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Fusion gene ID: 27733 |
FusionGeneSummary for PLXNA1_TNK2 |
 Fusion gene summary |
| Fusion gene information | Fusion gene name: PLXNA1_TNK2 | Fusion gene ID: 27733 | Hgene | Tgene | Gene symbol | PLXNA1 | TNK2 | Gene ID | 5361 | 10188 |
| Gene name | plexin A1 | tyrosine kinase non receptor 2 | |
| Synonyms | NOV|NOVP|PLEXIN-A1|PLXN1 | ACK|ACK-1|ACK1|p21cdc42Hs | |
| Cytomap | 3q21.3 | 3q29 | |
| Type of gene | protein-coding | protein-coding | |
| Description | plexin-A1plexin 1semaphorin receptor NOV | activated CDC42 kinase 1activated Cdc42-associated kinase 1activated p21cdc42Hs kinasetyrosine kinase non-receptor protein 2 | |
| Modification date | 20180523 | 20180523 | |
| UniProtAcc | Q9UIW2 | Q07912 | |
| Ensembl transtripts involved in fusion gene | ENST00000393409, ENST00000251772, ENST00000505278, | ENST00000381916, ENST00000333602, ENST00000428187, ENST00000392400, ENST00000316664, ENST00000468819, | |
| Fusion gene scores | * DoF score | 4 X 3 X 4=48 | 3 X 3 X 3=27 |
| # samples | 6 | 4 | |
| ** MAII score | log2(6/48*10)=0.321928094887362 effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs). DoF>8 and MAII>0 | log2(4/27*10)=0.567040592723894 effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs). DoF>8 and MAII>0 | |
| Context | PubMed: PLXNA1 [Title/Abstract] AND TNK2 [Title/Abstract] AND fusion [Title/Abstract] | ||
| Functional or gene categories assigned by FusionGDB annotation | Kinase involved fusion gene, inframe and retained kinase domain. | ||
| * DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
| Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Partner | Gene | GO ID | GO term | PubMed ID |
| Tgene | TNK2 | GO:0016310 | phosphorylation | 20333297|20979614 |
| Tgene | TNK2 | GO:0050731 | positive regulation of peptidyl-tyrosine phosphorylation | 10587647 |
| Tgene | TNK2 | GO:2000369 | regulation of clathrin-dependent endocytosis | 18262180 |
| Fusion gene information from three resources (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| TCGA | LD | SKCM | TCGA-D9-A6EA-06A | PLXNA1 | chr3 | 126710409 | + | TNK2 | chr3 | 195615477 | - |
| TCGA | LD | SKCM | TCGA-EE-A2A1-06A | PLXNA1 | chr3 | 126710409 | + | TNK2 | chr3 | 195615477 | - |
| * LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
| Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| In-frame | ENST00000393409 | ENST00000381916 | PLXNA1 | chr3 | 126710409 | + | TNK2 | chr3 | 195615477 | - |
| 5CDS-5UTR | ENST00000393409 | ENST00000333602 | PLXNA1 | chr3 | 126710409 | + | TNK2 | chr3 | 195615477 | - |
| 5CDS-5UTR | ENST00000393409 | ENST00000428187 | PLXNA1 | chr3 | 126710409 | + | TNK2 | chr3 | 195615477 | - |
| 5CDS-5UTR | ENST00000393409 | ENST00000392400 | PLXNA1 | chr3 | 126710409 | + | TNK2 | chr3 | 195615477 | - |
| 5CDS-5UTR | ENST00000393409 | ENST00000316664 | PLXNA1 | chr3 | 126710409 | + | TNK2 | chr3 | 195615477 | - |
| 5CDS-5UTR | ENST00000393409 | ENST00000468819 | PLXNA1 | chr3 | 126710409 | + | TNK2 | chr3 | 195615477 | - |
| In-frame | ENST00000251772 | ENST00000381916 | PLXNA1 | chr3 | 126710409 | + | TNK2 | chr3 | 195615477 | - |
| 5CDS-5UTR | ENST00000251772 | ENST00000333602 | PLXNA1 | chr3 | 126710409 | + | TNK2 | chr3 | 195615477 | - |
| 5CDS-5UTR | ENST00000251772 | ENST00000428187 | PLXNA1 | chr3 | 126710409 | + | TNK2 | chr3 | 195615477 | - |
| 5CDS-5UTR | ENST00000251772 | ENST00000392400 | PLXNA1 | chr3 | 126710409 | + | TNK2 | chr3 | 195615477 | - |
| 5CDS-5UTR | ENST00000251772 | ENST00000316664 | PLXNA1 | chr3 | 126710409 | + | TNK2 | chr3 | 195615477 | - |
| 5CDS-5UTR | ENST00000251772 | ENST00000468819 | PLXNA1 | chr3 | 126710409 | + | TNK2 | chr3 | 195615477 | - |
| intron-3CDS | ENST00000505278 | ENST00000381916 | PLXNA1 | chr3 | 126710409 | + | TNK2 | chr3 | 195615477 | - |
| intron-5UTR | ENST00000505278 | ENST00000333602 | PLXNA1 | chr3 | 126710409 | + | TNK2 | chr3 | 195615477 | - |
| intron-5UTR | ENST00000505278 | ENST00000428187 | PLXNA1 | chr3 | 126710409 | + | TNK2 | chr3 | 195615477 | - |
| intron-5UTR | ENST00000505278 | ENST00000392400 | PLXNA1 | chr3 | 126710409 | + | TNK2 | chr3 | 195615477 | - |
| intron-5UTR | ENST00000505278 | ENST00000316664 | PLXNA1 | chr3 | 126710409 | + | TNK2 | chr3 | 195615477 | - |
| intron-5UTR | ENST00000505278 | ENST00000468819 | PLXNA1 | chr3 | 126710409 | + | TNK2 | chr3 | 195615477 | - |
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FusionProtFeatures for PLXNA1_TNK2 |
| Main function of each fusion partner protein. (from UniProt) |
| Hgene | Tgene |
| PLXNA1 | TNK2 |
| Coreceptor for SEMA3A, SEMA3C, SEMA3F and SEMA6D.Necessary for signaling by class 3 semaphorins and subsequentremodeling of the cytoskeleton. Plays a role in axon guidance,invasive growth and cell migration. Class 3 semaphorins bind to acomplex composed of a neuropilin and a plexin. The plexinmodulates the affinity of the complex for specific semaphorins,and its cytoplasmic domain is required for the activation of down-stream signaling events in the cytoplasm (By similarity).{ECO:0000250}. | Non-receptor tyrosine-protein and serine/threonine-protein kinase that is implicated in cell spreading and migration,cell survival, cell growth and proliferation. Transducesextracellular signals to cytosolic and nuclear effectors.Phosphorylates AKT1, AR, MCF2, WASL and WWOX. Implicated intrafficking and clathrin-mediated endocytosis through binding toepidermal growth factor receptor (EGFR) and clathrin. Binds toboth poly- and mono-ubiquitin and regulates ligand-induceddegradation of EGFR, thereby contributing to the accumulation ofEGFR at the limiting membrane of early endosomes. Downstreameffector of CDC42 which mediates CDC42-dependent cell migrationvia phosphorylation of BCAR1. May be involved both in adultsynaptic function and plasticity and in brain development.Activates AKT1 by phosphorylating it on 'Tyr-176'. PhosphorylatesAR on 'Tyr-267' and 'Tyr-363' thereby promoting its recruitment toandrogen-responsive enhancers (AREs). Phosphorylates WWOX on 'Tyr-287'. Phosphorylates MCF2, thereby enhancing its activity as aguanine nucleotide exchange factor (GEF) toward Rho familyproteins. Contributes to the control of AXL receptor levels.Confers metastatic properties on cancer cells and promotes tumorgrowth by negatively regulating tumor suppressor such as WWOX andpositively regulating pro-survival factors such as AKT1 and AR.Phosphorylates WASP (PubMed:20110370).{ECO:0000269|PubMed:10652228, ECO:0000269|PubMed:11278436,ECO:0000269|PubMed:16247015, ECO:0000269|PubMed:16257963,ECO:0000269|PubMed:16472662, ECO:0000269|PubMed:17038317,ECO:0000269|PubMed:18262180, ECO:0000269|PubMed:18435854,ECO:0000269|PubMed:19815557, ECO:0000269|PubMed:20110370,ECO:0000269|PubMed:20333297, ECO:0000269|PubMed:20383201}. |
| Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at . * Minus value of BPloci means that the break pointn is located before the CDS. |
| - In-frame and retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
| Tgene | >TNK2 | chr3:126710409 | chr3:195615477 | ENST00000316664 | - | 0 | 11 | 577_958 | -6 | 529 | Compositional bias | Note=Pro-rich |
| Tgene | >TNK2 | chr3:126710409 | chr3:195615477 | ENST00000333602 | - | 0 | 15 | 577_958 | -6 | 1039 | Compositional bias | Note=Pro-rich |
| Tgene | >TNK2 | chr3:126710409 | chr3:195615477 | ENST00000381916 | - | 0 | 15 | 577_958 | 57 | 1087 | Compositional bias | Note=Pro-rich |
| Tgene | >TNK2 | chr3:126710409 | chr3:195615477 | ENST00000392400 | - | 0 | 15 | 577_958 | -6 | 1039 | Compositional bias | Note=Pro-rich |
| Tgene | >TNK2 | chr3:126710409 | chr3:195615477 | ENST00000316664 | - | 0 | 11 | 126_385 | -6 | 529 | Domain | Protein kinase |
| Tgene | >TNK2 | chr3:126710409 | chr3:195615477 | ENST00000316664 | - | 0 | 11 | 388_448 | -6 | 529 | Domain | SH3 |
| Tgene | >TNK2 | chr3:126710409 | chr3:195615477 | ENST00000316664 | - | 0 | 11 | 454_466 | -6 | 529 | Domain | Note=CRIB |
| Tgene | >TNK2 | chr3:126710409 | chr3:195615477 | ENST00000316664 | - | 0 | 11 | 958_996 | -6 | 529 | Domain | Note=UBA |
| Tgene | >TNK2 | chr3:126710409 | chr3:195615477 | ENST00000333602 | - | 0 | 15 | 126_385 | -6 | 1039 | Domain | Protein kinase |
| Tgene | >TNK2 | chr3:126710409 | chr3:195615477 | ENST00000333602 | - | 0 | 15 | 388_448 | -6 | 1039 | Domain | SH3 |
| Tgene | >TNK2 | chr3:126710409 | chr3:195615477 | ENST00000333602 | - | 0 | 15 | 454_466 | -6 | 1039 | Domain | Note=CRIB |
| Tgene | >TNK2 | chr3:126710409 | chr3:195615477 | ENST00000333602 | - | 0 | 15 | 958_996 | -6 | 1039 | Domain | Note=UBA |
| Tgene | >TNK2 | chr3:126710409 | chr3:195615477 | ENST00000381916 | - | 0 | 15 | 126_385 | 57 | 1087 | Domain | Protein kinase |
| Tgene | >TNK2 | chr3:126710409 | chr3:195615477 | ENST00000381916 | - | 0 | 15 | 388_448 | 57 | 1087 | Domain | SH3 |
| Tgene | >TNK2 | chr3:126710409 | chr3:195615477 | ENST00000381916 | - | 0 | 15 | 454_466 | 57 | 1087 | Domain | Note=CRIB |
| Tgene | >TNK2 | chr3:126710409 | chr3:195615477 | ENST00000381916 | - | 0 | 15 | 958_996 | 57 | 1087 | Domain | Note=UBA |
| Tgene | >TNK2 | chr3:126710409 | chr3:195615477 | ENST00000392400 | - | 0 | 15 | 126_385 | -6 | 1039 | Domain | Protein kinase |
| Tgene | >TNK2 | chr3:126710409 | chr3:195615477 | ENST00000392400 | - | 0 | 15 | 388_448 | -6 | 1039 | Domain | SH3 |
| Tgene | >TNK2 | chr3:126710409 | chr3:195615477 | ENST00000392400 | - | 0 | 15 | 454_466 | -6 | 1039 | Domain | Note=CRIB |
| Tgene | >TNK2 | chr3:126710409 | chr3:195615477 | ENST00000392400 | - | 0 | 15 | 958_996 | -6 | 1039 | Domain | Note=UBA |
| Tgene | >TNK2 | chr3:126710409 | chr3:195615477 | ENST00000316664 | - | 0 | 11 | 132_140 | -6 | 529 | Nucleotide binding | Note=ATP |
| Tgene | >TNK2 | chr3:126710409 | chr3:195615477 | ENST00000333602 | - | 0 | 15 | 132_140 | -6 | 1039 | Nucleotide binding | Note=ATP |
| Tgene | >TNK2 | chr3:126710409 | chr3:195615477 | ENST00000381916 | - | 0 | 15 | 132_140 | 57 | 1087 | Nucleotide binding | Note=ATP |
| Tgene | >TNK2 | chr3:126710409 | chr3:195615477 | ENST00000392400 | - | 0 | 15 | 132_140 | -6 | 1039 | Nucleotide binding | Note=ATP |
| Tgene | >TNK2 | chr3:126710409 | chr3:195615477 | ENST00000316664 | - | 0 | 11 | 1_110 | -6 | 529 | Region | Note=SAM-like domain |
| Tgene | >TNK2 | chr3:126710409 | chr3:195615477 | ENST00000316664 | - | 0 | 11 | 733_876 | -6 | 529 | Region | EBD domain |
| Tgene | >TNK2 | chr3:126710409 | chr3:195615477 | ENST00000333602 | - | 0 | 15 | 1_110 | -6 | 1039 | Region | Note=SAM-like domain |
| Tgene | >TNK2 | chr3:126710409 | chr3:195615477 | ENST00000333602 | - | 0 | 15 | 733_876 | -6 | 1039 | Region | EBD domain |
| Tgene | >TNK2 | chr3:126710409 | chr3:195615477 | ENST00000381916 | - | 0 | 15 | 733_876 | 57 | 1087 | Region | EBD domain |
| Tgene | >TNK2 | chr3:126710409 | chr3:195615477 | ENST00000392400 | - | 0 | 15 | 1_110 | -6 | 1039 | Region | Note=SAM-like domain |
| Tgene | >TNK2 | chr3:126710409 | chr3:195615477 | ENST00000392400 | - | 0 | 15 | 733_876 | -6 | 1039 | Region | EBD domain |
| - In-frame and not-retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
| Hgene | >PLXNA1 | chr3:126710409 | chr3:195615477 | ENST00000393409 | + | 2 | 31 | 1264_1317 | 459 | 1897 | Coiled coil | Ontology_term=ECO:0000255 |
| Hgene | >PLXNA1 | chr3:126710409 | chr3:195615477 | ENST00000393409 | + | 2 | 31 | 1048_1147 | 459 | 1897 | Domain | Note=IPT/TIG 3 |
| Hgene | >PLXNA1 | chr3:126710409 | chr3:195615477 | ENST00000393409 | + | 2 | 31 | 1150_1236 | 459 | 1897 | Domain | Note=IPT/TIG 4 |
| Hgene | >PLXNA1 | chr3:126710409 | chr3:195615477 | ENST00000393409 | + | 2 | 31 | 27_512 | 459 | 1897 | Domain | Sema |
| Hgene | >PLXNA1 | chr3:126710409 | chr3:195615477 | ENST00000393409 | + | 2 | 31 | 864_959 | 459 | 1897 | Domain | Note=IPT/TIG 1 |
| Hgene | >PLXNA1 | chr3:126710409 | chr3:195615477 | ENST00000393409 | + | 2 | 31 | 961_1045 | 459 | 1897 | Domain | Note=IPT/TIG 2 |
| Hgene | >PLXNA1 | chr3:126710409 | chr3:195615477 | ENST00000393409 | + | 2 | 31 | 1266_1896 | 459 | 1897 | Topological domain | Cytoplasmic |
| Hgene | >PLXNA1 | chr3:126710409 | chr3:195615477 | ENST00000393409 | + | 2 | 31 | 27_1244 | 459 | 1897 | Topological domain | Extracellular |
| Hgene | >PLXNA1 | chr3:126710409 | chr3:195615477 | ENST00000393409 | + | 2 | 31 | 1245_1265 | 459 | 1897 | Transmembrane | Helical |
| Tgene | TNK2 | chr3:126710409 | chr3:195615477 | ENST00000381916 | - | 0 | 15 | 1_110 | 57 | 1087 | Region | Note=SAM-like domain |
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FusionGeneSequence for PLXNA1_TNK2 |
| For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. (nt: nucleotides, aa: amino acids) |
| * Fusion amino acid sequences. |
| >In-frame_PLXNA1_ENST00000393409_chr3_126710409_+_TNK2_ENST00000381916_chr3_195615477_-_1489aa MPLPPRSLQVLLLLLLLLLLLPGMWAEAGLPRAGGGSQPPFRTFSASDWGLTHLVVHEQTGEVYVGAVNRIYKLSGNLTLLRAHVTGPVE DNEKCYPPPSVQSCPHGLGSTDNVNKLLLLDYAANRLLACGSASQGICQFLRLDDLFKLGEPHHRKEHYLSSVQEAGSMAGVLIAGPPGQ GQAKLFVGTPIDGKSEYFPTLSSRRLMANEEDADMFGFVYQDEFVSSQLKIPSDTLSKFPAFDIYYVYSFRSEQFVYYLTLQLDTQLTSP DAAGEHFFTSKIVRLCVDDPKFYSYVEFPIGCEQAGVEYRLVQDAYLSRPGRALAHQLGLAEDEDVLFTVFAQGQKNRVKPPKESALCLF TLRAIKEKIKERIQSCYRGEGKLSLPWLLNKELGCINSPLQIDDDFCGQDFNQPLGGTVTIEGTPLFVDKDDGLTAVAAYDYRGRTVVFA GTRSGRIRKRLGGGRMQPEEGTGWLLELLSEVQLQQYFLRLRDDLNVTRLSHFEYVKNEDLEKIGMGRPGQRRLWEAVKRRKALCKRKSW MSKVFSGKRLEAEFPPHHSQSTFRKTSPAPGGPAGEGPLQSLTCLIGEKDLRLLEKLGDGSFGVVRRGEWDAPSGKTVSVAVKCLKPDVL SQPEAMDDFIREVNAMHSLDHRNLIRLYGVVLTPPMKMVTELAPLGSLLDRLRKHQGHFLLGTLSRYAVQVAEGMGYLESKRFIHRDLAA RNLLLATRDLVKIGDFGLMRALPQNDDHYVMQEHRKVPFAWCAPESLKTRTFSHASDTWMFGVTLWEMFTYGQEPWIGLNGSQILHKIDK EGERLPRPEDCPQDIYNVMVQCWAHKPEDRPTFVALRDFLLEAQPTDMRALQDFEEPDKLHIQMNDVITVIEGRAENYWWRGQNTRTLCV GPFPRNVVTSVAGLSAQDISQPLQNSFIHTGHGDSDPRHCWGFPDRIDELYLGNPMDPPDLLSVELSTSRPPQHLGGVKREPPPRPPQPA FFTQKPTYDPVSEDQDPLSSDFKRLGLRKPGLPRGLWLAKPSARVPGTKASRGSGAEVTLIDFGEEPVVPALRPCAPSLAQLAMDACSLL DETPPQSPTRALPRPLHPTPVVDWDARPLPPPPAYDDVAQDEDDFEICSINSTLVGAGVPAGPSQGQTNYAFVPEQARPPPPLEDNLFLP PQGGGKPPSSAQTAEIFQALQQECMRQLQAPAGSPAPSPSPGGDDKPQVPPRVPIPPRPTRPHVQLSPAPPGEEETSQWPGPASPPRVPP REPLSPQGSRTPSPLVPPGSSPLPPRLSSSPGKTMPTTQSFASDPKYATPQVIQAPGPRAGPCILPIVRDGKKVSSTHYYLLPERPSYLE RYQRFLREAQSPEEPTPLPVPLLLPPPSTPAPAAPTATVRPMPQAALDPKANFSTNNSNPGARPPPPRATARLPQRGCPGDGPEAGRPAD >In-frame_PLXNA1_ENST00000251772_chr3_126710409_+_TNK2_ENST00000381916_chr3_195615477_-_1466aa MWAEAGLPRAGGGSQPPFRTFSASDWGLTHLVVHEQTGEVYVGAVNRIYKLSGNLTLLRAHVTGPVEDNEKCYPPPSVQSCPHGLGSTDN VNKLLLLDYAANRLLACGSASQGICQFLRLDDLFKLGEPHHRKEHYLSSVQEAGSMAGVLIAGPPGQGQAKLFVGTPIDGKSEYFPTLSS RRLMANEEDADMFGFVYQDEFVSSQLKIPSDTLSKFPAFDIYYVYSFRSEQFVYYLTLQLDTQLTSPDAAGEHFFTSKIVRLCVDDPKFY SYVEFPIGCEQAGVEYRLVQDAYLSRPGRALAHQLGLAEDEDVLFTVFAQGQKNRVKPPKESALCLFTLRAIKEKIKERIQSCYRGEGKL SLPWLLNKELGCINSPLQIDDDFCGQDFNQPLGGTVTIEGTPLFVDKDDGLTAVAAYDYRGRTVVFAGTRSGRIRKRLGGGRMQPEEGTG WLLELLSEVQLQQYFLRLRDDLNVTRLSHFEYVKNEDLEKIGMGRPGQRRLWEAVKRRKALCKRKSWMSKVFSGKRLEAEFPPHHSQSTF RKTSPAPGGPAGEGPLQSLTCLIGEKDLRLLEKLGDGSFGVVRRGEWDAPSGKTVSVAVKCLKPDVLSQPEAMDDFIREVNAMHSLDHRN LIRLYGVVLTPPMKMVTELAPLGSLLDRLRKHQGHFLLGTLSRYAVQVAEGMGYLESKRFIHRDLAARNLLLATRDLVKIGDFGLMRALP QNDDHYVMQEHRKVPFAWCAPESLKTRTFSHASDTWMFGVTLWEMFTYGQEPWIGLNGSQILHKIDKEGERLPRPEDCPQDIYNVMVQCW AHKPEDRPTFVALRDFLLEAQPTDMRALQDFEEPDKLHIQMNDVITVIEGRAENYWWRGQNTRTLCVGPFPRNVVTSVAGLSAQDISQPL QNSFIHTGHGDSDPRHCWGFPDRIDELYLGNPMDPPDLLSVELSTSRPPQHLGGVKREPPPRPPQPAFFTQKPTYDPVSEDQDPLSSDFK RLGLRKPGLPRGLWLAKPSARVPGTKASRGSGAEVTLIDFGEEPVVPALRPCAPSLAQLAMDACSLLDETPPQSPTRALPRPLHPTPVVD WDARPLPPPPAYDDVAQDEDDFEICSINSTLVGAGVPAGPSQGQTNYAFVPEQARPPPPLEDNLFLPPQGGGKPPSSAQTAEIFQALQQE CMRQLQAPAGSPAPSPSPGGDDKPQVPPRVPIPPRPTRPHVQLSPAPPGEEETSQWPGPASPPRVPPREPLSPQGSRTPSPLVPPGSSPL PPRLSSSPGKTMPTTQSFASDPKYATPQVIQAPGPRAGPCILPIVRDGKKVSSTHYYLLPERPSYLERYQRFLREAQSPEEPTPLPVPLL LPPPSTPAPAAPTATVRPMPQAALDPKANFSTNNSNPGARPPPPRATARLPQRGCPGDGPEAGRPADKIQMVEQLFGLGLRPRGECHKVL |
| * Fusion transcript sequences (only coding sequence (CDS) region). |
| >In-frame_PLXNA1_ENST00000393409_chr3_126710409_+_TNK2_ENST00000381916_chr3_195615477_-_4467nt ATGCCGCTGCCACCGCGGAGCCTGCAGGTGCTCCTGCTGCTGCTGCTGTTGCTGCTGCTGCTGCCGGGCATGTGGGCTGAGGCAGGCTTG CCCAGGGCAGGCGGGGGTTCACAGCCCCCCTTCCGCACCTTCTCGGCCAGCGACTGGGGCCTCACCCACCTAGTGGTGCATGAGCAGACA GGCGAGGTGTATGTGGGCGCAGTGAACCGCATCTATAAGCTGTCGGGGAACCTGACACTGCTGCGGGCCCACGTCACGGGCCCTGTGGAG GACAACGAGAAGTGCTACCCGCCGCCCAGCGTGCAGTCCTGCCCCCACGGCCTGGGCAGTACTGACAACGTCAACAAGCTGCTGCTGCTG GACTATGCCGCTAACCGCCTGCTGGCCTGTGGCAGCGCCTCCCAGGGCATCTGCCAGTTCCTGCGTCTGGACGATCTCTTCAAACTGGGT GAGCCACACCACCGTAAGGAGCACTACCTGTCCAGCGTGCAGGAGGCAGGCAGCATGGCGGGCGTGCTCATTGCCGGGCCACCGGGCCAG GGCCAGGCCAAGCTCTTCGTGGGCACACCCATCGATGGCAAGTCCGAGTACTTCCCCACACTGTCCAGCCGTCGGCTCATGGCCAACGAG GAGGATGCCGACATGTTCGGCTTCGTGTACCAGGATGAGTTTGTGTCATCACAGCTCAAGATCCCTTCGGACACGCTGTCCAAGTTCCCG GCCTTTGACATCTACTATGTGTACAGCTTCCGCAGCGAGCAGTTTGTCTACTACCTCACGCTGCAGCTAGACACACAGCTGACCTCGCCT GATGCCGCCGGCGAGCACTTCTTCACGTCCAAGATCGTGCGGCTCTGTGTGGACGACCCCAAATTCTACTCGTACGTTGAGTTCCCCATT GGCTGCGAGCAGGCGGGTGTGGAGTACCGCCTGGTGCAGGATGCCTACCTGAGCCGGCCCGGCCGTGCCCTGGCCCACCAGCTGGGCCTG GCTGAGGACGAGGACGTGCTGTTCACTGTGTTCGCCCAGGGCCAGAAGAACCGCGTGAAGCCACCAAAGGAGTCAGCACTGTGCCTGTTC ACGCTCAGGGCCATCAAGGAGAAGATTAAGGAGCGCATCCAGTCCTGCTACCGTGGTGAGGGCAAGCTCTCCCTGCCGTGGCTGCTCAAC AAGGAGCTGGGCTGCATCAACTCGCCCCTGCAGATCGATGACGACTTCTGCGGGCAGGACTTCAACCAGCCCCTGGGGGGCACAGTCACC ATTGAGGGGACGCCCCTGTTCGTGGACAAGGATGATGGCCTGACCGCCGTGGCTGCCTATGACTATCGGGGCCGCACTGTGGTATTCGCC GGCACGCGAAGTGGCCGCATCCGCAAGAGGCTGGGAGGCGGCAGAATGCAGCCAGAGGAGGGCACAGGCTGGCTGCTGGAGCTGCTGTCC GAGGTGCAGCTGCAACAGTACTTCCTGCGGCTCCGAGATGACCTCAACGTCACCCGCCTGTCCCACTTTGAGTACGTCAAGAATGAGGAC CTGGAGAAGATCGGCATGGGTCGGCCTGGCCAGCGGCGGCTGTGGGAGGCTGTGAAGAGGAGGAAGGCCTTGTGCAAACGCAAGTCGTGG ATGAGTAAGGTGTTCAGTGGAAAGCGACTGGAGGCTGAGTTCCCACCTCATCACTCTCAGAGCACCTTCCGGAAGACCTCGCCCGCCCCT GGGGGCCCAGCAGGGGAGGGGCCCCTGCAGAGCCTCACCTGCCTCATTGGGGAGAAGGACCTGCGCCTCCTGGAGAAGCTGGGTGATGGT TCCTTTGGCGTGGTGCGCAGGGGCGAGTGGGACGCGCCCTCAGGGAAGACGGTGAGTGTGGCTGTGAAGTGCCTGAAGCCCGATGTCCTG AGCCAGCCAGAAGCCATGGACGACTTCATCCGGGAGGTCAATGCCATGCACTCGCTCGACCACCGAAACCTCATCCGCCTCTACGGGGTG GTGCTCACGCCGCCCATGAAGATGGTGACAGAGCTGGCACCTCTGGGATCGTTGTTGGACCGGCTACGTAAGCACCAGGGCCACTTCCTC CTGGGGACTCTGAGCCGCTACGCTGTGCAGGTGGCTGAGGGCATGGGCTACCTGGAGTCCAAGCGCTTTATTCACCGTGACCTGGCTGCC CGCAATCTGCTGTTGGCTACCCGCGACCTGGTCAAGATCGGGGACTTTGGGCTGATGCGAGCACTACCTCAGAATGACGACCATTACGTC ATGCAGGAACATCGCAAGGTGCCCTTCGCCTGGTGTGCCCCCGAGAGCCTGAAGACACGCACCTTCTCCCATGCCAGCGACACCTGGATG TTCGGGGTGACACTGTGGGAAATGTTCACCTACGGCCAGGAGCCCTGGATCGGCCTCAACGGCAGTCAGATCCTGCATAAGATCGACAAG GAGGGGGAGCGGCTGCCCCGGCCCGAGGACTGTCCCCAGGACATCTACAACGTCATGGTCCAGTGCTGGGCTCACAAGCCAGAGGACAGA CCCACGTTTGTGGCCCTGCGGGACTTCCTGCTGGAGGCCCAGCCCACAGACATGCGGGCCCTTCAGGACTTTGAGGAACCGGACAAGCTG CACATCCAGATGAATGATGTCATCACCGTCATCGAGGGAAGGGCCGAGAACTACTGGTGGCGTGGCCAGAACACACGGACGCTGTGTGTG GGGCCCTTCCCTCGCAACGTGGTGACCTCCGTGGCCGGCCTGTCGGCCCAGGACATCAGCCAGCCCCTGCAGAACAGCTTCATCCACACA GGGCATGGCGACAGTGACCCCCGCCACTGCTGGGGCTTCCCGGACAGGATTGACGAACTGTATCTGGGAAACCCCATGGACCCCCCCGAC CTCCTGAGCGTGGAACTGAGCACCTCCCGGCCCCCCCAGCATCTAGGAGGGGTGAAAAGGGAGCCTCCACCTCGCCCACCTCAGCCTGCC TTCTTCACTCAGAAACCAACCTATGACCCTGTGAGCGAGGACCAAGACCCCTTGTCCAGCGACTTCAAGAGGCTGGGCCTGCGGAAGCCA GGCCTGCCCCGAGGGCTGTGGCTGGCGAAGCCCTCGGCGCGGGTGCCGGGCACCAAGGCCAGCCGAGGCAGCGGGGCTGAGGTCACGCTC ATCGACTTCGGTGAGGAGCCCGTGGTCCCGGCCCTACGGCCCTGCGCGCCCTCCCTGGCGCAGCTGGCCATGGACGCCTGCTCCCTGCTG GACGAGACCCCGCCTCAGAGCCCCACGCGGGCACTGCCCCGGCCCCTGCACCCCACGCCTGTGGTGGACTGGGACGCACGCCCGCTGCCC CCCCCGCCCGCCTATGACGACGTGGCCCAGGATGAGGATGACTTTGAGATCTGCTCCATCAACAGCACCCTCGTGGGCGCGGGGGTCCCT GCCGGGCCCAGCCAGGGCCAGACCAACTACGCCTTTGTGCCTGAGCAGGCGCGGCCGCCCCCTCCCCTGGAGGACAACCTGTTCCTCCCG CCCCAGGGTGGGGGCAAGCCGCCCAGCTCCGCACAGACCGCAGAGATCTTCCAGGCGCTACAGCAGGAGTGCATGAGGCAACTGCAGGCT CCGGCCGGCTCCCCGGCCCCCTCTCCCAGCCCGGGGGGTGACGACAAGCCCCAGGTGCCTCCTCGGGTACCCATCCCCCCTCGGCCCACG CGCCCACACGTCCAGCTGTCTCCAGCCCCCCCGGGCGAGGAGGAGACCAGCCAGTGGCCTGGACCTGCTTCCCCTCCCCGGGTGCCTCCG CGGGAGCCCCTGTCCCCTCAAGGCTCGAGGACACCCAGCCCCCTGGTACCACCTGGCAGCTCCCCGCTGCCACCCCGGCTCTCAAGCTCA CCTGGGAAGACCATGCCCACCACCCAGAGCTTTGCCTCAGACCCCAAGTACGCCACCCCCCAGGTGATCCAGGCCCCTGGCCCGCGGGCT GGTCCCTGCATCCTGCCCATCGTCCGGGATGGCAAGAAGGTCAGCAGCACCCACTATTACTTGCTGCCCGAGCGACCATCCTACCTGGAG CGCTACCAGCGCTTCCTGCGTGAGGCCCAGAGCCCCGAGGAGCCTACCCCCCTGCCTGTGCCTCTGCTGCTGCCCCCACCCAGCACCCCA GCCCCCGCCGCCCCCACGGCCACCGTGCGGCCGATGCCCCAGGCTGCCTTGGACCCCAAGGCCAACTTCTCCACCAACAACAGCAACCCA GGGGCCCGGCCACCACCCCCGAGGGCCACTGCTCGGCTGCCACAGAGGGGCTGCCCTGGCGATGGGCCAGAGGCGGGCCGGCCAGCAGAC AAGATCCAGATGGTGGAGCAGCTCTTCGGGCTGGGTCTGCGGCCCAGAGGGGAGTGCCACAAAGTGCTGGAGATGTTCGACTGGAACCTG >In-frame_PLXNA1_ENST00000251772_chr3_126710409_+_TNK2_ENST00000381916_chr3_195615477_-_4398nt ATGTGGGCTGAGGCAGGCTTGCCCAGGGCAGGCGGGGGTTCACAGCCCCCCTTCCGCACCTTCTCGGCCAGCGACTGGGGCCTCACCCAC CTAGTGGTGCATGAGCAGACAGGCGAGGTGTATGTGGGCGCAGTGAACCGCATCTATAAGCTGTCGGGGAACCTGACACTGCTGCGGGCC CACGTCACGGGCCCTGTGGAGGACAACGAGAAGTGCTACCCGCCGCCCAGCGTGCAGTCCTGCCCCCACGGCCTGGGCAGTACTGACAAC GTCAACAAGCTGCTGCTGCTGGACTATGCCGCTAACCGCCTGCTGGCCTGTGGCAGCGCCTCCCAGGGCATCTGCCAGTTCCTGCGTCTG GACGATCTCTTCAAACTGGGTGAGCCACACCACCGTAAGGAGCACTACCTGTCCAGCGTGCAGGAGGCAGGCAGCATGGCGGGCGTGCTC ATTGCCGGGCCACCGGGCCAGGGCCAGGCCAAGCTCTTCGTGGGCACACCCATCGATGGCAAGTCCGAGTACTTCCCCACACTGTCCAGC CGTCGGCTCATGGCCAACGAGGAGGATGCCGACATGTTCGGCTTCGTGTACCAGGATGAGTTTGTGTCATCACAGCTCAAGATCCCTTCG GACACGCTGTCCAAGTTCCCGGCCTTTGACATCTACTATGTGTACAGCTTCCGCAGCGAGCAGTTTGTCTACTACCTCACGCTGCAGCTA GACACACAGCTGACCTCGCCTGATGCCGCCGGCGAGCACTTCTTCACGTCCAAGATCGTGCGGCTCTGTGTGGACGACCCCAAATTCTAC TCGTACGTTGAGTTCCCCATTGGCTGCGAGCAGGCGGGTGTGGAGTACCGCCTGGTGCAGGATGCCTACCTGAGCCGGCCCGGCCGTGCC CTGGCCCACCAGCTGGGCCTGGCTGAGGACGAGGACGTGCTGTTCACTGTGTTCGCCCAGGGCCAGAAGAACCGCGTGAAGCCACCAAAG GAGTCAGCACTGTGCCTGTTCACGCTCAGGGCCATCAAGGAGAAGATTAAGGAGCGCATCCAGTCCTGCTACCGTGGTGAGGGCAAGCTC TCCCTGCCGTGGCTGCTCAACAAGGAGCTGGGCTGCATCAACTCGCCCCTGCAGATCGATGACGACTTCTGCGGGCAGGACTTCAACCAG CCCCTGGGGGGCACAGTCACCATTGAGGGGACGCCCCTGTTCGTGGACAAGGATGATGGCCTGACCGCCGTGGCTGCCTATGACTATCGG GGCCGCACTGTGGTATTCGCCGGCACGCGAAGTGGCCGCATCCGCAAGAGGCTGGGAGGCGGCAGAATGCAGCCAGAGGAGGGCACAGGC TGGCTGCTGGAGCTGCTGTCCGAGGTGCAGCTGCAACAGTACTTCCTGCGGCTCCGAGATGACCTCAACGTCACCCGCCTGTCCCACTTT GAGTACGTCAAGAATGAGGACCTGGAGAAGATCGGCATGGGTCGGCCTGGCCAGCGGCGGCTGTGGGAGGCTGTGAAGAGGAGGAAGGCC TTGTGCAAACGCAAGTCGTGGATGAGTAAGGTGTTCAGTGGAAAGCGACTGGAGGCTGAGTTCCCACCTCATCACTCTCAGAGCACCTTC CGGAAGACCTCGCCCGCCCCTGGGGGCCCAGCAGGGGAGGGGCCCCTGCAGAGCCTCACCTGCCTCATTGGGGAGAAGGACCTGCGCCTC CTGGAGAAGCTGGGTGATGGTTCCTTTGGCGTGGTGCGCAGGGGCGAGTGGGACGCGCCCTCAGGGAAGACGGTGAGTGTGGCTGTGAAG TGCCTGAAGCCCGATGTCCTGAGCCAGCCAGAAGCCATGGACGACTTCATCCGGGAGGTCAATGCCATGCACTCGCTCGACCACCGAAAC CTCATCCGCCTCTACGGGGTGGTGCTCACGCCGCCCATGAAGATGGTGACAGAGCTGGCACCTCTGGGATCGTTGTTGGACCGGCTACGT AAGCACCAGGGCCACTTCCTCCTGGGGACTCTGAGCCGCTACGCTGTGCAGGTGGCTGAGGGCATGGGCTACCTGGAGTCCAAGCGCTTT ATTCACCGTGACCTGGCTGCCCGCAATCTGCTGTTGGCTACCCGCGACCTGGTCAAGATCGGGGACTTTGGGCTGATGCGAGCACTACCT CAGAATGACGACCATTACGTCATGCAGGAACATCGCAAGGTGCCCTTCGCCTGGTGTGCCCCCGAGAGCCTGAAGACACGCACCTTCTCC CATGCCAGCGACACCTGGATGTTCGGGGTGACACTGTGGGAAATGTTCACCTACGGCCAGGAGCCCTGGATCGGCCTCAACGGCAGTCAG ATCCTGCATAAGATCGACAAGGAGGGGGAGCGGCTGCCCCGGCCCGAGGACTGTCCCCAGGACATCTACAACGTCATGGTCCAGTGCTGG GCTCACAAGCCAGAGGACAGACCCACGTTTGTGGCCCTGCGGGACTTCCTGCTGGAGGCCCAGCCCACAGACATGCGGGCCCTTCAGGAC TTTGAGGAACCGGACAAGCTGCACATCCAGATGAATGATGTCATCACCGTCATCGAGGGAAGGGCCGAGAACTACTGGTGGCGTGGCCAG AACACACGGACGCTGTGTGTGGGGCCCTTCCCTCGCAACGTGGTGACCTCCGTGGCCGGCCTGTCGGCCCAGGACATCAGCCAGCCCCTG CAGAACAGCTTCATCCACACAGGGCATGGCGACAGTGACCCCCGCCACTGCTGGGGCTTCCCGGACAGGATTGACGAACTGTATCTGGGA AACCCCATGGACCCCCCCGACCTCCTGAGCGTGGAACTGAGCACCTCCCGGCCCCCCCAGCATCTAGGAGGGGTGAAAAGGGAGCCTCCA CCTCGCCCACCTCAGCCTGCCTTCTTCACTCAGAAACCAACCTATGACCCTGTGAGCGAGGACCAAGACCCCTTGTCCAGCGACTTCAAG AGGCTGGGCCTGCGGAAGCCAGGCCTGCCCCGAGGGCTGTGGCTGGCGAAGCCCTCGGCGCGGGTGCCGGGCACCAAGGCCAGCCGAGGC AGCGGGGCTGAGGTCACGCTCATCGACTTCGGTGAGGAGCCCGTGGTCCCGGCCCTACGGCCCTGCGCGCCCTCCCTGGCGCAGCTGGCC ATGGACGCCTGCTCCCTGCTGGACGAGACCCCGCCTCAGAGCCCCACGCGGGCACTGCCCCGGCCCCTGCACCCCACGCCTGTGGTGGAC TGGGACGCACGCCCGCTGCCCCCCCCGCCCGCCTATGACGACGTGGCCCAGGATGAGGATGACTTTGAGATCTGCTCCATCAACAGCACC CTCGTGGGCGCGGGGGTCCCTGCCGGGCCCAGCCAGGGCCAGACCAACTACGCCTTTGTGCCTGAGCAGGCGCGGCCGCCCCCTCCCCTG GAGGACAACCTGTTCCTCCCGCCCCAGGGTGGGGGCAAGCCGCCCAGCTCCGCACAGACCGCAGAGATCTTCCAGGCGCTACAGCAGGAG TGCATGAGGCAACTGCAGGCTCCGGCCGGCTCCCCGGCCCCCTCTCCCAGCCCGGGGGGTGACGACAAGCCCCAGGTGCCTCCTCGGGTA CCCATCCCCCCTCGGCCCACGCGCCCACACGTCCAGCTGTCTCCAGCCCCCCCGGGCGAGGAGGAGACCAGCCAGTGGCCTGGACCTGCT TCCCCTCCCCGGGTGCCTCCGCGGGAGCCCCTGTCCCCTCAAGGCTCGAGGACACCCAGCCCCCTGGTACCACCTGGCAGCTCCCCGCTG CCACCCCGGCTCTCAAGCTCACCTGGGAAGACCATGCCCACCACCCAGAGCTTTGCCTCAGACCCCAAGTACGCCACCCCCCAGGTGATC CAGGCCCCTGGCCCGCGGGCTGGTCCCTGCATCCTGCCCATCGTCCGGGATGGCAAGAAGGTCAGCAGCACCCACTATTACTTGCTGCCC GAGCGACCATCCTACCTGGAGCGCTACCAGCGCTTCCTGCGTGAGGCCCAGAGCCCCGAGGAGCCTACCCCCCTGCCTGTGCCTCTGCTG CTGCCCCCACCCAGCACCCCAGCCCCCGCCGCCCCCACGGCCACCGTGCGGCCGATGCCCCAGGCTGCCTTGGACCCCAAGGCCAACTTC TCCACCAACAACAGCAACCCAGGGGCCCGGCCACCACCCCCGAGGGCCACTGCTCGGCTGCCACAGAGGGGCTGCCCTGGCGATGGGCCA GAGGCGGGCCGGCCAGCAGACAAGATCCAGATGGTGGAGCAGCTCTTCGGGCTGGGTCTGCGGCCCAGAGGGGAGTGCCACAAAGTGCTG |
| * Fusion transcript sequences (Full-length transcript). |
| >In-frame_PLXNA1_ENST00000393409_chr3_126710409_+_TNK2_ENST00000381916_chr3_195615477_-_5284nt ATGCCGCTGCCACCGCGGAGCCTGCAGGTGCTCCTGCTGCTGCTGCTGTTGCTGCTGCTGCTGCCGGGCATGTGGGCTGAGGCAGGCTTG CCCAGGGCAGGCGGGGGTTCACAGCCCCCCTTCCGCACCTTCTCGGCCAGCGACTGGGGCCTCACCCACCTAGTGGTGCATGAGCAGACA GGCGAGGTGTATGTGGGCGCAGTGAACCGCATCTATAAGCTGTCGGGGAACCTGACACTGCTGCGGGCCCACGTCACGGGCCCTGTGGAG GACAACGAGAAGTGCTACCCGCCGCCCAGCGTGCAGTCCTGCCCCCACGGCCTGGGCAGTACTGACAACGTCAACAAGCTGCTGCTGCTG GACTATGCCGCTAACCGCCTGCTGGCCTGTGGCAGCGCCTCCCAGGGCATCTGCCAGTTCCTGCGTCTGGACGATCTCTTCAAACTGGGT GAGCCACACCACCGTAAGGAGCACTACCTGTCCAGCGTGCAGGAGGCAGGCAGCATGGCGGGCGTGCTCATTGCCGGGCCACCGGGCCAG GGCCAGGCCAAGCTCTTCGTGGGCACACCCATCGATGGCAAGTCCGAGTACTTCCCCACACTGTCCAGCCGTCGGCTCATGGCCAACGAG GAGGATGCCGACATGTTCGGCTTCGTGTACCAGGATGAGTTTGTGTCATCACAGCTCAAGATCCCTTCGGACACGCTGTCCAAGTTCCCG GCCTTTGACATCTACTATGTGTACAGCTTCCGCAGCGAGCAGTTTGTCTACTACCTCACGCTGCAGCTAGACACACAGCTGACCTCGCCT GATGCCGCCGGCGAGCACTTCTTCACGTCCAAGATCGTGCGGCTCTGTGTGGACGACCCCAAATTCTACTCGTACGTTGAGTTCCCCATT GGCTGCGAGCAGGCGGGTGTGGAGTACCGCCTGGTGCAGGATGCCTACCTGAGCCGGCCCGGCCGTGCCCTGGCCCACCAGCTGGGCCTG GCTGAGGACGAGGACGTGCTGTTCACTGTGTTCGCCCAGGGCCAGAAGAACCGCGTGAAGCCACCAAAGGAGTCAGCACTGTGCCTGTTC ACGCTCAGGGCCATCAAGGAGAAGATTAAGGAGCGCATCCAGTCCTGCTACCGTGGTGAGGGCAAGCTCTCCCTGCCGTGGCTGCTCAAC AAGGAGCTGGGCTGCATCAACTCGCCCCTGCAGATCGATGACGACTTCTGCGGGCAGGACTTCAACCAGCCCCTGGGGGGCACAGTCACC ATTGAGGGGACGCCCCTGTTCGTGGACAAGGATGATGGCCTGACCGCCGTGGCTGCCTATGACTATCGGGGCCGCACTGTGGTATTCGCC GGCACGCGAAGTGGCCGCATCCGCAAGAGGCTGGGAGGCGGCAGAATGCAGCCAGAGGAGGGCACAGGCTGGCTGCTGGAGCTGCTGTCC GAGGTGCAGCTGCAACAGTACTTCCTGCGGCTCCGAGATGACCTCAACGTCACCCGCCTGTCCCACTTTGAGTACGTCAAGAATGAGGAC CTGGAGAAGATCGGCATGGGTCGGCCTGGCCAGCGGCGGCTGTGGGAGGCTGTGAAGAGGAGGAAGGCCTTGTGCAAACGCAAGTCGTGG ATGAGTAAGGTGTTCAGTGGAAAGCGACTGGAGGCTGAGTTCCCACCTCATCACTCTCAGAGCACCTTCCGGAAGACCTCGCCCGCCCCT GGGGGCCCAGCAGGGGAGGGGCCCCTGCAGAGCCTCACCTGCCTCATTGGGGAGAAGGACCTGCGCCTCCTGGAGAAGCTGGGTGATGGT TCCTTTGGCGTGGTGCGCAGGGGCGAGTGGGACGCGCCCTCAGGGAAGACGGTGAGTGTGGCTGTGAAGTGCCTGAAGCCCGATGTCCTG AGCCAGCCAGAAGCCATGGACGACTTCATCCGGGAGGTCAATGCCATGCACTCGCTCGACCACCGAAACCTCATCCGCCTCTACGGGGTG GTGCTCACGCCGCCCATGAAGATGGTGACAGAGCTGGCACCTCTGGGATCGTTGTTGGACCGGCTACGTAAGCACCAGGGCCACTTCCTC CTGGGGACTCTGAGCCGCTACGCTGTGCAGGTGGCTGAGGGCATGGGCTACCTGGAGTCCAAGCGCTTTATTCACCGTGACCTGGCTGCC CGCAATCTGCTGTTGGCTACCCGCGACCTGGTCAAGATCGGGGACTTTGGGCTGATGCGAGCACTACCTCAGAATGACGACCATTACGTC ATGCAGGAACATCGCAAGGTGCCCTTCGCCTGGTGTGCCCCCGAGAGCCTGAAGACACGCACCTTCTCCCATGCCAGCGACACCTGGATG TTCGGGGTGACACTGTGGGAAATGTTCACCTACGGCCAGGAGCCCTGGATCGGCCTCAACGGCAGTCAGATCCTGCATAAGATCGACAAG GAGGGGGAGCGGCTGCCCCGGCCCGAGGACTGTCCCCAGGACATCTACAACGTCATGGTCCAGTGCTGGGCTCACAAGCCAGAGGACAGA CCCACGTTTGTGGCCCTGCGGGACTTCCTGCTGGAGGCCCAGCCCACAGACATGCGGGCCCTTCAGGACTTTGAGGAACCGGACAAGCTG CACATCCAGATGAATGATGTCATCACCGTCATCGAGGGAAGGGCCGAGAACTACTGGTGGCGTGGCCAGAACACACGGACGCTGTGTGTG GGGCCCTTCCCTCGCAACGTGGTGACCTCCGTGGCCGGCCTGTCGGCCCAGGACATCAGCCAGCCCCTGCAGAACAGCTTCATCCACACA GGGCATGGCGACAGTGACCCCCGCCACTGCTGGGGCTTCCCGGACAGGATTGACGAACTGTATCTGGGAAACCCCATGGACCCCCCCGAC CTCCTGAGCGTGGAACTGAGCACCTCCCGGCCCCCCCAGCATCTAGGAGGGGTGAAAAGGGAGCCTCCACCTCGCCCACCTCAGCCTGCC TTCTTCACTCAGAAACCAACCTATGACCCTGTGAGCGAGGACCAAGACCCCTTGTCCAGCGACTTCAAGAGGCTGGGCCTGCGGAAGCCA GGCCTGCCCCGAGGGCTGTGGCTGGCGAAGCCCTCGGCGCGGGTGCCGGGCACCAAGGCCAGCCGAGGCAGCGGGGCTGAGGTCACGCTC ATCGACTTCGGTGAGGAGCCCGTGGTCCCGGCCCTACGGCCCTGCGCGCCCTCCCTGGCGCAGCTGGCCATGGACGCCTGCTCCCTGCTG GACGAGACCCCGCCTCAGAGCCCCACGCGGGCACTGCCCCGGCCCCTGCACCCCACGCCTGTGGTGGACTGGGACGCACGCCCGCTGCCC CCCCCGCCCGCCTATGACGACGTGGCCCAGGATGAGGATGACTTTGAGATCTGCTCCATCAACAGCACCCTCGTGGGCGCGGGGGTCCCT GCCGGGCCCAGCCAGGGCCAGACCAACTACGCCTTTGTGCCTGAGCAGGCGCGGCCGCCCCCTCCCCTGGAGGACAACCTGTTCCTCCCG CCCCAGGGTGGGGGCAAGCCGCCCAGCTCCGCACAGACCGCAGAGATCTTCCAGGCGCTACAGCAGGAGTGCATGAGGCAACTGCAGGCT CCGGCCGGCTCCCCGGCCCCCTCTCCCAGCCCGGGGGGTGACGACAAGCCCCAGGTGCCTCCTCGGGTACCCATCCCCCCTCGGCCCACG CGCCCACACGTCCAGCTGTCTCCAGCCCCCCCGGGCGAGGAGGAGACCAGCCAGTGGCCTGGACCTGCTTCCCCTCCCCGGGTGCCTCCG CGGGAGCCCCTGTCCCCTCAAGGCTCGAGGACACCCAGCCCCCTGGTACCACCTGGCAGCTCCCCGCTGCCACCCCGGCTCTCAAGCTCA CCTGGGAAGACCATGCCCACCACCCAGAGCTTTGCCTCAGACCCCAAGTACGCCACCCCCCAGGTGATCCAGGCCCCTGGCCCGCGGGCT GGTCCCTGCATCCTGCCCATCGTCCGGGATGGCAAGAAGGTCAGCAGCACCCACTATTACTTGCTGCCCGAGCGACCATCCTACCTGGAG CGCTACCAGCGCTTCCTGCGTGAGGCCCAGAGCCCCGAGGAGCCTACCCCCCTGCCTGTGCCTCTGCTGCTGCCCCCACCCAGCACCCCA GCCCCCGCCGCCCCCACGGCCACCGTGCGGCCGATGCCCCAGGCTGCCTTGGACCCCAAGGCCAACTTCTCCACCAACAACAGCAACCCA GGGGCCCGGCCACCACCCCCGAGGGCCACTGCTCGGCTGCCACAGAGGGGCTGCCCTGGCGATGGGCCAGAGGCGGGCCGGCCAGCAGAC AAGATCCAGATGGTGGAGCAGCTCTTCGGGCTGGGTCTGCGGCCCAGAGGGGAGTGCCACAAAGTGCTGGAGATGTTCGACTGGAACCTG GAGCAGGCCGGCTGCCACCTTCTGGGCTCCTGGGGCCCTGCCCACCACAAGCGCTGAGATGCGTCTGGAGAGCCAGAGGGCCTGCCTGAA GGAATCACCTGAGCCTGTCCGTCCACCAGGAGTGGGGAGATGCCCCCATCCAGTCCTGGAGGACCCGCTGCTCCTGCTGCTCCCGGGGAT GGAGCAAGGCCAAGGCTGCGGGAGGCTGGGAGCCCTGCCCTGCCCATCCCTCCTGCACCAGCGCTGTCCCTGCACACTTTGGTTCAGTCC CGGTGCCCCTGCCAAGATGTGGAAGGGGCCGGGTGAAGACAGGCTTGAGGGCTGCCCCAGCAGGCTCTGGGTATGACCTGCCTCTGGCCC TGGTCCTGGGCGGGGCCTGTGGGTGGAGTAGTACCCCCAGGCCCTGCCCTGGGTGACAGACTGGGAGGAAACCAGGCTGGACCTGGGCAG GCGGGATGTGTTGGCCACAGGGAGAGGCGGACCGGCACCCGGTGGGACCTCCTAGGACTGGGCCTTCTTCCAGGGGGCCCCTGGCAGCAG CTGGGGTGTCGGGCAGAATGTGACTTGTGGCCTTACCATGGACTTGAATGGGACTTGGCTGGCCTCAGGATCTTGTGCCTGGAAATAGCC TGAGGTGGCTCAGGAAGCGGAGAAAGGGTGCCAGACCATTCTCTGGCGGGGACCAGGGCCCAAGGCCCCAGGGCTGGAAGGAGACCAAGG GGCAGCCGCCCTGGAGGGACATCAGTGCTTCCTCTTCCACCCAATTCCCCCACGCGGTTCCATGTTTTCCCACCAGCCTGTTGGCGAAGT >In-frame_PLXNA1_ENST00000251772_chr3_126710409_+_TNK2_ENST00000381916_chr3_195615477_-_5284nt ATGCCGCTGCCACCGCGGAGCCTGCAGGTGCTCCTGCTGCTGCTGCTGTTGCTGCTGCTGCTGCCGGGCATGTGGGCTGAGGCAGGCTTG CCCAGGGCAGGCGGGGGTTCACAGCCCCCCTTCCGCACCTTCTCGGCCAGCGACTGGGGCCTCACCCACCTAGTGGTGCATGAGCAGACA GGCGAGGTGTATGTGGGCGCAGTGAACCGCATCTATAAGCTGTCGGGGAACCTGACACTGCTGCGGGCCCACGTCACGGGCCCTGTGGAG GACAACGAGAAGTGCTACCCGCCGCCCAGCGTGCAGTCCTGCCCCCACGGCCTGGGCAGTACTGACAACGTCAACAAGCTGCTGCTGCTG GACTATGCCGCTAACCGCCTGCTGGCCTGTGGCAGCGCCTCCCAGGGCATCTGCCAGTTCCTGCGTCTGGACGATCTCTTCAAACTGGGT GAGCCACACCACCGTAAGGAGCACTACCTGTCCAGCGTGCAGGAGGCAGGCAGCATGGCGGGCGTGCTCATTGCCGGGCCACCGGGCCAG GGCCAGGCCAAGCTCTTCGTGGGCACACCCATCGATGGCAAGTCCGAGTACTTCCCCACACTGTCCAGCCGTCGGCTCATGGCCAACGAG GAGGATGCCGACATGTTCGGCTTCGTGTACCAGGATGAGTTTGTGTCATCACAGCTCAAGATCCCTTCGGACACGCTGTCCAAGTTCCCG GCCTTTGACATCTACTATGTGTACAGCTTCCGCAGCGAGCAGTTTGTCTACTACCTCACGCTGCAGCTAGACACACAGCTGACCTCGCCT GATGCCGCCGGCGAGCACTTCTTCACGTCCAAGATCGTGCGGCTCTGTGTGGACGACCCCAAATTCTACTCGTACGTTGAGTTCCCCATT GGCTGCGAGCAGGCGGGTGTGGAGTACCGCCTGGTGCAGGATGCCTACCTGAGCCGGCCCGGCCGTGCCCTGGCCCACCAGCTGGGCCTG GCTGAGGACGAGGACGTGCTGTTCACTGTGTTCGCCCAGGGCCAGAAGAACCGCGTGAAGCCACCAAAGGAGTCAGCACTGTGCCTGTTC ACGCTCAGGGCCATCAAGGAGAAGATTAAGGAGCGCATCCAGTCCTGCTACCGTGGTGAGGGCAAGCTCTCCCTGCCGTGGCTGCTCAAC AAGGAGCTGGGCTGCATCAACTCGCCCCTGCAGATCGATGACGACTTCTGCGGGCAGGACTTCAACCAGCCCCTGGGGGGCACAGTCACC ATTGAGGGGACGCCCCTGTTCGTGGACAAGGATGATGGCCTGACCGCCGTGGCTGCCTATGACTATCGGGGCCGCACTGTGGTATTCGCC GGCACGCGAAGTGGCCGCATCCGCAAGAGGCTGGGAGGCGGCAGAATGCAGCCAGAGGAGGGCACAGGCTGGCTGCTGGAGCTGCTGTCC GAGGTGCAGCTGCAACAGTACTTCCTGCGGCTCCGAGATGACCTCAACGTCACCCGCCTGTCCCACTTTGAGTACGTCAAGAATGAGGAC CTGGAGAAGATCGGCATGGGTCGGCCTGGCCAGCGGCGGCTGTGGGAGGCTGTGAAGAGGAGGAAGGCCTTGTGCAAACGCAAGTCGTGG ATGAGTAAGGTGTTCAGTGGAAAGCGACTGGAGGCTGAGTTCCCACCTCATCACTCTCAGAGCACCTTCCGGAAGACCTCGCCCGCCCCT GGGGGCCCAGCAGGGGAGGGGCCCCTGCAGAGCCTCACCTGCCTCATTGGGGAGAAGGACCTGCGCCTCCTGGAGAAGCTGGGTGATGGT TCCTTTGGCGTGGTGCGCAGGGGCGAGTGGGACGCGCCCTCAGGGAAGACGGTGAGTGTGGCTGTGAAGTGCCTGAAGCCCGATGTCCTG AGCCAGCCAGAAGCCATGGACGACTTCATCCGGGAGGTCAATGCCATGCACTCGCTCGACCACCGAAACCTCATCCGCCTCTACGGGGTG GTGCTCACGCCGCCCATGAAGATGGTGACAGAGCTGGCACCTCTGGGATCGTTGTTGGACCGGCTACGTAAGCACCAGGGCCACTTCCTC CTGGGGACTCTGAGCCGCTACGCTGTGCAGGTGGCTGAGGGCATGGGCTACCTGGAGTCCAAGCGCTTTATTCACCGTGACCTGGCTGCC CGCAATCTGCTGTTGGCTACCCGCGACCTGGTCAAGATCGGGGACTTTGGGCTGATGCGAGCACTACCTCAGAATGACGACCATTACGTC ATGCAGGAACATCGCAAGGTGCCCTTCGCCTGGTGTGCCCCCGAGAGCCTGAAGACACGCACCTTCTCCCATGCCAGCGACACCTGGATG TTCGGGGTGACACTGTGGGAAATGTTCACCTACGGCCAGGAGCCCTGGATCGGCCTCAACGGCAGTCAGATCCTGCATAAGATCGACAAG GAGGGGGAGCGGCTGCCCCGGCCCGAGGACTGTCCCCAGGACATCTACAACGTCATGGTCCAGTGCTGGGCTCACAAGCCAGAGGACAGA CCCACGTTTGTGGCCCTGCGGGACTTCCTGCTGGAGGCCCAGCCCACAGACATGCGGGCCCTTCAGGACTTTGAGGAACCGGACAAGCTG CACATCCAGATGAATGATGTCATCACCGTCATCGAGGGAAGGGCCGAGAACTACTGGTGGCGTGGCCAGAACACACGGACGCTGTGTGTG GGGCCCTTCCCTCGCAACGTGGTGACCTCCGTGGCCGGCCTGTCGGCCCAGGACATCAGCCAGCCCCTGCAGAACAGCTTCATCCACACA GGGCATGGCGACAGTGACCCCCGCCACTGCTGGGGCTTCCCGGACAGGATTGACGAACTGTATCTGGGAAACCCCATGGACCCCCCCGAC CTCCTGAGCGTGGAACTGAGCACCTCCCGGCCCCCCCAGCATCTAGGAGGGGTGAAAAGGGAGCCTCCACCTCGCCCACCTCAGCCTGCC TTCTTCACTCAGAAACCAACCTATGACCCTGTGAGCGAGGACCAAGACCCCTTGTCCAGCGACTTCAAGAGGCTGGGCCTGCGGAAGCCA GGCCTGCCCCGAGGGCTGTGGCTGGCGAAGCCCTCGGCGCGGGTGCCGGGCACCAAGGCCAGCCGAGGCAGCGGGGCTGAGGTCACGCTC ATCGACTTCGGTGAGGAGCCCGTGGTCCCGGCCCTACGGCCCTGCGCGCCCTCCCTGGCGCAGCTGGCCATGGACGCCTGCTCCCTGCTG GACGAGACCCCGCCTCAGAGCCCCACGCGGGCACTGCCCCGGCCCCTGCACCCCACGCCTGTGGTGGACTGGGACGCACGCCCGCTGCCC CCCCCGCCCGCCTATGACGACGTGGCCCAGGATGAGGATGACTTTGAGATCTGCTCCATCAACAGCACCCTCGTGGGCGCGGGGGTCCCT GCCGGGCCCAGCCAGGGCCAGACCAACTACGCCTTTGTGCCTGAGCAGGCGCGGCCGCCCCCTCCCCTGGAGGACAACCTGTTCCTCCCG CCCCAGGGTGGGGGCAAGCCGCCCAGCTCCGCACAGACCGCAGAGATCTTCCAGGCGCTACAGCAGGAGTGCATGAGGCAACTGCAGGCT CCGGCCGGCTCCCCGGCCCCCTCTCCCAGCCCGGGGGGTGACGACAAGCCCCAGGTGCCTCCTCGGGTACCCATCCCCCCTCGGCCCACG CGCCCACACGTCCAGCTGTCTCCAGCCCCCCCGGGCGAGGAGGAGACCAGCCAGTGGCCTGGACCTGCTTCCCCTCCCCGGGTGCCTCCG CGGGAGCCCCTGTCCCCTCAAGGCTCGAGGACACCCAGCCCCCTGGTACCACCTGGCAGCTCCCCGCTGCCACCCCGGCTCTCAAGCTCA CCTGGGAAGACCATGCCCACCACCCAGAGCTTTGCCTCAGACCCCAAGTACGCCACCCCCCAGGTGATCCAGGCCCCTGGCCCGCGGGCT GGTCCCTGCATCCTGCCCATCGTCCGGGATGGCAAGAAGGTCAGCAGCACCCACTATTACTTGCTGCCCGAGCGACCATCCTACCTGGAG CGCTACCAGCGCTTCCTGCGTGAGGCCCAGAGCCCCGAGGAGCCTACCCCCCTGCCTGTGCCTCTGCTGCTGCCCCCACCCAGCACCCCA GCCCCCGCCGCCCCCACGGCCACCGTGCGGCCGATGCCCCAGGCTGCCTTGGACCCCAAGGCCAACTTCTCCACCAACAACAGCAACCCA GGGGCCCGGCCACCACCCCCGAGGGCCACTGCTCGGCTGCCACAGAGGGGCTGCCCTGGCGATGGGCCAGAGGCGGGCCGGCCAGCAGAC AAGATCCAGATGGTGGAGCAGCTCTTCGGGCTGGGTCTGCGGCCCAGAGGGGAGTGCCACAAAGTGCTGGAGATGTTCGACTGGAACCTG GAGCAGGCCGGCTGCCACCTTCTGGGCTCCTGGGGCCCTGCCCACCACAAGCGCTGAGATGCGTCTGGAGAGCCAGAGGGCCTGCCTGAA GGAATCACCTGAGCCTGTCCGTCCACCAGGAGTGGGGAGATGCCCCCATCCAGTCCTGGAGGACCCGCTGCTCCTGCTGCTCCCGGGGAT GGAGCAAGGCCAAGGCTGCGGGAGGCTGGGAGCCCTGCCCTGCCCATCCCTCCTGCACCAGCGCTGTCCCTGCACACTTTGGTTCAGTCC CGGTGCCCCTGCCAAGATGTGGAAGGGGCCGGGTGAAGACAGGCTTGAGGGCTGCCCCAGCAGGCTCTGGGTATGACCTGCCTCTGGCCC TGGTCCTGGGCGGGGCCTGTGGGTGGAGTAGTACCCCCAGGCCCTGCCCTGGGTGACAGACTGGGAGGAAACCAGGCTGGACCTGGGCAG GCGGGATGTGTTGGCCACAGGGAGAGGCGGACCGGCACCCGGTGGGACCTCCTAGGACTGGGCCTTCTTCCAGGGGGCCCCTGGCAGCAG CTGGGGTGTCGGGCAGAATGTGACTTGTGGCCTTACCATGGACTTGAATGGGACTTGGCTGGCCTCAGGATCTTGTGCCTGGAAATAGCC TGAGGTGGCTCAGGAAGCGGAGAAAGGGTGCCAGACCATTCTCTGGCGGGGACCAGGGCCCAAGGCCCCAGGGCTGGAAGGAGACCAAGG GGCAGCCGCCCTGGAGGGACATCAGTGCTTCCTCTTCCACCCAATTCCCCCACGCGGTTCCATGTTTTCCCACCAGCCTGTTGGCGAAGT |
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FusionGenePPI for PLXNA1_TNK2 |
| Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in . |
| Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160) |
| Hgene | Hgene's interactors | Tgene | Tgene's interactors |
| PLXNA1 | AKT1, PLXNA1, KDR, RHOD, FBXO6, PDIA3, HLA-DRA, TAZ, SUSD4, LGALS9, TMEM25, CANT1, PTCH1, PTPRK, NRP1, GAN, OS9, FAM19A4, ST8SIA4, DEFA5, SCGB1D1, DEFA1, MGAT4C | TNK2 | HSH2D, GRB2, CDC42, CLTC, FYN, MCF2, EGFR, NEDD4, CLTA, AMPH, BIN1, FABP4, NEDD4L, SMURF1, WWP2, HECW1, BAG3, MAGI3, WWOX, SRC, KAT8, KAT5, AXL, PDGFRB, LTK, ALK, EEA1, BCAR1, HSP90AA1, MERTK, AR, NPHP1, WAS, SNX9, ZBTB16, EP300, TP73, YES1, HCK, LYN, NCK1, CTTN, TNK2, KCNA5, SIAH1, SIAH2, ATG16L1, SQSTM1, NBR1, TP53, NTRK1, NTRK2, NTRK3, TRIM50, AQP1, GALT, SH2D1A, NEK6, KRTAP10-3, NOTCH2NL, NCK2, KDM3A, AKT1, PDK1, SOCS4, GAK, GTSE1, FGFR1, HSP90AB3P, ISG15, CDC37, LCP2, STAT1, HSP90AB1, HSPA9, SLC25A5, CSK, HSP90AB2P, HAX1, CRKL |
| - Retained PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
| - Lost PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
| - Retained PPIs, but lost function due to frame-shift fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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RelatedDrugs for PLXNA1_TNK2 |
| Drugs targeting genes involved in this fusion gene. (DrugBank Version 5.1.0 2018-04-02) |
| Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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RelatedDiseases for PLXNA1_TNK2 |
| Diseases associated with fusion partners. (DisGeNet 4.0) |
| Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
| Tgene | TNK2 | C0023903 | Liver neoplasms | 1 | CTD_human |
| Tgene | TNK2 | C0032927 | Precancerous Conditions | 1 | CTD_human |
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