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Fusion gene ID: 27700 |
FusionGeneSummary for PLP1_GNPAT |
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Fusion gene information | Fusion gene name: PLP1_GNPAT | Fusion gene ID: 27700 | Hgene | Tgene | Gene symbol | PLP1 | GNPAT | Gene ID | 5354 | 8443 |
Gene name | proteolipid protein 1 | glyceronephosphate O-acyltransferase | |
Synonyms | GPM6C|HLD1|MMPL|PLP|PLP/DM20|PMD|SPG2 | DAP-AT|DAPAT|DHAPAT|RCDP2 | |
Cytomap | Xq22.2 | 1q42.2 | |
Type of gene | protein-coding | protein-coding | |
Description | myelin proteolipid proteinlipophilinmajor myelin proteolipid protein | dihydroxyacetone phosphate acyltransferaseDHAP-ATacyl-CoA:dihydroxyacetonephosphateacyltransferaseglycerone-phosphate O-acyltransferase | |
Modification date | 20180523 | 20180523 | |
UniProtAcc | P60201 | O15228 | |
Ensembl transtripts involved in fusion gene | ENST00000418604, ENST00000303958, ENST00000361621, ENST00000466486, | ENST00000366647, ENST00000366646, ENST00000469332, | |
Fusion gene scores | * DoF score | 4 X 4 X 2=32 | 4 X 4 X 2=32 |
# samples | 4 | 4 | |
** MAII score | log2(4/32*10)=0.321928094887362 effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs). DoF>8 and MAII>0 | log2(4/32*10)=0.321928094887362 effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs). DoF>8 and MAII>0 | |
Context | PubMed: PLP1 [Title/Abstract] AND GNPAT [Title/Abstract] AND fusion [Title/Abstract] | ||
Functional or gene categories assigned by FusionGDB annotation |
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
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Partner | Gene | GO ID | GO term | PubMed ID |
Tgene | GNPAT | GO:0008611 | ether lipid biosynthetic process | 15687349 |
![]() (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
ChiTaRS3.1 | DA174856 | PLP1 | chrX | 103031891 | + | GNPAT | chr1 | 231410993 | + |
* LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
![]() * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
5UTR-3CDS | ENST00000418604 | ENST00000366647 | PLP1 | chrX | 103031891 | + | GNPAT | chr1 | 231410993 | + |
5UTR-3CDS | ENST00000418604 | ENST00000366646 | PLP1 | chrX | 103031891 | + | GNPAT | chr1 | 231410993 | + |
5UTR-3UTR | ENST00000418604 | ENST00000469332 | PLP1 | chrX | 103031891 | + | GNPAT | chr1 | 231410993 | + |
5UTR-3CDS | ENST00000303958 | ENST00000366647 | PLP1 | chrX | 103031891 | + | GNPAT | chr1 | 231410993 | + |
5UTR-3CDS | ENST00000303958 | ENST00000366646 | PLP1 | chrX | 103031891 | + | GNPAT | chr1 | 231410993 | + |
5UTR-3UTR | ENST00000303958 | ENST00000469332 | PLP1 | chrX | 103031891 | + | GNPAT | chr1 | 231410993 | + |
5UTR-3CDS | ENST00000361621 | ENST00000366647 | PLP1 | chrX | 103031891 | + | GNPAT | chr1 | 231410993 | + |
5UTR-3CDS | ENST00000361621 | ENST00000366646 | PLP1 | chrX | 103031891 | + | GNPAT | chr1 | 231410993 | + |
5UTR-3UTR | ENST00000361621 | ENST00000469332 | PLP1 | chrX | 103031891 | + | GNPAT | chr1 | 231410993 | + |
intron-3CDS | ENST00000466486 | ENST00000366647 | PLP1 | chrX | 103031891 | + | GNPAT | chr1 | 231410993 | + |
intron-3CDS | ENST00000466486 | ENST00000366646 | PLP1 | chrX | 103031891 | + | GNPAT | chr1 | 231410993 | + |
intron-3UTR | ENST00000466486 | ENST00000469332 | PLP1 | chrX | 103031891 | + | GNPAT | chr1 | 231410993 | + |
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FusionProtFeatures for PLP1_GNPAT |
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Hgene | Tgene |
PLP1 | GNPAT |
This is the major myelin protein from the centralnervous system. It plays an important role in the formation ormaintenance of the multilamellar structure of myelin. |
![]() * Minus value of BPloci means that the break pointn is located before the CDS. |
- In-frame and retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
- In-frame and not-retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
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FusionGeneSequence for PLP1_GNPAT |
![]() (nt: nucleotides, aa: amino acids) |
* Fusion amino acid sequences. |
* Fusion transcript sequences (only coding sequence (CDS) region). |
* Fusion transcript sequences (Full-length transcript). |
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FusionGenePPI for PLP1_GNPAT |
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Hgene | Hgene's interactors | Tgene | Tgene's interactors |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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RelatedDrugs for PLP1_GNPAT |
![]() (DrugBank Version 5.1.0 2018-04-02) |
Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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RelatedDiseases for PLP1_GNPAT |
![]() (DisGeNet 4.0) |
Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
Hgene | PLP1 | C0205711 | Pelizaeus-Merzbacher Disease | 31 | CTD_human;HPO;UNIPROT |
Hgene | PLP1 | C1839264 | SPASTIC PARAPLEGIA 2, X-LINKED (disorder) | 9 | CTD_human;ORPHANET;UNIPROT |
Hgene | PLP1 | C0036341 | Schizophrenia | 4 | PSYGENET |
Hgene | PLP1 | C0009171 | Cocaine Abuse | 2 | PSYGENET |
Hgene | PLP1 | C2673482 | Increased susceptibility to schizophrenia | 1 | PSYGENET |
Tgene | GNPAT | C1857242 | Rhizomelic chondrodysplasia punctata, type 2 | 2 | CTD_human;ORPHANET;UNIPROT |
Tgene | GNPAT | C0036341 | Schizophrenia | 1 | PSYGENET |