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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 27708

FusionGeneSummary for PLRG1_SRGAP2B

check button Fusion gene summary
Fusion gene informationFusion gene name: PLRG1_SRGAP2B
Fusion gene ID: 27708
HgeneTgene
Gene symbol

PLRG1

SRGAP2B

Gene ID

5356

647135

Gene namepleiotropic regulator 1SLIT-ROBO Rho GTPase activating protein 2B
SynonymsCwc1|PRL1|PRP46|PRPF46|TANGO4SRGAP2L|SRGAP2P2
Cytomap

4q31.3

1q21.1

Type of geneprotein-codingprotein-coding
Descriptionpleiotropic regulator 1pleiotropic regulator 1 (PRL1 homolog, Arabidopsis)transport and golgi organization 4 homologSLIT-ROBO Rho GTPase-activating protein 2BSLIT-ROBO Rho GTPase activating protein 2 pseudogene 2SLIT-ROBO Rho GTPase activating protein 2B (pseudogene)
Modification date2018052320180523
UniProtAcc

O43660

Ensembl transtripts involved in fusion geneENST00000499023, ENST00000393905, 
ENST00000302078, 
ENST00000467933, 
Fusion gene scores* DoF score2 X 3 X 2=124 X 4 X 2=32
# samples 34
** MAII scorelog2(3/12*10)=1.32192809488736
effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs).
DoF>8 and MAII>0
log2(4/32*10)=0.321928094887362
effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs).
DoF>8 and MAII>0
Context

PubMed: PLRG1 [Title/Abstract] AND SRGAP2B [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgenePLRG1

GO:0000398

mRNA splicing, via spliceosome

28076346


check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
TCGALDUCECTCGA-B5-A1MS-01BPLRG1chr4

155471452

-SRGAP2Bchr1

144013901

-
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
5CDS-3UTRENST00000499023ENST00000467933PLRG1chr4

155471452

-SRGAP2Bchr1

144013901

-
intron-3UTRENST00000393905ENST00000467933PLRG1chr4

155471452

-SRGAP2Bchr1

144013901

-
5CDS-3UTRENST00000302078ENST00000467933PLRG1chr4

155471452

-SRGAP2Bchr1

144013901

-

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FusionProtFeatures for PLRG1_SRGAP2B


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
PLRG1

O43660

SRGAP2B

Involved in pre-mRNA splicing as component of thespliceosome (PubMed:28502770, PubMed:28076346). Component of thePRP19-CDC5L complex that forms an integral part of the spliceosomeand is required for activating pre-mRNA splicing (PubMed:11101529,PubMed:11544257). {ECO:0000269|PubMed:11101529,ECO:0000269|PubMed:11544257, ECO:0000269|PubMed:28076346,ECO:0000269|PubMed:28502770}. Lectin that binds to various sugars: galactose > mannose= fucose > N-acetylglucosamine > N-acetylgalactosamine(PubMed:10224141). Acts as a chemoattractant, probably involved inthe regulation of cell migration (PubMed:28301481).{ECO:0000269|PubMed:10224141, ECO:0000269|PubMed:28301481}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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FusionGeneSequence for PLRG1_SRGAP2B


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for PLRG1_SRGAP2B


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors
PLRG1PRPF19, CDC5L, BCAS2, CPVL, USP42, ZSCAN1, SRRM1, CTNNBL1, KPNA2, KPNA1, TADA2A, SF3A2, CUL3, U2AF2, CWC15, USB1, APP, PRPF4, XAB2, RBM39, ISY1, SNRPA1, SF3A1, ZCRB1, RBM14, UCHL5, RPL9, MDC1, EIF4A3, MAGOH, SF3B1, CSNK2A2, SUZ12, BMI1, CCDC94, HNRNPM, NTRK1, AP2M1, ISY1-RAB43, MRPL40, PDIA5, PABPC1, PABPC4, PCF11, PRPF3, PRPF8, SF3A3, SF3B3, SNRPD2, SNW1, MX1, SCARNA22, IFI16, XPO1, BACH1, LINS, CWF19L2, CRNKL1, AQR, DHX35, GPATCH1, SYF2, PPIE, AAR2, CD2BP2, EAPP, TSSC4, DLST, PDHA1, RNF157SRGAP2B


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for PLRG1_SRGAP2B


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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RelatedDiseases for PLRG1_SRGAP2B


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource