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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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Fusion gene ID: 27715

FusionGeneSummary for PLSCR1_MACROD2

check button Fusion gene summary
Fusion gene informationFusion gene name: PLSCR1_MACROD2
Fusion gene ID: 27715
HgeneTgene
Gene symbol

PLSCR1

MACROD2

Gene ID

5359

140733

Gene namephospholipid scramblase 1MACRO domain containing 2
SynonymsMMTRA1BC20orf133|C2orf133
Cytomap

3q24

20p12.1

Type of geneprotein-codingprotein-coding
Descriptionphospholipid scramblase 1PL scramblase 1ca(2+)-dependent phospholipid scramblase 1erythrocyte phospholipid scramblaseO-acetyl-ADP-ribose deacetylase MACROD2MACRO domain-containing protein 2[Protein ADP-ribosylglutamate] hydrolase
Modification date2018052320180519
UniProtAcc

O15162

A1Z1Q3

Ensembl transtripts involved in fusion geneENST00000342435, ENST00000448205, 
ENST00000487389, ENST00000448787, 
ENST00000484560, 		ENST00000217246, 
ENST00000310348, ENST00000464883, 
ENST00000402914, ENST00000378058, 
ENST00000407045, 
Fusion gene scores* DoF score2 X 2 X 2=819 X 14 X 11=2926
# samples 219
** MAII scorelog2(2/8*10)=1.32192809488736log2(19/2926*10)=-3.94485844580754
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: PLSCR1 [Title/Abstract] AND MACROD2 [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgenePLSCR1

GO:0006915

apoptotic process

10770950

HgenePLSCR1

GO:0017121

phospholipid scrambling

9218461|10770950|18629440

HgenePLSCR1

GO:0045944

positive regulation of transcription by RNA polymerase II

16091359

HgenePLSCR1

GO:2000373

positive regulation of DNA topoisomerase (ATP-hydrolyzing) activity

17567603

TgeneMACROD2

GO:0042278

purine nucleoside metabolic process

21257746

TgeneMACROD2

GO:0051725

protein de-ADP-ribosylation

23474712


check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
TCGARVHNSCTCGA-QK-A6V9-01APLSCR1chr3

146234793

-MACROD2chr20

16021846

+
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
In-frameENST00000342435ENST00000217246PLSCR1chr3

146234793

-MACROD2chr20

16021846

+
In-frameENST00000342435ENST00000310348PLSCR1chr3

146234793

-MACROD2chr20

16021846

+
5CDS-intronENST00000342435ENST00000464883PLSCR1chr3

146234793

-MACROD2chr20

16021846

+
5CDS-intronENST00000342435ENST00000402914PLSCR1chr3

146234793

-MACROD2chr20

16021846

+
5CDS-intronENST00000342435ENST00000378058PLSCR1chr3

146234793

-MACROD2chr20

16021846

+
5CDS-intronENST00000342435ENST00000407045PLSCR1chr3

146234793

-MACROD2chr20

16021846

+
In-frameENST00000448205ENST00000217246PLSCR1chr3

146234793

-MACROD2chr20

16021846

+
In-frameENST00000448205ENST00000310348PLSCR1chr3

146234793

-MACROD2chr20

16021846

+
5CDS-intronENST00000448205ENST00000464883PLSCR1chr3

146234793

-MACROD2chr20

16021846

+
5CDS-intronENST00000448205ENST00000402914PLSCR1chr3

146234793

-MACROD2chr20

16021846

+
5CDS-intronENST00000448205ENST00000378058PLSCR1chr3

146234793

-MACROD2chr20

16021846

+
5CDS-intronENST00000448205ENST00000407045PLSCR1chr3

146234793

-MACROD2chr20

16021846

+
In-frameENST00000487389ENST00000217246PLSCR1chr3

146234793

-MACROD2chr20

16021846

+
In-frameENST00000487389ENST00000310348PLSCR1chr3

146234793

-MACROD2chr20

16021846

+
5CDS-intronENST00000487389ENST00000464883PLSCR1chr3

146234793

-MACROD2chr20

16021846

+
5CDS-intronENST00000487389ENST00000402914PLSCR1chr3

146234793

-MACROD2chr20

16021846

+
5CDS-intronENST00000487389ENST00000378058PLSCR1chr3

146234793

-MACROD2chr20

16021846

+
5CDS-intronENST00000487389ENST00000407045PLSCR1chr3

146234793

-MACROD2chr20

16021846

+
Frame-shiftENST00000448787ENST00000217246PLSCR1chr3

146234793

-MACROD2chr20

16021846

+
Frame-shiftENST00000448787ENST00000310348PLSCR1chr3

146234793

-MACROD2chr20

16021846

+
5CDS-intronENST00000448787ENST00000464883PLSCR1chr3

146234793

-MACROD2chr20

16021846

+
5CDS-intronENST00000448787ENST00000402914PLSCR1chr3

146234793

-MACROD2chr20

16021846

+
5CDS-intronENST00000448787ENST00000378058PLSCR1chr3

146234793

-MACROD2chr20

16021846

+
5CDS-intronENST00000448787ENST00000407045PLSCR1chr3

146234793

-MACROD2chr20

16021846

+
intron-3CDSENST00000484560ENST00000217246PLSCR1chr3

146234793

-MACROD2chr20

16021846

+
intron-3CDSENST00000484560ENST00000310348PLSCR1chr3

146234793

-MACROD2chr20

16021846

+
intron-intronENST00000484560ENST00000464883PLSCR1chr3

146234793

-MACROD2chr20

16021846

+
intron-intronENST00000484560ENST00000402914PLSCR1chr3

146234793

-MACROD2chr20

16021846

+
intron-intronENST00000484560ENST00000378058PLSCR1chr3

146234793

-MACROD2chr20

16021846

+
intron-intronENST00000484560ENST00000407045PLSCR1chr3

146234793

-MACROD2chr20

16021846

+

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FusionProtFeatures for PLSCR1_MACROD2


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
PLSCR1

O15162

MACROD2

A1Z1Q3

May mediate accelerated ATP-independent bidirectionaltransbilayer migration of phospholipids upon binding calcium ionsthat results in a loss of phospholipid asymmetry in the plasmamembrane. May play a central role in the initiation of fibrin clotformation, in the activation of mast cells and in the recognitionof apoptotic and injured cells by the reticuloendothelial system. May play a role in the antiviral response of interferon(IFN) by amplifying and enhancing the IFN response throughincreased expression of select subset of potent antiviral genes.May contribute to cytokine-regulated cell proliferation anddifferentiation. Removes ADP-ribose from glutamate residues in proteinsbearing a single ADP-ribose moiety. Inactive towards proteinsbearing poly-ADP-ribose. Deacetylates O-acetyl-ADP ribose, asignaling molecule generated by the deacetylation of acetylatedlysine residues in histones and other proteins.{ECO:0000269|PubMed:21257746, ECO:0000269|PubMed:23474712}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
>>>>>>>>>>
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgenePLSCR1chr3:146234793chr20:16021846ENST00000342435-89181_189300319Compositional biasNote=Cys-rich
HgenePLSCR1chr3:146234793chr20:16021846ENST00000342435-8918_26300319MotifSH3-binding 1
HgenePLSCR1chr3:146234793chr20:16021846ENST00000342435-8922_25300319MotifPPXY motif 1
HgenePLSCR1chr3:146234793chr20:16021846ENST00000342435-89257_266300319MotifNuclear localization signal
HgenePLSCR1chr3:146234793chr20:16021846ENST00000342435-8933_36300319MotifPPXY motif 2
HgenePLSCR1chr3:146234793chr20:16021846ENST00000342435-8942_50300319MotifSH3-binding 2
HgenePLSCR1chr3:146234793chr20:16021846ENST00000342435-8984_92300319MotifSH3-binding 3
HgenePLSCR1chr3:146234793chr20:16021846ENST00000342435-891_84300319RegionNote=Proline-rich domain (PRD)
HgenePLSCR1chr3:146234793chr20:16021846ENST00000342435-891_288300319Topological domainNote=Cytoplasmic
TgeneMACROD2chr3:146234793chr20:16021846ENST00000378058+610247_388149214Compositional biasNote=Glu-rich
TgeneMACROD2chr3:146234793chr20:16021846ENST00000402914+1014247_388149214Compositional biasNote=Glu-rich
TgeneMACROD2chr3:146234793chr20:16021846ENST00000407045+26247_3883599Compositional biasNote=Glu-rich
TgeneMACROD2chr3:146234793chr20:16021846ENST00000407045+2659_2403599DomainMacro
TgeneMACROD2chr3:146234793chr20:16021846ENST00000378058+610185_191149214RegionNote=Substrate binding
TgeneMACROD2chr3:146234793chr20:16021846ENST00000402914+1014185_191149214RegionNote=Substrate binding
TgeneMACROD2chr3:146234793chr20:16021846ENST00000407045+26185_1913599RegionNote=Substrate binding
TgeneMACROD2chr3:146234793chr20:16021846ENST00000407045+2677_793599RegionNote=Substrate binding
TgeneMACROD2chr3:146234793chr20:16021846ENST00000407045+2690_923599RegionNote=Substrate binding
TgeneMACROD2chr3:146234793chr20:16021846ENST00000407045+2697_1023599RegionNote=Substrate binding

- In-frame and not-retained protein feature among the 13 regional features.
>>
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgenePLSCR1chr3:146234793chr20:16021846ENST00000342435-89306_318300319Topological domainNote=Extracellular
HgenePLSCR1chr3:146234793chr20:16021846ENST00000342435-89289_305300319TransmembraneHelical
TgeneMACROD2chr3:146234793chr20:16021846ENST00000217246+1417247_388384426Compositional biasNote=Glu-rich
TgeneMACROD2chr3:146234793chr20:16021846ENST00000217246+14176_9384426Compositional biasNote=Poly-Lys
TgeneMACROD2chr3:146234793chr20:16021846ENST00000310348+1418247_388384449Compositional biasNote=Glu-rich
TgeneMACROD2chr3:146234793chr20:16021846ENST00000310348+14186_9384449Compositional biasNote=Poly-Lys
TgeneMACROD2chr3:146234793chr20:16021846ENST00000378058+6106_9149214Compositional biasNote=Poly-Lys
TgeneMACROD2chr3:146234793chr20:16021846ENST00000402914+10146_9149214Compositional biasNote=Poly-Lys
TgeneMACROD2chr3:146234793chr20:16021846ENST00000407045+266_93599Compositional biasNote=Poly-Lys
TgeneMACROD2chr3:146234793chr20:16021846ENST00000217246+141759_240384426DomainMacro
TgeneMACROD2chr3:146234793chr20:16021846ENST00000310348+141859_240384449DomainMacro
TgeneMACROD2chr3:146234793chr20:16021846ENST00000378058+61059_240149214DomainMacro
TgeneMACROD2chr3:146234793chr20:16021846ENST00000402914+101459_240149214DomainMacro
TgeneMACROD2chr3:146234793chr20:16021846ENST00000217246+1417185_191384426RegionNote=Substrate binding
TgeneMACROD2chr3:146234793chr20:16021846ENST00000217246+141777_79384426RegionNote=Substrate binding
TgeneMACROD2chr3:146234793chr20:16021846ENST00000217246+141790_92384426RegionNote=Substrate binding
TgeneMACROD2chr3:146234793chr20:16021846ENST00000217246+141797_102384426RegionNote=Substrate binding
TgeneMACROD2chr3:146234793chr20:16021846ENST00000310348+1418185_191384449RegionNote=Substrate binding
TgeneMACROD2chr3:146234793chr20:16021846ENST00000310348+141877_79384449RegionNote=Substrate binding
TgeneMACROD2chr3:146234793chr20:16021846ENST00000310348+141890_92384449RegionNote=Substrate binding
TgeneMACROD2chr3:146234793chr20:16021846ENST00000310348+141897_102384449RegionNote=Substrate binding
TgeneMACROD2chr3:146234793chr20:16021846ENST00000378058+61077_79149214RegionNote=Substrate binding
TgeneMACROD2chr3:146234793chr20:16021846ENST00000378058+61090_92149214RegionNote=Substrate binding
TgeneMACROD2chr3:146234793chr20:16021846ENST00000378058+61097_102149214RegionNote=Substrate binding
TgeneMACROD2chr3:146234793chr20:16021846ENST00000402914+101477_79149214RegionNote=Substrate binding
TgeneMACROD2chr3:146234793chr20:16021846ENST00000402914+101490_92149214RegionNote=Substrate binding
TgeneMACROD2chr3:146234793chr20:16021846ENST00000402914+101497_102149214RegionNote=Substrate binding


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FusionGeneSequence for PLSCR1_MACROD2


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.
>In-frame_PLSCR1_ENST00000342435_chr3_146234793_-_MACROD2_ENST00000217246_chr20_16021846_+_41aa

>In-frame_PLSCR1_ENST00000342435_chr3_146234793_-_MACROD2_ENST00000310348_chr20_16021846_+_64aa

>In-frame_PLSCR1_ENST00000448205_chr3_146234793_-_MACROD2_ENST00000217246_chr20_16021846_+_53aa

>In-frame_PLSCR1_ENST00000448205_chr3_146234793_-_MACROD2_ENST00000310348_chr20_16021846_+_76aa

>In-frame_PLSCR1_ENST00000487389_chr3_146234793_-_MACROD2_ENST00000217246_chr20_16021846_+_41aa

>In-frame_PLSCR1_ENST00000487389_chr3_146234793_-_MACROD2_ENST00000310348_chr20_16021846_+_64aa


* Fusion transcript sequences (only coding sequence (CDS) region).
>In-frame_PLSCR1_ENST00000342435_chr3_146234793_-_MACROD2_ENST00000217246_chr20_16021846_+_125nt
CTCCAGGCGAGGACACACCTAGGATGCCTGGGAAAAGTGAAGGCTCCAGTGACCTAGAAAATACTCCAGGTCCTGATGCAGGGGCACAAG

>In-frame_PLSCR1_ENST00000342435_chr3_146234793_-_MACROD2_ENST00000310348_chr20_16021846_+_194nt
CTCCAGGCGAGGACACACCTAGGATGCCTGGGAAAAGTGAAGGCTCCAGTGACCTAGAAAATACTCCAGGTCCTGATGTTGAAATGAATA
GTCAGGTTGACAAGGTAAATGACCCAACAGAGAGTCAACAAGAAGATCAACTAATAGCAGGGGCACAAGATGAAGCGAAGGAACAAAGAA

>In-frame_PLSCR1_ENST00000448205_chr3_146234793_-_MACROD2_ENST00000217246_chr20_16021846_+_161nt
ATGAAAGCTGTAATGATTGGTGCCTGTTTCCTCATTCTCCAGGCGAGGACACACCTAGGATGCCTGGGAAAAGTGAAGGCTCCAGTGACC

>In-frame_PLSCR1_ENST00000448205_chr3_146234793_-_MACROD2_ENST00000310348_chr20_16021846_+_230nt
ATGAAAGCTGTAATGATTGGTGCCTGTTTCCTCATTCTCCAGGCGAGGACACACCTAGGATGCCTGGGAAAAGTGAAGGCTCCAGTGACC
TAGAAAATACTCCAGGTCCTGATGTTGAAATGAATAGTCAGGTTGACAAGGTAAATGACCCAACAGAGAGTCAACAAGAAGATCAACTAA

>In-frame_PLSCR1_ENST00000487389_chr3_146234793_-_MACROD2_ENST00000217246_chr20_16021846_+_125nt
CTCCAGGCGAGGACACACCTAGGATGCCTGGGAAAAGTGAAGGCTCCAGTGACCTAGAAAATACTCCAGGTCCTGATGCAGGGGCACAAG

>In-frame_PLSCR1_ENST00000487389_chr3_146234793_-_MACROD2_ENST00000310348_chr20_16021846_+_194nt
CTCCAGGCGAGGACACACCTAGGATGCCTGGGAAAAGTGAAGGCTCCAGTGACCTAGAAAATACTCCAGGTCCTGATGTTGAAATGAATA
GTCAGGTTGACAAGGTAAATGACCCAACAGAGAGTCAACAAGAAGATCAACTAATAGCAGGGGCACAAGATGAAGCGAAGGAACAAAGAA


* Fusion transcript sequences (Full-length transcript).
>In-frame_PLSCR1_ENST00000342435_chr3_146234793_-_MACROD2_ENST00000217246_chr20_16021846_+_4757nt
GAGTCCCAGTTCCTCTCCTTAACCACCGGACAAACGTCTCTGGAGTCTCTCCAATGAGCAAGAAAGCAAGTCGGGGGTAGGGGAGGGGCC
TCACACCAGGGGGTGGGCGCAGTCCCTCCTCCAGCTCCTTCACCCTCCAGTAGTCTCGTGGGTCCCCGAGCGCCAGCGCGGGAACCGGGA
AAAGGAAACCGTGTTGTGTACGTAAGATTCAGGAAACGAAACCAGGAGCCGCGGGTGTTGGCGCAAAGGTTACTCCCAGACCCTTTTCCG
GCTGACTTCTGAGAAGGTTGCGCAGCAGCTGTGCCCGGCAGTCTAGAGGCGCAGAAGAGGAAGCCATCGCCTGGCCCCGGCTCTCTGGAC
CTTGTCTCGCTCGGGAGCGGAAACAGCGGCAGCCAGAGAACTGTTTTAATCATGGACAAACAAAACTCACAGATGAATGCTTCTCACCCG
GAAACAAACTTGCCAGTTGGGTATCCTCCTCAGTATCCACCGACAGCATTCCAAGGACCTCCAGGATATAGTGGCTACCCTGGGCCCCAG
GTCAGCTACCCACCCCCACCAGCCGGCCATTCAGGTCCTGGCCCAGCTGGCTTTCCTGTCCCAAATCAGCCAGTGTATAATCAGCCAGTA
TATAATCAGCCAGTTGGAGCTGCAGGGGTACCATGGATGCCAGCGCCACAGCCTCCATTAAACTGTCCACCTGGATTAGAATATTTAAGT
CAGATAGATCAGATACTGATTCATCAGCAAATTGAACTTCTGGAAGTTTTAACAGGTTTTGAAACTAATAACAAATATGAAATTAAGAAC
AGCTTTGGACAGAGGGTTTACTTTGCAGCGGAAGATACTGATTGCTGTACCCGAAATTGCTGTGGGCCATCTAGACCTTTTACCTTGAGG
ATTATTGATAATATGGGTCAAGAAGTCATAACTCTGGAGAGACCACTAAGATGTAGCAGCTGTTGTTGTCCCTGCTGCCTTCAGGAGATA
GAAATCCAAGCTCCTCCTGGTGTACCAATAGGTTATGTTATTCAGACTTGGCACCCATGTCTACCAAAGTTTACAATTCAAAATGAGAAA
AGAGAGGATGTACTAAAAATAAGTGGTCCATGTGTTGTGTGCAGCTGTTGTGGAGATGTTGATTTTGAGATTAAATCTCTTGATGAACAG
TGTGTGGTTGGCAAAATTTCCAAGCACTGGACTGGAATTTTGAGAGAGGCATTTACAGACGCTGATAACTTTGGAATCCAGTTCCCTTTA
GACCTTGATGTTAAAATGAAAGCTGTAATGATTGGTGCCTGTTTCCTCATTCTCCAGGCGAGGACACACCTAGGATGCCTGGGAAAAGTG
AAGGCTCCAGTGACCTAGAAAATACTCCAGGTCCTGATGCAGGGGCACAAGATGAAGCGAAGGAACAAAGAAATGGAACTAAATGACAAT
CCTCAGCATCGCAAGGCCTCTCCTGGCTCTGGGGGAGCTCGGGAAGATAGCAGCACACGCTGTGGAGGAGGGTGGGGGTGGGGGGAAGGC
AAGTCCCATGGAAGGACGGGGAATCCTTTACTCTAATTTCTCCAGCTGCATTTTGTTCCGTTTATCTGCAGAAAAAGAAAGAAAAAAAAG
AAAAAAAAAGTTTCCTTTAATTTGGTGGAGGGACCCATGTTGACGCATCTTTCAGGCATTATCCTTGTAATTTCTGTCTTTTCTCTTACA
ACTTTGCCCCAGGGTCACAGTGGCTTGATTGAACACTCACATGTGTATCCTGGCCCCTGTCTGCTTTCTTGGTTATTTCACAAAGCTGGT
CACACAGTGGTTTATTCAAAGGAAGGGGAGGAAGACAGTGGTTTGATAAGCTGCAGGATAAATTTTAGGAATCAATGAGCCCAGCAGCAG
TATAATCCCCAGACAGAGGAGGCAGGATAGAAAATGGGCAAAAGCCTCGGAAACCACTTGGAAAAGGTCTGGACAATGAGGTGAAAATAT
TTTCTTCAGGGTTCCCAAGGCACAATTTGTTCCAAGTGGCTAATGAGAAATATGGAAGCTGAATTTTTTCCAGAGCAGAGTGCAGAGGCA
TAACAGAAGGGTGGGCCCTGGCAGCCATCTGGGTCTCTTCCTTCCTAACCATGGTGGCAGGTGCATCCTTCTTTGACACTGACTTTCAGC
AGAGCTTACTTGGTTCATGAGGTCTTCACATGGAGACTACCAGCAAGAGGTGACTCTCTGCTGCATAACTGTAAAGGATGGCCCTTTGCT
AGGTGTTACAGTTAAAAGCTAAGAAAAGGGGCAGTGCATTTAGGACCCAAACATATGCCTATGAATATCAAAAGCTCCTCCTGAAATTGC
TGTGAGTTTTCCATAAAAGAATATCCTGTCTTCACCCAAGGCTTGACAGCCCACAGAGTGGTCTCATTTGAAATTACAGGAAATTAGAGC
TTTTGCTTGCAGTTCTGCCTTCCTGGCCTGTGTTTAAATGCTGTCACTTGTTTATGCCAAGTTCAAGGCTGATTCAATGGTTGGTCCCCT
CACCCAGAAAACCCTGAAGGGGAGGATACAGCTCTGAAGGGGGGCAGCAGTACTAAAAACCCAAGATGCCAGTGGTATAGTGGGCACAAG
GGATGGCGACCATGAGGATGCCAGGCATCATCACCAATATCTATCCTAGAGCCAGTATAAGGCCAGATGCCTACTTCCCACAGCCTCCCC
GGGTTCCAAAGTCATGTCATTGTTTTCAGTGGAAACATATCGTTTGTTGCATATCTTCTTAAATCCATCTTCCTTGTAAGGGCTTTAGAA
CTAAAACTTACTTATATTGTTTTTCCTTAACAGAGGGAGAAAAATAGTGGATTATTATTTCTAAAATAAAAGGATGTTCTGCTTTCTAAA
TATCCCATCAAAATCTTCAGTTTTGCACTTTTTTGATGGAAAATTCATCTTATCTTCCTATGACTTTGGTTTTAGCCTTTCTGAATTTGT
TACCCCTTCTGGATGGCTTATTTGATATACTGGAATAGTTAACAAGCTATACTTCAGCATATGCACTATATTCTAACAAATTTTTTTTAA
TAAAATCAAGACATCAGCAAGAATGACATTTACGTGACCTCATAATGTGGGATTATGGCCTTCTGTTGCTATTCCAGTTTGATATGGAAG
CATCTATATCCTCTATTGCCGTTAGATGTTGTTGCTTTTCAGAAAAGTAACGAAAAGGCTCATTTTAAAGAATCCAAGAAACGATGTCAT
CCAAATATTGACAGTTTCTACATTTCATGCCATCTTTATAACTCAATTGAAAGTTGCCGTCATTCTTGTGAAGTATTTGACAAGTGCAAT
CTGCTAGAAGCTCGTTTTTCTTGTGACTCCCAAATGTTAGTGCTACTTAGCCTCAGTAATGAGTTACAGTTGAAAAAAACATGAGGGAAA
CAGAGGGACAGAGATTTTCTAATGAACAATGATGGAAGAGACCTAATGTCCTTGCTAGAAACAGCCAGGATGGAAATTATCCAGCCCTGG
CATTCTCCTTATCATCAATGACAGTCATTTTATTCATTTATTTCAAATGTGGGTGGGCTAGAAGTGGAAGGAGGGAATTCTCTCTGCCTA
AAAATTCTAGAAGAATGAAAGTAATCTTTGTATCCAGGAAACTAAGAGAATGAGGAATAAATATCTTCAGCCCGACTCCTGAATTTGTTT
ATTCTTCCATCTATAATTAGATTGTGTTTTCATTTTTGCTTTGTCATGCTTTTTGGTTGTTATTTGGCTATACAGTTTTATGCTTTAAAA
CAAATGATAAAGTTAATTTCCAATTCAATAGTGAAATATTAACAATCTAACTATAGCCAGATCAAAGACACCTGAACACAGAAAACCTTT
ATTTGCTGGTGCTGCCATTGCACAGGCTGTACAATGAAATAGATTTGAAAAGCTGATTGATTTTCCCGCACATAAATTCTGGATGTCAAT
TTCCAACCAAACTCCAATACAGCTATGTGGCATGAAGAGTTACAGGAGGGAGGGAGGAAAATAGCCCTATGTTAGTCATGTTTGCATACA
GAGGATCAAAGTAGGCCTTCACCATAATAGTTCTAATTAAAATGGTCCTCGCTGTAGGAGAGACAAAGGGGCTTTTCCTCTAGCTGGTAA
CTATTCAGATGATGGACAAGTCTTCTTTCATAAAAGATTACAAAGAAGGCATCCGAATCACTGTCTGTGATACTGGGTCACATATTAATC
ACTGCAGCTAATTGTAAATCTTTCTATGAAACACTGAAAAGCCTCTTTGTGAATTAATACAGTTCTGCTTGATGCACTTGATTTGAAAAG
ACATTTCTCTGTATGTGGCGCATGTCGGCTTTGCTTTGAAAAATAACAAAGTTAGCAGAATATGTTCAATATATTTTCTTGGGGAATAGG
GTTTTTATTACATGATTCATTAAGGATTTGCCTTACCCTGACATTTGTGATATAAAGGAAAATCAGAAAAAAAGTAATTTTCTTGATCAA
GATATGTTTTTACTTAATGCAAATAAATGTAGTCTGTTGCTTGCAAGGAAAAAAAAATGGCTTCTGATATCTGGTATAAACTGCTAAATA
GGATAATACGTGCCTCTTTTGTTAAACCGGCATTTAAATGCTGGACTGCTTCTAAATCTGTTTGTTTCTTTTCATCTGTGCCATACACTA

>In-frame_PLSCR1_ENST00000342435_chr3_146234793_-_MACROD2_ENST00000310348_chr20_16021846_+_1505nt
GAGTCCCAGTTCCTCTCCTTAACCACCGGACAAACGTCTCTGGAGTCTCTCCAATGAGCAAGAAAGCAAGTCGGGGGTAGGGGAGGGGCC
TCACACCAGGGGGTGGGCGCAGTCCCTCCTCCAGCTCCTTCACCCTCCAGTAGTCTCGTGGGTCCCCGAGCGCCAGCGCGGGAACCGGGA
AAAGGAAACCGTGTTGTGTACGTAAGATTCAGGAAACGAAACCAGGAGCCGCGGGTGTTGGCGCAAAGGTTACTCCCAGACCCTTTTCCG
GCTGACTTCTGAGAAGGTTGCGCAGCAGCTGTGCCCGGCAGTCTAGAGGCGCAGAAGAGGAAGCCATCGCCTGGCCCCGGCTCTCTGGAC
CTTGTCTCGCTCGGGAGCGGAAACAGCGGCAGCCAGAGAACTGTTTTAATCATGGACAAACAAAACTCACAGATGAATGCTTCTCACCCG
GAAACAAACTTGCCAGTTGGGTATCCTCCTCAGTATCCACCGACAGCATTCCAAGGACCTCCAGGATATAGTGGCTACCCTGGGCCCCAG
GTCAGCTACCCACCCCCACCAGCCGGCCATTCAGGTCCTGGCCCAGCTGGCTTTCCTGTCCCAAATCAGCCAGTGTATAATCAGCCAGTA
TATAATCAGCCAGTTGGAGCTGCAGGGGTACCATGGATGCCAGCGCCACAGCCTCCATTAAACTGTCCACCTGGATTAGAATATTTAAGT
CAGATAGATCAGATACTGATTCATCAGCAAATTGAACTTCTGGAAGTTTTAACAGGTTTTGAAACTAATAACAAATATGAAATTAAGAAC
AGCTTTGGACAGAGGGTTTACTTTGCAGCGGAAGATACTGATTGCTGTACCCGAAATTGCTGTGGGCCATCTAGACCTTTTACCTTGAGG
ATTATTGATAATATGGGTCAAGAAGTCATAACTCTGGAGAGACCACTAAGATGTAGCAGCTGTTGTTGTCCCTGCTGCCTTCAGGAGATA
GAAATCCAAGCTCCTCCTGGTGTACCAATAGGTTATGTTATTCAGACTTGGCACCCATGTCTACCAAAGTTTACAATTCAAAATGAGAAA
AGAGAGGATGTACTAAAAATAAGTGGTCCATGTGTTGTGTGCAGCTGTTGTGGAGATGTTGATTTTGAGATTAAATCTCTTGATGAACAG
TGTGTGGTTGGCAAAATTTCCAAGCACTGGACTGGAATTTTGAGAGAGGCATTTACAGACGCTGATAACTTTGGAATCCAGTTCCCTTTA
GACCTTGATGTTAAAATGAAAGCTGTAATGATTGGTGCCTGTTTCCTCATTCTCCAGGCGAGGACACACCTAGGATGCCTGGGAAAAGTG
AAGGCTCCAGTGACCTAGAAAATACTCCAGGTCCTGATGTTGAAATGAATAGTCAGGTTGACAAGGTAAATGACCCAACAGAGAGTCAAC

>In-frame_PLSCR1_ENST00000448205_chr3_146234793_-_MACROD2_ENST00000217246_chr20_16021846_+_3909nt
GCCCCGGCTCTCTGGACCTTGTCTCGCTCGGGAGCGGAAACAGCGGCAGCCAGAGCATAAAATACACAAGAGGATTTTTATGGAATGGCT
CCTTGTTACAAGGACCACATAAACCCATTTTGAATTATTCAACCATTGCTGAACTTCTTGAAACTGTTTTAATCATGGACAAACAAAACT
CACAGATGAATGCTTCTCACCCGGAAACAAACTTGCCAGTTGGGTATCCTCCTCAGTATCCACCGACAGCATTCCAAGATAGATCAGATA
CTGATTCATCAGCAAATTGAACTTCTGGAAGATTAAATCTCTTGATGAACAGTGTGTGGTTGGCAAAATTTCCAAGCACTGGACTGGAAT
TTTGAGAGAGGCATTTACAGACGCTGATAACTTTGGAATCCAGTTCCCTTTAGACCTTGATGTTAAAATGAAAGCTGTAATGATTGGTGC
CTGTTTCCTCATTCTCCAGGCGAGGACACACCTAGGATGCCTGGGAAAAGTGAAGGCTCCAGTGACCTAGAAAATACTCCAGGTCCTGAT
GCAGGGGCACAAGATGAAGCGAAGGAACAAAGAAATGGAACTAAATGACAATCCTCAGCATCGCAAGGCCTCTCCTGGCTCTGGGGGAGC
TCGGGAAGATAGCAGCACACGCTGTGGAGGAGGGTGGGGGTGGGGGGAAGGCAAGTCCCATGGAAGGACGGGGAATCCTTTACTCTAATT
TCTCCAGCTGCATTTTGTTCCGTTTATCTGCAGAAAAAGAAAGAAAAAAAAGAAAAAAAAAGTTTCCTTTAATTTGGTGGAGGGACCCAT
GTTGACGCATCTTTCAGGCATTATCCTTGTAATTTCTGTCTTTTCTCTTACAACTTTGCCCCAGGGTCACAGTGGCTTGATTGAACACTC
ACATGTGTATCCTGGCCCCTGTCTGCTTTCTTGGTTATTTCACAAAGCTGGTCACACAGTGGTTTATTCAAAGGAAGGGGAGGAAGACAG
TGGTTTGATAAGCTGCAGGATAAATTTTAGGAATCAATGAGCCCAGCAGCAGTATAATCCCCAGACAGAGGAGGCAGGATAGAAAATGGG
CAAAAGCCTCGGAAACCACTTGGAAAAGGTCTGGACAATGAGGTGAAAATATTTTCTTCAGGGTTCCCAAGGCACAATTTGTTCCAAGTG
GCTAATGAGAAATATGGAAGCTGAATTTTTTCCAGAGCAGAGTGCAGAGGCATAACAGAAGGGTGGGCCCTGGCAGCCATCTGGGTCTCT
TCCTTCCTAACCATGGTGGCAGGTGCATCCTTCTTTGACACTGACTTTCAGCAGAGCTTACTTGGTTCATGAGGTCTTCACATGGAGACT
ACCAGCAAGAGGTGACTCTCTGCTGCATAACTGTAAAGGATGGCCCTTTGCTAGGTGTTACAGTTAAAAGCTAAGAAAAGGGGCAGTGCA
TTTAGGACCCAAACATATGCCTATGAATATCAAAAGCTCCTCCTGAAATTGCTGTGAGTTTTCCATAAAAGAATATCCTGTCTTCACCCA
AGGCTTGACAGCCCACAGAGTGGTCTCATTTGAAATTACAGGAAATTAGAGCTTTTGCTTGCAGTTCTGCCTTCCTGGCCTGTGTTTAAA
TGCTGTCACTTGTTTATGCCAAGTTCAAGGCTGATTCAATGGTTGGTCCCCTCACCCAGAAAACCCTGAAGGGGAGGATACAGCTCTGAA
GGGGGGCAGCAGTACTAAAAACCCAAGATGCCAGTGGTATAGTGGGCACAAGGGATGGCGACCATGAGGATGCCAGGCATCATCACCAAT
ATCTATCCTAGAGCCAGTATAAGGCCAGATGCCTACTTCCCACAGCCTCCCCGGGTTCCAAAGTCATGTCATTGTTTTCAGTGGAAACAT
ATCGTTTGTTGCATATCTTCTTAAATCCATCTTCCTTGTAAGGGCTTTAGAACTAAAACTTACTTATATTGTTTTTCCTTAACAGAGGGA
GAAAAATAGTGGATTATTATTTCTAAAATAAAAGGATGTTCTGCTTTCTAAATATCCCATCAAAATCTTCAGTTTTGCACTTTTTTGATG
GAAAATTCATCTTATCTTCCTATGACTTTGGTTTTAGCCTTTCTGAATTTGTTACCCCTTCTGGATGGCTTATTTGATATACTGGAATAG
TTAACAAGCTATACTTCAGCATATGCACTATATTCTAACAAATTTTTTTTAATAAAATCAAGACATCAGCAAGAATGACATTTACGTGAC
CTCATAATGTGGGATTATGGCCTTCTGTTGCTATTCCAGTTTGATATGGAAGCATCTATATCCTCTATTGCCGTTAGATGTTGTTGCTTT
TCAGAAAAGTAACGAAAAGGCTCATTTTAAAGAATCCAAGAAACGATGTCATCCAAATATTGACAGTTTCTACATTTCATGCCATCTTTA
TAACTCAATTGAAAGTTGCCGTCATTCTTGTGAAGTATTTGACAAGTGCAATCTGCTAGAAGCTCGTTTTTCTTGTGACTCCCAAATGTT
AGTGCTACTTAGCCTCAGTAATGAGTTACAGTTGAAAAAAACATGAGGGAAACAGAGGGACAGAGATTTTCTAATGAACAATGATGGAAG
AGACCTAATGTCCTTGCTAGAAACAGCCAGGATGGAAATTATCCAGCCCTGGCATTCTCCTTATCATCAATGACAGTCATTTTATTCATT
TATTTCAAATGTGGGTGGGCTAGAAGTGGAAGGAGGGAATTCTCTCTGCCTAAAAATTCTAGAAGAATGAAAGTAATCTTTGTATCCAGG
AAACTAAGAGAATGAGGAATAAATATCTTCAGCCCGACTCCTGAATTTGTTTATTCTTCCATCTATAATTAGATTGTGTTTTCATTTTTG
CTTTGTCATGCTTTTTGGTTGTTATTTGGCTATACAGTTTTATGCTTTAAAACAAATGATAAAGTTAATTTCCAATTCAATAGTGAAATA
TTAACAATCTAACTATAGCCAGATCAAAGACACCTGAACACAGAAAACCTTTATTTGCTGGTGCTGCCATTGCACAGGCTGTACAATGAA
ATAGATTTGAAAAGCTGATTGATTTTCCCGCACATAAATTCTGGATGTCAATTTCCAACCAAACTCCAATACAGCTATGTGGCATGAAGA
GTTACAGGAGGGAGGGAGGAAAATAGCCCTATGTTAGTCATGTTTGCATACAGAGGATCAAAGTAGGCCTTCACCATAATAGTTCTAATT
AAAATGGTCCTCGCTGTAGGAGAGACAAAGGGGCTTTTCCTCTAGCTGGTAACTATTCAGATGATGGACAAGTCTTCTTTCATAAAAGAT
TACAAAGAAGGCATCCGAATCACTGTCTGTGATACTGGGTCACATATTAATCACTGCAGCTAATTGTAAATCTTTCTATGAAACACTGAA
AAGCCTCTTTGTGAATTAATACAGTTCTGCTTGATGCACTTGATTTGAAAAGACATTTCTCTGTATGTGGCGCATGTCGGCTTTGCTTTG
AAAAATAACAAAGTTAGCAGAATATGTTCAATATATTTTCTTGGGGAATAGGGTTTTTATTACATGATTCATTAAGGATTTGCCTTACCC
TGACATTTGTGATATAAAGGAAAATCAGAAAAAAAGTAATTTTCTTGATCAAGATATGTTTTTACTTAATGCAAATAAATGTAGTCTGTT
GCTTGCAAGGAAAAAAAAATGGCTTCTGATATCTGGTATAAACTGCTAAATAGGATAATACGTGCCTCTTTTGTTAAACCGGCATTTAAA
TGCTGGACTGCTTCTAAATCTGTTTGTTTCTTTTCATCTGTGCCATACACTAAAAAACAACTGTTGCCTTCATACTATATTTGTTAGAGC

>In-frame_PLSCR1_ENST00000448205_chr3_146234793_-_MACROD2_ENST00000310348_chr20_16021846_+_657nt
GCCCCGGCTCTCTGGACCTTGTCTCGCTCGGGAGCGGAAACAGCGGCAGCCAGAGCATAAAATACACAAGAGGATTTTTATGGAATGGCT
CCTTGTTACAAGGACCACATAAACCCATTTTGAATTATTCAACCATTGCTGAACTTCTTGAAACTGTTTTAATCATGGACAAACAAAACT
CACAGATGAATGCTTCTCACCCGGAAACAAACTTGCCAGTTGGGTATCCTCCTCAGTATCCACCGACAGCATTCCAAGATAGATCAGATA
CTGATTCATCAGCAAATTGAACTTCTGGAAGATTAAATCTCTTGATGAACAGTGTGTGGTTGGCAAAATTTCCAAGCACTGGACTGGAAT
TTTGAGAGAGGCATTTACAGACGCTGATAACTTTGGAATCCAGTTCCCTTTAGACCTTGATGTTAAAATGAAAGCTGTAATGATTGGTGC
CTGTTTCCTCATTCTCCAGGCGAGGACACACCTAGGATGCCTGGGAAAAGTGAAGGCTCCAGTGACCTAGAAAATACTCCAGGTCCTGAT
GTTGAAATGAATAGTCAGGTTGACAAGGTAAATGACCCAACAGAGAGTCAACAAGAAGATCAACTAATAGCAGGGGCACAAGATGAAGCG

>In-frame_PLSCR1_ENST00000487389_chr3_146234793_-_MACROD2_ENST00000217246_chr20_16021846_+_4604nt
CTTCACCCTCCAGTAGTCTCGTGGGTCCCCGAGCGCCAGCGCGGGAACCGGGAAAAGGAAACCGTGTTGTGTACGTAAGATTCAGGAAAC
GAAACCAGGAGCCGCGGGTGTTGGCGCAAAGGTTACTCCCAGACCCTTTTCCGGCTGACTTCTGAGAAGGTTGCGCAGCAGCTGTGCCCG
GCAGTCTAGAGGCGCAGAAGAGGAAGCCATCGCCTGGCCCCGGCTCTCTGGACCTTGTCTCGCTCGGGAGCGGAAACAGCGGCAGCCAGA
GACTCACAGATGAATGCTTCTCACCCGGAAACAAACTTGCCAGTTGGGTATCCTCCTCAGTATCCACCGACAGCATTCCAAGGACCTCCA
GGATATAGTGGCTACCCTGGGCCCCAGGTCAGCTACCCACCCCCACCAGCCGGCCATTCAGGTCCTGGCCCAGCTGGCTTTCCTGTCCCA
AATCAGCCAGTGTATAATCAGCCAGTATATAATCAGCCAGTTGGAGCTGCAGGGGTACCATGGATGCCAGCGCCACAGCCTCCATTAAAC
TGTCCACCTGGATTAGAATATTTAAGTCAGATAGATCAGATACTGATTCATCAGCAAATTGAACTTCTGGAAGTTTTAACAGGTTTTGAA
ACTAATAACAAATATGAAATTAAGAACAGCTTTGGACAGAGGGTTTACTTTGCAGCGGAAGATACTGATTGCTGTACCCGAAATTGCTGT
GGGCCATCTAGACCTTTTACCTTGAGGATTATTGATAATATGGGTCAAGAAGTCATAACTCTGGAGAGACCACTAAGATGTAGCAGCTGT
TGTTGTCCCTGCTGCCTTCAGGAGATAGAAATCCAAGCTCCTCCTGGTGTACCAATAGGTTATGTTATTCAGACTTGGCACCCATGTCTA
CCAAAGTTTACAATTCAAAATGAGAAAAGAGAGGATGTACTAAAAATAAGTGGTCCATGTGTTGTGTGCAGCTGTTGTGGAGATGTTGAT
TTTGAGATTAAATCTCTTGATGAACAGTGTGTGGTTGGCAAAATTTCCAAGCACTGGACTGGAATTTTGAGAGAGGCATTTACAGACGCT
GATAACTTTGGAATCCAGTTCCCTTTAGACCTTGATGTTAAAATGAAAGCTGTAATGATTGGTGCCTGTTTCCTCATTCTCCAGGCGAGG
ACACACCTAGGATGCCTGGGAAAAGTGAAGGCTCCAGTGACCTAGAAAATACTCCAGGTCCTGATGCAGGGGCACAAGATGAAGCGAAGG
AACAAAGAAATGGAACTAAATGACAATCCTCAGCATCGCAAGGCCTCTCCTGGCTCTGGGGGAGCTCGGGAAGATAGCAGCACACGCTGT
GGAGGAGGGTGGGGGTGGGGGGAAGGCAAGTCCCATGGAAGGACGGGGAATCCTTTACTCTAATTTCTCCAGCTGCATTTTGTTCCGTTT
ATCTGCAGAAAAAGAAAGAAAAAAAAGAAAAAAAAAGTTTCCTTTAATTTGGTGGAGGGACCCATGTTGACGCATCTTTCAGGCATTATC
CTTGTAATTTCTGTCTTTTCTCTTACAACTTTGCCCCAGGGTCACAGTGGCTTGATTGAACACTCACATGTGTATCCTGGCCCCTGTCTG
CTTTCTTGGTTATTTCACAAAGCTGGTCACACAGTGGTTTATTCAAAGGAAGGGGAGGAAGACAGTGGTTTGATAAGCTGCAGGATAAAT
TTTAGGAATCAATGAGCCCAGCAGCAGTATAATCCCCAGACAGAGGAGGCAGGATAGAAAATGGGCAAAAGCCTCGGAAACCACTTGGAA
AAGGTCTGGACAATGAGGTGAAAATATTTTCTTCAGGGTTCCCAAGGCACAATTTGTTCCAAGTGGCTAATGAGAAATATGGAAGCTGAA
TTTTTTCCAGAGCAGAGTGCAGAGGCATAACAGAAGGGTGGGCCCTGGCAGCCATCTGGGTCTCTTCCTTCCTAACCATGGTGGCAGGTG
CATCCTTCTTTGACACTGACTTTCAGCAGAGCTTACTTGGTTCATGAGGTCTTCACATGGAGACTACCAGCAAGAGGTGACTCTCTGCTG
CATAACTGTAAAGGATGGCCCTTTGCTAGGTGTTACAGTTAAAAGCTAAGAAAAGGGGCAGTGCATTTAGGACCCAAACATATGCCTATG
AATATCAAAAGCTCCTCCTGAAATTGCTGTGAGTTTTCCATAAAAGAATATCCTGTCTTCACCCAAGGCTTGACAGCCCACAGAGTGGTC
TCATTTGAAATTACAGGAAATTAGAGCTTTTGCTTGCAGTTCTGCCTTCCTGGCCTGTGTTTAAATGCTGTCACTTGTTTATGCCAAGTT
CAAGGCTGATTCAATGGTTGGTCCCCTCACCCAGAAAACCCTGAAGGGGAGGATACAGCTCTGAAGGGGGGCAGCAGTACTAAAAACCCA
AGATGCCAGTGGTATAGTGGGCACAAGGGATGGCGACCATGAGGATGCCAGGCATCATCACCAATATCTATCCTAGAGCCAGTATAAGGC
CAGATGCCTACTTCCCACAGCCTCCCCGGGTTCCAAAGTCATGTCATTGTTTTCAGTGGAAACATATCGTTTGTTGCATATCTTCTTAAA
TCCATCTTCCTTGTAAGGGCTTTAGAACTAAAACTTACTTATATTGTTTTTCCTTAACAGAGGGAGAAAAATAGTGGATTATTATTTCTA
AAATAAAAGGATGTTCTGCTTTCTAAATATCCCATCAAAATCTTCAGTTTTGCACTTTTTTGATGGAAAATTCATCTTATCTTCCTATGA
CTTTGGTTTTAGCCTTTCTGAATTTGTTACCCCTTCTGGATGGCTTATTTGATATACTGGAATAGTTAACAAGCTATACTTCAGCATATG
CACTATATTCTAACAAATTTTTTTTAATAAAATCAAGACATCAGCAAGAATGACATTTACGTGACCTCATAATGTGGGATTATGGCCTTC
TGTTGCTATTCCAGTTTGATATGGAAGCATCTATATCCTCTATTGCCGTTAGATGTTGTTGCTTTTCAGAAAAGTAACGAAAAGGCTCAT
TTTAAAGAATCCAAGAAACGATGTCATCCAAATATTGACAGTTTCTACATTTCATGCCATCTTTATAACTCAATTGAAAGTTGCCGTCAT
TCTTGTGAAGTATTTGACAAGTGCAATCTGCTAGAAGCTCGTTTTTCTTGTGACTCCCAAATGTTAGTGCTACTTAGCCTCAGTAATGAG
TTACAGTTGAAAAAAACATGAGGGAAACAGAGGGACAGAGATTTTCTAATGAACAATGATGGAAGAGACCTAATGTCCTTGCTAGAAACA
GCCAGGATGGAAATTATCCAGCCCTGGCATTCTCCTTATCATCAATGACAGTCATTTTATTCATTTATTTCAAATGTGGGTGGGCTAGAA
GTGGAAGGAGGGAATTCTCTCTGCCTAAAAATTCTAGAAGAATGAAAGTAATCTTTGTATCCAGGAAACTAAGAGAATGAGGAATAAATA
TCTTCAGCCCGACTCCTGAATTTGTTTATTCTTCCATCTATAATTAGATTGTGTTTTCATTTTTGCTTTGTCATGCTTTTTGGTTGTTAT
TTGGCTATACAGTTTTATGCTTTAAAACAAATGATAAAGTTAATTTCCAATTCAATAGTGAAATATTAACAATCTAACTATAGCCAGATC
AAAGACACCTGAACACAGAAAACCTTTATTTGCTGGTGCTGCCATTGCACAGGCTGTACAATGAAATAGATTTGAAAAGCTGATTGATTT
TCCCGCACATAAATTCTGGATGTCAATTTCCAACCAAACTCCAATACAGCTATGTGGCATGAAGAGTTACAGGAGGGAGGGAGGAAAATA
GCCCTATGTTAGTCATGTTTGCATACAGAGGATCAAAGTAGGCCTTCACCATAATAGTTCTAATTAAAATGGTCCTCGCTGTAGGAGAGA
CAAAGGGGCTTTTCCTCTAGCTGGTAACTATTCAGATGATGGACAAGTCTTCTTTCATAAAAGATTACAAAGAAGGCATCCGAATCACTG
TCTGTGATACTGGGTCACATATTAATCACTGCAGCTAATTGTAAATCTTTCTATGAAACACTGAAAAGCCTCTTTGTGAATTAATACAGT
TCTGCTTGATGCACTTGATTTGAAAAGACATTTCTCTGTATGTGGCGCATGTCGGCTTTGCTTTGAAAAATAACAAAGTTAGCAGAATAT
GTTCAATATATTTTCTTGGGGAATAGGGTTTTTATTACATGATTCATTAAGGATTTGCCTTACCCTGACATTTGTGATATAAAGGAAAAT
CAGAAAAAAAGTAATTTTCTTGATCAAGATATGTTTTTACTTAATGCAAATAAATGTAGTCTGTTGCTTGCAAGGAAAAAAAAATGGCTT
CTGATATCTGGTATAAACTGCTAAATAGGATAATACGTGCCTCTTTTGTTAAACCGGCATTTAAATGCTGGACTGCTTCTAAATCTGTTT
GTTTCTTTTCATCTGTGCCATACACTAAAAAACAACTGTTGCCTTCATACTATATTTGTTAGAGCAGAATACAAATAAAATTTGTTTGAG

>In-frame_PLSCR1_ENST00000487389_chr3_146234793_-_MACROD2_ENST00000310348_chr20_16021846_+_1352nt
CTTCACCCTCCAGTAGTCTCGTGGGTCCCCGAGCGCCAGCGCGGGAACCGGGAAAAGGAAACCGTGTTGTGTACGTAAGATTCAGGAAAC
GAAACCAGGAGCCGCGGGTGTTGGCGCAAAGGTTACTCCCAGACCCTTTTCCGGCTGACTTCTGAGAAGGTTGCGCAGCAGCTGTGCCCG
GCAGTCTAGAGGCGCAGAAGAGGAAGCCATCGCCTGGCCCCGGCTCTCTGGACCTTGTCTCGCTCGGGAGCGGAAACAGCGGCAGCCAGA
GACTCACAGATGAATGCTTCTCACCCGGAAACAAACTTGCCAGTTGGGTATCCTCCTCAGTATCCACCGACAGCATTCCAAGGACCTCCA
GGATATAGTGGCTACCCTGGGCCCCAGGTCAGCTACCCACCCCCACCAGCCGGCCATTCAGGTCCTGGCCCAGCTGGCTTTCCTGTCCCA
AATCAGCCAGTGTATAATCAGCCAGTATATAATCAGCCAGTTGGAGCTGCAGGGGTACCATGGATGCCAGCGCCACAGCCTCCATTAAAC
TGTCCACCTGGATTAGAATATTTAAGTCAGATAGATCAGATACTGATTCATCAGCAAATTGAACTTCTGGAAGTTTTAACAGGTTTTGAA
ACTAATAACAAATATGAAATTAAGAACAGCTTTGGACAGAGGGTTTACTTTGCAGCGGAAGATACTGATTGCTGTACCCGAAATTGCTGT
GGGCCATCTAGACCTTTTACCTTGAGGATTATTGATAATATGGGTCAAGAAGTCATAACTCTGGAGAGACCACTAAGATGTAGCAGCTGT
TGTTGTCCCTGCTGCCTTCAGGAGATAGAAATCCAAGCTCCTCCTGGTGTACCAATAGGTTATGTTATTCAGACTTGGCACCCATGTCTA
CCAAAGTTTACAATTCAAAATGAGAAAAGAGAGGATGTACTAAAAATAAGTGGTCCATGTGTTGTGTGCAGCTGTTGTGGAGATGTTGAT
TTTGAGATTAAATCTCTTGATGAACAGTGTGTGGTTGGCAAAATTTCCAAGCACTGGACTGGAATTTTGAGAGAGGCATTTACAGACGCT
GATAACTTTGGAATCCAGTTCCCTTTAGACCTTGATGTTAAAATGAAAGCTGTAATGATTGGTGCCTGTTTCCTCATTCTCCAGGCGAGG
ACACACCTAGGATGCCTGGGAAAAGTGAAGGCTCCAGTGACCTAGAAAATACTCCAGGTCCTGATGTTGAAATGAATAGTCAGGTTGACA
AGGTAAATGACCCAACAGAGAGTCAACAAGAAGATCAACTAATAGCAGGGGCACAAGATGAAGCGAAGGAACAAAGAAATGGAACTAAAT


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FusionGenePPI for PLSCR1_MACROD2


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors
PLSCR1CPSF6, ANXA11, RASD1, CRY1, SLC25A6, PGLS, DTX2, HOXA1, DLK2, SPG7, LASP1, NTN4, YIPF3, LINC00663, PHLDA1, SF1, CCDC33, C10orf54, EFEMP2, NOC4L, GNAI2, KIAA1683, ENKD1, ATG12, NEU4, HOXB6, OGDH, MED15, IP6K2, FBXL18, NECAP2, C10orf10, FAM103A1, PLSCR4, CPSF3L, CRK, PCED1A, KRTAP4-12, GPRIN2, SPRY2, VASP, CDC42EP1, ZNF581, HOXA9, HEY2, PLSCR3, TFG, ADAMTSL4, ILF3, NPDC1, CCER1, ZNF764, EWSR1, EXD3, CNTFR, SMCP, GLRX3, DHRS1, DAZAP2, ZNF638, SLC35A2, ZBTB16, CTBP1-AS2, C10orf62, SRC, SHC1, SLPI, EGFR, MAPK6, CRKL, ATN1, RERE, APP, FRAT1, EP300, FBLN1, RBL1, ADCY7, HRG, PML, NR0B2, MVP, ARNT2, ESR2, KIF1A, PITX1, CTSZ, DOCK2, P2RY6, PKD2, RGS3, SMARCC1, STK16, CHRD, FRS3, DEF6, PRR13, VPS37C, DMRT3, SCNM1, GDPD5, KRTAP9-2, LINC01547, ZNF587, KRTAP4-2, LONRF1, CATSPER1, SPATA8, MGAT5B, ZNF417, LCE4A, BCL6B, TRIM42, LCE2D, LCE3C, KRTAP10-9, KRTAP10-11, KRTAP10-3, KRTAP5-6, KRTAP4-11, LGALS9C, GDE1, FAM134C, CDH1, DDIAS, REEP1, RTN1, CLCC1, BOLA1, REEP5, C12orf49, TMEM128, FAM8A1, FAM107AMACROD2TERF1, TERF2


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for PLSCR1_MACROD2


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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RelatedDiseases for PLSCR1_MACROD2


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
HgenePLSCR1C0021400Influenza1CTD_human
HgenePLSCR1C0023893Liver Cirrhosis, Experimental1CTD_human
TgeneMACROD2C0004352Autistic Disorder1CTD_human
TgeneMACROD2C0023903Liver neoplasms1CTD_human
TgeneMACROD2C0236969Substance-Related Disorders1CTD_human