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Fusion gene ID: 27732 |
FusionGeneSummary for PLXNA1_DZIP1L |
 Fusion gene summary |
| Fusion gene information | Fusion gene name: PLXNA1_DZIP1L | Fusion gene ID: 27732 | Hgene | Tgene | Gene symbol | PLXNA1 | DZIP1L | Gene ID | 5361 | 199221 |
| Gene name | plexin A1 | DAZ interacting zinc finger protein 1 like | |
| Synonyms | NOV|NOVP|PLEXIN-A1|PLXN1 | DZIP2|PKD5 | |
| Cytomap | 3q21.3 | 3q22.3 | |
| Type of gene | protein-coding | protein-coding | |
| Description | plexin-A1plexin 1semaphorin receptor NOV | zinc finger protein DZIP1LDAZ interacting protein 1-likeDAZ-interacting protein 1-like protein | |
| Modification date | 20180523 | 20180523 | |
| UniProtAcc | Q9UIW2 | Q8IYY4 | |
| Ensembl transtripts involved in fusion gene | ENST00000393409, ENST00000251772, ENST00000505278, | ENST00000327532, ENST00000488595, ENST00000469243, | |
| Fusion gene scores | * DoF score | 4 X 3 X 4=48 | 3 X 3 X 2=18 |
| # samples | 6 | 3 | |
| ** MAII score | log2(6/48*10)=0.321928094887362 effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs). DoF>8 and MAII>0 | log2(3/18*10)=0.736965594166206 effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs). DoF>8 and MAII>0 | |
| Context | PubMed: PLXNA1 [Title/Abstract] AND DZIP1L [Title/Abstract] AND fusion [Title/Abstract] | ||
| Functional or gene categories assigned by FusionGDB annotation | |||
| * DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
| Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Partner | Gene | GO ID | GO term | PubMed ID |
| Fusion gene information from three resources (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| TCGA | RV | PRAD | TCGA-KK-A6E1-01A | PLXNA1 | chr3 | 126708630 | + | DZIP1L | chr3 | 137811386 | - |
| * LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
| Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| In-frame | ENST00000393409 | ENST00000327532 | PLXNA1 | chr3 | 126708630 | + | DZIP1L | chr3 | 137811386 | - |
| 5CDS-intron | ENST00000393409 | ENST00000488595 | PLXNA1 | chr3 | 126708630 | + | DZIP1L | chr3 | 137811386 | - |
| 5CDS-intron | ENST00000393409 | ENST00000469243 | PLXNA1 | chr3 | 126708630 | + | DZIP1L | chr3 | 137811386 | - |
| In-frame | ENST00000251772 | ENST00000327532 | PLXNA1 | chr3 | 126708630 | + | DZIP1L | chr3 | 137811386 | - |
| 5CDS-intron | ENST00000251772 | ENST00000488595 | PLXNA1 | chr3 | 126708630 | + | DZIP1L | chr3 | 137811386 | - |
| 5CDS-intron | ENST00000251772 | ENST00000469243 | PLXNA1 | chr3 | 126708630 | + | DZIP1L | chr3 | 137811386 | - |
| intron-3CDS | ENST00000505278 | ENST00000327532 | PLXNA1 | chr3 | 126708630 | + | DZIP1L | chr3 | 137811386 | - |
| intron-intron | ENST00000505278 | ENST00000488595 | PLXNA1 | chr3 | 126708630 | + | DZIP1L | chr3 | 137811386 | - |
| intron-intron | ENST00000505278 | ENST00000469243 | PLXNA1 | chr3 | 126708630 | + | DZIP1L | chr3 | 137811386 | - |
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FusionProtFeatures for PLXNA1_DZIP1L |
| Main function of each fusion partner protein. (from UniProt) |
| Hgene | Tgene |
| PLXNA1 | DZIP1L |
| Coreceptor for SEMA3A, SEMA3C, SEMA3F and SEMA6D.Necessary for signaling by class 3 semaphorins and subsequentremodeling of the cytoskeleton. Plays a role in axon guidance,invasive growth and cell migration. Class 3 semaphorins bind to acomplex composed of a neuropilin and a plexin. The plexinmodulates the affinity of the complex for specific semaphorins,and its cytoplasmic domain is required for the activation of down-stream signaling events in the cytoplasm (By similarity).{ECO:0000250}. | Involved in primary cilium formation (PubMed:19852954,PubMed:28530676). Probably acts as a transition zone proteinrequired for localization of PKD1/PC1 and PKD2/PC2 to the ciliarymembrane (PubMed:28530676). {ECO:0000269|PubMed:19852954,ECO:0000269|PubMed:28530676}. |
| Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at . * Minus value of BPloci means that the break pointn is located before the CDS. |
| - In-frame and retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
| - In-frame and not-retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
| Hgene | >PLXNA1 | chr3:126708630 | chr3:137811386 | ENST00000393409 | + | 1 | 31 | 1264_1317 | 398 | 1897 | Coiled coil | Ontology_term=ECO:0000255 |
| Hgene | >PLXNA1 | chr3:126708630 | chr3:137811386 | ENST00000393409 | + | 1 | 31 | 1048_1147 | 398 | 1897 | Domain | Note=IPT/TIG 3 |
| Hgene | >PLXNA1 | chr3:126708630 | chr3:137811386 | ENST00000393409 | + | 1 | 31 | 1150_1236 | 398 | 1897 | Domain | Note=IPT/TIG 4 |
| Hgene | >PLXNA1 | chr3:126708630 | chr3:137811386 | ENST00000393409 | + | 1 | 31 | 27_512 | 398 | 1897 | Domain | Sema |
| Hgene | >PLXNA1 | chr3:126708630 | chr3:137811386 | ENST00000393409 | + | 1 | 31 | 864_959 | 398 | 1897 | Domain | Note=IPT/TIG 1 |
| Hgene | >PLXNA1 | chr3:126708630 | chr3:137811386 | ENST00000393409 | + | 1 | 31 | 961_1045 | 398 | 1897 | Domain | Note=IPT/TIG 2 |
| Hgene | >PLXNA1 | chr3:126708630 | chr3:137811386 | ENST00000393409 | + | 1 | 31 | 1266_1896 | 398 | 1897 | Topological domain | Cytoplasmic |
| Hgene | >PLXNA1 | chr3:126708630 | chr3:137811386 | ENST00000393409 | + | 1 | 31 | 27_1244 | 398 | 1897 | Topological domain | Extracellular |
| Hgene | >PLXNA1 | chr3:126708630 | chr3:137811386 | ENST00000393409 | + | 1 | 31 | 1245_1265 | 398 | 1897 | Transmembrane | Helical |
| Tgene | DZIP1L | chr3:126708630 | chr3:137811386 | ENST00000327532 | - | 3 | 16 | 205_406 | 236 | 768 | Coiled coil | Ontology_term=ECO:0000255 |
| Tgene | DZIP1L | chr3:126708630 | chr3:137811386 | ENST00000469243 | - | 4 | 14 | 205_406 | 236 | 540 | Coiled coil | Ontology_term=ECO:0000255 |
| Tgene | DZIP1L | chr3:126708630 | chr3:137811386 | ENST00000327532 | - | 3 | 16 | 166_189 | 236 | 768 | Zinc finger | C2H2-type |
| Tgene | DZIP1L | chr3:126708630 | chr3:137811386 | ENST00000469243 | - | 4 | 14 | 166_189 | 236 | 540 | Zinc finger | C2H2-type |
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FusionGeneSequence for PLXNA1_DZIP1L |
| For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. (nt: nucleotides, aa: amino acids) |
| * Fusion amino acid sequences. |
| >In-frame_PLXNA1_ENST00000393409_chr3_126708630_+_DZIP1L_ENST00000327532_chr3_137811386_-_930aa MPLPPRSLQVLLLLLLLLLLLPGMWAEAGLPRAGGGSQPPFRTFSASDWGLTHLVVHEQTGEVYVGAVNRIYKLSGNLTLLRAHVTGPVE DNEKCYPPPSVQSCPHGLGSTDNVNKLLLLDYAANRLLACGSASQGICQFLRLDDLFKLGEPHHRKEHYLSSVQEAGSMAGVLIAGPPGQ GQAKLFVGTPIDGKSEYFPTLSSRRLMANEEDADMFGFVYQDEFVSSQLKIPSDTLSKFPAFDIYYVYSFRSEQFVYYLTLQLDTQLTSP DAAGEHFFTSKIVRLCVDDPKFYSYVEFPIGCEQAGVEYRLVQDAYLSRPGRALAHQLGLAEDEDVLFTVFAQGQKNRVKPPKESALCLF TLRAIKEKIKERIQSCYRGEGKLSLPWLLNKELGCINSEAELIHQREIEAKKEFDKWKEQEWTKLYGEIDKLKKLFWDEFKNVAKQNSTL EEKLRALQSHSVMESKLGSLRDEESEEWLRQARELQALREKTEIQKTEWKRKVKELHEEHMAEKKELQEENQRLQASLSQDQKKAAAQSQ CQISTLRAQLQEQARIIASQEEMIQSLSLRKVEGIHKVPKAVDTEEDSPEEEMEDSQDEQHKVLAALRRNPTLLKHFRPILEDTLEEKLE SMGIRKDAKGISIQTLRHLESLLRVQREQKARKFSEFLSLRGKLVKEVTSRAKERQENGAVVSQPDGQPSVKSQQSTLVTREAQPKTRTL QVALPSTPAEPPPPTRQSHGSHGSSLTQVSAPAPRPGLHGPSSTPPSSGPGMSTPPFSSEEDSEGDRVQRVSLQPPKVPSRMVPRPKDDW DWSDTETSEENAQPPGQGSGTLVQSMVKNLEKQLEAPAKKPAGGVSLFFMPNAGPQRAATPGRKPQLSEDESDLEISSLEDLPLDLDQRE >In-frame_PLXNA1_ENST00000251772_chr3_126708630_+_DZIP1L_ENST00000327532_chr3_137811386_-_907aa MWAEAGLPRAGGGSQPPFRTFSASDWGLTHLVVHEQTGEVYVGAVNRIYKLSGNLTLLRAHVTGPVEDNEKCYPPPSVQSCPHGLGSTDN VNKLLLLDYAANRLLACGSASQGICQFLRLDDLFKLGEPHHRKEHYLSSVQEAGSMAGVLIAGPPGQGQAKLFVGTPIDGKSEYFPTLSS RRLMANEEDADMFGFVYQDEFVSSQLKIPSDTLSKFPAFDIYYVYSFRSEQFVYYLTLQLDTQLTSPDAAGEHFFTSKIVRLCVDDPKFY SYVEFPIGCEQAGVEYRLVQDAYLSRPGRALAHQLGLAEDEDVLFTVFAQGQKNRVKPPKESALCLFTLRAIKEKIKERIQSCYRGEGKL SLPWLLNKELGCINSEAELIHQREIEAKKEFDKWKEQEWTKLYGEIDKLKKLFWDEFKNVAKQNSTLEEKLRALQSHSVMESKLGSLRDE ESEEWLRQARELQALREKTEIQKTEWKRKVKELHEEHMAEKKELQEENQRLQASLSQDQKKAAAQSQCQISTLRAQLQEQARIIASQEEM IQSLSLRKVEGIHKVPKAVDTEEDSPEEEMEDSQDEQHKVLAALRRNPTLLKHFRPILEDTLEEKLESMGIRKDAKGISIQTLRHLESLL RVQREQKARKFSEFLSLRGKLVKEVTSRAKERQENGAVVSQPDGQPSVKSQQSTLVTREAQPKTRTLQVALPSTPAEPPPPTRQSHGSHG SSLTQVSAPAPRPGLHGPSSTPPSSGPGMSTPPFSSEEDSEGDRVQRVSLQPPKVPSRMVPRPKDDWDWSDTETSEENAQPPGQGSGTLV QSMVKNLEKQLEAPAKKPAGGVSLFFMPNAGPQRAATPGRKPQLSEDESDLEISSLEDLPLDLDQREKPKPLSRSKLPEKFGTGPQSSGQ |
| * Fusion transcript sequences (only coding sequence (CDS) region). |
| >In-frame_PLXNA1_ENST00000393409_chr3_126708630_+_DZIP1L_ENST00000327532_chr3_137811386_-_2790nt ATGCCGCTGCCACCGCGGAGCCTGCAGGTGCTCCTGCTGCTGCTGCTGTTGCTGCTGCTGCTGCCGGGCATGTGGGCTGAGGCAGGCTTG CCCAGGGCAGGCGGGGGTTCACAGCCCCCCTTCCGCACCTTCTCGGCCAGCGACTGGGGCCTCACCCACCTAGTGGTGCATGAGCAGACA GGCGAGGTGTATGTGGGCGCAGTGAACCGCATCTATAAGCTGTCGGGGAACCTGACACTGCTGCGGGCCCACGTCACGGGCCCTGTGGAG GACAACGAGAAGTGCTACCCGCCGCCCAGCGTGCAGTCCTGCCCCCACGGCCTGGGCAGTACTGACAACGTCAACAAGCTGCTGCTGCTG GACTATGCCGCTAACCGCCTGCTGGCCTGTGGCAGCGCCTCCCAGGGCATCTGCCAGTTCCTGCGTCTGGACGATCTCTTCAAACTGGGT GAGCCACACCACCGTAAGGAGCACTACCTGTCCAGCGTGCAGGAGGCAGGCAGCATGGCGGGCGTGCTCATTGCCGGGCCACCGGGCCAG GGCCAGGCCAAGCTCTTCGTGGGCACACCCATCGATGGCAAGTCCGAGTACTTCCCCACACTGTCCAGCCGTCGGCTCATGGCCAACGAG GAGGATGCCGACATGTTCGGCTTCGTGTACCAGGATGAGTTTGTGTCATCACAGCTCAAGATCCCTTCGGACACGCTGTCCAAGTTCCCG GCCTTTGACATCTACTATGTGTACAGCTTCCGCAGCGAGCAGTTTGTCTACTACCTCACGCTGCAGCTAGACACACAGCTGACCTCGCCT GATGCCGCCGGCGAGCACTTCTTCACGTCCAAGATCGTGCGGCTCTGTGTGGACGACCCCAAATTCTACTCGTACGTTGAGTTCCCCATT GGCTGCGAGCAGGCGGGTGTGGAGTACCGCCTGGTGCAGGATGCCTACCTGAGCCGGCCCGGCCGTGCCCTGGCCCACCAGCTGGGCCTG GCTGAGGACGAGGACGTGCTGTTCACTGTGTTCGCCCAGGGCCAGAAGAACCGCGTGAAGCCACCAAAGGAGTCAGCACTGTGCCTGTTC ACGCTCAGGGCCATCAAGGAGAAGATTAAGGAGCGCATCCAGTCCTGCTACCGTGGTGAGGGCAAGCTCTCCCTGCCGTGGCTGCTCAAC AAGGAGCTGGGCTGCATCAACTCGGAAGCAGAGCTCATTCATCAGAGGGAAATAGAAGCTAAGAAAGAATTTGATAAATGGAAAGAGCAA GAGTGGACCAAACTTTATGGGGAAATAGATAAACTAAAAAAATTATTTTGGGATGAATTTAAAAATGTCGCCAAGCAGAACTCTACACTA GAAGAGAAACTGCGGGCACTGCAGTCCCACAGTGTGATGGAGTCCAAGCTGGGATCACTGCGAGATGAGGAGTCAGAGGAGTGGCTTCGG CAGGCACGGGAGCTTCAGGCCCTGAGAGAGAAGACAGAAATTCAGAAAACGGAGTGGAAAAGAAAAGTGAAGGAACTGCATGAAGAGCAC ATGGCTGAGAAGAAAGAGCTACAGGAGGAGAACCAGAGGCTCCAGGCCTCCCTGTCTCAGGATCAGAAGAAGGCAGCTGCCCAGTCCCAG TGCCAGATCAGCACCCTCCGTGCCCAGCTGCAGGAACAAGCTAGGATCATTGCCTCCCAGGAGGAGATGATCCAGTCCTTGTCTCTCAGG AAGGTGGAAGGGATCCACAAGGTGCCAAAGGCTGTGGACACAGAGGAGGACTCTCCAGAGGAAGAGATGGAGGACTCCCAGGATGAACAG CACAAGGTGCTGGCAGCTCTGAGGCGTAACCCCACTTTGCTGAAGCACTTCAGACCAATCCTGGAGGACACCCTGGAAGAGAAGCTCGAA AGCATGGGGATAAGGAAGGATGCAAAGGGAATCTCGATTCAGACTCTCAGACACCTGGAATCCCTGCTGAGAGTCCAGCGGGAGCAGAAG GCCCGGAAGTTTTCTGAATTTCTGAGTCTGAGGGGAAAGCTTGTCAAGGAAGTCACCAGCAGAGCGAAGGAGAGACAGGAGAATGGCGCT GTGGTGTCCCAGCCAGACGGGCAGCCTTCAGTCAAAAGCCAGCAGAGCACACTGGTCACCAGAGAGGCCCAGCCAAAGACCAGGACCCTG CAGGTGGCCTTGCCATCCACACCGGCAGAGCCACCCCCACCAACTCGTCAGAGCCATGGCAGCCATGGCTCCAGCCTGACCCAGGTGTCC GCCCCCGCTCCACGCCCCGGACTGCATGGACCCTCCAGCACCCCTCCTTCCTCGGGGCCCGGGATGAGCACGCCCCCGTTCAGTTCTGAA GAGGACTCAGAGGGAGACCGTGTGCAGCGTGTGTCTCTACAGCCCCCAAAAGTTCCTTCCAGGATGGTGCCCCGGCCCAAGGATGACTGG GACTGGTCTGACACAGAGACCTCGGAGGAGAATGCCCAGCCCCCTGGCCAGGGCTCAGGAACACTGGTGCAGTCGATGGTCAAAAACCTG GAGAAGCAGCTAGAAGCTCCAGCAAAGAAGCCTGCTGGAGGGGTCAGTCTGTTTTTTATGCCCAATGCTGGGCCACAGAGGGCTGCCACA CCAGGAAGGAAGCCTCAGCTTTCTGAAGATGAGAGTGACTTGGAGATCTCCTCCTTGGAAGATCTTCCTCTGGACCTGGACCAGAGAGAG AAACCCAAGCCCTTGTCTCGCTCAAAGCTCCCAGAGAAGTTTGGCACTGGTCCACAGAGCTCTGGCCAACCCAGGGTCCCTGCCTGGTGA >In-frame_PLXNA1_ENST00000251772_chr3_126708630_+_DZIP1L_ENST00000327532_chr3_137811386_-_2721nt ATGTGGGCTGAGGCAGGCTTGCCCAGGGCAGGCGGGGGTTCACAGCCCCCCTTCCGCACCTTCTCGGCCAGCGACTGGGGCCTCACCCAC CTAGTGGTGCATGAGCAGACAGGCGAGGTGTATGTGGGCGCAGTGAACCGCATCTATAAGCTGTCGGGGAACCTGACACTGCTGCGGGCC CACGTCACGGGCCCTGTGGAGGACAACGAGAAGTGCTACCCGCCGCCCAGCGTGCAGTCCTGCCCCCACGGCCTGGGCAGTACTGACAAC GTCAACAAGCTGCTGCTGCTGGACTATGCCGCTAACCGCCTGCTGGCCTGTGGCAGCGCCTCCCAGGGCATCTGCCAGTTCCTGCGTCTG GACGATCTCTTCAAACTGGGTGAGCCACACCACCGTAAGGAGCACTACCTGTCCAGCGTGCAGGAGGCAGGCAGCATGGCGGGCGTGCTC ATTGCCGGGCCACCGGGCCAGGGCCAGGCCAAGCTCTTCGTGGGCACACCCATCGATGGCAAGTCCGAGTACTTCCCCACACTGTCCAGC CGTCGGCTCATGGCCAACGAGGAGGATGCCGACATGTTCGGCTTCGTGTACCAGGATGAGTTTGTGTCATCACAGCTCAAGATCCCTTCG GACACGCTGTCCAAGTTCCCGGCCTTTGACATCTACTATGTGTACAGCTTCCGCAGCGAGCAGTTTGTCTACTACCTCACGCTGCAGCTA GACACACAGCTGACCTCGCCTGATGCCGCCGGCGAGCACTTCTTCACGTCCAAGATCGTGCGGCTCTGTGTGGACGACCCCAAATTCTAC TCGTACGTTGAGTTCCCCATTGGCTGCGAGCAGGCGGGTGTGGAGTACCGCCTGGTGCAGGATGCCTACCTGAGCCGGCCCGGCCGTGCC CTGGCCCACCAGCTGGGCCTGGCTGAGGACGAGGACGTGCTGTTCACTGTGTTCGCCCAGGGCCAGAAGAACCGCGTGAAGCCACCAAAG GAGTCAGCACTGTGCCTGTTCACGCTCAGGGCCATCAAGGAGAAGATTAAGGAGCGCATCCAGTCCTGCTACCGTGGTGAGGGCAAGCTC TCCCTGCCGTGGCTGCTCAACAAGGAGCTGGGCTGCATCAACTCGGAAGCAGAGCTCATTCATCAGAGGGAAATAGAAGCTAAGAAAGAA TTTGATAAATGGAAAGAGCAAGAGTGGACCAAACTTTATGGGGAAATAGATAAACTAAAAAAATTATTTTGGGATGAATTTAAAAATGTC GCCAAGCAGAACTCTACACTAGAAGAGAAACTGCGGGCACTGCAGTCCCACAGTGTGATGGAGTCCAAGCTGGGATCACTGCGAGATGAG GAGTCAGAGGAGTGGCTTCGGCAGGCACGGGAGCTTCAGGCCCTGAGAGAGAAGACAGAAATTCAGAAAACGGAGTGGAAAAGAAAAGTG AAGGAACTGCATGAAGAGCACATGGCTGAGAAGAAAGAGCTACAGGAGGAGAACCAGAGGCTCCAGGCCTCCCTGTCTCAGGATCAGAAG AAGGCAGCTGCCCAGTCCCAGTGCCAGATCAGCACCCTCCGTGCCCAGCTGCAGGAACAAGCTAGGATCATTGCCTCCCAGGAGGAGATG ATCCAGTCCTTGTCTCTCAGGAAGGTGGAAGGGATCCACAAGGTGCCAAAGGCTGTGGACACAGAGGAGGACTCTCCAGAGGAAGAGATG GAGGACTCCCAGGATGAACAGCACAAGGTGCTGGCAGCTCTGAGGCGTAACCCCACTTTGCTGAAGCACTTCAGACCAATCCTGGAGGAC ACCCTGGAAGAGAAGCTCGAAAGCATGGGGATAAGGAAGGATGCAAAGGGAATCTCGATTCAGACTCTCAGACACCTGGAATCCCTGCTG AGAGTCCAGCGGGAGCAGAAGGCCCGGAAGTTTTCTGAATTTCTGAGTCTGAGGGGAAAGCTTGTCAAGGAAGTCACCAGCAGAGCGAAG GAGAGACAGGAGAATGGCGCTGTGGTGTCCCAGCCAGACGGGCAGCCTTCAGTCAAAAGCCAGCAGAGCACACTGGTCACCAGAGAGGCC CAGCCAAAGACCAGGACCCTGCAGGTGGCCTTGCCATCCACACCGGCAGAGCCACCCCCACCAACTCGTCAGAGCCATGGCAGCCATGGC TCCAGCCTGACCCAGGTGTCCGCCCCCGCTCCACGCCCCGGACTGCATGGACCCTCCAGCACCCCTCCTTCCTCGGGGCCCGGGATGAGC ACGCCCCCGTTCAGTTCTGAAGAGGACTCAGAGGGAGACCGTGTGCAGCGTGTGTCTCTACAGCCCCCAAAAGTTCCTTCCAGGATGGTG CCCCGGCCCAAGGATGACTGGGACTGGTCTGACACAGAGACCTCGGAGGAGAATGCCCAGCCCCCTGGCCAGGGCTCAGGAACACTGGTG CAGTCGATGGTCAAAAACCTGGAGAAGCAGCTAGAAGCTCCAGCAAAGAAGCCTGCTGGAGGGGTCAGTCTGTTTTTTATGCCCAATGCT GGGCCACAGAGGGCTGCCACACCAGGAAGGAAGCCTCAGCTTTCTGAAGATGAGAGTGACTTGGAGATCTCCTCCTTGGAAGATCTTCCT CTGGACCTGGACCAGAGAGAGAAACCCAAGCCCTTGTCTCGCTCAAAGCTCCCAGAGAAGTTTGGCACTGGTCCACAGAGCTCTGGCCAA |
| * Fusion transcript sequences (Full-length transcript). |
| >In-frame_PLXNA1_ENST00000393409_chr3_126708630_+_DZIP1L_ENST00000327532_chr3_137811386_-_3616nt ATGCCGCTGCCACCGCGGAGCCTGCAGGTGCTCCTGCTGCTGCTGCTGTTGCTGCTGCTGCTGCCGGGCATGTGGGCTGAGGCAGGCTTG CCCAGGGCAGGCGGGGGTTCACAGCCCCCCTTCCGCACCTTCTCGGCCAGCGACTGGGGCCTCACCCACCTAGTGGTGCATGAGCAGACA GGCGAGGTGTATGTGGGCGCAGTGAACCGCATCTATAAGCTGTCGGGGAACCTGACACTGCTGCGGGCCCACGTCACGGGCCCTGTGGAG GACAACGAGAAGTGCTACCCGCCGCCCAGCGTGCAGTCCTGCCCCCACGGCCTGGGCAGTACTGACAACGTCAACAAGCTGCTGCTGCTG GACTATGCCGCTAACCGCCTGCTGGCCTGTGGCAGCGCCTCCCAGGGCATCTGCCAGTTCCTGCGTCTGGACGATCTCTTCAAACTGGGT GAGCCACACCACCGTAAGGAGCACTACCTGTCCAGCGTGCAGGAGGCAGGCAGCATGGCGGGCGTGCTCATTGCCGGGCCACCGGGCCAG GGCCAGGCCAAGCTCTTCGTGGGCACACCCATCGATGGCAAGTCCGAGTACTTCCCCACACTGTCCAGCCGTCGGCTCATGGCCAACGAG GAGGATGCCGACATGTTCGGCTTCGTGTACCAGGATGAGTTTGTGTCATCACAGCTCAAGATCCCTTCGGACACGCTGTCCAAGTTCCCG GCCTTTGACATCTACTATGTGTACAGCTTCCGCAGCGAGCAGTTTGTCTACTACCTCACGCTGCAGCTAGACACACAGCTGACCTCGCCT GATGCCGCCGGCGAGCACTTCTTCACGTCCAAGATCGTGCGGCTCTGTGTGGACGACCCCAAATTCTACTCGTACGTTGAGTTCCCCATT GGCTGCGAGCAGGCGGGTGTGGAGTACCGCCTGGTGCAGGATGCCTACCTGAGCCGGCCCGGCCGTGCCCTGGCCCACCAGCTGGGCCTG GCTGAGGACGAGGACGTGCTGTTCACTGTGTTCGCCCAGGGCCAGAAGAACCGCGTGAAGCCACCAAAGGAGTCAGCACTGTGCCTGTTC ACGCTCAGGGCCATCAAGGAGAAGATTAAGGAGCGCATCCAGTCCTGCTACCGTGGTGAGGGCAAGCTCTCCCTGCCGTGGCTGCTCAAC AAGGAGCTGGGCTGCATCAACTCGGAAGCAGAGCTCATTCATCAGAGGGAAATAGAAGCTAAGAAAGAATTTGATAAATGGAAAGAGCAA GAGTGGACCAAACTTTATGGGGAAATAGATAAACTAAAAAAATTATTTTGGGATGAATTTAAAAATGTCGCCAAGCAGAACTCTACACTA GAAGAGAAACTGCGGGCACTGCAGTCCCACAGTGTGATGGAGTCCAAGCTGGGATCACTGCGAGATGAGGAGTCAGAGGAGTGGCTTCGG CAGGCACGGGAGCTTCAGGCCCTGAGAGAGAAGACAGAAATTCAGAAAACGGAGTGGAAAAGAAAAGTGAAGGAACTGCATGAAGAGCAC ATGGCTGAGAAGAAAGAGCTACAGGAGGAGAACCAGAGGCTCCAGGCCTCCCTGTCTCAGGATCAGAAGAAGGCAGCTGCCCAGTCCCAG TGCCAGATCAGCACCCTCCGTGCCCAGCTGCAGGAACAAGCTAGGATCATTGCCTCCCAGGAGGAGATGATCCAGTCCTTGTCTCTCAGG AAGGTGGAAGGGATCCACAAGGTGCCAAAGGCTGTGGACACAGAGGAGGACTCTCCAGAGGAAGAGATGGAGGACTCCCAGGATGAACAG CACAAGGTGCTGGCAGCTCTGAGGCGTAACCCCACTTTGCTGAAGCACTTCAGACCAATCCTGGAGGACACCCTGGAAGAGAAGCTCGAA AGCATGGGGATAAGGAAGGATGCAAAGGGAATCTCGATTCAGACTCTCAGACACCTGGAATCCCTGCTGAGAGTCCAGCGGGAGCAGAAG GCCCGGAAGTTTTCTGAATTTCTGAGTCTGAGGGGAAAGCTTGTCAAGGAAGTCACCAGCAGAGCGAAGGAGAGACAGGAGAATGGCGCT GTGGTGTCCCAGCCAGACGGGCAGCCTTCAGTCAAAAGCCAGCAGAGCACACTGGTCACCAGAGAGGCCCAGCCAAAGACCAGGACCCTG CAGGTGGCCTTGCCATCCACACCGGCAGAGCCACCCCCACCAACTCGTCAGAGCCATGGCAGCCATGGCTCCAGCCTGACCCAGGTGTCC GCCCCCGCTCCACGCCCCGGACTGCATGGACCCTCCAGCACCCCTCCTTCCTCGGGGCCCGGGATGAGCACGCCCCCGTTCAGTTCTGAA GAGGACTCAGAGGGAGACCGTGTGCAGCGTGTGTCTCTACAGCCCCCAAAAGTTCCTTCCAGGATGGTGCCCCGGCCCAAGGATGACTGG GACTGGTCTGACACAGAGACCTCGGAGGAGAATGCCCAGCCCCCTGGCCAGGGCTCAGGAACACTGGTGCAGTCGATGGTCAAAAACCTG GAGAAGCAGCTAGAAGCTCCAGCAAAGAAGCCTGCTGGAGGGGTCAGTCTGTTTTTTATGCCCAATGCTGGGCCACAGAGGGCTGCCACA CCAGGAAGGAAGCCTCAGCTTTCTGAAGATGAGAGTGACTTGGAGATCTCCTCCTTGGAAGATCTTCCTCTGGACCTGGACCAGAGAGAG AAACCCAAGCCCTTGTCTCGCTCAAAGCTCCCAGAGAAGTTTGGCACTGGTCCACAGAGCTCTGGCCAACCCAGGGTCCCTGCCTGGTGA TTCACCCCAGAAGCTAGCTGGCTAGAGGGTTAGCCTGGCTGGGGCCAGCTCAGGTCCACTTCAACAGAAGAGGCTGCTGGGCCTCTTGTC TTCACAAACAACCAAGAGATCATCCTCTTGGAGAGAAGCAGTGCAGGGAATGGATATGATCTCATCCCTCCTGACCTGTGAGGGGCCCTG CTGTAGATGGCCACAGGTGCCTGACTAGGAGCCCCTAGGTCCCCAGGCTTGAGAAAGGGTTAAAATAGAACCTCCAGGTAGTTTTCTTCC TCTACCTCCACATCCCCCCAAGACTGAAAAGAGTCACTAACTCTCTTTTCCCAAGCCTTTTATAAAACTGCAGGAACACTGTGGAGATGG TTCCTATCTGGGGTCCTTTTGGGGACATATGCCTCAGTCAGTCATTCAGTGATTGATCCAAAATTATTTACTGAGTGCCTACCTACTCTG CGCCAGGCTCTCTAGCCTCTCACTACTGAGTTAGGGTGCAGGCAGAGGCTGGGGCAGAATGTTTACAGCCAGTGCCAGCACAAGGTAGTA ATCTAGTGACAGAGAACAGGGTGTTATGGGGAGCATATGAGAGGCCATCTATCCCAGCCTGGGTGATCCTGGAGAGTTTCCCAGGGTTGT GATATGTGGCAGGCCTACTCATGGGTGGGAAGGGAGGATGGCCACTTGGCTGGACCTTGTATCCCCAAAGGACCACACGTGTAATTTTTG ATATTATTTCCAAAATCAGGTTTTATACATAGCCATTGTATATTTTTAGTGTGAAAAACATTAATATATTATATGCAAACATTTAAATAT >In-frame_PLXNA1_ENST00000251772_chr3_126708630_+_DZIP1L_ENST00000327532_chr3_137811386_-_3616nt ATGCCGCTGCCACCGCGGAGCCTGCAGGTGCTCCTGCTGCTGCTGCTGTTGCTGCTGCTGCTGCCGGGCATGTGGGCTGAGGCAGGCTTG CCCAGGGCAGGCGGGGGTTCACAGCCCCCCTTCCGCACCTTCTCGGCCAGCGACTGGGGCCTCACCCACCTAGTGGTGCATGAGCAGACA GGCGAGGTGTATGTGGGCGCAGTGAACCGCATCTATAAGCTGTCGGGGAACCTGACACTGCTGCGGGCCCACGTCACGGGCCCTGTGGAG GACAACGAGAAGTGCTACCCGCCGCCCAGCGTGCAGTCCTGCCCCCACGGCCTGGGCAGTACTGACAACGTCAACAAGCTGCTGCTGCTG GACTATGCCGCTAACCGCCTGCTGGCCTGTGGCAGCGCCTCCCAGGGCATCTGCCAGTTCCTGCGTCTGGACGATCTCTTCAAACTGGGT GAGCCACACCACCGTAAGGAGCACTACCTGTCCAGCGTGCAGGAGGCAGGCAGCATGGCGGGCGTGCTCATTGCCGGGCCACCGGGCCAG GGCCAGGCCAAGCTCTTCGTGGGCACACCCATCGATGGCAAGTCCGAGTACTTCCCCACACTGTCCAGCCGTCGGCTCATGGCCAACGAG GAGGATGCCGACATGTTCGGCTTCGTGTACCAGGATGAGTTTGTGTCATCACAGCTCAAGATCCCTTCGGACACGCTGTCCAAGTTCCCG GCCTTTGACATCTACTATGTGTACAGCTTCCGCAGCGAGCAGTTTGTCTACTACCTCACGCTGCAGCTAGACACACAGCTGACCTCGCCT GATGCCGCCGGCGAGCACTTCTTCACGTCCAAGATCGTGCGGCTCTGTGTGGACGACCCCAAATTCTACTCGTACGTTGAGTTCCCCATT GGCTGCGAGCAGGCGGGTGTGGAGTACCGCCTGGTGCAGGATGCCTACCTGAGCCGGCCCGGCCGTGCCCTGGCCCACCAGCTGGGCCTG GCTGAGGACGAGGACGTGCTGTTCACTGTGTTCGCCCAGGGCCAGAAGAACCGCGTGAAGCCACCAAAGGAGTCAGCACTGTGCCTGTTC ACGCTCAGGGCCATCAAGGAGAAGATTAAGGAGCGCATCCAGTCCTGCTACCGTGGTGAGGGCAAGCTCTCCCTGCCGTGGCTGCTCAAC AAGGAGCTGGGCTGCATCAACTCGGAAGCAGAGCTCATTCATCAGAGGGAAATAGAAGCTAAGAAAGAATTTGATAAATGGAAAGAGCAA GAGTGGACCAAACTTTATGGGGAAATAGATAAACTAAAAAAATTATTTTGGGATGAATTTAAAAATGTCGCCAAGCAGAACTCTACACTA GAAGAGAAACTGCGGGCACTGCAGTCCCACAGTGTGATGGAGTCCAAGCTGGGATCACTGCGAGATGAGGAGTCAGAGGAGTGGCTTCGG CAGGCACGGGAGCTTCAGGCCCTGAGAGAGAAGACAGAAATTCAGAAAACGGAGTGGAAAAGAAAAGTGAAGGAACTGCATGAAGAGCAC ATGGCTGAGAAGAAAGAGCTACAGGAGGAGAACCAGAGGCTCCAGGCCTCCCTGTCTCAGGATCAGAAGAAGGCAGCTGCCCAGTCCCAG TGCCAGATCAGCACCCTCCGTGCCCAGCTGCAGGAACAAGCTAGGATCATTGCCTCCCAGGAGGAGATGATCCAGTCCTTGTCTCTCAGG AAGGTGGAAGGGATCCACAAGGTGCCAAAGGCTGTGGACACAGAGGAGGACTCTCCAGAGGAAGAGATGGAGGACTCCCAGGATGAACAG CACAAGGTGCTGGCAGCTCTGAGGCGTAACCCCACTTTGCTGAAGCACTTCAGACCAATCCTGGAGGACACCCTGGAAGAGAAGCTCGAA AGCATGGGGATAAGGAAGGATGCAAAGGGAATCTCGATTCAGACTCTCAGACACCTGGAATCCCTGCTGAGAGTCCAGCGGGAGCAGAAG GCCCGGAAGTTTTCTGAATTTCTGAGTCTGAGGGGAAAGCTTGTCAAGGAAGTCACCAGCAGAGCGAAGGAGAGACAGGAGAATGGCGCT GTGGTGTCCCAGCCAGACGGGCAGCCTTCAGTCAAAAGCCAGCAGAGCACACTGGTCACCAGAGAGGCCCAGCCAAAGACCAGGACCCTG CAGGTGGCCTTGCCATCCACACCGGCAGAGCCACCCCCACCAACTCGTCAGAGCCATGGCAGCCATGGCTCCAGCCTGACCCAGGTGTCC GCCCCCGCTCCACGCCCCGGACTGCATGGACCCTCCAGCACCCCTCCTTCCTCGGGGCCCGGGATGAGCACGCCCCCGTTCAGTTCTGAA GAGGACTCAGAGGGAGACCGTGTGCAGCGTGTGTCTCTACAGCCCCCAAAAGTTCCTTCCAGGATGGTGCCCCGGCCCAAGGATGACTGG GACTGGTCTGACACAGAGACCTCGGAGGAGAATGCCCAGCCCCCTGGCCAGGGCTCAGGAACACTGGTGCAGTCGATGGTCAAAAACCTG GAGAAGCAGCTAGAAGCTCCAGCAAAGAAGCCTGCTGGAGGGGTCAGTCTGTTTTTTATGCCCAATGCTGGGCCACAGAGGGCTGCCACA CCAGGAAGGAAGCCTCAGCTTTCTGAAGATGAGAGTGACTTGGAGATCTCCTCCTTGGAAGATCTTCCTCTGGACCTGGACCAGAGAGAG AAACCCAAGCCCTTGTCTCGCTCAAAGCTCCCAGAGAAGTTTGGCACTGGTCCACAGAGCTCTGGCCAACCCAGGGTCCCTGCCTGGTGA TTCACCCCAGAAGCTAGCTGGCTAGAGGGTTAGCCTGGCTGGGGCCAGCTCAGGTCCACTTCAACAGAAGAGGCTGCTGGGCCTCTTGTC TTCACAAACAACCAAGAGATCATCCTCTTGGAGAGAAGCAGTGCAGGGAATGGATATGATCTCATCCCTCCTGACCTGTGAGGGGCCCTG CTGTAGATGGCCACAGGTGCCTGACTAGGAGCCCCTAGGTCCCCAGGCTTGAGAAAGGGTTAAAATAGAACCTCCAGGTAGTTTTCTTCC TCTACCTCCACATCCCCCCAAGACTGAAAAGAGTCACTAACTCTCTTTTCCCAAGCCTTTTATAAAACTGCAGGAACACTGTGGAGATGG TTCCTATCTGGGGTCCTTTTGGGGACATATGCCTCAGTCAGTCATTCAGTGATTGATCCAAAATTATTTACTGAGTGCCTACCTACTCTG CGCCAGGCTCTCTAGCCTCTCACTACTGAGTTAGGGTGCAGGCAGAGGCTGGGGCAGAATGTTTACAGCCAGTGCCAGCACAAGGTAGTA ATCTAGTGACAGAGAACAGGGTGTTATGGGGAGCATATGAGAGGCCATCTATCCCAGCCTGGGTGATCCTGGAGAGTTTCCCAGGGTTGT GATATGTGGCAGGCCTACTCATGGGTGGGAAGGGAGGATGGCCACTTGGCTGGACCTTGTATCCCCAAAGGACCACACGTGTAATTTTTG ATATTATTTCCAAAATCAGGTTTTATACATAGCCATTGTATATTTTTAGTGTGAAAAACATTAATATATTATATGCAAACATTTAAATAT |
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FusionGenePPI for PLXNA1_DZIP1L |
| Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in . |
| Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160) |
| Hgene | Hgene's interactors | Tgene | Tgene's interactors |
| PLXNA1 | AKT1, PLXNA1, KDR, RHOD, FBXO6, PDIA3, HLA-DRA, TAZ, SUSD4, LGALS9, TMEM25, CANT1, PTCH1, PTPRK, NRP1, GAN, OS9, FAM19A4, ST8SIA4, DEFA5, SCGB1D1, DEFA1, MGAT4C | DZIP1L | APP, DAZ1, CEP76, SPERT |
| - Retained PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
| - Lost PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
| - Retained PPIs, but lost function due to frame-shift fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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RelatedDrugs for PLXNA1_DZIP1L |
| Drugs targeting genes involved in this fusion gene. (DrugBank Version 5.1.0 2018-04-02) |
| Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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RelatedDiseases for PLXNA1_DZIP1L |
| Diseases associated with fusion partners. (DisGeNet 4.0) |
| Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
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