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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 27746

FusionGeneSummary for PLXNB1_HINT1

check button Fusion gene summary
Fusion gene informationFusion gene name: PLXNB1_HINT1
Fusion gene ID: 27746
HgeneTgene
Gene symbol

PLXNB1

HINT1

Gene ID

5364

3094

Gene nameplexin B1histidine triad nucleotide binding protein 1
SynonymsPLEXIN-B1|PLXN5|SEPHINT|NMAN|PKCI-1|PRKCNH1
Cytomap

3p21.31

5q23.3

Type of geneprotein-codingprotein-coding
Descriptionplexin-B1plexin 5semaphorin receptor SEPhistidine triad nucleotide-binding protein 1adenosine 5'-monophosphoramidaseprotein kinase C inhibitor 1protein kinase C-interacting protein 1
Modification date2018052320180519
UniProtAcc

O43157

P49773

Ensembl transtripts involved in fusion geneENST00000296440, ENST00000358459, 
ENST00000358536, ENST00000448774, 
ENST00000456774, ENST00000465117, 
ENST00000304043, ENST00000506207, 
ENST00000508488, ENST00000506908, 
ENST00000513012, 
Fusion gene scores* DoF score7 X 8 X 5=2802 X 4 X 2=16
# samples 74
** MAII scorelog2(7/280*10)=-2
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
log2(4/16*10)=1.32192809488736
effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs).
DoF>8 and MAII>0
Context

PubMed: PLXNB1 [Title/Abstract] AND HINT1 [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgenePLXNB1

GO:0007162

negative regulation of cell adhesion

15218527

HgenePLXNB1

GO:0008360

regulation of cell shape

19843518

HgenePLXNB1

GO:0051493

regulation of cytoskeleton organization

19843518

HgenePLXNB1

GO:0071526

semaphorin-plexin signaling pathway

15218527|19843518

TgeneHINT1

GO:0009154

purine ribonucleotide catabolic process

16835243


check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
TCGALDBLCATCGA-E7-A5KE-01APLXNB1chr3

48450979

-HINT1chr5

130507426

-
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
5CDS-intronENST00000296440ENST00000304043PLXNB1chr3

48450979

-HINT1chr5

130507426

-
5CDS-intronENST00000296440ENST00000506207PLXNB1chr3

48450979

-HINT1chr5

130507426

-
5CDS-intronENST00000296440ENST00000508488PLXNB1chr3

48450979

-HINT1chr5

130507426

-
5CDS-intronENST00000296440ENST00000506908PLXNB1chr3

48450979

-HINT1chr5

130507426

-
5CDS-intronENST00000296440ENST00000513012PLXNB1chr3

48450979

-HINT1chr5

130507426

-
5CDS-intronENST00000358459ENST00000304043PLXNB1chr3

48450979

-HINT1chr5

130507426

-
5CDS-intronENST00000358459ENST00000506207PLXNB1chr3

48450979

-HINT1chr5

130507426

-
5CDS-intronENST00000358459ENST00000508488PLXNB1chr3

48450979

-HINT1chr5

130507426

-
5CDS-intronENST00000358459ENST00000506908PLXNB1chr3

48450979

-HINT1chr5

130507426

-
5CDS-intronENST00000358459ENST00000513012PLXNB1chr3

48450979

-HINT1chr5

130507426

-
5CDS-intronENST00000358536ENST00000304043PLXNB1chr3

48450979

-HINT1chr5

130507426

-
5CDS-intronENST00000358536ENST00000506207PLXNB1chr3

48450979

-HINT1chr5

130507426

-
5CDS-intronENST00000358536ENST00000508488PLXNB1chr3

48450979

-HINT1chr5

130507426

-
5CDS-intronENST00000358536ENST00000506908PLXNB1chr3

48450979

-HINT1chr5

130507426

-
5CDS-intronENST00000358536ENST00000513012PLXNB1chr3

48450979

-HINT1chr5

130507426

-
5CDS-intronENST00000448774ENST00000304043PLXNB1chr3

48450979

-HINT1chr5

130507426

-
5CDS-intronENST00000448774ENST00000506207PLXNB1chr3

48450979

-HINT1chr5

130507426

-
5CDS-intronENST00000448774ENST00000508488PLXNB1chr3

48450979

-HINT1chr5

130507426

-
5CDS-intronENST00000448774ENST00000506908PLXNB1chr3

48450979

-HINT1chr5

130507426

-
5CDS-intronENST00000448774ENST00000513012PLXNB1chr3

48450979

-HINT1chr5

130507426

-
5CDS-intronENST00000456774ENST00000304043PLXNB1chr3

48450979

-HINT1chr5

130507426

-
5CDS-intronENST00000456774ENST00000506207PLXNB1chr3

48450979

-HINT1chr5

130507426

-
5CDS-intronENST00000456774ENST00000508488PLXNB1chr3

48450979

-HINT1chr5

130507426

-
5CDS-intronENST00000456774ENST00000506908PLXNB1chr3

48450979

-HINT1chr5

130507426

-
5CDS-intronENST00000456774ENST00000513012PLXNB1chr3

48450979

-HINT1chr5

130507426

-
intron-intronENST00000465117ENST00000304043PLXNB1chr3

48450979

-HINT1chr5

130507426

-
intron-intronENST00000465117ENST00000506207PLXNB1chr3

48450979

-HINT1chr5

130507426

-
intron-intronENST00000465117ENST00000508488PLXNB1chr3

48450979

-HINT1chr5

130507426

-
intron-intronENST00000465117ENST00000506908PLXNB1chr3

48450979

-HINT1chr5

130507426

-
intron-intronENST00000465117ENST00000513012PLXNB1chr3

48450979

-HINT1chr5

130507426

-

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FusionProtFeatures for PLXNB1_HINT1


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
PLXNB1

O43157

HINT1

P49773

Receptor for SEMA4D. Plays a role in RHOA activation andsubsequent changes of the actin cytoskeleton. Plays a role in axonguidance, invasive growth and cell migration.{ECO:0000269|PubMed:12196628, ECO:0000269|PubMed:12198496,ECO:0000269|PubMed:15210733, ECO:0000269|PubMed:19843518,ECO:0000269|PubMed:20877282, ECO:0000269|PubMed:21912513}. Hydrolyzes purine nucleotide phosphoramidates with asingle phosphate group, including adenosine 5'monophosphoramidate(AMP-NH2), adenosine 5'monophosphomorpholidate (AMP-morpholidate)and guanosine 5'monophosphomorpholidate (GMP-morpholidate).Hydrolyzes lysyl-AMP (AMP-N-epsilon-(N-alpha-acetyl lysine methylester)) generated by lysine tRNA ligase, as well as Met-AMP, His-AMP and Asp-AMP, lysyl-GMP (GMP-N-epsilon-(N-alpha-acetyl lysinemethyl ester)) and AMP-N-alanine methyl ester. Can also convertadenosine 5'-O-phosphorothioate and guanosine 5'-O-phosphorothioate to the corresponding nucleoside 5'-O-phosphateswith concomitant release of hydrogen sulfide. In addition,functions as scaffolding protein that modulates transcriptionalactivation by the LEF1/TCF1-CTNNB1 complex and by the complexformed with MITF and CTNNB1. Modulates p53/TP53 levels andp53/TP53-mediated apoptosis. Modulates proteasomal degradation oftarget proteins by the SCF (SKP2-CUL1-F-box protein) E3 ubiquitin-protein ligase complex. {ECO:0000269|PubMed:15703176,ECO:0000269|PubMed:16014379, ECO:0000269|PubMed:16835243,ECO:0000269|PubMed:19112177, ECO:0000269|PubMed:22329685,ECO:0000269|PubMed:22647378, ECO:0000269|PubMed:9323207}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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FusionGeneSequence for PLXNB1_HINT1


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for PLXNB1_HINT1


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors
PLXNB1ARHGEF11, RND1, RND2, RND3, ARHGEF12, SEMA4D, RHOA, AKT1, GRB2, PLCG1, PLCG2, SOX4, DIAPH1, HNRNPD, SGTB, C21orf59, CENPO, CENPU, SMPX, HBB, HBA2HINT1KAT5, HINT1, MITF, CTNNB1, HDAC9, SIN3A, CDC34, RBX1, SP1, DHX36, RUVBL1, RUVBL2, LEF1, CDC16, HDAC7, ACTL6A, CDK9, UNK, AKR1B1, AKR1B10, AKR1B15, DUT, ENO1, ENO2, ENO3, FABP3, FABP5, FABP7, FKBP1A, FKBP1B, FKBP2, GPX4, GSTO2, GSTT1, ARHGDIA, FKBP7, HSPA4L, MTAP, NUTF2, OXCT1, PFDN2, PIN1, PTGR1, RAE1, RGN, SPR, TKT, TXN, UCHL3, HSPE1, MIF, NME1-NME2, NME2, PARK7, PMP2, PPIB, PRDX2, PRDX5, PRDX6, STIP1, TAGLN, TAGLN2, TAGLN3, UBE2V1, TMEM189-UBE2V1, UFC1, EWSR1, OFD1, SCLT1, STIL, BTRC, U2AF2, SNX24, SNRNP27, GNL1, SOD1, TRIM25


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for PLXNB1_HINT1


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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RelatedDiseases for PLXNB1_HINT1


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
TgeneHINT1C0036341Schizophrenia2CTD_human
TgeneHINT1C0005586Bipolar Disorder1PSYGENET
TgeneHINT1C0026848Myopathy1CTD_human
TgeneHINT1C0242287Isaacs syndrome1ORPHANET;UNIPROT
TgeneHINT1C1861063TOBACCO ADDICTION, SUSCEPTIBILITY TO (finding)1CTD_human
TgeneHINT1C2932678Inherited Peripheral Neuropathy1CTD_human