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Fusion gene ID: 27714 |
FusionGeneSummary for PLS3_HSPH1 |
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Fusion gene information | Fusion gene name: PLS3_HSPH1 | Fusion gene ID: 27714 | Hgene | Tgene | Gene symbol | PLS3 | HSPH1 | Gene ID | 5358 | 10808 |
Gene name | plastin 3 | heat shock protein family H (Hsp110) member 1 | |
Synonyms | BMND18|T-plastin | HSP105|HSP105A|HSP105B|NY-CO-25 | |
Cytomap | Xq23 | 13q12.3 | |
Type of gene | protein-coding | protein-coding | |
Description | plastin-3T fimbrinT plastin | heat shock protein 105 kDaantigen NY-CO-25heat shock 105kDa/110kDa protein 1 | |
Modification date | 20180523 | 20180523 | |
UniProtAcc | P13797 | Q92598 | |
Ensembl transtripts involved in fusion gene | ENST00000355899, ENST00000537301, ENST00000289290, ENST00000420625, ENST00000539310, ENST00000543070, | ENST00000380406, ENST00000380405, ENST00000320027, ENST00000445273, ENST00000429785, | |
Fusion gene scores | * DoF score | 2 X 2 X 2=8 | 5 X 5 X 2=50 |
# samples | 2 | 5 | |
** MAII score | log2(2/8*10)=1.32192809488736 | log2(5/50*10)=0 | |
Context | PubMed: PLS3 [Title/Abstract] AND HSPH1 [Title/Abstract] AND fusion [Title/Abstract] | ||
Functional or gene categories assigned by FusionGDB annotation |
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
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Partner | Gene | GO ID | GO term | PubMed ID |
![]() (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
ChiTaRS3.1 | BQ300629 | PLS3 | chrX | 114871171 | - | HSPH1 | chr13 | 31722190 | - |
* LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
![]() * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
Frame-shift | ENST00000355899 | ENST00000380406 | PLS3 | chrX | 114871171 | - | HSPH1 | chr13 | 31722190 | - |
Frame-shift | ENST00000355899 | ENST00000380405 | PLS3 | chrX | 114871171 | - | HSPH1 | chr13 | 31722190 | - |
Frame-shift | ENST00000355899 | ENST00000320027 | PLS3 | chrX | 114871171 | - | HSPH1 | chr13 | 31722190 | - |
Frame-shift | ENST00000355899 | ENST00000445273 | PLS3 | chrX | 114871171 | - | HSPH1 | chr13 | 31722190 | - |
Frame-shift | ENST00000355899 | ENST00000429785 | PLS3 | chrX | 114871171 | - | HSPH1 | chr13 | 31722190 | - |
Frame-shift | ENST00000537301 | ENST00000380406 | PLS3 | chrX | 114871171 | - | HSPH1 | chr13 | 31722190 | - |
Frame-shift | ENST00000537301 | ENST00000380405 | PLS3 | chrX | 114871171 | - | HSPH1 | chr13 | 31722190 | - |
Frame-shift | ENST00000537301 | ENST00000320027 | PLS3 | chrX | 114871171 | - | HSPH1 | chr13 | 31722190 | - |
Frame-shift | ENST00000537301 | ENST00000445273 | PLS3 | chrX | 114871171 | - | HSPH1 | chr13 | 31722190 | - |
Frame-shift | ENST00000537301 | ENST00000429785 | PLS3 | chrX | 114871171 | - | HSPH1 | chr13 | 31722190 | - |
Frame-shift | ENST00000289290 | ENST00000380406 | PLS3 | chrX | 114871171 | - | HSPH1 | chr13 | 31722190 | - |
Frame-shift | ENST00000289290 | ENST00000380405 | PLS3 | chrX | 114871171 | - | HSPH1 | chr13 | 31722190 | - |
Frame-shift | ENST00000289290 | ENST00000320027 | PLS3 | chrX | 114871171 | - | HSPH1 | chr13 | 31722190 | - |
Frame-shift | ENST00000289290 | ENST00000445273 | PLS3 | chrX | 114871171 | - | HSPH1 | chr13 | 31722190 | - |
Frame-shift | ENST00000289290 | ENST00000429785 | PLS3 | chrX | 114871171 | - | HSPH1 | chr13 | 31722190 | - |
Frame-shift | ENST00000420625 | ENST00000380406 | PLS3 | chrX | 114871171 | - | HSPH1 | chr13 | 31722190 | - |
Frame-shift | ENST00000420625 | ENST00000380405 | PLS3 | chrX | 114871171 | - | HSPH1 | chr13 | 31722190 | - |
Frame-shift | ENST00000420625 | ENST00000320027 | PLS3 | chrX | 114871171 | - | HSPH1 | chr13 | 31722190 | - |
Frame-shift | ENST00000420625 | ENST00000445273 | PLS3 | chrX | 114871171 | - | HSPH1 | chr13 | 31722190 | - |
Frame-shift | ENST00000420625 | ENST00000429785 | PLS3 | chrX | 114871171 | - | HSPH1 | chr13 | 31722190 | - |
Frame-shift | ENST00000539310 | ENST00000380406 | PLS3 | chrX | 114871171 | - | HSPH1 | chr13 | 31722190 | - |
Frame-shift | ENST00000539310 | ENST00000380405 | PLS3 | chrX | 114871171 | - | HSPH1 | chr13 | 31722190 | - |
Frame-shift | ENST00000539310 | ENST00000320027 | PLS3 | chrX | 114871171 | - | HSPH1 | chr13 | 31722190 | - |
Frame-shift | ENST00000539310 | ENST00000445273 | PLS3 | chrX | 114871171 | - | HSPH1 | chr13 | 31722190 | - |
Frame-shift | ENST00000539310 | ENST00000429785 | PLS3 | chrX | 114871171 | - | HSPH1 | chr13 | 31722190 | - |
intron-3CDS | ENST00000543070 | ENST00000380406 | PLS3 | chrX | 114871171 | - | HSPH1 | chr13 | 31722190 | - |
intron-3CDS | ENST00000543070 | ENST00000380405 | PLS3 | chrX | 114871171 | - | HSPH1 | chr13 | 31722190 | - |
intron-3CDS | ENST00000543070 | ENST00000320027 | PLS3 | chrX | 114871171 | - | HSPH1 | chr13 | 31722190 | - |
intron-3CDS | ENST00000543070 | ENST00000445273 | PLS3 | chrX | 114871171 | - | HSPH1 | chr13 | 31722190 | - |
intron-3CDS | ENST00000543070 | ENST00000429785 | PLS3 | chrX | 114871171 | - | HSPH1 | chr13 | 31722190 | - |
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FusionProtFeatures for PLS3_HSPH1 |
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Hgene | Tgene |
PLS3 | HSPH1 |
Actin-bundling protein found in intestinal microvilli,hair cell stereocilia, and fibroblast filopodia. May play a rolein the regulation of bone development. | Acts as a nucleotide-exchange factor (NEF) for chaperoneproteins HSPA1A and HSPA1B, promoting the release of ADP fromHSPA1A/B thereby triggering client/substrate protein release(PubMed:24318877). Prevents the aggregation of denatured proteinsin cells under severe stress, on which the ATP levels decreasemarkedly. Inhibits HSPA8/HSC70 ATPase and chaperone activities (Bysimilarity). {ECO:0000250|UniProtKB:Q60446,ECO:0000250|UniProtKB:Q61699, ECO:0000269|PubMed:24318877}. |
![]() * Minus value of BPloci means that the break pointn is located before the CDS. |
- In-frame and retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
- In-frame and not-retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
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FusionGeneSequence for PLS3_HSPH1 |
![]() (nt: nucleotides, aa: amino acids) |
* Fusion amino acid sequences. |
* Fusion transcript sequences (only coding sequence (CDS) region). |
* Fusion transcript sequences (Full-length transcript). |
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FusionGenePPI for PLS3_HSPH1 |
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Hgene | Hgene's interactors | Tgene | Tgene's interactors |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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RelatedDrugs for PLS3_HSPH1 |
![]() (DrugBank Version 5.1.0 2018-04-02) |
Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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RelatedDiseases for PLS3_HSPH1 |
![]() (DisGeNet 4.0) |
Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
Hgene | PLS3 | C0029408 | Degenerative polyarthritis | 1 | CTD_human |
Tgene | HSPH1 | C0019693 | HIV Infections | 1 | CTD_human |