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Fusion gene ID: 27745 |
FusionGeneSummary for PLXNB1_COL7A1 |
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Fusion gene information | Fusion gene name: PLXNB1_COL7A1 | Fusion gene ID: 27745 | Hgene | Tgene | Gene symbol | PLXNB1 | COL7A1 | Gene ID | 5364 | 1294 |
Gene name | plexin B1 | collagen type VII alpha 1 chain | |
Synonyms | PLEXIN-B1|PLXN5|SEP | EBD1|EBDCT|EBR1|NDNC8 | |
Cytomap | 3p21.31 | 3p21.31 | |
Type of gene | protein-coding | protein-coding | |
Description | plexin-B1plexin 5semaphorin receptor SEP | collagen alpha-1(VII) chainLC collagencollagen VII, alpha-1 polypeptidecollagen, type VII, alpha 1long-chain collagen | |
Modification date | 20180523 | 20180523 | |
UniProtAcc | O43157 | Q02388 | |
Ensembl transtripts involved in fusion gene | ENST00000296440, ENST00000358459, ENST00000358536, ENST00000448774, ENST00000456774, ENST00000465117, | ENST00000454817, ENST00000328333, ENST00000470076, | |
Fusion gene scores | * DoF score | 7 X 8 X 5=280 | 4 X 4 X 3=48 |
# samples | 7 | 4 | |
** MAII score | log2(7/280*10)=-2 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | log2(4/48*10)=-0.263034405833794 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | |
Context | PubMed: PLXNB1 [Title/Abstract] AND COL7A1 [Title/Abstract] AND fusion [Title/Abstract] | ||
Functional or gene categories assigned by FusionGDB annotation |
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
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Partner | Gene | GO ID | GO term | PubMed ID |
Hgene | PLXNB1 | GO:0007162 | negative regulation of cell adhesion | 15218527 |
Hgene | PLXNB1 | GO:0008360 | regulation of cell shape | 19843518 |
Hgene | PLXNB1 | GO:0051493 | regulation of cytoskeleton organization | 19843518 |
Hgene | PLXNB1 | GO:0071526 | semaphorin-plexin signaling pathway | 15218527|19843518 |
![]() (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
TCGA | LD | OV | TCGA-25-2397-01A | PLXNB1 | chr3 | 48454606 | - | COL7A1 | chr3 | 48625365 | - |
* LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
![]() * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
intron-3CDS | ENST00000296440 | ENST00000454817 | PLXNB1 | chr3 | 48454606 | - | COL7A1 | chr3 | 48625365 | - |
intron-3CDS | ENST00000296440 | ENST00000328333 | PLXNB1 | chr3 | 48454606 | - | COL7A1 | chr3 | 48625365 | - |
intron-intron | ENST00000296440 | ENST00000470076 | PLXNB1 | chr3 | 48454606 | - | COL7A1 | chr3 | 48625365 | - |
intron-3CDS | ENST00000358459 | ENST00000454817 | PLXNB1 | chr3 | 48454606 | - | COL7A1 | chr3 | 48625365 | - |
intron-3CDS | ENST00000358459 | ENST00000328333 | PLXNB1 | chr3 | 48454606 | - | COL7A1 | chr3 | 48625365 | - |
intron-intron | ENST00000358459 | ENST00000470076 | PLXNB1 | chr3 | 48454606 | - | COL7A1 | chr3 | 48625365 | - |
intron-3CDS | ENST00000358536 | ENST00000454817 | PLXNB1 | chr3 | 48454606 | - | COL7A1 | chr3 | 48625365 | - |
intron-3CDS | ENST00000358536 | ENST00000328333 | PLXNB1 | chr3 | 48454606 | - | COL7A1 | chr3 | 48625365 | - |
intron-intron | ENST00000358536 | ENST00000470076 | PLXNB1 | chr3 | 48454606 | - | COL7A1 | chr3 | 48625365 | - |
intron-3CDS | ENST00000448774 | ENST00000454817 | PLXNB1 | chr3 | 48454606 | - | COL7A1 | chr3 | 48625365 | - |
intron-3CDS | ENST00000448774 | ENST00000328333 | PLXNB1 | chr3 | 48454606 | - | COL7A1 | chr3 | 48625365 | - |
intron-intron | ENST00000448774 | ENST00000470076 | PLXNB1 | chr3 | 48454606 | - | COL7A1 | chr3 | 48625365 | - |
intron-3CDS | ENST00000456774 | ENST00000454817 | PLXNB1 | chr3 | 48454606 | - | COL7A1 | chr3 | 48625365 | - |
intron-3CDS | ENST00000456774 | ENST00000328333 | PLXNB1 | chr3 | 48454606 | - | COL7A1 | chr3 | 48625365 | - |
intron-intron | ENST00000456774 | ENST00000470076 | PLXNB1 | chr3 | 48454606 | - | COL7A1 | chr3 | 48625365 | - |
intron-3CDS | ENST00000465117 | ENST00000454817 | PLXNB1 | chr3 | 48454606 | - | COL7A1 | chr3 | 48625365 | - |
intron-3CDS | ENST00000465117 | ENST00000328333 | PLXNB1 | chr3 | 48454606 | - | COL7A1 | chr3 | 48625365 | - |
intron-intron | ENST00000465117 | ENST00000470076 | PLXNB1 | chr3 | 48454606 | - | COL7A1 | chr3 | 48625365 | - |
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FusionProtFeatures for PLXNB1_COL7A1 |
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Hgene | Tgene |
PLXNB1 | COL7A1 |
Receptor for SEMA4D. Plays a role in RHOA activation andsubsequent changes of the actin cytoskeleton. Plays a role in axonguidance, invasive growth and cell migration.{ECO:0000269|PubMed:12196628, ECO:0000269|PubMed:12198496,ECO:0000269|PubMed:15210733, ECO:0000269|PubMed:19843518,ECO:0000269|PubMed:20877282, ECO:0000269|PubMed:21912513}. | Stratified squamous epithelial basement membrane proteinthat forms anchoring fibrils which may contribute to epithelialbasement membrane organization and adherence by interacting withextracellular matrix (ECM) proteins such as type IV collagen. |
![]() * Minus value of BPloci means that the break pointn is located before the CDS. |
- In-frame and retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
- In-frame and not-retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
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FusionGeneSequence for PLXNB1_COL7A1 |
![]() (nt: nucleotides, aa: amino acids) |
* Fusion amino acid sequences. |
* Fusion transcript sequences (only coding sequence (CDS) region). |
* Fusion transcript sequences (Full-length transcript). |
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FusionGenePPI for PLXNB1_COL7A1 |
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Hgene | Hgene's interactors | Tgene | Tgene's interactors |
PLXNB1 | ARHGEF11, RND1, RND2, RND3, ARHGEF12, SEMA4D, RHOA, AKT1, GRB2, PLCG1, PLCG2, SOX4, DIAPH1, HNRNPD, SGTB, C21orf59, CENPO, CENPU, SMPX, HBB, HBA2 | COL7A1 | FN1, LAMA5, COL1A1, COL4A1, LAMB3, LAMC2, THBS1, LRRC57, MOV10, NXF1, NFKBIA, SNCA |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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RelatedDrugs for PLXNB1_COL7A1 |
![]() (DrugBank Version 5.1.0 2018-04-02) |
Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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RelatedDiseases for PLXNB1_COL7A1 |
![]() (DisGeNet 4.0) |
Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
Tgene | COL7A1 | C0079474 | Hallopeau-Siemens Disease | 16 | ORPHANET;UNIPROT |
Tgene | COL7A1 | C0432322 | Dominant dystrophic epidermolysis bullosa, albopapular type (disorder) | 15 | CTD_human;ORPHANET;UNIPROT |
Tgene | COL7A1 | C1851573 | Transient bullous dermolysis of the newborn | 2 | CTD_human;ORPHANET;UNIPROT |
Tgene | COL7A1 | C0009404 | Colorectal Neoplasms | 1 | CTD_human |
Tgene | COL7A1 | C0432321 | Epidermolysis bullosa, pretibial | 1 | CTD_human;HPO;ORPHANET;UNIPROT |
Tgene | COL7A1 | C1275114 | Epidermolysis Bullosa Pruriginosa | 1 | CTD_human;ORPHANET;UNIPROT |
Tgene | COL7A1 | C1458155 | Mammary Neoplasms | 1 | CTD_human |
Tgene | COL7A1 | C1843761 | TOENAIL DYSTROPHY, ISOLATED | 1 | CTD_human;UNIPROT |