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Fusion gene ID: 27676 |
FusionGeneSummary for PLEKHS1_PDCD4 |
 Fusion gene summary |
| Fusion gene information | Fusion gene name: PLEKHS1_PDCD4 | Fusion gene ID: 27676 | Hgene | Tgene | Gene symbol | PLEKHS1 | PDCD4 | Gene ID | 79949 | 27250 |
| Gene name | pleckstrin homology domain containing S1 | programmed cell death 4 | |
| Synonyms | C10orf81|HEL185|bA211N11.2 | H731 | |
| Cytomap | 10q25.3 | 10q25.2 | |
| Type of gene | protein-coding | protein-coding | |
| Description | pleckstrin homology domain-containing family S member 1PH domain-containing family S member 1PH domain-containing protein C10orf81epididymis luminal protein 185 | programmed cell death protein 4neoplastic transformation inhibitor proteinnuclear antigen H731programmed cell death 4 (neoplastic transformation inhibitor)protein 197/15a | |
| Modification date | 20180519 | 20180527 | |
| UniProtAcc | Q5SXH7 | Q53EL6 | |
| Ensembl transtripts involved in fusion gene | ENST00000361048, ENST00000369312, ENST00000369310, ENST00000369309, ENST00000354462, | ENST00000280154, ENST00000393104, ENST00000481353, | |
| Fusion gene scores | * DoF score | 2 X 1 X 2=4 | 3 X 3 X 2=18 |
| # samples | 2 | 3 | |
| ** MAII score | log2(2/4*10)=2.32192809488736 | log2(3/18*10)=0.736965594166206 effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs). DoF>8 and MAII>0 | |
| Context | PubMed: PLEKHS1 [Title/Abstract] AND PDCD4 [Title/Abstract] AND fusion [Title/Abstract] | ||
| Functional or gene categories assigned by FusionGDB annotation | Oncogene involved fusion gene, in-frame and retained their domain. Tumor suppressor gene involved fusion gene, in-frame but not retained their domain. Tumor suppressor gene involved fusion gene, retained protein feature but frameshift. DDR (DNA damage repair) gene involved fusion gene, in-frame but not retained their domain. | ||
| * DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
| Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Partner | Gene | GO ID | GO term | PubMed ID |
| Tgene | PDCD4 | GO:0007569 | cell aging | 12054647 |
| Tgene | PDCD4 | GO:0030509 | BMP signaling pathway | 18548003 |
| Tgene | PDCD4 | GO:0045892 | negative regulation of transcription, DNA-templated | 16357133 |
| Tgene | PDCD4 | GO:1905064 | negative regulation of vascular smooth muscle cell differentiation | 18548003 |
| Fusion gene information from three resources (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| TCGA | LD | BRCA | TCGA-BH-A42U-01A | PLEKHS1 | chr10 | 115529659 | + | PDCD4 | chr10 | 112645011 | + |
| * LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
| Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| In-frame | ENST00000361048 | ENST00000280154 | PLEKHS1 | chr10 | 115529659 | + | PDCD4 | chr10 | 112645011 | + |
| In-frame | ENST00000361048 | ENST00000393104 | PLEKHS1 | chr10 | 115529659 | + | PDCD4 | chr10 | 112645011 | + |
| 5CDS-3UTR | ENST00000361048 | ENST00000481353 | PLEKHS1 | chr10 | 115529659 | + | PDCD4 | chr10 | 112645011 | + |
| In-frame | ENST00000369312 | ENST00000280154 | PLEKHS1 | chr10 | 115529659 | + | PDCD4 | chr10 | 112645011 | + |
| In-frame | ENST00000369312 | ENST00000393104 | PLEKHS1 | chr10 | 115529659 | + | PDCD4 | chr10 | 112645011 | + |
| 5CDS-3UTR | ENST00000369312 | ENST00000481353 | PLEKHS1 | chr10 | 115529659 | + | PDCD4 | chr10 | 112645011 | + |
| In-frame | ENST00000369310 | ENST00000280154 | PLEKHS1 | chr10 | 115529659 | + | PDCD4 | chr10 | 112645011 | + |
| In-frame | ENST00000369310 | ENST00000393104 | PLEKHS1 | chr10 | 115529659 | + | PDCD4 | chr10 | 112645011 | + |
| 5CDS-3UTR | ENST00000369310 | ENST00000481353 | PLEKHS1 | chr10 | 115529659 | + | PDCD4 | chr10 | 112645011 | + |
| intron-3CDS | ENST00000369309 | ENST00000280154 | PLEKHS1 | chr10 | 115529659 | + | PDCD4 | chr10 | 112645011 | + |
| intron-3CDS | ENST00000369309 | ENST00000393104 | PLEKHS1 | chr10 | 115529659 | + | PDCD4 | chr10 | 112645011 | + |
| intron-3UTR | ENST00000369309 | ENST00000481353 | PLEKHS1 | chr10 | 115529659 | + | PDCD4 | chr10 | 112645011 | + |
| intron-3CDS | ENST00000354462 | ENST00000280154 | PLEKHS1 | chr10 | 115529659 | + | PDCD4 | chr10 | 112645011 | + |
| intron-3CDS | ENST00000354462 | ENST00000393104 | PLEKHS1 | chr10 | 115529659 | + | PDCD4 | chr10 | 112645011 | + |
| intron-3UTR | ENST00000354462 | ENST00000481353 | PLEKHS1 | chr10 | 115529659 | + | PDCD4 | chr10 | 112645011 | + |
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FusionProtFeatures for PLEKHS1_PDCD4 |
| Main function of each fusion partner protein. (from UniProt) |
| Hgene | Tgene |
| PLEKHS1 | PDCD4 |
| Inhibits translation initiation and cap-dependenttranslation. May excert its function by hindering the interactionbetween EIF4A1 and EIF4G. Inhibits the helicase activity of EIF4A.Modulates the activation of JUN kinase. Down-regulates theexpression of MAP4K1, thus inhibiting events important in drivinginvasion, namely, MAPK85 activation and consequent JUN-dependenttranscription. May play a role in apoptosis. Tumor suppressor.Inhibits tumor promoter-induced neoplastic transformation. BindsRNA (By similarity). {ECO:0000250, ECO:0000269|PubMed:16357133,ECO:0000269|PubMed:16449643, ECO:0000269|PubMed:17053147,ECO:0000269|PubMed:18296639, ECO:0000269|PubMed:19153607,ECO:0000269|PubMed:19204291}. |
| Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at . * Minus value of BPloci means that the break pointn is located before the CDS. |
| - In-frame and retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
| Hgene | PLEKHS1 | chr10:115529659 | chr10:112645011 | ENST00000361048 | + | 7 | 12 | 14_129 | 184 | 364 | Domain | PH |
| Hgene | PLEKHS1 | chr10:115529659 | chr10:112645011 | ENST00000369310 | + | 6 | 12 | 14_129 | 178 | 466 | Domain | PH |
| Tgene | >PDCD4 | chr10:115529659 | chr10:112645011 | ENST00000280154 | + | 3 | 12 | 163_284 | 147 | 470 | Domain | MI 1 |
| Tgene | >PDCD4 | chr10:115529659 | chr10:112645011 | ENST00000280154 | + | 3 | 12 | 326_449 | 147 | 470 | Domain | MI 2 |
| Tgene | >PDCD4 | chr10:115529659 | chr10:112645011 | ENST00000393104 | + | 4 | 13 | 163_284 | 136 | 459 | Domain | MI 1 |
| Tgene | >PDCD4 | chr10:115529659 | chr10:112645011 | ENST00000393104 | + | 4 | 13 | 326_449 | 136 | 459 | Domain | MI 2 |
| Tgene | >PDCD4 | chr10:115529659 | chr10:112645011 | ENST00000280154 | + | 3 | 12 | 241_250 | 147 | 470 | Motif | Nuclear localization signal |
| Tgene | >PDCD4 | chr10:115529659 | chr10:112645011 | ENST00000393104 | + | 4 | 13 | 241_250 | 136 | 459 | Motif | Nuclear localization signal |
| - In-frame and not-retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
| Hgene | >PLEKHS1 | chr10:115529659 | chr10:112645011 | ENST00000354462 | + | 1 | 6 | 14_129 | -53 | 199 | Domain | PH |
| Hgene | >PLEKHS1 | chr10:115529659 | chr10:112645011 | ENST00000369312 | + | 7 | 13 | 14_129 | 96 | 367 | Domain | PH |
| Tgene | PDCD4 | chr10:115529659 | chr10:112645011 | ENST00000280154 | + | 3 | 12 | 58_64 | 147 | 470 | Motif | Nuclear localization signal |
| Tgene | PDCD4 | chr10:115529659 | chr10:112645011 | ENST00000280154 | + | 3 | 12 | 70_76 | 147 | 470 | Motif | Note=Phosphodegron |
| Tgene | PDCD4 | chr10:115529659 | chr10:112645011 | ENST00000393104 | + | 4 | 13 | 58_64 | 136 | 459 | Motif | Nuclear localization signal |
| Tgene | PDCD4 | chr10:115529659 | chr10:112645011 | ENST00000393104 | + | 4 | 13 | 70_76 | 136 | 459 | Motif | Note=Phosphodegron |
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FusionGeneSequence for PLEKHS1_PDCD4 |
| For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. (nt: nucleotides, aa: amino acids) |
| * Fusion amino acid sequences. |
| >In-frame_PLEKHS1_ENST00000361048_chr10_115529659_+_PDCD4_ENST00000280154_chr10_112645011_+_507aa MEPKPQKSPGKQFTFSYENEVCKQDYFIKSPPSQLFSSVTSWKKRFFILSKAGEKSFSLSYYKDHHHRGSIEIDQNSSVEVGISSQEKMQ SVQKMFKCHPDEVMSIRTTNREYFLIGHDREKIKDWVSFMSSFRQDIKATQQNTEEELSLGNKRTLFYSSPLLGPSSTSEAVGSSSPRNG LQDKENCVYETVVLPLDERAFEKTLTPIIQEYFEHGDTNEVAEMLRDLNLGEMKSGVPVLAVSLALEGKASHREMTSKLLSDLCGTVMST TDVEKSFDKLLKDLPELALDTPRAPQLVGQFIARAVGDGILCNTYIDSYKGTVDCVQARAALDKATVLLSMSKGGKRKDSVWGSGGGQQS VNHLVKEIDMLLKEYLLSGDISEAEHCLKELEVPHFHHELVYEAIIMVLESTGESTFKMILDLLKSLWKSSTITVDQMKRGYERIYNEIP >In-frame_PLEKHS1_ENST00000361048_chr10_115529659_+_PDCD4_ENST00000393104_chr10_112645011_+_507aa MEPKPQKSPGKQFTFSYENEVCKQDYFIKSPPSQLFSSVTSWKKRFFILSKAGEKSFSLSYYKDHHHRGSIEIDQNSSVEVGISSQEKMQ SVQKMFKCHPDEVMSIRTTNREYFLIGHDREKIKDWVSFMSSFRQDIKATQQNTEEELSLGNKRTLFYSSPLLGPSSTSEAVGSSSPRNG LQDKENCVYETVVLPLDERAFEKTLTPIIQEYFEHGDTNEVAEMLRDLNLGEMKSGVPVLAVSLALEGKASHREMTSKLLSDLCGTVMST TDVEKSFDKLLKDLPELALDTPRAPQLVGQFIARAVGDGILCNTYIDSYKGTVDCVQARAALDKATVLLSMSKGGKRKDSVWGSGGGQQS VNHLVKEIDMLLKEYLLSGDISEAEHCLKELEVPHFHHELVYEAIIMVLESTGESTFKMILDLLKSLWKSSTITVDQMKRGYERIYNEIP >In-frame_PLEKHS1_ENST00000369312_chr10_115529659_+_PDCD4_ENST00000280154_chr10_112645011_+_419aa MQSVQKMFKCHPDEVMSIRTTNREYFLIGHDREKIKDWVSFMSSFRQDIKATQQNTEEELSLGNKRTLFYSSPLLGPSSTSEAVGSSSPR NGLQDKENCVYETVVLPLDERAFEKTLTPIIQEYFEHGDTNEVAEMLRDLNLGEMKSGVPVLAVSLALEGKASHREMTSKLLSDLCGTVM STTDVEKSFDKLLKDLPELALDTPRAPQLVGQFIARAVGDGILCNTYIDSYKGTVDCVQARAALDKATVLLSMSKGGKRKDSVWGSGGGQ QSVNHLVKEIDMLLKEYLLSGDISEAEHCLKELEVPHFHHELVYEAIIMVLESTGESTFKMILDLLKSLWKSSTITVDQMKRGYERIYNE >In-frame_PLEKHS1_ENST00000369312_chr10_115529659_+_PDCD4_ENST00000393104_chr10_112645011_+_419aa MQSVQKMFKCHPDEVMSIRTTNREYFLIGHDREKIKDWVSFMSSFRQDIKATQQNTEEELSLGNKRTLFYSSPLLGPSSTSEAVGSSSPR NGLQDKENCVYETVVLPLDERAFEKTLTPIIQEYFEHGDTNEVAEMLRDLNLGEMKSGVPVLAVSLALEGKASHREMTSKLLSDLCGTVM STTDVEKSFDKLLKDLPELALDTPRAPQLVGQFIARAVGDGILCNTYIDSYKGTVDCVQARAALDKATVLLSMSKGGKRKDSVWGSGGGQ QSVNHLVKEIDMLLKEYLLSGDISEAEHCLKELEVPHFHHELVYEAIIMVLESTGESTFKMILDLLKSLWKSSTITVDQMKRGYERIYNE >In-frame_PLEKHS1_ENST00000369310_chr10_115529659_+_PDCD4_ENST00000280154_chr10_112645011_+_501aa MAGGKQFTFSYENEVCKQDYFIKSPPSQLFSSVTSWKKRFFILSKAGEKSFSLSYYKDHHHRGSIEIDQNSSVEVGISSQEKMQSVQKMF KCHPDEVMSIRTTNREYFLIGHDREKIKDWVSFMSSFRQDIKATQQNTEEELSLGNKRTLFYSSPLLGPSSTSEAVGSSSPRNGLQDKEN CVYETVVLPLDERAFEKTLTPIIQEYFEHGDTNEVAEMLRDLNLGEMKSGVPVLAVSLALEGKASHREMTSKLLSDLCGTVMSTTDVEKS FDKLLKDLPELALDTPRAPQLVGQFIARAVGDGILCNTYIDSYKGTVDCVQARAALDKATVLLSMSKGGKRKDSVWGSGGGQQSVNHLVK EIDMLLKEYLLSGDISEAEHCLKELEVPHFHHELVYEAIIMVLESTGESTFKMILDLLKSLWKSSTITVDQMKRGYERIYNEIPDINLDV >In-frame_PLEKHS1_ENST00000369310_chr10_115529659_+_PDCD4_ENST00000393104_chr10_112645011_+_501aa MAGGKQFTFSYENEVCKQDYFIKSPPSQLFSSVTSWKKRFFILSKAGEKSFSLSYYKDHHHRGSIEIDQNSSVEVGISSQEKMQSVQKMF KCHPDEVMSIRTTNREYFLIGHDREKIKDWVSFMSSFRQDIKATQQNTEEELSLGNKRTLFYSSPLLGPSSTSEAVGSSSPRNGLQDKEN CVYETVVLPLDERAFEKTLTPIIQEYFEHGDTNEVAEMLRDLNLGEMKSGVPVLAVSLALEGKASHREMTSKLLSDLCGTVMSTTDVEKS FDKLLKDLPELALDTPRAPQLVGQFIARAVGDGILCNTYIDSYKGTVDCVQARAALDKATVLLSMSKGGKRKDSVWGSGGGQQSVNHLVK EIDMLLKEYLLSGDISEAEHCLKELEVPHFHHELVYEAIIMVLESTGESTFKMILDLLKSLWKSSTITVDQMKRGYERIYNEIPDINLDV |
| * Fusion transcript sequences (only coding sequence (CDS) region). |
| >In-frame_PLEKHS1_ENST00000361048_chr10_115529659_+_PDCD4_ENST00000280154_chr10_112645011_+_1521nt ATGGAACCCAAACCTCAGAAGAGTCCAGGCAAACAATTTACATTTTCTTATGAAAATGAAGTCTGCAAACAAGATTACTTTATTAAATCA CCACCTTCTCAGCTGTTCTCCTCTGTGACCTCTTGGAAAAAGCGGTTTTTCATCCTGTCAAAGGCTGGGGAAAAGAGCTTTAGTCTTTCC TATTATAAAGACCATCATCACCGAGGTTCCATTGAAATTGATCAAAATTCCAGTGTAGAAGTTGGCATAAGTAGCCAGGAAAAGATGCAA TCTGTGCAGAAGATGTTTAAATGCCACCCTGATGAGGTCATGTCCATCAGAACCACTAACAGGGAATACTTCCTCATTGGCCACGACAGG GAGAAGATTAAAGACTGGGTCTCCTTCATGTCATCATTTCGCCAGGATATAAAAGCAACACAGCAGAACACAGAGGAGGAACTCTCATTG GGTAATAAAAGAACCCTCTTCTACTCCAGCCCTCTCCTTGGCCCTTCCAGCACATCAGAGGCTGTTGGCTCCAGCTCACCAAGAAATGGT CTCCAAGACAAGGAGAACTGTGTTTATGAAACTGTAGTTTTGCCTTTGGATGAAAGGGCATTTGAGAAGACTTTAACACCAATCATACAG GAATATTTTGAGCATGGAGATACTAATGAAGTTGCGGAAATGTTAAGAGATTTAAATCTTGGTGAAATGAAAAGTGGAGTACCAGTGTTG GCAGTATCCTTAGCATTGGAGGGGAAGGCTAGTCATAGAGAGATGACATCTAAGCTTCTTTCTGACCTTTGTGGGACAGTAATGAGCACA ACTGATGTGGAAAAATCATTTGATAAATTGTTGAAAGATCTACCTGAATTAGCACTGGATACTCCTAGAGCACCACAGTTGGTGGGCCAG TTTATTGCTAGAGCTGTTGGAGATGGAATTTTATGTAATACCTATATTGATAGTTACAAAGGAACTGTAGATTGTGTGCAGGCTAGAGCT GCTCTGGATAAGGCTACCGTGCTTCTGAGTATGTCTAAAGGTGGAAAGCGTAAAGATAGTGTGTGGGGCTCTGGAGGTGGGCAGCAATCT GTCAATCACCTTGTTAAAGAGATTGATATGCTGCTGAAAGAATATTTACTCTCTGGAGACATATCTGAAGCTGAACATTGCCTTAAGGAA CTGGAAGTACCTCATTTTCACCATGAGCTTGTATATGAAGCTATTATAATGGTTTTAGAGTCAACTGGAGAAAGTACATTTAAGATGATT TTGGATTTATTAAAGTCCCTTTGGAAGTCTTCTACCATTACTGTAGACCAAATGAAAAGAGGTTATGAGAGAATTTACAATGAAATTCCG GACATTAATCTGGATGTCCCACATTCATACTCTGTGCTGGAGCGGTTTGTAGAAGAATGTTTTCAGGCTGGAATAATTTCCAAACAACTC >In-frame_PLEKHS1_ENST00000361048_chr10_115529659_+_PDCD4_ENST00000393104_chr10_112645011_+_1521nt ATGGAACCCAAACCTCAGAAGAGTCCAGGCAAACAATTTACATTTTCTTATGAAAATGAAGTCTGCAAACAAGATTACTTTATTAAATCA CCACCTTCTCAGCTGTTCTCCTCTGTGACCTCTTGGAAAAAGCGGTTTTTCATCCTGTCAAAGGCTGGGGAAAAGAGCTTTAGTCTTTCC TATTATAAAGACCATCATCACCGAGGTTCCATTGAAATTGATCAAAATTCCAGTGTAGAAGTTGGCATAAGTAGCCAGGAAAAGATGCAA TCTGTGCAGAAGATGTTTAAATGCCACCCTGATGAGGTCATGTCCATCAGAACCACTAACAGGGAATACTTCCTCATTGGCCACGACAGG GAGAAGATTAAAGACTGGGTCTCCTTCATGTCATCATTTCGCCAGGATATAAAAGCAACACAGCAGAACACAGAGGAGGAACTCTCATTG GGTAATAAAAGAACCCTCTTCTACTCCAGCCCTCTCCTTGGCCCTTCCAGCACATCAGAGGCTGTTGGCTCCAGCTCACCAAGAAATGGT CTCCAAGACAAGGAGAACTGTGTTTATGAAACTGTAGTTTTGCCTTTGGATGAAAGGGCATTTGAGAAGACTTTAACACCAATCATACAG GAATATTTTGAGCATGGAGATACTAATGAAGTTGCGGAAATGTTAAGAGATTTAAATCTTGGTGAAATGAAAAGTGGAGTACCAGTGTTG GCAGTATCCTTAGCATTGGAGGGGAAGGCTAGTCATAGAGAGATGACATCTAAGCTTCTTTCTGACCTTTGTGGGACAGTAATGAGCACA ACTGATGTGGAAAAATCATTTGATAAATTGTTGAAAGATCTACCTGAATTAGCACTGGATACTCCTAGAGCACCACAGTTGGTGGGCCAG TTTATTGCTAGAGCTGTTGGAGATGGAATTTTATGTAATACCTATATTGATAGTTACAAAGGAACTGTAGATTGTGTGCAGGCTAGAGCT GCTCTGGATAAGGCTACCGTGCTTCTGAGTATGTCTAAAGGTGGAAAGCGTAAAGATAGTGTGTGGGGCTCTGGAGGTGGGCAGCAATCT GTCAATCACCTTGTTAAAGAGATTGATATGCTGCTGAAAGAATATTTACTCTCTGGAGACATATCTGAAGCTGAACATTGCCTTAAGGAA CTGGAAGTACCTCATTTTCACCATGAGCTTGTATATGAAGCTATTATAATGGTTTTAGAGTCAACTGGAGAAAGTACATTTAAGATGATT TTGGATTTATTAAAGTCCCTTTGGAAGTCTTCTACCATTACTGTAGACCAAATGAAAAGAGGTTATGAGAGAATTTACAATGAAATTCCG GACATTAATCTGGATGTCCCACATTCATACTCTGTGCTGGAGCGGTTTGTAGAAGAATGTTTTCAGGCTGGAATAATTTCCAAACAACTC >In-frame_PLEKHS1_ENST00000369312_chr10_115529659_+_PDCD4_ENST00000280154_chr10_112645011_+_1257nt ATGCAATCTGTGCAGAAGATGTTTAAATGCCACCCTGATGAGGTCATGTCCATCAGAACCACTAACAGGGAATACTTCCTCATTGGCCAC GACAGGGAGAAGATTAAAGACTGGGTCTCCTTCATGTCATCATTTCGCCAGGATATAAAAGCAACACAGCAGAACACAGAGGAGGAACTC TCATTGGGTAATAAAAGAACCCTCTTCTACTCCAGCCCTCTCCTTGGCCCTTCCAGCACATCAGAGGCTGTTGGCTCCAGCTCACCAAGA AATGGTCTCCAAGACAAGGAGAACTGTGTTTATGAAACTGTAGTTTTGCCTTTGGATGAAAGGGCATTTGAGAAGACTTTAACACCAATC ATACAGGAATATTTTGAGCATGGAGATACTAATGAAGTTGCGGAAATGTTAAGAGATTTAAATCTTGGTGAAATGAAAAGTGGAGTACCA GTGTTGGCAGTATCCTTAGCATTGGAGGGGAAGGCTAGTCATAGAGAGATGACATCTAAGCTTCTTTCTGACCTTTGTGGGACAGTAATG AGCACAACTGATGTGGAAAAATCATTTGATAAATTGTTGAAAGATCTACCTGAATTAGCACTGGATACTCCTAGAGCACCACAGTTGGTG GGCCAGTTTATTGCTAGAGCTGTTGGAGATGGAATTTTATGTAATACCTATATTGATAGTTACAAAGGAACTGTAGATTGTGTGCAGGCT AGAGCTGCTCTGGATAAGGCTACCGTGCTTCTGAGTATGTCTAAAGGTGGAAAGCGTAAAGATAGTGTGTGGGGCTCTGGAGGTGGGCAG CAATCTGTCAATCACCTTGTTAAAGAGATTGATATGCTGCTGAAAGAATATTTACTCTCTGGAGACATATCTGAAGCTGAACATTGCCTT AAGGAACTGGAAGTACCTCATTTTCACCATGAGCTTGTATATGAAGCTATTATAATGGTTTTAGAGTCAACTGGAGAAAGTACATTTAAG ATGATTTTGGATTTATTAAAGTCCCTTTGGAAGTCTTCTACCATTACTGTAGACCAAATGAAAAGAGGTTATGAGAGAATTTACAATGAA ATTCCGGACATTAATCTGGATGTCCCACATTCATACTCTGTGCTGGAGCGGTTTGTAGAAGAATGTTTTCAGGCTGGAATAATTTCCAAA >In-frame_PLEKHS1_ENST00000369312_chr10_115529659_+_PDCD4_ENST00000393104_chr10_112645011_+_1257nt ATGCAATCTGTGCAGAAGATGTTTAAATGCCACCCTGATGAGGTCATGTCCATCAGAACCACTAACAGGGAATACTTCCTCATTGGCCAC GACAGGGAGAAGATTAAAGACTGGGTCTCCTTCATGTCATCATTTCGCCAGGATATAAAAGCAACACAGCAGAACACAGAGGAGGAACTC TCATTGGGTAATAAAAGAACCCTCTTCTACTCCAGCCCTCTCCTTGGCCCTTCCAGCACATCAGAGGCTGTTGGCTCCAGCTCACCAAGA AATGGTCTCCAAGACAAGGAGAACTGTGTTTATGAAACTGTAGTTTTGCCTTTGGATGAAAGGGCATTTGAGAAGACTTTAACACCAATC ATACAGGAATATTTTGAGCATGGAGATACTAATGAAGTTGCGGAAATGTTAAGAGATTTAAATCTTGGTGAAATGAAAAGTGGAGTACCA GTGTTGGCAGTATCCTTAGCATTGGAGGGGAAGGCTAGTCATAGAGAGATGACATCTAAGCTTCTTTCTGACCTTTGTGGGACAGTAATG AGCACAACTGATGTGGAAAAATCATTTGATAAATTGTTGAAAGATCTACCTGAATTAGCACTGGATACTCCTAGAGCACCACAGTTGGTG GGCCAGTTTATTGCTAGAGCTGTTGGAGATGGAATTTTATGTAATACCTATATTGATAGTTACAAAGGAACTGTAGATTGTGTGCAGGCT AGAGCTGCTCTGGATAAGGCTACCGTGCTTCTGAGTATGTCTAAAGGTGGAAAGCGTAAAGATAGTGTGTGGGGCTCTGGAGGTGGGCAG CAATCTGTCAATCACCTTGTTAAAGAGATTGATATGCTGCTGAAAGAATATTTACTCTCTGGAGACATATCTGAAGCTGAACATTGCCTT AAGGAACTGGAAGTACCTCATTTTCACCATGAGCTTGTATATGAAGCTATTATAATGGTTTTAGAGTCAACTGGAGAAAGTACATTTAAG ATGATTTTGGATTTATTAAAGTCCCTTTGGAAGTCTTCTACCATTACTGTAGACCAAATGAAAAGAGGTTATGAGAGAATTTACAATGAA ATTCCGGACATTAATCTGGATGTCCCACATTCATACTCTGTGCTGGAGCGGTTTGTAGAAGAATGTTTTCAGGCTGGAATAATTTCCAAA >In-frame_PLEKHS1_ENST00000369310_chr10_115529659_+_PDCD4_ENST00000280154_chr10_112645011_+_1503nt ATGGCTGGAGGCAAACAATTTACATTTTCTTATGAAAATGAAGTCTGCAAACAAGATTACTTTATTAAATCACCACCTTCTCAGCTGTTC TCCTCTGTGACCTCTTGGAAAAAGCGGTTTTTCATCCTGTCAAAGGCTGGGGAAAAGAGCTTTAGTCTTTCCTATTATAAAGACCATCAT CACCGAGGTTCCATTGAAATTGATCAAAATTCCAGTGTAGAAGTTGGCATAAGTAGCCAGGAAAAGATGCAATCTGTGCAGAAGATGTTT AAATGCCACCCTGATGAGGTCATGTCCATCAGAACCACTAACAGGGAATACTTCCTCATTGGCCACGACAGGGAGAAGATTAAAGACTGG GTCTCCTTCATGTCATCATTTCGCCAGGATATAAAAGCAACACAGCAGAACACAGAGGAGGAACTCTCATTGGGTAATAAAAGAACCCTC TTCTACTCCAGCCCTCTCCTTGGCCCTTCCAGCACATCAGAGGCTGTTGGCTCCAGCTCACCAAGAAATGGTCTCCAAGACAAGGAGAAC TGTGTTTATGAAACTGTAGTTTTGCCTTTGGATGAAAGGGCATTTGAGAAGACTTTAACACCAATCATACAGGAATATTTTGAGCATGGA GATACTAATGAAGTTGCGGAAATGTTAAGAGATTTAAATCTTGGTGAAATGAAAAGTGGAGTACCAGTGTTGGCAGTATCCTTAGCATTG GAGGGGAAGGCTAGTCATAGAGAGATGACATCTAAGCTTCTTTCTGACCTTTGTGGGACAGTAATGAGCACAACTGATGTGGAAAAATCA TTTGATAAATTGTTGAAAGATCTACCTGAATTAGCACTGGATACTCCTAGAGCACCACAGTTGGTGGGCCAGTTTATTGCTAGAGCTGTT GGAGATGGAATTTTATGTAATACCTATATTGATAGTTACAAAGGAACTGTAGATTGTGTGCAGGCTAGAGCTGCTCTGGATAAGGCTACC GTGCTTCTGAGTATGTCTAAAGGTGGAAAGCGTAAAGATAGTGTGTGGGGCTCTGGAGGTGGGCAGCAATCTGTCAATCACCTTGTTAAA GAGATTGATATGCTGCTGAAAGAATATTTACTCTCTGGAGACATATCTGAAGCTGAACATTGCCTTAAGGAACTGGAAGTACCTCATTTT CACCATGAGCTTGTATATGAAGCTATTATAATGGTTTTAGAGTCAACTGGAGAAAGTACATTTAAGATGATTTTGGATTTATTAAAGTCC CTTTGGAAGTCTTCTACCATTACTGTAGACCAAATGAAAAGAGGTTATGAGAGAATTTACAATGAAATTCCGGACATTAATCTGGATGTC CCACATTCATACTCTGTGCTGGAGCGGTTTGTAGAAGAATGTTTTCAGGCTGGAATAATTTCCAAACAACTCAGAGATCTTTGTCCTTCA >In-frame_PLEKHS1_ENST00000369310_chr10_115529659_+_PDCD4_ENST00000393104_chr10_112645011_+_1503nt ATGGCTGGAGGCAAACAATTTACATTTTCTTATGAAAATGAAGTCTGCAAACAAGATTACTTTATTAAATCACCACCTTCTCAGCTGTTC TCCTCTGTGACCTCTTGGAAAAAGCGGTTTTTCATCCTGTCAAAGGCTGGGGAAAAGAGCTTTAGTCTTTCCTATTATAAAGACCATCAT CACCGAGGTTCCATTGAAATTGATCAAAATTCCAGTGTAGAAGTTGGCATAAGTAGCCAGGAAAAGATGCAATCTGTGCAGAAGATGTTT AAATGCCACCCTGATGAGGTCATGTCCATCAGAACCACTAACAGGGAATACTTCCTCATTGGCCACGACAGGGAGAAGATTAAAGACTGG GTCTCCTTCATGTCATCATTTCGCCAGGATATAAAAGCAACACAGCAGAACACAGAGGAGGAACTCTCATTGGGTAATAAAAGAACCCTC TTCTACTCCAGCCCTCTCCTTGGCCCTTCCAGCACATCAGAGGCTGTTGGCTCCAGCTCACCAAGAAATGGTCTCCAAGACAAGGAGAAC TGTGTTTATGAAACTGTAGTTTTGCCTTTGGATGAAAGGGCATTTGAGAAGACTTTAACACCAATCATACAGGAATATTTTGAGCATGGA GATACTAATGAAGTTGCGGAAATGTTAAGAGATTTAAATCTTGGTGAAATGAAAAGTGGAGTACCAGTGTTGGCAGTATCCTTAGCATTG GAGGGGAAGGCTAGTCATAGAGAGATGACATCTAAGCTTCTTTCTGACCTTTGTGGGACAGTAATGAGCACAACTGATGTGGAAAAATCA TTTGATAAATTGTTGAAAGATCTACCTGAATTAGCACTGGATACTCCTAGAGCACCACAGTTGGTGGGCCAGTTTATTGCTAGAGCTGTT GGAGATGGAATTTTATGTAATACCTATATTGATAGTTACAAAGGAACTGTAGATTGTGTGCAGGCTAGAGCTGCTCTGGATAAGGCTACC GTGCTTCTGAGTATGTCTAAAGGTGGAAAGCGTAAAGATAGTGTGTGGGGCTCTGGAGGTGGGCAGCAATCTGTCAATCACCTTGTTAAA GAGATTGATATGCTGCTGAAAGAATATTTACTCTCTGGAGACATATCTGAAGCTGAACATTGCCTTAAGGAACTGGAAGTACCTCATTTT CACCATGAGCTTGTATATGAAGCTATTATAATGGTTTTAGAGTCAACTGGAGAAAGTACATTTAAGATGATTTTGGATTTATTAAAGTCC CTTTGGAAGTCTTCTACCATTACTGTAGACCAAATGAAAAGAGGTTATGAGAGAATTTACAATGAAATTCCGGACATTAATCTGGATGTC CCACATTCATACTCTGTGCTGGAGCGGTTTGTAGAAGAATGTTTTCAGGCTGGAATAATTTCCAAACAACTCAGAGATCTTTGTCCTTCA |
| * Fusion transcript sequences (Full-length transcript). |
| >In-frame_PLEKHS1_ENST00000361048_chr10_115529659_+_PDCD4_ENST00000280154_chr10_112645011_+_3766nt ATTATTAATGTGTTTGCTTTCATTTTTGGTGCTAGGCAGCTGGGACACCAAGGAGAGTTCTGTGGCAAGCCACAAGTATGAAGGCCCAGA ACTTCCCCTGAGGGCATAGCTTCCATTTCAGTTTGGGGCAAGAATAAAATCTGCTCAAGGATATTAGTTTGGGAACTTCCTGGTGGTTCA GATTTCAAGCAGAGTTTGTGCTTAATCCTCACCCAGGCACCAAGGCTCAGAGTCAGCAGGAGTGAGTTCAGGAATCCTCGGGACAAGGCA CTTTCCTGAGCACTGGACCAGCGACCTCTTGGCTTCCAGGGAGGACACACAGCCATCATGGAACCCAAACCTCAGAAGAGTCCAGGCAAA CAATTTACATTTTCTTATGAAAATGAAGTCTGCAAACAAGATTACTTTATTAAATCACCACCTTCTCAGCTGTTCTCCTCTGTGACCTCT TGGAAAAAGCGGTTTTTCATCCTGTCAAAGGCTGGGGAAAAGAGCTTTAGTCTTTCCTATTATAAAGACCATCATCACCGAGGTTCCATT GAAATTGATCAAAATTCCAGTGTAGAAGTTGGCATAAGTAGCCAGGAAAAGATGCAATCTGTGCAGAAGATGTTTAAATGCCACCCTGAT GAGGTCATGTCCATCAGAACCACTAACAGGGAATACTTCCTCATTGGCCACGACAGGGAGAAGATTAAAGACTGGGTCTCCTTCATGTCA TCATTTCGCCAGGATATAAAAGCAACACAGCAGAACACAGAGGAGGAACTCTCATTGGGTAATAAAAGAACCCTCTTCTACTCCAGCCCT CTCCTTGGCCCTTCCAGCACATCAGAGGCTGTTGGCTCCAGCTCACCAAGAAATGGTCTCCAAGACAAGGAGAACTGTGTTTATGAAACT GTAGTTTTGCCTTTGGATGAAAGGGCATTTGAGAAGACTTTAACACCAATCATACAGGAATATTTTGAGCATGGAGATACTAATGAAGTT GCGGAAATGTTAAGAGATTTAAATCTTGGTGAAATGAAAAGTGGAGTACCAGTGTTGGCAGTATCCTTAGCATTGGAGGGGAAGGCTAGT CATAGAGAGATGACATCTAAGCTTCTTTCTGACCTTTGTGGGACAGTAATGAGCACAACTGATGTGGAAAAATCATTTGATAAATTGTTG AAAGATCTACCTGAATTAGCACTGGATACTCCTAGAGCACCACAGTTGGTGGGCCAGTTTATTGCTAGAGCTGTTGGAGATGGAATTTTA TGTAATACCTATATTGATAGTTACAAAGGAACTGTAGATTGTGTGCAGGCTAGAGCTGCTCTGGATAAGGCTACCGTGCTTCTGAGTATG TCTAAAGGTGGAAAGCGTAAAGATAGTGTGTGGGGCTCTGGAGGTGGGCAGCAATCTGTCAATCACCTTGTTAAAGAGATTGATATGCTG CTGAAAGAATATTTACTCTCTGGAGACATATCTGAAGCTGAACATTGCCTTAAGGAACTGGAAGTACCTCATTTTCACCATGAGCTTGTA TATGAAGCTATTATAATGGTTTTAGAGTCAACTGGAGAAAGTACATTTAAGATGATTTTGGATTTATTAAAGTCCCTTTGGAAGTCTTCT ACCATTACTGTAGACCAAATGAAAAGAGGTTATGAGAGAATTTACAATGAAATTCCGGACATTAATCTGGATGTCCCACATTCATACTCT GTGCTGGAGCGGTTTGTAGAAGAATGTTTTCAGGCTGGAATAATTTCCAAACAACTCAGAGATCTTTGTCCTTCAAGGGGCAGAAAGCGT TTTGTAAGCGAAGGAGATGGAGGTCGTCTTAAACCAGAGAGCTACTGAATATAAGAACTCTTGCAGTCTTAGATGTTATAAAAATATATA TCTGAATTGTAAGAGTTGTTAGCACAAGTTTTTTTTTTTTTTTTTTTTAAGCACTTGTTTTGGGTACAAGGCATTTCTGACATTTTATAA ACCTACATTTAAGGGGAATTTTTAAAGGAAATGTTTTTTCTTTTTTTTTTGTTTTTCGAGGGGGCAAGGAGGGACAGAAAAGTAACCTCT TCTTAAGTGGAATATTCTAATAAGCTACCTTTTGTAAGTGCCATGTTTATTATCTAATCATTCCAAGTTTTGCATTGATGTCTGACTGCC ACTCCTTTCTTTCAAGGACAGTGTTTTTTGTAGTAAAATCACTGGTTTATACAAAGCTTTATTTAGGGGGTAAAGTTAAGCTGCTAAAAC CCCATGTTGGCTGCTGCTGTTGAGATACTGTGCTTTGGGAGTAAAAAAAGAAAGTTATTTCTTTGTCTTAAAGAATTTTTAAAAAATTAG TCATGAGACTTATTCATCTTTCCAGGGAACATACTGATTGGTCTTAAAAGACTAGACAGTTAAGTAAAAGGTGGCTGGAACATCTATTTT TCTACAAAACTGGAAAAATGAACCTGGTTCTAGAAGAATGTACACCAAAATAAAACATGTGAAGCAGTATTGATTCTTTATTGGGAGTAC ATTTTTTTAGGTCTCTTAAACTTTAATTTCACACAGTAAATTTTGAATCTCATAAGGAAGCATATTTGAACCTAGTCAATTTAATCTTAG TGTTCCCTTGAAAACTTTTTTTCCCTACAAAATTTTAAGTGAAAAATACAATAGTAAATTAAGATTACACTGGGGAAAAAAATGCAGGTA TCACTTTACTCCATTGTTATCTGACCTAGAGCTTAATTAAGTTTTAGAAATATGTAATACCTTCCATCATTCCATCATCCTTAAATTCTG TTACCAAATAATGGCTAATGTTACAAAAAGTTATACTCCAGAGACCCAAAGCTTGACATTTACCTAATGTATGAGAAAATATTACCAATT AACAATAAAGAATGATCATATTTTTAACCTCTTTTACATAGCCTAATAACTCAGCAAGGCCTCAACGTCTGTGCTAATTTAAACTGCCAA ATATTGACTGCAGCAAACAAGAATTATATTCAGAATTTATGAGGGTACTGTTAGGAGTATACTGCTTACAGGTTTAGATATAGTCTGTTA GAATTAAAACCAAGTTTAGTGTTCATATTTACCTCATGGGCTTTATCAAGCCCATATTACCTCAGCTTATATATAGTTACCATTTTTAGG TTTTTAATTGTTTGACACTTGGATGATAAATGCAGTCATTTTATTCTCAAGTGCTTAAAATTAATGTAATTAAAAGCTTAGCTGACTACA GAATAGGTGAGGGTTTCTTAAAAATGAGATTTAAGGGCTGGGCACGGTGGCTCATGCCTGTAATCCCAGCACTTTGGGAGGCCGAGGTGG GCGGATCACTTGAGGTTGGGAGTTCATGACCAGCTTGACCAACATGAAGAAACCCTGTCTCTATTAAAAATACAAAAGTAGCCAGGCATG GTGGCGCATGCGTGTAATCCCAGCTACTTGGGAGGCTGAGGCAGGAGAATTGCTTGAACCTGGGAGGCAGAGGTTGCAGTGAGTCGAGAT GGTGCCATTGCTCTCGTTTGGGCAACAAGAGTGAAACTCTTGTCTCAAAAAAAAAAAAAAATGAGGTTTAAGACAGTTTTGTCATTACTG GTGGGATCTGGTCACACAAGATAGCATTAAACGTGACATGGCACATAAAATTGGTTAAAAAATTTTGTTTTTTAATTACGTAATGTAAAA >In-frame_PLEKHS1_ENST00000361048_chr10_115529659_+_PDCD4_ENST00000393104_chr10_112645011_+_3765nt ATTATTAATGTGTTTGCTTTCATTTTTGGTGCTAGGCAGCTGGGACACCAAGGAGAGTTCTGTGGCAAGCCACAAGTATGAAGGCCCAGA ACTTCCCCTGAGGGCATAGCTTCCATTTCAGTTTGGGGCAAGAATAAAATCTGCTCAAGGATATTAGTTTGGGAACTTCCTGGTGGTTCA GATTTCAAGCAGAGTTTGTGCTTAATCCTCACCCAGGCACCAAGGCTCAGAGTCAGCAGGAGTGAGTTCAGGAATCCTCGGGACAAGGCA CTTTCCTGAGCACTGGACCAGCGACCTCTTGGCTTCCAGGGAGGACACACAGCCATCATGGAACCCAAACCTCAGAAGAGTCCAGGCAAA CAATTTACATTTTCTTATGAAAATGAAGTCTGCAAACAAGATTACTTTATTAAATCACCACCTTCTCAGCTGTTCTCCTCTGTGACCTCT TGGAAAAAGCGGTTTTTCATCCTGTCAAAGGCTGGGGAAAAGAGCTTTAGTCTTTCCTATTATAAAGACCATCATCACCGAGGTTCCATT GAAATTGATCAAAATTCCAGTGTAGAAGTTGGCATAAGTAGCCAGGAAAAGATGCAATCTGTGCAGAAGATGTTTAAATGCCACCCTGAT GAGGTCATGTCCATCAGAACCACTAACAGGGAATACTTCCTCATTGGCCACGACAGGGAGAAGATTAAAGACTGGGTCTCCTTCATGTCA TCATTTCGCCAGGATATAAAAGCAACACAGCAGAACACAGAGGAGGAACTCTCATTGGGTAATAAAAGAACCCTCTTCTACTCCAGCCCT CTCCTTGGCCCTTCCAGCACATCAGAGGCTGTTGGCTCCAGCTCACCAAGAAATGGTCTCCAAGACAAGGAGAACTGTGTTTATGAAACT GTAGTTTTGCCTTTGGATGAAAGGGCATTTGAGAAGACTTTAACACCAATCATACAGGAATATTTTGAGCATGGAGATACTAATGAAGTT GCGGAAATGTTAAGAGATTTAAATCTTGGTGAAATGAAAAGTGGAGTACCAGTGTTGGCAGTATCCTTAGCATTGGAGGGGAAGGCTAGT CATAGAGAGATGACATCTAAGCTTCTTTCTGACCTTTGTGGGACAGTAATGAGCACAACTGATGTGGAAAAATCATTTGATAAATTGTTG AAAGATCTACCTGAATTAGCACTGGATACTCCTAGAGCACCACAGTTGGTGGGCCAGTTTATTGCTAGAGCTGTTGGAGATGGAATTTTA TGTAATACCTATATTGATAGTTACAAAGGAACTGTAGATTGTGTGCAGGCTAGAGCTGCTCTGGATAAGGCTACCGTGCTTCTGAGTATG TCTAAAGGTGGAAAGCGTAAAGATAGTGTGTGGGGCTCTGGAGGTGGGCAGCAATCTGTCAATCACCTTGTTAAAGAGATTGATATGCTG CTGAAAGAATATTTACTCTCTGGAGACATATCTGAAGCTGAACATTGCCTTAAGGAACTGGAAGTACCTCATTTTCACCATGAGCTTGTA TATGAAGCTATTATAATGGTTTTAGAGTCAACTGGAGAAAGTACATTTAAGATGATTTTGGATTTATTAAAGTCCCTTTGGAAGTCTTCT ACCATTACTGTAGACCAAATGAAAAGAGGTTATGAGAGAATTTACAATGAAATTCCGGACATTAATCTGGATGTCCCACATTCATACTCT GTGCTGGAGCGGTTTGTAGAAGAATGTTTTCAGGCTGGAATAATTTCCAAACAACTCAGAGATCTTTGTCCTTCAAGGGGCAGAAAGCGT TTTGTAAGCGAAGGAGATGGAGGTCGTCTTAAACCAGAGAGCTACTGAATATAAGAACTCTTGCAGTCTTAGATGTTATAAAAATATATA TCTGAATTGTAAGAGTTGTTAGCACAAGTTTTTTTTTTTTTTTTTTTTAAGCACTTGTTTTGGGTACAAGGCATTTCTGACATTTTATAA ACCTACATTTAAGGGGAATTTTTAAAGGAAATGTTTTTTCTTTTTTTTTTGTTTTTCGAGGGGGCAAGGAGGGACAGAAAAGTAACCTCT TCTTAAGTGGAATATTCTAATAAGCTACCTTTTGTAAGTGCCATGTTTATTATCTAATCATTCCAAGTTTTGCATTGATGTCTGACTGCC ACTCCTTTCTTTCAAGGACAGTGTTTTTTGTAGTAAAATCACTGGTTTATACAAAGCTTTATTTAGGGGGTAAAGTTAAGCTGCTAAAAC CCCATGTTGGCTGCTGCTGTTGAGATACTGTGCTTTGGGAGTAAAAAAAGAAAGTTATTTCTTTGTCTTAAAGAATTTTTAAAAAATTAG TCATGAGACTTATTCATCTTTCCAGGGAACATACTGATTGGTCTTAAAAGACTAGACAGTTAAGTAAAAGGTGGCTGGAACATCTATTTT TCTACAAAACTGGAAAAATGAACCTGGTTCTAGAAGAATGTACACCAAAATAAAACATGTGAAGCAGTATTGATTCTTTATTGGGAGTAC ATTTTTTTAGGTCTCTTAAACTTTAATTTCACACAGTAAATTTTGAATCTCATAAGGAAGCATATTTGAACCTAGTCAATTTAATCTTAG TGTTCCCTTGAAAACTTTTTTTCCCTACAAAATTTTAAGTGAAAAATACAATAGTAAATTAAGATTACACTGGGGAAAAAAATGCAGGTA TCACTTTACTCCATTGTTATCTGACCTAGAGCTTAATTAAGTTTTAGAAATATGTAATACCTTCCATCATTCCATCATCCTTAAATTCTG TTACCAAATAATGGCTAATGTTACAAAAAGTTATACTCCAGAGACCCAAAGCTTGACATTTACCTAATGTATGAGAAAATATTACCAATT AACAATAAAGAATGATCATATTTTTAACCTCTTTTACATAGCCTAATAACTCAGCAAGGCCTCAACGTCTGTGCTAATTTAAACTGCCAA ATATTGACTGCAGCAAACAAGAATTATATTCAGAATTTATGAGGGTACTGTTAGGAGTATACTGCTTACAGGTTTAGATATAGTCTGTTA GAATTAAAACCAAGTTTAGTGTTCATATTTACCTCATGGGCTTTATCAAGCCCATATTACCTCAGCTTATATATAGTTACCATTTTTAGG TTTTTAATTGTTTGACACTTGGATGATAAATGCAGTCATTTTATTCTCAAGTGCTTAAAATTAATGTAATTAAAAGCTTAGCTGACTACA GAATAGGTGAGGGTTTCTTAAAAATGAGATTTAAGGGCTGGGCACGGTGGCTCATGCCTGTAATCCCAGCACTTTGGGAGGCCGAGGTGG GCGGATCACTTGAGGTTGGGAGTTCATGACCAGCTTGACCAACATGAAGAAACCCTGTCTCTATTAAAAATACAAAAGTAGCCAGGCATG GTGGCGCATGCGTGTAATCCCAGCTACTTGGGAGGCTGAGGCAGGAGAATTGCTTGAACCTGGGAGGCAGAGGTTGCAGTGAGTCGAGAT GGTGCCATTGCTCTCGTTTGGGCAACAAGAGTGAAACTCTTGTCTCAAAAAAAAAAAAAAATGAGGTTTAAGACAGTTTTGTCATTACTG GTGGGATCTGGTCACACAAGATAGCATTAAACGTGACATGGCACATAAAATTGGTTAAAAAATTTTGTTTTTTAATTACGTAATGTAAAA >In-frame_PLEKHS1_ENST00000369312_chr10_115529659_+_PDCD4_ENST00000280154_chr10_112645011_+_3638nt AGAGTCAGCAGGAGTGAGTTCAGGAATCCTCGGGACAAGGCACTTTCCTGAGCACTGGACCAGCGACCTCTTGGCTTCCAGGGAGGACAC ACAGCCATCATGGAACCCAAACCTCAGAAGAGTCCAGGTACCCGAGGGGTATAATCGCAGAAGCAGAAATCTTTTTATTGAAAATGCCCC ACGGTTTCCTTCAAGCTAACCAGGATACAGAACTTGGTGGTTTTTGTGCAAACAATTTACATTTTCTTATGAAAATGAAGTCTGCAAACA AGATTACTTTATTAAATCACCACCTTCTCAGCTGTTCTCCTCTGTGACCTCTTGGAAAAAGCGGTTTTTCATCCTGTCAAAGGCTGGGGA AAAGAGCTTTAGTCTTTCCTATTATAAAGACCATCATCACCGAGGTTCCATTGAAATTGATCAAAATTCCAGTGTAGAAGTTGGCATAAG TAGCCAGGAAAAGATGCAATCTGTGCAGAAGATGTTTAAATGCCACCCTGATGAGGTCATGTCCATCAGAACCACTAACAGGGAATACTT CCTCATTGGCCACGACAGGGAGAAGATTAAAGACTGGGTCTCCTTCATGTCATCATTTCGCCAGGATATAAAAGCAACACAGCAGAACAC AGAGGAGGAACTCTCATTGGGTAATAAAAGAACCCTCTTCTACTCCAGCCCTCTCCTTGGCCCTTCCAGCACATCAGAGGCTGTTGGCTC CAGCTCACCAAGAAATGGTCTCCAAGACAAGGAGAACTGTGTTTATGAAACTGTAGTTTTGCCTTTGGATGAAAGGGCATTTGAGAAGAC TTTAACACCAATCATACAGGAATATTTTGAGCATGGAGATACTAATGAAGTTGCGGAAATGTTAAGAGATTTAAATCTTGGTGAAATGAA AAGTGGAGTACCAGTGTTGGCAGTATCCTTAGCATTGGAGGGGAAGGCTAGTCATAGAGAGATGACATCTAAGCTTCTTTCTGACCTTTG TGGGACAGTAATGAGCACAACTGATGTGGAAAAATCATTTGATAAATTGTTGAAAGATCTACCTGAATTAGCACTGGATACTCCTAGAGC ACCACAGTTGGTGGGCCAGTTTATTGCTAGAGCTGTTGGAGATGGAATTTTATGTAATACCTATATTGATAGTTACAAAGGAACTGTAGA TTGTGTGCAGGCTAGAGCTGCTCTGGATAAGGCTACCGTGCTTCTGAGTATGTCTAAAGGTGGAAAGCGTAAAGATAGTGTGTGGGGCTC TGGAGGTGGGCAGCAATCTGTCAATCACCTTGTTAAAGAGATTGATATGCTGCTGAAAGAATATTTACTCTCTGGAGACATATCTGAAGC TGAACATTGCCTTAAGGAACTGGAAGTACCTCATTTTCACCATGAGCTTGTATATGAAGCTATTATAATGGTTTTAGAGTCAACTGGAGA AAGTACATTTAAGATGATTTTGGATTTATTAAAGTCCCTTTGGAAGTCTTCTACCATTACTGTAGACCAAATGAAAAGAGGTTATGAGAG AATTTACAATGAAATTCCGGACATTAATCTGGATGTCCCACATTCATACTCTGTGCTGGAGCGGTTTGTAGAAGAATGTTTTCAGGCTGG AATAATTTCCAAACAACTCAGAGATCTTTGTCCTTCAAGGGGCAGAAAGCGTTTTGTAAGCGAAGGAGATGGAGGTCGTCTTAAACCAGA GAGCTACTGAATATAAGAACTCTTGCAGTCTTAGATGTTATAAAAATATATATCTGAATTGTAAGAGTTGTTAGCACAAGTTTTTTTTTT TTTTTTTTTTAAGCACTTGTTTTGGGTACAAGGCATTTCTGACATTTTATAAACCTACATTTAAGGGGAATTTTTAAAGGAAATGTTTTT TCTTTTTTTTTTGTTTTTCGAGGGGGCAAGGAGGGACAGAAAAGTAACCTCTTCTTAAGTGGAATATTCTAATAAGCTACCTTTTGTAAG TGCCATGTTTATTATCTAATCATTCCAAGTTTTGCATTGATGTCTGACTGCCACTCCTTTCTTTCAAGGACAGTGTTTTTTGTAGTAAAA TCACTGGTTTATACAAAGCTTTATTTAGGGGGTAAAGTTAAGCTGCTAAAACCCCATGTTGGCTGCTGCTGTTGAGATACTGTGCTTTGG GAGTAAAAAAAGAAAGTTATTTCTTTGTCTTAAAGAATTTTTAAAAAATTAGTCATGAGACTTATTCATCTTTCCAGGGAACATACTGAT TGGTCTTAAAAGACTAGACAGTTAAGTAAAAGGTGGCTGGAACATCTATTTTTCTACAAAACTGGAAAAATGAACCTGGTTCTAGAAGAA TGTACACCAAAATAAAACATGTGAAGCAGTATTGATTCTTTATTGGGAGTACATTTTTTTAGGTCTCTTAAACTTTAATTTCACACAGTA AATTTTGAATCTCATAAGGAAGCATATTTGAACCTAGTCAATTTAATCTTAGTGTTCCCTTGAAAACTTTTTTTCCCTACAAAATTTTAA GTGAAAAATACAATAGTAAATTAAGATTACACTGGGGAAAAAAATGCAGGTATCACTTTACTCCATTGTTATCTGACCTAGAGCTTAATT AAGTTTTAGAAATATGTAATACCTTCCATCATTCCATCATCCTTAAATTCTGTTACCAAATAATGGCTAATGTTACAAAAAGTTATACTC CAGAGACCCAAAGCTTGACATTTACCTAATGTATGAGAAAATATTACCAATTAACAATAAAGAATGATCATATTTTTAACCTCTTTTACA TAGCCTAATAACTCAGCAAGGCCTCAACGTCTGTGCTAATTTAAACTGCCAAATATTGACTGCAGCAAACAAGAATTATATTCAGAATTT ATGAGGGTACTGTTAGGAGTATACTGCTTACAGGTTTAGATATAGTCTGTTAGAATTAAAACCAAGTTTAGTGTTCATATTTACCTCATG GGCTTTATCAAGCCCATATTACCTCAGCTTATATATAGTTACCATTTTTAGGTTTTTAATTGTTTGACACTTGGATGATAAATGCAGTCA TTTTATTCTCAAGTGCTTAAAATTAATGTAATTAAAAGCTTAGCTGACTACAGAATAGGTGAGGGTTTCTTAAAAATGAGATTTAAGGGC TGGGCACGGTGGCTCATGCCTGTAATCCCAGCACTTTGGGAGGCCGAGGTGGGCGGATCACTTGAGGTTGGGAGTTCATGACCAGCTTGA CCAACATGAAGAAACCCTGTCTCTATTAAAAATACAAAAGTAGCCAGGCATGGTGGCGCATGCGTGTAATCCCAGCTACTTGGGAGGCTG AGGCAGGAGAATTGCTTGAACCTGGGAGGCAGAGGTTGCAGTGAGTCGAGATGGTGCCATTGCTCTCGTTTGGGCAACAAGAGTGAAACT CTTGTCTCAAAAAAAAAAAAAAATGAGGTTTAAGACAGTTTTGTCATTACTGGTGGGATCTGGTCACACAAGATAGCATTAAACGTGACA TGGCACATAAAATTGGTTAAAAAATTTTGTTTTTTAATTACGTAATGTAAAAGCCCAACAAACACTTTATGCAAGATTGGAATGTATCTT >In-frame_PLEKHS1_ENST00000369312_chr10_115529659_+_PDCD4_ENST00000393104_chr10_112645011_+_3637nt AGAGTCAGCAGGAGTGAGTTCAGGAATCCTCGGGACAAGGCACTTTCCTGAGCACTGGACCAGCGACCTCTTGGCTTCCAGGGAGGACAC ACAGCCATCATGGAACCCAAACCTCAGAAGAGTCCAGGTACCCGAGGGGTATAATCGCAGAAGCAGAAATCTTTTTATTGAAAATGCCCC ACGGTTTCCTTCAAGCTAACCAGGATACAGAACTTGGTGGTTTTTGTGCAAACAATTTACATTTTCTTATGAAAATGAAGTCTGCAAACA AGATTACTTTATTAAATCACCACCTTCTCAGCTGTTCTCCTCTGTGACCTCTTGGAAAAAGCGGTTTTTCATCCTGTCAAAGGCTGGGGA AAAGAGCTTTAGTCTTTCCTATTATAAAGACCATCATCACCGAGGTTCCATTGAAATTGATCAAAATTCCAGTGTAGAAGTTGGCATAAG TAGCCAGGAAAAGATGCAATCTGTGCAGAAGATGTTTAAATGCCACCCTGATGAGGTCATGTCCATCAGAACCACTAACAGGGAATACTT CCTCATTGGCCACGACAGGGAGAAGATTAAAGACTGGGTCTCCTTCATGTCATCATTTCGCCAGGATATAAAAGCAACACAGCAGAACAC AGAGGAGGAACTCTCATTGGGTAATAAAAGAACCCTCTTCTACTCCAGCCCTCTCCTTGGCCCTTCCAGCACATCAGAGGCTGTTGGCTC CAGCTCACCAAGAAATGGTCTCCAAGACAAGGAGAACTGTGTTTATGAAACTGTAGTTTTGCCTTTGGATGAAAGGGCATTTGAGAAGAC TTTAACACCAATCATACAGGAATATTTTGAGCATGGAGATACTAATGAAGTTGCGGAAATGTTAAGAGATTTAAATCTTGGTGAAATGAA AAGTGGAGTACCAGTGTTGGCAGTATCCTTAGCATTGGAGGGGAAGGCTAGTCATAGAGAGATGACATCTAAGCTTCTTTCTGACCTTTG TGGGACAGTAATGAGCACAACTGATGTGGAAAAATCATTTGATAAATTGTTGAAAGATCTACCTGAATTAGCACTGGATACTCCTAGAGC ACCACAGTTGGTGGGCCAGTTTATTGCTAGAGCTGTTGGAGATGGAATTTTATGTAATACCTATATTGATAGTTACAAAGGAACTGTAGA TTGTGTGCAGGCTAGAGCTGCTCTGGATAAGGCTACCGTGCTTCTGAGTATGTCTAAAGGTGGAAAGCGTAAAGATAGTGTGTGGGGCTC TGGAGGTGGGCAGCAATCTGTCAATCACCTTGTTAAAGAGATTGATATGCTGCTGAAAGAATATTTACTCTCTGGAGACATATCTGAAGC TGAACATTGCCTTAAGGAACTGGAAGTACCTCATTTTCACCATGAGCTTGTATATGAAGCTATTATAATGGTTTTAGAGTCAACTGGAGA AAGTACATTTAAGATGATTTTGGATTTATTAAAGTCCCTTTGGAAGTCTTCTACCATTACTGTAGACCAAATGAAAAGAGGTTATGAGAG AATTTACAATGAAATTCCGGACATTAATCTGGATGTCCCACATTCATACTCTGTGCTGGAGCGGTTTGTAGAAGAATGTTTTCAGGCTGG AATAATTTCCAAACAACTCAGAGATCTTTGTCCTTCAAGGGGCAGAAAGCGTTTTGTAAGCGAAGGAGATGGAGGTCGTCTTAAACCAGA GAGCTACTGAATATAAGAACTCTTGCAGTCTTAGATGTTATAAAAATATATATCTGAATTGTAAGAGTTGTTAGCACAAGTTTTTTTTTT TTTTTTTTTTAAGCACTTGTTTTGGGTACAAGGCATTTCTGACATTTTATAAACCTACATTTAAGGGGAATTTTTAAAGGAAATGTTTTT TCTTTTTTTTTTGTTTTTCGAGGGGGCAAGGAGGGACAGAAAAGTAACCTCTTCTTAAGTGGAATATTCTAATAAGCTACCTTTTGTAAG TGCCATGTTTATTATCTAATCATTCCAAGTTTTGCATTGATGTCTGACTGCCACTCCTTTCTTTCAAGGACAGTGTTTTTTGTAGTAAAA TCACTGGTTTATACAAAGCTTTATTTAGGGGGTAAAGTTAAGCTGCTAAAACCCCATGTTGGCTGCTGCTGTTGAGATACTGTGCTTTGG GAGTAAAAAAAGAAAGTTATTTCTTTGTCTTAAAGAATTTTTAAAAAATTAGTCATGAGACTTATTCATCTTTCCAGGGAACATACTGAT TGGTCTTAAAAGACTAGACAGTTAAGTAAAAGGTGGCTGGAACATCTATTTTTCTACAAAACTGGAAAAATGAACCTGGTTCTAGAAGAA TGTACACCAAAATAAAACATGTGAAGCAGTATTGATTCTTTATTGGGAGTACATTTTTTTAGGTCTCTTAAACTTTAATTTCACACAGTA AATTTTGAATCTCATAAGGAAGCATATTTGAACCTAGTCAATTTAATCTTAGTGTTCCCTTGAAAACTTTTTTTCCCTACAAAATTTTAA GTGAAAAATACAATAGTAAATTAAGATTACACTGGGGAAAAAAATGCAGGTATCACTTTACTCCATTGTTATCTGACCTAGAGCTTAATT AAGTTTTAGAAATATGTAATACCTTCCATCATTCCATCATCCTTAAATTCTGTTACCAAATAATGGCTAATGTTACAAAAAGTTATACTC CAGAGACCCAAAGCTTGACATTTACCTAATGTATGAGAAAATATTACCAATTAACAATAAAGAATGATCATATTTTTAACCTCTTTTACA TAGCCTAATAACTCAGCAAGGCCTCAACGTCTGTGCTAATTTAAACTGCCAAATATTGACTGCAGCAAACAAGAATTATATTCAGAATTT ATGAGGGTACTGTTAGGAGTATACTGCTTACAGGTTTAGATATAGTCTGTTAGAATTAAAACCAAGTTTAGTGTTCATATTTACCTCATG GGCTTTATCAAGCCCATATTACCTCAGCTTATATATAGTTACCATTTTTAGGTTTTTAATTGTTTGACACTTGGATGATAAATGCAGTCA TTTTATTCTCAAGTGCTTAAAATTAATGTAATTAAAAGCTTAGCTGACTACAGAATAGGTGAGGGTTTCTTAAAAATGAGATTTAAGGGC TGGGCACGGTGGCTCATGCCTGTAATCCCAGCACTTTGGGAGGCCGAGGTGGGCGGATCACTTGAGGTTGGGAGTTCATGACCAGCTTGA CCAACATGAAGAAACCCTGTCTCTATTAAAAATACAAAAGTAGCCAGGCATGGTGGCGCATGCGTGTAATCCCAGCTACTTGGGAGGCTG AGGCAGGAGAATTGCTTGAACCTGGGAGGCAGAGGTTGCAGTGAGTCGAGATGGTGCCATTGCTCTCGTTTGGGCAACAAGAGTGAAACT CTTGTCTCAAAAAAAAAAAAAAATGAGGTTTAAGACAGTTTTGTCATTACTGGTGGGATCTGGTCACACAAGATAGCATTAAACGTGACA TGGCACATAAAATTGGTTAAAAAATTTTGTTTTTTAATTACGTAATGTAAAAGCCCAACAAACACTTTATGCAAGATTGGAATGTATCTT >In-frame_PLEKHS1_ENST00000369310_chr10_115529659_+_PDCD4_ENST00000280154_chr10_112645011_+_3983nt ATGCCTTTAAGTGCACTAATCTTTTCTTGTACAATATTTAATCTGCTCTTACTCCCATCCAGTGTTGTTGCTGTTTTTTTGAGACATTGT AGTTTTCATCTTTAAAATTTCACTTTAGGTCTTCTTTATATCTTTTATATCTCTCCCTAACTTTTTGAAAATATAGTGATAATAACTGCT TTAATTACTTTCTCTGCCAATTCTAACATCTGTGTCAGTTCTAGGCCTGTTTTGATTGATTGACTTTCTTCTCATTATTGATCATGTTTT CCTTCCTCTTTGTATGCCTGGTAAACTTTGATTGACTGCCAAACATCGCAAATTTTACCTTGTTGTTTCCTGAATATCTTTGTATTCCTA TGAATCTTGAGCTTTGTTCTGGGATACAGTTAAATTTTTTGGGAACAACTTTCTTCTAAGTCTTTCATGATTTTTTAGGTGGGTTTGGAG CAGTGCTCAGTGTAGAACTAGTAATTAGTGTAGAGCTAATTATTCCTCACACTGAGGCAAGACATTCCTGAGTACTCTACCCAATGCCCT GTAAATTATAAGTTTTTCCAGTATGGCTGGAGGCAAACAATTTACATTTTCTTATGAAAATGAAGTCTGCAAACAAGATTACTTTATTAA ATCACCACCTTCTCAGCTGTTCTCCTCTGTGACCTCTTGGAAAAAGCGGTTTTTCATCCTGTCAAAGGCTGGGGAAAAGAGCTTTAGTCT TTCCTATTATAAAGACCATCATCACCGAGGTTCCATTGAAATTGATCAAAATTCCAGTGTAGAAGTTGGCATAAGTAGCCAGGAAAAGAT GCAATCTGTGCAGAAGATGTTTAAATGCCACCCTGATGAGGTCATGTCCATCAGAACCACTAACAGGGAATACTTCCTCATTGGCCACGA CAGGGAGAAGATTAAAGACTGGGTCTCCTTCATGTCATCATTTCGCCAGGATATAAAAGCAACACAGCAGAACACAGAGGAGGAACTCTC ATTGGGTAATAAAAGAACCCTCTTCTACTCCAGCCCTCTCCTTGGCCCTTCCAGCACATCAGAGGCTGTTGGCTCCAGCTCACCAAGAAA TGGTCTCCAAGACAAGGAGAACTGTGTTTATGAAACTGTAGTTTTGCCTTTGGATGAAAGGGCATTTGAGAAGACTTTAACACCAATCAT ACAGGAATATTTTGAGCATGGAGATACTAATGAAGTTGCGGAAATGTTAAGAGATTTAAATCTTGGTGAAATGAAAAGTGGAGTACCAGT GTTGGCAGTATCCTTAGCATTGGAGGGGAAGGCTAGTCATAGAGAGATGACATCTAAGCTTCTTTCTGACCTTTGTGGGACAGTAATGAG CACAACTGATGTGGAAAAATCATTTGATAAATTGTTGAAAGATCTACCTGAATTAGCACTGGATACTCCTAGAGCACCACAGTTGGTGGG CCAGTTTATTGCTAGAGCTGTTGGAGATGGAATTTTATGTAATACCTATATTGATAGTTACAAAGGAACTGTAGATTGTGTGCAGGCTAG AGCTGCTCTGGATAAGGCTACCGTGCTTCTGAGTATGTCTAAAGGTGGAAAGCGTAAAGATAGTGTGTGGGGCTCTGGAGGTGGGCAGCA ATCTGTCAATCACCTTGTTAAAGAGATTGATATGCTGCTGAAAGAATATTTACTCTCTGGAGACATATCTGAAGCTGAACATTGCCTTAA GGAACTGGAAGTACCTCATTTTCACCATGAGCTTGTATATGAAGCTATTATAATGGTTTTAGAGTCAACTGGAGAAAGTACATTTAAGAT GATTTTGGATTTATTAAAGTCCCTTTGGAAGTCTTCTACCATTACTGTAGACCAAATGAAAAGAGGTTATGAGAGAATTTACAATGAAAT TCCGGACATTAATCTGGATGTCCCACATTCATACTCTGTGCTGGAGCGGTTTGTAGAAGAATGTTTTCAGGCTGGAATAATTTCCAAACA ACTCAGAGATCTTTGTCCTTCAAGGGGCAGAAAGCGTTTTGTAAGCGAAGGAGATGGAGGTCGTCTTAAACCAGAGAGCTACTGAATATA AGAACTCTTGCAGTCTTAGATGTTATAAAAATATATATCTGAATTGTAAGAGTTGTTAGCACAAGTTTTTTTTTTTTTTTTTTTTAAGCA CTTGTTTTGGGTACAAGGCATTTCTGACATTTTATAAACCTACATTTAAGGGGAATTTTTAAAGGAAATGTTTTTTCTTTTTTTTTTGTT TTTCGAGGGGGCAAGGAGGGACAGAAAAGTAACCTCTTCTTAAGTGGAATATTCTAATAAGCTACCTTTTGTAAGTGCCATGTTTATTAT CTAATCATTCCAAGTTTTGCATTGATGTCTGACTGCCACTCCTTTCTTTCAAGGACAGTGTTTTTTGTAGTAAAATCACTGGTTTATACA AAGCTTTATTTAGGGGGTAAAGTTAAGCTGCTAAAACCCCATGTTGGCTGCTGCTGTTGAGATACTGTGCTTTGGGAGTAAAAAAAGAAA GTTATTTCTTTGTCTTAAAGAATTTTTAAAAAATTAGTCATGAGACTTATTCATCTTTCCAGGGAACATACTGATTGGTCTTAAAAGACT AGACAGTTAAGTAAAAGGTGGCTGGAACATCTATTTTTCTACAAAACTGGAAAAATGAACCTGGTTCTAGAAGAATGTACACCAAAATAA AACATGTGAAGCAGTATTGATTCTTTATTGGGAGTACATTTTTTTAGGTCTCTTAAACTTTAATTTCACACAGTAAATTTTGAATCTCAT AAGGAAGCATATTTGAACCTAGTCAATTTAATCTTAGTGTTCCCTTGAAAACTTTTTTTCCCTACAAAATTTTAAGTGAAAAATACAATA GTAAATTAAGATTACACTGGGGAAAAAAATGCAGGTATCACTTTACTCCATTGTTATCTGACCTAGAGCTTAATTAAGTTTTAGAAATAT GTAATACCTTCCATCATTCCATCATCCTTAAATTCTGTTACCAAATAATGGCTAATGTTACAAAAAGTTATACTCCAGAGACCCAAAGCT TGACATTTACCTAATGTATGAGAAAATATTACCAATTAACAATAAAGAATGATCATATTTTTAACCTCTTTTACATAGCCTAATAACTCA GCAAGGCCTCAACGTCTGTGCTAATTTAAACTGCCAAATATTGACTGCAGCAAACAAGAATTATATTCAGAATTTATGAGGGTACTGTTA GGAGTATACTGCTTACAGGTTTAGATATAGTCTGTTAGAATTAAAACCAAGTTTAGTGTTCATATTTACCTCATGGGCTTTATCAAGCCC ATATTACCTCAGCTTATATATAGTTACCATTTTTAGGTTTTTAATTGTTTGACACTTGGATGATAAATGCAGTCATTTTATTCTCAAGTG CTTAAAATTAATGTAATTAAAAGCTTAGCTGACTACAGAATAGGTGAGGGTTTCTTAAAAATGAGATTTAAGGGCTGGGCACGGTGGCTC ATGCCTGTAATCCCAGCACTTTGGGAGGCCGAGGTGGGCGGATCACTTGAGGTTGGGAGTTCATGACCAGCTTGACCAACATGAAGAAAC CCTGTCTCTATTAAAAATACAAAAGTAGCCAGGCATGGTGGCGCATGCGTGTAATCCCAGCTACTTGGGAGGCTGAGGCAGGAGAATTGC TTGAACCTGGGAGGCAGAGGTTGCAGTGAGTCGAGATGGTGCCATTGCTCTCGTTTGGGCAACAAGAGTGAAACTCTTGTCTCAAAAAAA AAAAAAAATGAGGTTTAAGACAGTTTTGTCATTACTGGTGGGATCTGGTCACACAAGATAGCATTAAACGTGACATGGCACATAAAATTG GTTAAAAAATTTTGTTTTTTAATTACGTAATGTAAAAGCCCAACAAACACTTTATGCAAGATTGGAATGTATCTTCAAATTCAGATTTAA >In-frame_PLEKHS1_ENST00000369310_chr10_115529659_+_PDCD4_ENST00000393104_chr10_112645011_+_3982nt ATGCCTTTAAGTGCACTAATCTTTTCTTGTACAATATTTAATCTGCTCTTACTCCCATCCAGTGTTGTTGCTGTTTTTTTGAGACATTGT AGTTTTCATCTTTAAAATTTCACTTTAGGTCTTCTTTATATCTTTTATATCTCTCCCTAACTTTTTGAAAATATAGTGATAATAACTGCT TTAATTACTTTCTCTGCCAATTCTAACATCTGTGTCAGTTCTAGGCCTGTTTTGATTGATTGACTTTCTTCTCATTATTGATCATGTTTT CCTTCCTCTTTGTATGCCTGGTAAACTTTGATTGACTGCCAAACATCGCAAATTTTACCTTGTTGTTTCCTGAATATCTTTGTATTCCTA TGAATCTTGAGCTTTGTTCTGGGATACAGTTAAATTTTTTGGGAACAACTTTCTTCTAAGTCTTTCATGATTTTTTAGGTGGGTTTGGAG CAGTGCTCAGTGTAGAACTAGTAATTAGTGTAGAGCTAATTATTCCTCACACTGAGGCAAGACATTCCTGAGTACTCTACCCAATGCCCT GTAAATTATAAGTTTTTCCAGTATGGCTGGAGGCAAACAATTTACATTTTCTTATGAAAATGAAGTCTGCAAACAAGATTACTTTATTAA ATCACCACCTTCTCAGCTGTTCTCCTCTGTGACCTCTTGGAAAAAGCGGTTTTTCATCCTGTCAAAGGCTGGGGAAAAGAGCTTTAGTCT TTCCTATTATAAAGACCATCATCACCGAGGTTCCATTGAAATTGATCAAAATTCCAGTGTAGAAGTTGGCATAAGTAGCCAGGAAAAGAT GCAATCTGTGCAGAAGATGTTTAAATGCCACCCTGATGAGGTCATGTCCATCAGAACCACTAACAGGGAATACTTCCTCATTGGCCACGA CAGGGAGAAGATTAAAGACTGGGTCTCCTTCATGTCATCATTTCGCCAGGATATAAAAGCAACACAGCAGAACACAGAGGAGGAACTCTC ATTGGGTAATAAAAGAACCCTCTTCTACTCCAGCCCTCTCCTTGGCCCTTCCAGCACATCAGAGGCTGTTGGCTCCAGCTCACCAAGAAA TGGTCTCCAAGACAAGGAGAACTGTGTTTATGAAACTGTAGTTTTGCCTTTGGATGAAAGGGCATTTGAGAAGACTTTAACACCAATCAT ACAGGAATATTTTGAGCATGGAGATACTAATGAAGTTGCGGAAATGTTAAGAGATTTAAATCTTGGTGAAATGAAAAGTGGAGTACCAGT GTTGGCAGTATCCTTAGCATTGGAGGGGAAGGCTAGTCATAGAGAGATGACATCTAAGCTTCTTTCTGACCTTTGTGGGACAGTAATGAG CACAACTGATGTGGAAAAATCATTTGATAAATTGTTGAAAGATCTACCTGAATTAGCACTGGATACTCCTAGAGCACCACAGTTGGTGGG CCAGTTTATTGCTAGAGCTGTTGGAGATGGAATTTTATGTAATACCTATATTGATAGTTACAAAGGAACTGTAGATTGTGTGCAGGCTAG AGCTGCTCTGGATAAGGCTACCGTGCTTCTGAGTATGTCTAAAGGTGGAAAGCGTAAAGATAGTGTGTGGGGCTCTGGAGGTGGGCAGCA ATCTGTCAATCACCTTGTTAAAGAGATTGATATGCTGCTGAAAGAATATTTACTCTCTGGAGACATATCTGAAGCTGAACATTGCCTTAA GGAACTGGAAGTACCTCATTTTCACCATGAGCTTGTATATGAAGCTATTATAATGGTTTTAGAGTCAACTGGAGAAAGTACATTTAAGAT GATTTTGGATTTATTAAAGTCCCTTTGGAAGTCTTCTACCATTACTGTAGACCAAATGAAAAGAGGTTATGAGAGAATTTACAATGAAAT TCCGGACATTAATCTGGATGTCCCACATTCATACTCTGTGCTGGAGCGGTTTGTAGAAGAATGTTTTCAGGCTGGAATAATTTCCAAACA ACTCAGAGATCTTTGTCCTTCAAGGGGCAGAAAGCGTTTTGTAAGCGAAGGAGATGGAGGTCGTCTTAAACCAGAGAGCTACTGAATATA AGAACTCTTGCAGTCTTAGATGTTATAAAAATATATATCTGAATTGTAAGAGTTGTTAGCACAAGTTTTTTTTTTTTTTTTTTTTAAGCA CTTGTTTTGGGTACAAGGCATTTCTGACATTTTATAAACCTACATTTAAGGGGAATTTTTAAAGGAAATGTTTTTTCTTTTTTTTTTGTT TTTCGAGGGGGCAAGGAGGGACAGAAAAGTAACCTCTTCTTAAGTGGAATATTCTAATAAGCTACCTTTTGTAAGTGCCATGTTTATTAT CTAATCATTCCAAGTTTTGCATTGATGTCTGACTGCCACTCCTTTCTTTCAAGGACAGTGTTTTTTGTAGTAAAATCACTGGTTTATACA AAGCTTTATTTAGGGGGTAAAGTTAAGCTGCTAAAACCCCATGTTGGCTGCTGCTGTTGAGATACTGTGCTTTGGGAGTAAAAAAAGAAA GTTATTTCTTTGTCTTAAAGAATTTTTAAAAAATTAGTCATGAGACTTATTCATCTTTCCAGGGAACATACTGATTGGTCTTAAAAGACT AGACAGTTAAGTAAAAGGTGGCTGGAACATCTATTTTTCTACAAAACTGGAAAAATGAACCTGGTTCTAGAAGAATGTACACCAAAATAA AACATGTGAAGCAGTATTGATTCTTTATTGGGAGTACATTTTTTTAGGTCTCTTAAACTTTAATTTCACACAGTAAATTTTGAATCTCAT AAGGAAGCATATTTGAACCTAGTCAATTTAATCTTAGTGTTCCCTTGAAAACTTTTTTTCCCTACAAAATTTTAAGTGAAAAATACAATA GTAAATTAAGATTACACTGGGGAAAAAAATGCAGGTATCACTTTACTCCATTGTTATCTGACCTAGAGCTTAATTAAGTTTTAGAAATAT GTAATACCTTCCATCATTCCATCATCCTTAAATTCTGTTACCAAATAATGGCTAATGTTACAAAAAGTTATACTCCAGAGACCCAAAGCT TGACATTTACCTAATGTATGAGAAAATATTACCAATTAACAATAAAGAATGATCATATTTTTAACCTCTTTTACATAGCCTAATAACTCA GCAAGGCCTCAACGTCTGTGCTAATTTAAACTGCCAAATATTGACTGCAGCAAACAAGAATTATATTCAGAATTTATGAGGGTACTGTTA GGAGTATACTGCTTACAGGTTTAGATATAGTCTGTTAGAATTAAAACCAAGTTTAGTGTTCATATTTACCTCATGGGCTTTATCAAGCCC ATATTACCTCAGCTTATATATAGTTACCATTTTTAGGTTTTTAATTGTTTGACACTTGGATGATAAATGCAGTCATTTTATTCTCAAGTG CTTAAAATTAATGTAATTAAAAGCTTAGCTGACTACAGAATAGGTGAGGGTTTCTTAAAAATGAGATTTAAGGGCTGGGCACGGTGGCTC ATGCCTGTAATCCCAGCACTTTGGGAGGCCGAGGTGGGCGGATCACTTGAGGTTGGGAGTTCATGACCAGCTTGACCAACATGAAGAAAC CCTGTCTCTATTAAAAATACAAAAGTAGCCAGGCATGGTGGCGCATGCGTGTAATCCCAGCTACTTGGGAGGCTGAGGCAGGAGAATTGC TTGAACCTGGGAGGCAGAGGTTGCAGTGAGTCGAGATGGTGCCATTGCTCTCGTTTGGGCAACAAGAGTGAAACTCTTGTCTCAAAAAAA AAAAAAAATGAGGTTTAAGACAGTTTTGTCATTACTGGTGGGATCTGGTCACACAAGATAGCATTAAACGTGACATGGCACATAAAATTG GTTAAAAAATTTTGTTTTTTAATTACGTAATGTAAAAGCCCAACAAACACTTTATGCAAGATTGGAATGTATCTTCAAATTCAGATTTAA 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FusionGenePPI for PLEKHS1_PDCD4 |
| Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in . |
| Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160) |
| Hgene | Hgene's interactors | Tgene | Tgene's interactors |
| PLEKHS1 | GRB2, PIK3R3, PBLD | PDCD4 | EIF4A2, EIF4A1, RPL5, RPS13, EIF4G1, BTRC, FBXW11, EMD, ELAVL1, RPS6KA1, APOE, PSEN2, PSEN1, NAP1L1, NR1H2, VCP, CSNK2A1, DAXX, CD81, IGSF8, ARPC1B, BTF3, PAIP1, AAMP, TPD52, UFD1L, EIF4A3, TMEM51, COMTD1, RPS6KB2, HNRNPA1, UNK, EIF6, ETF1, NCAPD3, PCF11, EIF3H, EIF3I, PPP2R1B, PRMT5, PSMB6, THOC2, PSMC1, SNRPD1, NTRK1, UBE2S, HIST1H2BG, IBTK, CEP19, XPO1, TGIF2LY |
| - Retained PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
| - Lost PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
| - Retained PPIs, but lost function due to frame-shift fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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RelatedDrugs for PLEKHS1_PDCD4 |
| Drugs targeting genes involved in this fusion gene. (DrugBank Version 5.1.0 2018-04-02) |
| Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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RelatedDiseases for PLEKHS1_PDCD4 |
| Diseases associated with fusion partners. (DisGeNet 4.0) |
| Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
| Tgene | PDCD4 | C0027626 | Neoplasm Invasiveness | 1 | CTD_human |
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