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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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Fusion gene ID: 27676

FusionGeneSummary for PLEKHS1_PDCD4

check button Fusion gene summary
Fusion gene informationFusion gene name: PLEKHS1_PDCD4
Fusion gene ID: 27676
HgeneTgene
Gene symbol

PLEKHS1

PDCD4

Gene ID

79949

27250

Gene namepleckstrin homology domain containing S1programmed cell death 4
SynonymsC10orf81|HEL185|bA211N11.2H731
Cytomap

10q25.3

10q25.2

Type of geneprotein-codingprotein-coding
Descriptionpleckstrin homology domain-containing family S member 1PH domain-containing family S member 1PH domain-containing protein C10orf81epididymis luminal protein 185programmed cell death protein 4neoplastic transformation inhibitor proteinnuclear antigen H731programmed cell death 4 (neoplastic transformation inhibitor)protein 197/15a
Modification date2018051920180527
UniProtAcc

Q5SXH7

Q53EL6

Ensembl transtripts involved in fusion geneENST00000361048, ENST00000369312, 
ENST00000369310, ENST00000369309, 
ENST00000354462, 
ENST00000280154, 
ENST00000393104, ENST00000481353, 
Fusion gene scores* DoF score2 X 1 X 2=43 X 3 X 2=18
# samples 23
** MAII scorelog2(2/4*10)=2.32192809488736log2(3/18*10)=0.736965594166206
effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs).
DoF>8 and MAII>0
Context

PubMed: PLEKHS1 [Title/Abstract] AND PDCD4 [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotationOncogene involved fusion gene, in-frame and retained their domain.
Tumor suppressor gene involved fusion gene, in-frame but not retained their domain.
Tumor suppressor gene involved fusion gene, retained protein feature but frameshift.
DDR (DNA damage repair) gene involved fusion gene, in-frame but not retained their domain.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
TgenePDCD4

GO:0007569

cell aging

12054647

TgenePDCD4

GO:0030509

BMP signaling pathway

18548003

TgenePDCD4

GO:0045892

negative regulation of transcription, DNA-templated

16357133

TgenePDCD4

GO:1905064

negative regulation of vascular smooth muscle cell differentiation

18548003


check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
TCGALDBRCATCGA-BH-A42U-01APLEKHS1chr10

115529659

+PDCD4chr10

112645011

+
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
In-frameENST00000361048ENST00000280154PLEKHS1chr10

115529659

+PDCD4chr10

112645011

+
In-frameENST00000361048ENST00000393104PLEKHS1chr10

115529659

+PDCD4chr10

112645011

+
5CDS-3UTRENST00000361048ENST00000481353PLEKHS1chr10

115529659

+PDCD4chr10

112645011

+
In-frameENST00000369312ENST00000280154PLEKHS1chr10

115529659

+PDCD4chr10

112645011

+
In-frameENST00000369312ENST00000393104PLEKHS1chr10

115529659

+PDCD4chr10

112645011

+
5CDS-3UTRENST00000369312ENST00000481353PLEKHS1chr10

115529659

+PDCD4chr10

112645011

+
In-frameENST00000369310ENST00000280154PLEKHS1chr10

115529659

+PDCD4chr10

112645011

+
In-frameENST00000369310ENST00000393104PLEKHS1chr10

115529659

+PDCD4chr10

112645011

+
5CDS-3UTRENST00000369310ENST00000481353PLEKHS1chr10

115529659

+PDCD4chr10

112645011

+
intron-3CDSENST00000369309ENST00000280154PLEKHS1chr10

115529659

+PDCD4chr10

112645011

+
intron-3CDSENST00000369309ENST00000393104PLEKHS1chr10

115529659

+PDCD4chr10

112645011

+
intron-3UTRENST00000369309ENST00000481353PLEKHS1chr10

115529659

+PDCD4chr10

112645011

+
intron-3CDSENST00000354462ENST00000280154PLEKHS1chr10

115529659

+PDCD4chr10

112645011

+
intron-3CDSENST00000354462ENST00000393104PLEKHS1chr10

115529659

+PDCD4chr10

112645011

+
intron-3UTRENST00000354462ENST00000481353PLEKHS1chr10

115529659

+PDCD4chr10

112645011

+

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FusionProtFeatures for PLEKHS1_PDCD4


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
PLEKHS1

Q5SXH7

PDCD4

Q53EL6

Inhibits translation initiation and cap-dependenttranslation. May excert its function by hindering the interactionbetween EIF4A1 and EIF4G. Inhibits the helicase activity of EIF4A.Modulates the activation of JUN kinase. Down-regulates theexpression of MAP4K1, thus inhibiting events important in drivinginvasion, namely, MAPK85 activation and consequent JUN-dependenttranscription. May play a role in apoptosis. Tumor suppressor.Inhibits tumor promoter-induced neoplastic transformation. BindsRNA (By similarity). {ECO:0000250, ECO:0000269|PubMed:16357133,ECO:0000269|PubMed:16449643, ECO:0000269|PubMed:17053147,ECO:0000269|PubMed:18296639, ECO:0000269|PubMed:19153607,ECO:0000269|PubMed:19204291}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
>>>>>>
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgenePLEKHS1chr10:115529659chr10:112645011ENST00000361048+71214_129184364DomainPH
HgenePLEKHS1chr10:115529659chr10:112645011ENST00000369310+61214_129178466DomainPH
TgenePDCD4chr10:115529659chr10:112645011ENST00000280154+312163_284147470DomainMI 1
TgenePDCD4chr10:115529659chr10:112645011ENST00000280154+312326_449147470DomainMI 2
TgenePDCD4chr10:115529659chr10:112645011ENST00000393104+413163_284136459DomainMI 1
TgenePDCD4chr10:115529659chr10:112645011ENST00000393104+413326_449136459DomainMI 2
TgenePDCD4chr10:115529659chr10:112645011ENST00000280154+312241_250147470MotifNuclear localization signal
TgenePDCD4chr10:115529659chr10:112645011ENST00000393104+413241_250136459MotifNuclear localization signal

- In-frame and not-retained protein feature among the 13 regional features.
>>
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgenePLEKHS1chr10:115529659chr10:112645011ENST00000354462+1614_129-53199DomainPH
HgenePLEKHS1chr10:115529659chr10:112645011ENST00000369312+71314_12996367DomainPH
TgenePDCD4chr10:115529659chr10:112645011ENST00000280154+31258_64147470MotifNuclear localization signal
TgenePDCD4chr10:115529659chr10:112645011ENST00000280154+31270_76147470MotifNote=Phosphodegron
TgenePDCD4chr10:115529659chr10:112645011ENST00000393104+41358_64136459MotifNuclear localization signal
TgenePDCD4chr10:115529659chr10:112645011ENST00000393104+41370_76136459MotifNote=Phosphodegron


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FusionGeneSequence for PLEKHS1_PDCD4


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.
>In-frame_PLEKHS1_ENST00000361048_chr10_115529659_+_PDCD4_ENST00000280154_chr10_112645011_+_507aa
MEPKPQKSPGKQFTFSYENEVCKQDYFIKSPPSQLFSSVTSWKKRFFILSKAGEKSFSLSYYKDHHHRGSIEIDQNSSVEVGISSQEKMQ
SVQKMFKCHPDEVMSIRTTNREYFLIGHDREKIKDWVSFMSSFRQDIKATQQNTEEELSLGNKRTLFYSSPLLGPSSTSEAVGSSSPRNG
LQDKENCVYETVVLPLDERAFEKTLTPIIQEYFEHGDTNEVAEMLRDLNLGEMKSGVPVLAVSLALEGKASHREMTSKLLSDLCGTVMST
TDVEKSFDKLLKDLPELALDTPRAPQLVGQFIARAVGDGILCNTYIDSYKGTVDCVQARAALDKATVLLSMSKGGKRKDSVWGSGGGQQS
VNHLVKEIDMLLKEYLLSGDISEAEHCLKELEVPHFHHELVYEAIIMVLESTGESTFKMILDLLKSLWKSSTITVDQMKRGYERIYNEIP

>In-frame_PLEKHS1_ENST00000361048_chr10_115529659_+_PDCD4_ENST00000393104_chr10_112645011_+_507aa
MEPKPQKSPGKQFTFSYENEVCKQDYFIKSPPSQLFSSVTSWKKRFFILSKAGEKSFSLSYYKDHHHRGSIEIDQNSSVEVGISSQEKMQ
SVQKMFKCHPDEVMSIRTTNREYFLIGHDREKIKDWVSFMSSFRQDIKATQQNTEEELSLGNKRTLFYSSPLLGPSSTSEAVGSSSPRNG
LQDKENCVYETVVLPLDERAFEKTLTPIIQEYFEHGDTNEVAEMLRDLNLGEMKSGVPVLAVSLALEGKASHREMTSKLLSDLCGTVMST
TDVEKSFDKLLKDLPELALDTPRAPQLVGQFIARAVGDGILCNTYIDSYKGTVDCVQARAALDKATVLLSMSKGGKRKDSVWGSGGGQQS
VNHLVKEIDMLLKEYLLSGDISEAEHCLKELEVPHFHHELVYEAIIMVLESTGESTFKMILDLLKSLWKSSTITVDQMKRGYERIYNEIP

>In-frame_PLEKHS1_ENST00000369312_chr10_115529659_+_PDCD4_ENST00000280154_chr10_112645011_+_419aa
MQSVQKMFKCHPDEVMSIRTTNREYFLIGHDREKIKDWVSFMSSFRQDIKATQQNTEEELSLGNKRTLFYSSPLLGPSSTSEAVGSSSPR
NGLQDKENCVYETVVLPLDERAFEKTLTPIIQEYFEHGDTNEVAEMLRDLNLGEMKSGVPVLAVSLALEGKASHREMTSKLLSDLCGTVM
STTDVEKSFDKLLKDLPELALDTPRAPQLVGQFIARAVGDGILCNTYIDSYKGTVDCVQARAALDKATVLLSMSKGGKRKDSVWGSGGGQ
QSVNHLVKEIDMLLKEYLLSGDISEAEHCLKELEVPHFHHELVYEAIIMVLESTGESTFKMILDLLKSLWKSSTITVDQMKRGYERIYNE

>In-frame_PLEKHS1_ENST00000369312_chr10_115529659_+_PDCD4_ENST00000393104_chr10_112645011_+_419aa
MQSVQKMFKCHPDEVMSIRTTNREYFLIGHDREKIKDWVSFMSSFRQDIKATQQNTEEELSLGNKRTLFYSSPLLGPSSTSEAVGSSSPR
NGLQDKENCVYETVVLPLDERAFEKTLTPIIQEYFEHGDTNEVAEMLRDLNLGEMKSGVPVLAVSLALEGKASHREMTSKLLSDLCGTVM
STTDVEKSFDKLLKDLPELALDTPRAPQLVGQFIARAVGDGILCNTYIDSYKGTVDCVQARAALDKATVLLSMSKGGKRKDSVWGSGGGQ
QSVNHLVKEIDMLLKEYLLSGDISEAEHCLKELEVPHFHHELVYEAIIMVLESTGESTFKMILDLLKSLWKSSTITVDQMKRGYERIYNE

>In-frame_PLEKHS1_ENST00000369310_chr10_115529659_+_PDCD4_ENST00000280154_chr10_112645011_+_501aa
MAGGKQFTFSYENEVCKQDYFIKSPPSQLFSSVTSWKKRFFILSKAGEKSFSLSYYKDHHHRGSIEIDQNSSVEVGISSQEKMQSVQKMF
KCHPDEVMSIRTTNREYFLIGHDREKIKDWVSFMSSFRQDIKATQQNTEEELSLGNKRTLFYSSPLLGPSSTSEAVGSSSPRNGLQDKEN
CVYETVVLPLDERAFEKTLTPIIQEYFEHGDTNEVAEMLRDLNLGEMKSGVPVLAVSLALEGKASHREMTSKLLSDLCGTVMSTTDVEKS
FDKLLKDLPELALDTPRAPQLVGQFIARAVGDGILCNTYIDSYKGTVDCVQARAALDKATVLLSMSKGGKRKDSVWGSGGGQQSVNHLVK
EIDMLLKEYLLSGDISEAEHCLKELEVPHFHHELVYEAIIMVLESTGESTFKMILDLLKSLWKSSTITVDQMKRGYERIYNEIPDINLDV

>In-frame_PLEKHS1_ENST00000369310_chr10_115529659_+_PDCD4_ENST00000393104_chr10_112645011_+_501aa
MAGGKQFTFSYENEVCKQDYFIKSPPSQLFSSVTSWKKRFFILSKAGEKSFSLSYYKDHHHRGSIEIDQNSSVEVGISSQEKMQSVQKMF
KCHPDEVMSIRTTNREYFLIGHDREKIKDWVSFMSSFRQDIKATQQNTEEELSLGNKRTLFYSSPLLGPSSTSEAVGSSSPRNGLQDKEN
CVYETVVLPLDERAFEKTLTPIIQEYFEHGDTNEVAEMLRDLNLGEMKSGVPVLAVSLALEGKASHREMTSKLLSDLCGTVMSTTDVEKS
FDKLLKDLPELALDTPRAPQLVGQFIARAVGDGILCNTYIDSYKGTVDCVQARAALDKATVLLSMSKGGKRKDSVWGSGGGQQSVNHLVK
EIDMLLKEYLLSGDISEAEHCLKELEVPHFHHELVYEAIIMVLESTGESTFKMILDLLKSLWKSSTITVDQMKRGYERIYNEIPDINLDV


* Fusion transcript sequences (only coding sequence (CDS) region).
>In-frame_PLEKHS1_ENST00000361048_chr10_115529659_+_PDCD4_ENST00000280154_chr10_112645011_+_1521nt
ATGGAACCCAAACCTCAGAAGAGTCCAGGCAAACAATTTACATTTTCTTATGAAAATGAAGTCTGCAAACAAGATTACTTTATTAAATCA
CCACCTTCTCAGCTGTTCTCCTCTGTGACCTCTTGGAAAAAGCGGTTTTTCATCCTGTCAAAGGCTGGGGAAAAGAGCTTTAGTCTTTCC
TATTATAAAGACCATCATCACCGAGGTTCCATTGAAATTGATCAAAATTCCAGTGTAGAAGTTGGCATAAGTAGCCAGGAAAAGATGCAA
TCTGTGCAGAAGATGTTTAAATGCCACCCTGATGAGGTCATGTCCATCAGAACCACTAACAGGGAATACTTCCTCATTGGCCACGACAGG
GAGAAGATTAAAGACTGGGTCTCCTTCATGTCATCATTTCGCCAGGATATAAAAGCAACACAGCAGAACACAGAGGAGGAACTCTCATTG
GGTAATAAAAGAACCCTCTTCTACTCCAGCCCTCTCCTTGGCCCTTCCAGCACATCAGAGGCTGTTGGCTCCAGCTCACCAAGAAATGGT
CTCCAAGACAAGGAGAACTGTGTTTATGAAACTGTAGTTTTGCCTTTGGATGAAAGGGCATTTGAGAAGACTTTAACACCAATCATACAG
GAATATTTTGAGCATGGAGATACTAATGAAGTTGCGGAAATGTTAAGAGATTTAAATCTTGGTGAAATGAAAAGTGGAGTACCAGTGTTG
GCAGTATCCTTAGCATTGGAGGGGAAGGCTAGTCATAGAGAGATGACATCTAAGCTTCTTTCTGACCTTTGTGGGACAGTAATGAGCACA
ACTGATGTGGAAAAATCATTTGATAAATTGTTGAAAGATCTACCTGAATTAGCACTGGATACTCCTAGAGCACCACAGTTGGTGGGCCAG
TTTATTGCTAGAGCTGTTGGAGATGGAATTTTATGTAATACCTATATTGATAGTTACAAAGGAACTGTAGATTGTGTGCAGGCTAGAGCT
GCTCTGGATAAGGCTACCGTGCTTCTGAGTATGTCTAAAGGTGGAAAGCGTAAAGATAGTGTGTGGGGCTCTGGAGGTGGGCAGCAATCT
GTCAATCACCTTGTTAAAGAGATTGATATGCTGCTGAAAGAATATTTACTCTCTGGAGACATATCTGAAGCTGAACATTGCCTTAAGGAA
CTGGAAGTACCTCATTTTCACCATGAGCTTGTATATGAAGCTATTATAATGGTTTTAGAGTCAACTGGAGAAAGTACATTTAAGATGATT
TTGGATTTATTAAAGTCCCTTTGGAAGTCTTCTACCATTACTGTAGACCAAATGAAAAGAGGTTATGAGAGAATTTACAATGAAATTCCG
GACATTAATCTGGATGTCCCACATTCATACTCTGTGCTGGAGCGGTTTGTAGAAGAATGTTTTCAGGCTGGAATAATTTCCAAACAACTC

>In-frame_PLEKHS1_ENST00000361048_chr10_115529659_+_PDCD4_ENST00000393104_chr10_112645011_+_1521nt
ATGGAACCCAAACCTCAGAAGAGTCCAGGCAAACAATTTACATTTTCTTATGAAAATGAAGTCTGCAAACAAGATTACTTTATTAAATCA
CCACCTTCTCAGCTGTTCTCCTCTGTGACCTCTTGGAAAAAGCGGTTTTTCATCCTGTCAAAGGCTGGGGAAAAGAGCTTTAGTCTTTCC
TATTATAAAGACCATCATCACCGAGGTTCCATTGAAATTGATCAAAATTCCAGTGTAGAAGTTGGCATAAGTAGCCAGGAAAAGATGCAA
TCTGTGCAGAAGATGTTTAAATGCCACCCTGATGAGGTCATGTCCATCAGAACCACTAACAGGGAATACTTCCTCATTGGCCACGACAGG
GAGAAGATTAAAGACTGGGTCTCCTTCATGTCATCATTTCGCCAGGATATAAAAGCAACACAGCAGAACACAGAGGAGGAACTCTCATTG
GGTAATAAAAGAACCCTCTTCTACTCCAGCCCTCTCCTTGGCCCTTCCAGCACATCAGAGGCTGTTGGCTCCAGCTCACCAAGAAATGGT
CTCCAAGACAAGGAGAACTGTGTTTATGAAACTGTAGTTTTGCCTTTGGATGAAAGGGCATTTGAGAAGACTTTAACACCAATCATACAG
GAATATTTTGAGCATGGAGATACTAATGAAGTTGCGGAAATGTTAAGAGATTTAAATCTTGGTGAAATGAAAAGTGGAGTACCAGTGTTG
GCAGTATCCTTAGCATTGGAGGGGAAGGCTAGTCATAGAGAGATGACATCTAAGCTTCTTTCTGACCTTTGTGGGACAGTAATGAGCACA
ACTGATGTGGAAAAATCATTTGATAAATTGTTGAAAGATCTACCTGAATTAGCACTGGATACTCCTAGAGCACCACAGTTGGTGGGCCAG
TTTATTGCTAGAGCTGTTGGAGATGGAATTTTATGTAATACCTATATTGATAGTTACAAAGGAACTGTAGATTGTGTGCAGGCTAGAGCT
GCTCTGGATAAGGCTACCGTGCTTCTGAGTATGTCTAAAGGTGGAAAGCGTAAAGATAGTGTGTGGGGCTCTGGAGGTGGGCAGCAATCT
GTCAATCACCTTGTTAAAGAGATTGATATGCTGCTGAAAGAATATTTACTCTCTGGAGACATATCTGAAGCTGAACATTGCCTTAAGGAA
CTGGAAGTACCTCATTTTCACCATGAGCTTGTATATGAAGCTATTATAATGGTTTTAGAGTCAACTGGAGAAAGTACATTTAAGATGATT
TTGGATTTATTAAAGTCCCTTTGGAAGTCTTCTACCATTACTGTAGACCAAATGAAAAGAGGTTATGAGAGAATTTACAATGAAATTCCG
GACATTAATCTGGATGTCCCACATTCATACTCTGTGCTGGAGCGGTTTGTAGAAGAATGTTTTCAGGCTGGAATAATTTCCAAACAACTC

>In-frame_PLEKHS1_ENST00000369312_chr10_115529659_+_PDCD4_ENST00000280154_chr10_112645011_+_1257nt
ATGCAATCTGTGCAGAAGATGTTTAAATGCCACCCTGATGAGGTCATGTCCATCAGAACCACTAACAGGGAATACTTCCTCATTGGCCAC
GACAGGGAGAAGATTAAAGACTGGGTCTCCTTCATGTCATCATTTCGCCAGGATATAAAAGCAACACAGCAGAACACAGAGGAGGAACTC
TCATTGGGTAATAAAAGAACCCTCTTCTACTCCAGCCCTCTCCTTGGCCCTTCCAGCACATCAGAGGCTGTTGGCTCCAGCTCACCAAGA
AATGGTCTCCAAGACAAGGAGAACTGTGTTTATGAAACTGTAGTTTTGCCTTTGGATGAAAGGGCATTTGAGAAGACTTTAACACCAATC
ATACAGGAATATTTTGAGCATGGAGATACTAATGAAGTTGCGGAAATGTTAAGAGATTTAAATCTTGGTGAAATGAAAAGTGGAGTACCA
GTGTTGGCAGTATCCTTAGCATTGGAGGGGAAGGCTAGTCATAGAGAGATGACATCTAAGCTTCTTTCTGACCTTTGTGGGACAGTAATG
AGCACAACTGATGTGGAAAAATCATTTGATAAATTGTTGAAAGATCTACCTGAATTAGCACTGGATACTCCTAGAGCACCACAGTTGGTG
GGCCAGTTTATTGCTAGAGCTGTTGGAGATGGAATTTTATGTAATACCTATATTGATAGTTACAAAGGAACTGTAGATTGTGTGCAGGCT
AGAGCTGCTCTGGATAAGGCTACCGTGCTTCTGAGTATGTCTAAAGGTGGAAAGCGTAAAGATAGTGTGTGGGGCTCTGGAGGTGGGCAG
CAATCTGTCAATCACCTTGTTAAAGAGATTGATATGCTGCTGAAAGAATATTTACTCTCTGGAGACATATCTGAAGCTGAACATTGCCTT
AAGGAACTGGAAGTACCTCATTTTCACCATGAGCTTGTATATGAAGCTATTATAATGGTTTTAGAGTCAACTGGAGAAAGTACATTTAAG
ATGATTTTGGATTTATTAAAGTCCCTTTGGAAGTCTTCTACCATTACTGTAGACCAAATGAAAAGAGGTTATGAGAGAATTTACAATGAA
ATTCCGGACATTAATCTGGATGTCCCACATTCATACTCTGTGCTGGAGCGGTTTGTAGAAGAATGTTTTCAGGCTGGAATAATTTCCAAA

>In-frame_PLEKHS1_ENST00000369312_chr10_115529659_+_PDCD4_ENST00000393104_chr10_112645011_+_1257nt
ATGCAATCTGTGCAGAAGATGTTTAAATGCCACCCTGATGAGGTCATGTCCATCAGAACCACTAACAGGGAATACTTCCTCATTGGCCAC
GACAGGGAGAAGATTAAAGACTGGGTCTCCTTCATGTCATCATTTCGCCAGGATATAAAAGCAACACAGCAGAACACAGAGGAGGAACTC
TCATTGGGTAATAAAAGAACCCTCTTCTACTCCAGCCCTCTCCTTGGCCCTTCCAGCACATCAGAGGCTGTTGGCTCCAGCTCACCAAGA
AATGGTCTCCAAGACAAGGAGAACTGTGTTTATGAAACTGTAGTTTTGCCTTTGGATGAAAGGGCATTTGAGAAGACTTTAACACCAATC
ATACAGGAATATTTTGAGCATGGAGATACTAATGAAGTTGCGGAAATGTTAAGAGATTTAAATCTTGGTGAAATGAAAAGTGGAGTACCA
GTGTTGGCAGTATCCTTAGCATTGGAGGGGAAGGCTAGTCATAGAGAGATGACATCTAAGCTTCTTTCTGACCTTTGTGGGACAGTAATG
AGCACAACTGATGTGGAAAAATCATTTGATAAATTGTTGAAAGATCTACCTGAATTAGCACTGGATACTCCTAGAGCACCACAGTTGGTG
GGCCAGTTTATTGCTAGAGCTGTTGGAGATGGAATTTTATGTAATACCTATATTGATAGTTACAAAGGAACTGTAGATTGTGTGCAGGCT
AGAGCTGCTCTGGATAAGGCTACCGTGCTTCTGAGTATGTCTAAAGGTGGAAAGCGTAAAGATAGTGTGTGGGGCTCTGGAGGTGGGCAG
CAATCTGTCAATCACCTTGTTAAAGAGATTGATATGCTGCTGAAAGAATATTTACTCTCTGGAGACATATCTGAAGCTGAACATTGCCTT
AAGGAACTGGAAGTACCTCATTTTCACCATGAGCTTGTATATGAAGCTATTATAATGGTTTTAGAGTCAACTGGAGAAAGTACATTTAAG
ATGATTTTGGATTTATTAAAGTCCCTTTGGAAGTCTTCTACCATTACTGTAGACCAAATGAAAAGAGGTTATGAGAGAATTTACAATGAA
ATTCCGGACATTAATCTGGATGTCCCACATTCATACTCTGTGCTGGAGCGGTTTGTAGAAGAATGTTTTCAGGCTGGAATAATTTCCAAA

>In-frame_PLEKHS1_ENST00000369310_chr10_115529659_+_PDCD4_ENST00000280154_chr10_112645011_+_1503nt
ATGGCTGGAGGCAAACAATTTACATTTTCTTATGAAAATGAAGTCTGCAAACAAGATTACTTTATTAAATCACCACCTTCTCAGCTGTTC
TCCTCTGTGACCTCTTGGAAAAAGCGGTTTTTCATCCTGTCAAAGGCTGGGGAAAAGAGCTTTAGTCTTTCCTATTATAAAGACCATCAT
CACCGAGGTTCCATTGAAATTGATCAAAATTCCAGTGTAGAAGTTGGCATAAGTAGCCAGGAAAAGATGCAATCTGTGCAGAAGATGTTT
AAATGCCACCCTGATGAGGTCATGTCCATCAGAACCACTAACAGGGAATACTTCCTCATTGGCCACGACAGGGAGAAGATTAAAGACTGG
GTCTCCTTCATGTCATCATTTCGCCAGGATATAAAAGCAACACAGCAGAACACAGAGGAGGAACTCTCATTGGGTAATAAAAGAACCCTC
TTCTACTCCAGCCCTCTCCTTGGCCCTTCCAGCACATCAGAGGCTGTTGGCTCCAGCTCACCAAGAAATGGTCTCCAAGACAAGGAGAAC
TGTGTTTATGAAACTGTAGTTTTGCCTTTGGATGAAAGGGCATTTGAGAAGACTTTAACACCAATCATACAGGAATATTTTGAGCATGGA
GATACTAATGAAGTTGCGGAAATGTTAAGAGATTTAAATCTTGGTGAAATGAAAAGTGGAGTACCAGTGTTGGCAGTATCCTTAGCATTG
GAGGGGAAGGCTAGTCATAGAGAGATGACATCTAAGCTTCTTTCTGACCTTTGTGGGACAGTAATGAGCACAACTGATGTGGAAAAATCA
TTTGATAAATTGTTGAAAGATCTACCTGAATTAGCACTGGATACTCCTAGAGCACCACAGTTGGTGGGCCAGTTTATTGCTAGAGCTGTT
GGAGATGGAATTTTATGTAATACCTATATTGATAGTTACAAAGGAACTGTAGATTGTGTGCAGGCTAGAGCTGCTCTGGATAAGGCTACC
GTGCTTCTGAGTATGTCTAAAGGTGGAAAGCGTAAAGATAGTGTGTGGGGCTCTGGAGGTGGGCAGCAATCTGTCAATCACCTTGTTAAA
GAGATTGATATGCTGCTGAAAGAATATTTACTCTCTGGAGACATATCTGAAGCTGAACATTGCCTTAAGGAACTGGAAGTACCTCATTTT
CACCATGAGCTTGTATATGAAGCTATTATAATGGTTTTAGAGTCAACTGGAGAAAGTACATTTAAGATGATTTTGGATTTATTAAAGTCC
CTTTGGAAGTCTTCTACCATTACTGTAGACCAAATGAAAAGAGGTTATGAGAGAATTTACAATGAAATTCCGGACATTAATCTGGATGTC
CCACATTCATACTCTGTGCTGGAGCGGTTTGTAGAAGAATGTTTTCAGGCTGGAATAATTTCCAAACAACTCAGAGATCTTTGTCCTTCA

>In-frame_PLEKHS1_ENST00000369310_chr10_115529659_+_PDCD4_ENST00000393104_chr10_112645011_+_1503nt
ATGGCTGGAGGCAAACAATTTACATTTTCTTATGAAAATGAAGTCTGCAAACAAGATTACTTTATTAAATCACCACCTTCTCAGCTGTTC
TCCTCTGTGACCTCTTGGAAAAAGCGGTTTTTCATCCTGTCAAAGGCTGGGGAAAAGAGCTTTAGTCTTTCCTATTATAAAGACCATCAT
CACCGAGGTTCCATTGAAATTGATCAAAATTCCAGTGTAGAAGTTGGCATAAGTAGCCAGGAAAAGATGCAATCTGTGCAGAAGATGTTT
AAATGCCACCCTGATGAGGTCATGTCCATCAGAACCACTAACAGGGAATACTTCCTCATTGGCCACGACAGGGAGAAGATTAAAGACTGG
GTCTCCTTCATGTCATCATTTCGCCAGGATATAAAAGCAACACAGCAGAACACAGAGGAGGAACTCTCATTGGGTAATAAAAGAACCCTC
TTCTACTCCAGCCCTCTCCTTGGCCCTTCCAGCACATCAGAGGCTGTTGGCTCCAGCTCACCAAGAAATGGTCTCCAAGACAAGGAGAAC
TGTGTTTATGAAACTGTAGTTTTGCCTTTGGATGAAAGGGCATTTGAGAAGACTTTAACACCAATCATACAGGAATATTTTGAGCATGGA
GATACTAATGAAGTTGCGGAAATGTTAAGAGATTTAAATCTTGGTGAAATGAAAAGTGGAGTACCAGTGTTGGCAGTATCCTTAGCATTG
GAGGGGAAGGCTAGTCATAGAGAGATGACATCTAAGCTTCTTTCTGACCTTTGTGGGACAGTAATGAGCACAACTGATGTGGAAAAATCA
TTTGATAAATTGTTGAAAGATCTACCTGAATTAGCACTGGATACTCCTAGAGCACCACAGTTGGTGGGCCAGTTTATTGCTAGAGCTGTT
GGAGATGGAATTTTATGTAATACCTATATTGATAGTTACAAAGGAACTGTAGATTGTGTGCAGGCTAGAGCTGCTCTGGATAAGGCTACC
GTGCTTCTGAGTATGTCTAAAGGTGGAAAGCGTAAAGATAGTGTGTGGGGCTCTGGAGGTGGGCAGCAATCTGTCAATCACCTTGTTAAA
GAGATTGATATGCTGCTGAAAGAATATTTACTCTCTGGAGACATATCTGAAGCTGAACATTGCCTTAAGGAACTGGAAGTACCTCATTTT
CACCATGAGCTTGTATATGAAGCTATTATAATGGTTTTAGAGTCAACTGGAGAAAGTACATTTAAGATGATTTTGGATTTATTAAAGTCC
CTTTGGAAGTCTTCTACCATTACTGTAGACCAAATGAAAAGAGGTTATGAGAGAATTTACAATGAAATTCCGGACATTAATCTGGATGTC
CCACATTCATACTCTGTGCTGGAGCGGTTTGTAGAAGAATGTTTTCAGGCTGGAATAATTTCCAAACAACTCAGAGATCTTTGTCCTTCA


* Fusion transcript sequences (Full-length transcript).
>In-frame_PLEKHS1_ENST00000361048_chr10_115529659_+_PDCD4_ENST00000280154_chr10_112645011_+_3766nt
ATTATTAATGTGTTTGCTTTCATTTTTGGTGCTAGGCAGCTGGGACACCAAGGAGAGTTCTGTGGCAAGCCACAAGTATGAAGGCCCAGA
ACTTCCCCTGAGGGCATAGCTTCCATTTCAGTTTGGGGCAAGAATAAAATCTGCTCAAGGATATTAGTTTGGGAACTTCCTGGTGGTTCA
GATTTCAAGCAGAGTTTGTGCTTAATCCTCACCCAGGCACCAAGGCTCAGAGTCAGCAGGAGTGAGTTCAGGAATCCTCGGGACAAGGCA
CTTTCCTGAGCACTGGACCAGCGACCTCTTGGCTTCCAGGGAGGACACACAGCCATCATGGAACCCAAACCTCAGAAGAGTCCAGGCAAA
CAATTTACATTTTCTTATGAAAATGAAGTCTGCAAACAAGATTACTTTATTAAATCACCACCTTCTCAGCTGTTCTCCTCTGTGACCTCT
TGGAAAAAGCGGTTTTTCATCCTGTCAAAGGCTGGGGAAAAGAGCTTTAGTCTTTCCTATTATAAAGACCATCATCACCGAGGTTCCATT
GAAATTGATCAAAATTCCAGTGTAGAAGTTGGCATAAGTAGCCAGGAAAAGATGCAATCTGTGCAGAAGATGTTTAAATGCCACCCTGAT
GAGGTCATGTCCATCAGAACCACTAACAGGGAATACTTCCTCATTGGCCACGACAGGGAGAAGATTAAAGACTGGGTCTCCTTCATGTCA
TCATTTCGCCAGGATATAAAAGCAACACAGCAGAACACAGAGGAGGAACTCTCATTGGGTAATAAAAGAACCCTCTTCTACTCCAGCCCT
CTCCTTGGCCCTTCCAGCACATCAGAGGCTGTTGGCTCCAGCTCACCAAGAAATGGTCTCCAAGACAAGGAGAACTGTGTTTATGAAACT
GTAGTTTTGCCTTTGGATGAAAGGGCATTTGAGAAGACTTTAACACCAATCATACAGGAATATTTTGAGCATGGAGATACTAATGAAGTT
GCGGAAATGTTAAGAGATTTAAATCTTGGTGAAATGAAAAGTGGAGTACCAGTGTTGGCAGTATCCTTAGCATTGGAGGGGAAGGCTAGT
CATAGAGAGATGACATCTAAGCTTCTTTCTGACCTTTGTGGGACAGTAATGAGCACAACTGATGTGGAAAAATCATTTGATAAATTGTTG
AAAGATCTACCTGAATTAGCACTGGATACTCCTAGAGCACCACAGTTGGTGGGCCAGTTTATTGCTAGAGCTGTTGGAGATGGAATTTTA
TGTAATACCTATATTGATAGTTACAAAGGAACTGTAGATTGTGTGCAGGCTAGAGCTGCTCTGGATAAGGCTACCGTGCTTCTGAGTATG
TCTAAAGGTGGAAAGCGTAAAGATAGTGTGTGGGGCTCTGGAGGTGGGCAGCAATCTGTCAATCACCTTGTTAAAGAGATTGATATGCTG
CTGAAAGAATATTTACTCTCTGGAGACATATCTGAAGCTGAACATTGCCTTAAGGAACTGGAAGTACCTCATTTTCACCATGAGCTTGTA
TATGAAGCTATTATAATGGTTTTAGAGTCAACTGGAGAAAGTACATTTAAGATGATTTTGGATTTATTAAAGTCCCTTTGGAAGTCTTCT
ACCATTACTGTAGACCAAATGAAAAGAGGTTATGAGAGAATTTACAATGAAATTCCGGACATTAATCTGGATGTCCCACATTCATACTCT
GTGCTGGAGCGGTTTGTAGAAGAATGTTTTCAGGCTGGAATAATTTCCAAACAACTCAGAGATCTTTGTCCTTCAAGGGGCAGAAAGCGT
TTTGTAAGCGAAGGAGATGGAGGTCGTCTTAAACCAGAGAGCTACTGAATATAAGAACTCTTGCAGTCTTAGATGTTATAAAAATATATA
TCTGAATTGTAAGAGTTGTTAGCACAAGTTTTTTTTTTTTTTTTTTTTAAGCACTTGTTTTGGGTACAAGGCATTTCTGACATTTTATAA
ACCTACATTTAAGGGGAATTTTTAAAGGAAATGTTTTTTCTTTTTTTTTTGTTTTTCGAGGGGGCAAGGAGGGACAGAAAAGTAACCTCT
TCTTAAGTGGAATATTCTAATAAGCTACCTTTTGTAAGTGCCATGTTTATTATCTAATCATTCCAAGTTTTGCATTGATGTCTGACTGCC
ACTCCTTTCTTTCAAGGACAGTGTTTTTTGTAGTAAAATCACTGGTTTATACAAAGCTTTATTTAGGGGGTAAAGTTAAGCTGCTAAAAC
CCCATGTTGGCTGCTGCTGTTGAGATACTGTGCTTTGGGAGTAAAAAAAGAAAGTTATTTCTTTGTCTTAAAGAATTTTTAAAAAATTAG
TCATGAGACTTATTCATCTTTCCAGGGAACATACTGATTGGTCTTAAAAGACTAGACAGTTAAGTAAAAGGTGGCTGGAACATCTATTTT
TCTACAAAACTGGAAAAATGAACCTGGTTCTAGAAGAATGTACACCAAAATAAAACATGTGAAGCAGTATTGATTCTTTATTGGGAGTAC
ATTTTTTTAGGTCTCTTAAACTTTAATTTCACACAGTAAATTTTGAATCTCATAAGGAAGCATATTTGAACCTAGTCAATTTAATCTTAG
TGTTCCCTTGAAAACTTTTTTTCCCTACAAAATTTTAAGTGAAAAATACAATAGTAAATTAAGATTACACTGGGGAAAAAAATGCAGGTA
TCACTTTACTCCATTGTTATCTGACCTAGAGCTTAATTAAGTTTTAGAAATATGTAATACCTTCCATCATTCCATCATCCTTAAATTCTG
TTACCAAATAATGGCTAATGTTACAAAAAGTTATACTCCAGAGACCCAAAGCTTGACATTTACCTAATGTATGAGAAAATATTACCAATT
AACAATAAAGAATGATCATATTTTTAACCTCTTTTACATAGCCTAATAACTCAGCAAGGCCTCAACGTCTGTGCTAATTTAAACTGCCAA
ATATTGACTGCAGCAAACAAGAATTATATTCAGAATTTATGAGGGTACTGTTAGGAGTATACTGCTTACAGGTTTAGATATAGTCTGTTA
GAATTAAAACCAAGTTTAGTGTTCATATTTACCTCATGGGCTTTATCAAGCCCATATTACCTCAGCTTATATATAGTTACCATTTTTAGG
TTTTTAATTGTTTGACACTTGGATGATAAATGCAGTCATTTTATTCTCAAGTGCTTAAAATTAATGTAATTAAAAGCTTAGCTGACTACA
GAATAGGTGAGGGTTTCTTAAAAATGAGATTTAAGGGCTGGGCACGGTGGCTCATGCCTGTAATCCCAGCACTTTGGGAGGCCGAGGTGG
GCGGATCACTTGAGGTTGGGAGTTCATGACCAGCTTGACCAACATGAAGAAACCCTGTCTCTATTAAAAATACAAAAGTAGCCAGGCATG
GTGGCGCATGCGTGTAATCCCAGCTACTTGGGAGGCTGAGGCAGGAGAATTGCTTGAACCTGGGAGGCAGAGGTTGCAGTGAGTCGAGAT
GGTGCCATTGCTCTCGTTTGGGCAACAAGAGTGAAACTCTTGTCTCAAAAAAAAAAAAAAATGAGGTTTAAGACAGTTTTGTCATTACTG
GTGGGATCTGGTCACACAAGATAGCATTAAACGTGACATGGCACATAAAATTGGTTAAAAAATTTTGTTTTTTAATTACGTAATGTAAAA

>In-frame_PLEKHS1_ENST00000361048_chr10_115529659_+_PDCD4_ENST00000393104_chr10_112645011_+_3765nt
ATTATTAATGTGTTTGCTTTCATTTTTGGTGCTAGGCAGCTGGGACACCAAGGAGAGTTCTGTGGCAAGCCACAAGTATGAAGGCCCAGA
ACTTCCCCTGAGGGCATAGCTTCCATTTCAGTTTGGGGCAAGAATAAAATCTGCTCAAGGATATTAGTTTGGGAACTTCCTGGTGGTTCA
GATTTCAAGCAGAGTTTGTGCTTAATCCTCACCCAGGCACCAAGGCTCAGAGTCAGCAGGAGTGAGTTCAGGAATCCTCGGGACAAGGCA
CTTTCCTGAGCACTGGACCAGCGACCTCTTGGCTTCCAGGGAGGACACACAGCCATCATGGAACCCAAACCTCAGAAGAGTCCAGGCAAA
CAATTTACATTTTCTTATGAAAATGAAGTCTGCAAACAAGATTACTTTATTAAATCACCACCTTCTCAGCTGTTCTCCTCTGTGACCTCT
TGGAAAAAGCGGTTTTTCATCCTGTCAAAGGCTGGGGAAAAGAGCTTTAGTCTTTCCTATTATAAAGACCATCATCACCGAGGTTCCATT
GAAATTGATCAAAATTCCAGTGTAGAAGTTGGCATAAGTAGCCAGGAAAAGATGCAATCTGTGCAGAAGATGTTTAAATGCCACCCTGAT
GAGGTCATGTCCATCAGAACCACTAACAGGGAATACTTCCTCATTGGCCACGACAGGGAGAAGATTAAAGACTGGGTCTCCTTCATGTCA
TCATTTCGCCAGGATATAAAAGCAACACAGCAGAACACAGAGGAGGAACTCTCATTGGGTAATAAAAGAACCCTCTTCTACTCCAGCCCT
CTCCTTGGCCCTTCCAGCACATCAGAGGCTGTTGGCTCCAGCTCACCAAGAAATGGTCTCCAAGACAAGGAGAACTGTGTTTATGAAACT
GTAGTTTTGCCTTTGGATGAAAGGGCATTTGAGAAGACTTTAACACCAATCATACAGGAATATTTTGAGCATGGAGATACTAATGAAGTT
GCGGAAATGTTAAGAGATTTAAATCTTGGTGAAATGAAAAGTGGAGTACCAGTGTTGGCAGTATCCTTAGCATTGGAGGGGAAGGCTAGT
CATAGAGAGATGACATCTAAGCTTCTTTCTGACCTTTGTGGGACAGTAATGAGCACAACTGATGTGGAAAAATCATTTGATAAATTGTTG
AAAGATCTACCTGAATTAGCACTGGATACTCCTAGAGCACCACAGTTGGTGGGCCAGTTTATTGCTAGAGCTGTTGGAGATGGAATTTTA
TGTAATACCTATATTGATAGTTACAAAGGAACTGTAGATTGTGTGCAGGCTAGAGCTGCTCTGGATAAGGCTACCGTGCTTCTGAGTATG
TCTAAAGGTGGAAAGCGTAAAGATAGTGTGTGGGGCTCTGGAGGTGGGCAGCAATCTGTCAATCACCTTGTTAAAGAGATTGATATGCTG
CTGAAAGAATATTTACTCTCTGGAGACATATCTGAAGCTGAACATTGCCTTAAGGAACTGGAAGTACCTCATTTTCACCATGAGCTTGTA
TATGAAGCTATTATAATGGTTTTAGAGTCAACTGGAGAAAGTACATTTAAGATGATTTTGGATTTATTAAAGTCCCTTTGGAAGTCTTCT
ACCATTACTGTAGACCAAATGAAAAGAGGTTATGAGAGAATTTACAATGAAATTCCGGACATTAATCTGGATGTCCCACATTCATACTCT
GTGCTGGAGCGGTTTGTAGAAGAATGTTTTCAGGCTGGAATAATTTCCAAACAACTCAGAGATCTTTGTCCTTCAAGGGGCAGAAAGCGT
TTTGTAAGCGAAGGAGATGGAGGTCGTCTTAAACCAGAGAGCTACTGAATATAAGAACTCTTGCAGTCTTAGATGTTATAAAAATATATA
TCTGAATTGTAAGAGTTGTTAGCACAAGTTTTTTTTTTTTTTTTTTTTAAGCACTTGTTTTGGGTACAAGGCATTTCTGACATTTTATAA
ACCTACATTTAAGGGGAATTTTTAAAGGAAATGTTTTTTCTTTTTTTTTTGTTTTTCGAGGGGGCAAGGAGGGACAGAAAAGTAACCTCT
TCTTAAGTGGAATATTCTAATAAGCTACCTTTTGTAAGTGCCATGTTTATTATCTAATCATTCCAAGTTTTGCATTGATGTCTGACTGCC
ACTCCTTTCTTTCAAGGACAGTGTTTTTTGTAGTAAAATCACTGGTTTATACAAAGCTTTATTTAGGGGGTAAAGTTAAGCTGCTAAAAC
CCCATGTTGGCTGCTGCTGTTGAGATACTGTGCTTTGGGAGTAAAAAAAGAAAGTTATTTCTTTGTCTTAAAGAATTTTTAAAAAATTAG
TCATGAGACTTATTCATCTTTCCAGGGAACATACTGATTGGTCTTAAAAGACTAGACAGTTAAGTAAAAGGTGGCTGGAACATCTATTTT
TCTACAAAACTGGAAAAATGAACCTGGTTCTAGAAGAATGTACACCAAAATAAAACATGTGAAGCAGTATTGATTCTTTATTGGGAGTAC
ATTTTTTTAGGTCTCTTAAACTTTAATTTCACACAGTAAATTTTGAATCTCATAAGGAAGCATATTTGAACCTAGTCAATTTAATCTTAG
TGTTCCCTTGAAAACTTTTTTTCCCTACAAAATTTTAAGTGAAAAATACAATAGTAAATTAAGATTACACTGGGGAAAAAAATGCAGGTA
TCACTTTACTCCATTGTTATCTGACCTAGAGCTTAATTAAGTTTTAGAAATATGTAATACCTTCCATCATTCCATCATCCTTAAATTCTG
TTACCAAATAATGGCTAATGTTACAAAAAGTTATACTCCAGAGACCCAAAGCTTGACATTTACCTAATGTATGAGAAAATATTACCAATT
AACAATAAAGAATGATCATATTTTTAACCTCTTTTACATAGCCTAATAACTCAGCAAGGCCTCAACGTCTGTGCTAATTTAAACTGCCAA
ATATTGACTGCAGCAAACAAGAATTATATTCAGAATTTATGAGGGTACTGTTAGGAGTATACTGCTTACAGGTTTAGATATAGTCTGTTA
GAATTAAAACCAAGTTTAGTGTTCATATTTACCTCATGGGCTTTATCAAGCCCATATTACCTCAGCTTATATATAGTTACCATTTTTAGG
TTTTTAATTGTTTGACACTTGGATGATAAATGCAGTCATTTTATTCTCAAGTGCTTAAAATTAATGTAATTAAAAGCTTAGCTGACTACA
GAATAGGTGAGGGTTTCTTAAAAATGAGATTTAAGGGCTGGGCACGGTGGCTCATGCCTGTAATCCCAGCACTTTGGGAGGCCGAGGTGG
GCGGATCACTTGAGGTTGGGAGTTCATGACCAGCTTGACCAACATGAAGAAACCCTGTCTCTATTAAAAATACAAAAGTAGCCAGGCATG
GTGGCGCATGCGTGTAATCCCAGCTACTTGGGAGGCTGAGGCAGGAGAATTGCTTGAACCTGGGAGGCAGAGGTTGCAGTGAGTCGAGAT
GGTGCCATTGCTCTCGTTTGGGCAACAAGAGTGAAACTCTTGTCTCAAAAAAAAAAAAAAATGAGGTTTAAGACAGTTTTGTCATTACTG
GTGGGATCTGGTCACACAAGATAGCATTAAACGTGACATGGCACATAAAATTGGTTAAAAAATTTTGTTTTTTAATTACGTAATGTAAAA

>In-frame_PLEKHS1_ENST00000369312_chr10_115529659_+_PDCD4_ENST00000280154_chr10_112645011_+_3638nt
AGAGTCAGCAGGAGTGAGTTCAGGAATCCTCGGGACAAGGCACTTTCCTGAGCACTGGACCAGCGACCTCTTGGCTTCCAGGGAGGACAC
ACAGCCATCATGGAACCCAAACCTCAGAAGAGTCCAGGTACCCGAGGGGTATAATCGCAGAAGCAGAAATCTTTTTATTGAAAATGCCCC
ACGGTTTCCTTCAAGCTAACCAGGATACAGAACTTGGTGGTTTTTGTGCAAACAATTTACATTTTCTTATGAAAATGAAGTCTGCAAACA
AGATTACTTTATTAAATCACCACCTTCTCAGCTGTTCTCCTCTGTGACCTCTTGGAAAAAGCGGTTTTTCATCCTGTCAAAGGCTGGGGA
AAAGAGCTTTAGTCTTTCCTATTATAAAGACCATCATCACCGAGGTTCCATTGAAATTGATCAAAATTCCAGTGTAGAAGTTGGCATAAG
TAGCCAGGAAAAGATGCAATCTGTGCAGAAGATGTTTAAATGCCACCCTGATGAGGTCATGTCCATCAGAACCACTAACAGGGAATACTT
CCTCATTGGCCACGACAGGGAGAAGATTAAAGACTGGGTCTCCTTCATGTCATCATTTCGCCAGGATATAAAAGCAACACAGCAGAACAC
AGAGGAGGAACTCTCATTGGGTAATAAAAGAACCCTCTTCTACTCCAGCCCTCTCCTTGGCCCTTCCAGCACATCAGAGGCTGTTGGCTC
CAGCTCACCAAGAAATGGTCTCCAAGACAAGGAGAACTGTGTTTATGAAACTGTAGTTTTGCCTTTGGATGAAAGGGCATTTGAGAAGAC
TTTAACACCAATCATACAGGAATATTTTGAGCATGGAGATACTAATGAAGTTGCGGAAATGTTAAGAGATTTAAATCTTGGTGAAATGAA
AAGTGGAGTACCAGTGTTGGCAGTATCCTTAGCATTGGAGGGGAAGGCTAGTCATAGAGAGATGACATCTAAGCTTCTTTCTGACCTTTG
TGGGACAGTAATGAGCACAACTGATGTGGAAAAATCATTTGATAAATTGTTGAAAGATCTACCTGAATTAGCACTGGATACTCCTAGAGC
ACCACAGTTGGTGGGCCAGTTTATTGCTAGAGCTGTTGGAGATGGAATTTTATGTAATACCTATATTGATAGTTACAAAGGAACTGTAGA
TTGTGTGCAGGCTAGAGCTGCTCTGGATAAGGCTACCGTGCTTCTGAGTATGTCTAAAGGTGGAAAGCGTAAAGATAGTGTGTGGGGCTC
TGGAGGTGGGCAGCAATCTGTCAATCACCTTGTTAAAGAGATTGATATGCTGCTGAAAGAATATTTACTCTCTGGAGACATATCTGAAGC
TGAACATTGCCTTAAGGAACTGGAAGTACCTCATTTTCACCATGAGCTTGTATATGAAGCTATTATAATGGTTTTAGAGTCAACTGGAGA
AAGTACATTTAAGATGATTTTGGATTTATTAAAGTCCCTTTGGAAGTCTTCTACCATTACTGTAGACCAAATGAAAAGAGGTTATGAGAG
AATTTACAATGAAATTCCGGACATTAATCTGGATGTCCCACATTCATACTCTGTGCTGGAGCGGTTTGTAGAAGAATGTTTTCAGGCTGG
AATAATTTCCAAACAACTCAGAGATCTTTGTCCTTCAAGGGGCAGAAAGCGTTTTGTAAGCGAAGGAGATGGAGGTCGTCTTAAACCAGA
GAGCTACTGAATATAAGAACTCTTGCAGTCTTAGATGTTATAAAAATATATATCTGAATTGTAAGAGTTGTTAGCACAAGTTTTTTTTTT
TTTTTTTTTTAAGCACTTGTTTTGGGTACAAGGCATTTCTGACATTTTATAAACCTACATTTAAGGGGAATTTTTAAAGGAAATGTTTTT
TCTTTTTTTTTTGTTTTTCGAGGGGGCAAGGAGGGACAGAAAAGTAACCTCTTCTTAAGTGGAATATTCTAATAAGCTACCTTTTGTAAG
TGCCATGTTTATTATCTAATCATTCCAAGTTTTGCATTGATGTCTGACTGCCACTCCTTTCTTTCAAGGACAGTGTTTTTTGTAGTAAAA
TCACTGGTTTATACAAAGCTTTATTTAGGGGGTAAAGTTAAGCTGCTAAAACCCCATGTTGGCTGCTGCTGTTGAGATACTGTGCTTTGG
GAGTAAAAAAAGAAAGTTATTTCTTTGTCTTAAAGAATTTTTAAAAAATTAGTCATGAGACTTATTCATCTTTCCAGGGAACATACTGAT
TGGTCTTAAAAGACTAGACAGTTAAGTAAAAGGTGGCTGGAACATCTATTTTTCTACAAAACTGGAAAAATGAACCTGGTTCTAGAAGAA
TGTACACCAAAATAAAACATGTGAAGCAGTATTGATTCTTTATTGGGAGTACATTTTTTTAGGTCTCTTAAACTTTAATTTCACACAGTA
AATTTTGAATCTCATAAGGAAGCATATTTGAACCTAGTCAATTTAATCTTAGTGTTCCCTTGAAAACTTTTTTTCCCTACAAAATTTTAA
GTGAAAAATACAATAGTAAATTAAGATTACACTGGGGAAAAAAATGCAGGTATCACTTTACTCCATTGTTATCTGACCTAGAGCTTAATT
AAGTTTTAGAAATATGTAATACCTTCCATCATTCCATCATCCTTAAATTCTGTTACCAAATAATGGCTAATGTTACAAAAAGTTATACTC
CAGAGACCCAAAGCTTGACATTTACCTAATGTATGAGAAAATATTACCAATTAACAATAAAGAATGATCATATTTTTAACCTCTTTTACA
TAGCCTAATAACTCAGCAAGGCCTCAACGTCTGTGCTAATTTAAACTGCCAAATATTGACTGCAGCAAACAAGAATTATATTCAGAATTT
ATGAGGGTACTGTTAGGAGTATACTGCTTACAGGTTTAGATATAGTCTGTTAGAATTAAAACCAAGTTTAGTGTTCATATTTACCTCATG
GGCTTTATCAAGCCCATATTACCTCAGCTTATATATAGTTACCATTTTTAGGTTTTTAATTGTTTGACACTTGGATGATAAATGCAGTCA
TTTTATTCTCAAGTGCTTAAAATTAATGTAATTAAAAGCTTAGCTGACTACAGAATAGGTGAGGGTTTCTTAAAAATGAGATTTAAGGGC
TGGGCACGGTGGCTCATGCCTGTAATCCCAGCACTTTGGGAGGCCGAGGTGGGCGGATCACTTGAGGTTGGGAGTTCATGACCAGCTTGA
CCAACATGAAGAAACCCTGTCTCTATTAAAAATACAAAAGTAGCCAGGCATGGTGGCGCATGCGTGTAATCCCAGCTACTTGGGAGGCTG
AGGCAGGAGAATTGCTTGAACCTGGGAGGCAGAGGTTGCAGTGAGTCGAGATGGTGCCATTGCTCTCGTTTGGGCAACAAGAGTGAAACT
CTTGTCTCAAAAAAAAAAAAAAATGAGGTTTAAGACAGTTTTGTCATTACTGGTGGGATCTGGTCACACAAGATAGCATTAAACGTGACA
TGGCACATAAAATTGGTTAAAAAATTTTGTTTTTTAATTACGTAATGTAAAAGCCCAACAAACACTTTATGCAAGATTGGAATGTATCTT

>In-frame_PLEKHS1_ENST00000369312_chr10_115529659_+_PDCD4_ENST00000393104_chr10_112645011_+_3637nt
AGAGTCAGCAGGAGTGAGTTCAGGAATCCTCGGGACAAGGCACTTTCCTGAGCACTGGACCAGCGACCTCTTGGCTTCCAGGGAGGACAC
ACAGCCATCATGGAACCCAAACCTCAGAAGAGTCCAGGTACCCGAGGGGTATAATCGCAGAAGCAGAAATCTTTTTATTGAAAATGCCCC
ACGGTTTCCTTCAAGCTAACCAGGATACAGAACTTGGTGGTTTTTGTGCAAACAATTTACATTTTCTTATGAAAATGAAGTCTGCAAACA
AGATTACTTTATTAAATCACCACCTTCTCAGCTGTTCTCCTCTGTGACCTCTTGGAAAAAGCGGTTTTTCATCCTGTCAAAGGCTGGGGA
AAAGAGCTTTAGTCTTTCCTATTATAAAGACCATCATCACCGAGGTTCCATTGAAATTGATCAAAATTCCAGTGTAGAAGTTGGCATAAG
TAGCCAGGAAAAGATGCAATCTGTGCAGAAGATGTTTAAATGCCACCCTGATGAGGTCATGTCCATCAGAACCACTAACAGGGAATACTT
CCTCATTGGCCACGACAGGGAGAAGATTAAAGACTGGGTCTCCTTCATGTCATCATTTCGCCAGGATATAAAAGCAACACAGCAGAACAC
AGAGGAGGAACTCTCATTGGGTAATAAAAGAACCCTCTTCTACTCCAGCCCTCTCCTTGGCCCTTCCAGCACATCAGAGGCTGTTGGCTC
CAGCTCACCAAGAAATGGTCTCCAAGACAAGGAGAACTGTGTTTATGAAACTGTAGTTTTGCCTTTGGATGAAAGGGCATTTGAGAAGAC
TTTAACACCAATCATACAGGAATATTTTGAGCATGGAGATACTAATGAAGTTGCGGAAATGTTAAGAGATTTAAATCTTGGTGAAATGAA
AAGTGGAGTACCAGTGTTGGCAGTATCCTTAGCATTGGAGGGGAAGGCTAGTCATAGAGAGATGACATCTAAGCTTCTTTCTGACCTTTG
TGGGACAGTAATGAGCACAACTGATGTGGAAAAATCATTTGATAAATTGTTGAAAGATCTACCTGAATTAGCACTGGATACTCCTAGAGC
ACCACAGTTGGTGGGCCAGTTTATTGCTAGAGCTGTTGGAGATGGAATTTTATGTAATACCTATATTGATAGTTACAAAGGAACTGTAGA
TTGTGTGCAGGCTAGAGCTGCTCTGGATAAGGCTACCGTGCTTCTGAGTATGTCTAAAGGTGGAAAGCGTAAAGATAGTGTGTGGGGCTC
TGGAGGTGGGCAGCAATCTGTCAATCACCTTGTTAAAGAGATTGATATGCTGCTGAAAGAATATTTACTCTCTGGAGACATATCTGAAGC
TGAACATTGCCTTAAGGAACTGGAAGTACCTCATTTTCACCATGAGCTTGTATATGAAGCTATTATAATGGTTTTAGAGTCAACTGGAGA
AAGTACATTTAAGATGATTTTGGATTTATTAAAGTCCCTTTGGAAGTCTTCTACCATTACTGTAGACCAAATGAAAAGAGGTTATGAGAG
AATTTACAATGAAATTCCGGACATTAATCTGGATGTCCCACATTCATACTCTGTGCTGGAGCGGTTTGTAGAAGAATGTTTTCAGGCTGG
AATAATTTCCAAACAACTCAGAGATCTTTGTCCTTCAAGGGGCAGAAAGCGTTTTGTAAGCGAAGGAGATGGAGGTCGTCTTAAACCAGA
GAGCTACTGAATATAAGAACTCTTGCAGTCTTAGATGTTATAAAAATATATATCTGAATTGTAAGAGTTGTTAGCACAAGTTTTTTTTTT
TTTTTTTTTTAAGCACTTGTTTTGGGTACAAGGCATTTCTGACATTTTATAAACCTACATTTAAGGGGAATTTTTAAAGGAAATGTTTTT
TCTTTTTTTTTTGTTTTTCGAGGGGGCAAGGAGGGACAGAAAAGTAACCTCTTCTTAAGTGGAATATTCTAATAAGCTACCTTTTGTAAG
TGCCATGTTTATTATCTAATCATTCCAAGTTTTGCATTGATGTCTGACTGCCACTCCTTTCTTTCAAGGACAGTGTTTTTTGTAGTAAAA
TCACTGGTTTATACAAAGCTTTATTTAGGGGGTAAAGTTAAGCTGCTAAAACCCCATGTTGGCTGCTGCTGTTGAGATACTGTGCTTTGG
GAGTAAAAAAAGAAAGTTATTTCTTTGTCTTAAAGAATTTTTAAAAAATTAGTCATGAGACTTATTCATCTTTCCAGGGAACATACTGAT
TGGTCTTAAAAGACTAGACAGTTAAGTAAAAGGTGGCTGGAACATCTATTTTTCTACAAAACTGGAAAAATGAACCTGGTTCTAGAAGAA
TGTACACCAAAATAAAACATGTGAAGCAGTATTGATTCTTTATTGGGAGTACATTTTTTTAGGTCTCTTAAACTTTAATTTCACACAGTA
AATTTTGAATCTCATAAGGAAGCATATTTGAACCTAGTCAATTTAATCTTAGTGTTCCCTTGAAAACTTTTTTTCCCTACAAAATTTTAA
GTGAAAAATACAATAGTAAATTAAGATTACACTGGGGAAAAAAATGCAGGTATCACTTTACTCCATTGTTATCTGACCTAGAGCTTAATT
AAGTTTTAGAAATATGTAATACCTTCCATCATTCCATCATCCTTAAATTCTGTTACCAAATAATGGCTAATGTTACAAAAAGTTATACTC
CAGAGACCCAAAGCTTGACATTTACCTAATGTATGAGAAAATATTACCAATTAACAATAAAGAATGATCATATTTTTAACCTCTTTTACA
TAGCCTAATAACTCAGCAAGGCCTCAACGTCTGTGCTAATTTAAACTGCCAAATATTGACTGCAGCAAACAAGAATTATATTCAGAATTT
ATGAGGGTACTGTTAGGAGTATACTGCTTACAGGTTTAGATATAGTCTGTTAGAATTAAAACCAAGTTTAGTGTTCATATTTACCTCATG
GGCTTTATCAAGCCCATATTACCTCAGCTTATATATAGTTACCATTTTTAGGTTTTTAATTGTTTGACACTTGGATGATAAATGCAGTCA
TTTTATTCTCAAGTGCTTAAAATTAATGTAATTAAAAGCTTAGCTGACTACAGAATAGGTGAGGGTTTCTTAAAAATGAGATTTAAGGGC
TGGGCACGGTGGCTCATGCCTGTAATCCCAGCACTTTGGGAGGCCGAGGTGGGCGGATCACTTGAGGTTGGGAGTTCATGACCAGCTTGA
CCAACATGAAGAAACCCTGTCTCTATTAAAAATACAAAAGTAGCCAGGCATGGTGGCGCATGCGTGTAATCCCAGCTACTTGGGAGGCTG
AGGCAGGAGAATTGCTTGAACCTGGGAGGCAGAGGTTGCAGTGAGTCGAGATGGTGCCATTGCTCTCGTTTGGGCAACAAGAGTGAAACT
CTTGTCTCAAAAAAAAAAAAAAATGAGGTTTAAGACAGTTTTGTCATTACTGGTGGGATCTGGTCACACAAGATAGCATTAAACGTGACA
TGGCACATAAAATTGGTTAAAAAATTTTGTTTTTTAATTACGTAATGTAAAAGCCCAACAAACACTTTATGCAAGATTGGAATGTATCTT

>In-frame_PLEKHS1_ENST00000369310_chr10_115529659_+_PDCD4_ENST00000280154_chr10_112645011_+_3983nt
ATGCCTTTAAGTGCACTAATCTTTTCTTGTACAATATTTAATCTGCTCTTACTCCCATCCAGTGTTGTTGCTGTTTTTTTGAGACATTGT
AGTTTTCATCTTTAAAATTTCACTTTAGGTCTTCTTTATATCTTTTATATCTCTCCCTAACTTTTTGAAAATATAGTGATAATAACTGCT
TTAATTACTTTCTCTGCCAATTCTAACATCTGTGTCAGTTCTAGGCCTGTTTTGATTGATTGACTTTCTTCTCATTATTGATCATGTTTT
CCTTCCTCTTTGTATGCCTGGTAAACTTTGATTGACTGCCAAACATCGCAAATTTTACCTTGTTGTTTCCTGAATATCTTTGTATTCCTA
TGAATCTTGAGCTTTGTTCTGGGATACAGTTAAATTTTTTGGGAACAACTTTCTTCTAAGTCTTTCATGATTTTTTAGGTGGGTTTGGAG
CAGTGCTCAGTGTAGAACTAGTAATTAGTGTAGAGCTAATTATTCCTCACACTGAGGCAAGACATTCCTGAGTACTCTACCCAATGCCCT
GTAAATTATAAGTTTTTCCAGTATGGCTGGAGGCAAACAATTTACATTTTCTTATGAAAATGAAGTCTGCAAACAAGATTACTTTATTAA
ATCACCACCTTCTCAGCTGTTCTCCTCTGTGACCTCTTGGAAAAAGCGGTTTTTCATCCTGTCAAAGGCTGGGGAAAAGAGCTTTAGTCT
TTCCTATTATAAAGACCATCATCACCGAGGTTCCATTGAAATTGATCAAAATTCCAGTGTAGAAGTTGGCATAAGTAGCCAGGAAAAGAT
GCAATCTGTGCAGAAGATGTTTAAATGCCACCCTGATGAGGTCATGTCCATCAGAACCACTAACAGGGAATACTTCCTCATTGGCCACGA
CAGGGAGAAGATTAAAGACTGGGTCTCCTTCATGTCATCATTTCGCCAGGATATAAAAGCAACACAGCAGAACACAGAGGAGGAACTCTC
ATTGGGTAATAAAAGAACCCTCTTCTACTCCAGCCCTCTCCTTGGCCCTTCCAGCACATCAGAGGCTGTTGGCTCCAGCTCACCAAGAAA
TGGTCTCCAAGACAAGGAGAACTGTGTTTATGAAACTGTAGTTTTGCCTTTGGATGAAAGGGCATTTGAGAAGACTTTAACACCAATCAT
ACAGGAATATTTTGAGCATGGAGATACTAATGAAGTTGCGGAAATGTTAAGAGATTTAAATCTTGGTGAAATGAAAAGTGGAGTACCAGT
GTTGGCAGTATCCTTAGCATTGGAGGGGAAGGCTAGTCATAGAGAGATGACATCTAAGCTTCTTTCTGACCTTTGTGGGACAGTAATGAG
CACAACTGATGTGGAAAAATCATTTGATAAATTGTTGAAAGATCTACCTGAATTAGCACTGGATACTCCTAGAGCACCACAGTTGGTGGG
CCAGTTTATTGCTAGAGCTGTTGGAGATGGAATTTTATGTAATACCTATATTGATAGTTACAAAGGAACTGTAGATTGTGTGCAGGCTAG
AGCTGCTCTGGATAAGGCTACCGTGCTTCTGAGTATGTCTAAAGGTGGAAAGCGTAAAGATAGTGTGTGGGGCTCTGGAGGTGGGCAGCA
ATCTGTCAATCACCTTGTTAAAGAGATTGATATGCTGCTGAAAGAATATTTACTCTCTGGAGACATATCTGAAGCTGAACATTGCCTTAA
GGAACTGGAAGTACCTCATTTTCACCATGAGCTTGTATATGAAGCTATTATAATGGTTTTAGAGTCAACTGGAGAAAGTACATTTAAGAT
GATTTTGGATTTATTAAAGTCCCTTTGGAAGTCTTCTACCATTACTGTAGACCAAATGAAAAGAGGTTATGAGAGAATTTACAATGAAAT
TCCGGACATTAATCTGGATGTCCCACATTCATACTCTGTGCTGGAGCGGTTTGTAGAAGAATGTTTTCAGGCTGGAATAATTTCCAAACA
ACTCAGAGATCTTTGTCCTTCAAGGGGCAGAAAGCGTTTTGTAAGCGAAGGAGATGGAGGTCGTCTTAAACCAGAGAGCTACTGAATATA
AGAACTCTTGCAGTCTTAGATGTTATAAAAATATATATCTGAATTGTAAGAGTTGTTAGCACAAGTTTTTTTTTTTTTTTTTTTTAAGCA
CTTGTTTTGGGTACAAGGCATTTCTGACATTTTATAAACCTACATTTAAGGGGAATTTTTAAAGGAAATGTTTTTTCTTTTTTTTTTGTT
TTTCGAGGGGGCAAGGAGGGACAGAAAAGTAACCTCTTCTTAAGTGGAATATTCTAATAAGCTACCTTTTGTAAGTGCCATGTTTATTAT
CTAATCATTCCAAGTTTTGCATTGATGTCTGACTGCCACTCCTTTCTTTCAAGGACAGTGTTTTTTGTAGTAAAATCACTGGTTTATACA
AAGCTTTATTTAGGGGGTAAAGTTAAGCTGCTAAAACCCCATGTTGGCTGCTGCTGTTGAGATACTGTGCTTTGGGAGTAAAAAAAGAAA
GTTATTTCTTTGTCTTAAAGAATTTTTAAAAAATTAGTCATGAGACTTATTCATCTTTCCAGGGAACATACTGATTGGTCTTAAAAGACT
AGACAGTTAAGTAAAAGGTGGCTGGAACATCTATTTTTCTACAAAACTGGAAAAATGAACCTGGTTCTAGAAGAATGTACACCAAAATAA
AACATGTGAAGCAGTATTGATTCTTTATTGGGAGTACATTTTTTTAGGTCTCTTAAACTTTAATTTCACACAGTAAATTTTGAATCTCAT
AAGGAAGCATATTTGAACCTAGTCAATTTAATCTTAGTGTTCCCTTGAAAACTTTTTTTCCCTACAAAATTTTAAGTGAAAAATACAATA
GTAAATTAAGATTACACTGGGGAAAAAAATGCAGGTATCACTTTACTCCATTGTTATCTGACCTAGAGCTTAATTAAGTTTTAGAAATAT
GTAATACCTTCCATCATTCCATCATCCTTAAATTCTGTTACCAAATAATGGCTAATGTTACAAAAAGTTATACTCCAGAGACCCAAAGCT
TGACATTTACCTAATGTATGAGAAAATATTACCAATTAACAATAAAGAATGATCATATTTTTAACCTCTTTTACATAGCCTAATAACTCA
GCAAGGCCTCAACGTCTGTGCTAATTTAAACTGCCAAATATTGACTGCAGCAAACAAGAATTATATTCAGAATTTATGAGGGTACTGTTA
GGAGTATACTGCTTACAGGTTTAGATATAGTCTGTTAGAATTAAAACCAAGTTTAGTGTTCATATTTACCTCATGGGCTTTATCAAGCCC
ATATTACCTCAGCTTATATATAGTTACCATTTTTAGGTTTTTAATTGTTTGACACTTGGATGATAAATGCAGTCATTTTATTCTCAAGTG
CTTAAAATTAATGTAATTAAAAGCTTAGCTGACTACAGAATAGGTGAGGGTTTCTTAAAAATGAGATTTAAGGGCTGGGCACGGTGGCTC
ATGCCTGTAATCCCAGCACTTTGGGAGGCCGAGGTGGGCGGATCACTTGAGGTTGGGAGTTCATGACCAGCTTGACCAACATGAAGAAAC
CCTGTCTCTATTAAAAATACAAAAGTAGCCAGGCATGGTGGCGCATGCGTGTAATCCCAGCTACTTGGGAGGCTGAGGCAGGAGAATTGC
TTGAACCTGGGAGGCAGAGGTTGCAGTGAGTCGAGATGGTGCCATTGCTCTCGTTTGGGCAACAAGAGTGAAACTCTTGTCTCAAAAAAA
AAAAAAAATGAGGTTTAAGACAGTTTTGTCATTACTGGTGGGATCTGGTCACACAAGATAGCATTAAACGTGACATGGCACATAAAATTG
GTTAAAAAATTTTGTTTTTTAATTACGTAATGTAAAAGCCCAACAAACACTTTATGCAAGATTGGAATGTATCTTCAAATTCAGATTTAA

>In-frame_PLEKHS1_ENST00000369310_chr10_115529659_+_PDCD4_ENST00000393104_chr10_112645011_+_3982nt
ATGCCTTTAAGTGCACTAATCTTTTCTTGTACAATATTTAATCTGCTCTTACTCCCATCCAGTGTTGTTGCTGTTTTTTTGAGACATTGT
AGTTTTCATCTTTAAAATTTCACTTTAGGTCTTCTTTATATCTTTTATATCTCTCCCTAACTTTTTGAAAATATAGTGATAATAACTGCT
TTAATTACTTTCTCTGCCAATTCTAACATCTGTGTCAGTTCTAGGCCTGTTTTGATTGATTGACTTTCTTCTCATTATTGATCATGTTTT
CCTTCCTCTTTGTATGCCTGGTAAACTTTGATTGACTGCCAAACATCGCAAATTTTACCTTGTTGTTTCCTGAATATCTTTGTATTCCTA
TGAATCTTGAGCTTTGTTCTGGGATACAGTTAAATTTTTTGGGAACAACTTTCTTCTAAGTCTTTCATGATTTTTTAGGTGGGTTTGGAG
CAGTGCTCAGTGTAGAACTAGTAATTAGTGTAGAGCTAATTATTCCTCACACTGAGGCAAGACATTCCTGAGTACTCTACCCAATGCCCT
GTAAATTATAAGTTTTTCCAGTATGGCTGGAGGCAAACAATTTACATTTTCTTATGAAAATGAAGTCTGCAAACAAGATTACTTTATTAA
ATCACCACCTTCTCAGCTGTTCTCCTCTGTGACCTCTTGGAAAAAGCGGTTTTTCATCCTGTCAAAGGCTGGGGAAAAGAGCTTTAGTCT
TTCCTATTATAAAGACCATCATCACCGAGGTTCCATTGAAATTGATCAAAATTCCAGTGTAGAAGTTGGCATAAGTAGCCAGGAAAAGAT
GCAATCTGTGCAGAAGATGTTTAAATGCCACCCTGATGAGGTCATGTCCATCAGAACCACTAACAGGGAATACTTCCTCATTGGCCACGA
CAGGGAGAAGATTAAAGACTGGGTCTCCTTCATGTCATCATTTCGCCAGGATATAAAAGCAACACAGCAGAACACAGAGGAGGAACTCTC
ATTGGGTAATAAAAGAACCCTCTTCTACTCCAGCCCTCTCCTTGGCCCTTCCAGCACATCAGAGGCTGTTGGCTCCAGCTCACCAAGAAA
TGGTCTCCAAGACAAGGAGAACTGTGTTTATGAAACTGTAGTTTTGCCTTTGGATGAAAGGGCATTTGAGAAGACTTTAACACCAATCAT
ACAGGAATATTTTGAGCATGGAGATACTAATGAAGTTGCGGAAATGTTAAGAGATTTAAATCTTGGTGAAATGAAAAGTGGAGTACCAGT
GTTGGCAGTATCCTTAGCATTGGAGGGGAAGGCTAGTCATAGAGAGATGACATCTAAGCTTCTTTCTGACCTTTGTGGGACAGTAATGAG
CACAACTGATGTGGAAAAATCATTTGATAAATTGTTGAAAGATCTACCTGAATTAGCACTGGATACTCCTAGAGCACCACAGTTGGTGGG
CCAGTTTATTGCTAGAGCTGTTGGAGATGGAATTTTATGTAATACCTATATTGATAGTTACAAAGGAACTGTAGATTGTGTGCAGGCTAG
AGCTGCTCTGGATAAGGCTACCGTGCTTCTGAGTATGTCTAAAGGTGGAAAGCGTAAAGATAGTGTGTGGGGCTCTGGAGGTGGGCAGCA
ATCTGTCAATCACCTTGTTAAAGAGATTGATATGCTGCTGAAAGAATATTTACTCTCTGGAGACATATCTGAAGCTGAACATTGCCTTAA
GGAACTGGAAGTACCTCATTTTCACCATGAGCTTGTATATGAAGCTATTATAATGGTTTTAGAGTCAACTGGAGAAAGTACATTTAAGAT
GATTTTGGATTTATTAAAGTCCCTTTGGAAGTCTTCTACCATTACTGTAGACCAAATGAAAAGAGGTTATGAGAGAATTTACAATGAAAT
TCCGGACATTAATCTGGATGTCCCACATTCATACTCTGTGCTGGAGCGGTTTGTAGAAGAATGTTTTCAGGCTGGAATAATTTCCAAACA
ACTCAGAGATCTTTGTCCTTCAAGGGGCAGAAAGCGTTTTGTAAGCGAAGGAGATGGAGGTCGTCTTAAACCAGAGAGCTACTGAATATA
AGAACTCTTGCAGTCTTAGATGTTATAAAAATATATATCTGAATTGTAAGAGTTGTTAGCACAAGTTTTTTTTTTTTTTTTTTTTAAGCA
CTTGTTTTGGGTACAAGGCATTTCTGACATTTTATAAACCTACATTTAAGGGGAATTTTTAAAGGAAATGTTTTTTCTTTTTTTTTTGTT
TTTCGAGGGGGCAAGGAGGGACAGAAAAGTAACCTCTTCTTAAGTGGAATATTCTAATAAGCTACCTTTTGTAAGTGCCATGTTTATTAT
CTAATCATTCCAAGTTTTGCATTGATGTCTGACTGCCACTCCTTTCTTTCAAGGACAGTGTTTTTTGTAGTAAAATCACTGGTTTATACA
AAGCTTTATTTAGGGGGTAAAGTTAAGCTGCTAAAACCCCATGTTGGCTGCTGCTGTTGAGATACTGTGCTTTGGGAGTAAAAAAAGAAA
GTTATTTCTTTGTCTTAAAGAATTTTTAAAAAATTAGTCATGAGACTTATTCATCTTTCCAGGGAACATACTGATTGGTCTTAAAAGACT
AGACAGTTAAGTAAAAGGTGGCTGGAACATCTATTTTTCTACAAAACTGGAAAAATGAACCTGGTTCTAGAAGAATGTACACCAAAATAA
AACATGTGAAGCAGTATTGATTCTTTATTGGGAGTACATTTTTTTAGGTCTCTTAAACTTTAATTTCACACAGTAAATTTTGAATCTCAT
AAGGAAGCATATTTGAACCTAGTCAATTTAATCTTAGTGTTCCCTTGAAAACTTTTTTTCCCTACAAAATTTTAAGTGAAAAATACAATA
GTAAATTAAGATTACACTGGGGAAAAAAATGCAGGTATCACTTTACTCCATTGTTATCTGACCTAGAGCTTAATTAAGTTTTAGAAATAT
GTAATACCTTCCATCATTCCATCATCCTTAAATTCTGTTACCAAATAATGGCTAATGTTACAAAAAGTTATACTCCAGAGACCCAAAGCT
TGACATTTACCTAATGTATGAGAAAATATTACCAATTAACAATAAAGAATGATCATATTTTTAACCTCTTTTACATAGCCTAATAACTCA
GCAAGGCCTCAACGTCTGTGCTAATTTAAACTGCCAAATATTGACTGCAGCAAACAAGAATTATATTCAGAATTTATGAGGGTACTGTTA
GGAGTATACTGCTTACAGGTTTAGATATAGTCTGTTAGAATTAAAACCAAGTTTAGTGTTCATATTTACCTCATGGGCTTTATCAAGCCC
ATATTACCTCAGCTTATATATAGTTACCATTTTTAGGTTTTTAATTGTTTGACACTTGGATGATAAATGCAGTCATTTTATTCTCAAGTG
CTTAAAATTAATGTAATTAAAAGCTTAGCTGACTACAGAATAGGTGAGGGTTTCTTAAAAATGAGATTTAAGGGCTGGGCACGGTGGCTC
ATGCCTGTAATCCCAGCACTTTGGGAGGCCGAGGTGGGCGGATCACTTGAGGTTGGGAGTTCATGACCAGCTTGACCAACATGAAGAAAC
CCTGTCTCTATTAAAAATACAAAAGTAGCCAGGCATGGTGGCGCATGCGTGTAATCCCAGCTACTTGGGAGGCTGAGGCAGGAGAATTGC
TTGAACCTGGGAGGCAGAGGTTGCAGTGAGTCGAGATGGTGCCATTGCTCTCGTTTGGGCAACAAGAGTGAAACTCTTGTCTCAAAAAAA
AAAAAAAATGAGGTTTAAGACAGTTTTGTCATTACTGGTGGGATCTGGTCACACAAGATAGCATTAAACGTGACATGGCACATAAAATTG
GTTAAAAAATTTTGTTTTTTAATTACGTAATGTAAAAGCCCAACAAACACTTTATGCAAGATTGGAATGTATCTTCAAATTCAGATTTAA


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FusionGenePPI for PLEKHS1_PDCD4


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors
PLEKHS1GRB2, PIK3R3, PBLDPDCD4EIF4A2, EIF4A1, RPL5, RPS13, EIF4G1, BTRC, FBXW11, EMD, ELAVL1, RPS6KA1, APOE, PSEN2, PSEN1, NAP1L1, NR1H2, VCP, CSNK2A1, DAXX, CD81, IGSF8, ARPC1B, BTF3, PAIP1, AAMP, TPD52, UFD1L, EIF4A3, TMEM51, COMTD1, RPS6KB2, HNRNPA1, UNK, EIF6, ETF1, NCAPD3, PCF11, EIF3H, EIF3I, PPP2R1B, PRMT5, PSMB6, THOC2, PSMC1, SNRPD1, NTRK1, UBE2S, HIST1H2BG, IBTK, CEP19, XPO1, TGIF2LY


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for PLEKHS1_PDCD4


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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RelatedDiseases for PLEKHS1_PDCD4


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
TgenePDCD4C0027626Neoplasm Invasiveness1CTD_human