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Fusion gene ID: 27695 |
FusionGeneSummary for PLOD2_PLOD2 |
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Fusion gene information | Fusion gene name: PLOD2_PLOD2 | Fusion gene ID: 27695 | Hgene | Tgene | Gene symbol | PLOD2 | PLOD2 | Gene ID | 5352 | 5352 |
Gene name | procollagen-lysine,2-oxoglutarate 5-dioxygenase 2 | procollagen-lysine,2-oxoglutarate 5-dioxygenase 2 | |
Synonyms | BRKS2|LH2|TLH | BRKS2|LH2|TLH | |
Cytomap | 3q24 | 3q24 | |
Type of gene | protein-coding | protein-coding | |
Description | procollagen-lysine,2-oxoglutarate 5-dioxygenase 2lysine hydroxylase 2lysyl hydroxlase 2lysyl hydroxylase 2procollagen-lysine 5-dioxygenasetelopeptide lysyl hydroxylase | procollagen-lysine,2-oxoglutarate 5-dioxygenase 2lysine hydroxylase 2lysyl hydroxlase 2lysyl hydroxylase 2procollagen-lysine 5-dioxygenasetelopeptide lysyl hydroxylase | |
Modification date | 20180523 | 20180523 | |
UniProtAcc | O00469 | O00469 | |
Ensembl transtripts involved in fusion gene | ENST00000461497, ENST00000282903, ENST00000360060, ENST00000494950, | ENST00000461497, ENST00000282903, ENST00000360060, ENST00000494950, | |
Fusion gene scores | * DoF score | 2 X 2 X 2=8 | 1 X 1 X 1=1 |
# samples | 2 | 1 | |
** MAII score | log2(2/8*10)=1.32192809488736 | log2(1/1*10)=3.32192809488736 | |
Context | PubMed: PLOD2 [Title/Abstract] AND PLOD2 [Title/Abstract] AND fusion [Title/Abstract] | ||
Functional or gene categories assigned by FusionGDB annotation |
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
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Partner | Gene | GO ID | GO term | PubMed ID |
Hgene | PLOD2 | GO:0006493 | protein O-linked glycosylation | 10934207 |
Hgene | PLOD2 | GO:0017185 | peptidyl-lysine hydroxylation | 10934207 |
Hgene | PLOD2 | GO:0046947 | hydroxylysine biosynthetic process | 10934207 |
Tgene | PLOD2 | GO:0006493 | protein O-linked glycosylation | 10934207 |
Tgene | PLOD2 | GO:0017185 | peptidyl-lysine hydroxylation | 10934207 |
Tgene | PLOD2 | GO:0046947 | hydroxylysine biosynthetic process | 10934207 |
![]() (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
ChiTaRS3.1 | AA503462 | PLOD2 | chr3 | 145787424 | - | PLOD2 | chr3 | 145787802 | + |
* LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
![]() * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
intron-3UTR | ENST00000461497 | ENST00000461497 | PLOD2 | chr3 | 145787424 | - | PLOD2 | chr3 | 145787802 | + |
intron-3UTR | ENST00000461497 | ENST00000282903 | PLOD2 | chr3 | 145787424 | - | PLOD2 | chr3 | 145787802 | + |
intron-3UTR | ENST00000461497 | ENST00000360060 | PLOD2 | chr3 | 145787424 | - | PLOD2 | chr3 | 145787802 | + |
intron-intron | ENST00000461497 | ENST00000494950 | PLOD2 | chr3 | 145787424 | - | PLOD2 | chr3 | 145787802 | + |
intron-3UTR | ENST00000282903 | ENST00000461497 | PLOD2 | chr3 | 145787424 | - | PLOD2 | chr3 | 145787802 | + |
intron-3UTR | ENST00000282903 | ENST00000282903 | PLOD2 | chr3 | 145787424 | - | PLOD2 | chr3 | 145787802 | + |
intron-3UTR | ENST00000282903 | ENST00000360060 | PLOD2 | chr3 | 145787424 | - | PLOD2 | chr3 | 145787802 | + |
intron-intron | ENST00000282903 | ENST00000494950 | PLOD2 | chr3 | 145787424 | - | PLOD2 | chr3 | 145787802 | + |
intron-3UTR | ENST00000360060 | ENST00000461497 | PLOD2 | chr3 | 145787424 | - | PLOD2 | chr3 | 145787802 | + |
intron-3UTR | ENST00000360060 | ENST00000282903 | PLOD2 | chr3 | 145787424 | - | PLOD2 | chr3 | 145787802 | + |
intron-3UTR | ENST00000360060 | ENST00000360060 | PLOD2 | chr3 | 145787424 | - | PLOD2 | chr3 | 145787802 | + |
intron-intron | ENST00000360060 | ENST00000494950 | PLOD2 | chr3 | 145787424 | - | PLOD2 | chr3 | 145787802 | + |
intron-3UTR | ENST00000494950 | ENST00000461497 | PLOD2 | chr3 | 145787424 | - | PLOD2 | chr3 | 145787802 | + |
intron-3UTR | ENST00000494950 | ENST00000282903 | PLOD2 | chr3 | 145787424 | - | PLOD2 | chr3 | 145787802 | + |
intron-3UTR | ENST00000494950 | ENST00000360060 | PLOD2 | chr3 | 145787424 | - | PLOD2 | chr3 | 145787802 | + |
intron-intron | ENST00000494950 | ENST00000494950 | PLOD2 | chr3 | 145787424 | - | PLOD2 | chr3 | 145787802 | + |
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FusionProtFeatures for PLOD2_PLOD2 |
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Hgene | Tgene |
PLOD2 | PLOD2 |
Forms hydroxylysine residues in -Xaa-Lys-Gly- sequencesin collagens. These hydroxylysines serve as sites of attachmentfor carbohydrate units and are essential for the stability of theintermolecular collagen cross-links.{ECO:0000250|UniProtKB:P24802}. | Forms hydroxylysine residues in -Xaa-Lys-Gly- sequencesin collagens. These hydroxylysines serve as sites of attachmentfor carbohydrate units and are essential for the stability of theintermolecular collagen cross-links.{ECO:0000250|UniProtKB:P24802}. |
![]() * Minus value of BPloci means that the break pointn is located before the CDS. |
- In-frame and retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
- In-frame and not-retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
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FusionGeneSequence for PLOD2_PLOD2 |
![]() (nt: nucleotides, aa: amino acids) |
* Fusion amino acid sequences. |
* Fusion transcript sequences (only coding sequence (CDS) region). |
* Fusion transcript sequences (Full-length transcript). |
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FusionGenePPI for PLOD2_PLOD2 |
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Hgene | Hgene's interactors | Tgene | Tgene's interactors |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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RelatedDrugs for PLOD2_PLOD2 |
![]() (DrugBank Version 5.1.0 2018-04-02) |
Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
Hgene | PLOD2 | O00469 | DB00126 | Vitamin C | Procollagen-lysine,2-oxoglutarate 5-dioxygenase 2 | small molecule | approved|nutraceutical |
Tgene | PLOD2 | O00469 | DB00126 | Vitamin C | Procollagen-lysine,2-oxoglutarate 5-dioxygenase 2 | small molecule | approved|nutraceutical |
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RelatedDiseases for PLOD2_PLOD2 |
![]() (DisGeNet 4.0) |
Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
Hgene | PLOD2 | C1836602 | Bruck syndrome 2 | 2 | CTD_human;UNIPROT |
Hgene | PLOD2 | C0005967 | Bone neoplasms | 1 | CTD_human |
Hgene | PLOD2 | C0023890 | Liver Cirrhosis | 1 | CTD_human |
Hgene | PLOD2 | C0023893 | Liver Cirrhosis, Experimental | 1 | CTD_human |
Hgene | PLOD2 | C0029408 | Degenerative polyarthritis | 1 | CTD_human |
Hgene | PLOD2 | C3495559 | Juvenile arthritis | 1 | CTD_human |
Tgene | PLOD2 | C1836602 | Bruck syndrome 2 | 2 | CTD_human;UNIPROT |
Tgene | PLOD2 | C0005967 | Bone neoplasms | 1 | CTD_human |
Tgene | PLOD2 | C0023890 | Liver Cirrhosis | 1 | CTD_human |
Tgene | PLOD2 | C0023893 | Liver Cirrhosis, Experimental | 1 | CTD_human |
Tgene | PLOD2 | C0029408 | Degenerative polyarthritis | 1 | CTD_human |
Tgene | PLOD2 | C3495559 | Juvenile arthritis | 1 | CTD_human |