1_HINT1 |
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Hgene | Tgene |
PLXNB1 | HINT1 |
Receptor for SEMA4D. Plays a role in RHOA activation andsubsequent changes of the actin cytoskeleton. Plays a role in axonguidance, invasive growth and cell migration.{ECO:0000269|PubMed:12196628, ECO:0000269|PubMed:12198496,ECO:0000269|PubMed:15210733, ECO:0000269|PubMed:19843518,ECO:0000269|PubMed:20877282, ECO:0000269|PubMed:21912513}. | Hydrolyzes purine nucleotide phosphoramidates with asingle phosphate group, including adenosine 5'monophosphoramidate(AMP-NH2), adenosine 5'monophosphomorpholidate (AMP-morpholidate)and guanosine 5'monophosphomorpholidate (GMP-morpholidate).Hydrolyzes lysyl-AMP (AMP-N-epsilon-(N-alpha-acetyl lysine methylester)) generated by lysine tRNA ligase, as well as Met-AMP, His-AMP and Asp-AMP, lysyl-GMP (GMP-N-epsilon-(N-alpha-acetyl lysinemethyl ester)) and AMP-N-alanine methyl ester. Can also convertadenosine 5'-O-phosphorothioate and guanosine 5'-O-phosphorothioate to the corresponding nucleoside 5'-O-phosphateswith concomitant release of hydrogen sulfide. In addition,functions as scaffolding protein that modulates transcriptionalactivation by the LEF1/TCF1-CTNNB1 complex and by the complexformed with MITF and CTNNB1. Modulates p53/TP53 levels andp53/TP53-mediated apoptosis. Modulates proteasomal degradation oftarget proteins by the SCF (SKP2-CUL1-F-box protein) E3 ubiquitin-protein ligase complex. {ECO:0000269|PubMed:15703176,ECO:0000269|PubMed:16014379, ECO:0000269|PubMed:16835243,ECO:0000269|PubMed:19112177, ECO:0000269|PubMed:22329685,ECO:0000269|PubMed:22647378, ECO:0000269|PubMed:9323207}. |
![]() * Minus value of BPloci means that the break pointn is located before the CDS. |
- In-frame and retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
- In-frame and not-retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
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FusionGeneSequence for PLXNB1_HINT1 |
![]() (nt: nucleotides, aa: amino acids) |
* Fusion amino acid sequences. |
* Fusion transcript sequences (only coding sequence (CDS) region). |
* Fusion transcript sequences (Full-length transcript). |
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FusionGenePPI for PLXNB1_HINT1 |
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Hgene | Hgene's interactors | Tgene | Tgene's interactors |
PLXNB1 | ARHGEF11, RND1, RND2, RND3, ARHGEF12, SEMA4D, RHOA, AKT1, GRB2, PLCG1, PLCG2, SOX4, DIAPH1, HNRNPD, SGTB, C21orf59, CENPO, CENPU, SMPX, HBB, HBA2 | HINT1 | KAT5, HINT1, MITF, CTNNB1, HDAC9, SIN3A, CDC34, RBX1, SP1, DHX36, RUVBL1, RUVBL2, LEF1, CDC16, HDAC7, ACTL6A, CDK9, UNK, AKR1B1, AKR1B10, AKR1B15, DUT, ENO1, ENO2, ENO3, FABP3, FABP5, FABP7, FKBP1A, FKBP1B, FKBP2, GPX4, GSTO2, GSTT1, ARHGDIA, FKBP7, HSPA4L, MTAP, NUTF2, OXCT1, PFDN2, PIN1, PTGR1, RAE1, RGN, SPR, TKT, TXN, UCHL3, HSPE1, MIF, NME1-NME2, NME2, PARK7, PMP2, PPIB, PRDX2, PRDX5, PRDX6, STIP1, TAGLN, TAGLN2, TAGLN3, UBE2V1, TMEM189-UBE2V1, UFC1, EWSR1, OFD1, SCLT1, STIL, BTRC, U2AF2, SNX24, SNRNP27, GNL1, SOD1, TRIM25 |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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RelatedDrugs for PLXNB1_HINT1 |
![]() (DrugBank Version 5.1.0 2018-04-02) |
Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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RelatedDiseases for PLXNB1_HINT1 |
![]() (DisGeNet 4.0) |
Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
Tgene | HINT1 | C0036341 | Schizophrenia | 2 | CTD_human |
Tgene | HINT1 | C0005586 | Bipolar Disorder | 1 | PSYGENET |
Tgene | HINT1 | C0026848 | Myopathy | 1 | CTD_human |
Tgene | HINT1 | C0242287 | Isaacs syndrome | 1 | ORPHANET;UNIPROT |
Tgene | HINT1 | C1861063 | TOBACCO ADDICTION, SUSCEPTIBILITY TO (finding) | 1 | CTD_human |
Tgene | HINT1 | C2932678 | Inherited Peripheral Neuropathy | 1 | CTD_human |