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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 27703

FusionGeneSummary for PLP1_SGK1

check button Fusion gene summary
Fusion gene informationFusion gene name: PLP1_SGK1
Fusion gene ID: 27703
HgeneTgene
Gene symbol

PLP1

SGK1

Gene ID

5354

6446

Gene nameproteolipid protein 1serum/glucocorticoid regulated kinase 1
SynonymsGPM6C|HLD1|MMPL|PLP|PLP/DM20|PMD|SPG2SGK
Cytomap

Xq22.2

6q23.2

Type of geneprotein-codingprotein-coding
Descriptionmyelin proteolipid proteinlipophilinmajor myelin proteolipid proteinserine/threonine-protein kinase Sgk1Sgk1 variant i3serine/threonine protein kinase SGK
Modification date2018052320180523
UniProtAcc

P60201

O00141

Ensembl transtripts involved in fusion geneENST00000418604, ENST00000303958, 
ENST00000361621, ENST00000466486, 
ENST00000367858, ENST00000524929, 
ENST00000413996, ENST00000237305, 
ENST00000367857, ENST00000528577, 
ENST00000475719, ENST00000489458, 
Fusion gene scores* DoF score4 X 4 X 2=327 X 7 X 5=245
# samples 49
** MAII scorelog2(4/32*10)=0.321928094887362
effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs).
DoF>8 and MAII>0		log2(9/245*10)=-1.4447848426729
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: PLP1 [Title/Abstract] AND SGK1 [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID

check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
TCGARVLGGTCGA-HT-7902-01APLP1chrX

103047545

+SGK1chr6

134639049

-
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
5CDS-5UTRENST00000418604ENST00000367858PLP1chrX

103047545

+SGK1chr6

134639049

-
5CDS-intronENST00000418604ENST00000524929PLP1chrX

103047545

+SGK1chr6

134639049

-
5CDS-intronENST00000418604ENST00000413996PLP1chrX

103047545

+SGK1chr6

134639049

-
5CDS-intronENST00000418604ENST00000237305PLP1chrX

103047545

+SGK1chr6

134639049

-
5CDS-intronENST00000418604ENST00000367857PLP1chrX

103047545

+SGK1chr6

134639049

-
5CDS-intronENST00000418604ENST00000528577PLP1chrX

103047545

+SGK1chr6

134639049

-
5CDS-intronENST00000418604ENST00000475719PLP1chrX

103047545

+SGK1chr6

134639049

-
5CDS-intronENST00000418604ENST00000489458PLP1chrX

103047545

+SGK1chr6

134639049

-
5CDS-5UTRENST00000303958ENST00000367858PLP1chrX

103047545

+SGK1chr6

134639049

-
5CDS-intronENST00000303958ENST00000524929PLP1chrX

103047545

+SGK1chr6

134639049

-
5CDS-intronENST00000303958ENST00000413996PLP1chrX

103047545

+SGK1chr6

134639049

-
5CDS-intronENST00000303958ENST00000237305PLP1chrX

103047545

+SGK1chr6

134639049

-
5CDS-intronENST00000303958ENST00000367857PLP1chrX

103047545

+SGK1chr6

134639049

-
5CDS-intronENST00000303958ENST00000528577PLP1chrX

103047545

+SGK1chr6

134639049

-
5CDS-intronENST00000303958ENST00000475719PLP1chrX

103047545

+SGK1chr6

134639049

-
5CDS-intronENST00000303958ENST00000489458PLP1chrX

103047545

+SGK1chr6

134639049

-
5CDS-5UTRENST00000361621ENST00000367858PLP1chrX

103047545

+SGK1chr6

134639049

-
5CDS-intronENST00000361621ENST00000524929PLP1chrX

103047545

+SGK1chr6

134639049

-
5CDS-intronENST00000361621ENST00000413996PLP1chrX

103047545

+SGK1chr6

134639049

-
5CDS-intronENST00000361621ENST00000237305PLP1chrX

103047545

+SGK1chr6

134639049

-
5CDS-intronENST00000361621ENST00000367857PLP1chrX

103047545

+SGK1chr6

134639049

-
5CDS-intronENST00000361621ENST00000528577PLP1chrX

103047545

+SGK1chr6

134639049

-
5CDS-intronENST00000361621ENST00000475719PLP1chrX

103047545

+SGK1chr6

134639049

-
5CDS-intronENST00000361621ENST00000489458PLP1chrX

103047545

+SGK1chr6

134639049

-
intron-5UTRENST00000466486ENST00000367858PLP1chrX

103047545

+SGK1chr6

134639049

-
intron-intronENST00000466486ENST00000524929PLP1chrX

103047545

+SGK1chr6

134639049

-
intron-intronENST00000466486ENST00000413996PLP1chrX

103047545

+SGK1chr6

134639049

-
intron-intronENST00000466486ENST00000237305PLP1chrX

103047545

+SGK1chr6

134639049

-
intron-intronENST00000466486ENST00000367857PLP1chrX

103047545

+SGK1chr6

134639049

-
intron-intronENST00000466486ENST00000528577PLP1chrX

103047545

+SGK1chr6

134639049

-
intron-intronENST00000466486ENST00000475719PLP1chrX

103047545

+SGK1chr6

134639049

-
intron-intronENST00000466486ENST00000489458PLP1chrX

103047545

+SGK1chr6

134639049

-

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FusionProtFeatures for PLP1_SGK1


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
PLP1

P60201

SGK1

O00141

This is the major myelin protein from the centralnervous system. It plays an important role in the formation ormaintenance of the multilamellar structure of myelin.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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FusionGeneSequence for PLP1_SGK1


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for PLP1_SGK1


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors
PLP1MBP, ITGAV, CLN8, PTPRN, ITGB5, CALR, AKT1, REEP6, FGFR1OP2, SLMAP, REEP5, STRN, SIKE1, C4orf32, RTN2, STRN4, PDDC1, STRIP1, RNF114, NRAS, LMNASGK1CDC37, LTF, TUFM, CD40, VCP, IGHA1, IARS, PA2G4, PIGR, FANCA, NEDD4, KPNA2, CAMKK2, MAPK7, SLC9A3R2, PDPK1, CARHSP1, PIK3CA, PPP2CA, MLLT3, IKBKG, PDK1, RICTOR, SYVN1, STUB1, TSC22D3, RAF1, COMMD1, SCNN1B, ELAVL1, HSPA4, NEDD4L, WNK4, WNK1, WNK2, MAPT, UBC, HSP90AA1, MAGEA1, GADD45G, TMEM184C, RABAC1, YWHAZ, YWHAQ, MTOR, RPTOR, AKT1S1, CDKN1B, NDRG1, SGK1, ARL5B, MYH14, FKBP5, RAP2A, PCCA, PIN1, ASPG, HRAS, MAPKAP1, TRIM25


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for PLP1_SGK1


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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RelatedDiseases for PLP1_SGK1


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
HgenePLP1C0205711Pelizaeus-Merzbacher Disease31CTD_human;HPO;UNIPROT
HgenePLP1C1839264SPASTIC PARAPLEGIA 2, X-LINKED (disorder)9CTD_human;ORPHANET;UNIPROT
HgenePLP1C0036341Schizophrenia4PSYGENET
HgenePLP1C0009171Cocaine Abuse2PSYGENET
HgenePLP1C2673482Increased susceptibility to schizophrenia1PSYGENET
TgeneSGK1C0011882Diabetic Neuropathies1CTD_human
TgeneSGK1C0023467Leukemia, Myelocytic, Acute1CTD_human
TgeneSGK1C0024667Animal Mammary Neoplasms1CTD_human
TgeneSGK1C0024668Mammary Neoplasms, Experimental1CTD_human
TgeneSGK1C0041696Unipolar Depression1PSYGENET
TgeneSGK1C0041948Uremia1CTD_human
TgeneSGK1C1269683Major Depressive Disorder1PSYGENET