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Fusion gene ID: 27654 |
FusionGeneSummary for PLEKHH2_THADA |
 Fusion gene summary |
| Fusion gene information | Fusion gene name: PLEKHH2_THADA | Fusion gene ID: 27654 | Hgene | Tgene | Gene symbol | PLEKHH2 | THADA | Gene ID | 130271 | 63892 |
| Gene name | pleckstrin homology, MyTH4 and FERM domain containing H2 | THADA, armadillo repeat containing | |
| Synonyms | PLEKHH1L | ARMC13|GITA | |
| Cytomap | 2p21 | 2p21 | |
| Type of gene | protein-coding | protein-coding | |
| Description | pleckstrin homology domain-containing family H member 2pleckstrin homology domain containing, family H (with MyTH4 domain) member 2 | thyroid adenoma-associated proteindeath receptor-interacting proteingene inducing thyroid adenomas protein | |
| Modification date | 20180519 | 20180523 | |
| UniProtAcc | Q8IVE3 | Q6YHU6 | |
| Ensembl transtripts involved in fusion gene | ENST00000282406, | ENST00000330266, ENST00000405975, ENST00000415080, ENST00000405006, ENST00000485353, ENST00000402360, ENST00000404790, ENST00000403856, | |
| Fusion gene scores | * DoF score | 3 X 2 X 3=18 | 9 X 9 X 7=567 |
| # samples | 3 | 10 | |
| ** MAII score | log2(3/18*10)=0.736965594166206 effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs). DoF>8 and MAII>0 | log2(10/567*10)=-2.5033487351675 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | |
| Context | PubMed: PLEKHH2 [Title/Abstract] AND THADA [Title/Abstract] AND fusion [Title/Abstract] | ||
| Functional or gene categories assigned by FusionGDB annotation | |||
| * DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
| Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Partner | Gene | GO ID | GO term | PubMed ID |
| Fusion gene information from three resources (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| TCGA | LD | CESC | TCGA-DS-A1O9-01A | PLEKHH2 | chr2 | 43871935 | + | THADA | chr2 | 43755127 | - |
| * LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
| Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| In-frame | ENST00000282406 | ENST00000330266 | PLEKHH2 | chr2 | 43871935 | + | THADA | chr2 | 43755127 | - |
| In-frame | ENST00000282406 | ENST00000405975 | PLEKHH2 | chr2 | 43871935 | + | THADA | chr2 | 43755127 | - |
| In-frame | ENST00000282406 | ENST00000415080 | PLEKHH2 | chr2 | 43871935 | + | THADA | chr2 | 43755127 | - |
| In-frame | ENST00000282406 | ENST00000405006 | PLEKHH2 | chr2 | 43871935 | + | THADA | chr2 | 43755127 | - |
| 5CDS-intron | ENST00000282406 | ENST00000485353 | PLEKHH2 | chr2 | 43871935 | + | THADA | chr2 | 43755127 | - |
| 5CDS-intron | ENST00000282406 | ENST00000402360 | PLEKHH2 | chr2 | 43871935 | + | THADA | chr2 | 43755127 | - |
| 5CDS-intron | ENST00000282406 | ENST00000404790 | PLEKHH2 | chr2 | 43871935 | + | THADA | chr2 | 43755127 | - |
| 5CDS-intron | ENST00000282406 | ENST00000403856 | PLEKHH2 | chr2 | 43871935 | + | THADA | chr2 | 43755127 | - |
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FusionProtFeatures for PLEKHH2_THADA |
| Main function of each fusion partner protein. (from UniProt) |
| Hgene | Tgene |
| PLEKHH2 | THADA |
| In the kidney glomerulus may play a role in linkingpodocyte foot processes to the glomerular basement membrane. Maybe involved in stabilization of F-actin by attenuating itsdepolymerization. Can recruit TGFB1I1 from focal adhesions topodocyte lamellipodia. |
| Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at . * Minus value of BPloci means that the break pointn is located before the CDS. |
| - In-frame and retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
| Tgene | >THADA | chr2:43871935 | chr2:43755127 | ENST00000402360 | - | 0 | 17 | 886_918 | -10 | 938 | Coiled coil | Ontology_term=ECO:0000255 |
| Tgene | >THADA | chr2:43871935 | chr2:43755127 | ENST00000402360 | - | 0 | 17 | 1322_1327 | -10 | 938 | Compositional bias | Note=Poly-Leu |
| Tgene | >THADA | chr2:43871935 | chr2:43755127 | ENST00000402360 | - | 0 | 17 | 1529_1532 | -10 | 938 | Compositional bias | Note=Poly-Ala |
| Tgene | >THADA | chr2:43871935 | chr2:43755127 | ENST00000402360 | - | 0 | 17 | 4_7 | -10 | 938 | Compositional bias | Note=Poly-Lys |
| Tgene | >THADA | chr2:43871935 | chr2:43755127 | ENST00000405006 | - | 20 | 38 | 1322_1327 | 1088 | 1954 | Compositional bias | Note=Poly-Leu |
| Tgene | >THADA | chr2:43871935 | chr2:43755127 | ENST00000405006 | - | 20 | 38 | 1529_1532 | 1088 | 1954 | Compositional bias | Note=Poly-Ala |
| Tgene | >THADA | chr2:43871935 | chr2:43755127 | ENST00000405975 | - | 20 | 38 | 1322_1327 | 1088 | 1954 | Compositional bias | Note=Poly-Leu |
| Tgene | >THADA | chr2:43871935 | chr2:43755127 | ENST00000405975 | - | 20 | 38 | 1529_1532 | 1088 | 1954 | Compositional bias | Note=Poly-Ala |
| - In-frame and not-retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
| Hgene | >PLEKHH2 | chr2:43871935 | chr2:43755127 | ENST00000282406 | + | 2 | 30 | 20_175 | 41 | 1494 | Coiled coil | Ontology_term=ECO:0000255 |
| Hgene | >PLEKHH2 | chr2:43871935 | chr2:43755127 | ENST00000282406 | + | 2 | 30 | 398_402 | 41 | 1494 | Compositional bias | Note=Poly-Ser |
| Hgene | >PLEKHH2 | chr2:43871935 | chr2:43755127 | ENST00000282406 | + | 2 | 30 | 613_666 | 41 | 1494 | Compositional bias | Note=Ser-rich |
| Hgene | >PLEKHH2 | chr2:43871935 | chr2:43755127 | ENST00000282406 | + | 2 | 30 | 693_696 | 41 | 1494 | Compositional bias | Note=Poly-Ser |
| Hgene | >PLEKHH2 | chr2:43871935 | chr2:43755127 | ENST00000282406 | + | 2 | 30 | 1121_1451 | 41 | 1494 | Domain | FERM |
| Hgene | >PLEKHH2 | chr2:43871935 | chr2:43755127 | ENST00000282406 | + | 2 | 30 | 703_797 | 41 | 1494 | Domain | PH 1 |
| Hgene | >PLEKHH2 | chr2:43871935 | chr2:43755127 | ENST00000282406 | + | 2 | 30 | 811_919 | 41 | 1494 | Domain | PH 2 |
| Hgene | >PLEKHH2 | chr2:43871935 | chr2:43755127 | ENST00000282406 | + | 2 | 30 | 955_1110 | 41 | 1494 | Domain | MyTH4 |
| Tgene | THADA | chr2:43871935 | chr2:43755127 | ENST00000405006 | - | 20 | 38 | 886_918 | 1088 | 1954 | Coiled coil | Ontology_term=ECO:0000255 |
| Tgene | THADA | chr2:43871935 | chr2:43755127 | ENST00000405975 | - | 20 | 38 | 886_918 | 1088 | 1954 | Coiled coil | Ontology_term=ECO:0000255 |
| Tgene | THADA | chr2:43871935 | chr2:43755127 | ENST00000405006 | - | 20 | 38 | 4_7 | 1088 | 1954 | Compositional bias | Note=Poly-Lys |
| Tgene | THADA | chr2:43871935 | chr2:43755127 | ENST00000405975 | - | 20 | 38 | 4_7 | 1088 | 1954 | Compositional bias | Note=Poly-Lys |
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FusionGeneSequence for PLEKHH2_THADA |
| For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. (nt: nucleotides, aa: amino acids) |
| * Fusion amino acid sequences. |
| >In-frame_PLEKHH2_ENST00000282406_chr2_43871935_+_THADA_ENST00000330266_chr2_43755127_-_341aa MAELSEPEGPVDWKERCVALESQLMKFRVQASKIRELLAEKVKEIGDYFKQHLLQSRHRGAFELAYTGFVKLTEVLNRCPNVSLQKLPEQ WLWSVLEEIKCSDPSSKLCATRRSAGIPFYIQALLASEPKKGRMDLLKITMKELISLAGPTDDIQSTVPQVHALNILRALFRDTRLGENI IPYVADGAKAAILGFTSPVWAVRNSSTLLFSALITRIFGVKRAKDEHSKTNRMTGREFFSRFPELYPFLLKQLETVANTVDSDMGEPNRH >In-frame_PLEKHH2_ENST00000282406_chr2_43871935_+_THADA_ENST00000405975_chr2_43755127_-_907aa MAELSEPEGPVDWKERCVALESQLMKFRVQASKIRELLAEKVKEIGDYFKQHLLQSRHRGAFELAYTGFVKLTEVLNRCPNVSLQKLPEQ WLWSVLEEIKCSDPSSKLCATRRSAGIPFYIQALLASEPKKGRMDLLKITMKELISLAGPTDDIQSTVPQVHALNILRALFRDTRLGENI IPYVADGAKAAILGFTSPVWAVRNSSTLLFSALITRIFGVKRAKDEHSKTNRMTGREFFSRFPELYPFLLKQLETVANTVDSDMGEPNRH PSMFLLLLVLERLYASPMDGTSSALSMGPFVPFIMRCGHSPVYHSREMAARALVPFVMIDHIPNTIRTLLSTLPSCTDQCFRQNHIHGTL LQVFHLLQAYSDSKHGTNSDFQHELTDITVCTKAKLWLAKRQNPCLVTRAVYIDILFLLTCCLNRSAKDNQPVLESLGFWEEVRGIISGS ELITGFPWAFKVPGLPQYLQSLTRLAIAAVWAAAAKSGERETNVPISFSQLLESAFPEVRSLTLEALLEKFLAAASGLGEKGVPPLLCNM GEKFLLLAMKENHPECFCKILKILHCMDPGEWLPQTEHCVHLTPKEFLIWTMDIASNERSEIQSVALRLASKVISHHMQTCVENRELIAA ELKQWVQLVILSCEDHLPTESRLAVVEVLTSTTPLFLTNPHPILELQDTLALWKCVLTLLQSEEQAVRDAATETVTTAMSQENTCQSTEF AFCQVDASIALALALAVLCDLLQQWDQLAPGLPILLGWLLGESDDLVACVESMHQVEEDYLFEKAEVNFWAETLIFVKYLCKHLFCLLSK SGWRPPSPEMLCHLQRMVSEQCHLLSQFFRELPPAAEFVKTVEFTRLRIQEERTLACLRLLAFLEGKEGEDTLVLSVWDSYAESRQLTLP >In-frame_PLEKHH2_ENST00000282406_chr2_43871935_+_THADA_ENST00000415080_chr2_43755127_-_878aa MAELSEPEGPVDWKERCVALESQLMKFRVQASKIRELLAEKVKEIGDYFKQHLLQSRHRGAFELAYTGFVKLTEVLNRCPNVSLQKLPEQ WLWSVLEEIKCSDPSSKLCATRRSAGIPFYIQALLASEPKKGRMDLLKITMKELISLAGPTDDIQSTVPQVHALNILRALFRDTRLGENI IPYVADGAKAAILGFTSPVWASQMTGREFFSRFPELYPFLLKQLETVANTVDSDMGEPNRHPSMFLLLLVLERLYASPMDGTSSALSMGP FVPFIMRCGHSPVYHSREMAARALVPFVMIDHIPNTIRTLLSTLPSCTDQCFRQNHIHGTLLQVFHLLQAYSDSKHGTNSDFQHELTDIT VCTKAKLWLAKRQNPCLVTRAVYIDILFLLTCCLNRSAKDNQPVLESLGFWEEVRGIISGSELITGFPWAFKVPGLPQYLQSLTRLAIAA VWAAAAKSGERETNVPISFSQLLESAFPEVRSLTLEALLEKFLAAASGLGEKGVPPLLCNMGEKFLLLAMKENHPECFCKILKILHCMDP GEWLPQTEHCVHLTPKEFLIWTMDIASNERSEIQSVALRLASKVISHHMQTCVENRELIAAELKQWVQLVILSCEDHLPTESRLAVVEVL TSTTPLFLTNPHPILELQDTLALWKCVLTLLQSEEQAVRDAATETVTTAMSQENTCQSTEFAFCQVDASIALALALAVLCDLLQQWDQLA PGLPILLGWLLGESDDLVACVESMHQVEEDYLFEKAEVNFWAETLIFVKYLCKHLFCLLSKSGWRPPSPEMLCHLQRMVSEQCHLLSQFF >In-frame_PLEKHH2_ENST00000282406_chr2_43871935_+_THADA_ENST00000405006_chr2_43755127_-_907aa MAELSEPEGPVDWKERCVALESQLMKFRVQASKIRELLAEKVKEIGDYFKQHLLQSRHRGAFELAYTGFVKLTEVLNRCPNVSLQKLPEQ WLWSVLEEIKCSDPSSKLCATRRSAGIPFYIQALLASEPKKGRMDLLKITMKELISLAGPTDDIQSTVPQVHALNILRALFRDTRLGENI IPYVADGAKAAILGFTSPVWAVRNSSTLLFSALITRIFGVKRAKDEHSKTNRMTGREFFSRFPELYPFLLKQLETVANTVDSDMGEPNRH PSMFLLLLVLERLYASPMDGTSSALSMGPFVPFIMRCGHSPVYHSREMAARALVPFVMIDHIPNTIRTLLSTLPSCTDQCFRQNHIHGTL LQVFHLLQAYSDSKHGTNSDFQHELTDITVCTKAKLWLAKRQNPCLVTRAVYIDILFLLTCCLNRSAKDNQPVLESLGFWEEVRGIISGS ELITGFPWAFKVPGLPQYLQSLTRLAIAAVWAAAAKSGERETNVPISFSQLLESAFPEVRSLTLEALLEKFLAAASGLGEKGVPPLLCNM GEKFLLLAMKENHPECFCKILKILHCMDPGEWLPQTEHCVHLTPKEFLIWTMDIASNERSEIQSVALRLASKVISHHMQTCVENRELIAA ELKQWVQLVILSCEDHLPTESRLAVVEVLTSTTPLFLTNPHPILELQDTLALWKCVLTLLQSEEQAVRDAATETVTTAMSQENTCQSTEF AFCQVDASIALALALAVLCDLLQQWDQLAPGLPILLGWLLGESDDLVACVESMHQVEEDYLFEKAEVNFWAETLIFVKYLCKHLFCLLSK SGWRPPSPEMLCHLQRMVSEQCHLLSQFFRELPPAAEFVKTVEFTRLRIQEERTLACLRLLAFLEGKEGEDTLVLSVWDSYAESRQLTLP |
| * Fusion transcript sequences (only coding sequence (CDS) region). |
| >In-frame_PLEKHH2_ENST00000282406_chr2_43871935_+_THADA_ENST00000330266_chr2_43755127_-_1023nt ATGGCAGAGCTTTCTGAGCCAGAGGGACCAGTAGATTGGAAGGAACGATGTGTAGCTCTGGAGTCCCAACTCATGAAATTTAGAGTTCAA GCAAGCAAGATACGAGAGCTTTTAGCAGAGAAGGTAAAAGAAATAGGAGATTACTTTAAACAACACCTTTTGCAGTCCAGGCACAGAGGA GCATTTGAATTGGCTTATACTGGTTTTGTGAAACTCACTGAAGTACTAAACAGGTGCCCAAATGTGAGTCTGCAAAAGCTGCCAGAACAG TGGCTATGGAGTGTTTTAGAGGAAATTAAATGCAGTGATCCTTCATCTAAACTCTGTGCTACAAGGCGCAGTGCTGGAATTCCTTTCTAC ATACAGGCACTGTTGGCATCTGAACCAAAGAAAGGCAGAATGGATTTGTTGAAAATAACAATGAAAGAGTTAATCTCTTTGGCTGGGCCT ACAGATGACATACAGAGTACAGTCCCCCAGGTTCATGCTTTAAATATCCTTAGAGCATTGTTCAGAGATACGCGCCTGGGAGAAAATATT ATTCCTTATGTTGCTGATGGAGCTAAGGCTGCAATTCTGGGTTTTACATCACCGGTCTGGGCAGTGCGAAATTCATCCACACTTCTCTTT AGTGCCTTGATCACAAGAATTTTTGGAGTTAAAAGGGCAAAGGATGAACATTCCAAAACAAATAGAATGACAGGGAGAGAGTTTTTCTCT CGTTTCCCAGAACTCTATCCTTTTCTTCTCAAACAGTTGGAAACTGTAGCCAATACAGTAGACAGTGATATGGGAGAACCAAATCGTCAT CCAAGCATGTTTCTCTTACTTTTGGTGTTGGAGAGACTCTACGCTTCCCCGATGGATGGTACTTCTTCTGCTCTCAGCATGGGACCTTTT GTTCCCTTCATTATGAGAGTCTTGCTCTGTTGTCCAGGCTGGAGTGCAGTGGCACGATCTCAGCTCACTGCAACCTCCACCTCCTGGGTT >In-frame_PLEKHH2_ENST00000282406_chr2_43871935_+_THADA_ENST00000405975_chr2_43755127_-_2721nt ATGGCAGAGCTTTCTGAGCCAGAGGGACCAGTAGATTGGAAGGAACGATGTGTAGCTCTGGAGTCCCAACTCATGAAATTTAGAGTTCAA GCAAGCAAGATACGAGAGCTTTTAGCAGAGAAGGTAAAAGAAATAGGAGATTACTTTAAACAACACCTTTTGCAGTCCAGGCACAGAGGA GCATTTGAATTGGCTTATACTGGTTTTGTGAAACTCACTGAAGTACTAAACAGGTGCCCAAATGTGAGTCTGCAAAAGCTGCCAGAACAG TGGCTATGGAGTGTTTTAGAGGAAATTAAATGCAGTGATCCTTCATCTAAACTCTGTGCTACAAGGCGCAGTGCTGGAATTCCTTTCTAC ATACAGGCACTGTTGGCATCTGAACCAAAGAAAGGCAGAATGGATTTGTTGAAAATAACAATGAAAGAGTTAATCTCTTTGGCTGGGCCT ACAGATGACATACAGAGTACAGTCCCCCAGGTTCATGCTTTAAATATCCTTAGAGCATTGTTCAGAGATACGCGCCTGGGAGAAAATATT ATTCCTTATGTTGCTGATGGAGCTAAGGCTGCAATTCTGGGTTTTACATCACCGGTCTGGGCAGTGCGAAATTCATCCACACTTCTCTTT AGTGCCTTGATCACAAGAATTTTTGGAGTTAAAAGGGCAAAGGATGAACATTCCAAAACAAATAGAATGACAGGGAGAGAGTTTTTCTCT CGTTTCCCAGAACTCTATCCTTTTCTTCTCAAACAGTTGGAAACTGTAGCCAATACAGTAGACAGTGATATGGGAGAACCAAATCGTCAT CCAAGCATGTTTCTCTTACTTTTGGTGTTGGAGAGACTCTACGCTTCCCCGATGGATGGTACTTCTTCTGCTCTCAGCATGGGACCTTTT GTTCCCTTCATTATGAGGTGTGGTCACTCACCTGTCTACCACTCCCGTGAAATGGCAGCTCGTGCCTTGGTCCCATTTGTTATGATAGAT CACATTCCTAATACCATTCGAACTCTGTTGTCCACACTCCCCAGCTGCACTGACCAGTGTTTCCGGCAAAACCACATTCATGGGACACTT CTCCAGGTTTTTCATTTGTTGCAAGCCTACTCAGACTCCAAACACGGAACGAATTCAGACTTCCAGCACGAGCTGACTGACATCACTGTT TGTACCAAAGCCAAACTCTGGCTGGCCAAGAGGCAAAATCCATGTTTGGTGACCAGAGCTGTATATATTGATATTCTCTTCCTATTGACT TGCTGCCTCAACAGATCTGCAAAGGACAACCAGCCAGTTCTGGAGAGTCTTGGCTTCTGGGAGGAAGTCAGAGGGATTATCTCAGGATCA GAGCTGATAACGGGATTCCCTTGGGCCTTCAAGGTGCCAGGCCTGCCCCAGTACCTCCAGAGCCTCACCAGACTAGCCATTGCTGCAGTG TGGGCCGCGGCAGCCAAGAGTGGAGAGCGGGAGACGAATGTCCCCATCTCTTTCTCTCAGCTGTTAGAATCTGCCTTCCCTGAAGTGCGC TCACTAACACTGGAAGCCCTCTTGGAAAAGTTCTTAGCAGCAGCCTCTGGACTTGGAGAGAAGGGCGTGCCACCCTTGCTGTGCAACATG GGAGAGAAGTTCTTATTGTTGGCCATGAAGGAAAATCACCCAGAATGCTTCTGCAAGATACTGAAAATTCTCCACTGCATGGACCCTGGT GAGTGGCTTCCCCAGACGGAGCACTGTGTCCATCTGACCCCAAAGGAGTTCTTGATCTGGACGATGGATATTGCTTCCAATGAAAGATCT GAAATTCAGAGTGTAGCTCTGAGACTTGCTTCCAAAGTCATTTCCCACCACATGCAGACATGTGTGGAGAACAGGGAATTGATAGCTGCT GAGCTGAAGCAGTGGGTTCAGCTGGTCATCTTGTCATGTGAAGACCATCTTCCTACAGAGTCTAGGCTGGCCGTCGTTGAAGTCCTCACC AGTACTACACCACTTTTCCTCACCAACCCCCATCCTATTCTTGAGTTGCAGGATACACTTGCTCTCTGGAAGTGTGTCCTTACCCTTCTG CAGAGTGAGGAGCAAGCTGTTAGAGATGCAGCCACGGAAACCGTGACAACTGCCATGTCACAAGAAAATACCTGCCAGTCAACAGAGTTT GCCTTCTGCCAGGTGGATGCCTCCATCGCTCTGGCCCTGGCCCTGGCCGTCCTGTGTGATCTGCTCCAGCAGTGGGACCAGTTGGCCCCT GGACTGCCCATCCTGCTGGGATGGCTGTTGGGAGAGAGTGATGACCTCGTGGCCTGTGTGGAGAGCATGCATCAGGTGGAAGAAGACTAC CTGTTTGAAAAAGCAGAAGTCAACTTTTGGGCCGAGACCCTGATCTTTGTGAAATACCTCTGCAAGCACCTCTTCTGTCTCCTCTCAAAG TCCGGCTGGCGTCCCCCAAGCCCTGAGATGCTCTGTCACCTTCAAAGGATGGTGTCAGAGCAGTGCCACCTCCTGTCTCAGTTCTTCAGA GAGCTTCCACCAGCTGCTGAGTTTGTGAAGACAGTGGAGTTCACAAGACTACGCATTCAAGAGGAAAGGACTTTGGCTTGCTTGAGGCTG CTGGCCTTTTTGGAAGGAAAGGAAGGGGAAGACACCCTAGTTCTCAGTGTTTGGGACTCTTATGCAGAATCGAGGCAGTTAACTCTTCCA >In-frame_PLEKHH2_ENST00000282406_chr2_43871935_+_THADA_ENST00000415080_chr2_43755127_-_2634nt ATGGCAGAGCTTTCTGAGCCAGAGGGACCAGTAGATTGGAAGGAACGATGTGTAGCTCTGGAGTCCCAACTCATGAAATTTAGAGTTCAA GCAAGCAAGATACGAGAGCTTTTAGCAGAGAAGGTAAAAGAAATAGGAGATTACTTTAAACAACACCTTTTGCAGTCCAGGCACAGAGGA GCATTTGAATTGGCTTATACTGGTTTTGTGAAACTCACTGAAGTACTAAACAGGTGCCCAAATGTGAGTCTGCAAAAGCTGCCAGAACAG TGGCTATGGAGTGTTTTAGAGGAAATTAAATGCAGTGATCCTTCATCTAAACTCTGTGCTACAAGGCGCAGTGCTGGAATTCCTTTCTAC ATACAGGCACTGTTGGCATCTGAACCAAAGAAAGGCAGAATGGATTTGTTGAAAATAACAATGAAAGAGTTAATCTCTTTGGCTGGGCCT ACAGATGACATACAGAGTACAGTCCCCCAGGTTCATGCTTTAAATATCCTTAGAGCATTGTTCAGAGATACGCGCCTGGGAGAAAATATT ATTCCTTATGTTGCTGATGGAGCTAAGGCTGCAATTCTGGGTTTTACATCACCGGTCTGGGCATCTCAAATGACAGGGAGAGAGTTTTTC TCTCGTTTCCCAGAACTCTATCCTTTTCTTCTCAAACAGTTGGAAACTGTAGCCAATACAGTAGACAGTGATATGGGAGAACCAAATCGT CATCCAAGCATGTTTCTCTTACTTTTGGTGTTGGAGAGACTCTACGCTTCCCCGATGGATGGTACTTCTTCTGCTCTCAGCATGGGACCT TTTGTTCCCTTCATTATGAGGTGTGGTCACTCACCTGTCTACCACTCCCGTGAAATGGCAGCTCGTGCCTTGGTCCCATTTGTTATGATA GATCACATTCCTAATACCATTCGAACTCTGTTGTCCACACTCCCCAGCTGCACTGACCAGTGTTTCCGGCAAAACCACATTCATGGGACA CTTCTCCAGGTTTTTCATTTGTTGCAAGCCTACTCAGACTCCAAACACGGAACGAATTCAGACTTCCAGCACGAGCTGACTGACATCACT GTTTGTACCAAAGCCAAACTCTGGCTGGCCAAGAGGCAAAATCCATGTTTGGTGACCAGAGCTGTATATATTGATATTCTCTTCCTATTG ACTTGCTGCCTCAACAGATCTGCAAAGGACAACCAGCCAGTTCTGGAGAGTCTTGGCTTCTGGGAGGAAGTCAGAGGGATTATCTCAGGA TCAGAGCTGATAACGGGATTCCCTTGGGCCTTCAAGGTGCCAGGCCTGCCCCAGTACCTCCAGAGCCTCACCAGACTAGCCATTGCTGCA GTGTGGGCCGCGGCAGCCAAGAGTGGAGAGCGGGAGACGAATGTCCCCATCTCTTTCTCTCAGCTGTTAGAATCTGCCTTCCCTGAAGTG CGCTCACTAACACTGGAAGCCCTCTTGGAAAAGTTCTTAGCAGCAGCCTCTGGACTTGGAGAGAAGGGCGTGCCACCCTTGCTGTGCAAC ATGGGAGAGAAGTTCTTATTGTTGGCCATGAAGGAAAATCACCCAGAATGCTTCTGCAAGATACTGAAAATTCTCCACTGCATGGACCCT GGTGAGTGGCTTCCCCAGACGGAGCACTGTGTCCATCTGACCCCAAAGGAGTTCTTGATCTGGACGATGGATATTGCTTCCAATGAAAGA TCTGAAATTCAGAGTGTAGCTCTGAGACTTGCTTCCAAAGTCATTTCCCACCACATGCAGACATGTGTGGAGAACAGGGAATTGATAGCT GCTGAGCTGAAGCAGTGGGTTCAGCTGGTCATCTTGTCATGTGAAGACCATCTTCCTACAGAGTCTAGGCTGGCCGTCGTTGAAGTCCTC ACCAGTACTACACCACTTTTCCTCACCAACCCCCATCCTATTCTTGAGTTGCAGGATACACTTGCTCTCTGGAAGTGTGTCCTTACCCTT CTGCAGAGTGAGGAGCAAGCTGTTAGAGATGCAGCCACGGAAACCGTGACAACTGCCATGTCACAAGAAAATACCTGCCAGTCAACAGAG TTTGCCTTCTGCCAGGTGGATGCCTCCATCGCTCTGGCCCTGGCCCTGGCCGTCCTGTGTGATCTGCTCCAGCAGTGGGACCAGTTGGCC CCTGGACTGCCCATCCTGCTGGGATGGCTGTTGGGAGAGAGTGATGACCTCGTGGCCTGTGTGGAGAGCATGCATCAGGTGGAAGAAGAC TACCTGTTTGAAAAAGCAGAAGTCAACTTTTGGGCCGAGACCCTGATCTTTGTGAAATACCTCTGCAAGCACCTCTTCTGTCTCCTCTCA AAGTCCGGCTGGCGTCCCCCAAGCCCTGAGATGCTCTGTCACCTTCAAAGGATGGTGTCAGAGCAGTGCCACCTCCTGTCTCAGTTCTTC AGAGAGCTTCCACCAGCTGCTGAGTTTGTGAAGACAGTGGAGTTCACAAGACTACGCATTCAAGAGGAAAGGACTTTGGCTTGCTTGAGG CTGCTGGCCTTTTTGGAAGGAAAGGAAGGGGAAGACACCCTAGTTCTCAGTGTTTGGGACTCTTATGCAGAATCGAGGCAGTTAACTCTT >In-frame_PLEKHH2_ENST00000282406_chr2_43871935_+_THADA_ENST00000405006_chr2_43755127_-_2721nt ATGGCAGAGCTTTCTGAGCCAGAGGGACCAGTAGATTGGAAGGAACGATGTGTAGCTCTGGAGTCCCAACTCATGAAATTTAGAGTTCAA GCAAGCAAGATACGAGAGCTTTTAGCAGAGAAGGTAAAAGAAATAGGAGATTACTTTAAACAACACCTTTTGCAGTCCAGGCACAGAGGA GCATTTGAATTGGCTTATACTGGTTTTGTGAAACTCACTGAAGTACTAAACAGGTGCCCAAATGTGAGTCTGCAAAAGCTGCCAGAACAG TGGCTATGGAGTGTTTTAGAGGAAATTAAATGCAGTGATCCTTCATCTAAACTCTGTGCTACAAGGCGCAGTGCTGGAATTCCTTTCTAC ATACAGGCACTGTTGGCATCTGAACCAAAGAAAGGCAGAATGGATTTGTTGAAAATAACAATGAAAGAGTTAATCTCTTTGGCTGGGCCT ACAGATGACATACAGAGTACAGTCCCCCAGGTTCATGCTTTAAATATCCTTAGAGCATTGTTCAGAGATACGCGCCTGGGAGAAAATATT ATTCCTTATGTTGCTGATGGAGCTAAGGCTGCAATTCTGGGTTTTACATCACCGGTCTGGGCAGTGCGAAATTCATCCACACTTCTCTTT AGTGCCTTGATCACAAGAATTTTTGGAGTTAAAAGGGCAAAGGATGAACATTCCAAAACAAATAGAATGACAGGGAGAGAGTTTTTCTCT CGTTTCCCAGAACTCTATCCTTTTCTTCTCAAACAGTTGGAAACTGTAGCCAATACAGTAGACAGTGATATGGGAGAACCAAATCGTCAT CCAAGCATGTTTCTCTTACTTTTGGTGTTGGAGAGACTCTACGCTTCCCCGATGGATGGTACTTCTTCTGCTCTCAGCATGGGACCTTTT GTTCCCTTCATTATGAGGTGTGGTCACTCACCTGTCTACCACTCCCGTGAAATGGCAGCTCGTGCCTTGGTCCCATTTGTTATGATAGAT CACATTCCTAATACCATTCGAACTCTGTTGTCCACACTCCCCAGCTGCACTGACCAGTGTTTCCGGCAAAACCACATTCATGGGACACTT CTCCAGGTTTTTCATTTGTTGCAAGCCTACTCAGACTCCAAACACGGAACGAATTCAGACTTCCAGCACGAGCTGACTGACATCACTGTT TGTACCAAAGCCAAACTCTGGCTGGCCAAGAGGCAAAATCCATGTTTGGTGACCAGAGCTGTATATATTGATATTCTCTTCCTATTGACT TGCTGCCTCAACAGATCTGCAAAGGACAACCAGCCAGTTCTGGAGAGTCTTGGCTTCTGGGAGGAAGTCAGAGGGATTATCTCAGGATCA GAGCTGATAACGGGATTCCCTTGGGCCTTCAAGGTGCCAGGCCTGCCCCAGTACCTCCAGAGCCTCACCAGACTAGCCATTGCTGCAGTG TGGGCCGCGGCAGCCAAGAGTGGAGAGCGGGAGACGAATGTCCCCATCTCTTTCTCTCAGCTGTTAGAATCTGCCTTCCCTGAAGTGCGC TCACTAACACTGGAAGCCCTCTTGGAAAAGTTCTTAGCAGCAGCCTCTGGACTTGGAGAGAAGGGCGTGCCACCCTTGCTGTGCAACATG GGAGAGAAGTTCTTATTGTTGGCCATGAAGGAAAATCACCCAGAATGCTTCTGCAAGATACTGAAAATTCTCCACTGCATGGACCCTGGT GAGTGGCTTCCCCAGACGGAGCACTGTGTCCATCTGACCCCAAAGGAGTTCTTGATCTGGACGATGGATATTGCTTCCAATGAAAGATCT GAAATTCAGAGTGTAGCTCTGAGACTTGCTTCCAAAGTCATTTCCCACCACATGCAGACATGTGTGGAGAACAGGGAATTGATAGCTGCT GAGCTGAAGCAGTGGGTTCAGCTGGTCATCTTGTCATGTGAAGACCATCTTCCTACAGAGTCTAGGCTGGCCGTCGTTGAAGTCCTCACC AGTACTACACCACTTTTCCTCACCAACCCCCATCCTATTCTTGAGTTGCAGGATACACTTGCTCTCTGGAAGTGTGTCCTTACCCTTCTG CAGAGTGAGGAGCAAGCTGTTAGAGATGCAGCCACGGAAACCGTGACAACTGCCATGTCACAAGAAAATACCTGCCAGTCAACAGAGTTT GCCTTCTGCCAGGTGGATGCCTCCATCGCTCTGGCCCTGGCCCTGGCCGTCCTGTGTGATCTGCTCCAGCAGTGGGACCAGTTGGCCCCT GGACTGCCCATCCTGCTGGGATGGCTGTTGGGAGAGAGTGATGACCTCGTGGCCTGTGTGGAGAGCATGCATCAGGTGGAAGAAGACTAC CTGTTTGAAAAAGCAGAAGTCAACTTTTGGGCCGAGACCCTGATCTTTGTGAAATACCTCTGCAAGCACCTCTTCTGTCTCCTCTCAAAG TCCGGCTGGCGTCCCCCAAGCCCTGAGATGCTCTGTCACCTTCAAAGGATGGTGTCAGAGCAGTGCCACCTCCTGTCTCAGTTCTTCAGA GAGCTTCCACCAGCTGCTGAGTTTGTGAAGACAGTGGAGTTCACAAGACTACGCATTCAAGAGGAAAGGACTTTGGCTTGCTTGAGGCTG CTGGCCTTTTTGGAAGGAAAGGAAGGGGAAGACACCCTAGTTCTCAGTGTTTGGGACTCTTATGCAGAATCGAGGCAGTTAACTCTTCCA |
| * Fusion transcript sequences (Full-length transcript). |
| >In-frame_PLEKHH2_ENST00000282406_chr2_43871935_+_THADA_ENST00000330266_chr2_43755127_-_1133nt GAGCTCGGCTTGAGGCGGGCGCGGGCTGAGAGTCCGGGGATCCCGGGGGCCAGTCGCGGCCGGGACATCGGGCGCTGCGGCCGGGGACCC GCTGCTGAGATAGACAGAATATGGCAGAGCTTTCTGAGCCAGAGGGACCAGTAGATTGGAAGGAACGATGTGTAGCTCTGGAGTCCCAAC TCATGAAATTTAGAGTTCAAGCAAGCAAGATACGAGAGCTTTTAGCAGAGAAGGTAAAAGAAATAGGAGATTACTTTAAACAACACCTTT TGCAGTCCAGGCACAGAGGAGCATTTGAATTGGCTTATACTGGTTTTGTGAAACTCACTGAAGTACTAAACAGGTGCCCAAATGTGAGTC TGCAAAAGCTGCCAGAACAGTGGCTATGGAGTGTTTTAGAGGAAATTAAATGCAGTGATCCTTCATCTAAACTCTGTGCTACAAGGCGCA GTGCTGGAATTCCTTTCTACATACAGGCACTGTTGGCATCTGAACCAAAGAAAGGCAGAATGGATTTGTTGAAAATAACAATGAAAGAGT TAATCTCTTTGGCTGGGCCTACAGATGACATACAGAGTACAGTCCCCCAGGTTCATGCTTTAAATATCCTTAGAGCATTGTTCAGAGATA CGCGCCTGGGAGAAAATATTATTCCTTATGTTGCTGATGGAGCTAAGGCTGCAATTCTGGGTTTTACATCACCGGTCTGGGCAGTGCGAA ATTCATCCACACTTCTCTTTAGTGCCTTGATCACAAGAATTTTTGGAGTTAAAAGGGCAAAGGATGAACATTCCAAAACAAATAGAATGA CAGGGAGAGAGTTTTTCTCTCGTTTCCCAGAACTCTATCCTTTTCTTCTCAAACAGTTGGAAACTGTAGCCAATACAGTAGACAGTGATA TGGGAGAACCAAATCGTCATCCAAGCATGTTTCTCTTACTTTTGGTGTTGGAGAGACTCTACGCTTCCCCGATGGATGGTACTTCTTCTG CTCTCAGCATGGGACCTTTTGTTCCCTTCATTATGAGAGTCTTGCTCTGTTGTCCAGGCTGGAGTGCAGTGGCACGATCTCAGCTCACTG >In-frame_PLEKHH2_ENST00000282406_chr2_43871935_+_THADA_ENST00000405975_chr2_43755127_-_2943nt GAGCTCGGCTTGAGGCGGGCGCGGGCTGAGAGTCCGGGGATCCCGGGGGCCAGTCGCGGCCGGGACATCGGGCGCTGCGGCCGGGGACCC GCTGCTGAGATAGACAGAATATGGCAGAGCTTTCTGAGCCAGAGGGACCAGTAGATTGGAAGGAACGATGTGTAGCTCTGGAGTCCCAAC TCATGAAATTTAGAGTTCAAGCAAGCAAGATACGAGAGCTTTTAGCAGAGAAGGTAAAAGAAATAGGAGATTACTTTAAACAACACCTTT TGCAGTCCAGGCACAGAGGAGCATTTGAATTGGCTTATACTGGTTTTGTGAAACTCACTGAAGTACTAAACAGGTGCCCAAATGTGAGTC TGCAAAAGCTGCCAGAACAGTGGCTATGGAGTGTTTTAGAGGAAATTAAATGCAGTGATCCTTCATCTAAACTCTGTGCTACAAGGCGCA GTGCTGGAATTCCTTTCTACATACAGGCACTGTTGGCATCTGAACCAAAGAAAGGCAGAATGGATTTGTTGAAAATAACAATGAAAGAGT TAATCTCTTTGGCTGGGCCTACAGATGACATACAGAGTACAGTCCCCCAGGTTCATGCTTTAAATATCCTTAGAGCATTGTTCAGAGATA CGCGCCTGGGAGAAAATATTATTCCTTATGTTGCTGATGGAGCTAAGGCTGCAATTCTGGGTTTTACATCACCGGTCTGGGCAGTGCGAA ATTCATCCACACTTCTCTTTAGTGCCTTGATCACAAGAATTTTTGGAGTTAAAAGGGCAAAGGATGAACATTCCAAAACAAATAGAATGA CAGGGAGAGAGTTTTTCTCTCGTTTCCCAGAACTCTATCCTTTTCTTCTCAAACAGTTGGAAACTGTAGCCAATACAGTAGACAGTGATA TGGGAGAACCAAATCGTCATCCAAGCATGTTTCTCTTACTTTTGGTGTTGGAGAGACTCTACGCTTCCCCGATGGATGGTACTTCTTCTG CTCTCAGCATGGGACCTTTTGTTCCCTTCATTATGAGGTGTGGTCACTCACCTGTCTACCACTCCCGTGAAATGGCAGCTCGTGCCTTGG TCCCATTTGTTATGATAGATCACATTCCTAATACCATTCGAACTCTGTTGTCCACACTCCCCAGCTGCACTGACCAGTGTTTCCGGCAAA ACCACATTCATGGGACACTTCTCCAGGTTTTTCATTTGTTGCAAGCCTACTCAGACTCCAAACACGGAACGAATTCAGACTTCCAGCACG AGCTGACTGACATCACTGTTTGTACCAAAGCCAAACTCTGGCTGGCCAAGAGGCAAAATCCATGTTTGGTGACCAGAGCTGTATATATTG ATATTCTCTTCCTATTGACTTGCTGCCTCAACAGATCTGCAAAGGACAACCAGCCAGTTCTGGAGAGTCTTGGCTTCTGGGAGGAAGTCA GAGGGATTATCTCAGGATCAGAGCTGATAACGGGATTCCCTTGGGCCTTCAAGGTGCCAGGCCTGCCCCAGTACCTCCAGAGCCTCACCA GACTAGCCATTGCTGCAGTGTGGGCCGCGGCAGCCAAGAGTGGAGAGCGGGAGACGAATGTCCCCATCTCTTTCTCTCAGCTGTTAGAAT CTGCCTTCCCTGAAGTGCGCTCACTAACACTGGAAGCCCTCTTGGAAAAGTTCTTAGCAGCAGCCTCTGGACTTGGAGAGAAGGGCGTGC CACCCTTGCTGTGCAACATGGGAGAGAAGTTCTTATTGTTGGCCATGAAGGAAAATCACCCAGAATGCTTCTGCAAGATACTGAAAATTC TCCACTGCATGGACCCTGGTGAGTGGCTTCCCCAGACGGAGCACTGTGTCCATCTGACCCCAAAGGAGTTCTTGATCTGGACGATGGATA TTGCTTCCAATGAAAGATCTGAAATTCAGAGTGTAGCTCTGAGACTTGCTTCCAAAGTCATTTCCCACCACATGCAGACATGTGTGGAGA ACAGGGAATTGATAGCTGCTGAGCTGAAGCAGTGGGTTCAGCTGGTCATCTTGTCATGTGAAGACCATCTTCCTACAGAGTCTAGGCTGG CCGTCGTTGAAGTCCTCACCAGTACTACACCACTTTTCCTCACCAACCCCCATCCTATTCTTGAGTTGCAGGATACACTTGCTCTCTGGA AGTGTGTCCTTACCCTTCTGCAGAGTGAGGAGCAAGCTGTTAGAGATGCAGCCACGGAAACCGTGACAACTGCCATGTCACAAGAAAATA CCTGCCAGTCAACAGAGTTTGCCTTCTGCCAGGTGGATGCCTCCATCGCTCTGGCCCTGGCCCTGGCCGTCCTGTGTGATCTGCTCCAGC AGTGGGACCAGTTGGCCCCTGGACTGCCCATCCTGCTGGGATGGCTGTTGGGAGAGAGTGATGACCTCGTGGCCTGTGTGGAGAGCATGC ATCAGGTGGAAGAAGACTACCTGTTTGAAAAAGCAGAAGTCAACTTTTGGGCCGAGACCCTGATCTTTGTGAAATACCTCTGCAAGCACC TCTTCTGTCTCCTCTCAAAGTCCGGCTGGCGTCCCCCAAGCCCTGAGATGCTCTGTCACCTTCAAAGGATGGTGTCAGAGCAGTGCCACC TCCTGTCTCAGTTCTTCAGAGAGCTTCCACCAGCTGCTGAGTTTGTGAAGACAGTGGAGTTCACAAGACTACGCATTCAAGAGGAAAGGA CTTTGGCTTGCTTGAGGCTGCTGGCCTTTTTGGAAGGAAAGGAAGGGGAAGACACCCTAGTTCTCAGTGTTTGGGACTCTTATGCAGAAT CGAGGCAGTTAACTCTTCCAAGAACAGAAGCGGCATGTTGAAGAAAATCTGGGGGATTGGGATGGGGGTATGTGTGGATTTTTCCTCCAC >In-frame_PLEKHH2_ENST00000282406_chr2_43871935_+_THADA_ENST00000415080_chr2_43755127_-_2855nt GAGCTCGGCTTGAGGCGGGCGCGGGCTGAGAGTCCGGGGATCCCGGGGGCCAGTCGCGGCCGGGACATCGGGCGCTGCGGCCGGGGACCC GCTGCTGAGATAGACAGAATATGGCAGAGCTTTCTGAGCCAGAGGGACCAGTAGATTGGAAGGAACGATGTGTAGCTCTGGAGTCCCAAC TCATGAAATTTAGAGTTCAAGCAAGCAAGATACGAGAGCTTTTAGCAGAGAAGGTAAAAGAAATAGGAGATTACTTTAAACAACACCTTT TGCAGTCCAGGCACAGAGGAGCATTTGAATTGGCTTATACTGGTTTTGTGAAACTCACTGAAGTACTAAACAGGTGCCCAAATGTGAGTC TGCAAAAGCTGCCAGAACAGTGGCTATGGAGTGTTTTAGAGGAAATTAAATGCAGTGATCCTTCATCTAAACTCTGTGCTACAAGGCGCA GTGCTGGAATTCCTTTCTACATACAGGCACTGTTGGCATCTGAACCAAAGAAAGGCAGAATGGATTTGTTGAAAATAACAATGAAAGAGT TAATCTCTTTGGCTGGGCCTACAGATGACATACAGAGTACAGTCCCCCAGGTTCATGCTTTAAATATCCTTAGAGCATTGTTCAGAGATA CGCGCCTGGGAGAAAATATTATTCCTTATGTTGCTGATGGAGCTAAGGCTGCAATTCTGGGTTTTACATCACCGGTCTGGGCATCTCAAA TGACAGGGAGAGAGTTTTTCTCTCGTTTCCCAGAACTCTATCCTTTTCTTCTCAAACAGTTGGAAACTGTAGCCAATACAGTAGACAGTG ATATGGGAGAACCAAATCGTCATCCAAGCATGTTTCTCTTACTTTTGGTGTTGGAGAGACTCTACGCTTCCCCGATGGATGGTACTTCTT CTGCTCTCAGCATGGGACCTTTTGTTCCCTTCATTATGAGGTGTGGTCACTCACCTGTCTACCACTCCCGTGAAATGGCAGCTCGTGCCT TGGTCCCATTTGTTATGATAGATCACATTCCTAATACCATTCGAACTCTGTTGTCCACACTCCCCAGCTGCACTGACCAGTGTTTCCGGC AAAACCACATTCATGGGACACTTCTCCAGGTTTTTCATTTGTTGCAAGCCTACTCAGACTCCAAACACGGAACGAATTCAGACTTCCAGC ACGAGCTGACTGACATCACTGTTTGTACCAAAGCCAAACTCTGGCTGGCCAAGAGGCAAAATCCATGTTTGGTGACCAGAGCTGTATATA TTGATATTCTCTTCCTATTGACTTGCTGCCTCAACAGATCTGCAAAGGACAACCAGCCAGTTCTGGAGAGTCTTGGCTTCTGGGAGGAAG TCAGAGGGATTATCTCAGGATCAGAGCTGATAACGGGATTCCCTTGGGCCTTCAAGGTGCCAGGCCTGCCCCAGTACCTCCAGAGCCTCA CCAGACTAGCCATTGCTGCAGTGTGGGCCGCGGCAGCCAAGAGTGGAGAGCGGGAGACGAATGTCCCCATCTCTTTCTCTCAGCTGTTAG AATCTGCCTTCCCTGAAGTGCGCTCACTAACACTGGAAGCCCTCTTGGAAAAGTTCTTAGCAGCAGCCTCTGGACTTGGAGAGAAGGGCG TGCCACCCTTGCTGTGCAACATGGGAGAGAAGTTCTTATTGTTGGCCATGAAGGAAAATCACCCAGAATGCTTCTGCAAGATACTGAAAA TTCTCCACTGCATGGACCCTGGTGAGTGGCTTCCCCAGACGGAGCACTGTGTCCATCTGACCCCAAAGGAGTTCTTGATCTGGACGATGG ATATTGCTTCCAATGAAAGATCTGAAATTCAGAGTGTAGCTCTGAGACTTGCTTCCAAAGTCATTTCCCACCACATGCAGACATGTGTGG AGAACAGGGAATTGATAGCTGCTGAGCTGAAGCAGTGGGTTCAGCTGGTCATCTTGTCATGTGAAGACCATCTTCCTACAGAGTCTAGGC TGGCCGTCGTTGAAGTCCTCACCAGTACTACACCACTTTTCCTCACCAACCCCCATCCTATTCTTGAGTTGCAGGATACACTTGCTCTCT GGAAGTGTGTCCTTACCCTTCTGCAGAGTGAGGAGCAAGCTGTTAGAGATGCAGCCACGGAAACCGTGACAACTGCCATGTCACAAGAAA ATACCTGCCAGTCAACAGAGTTTGCCTTCTGCCAGGTGGATGCCTCCATCGCTCTGGCCCTGGCCCTGGCCGTCCTGTGTGATCTGCTCC AGCAGTGGGACCAGTTGGCCCCTGGACTGCCCATCCTGCTGGGATGGCTGTTGGGAGAGAGTGATGACCTCGTGGCCTGTGTGGAGAGCA TGCATCAGGTGGAAGAAGACTACCTGTTTGAAAAAGCAGAAGTCAACTTTTGGGCCGAGACCCTGATCTTTGTGAAATACCTCTGCAAGC ACCTCTTCTGTCTCCTCTCAAAGTCCGGCTGGCGTCCCCCAAGCCCTGAGATGCTCTGTCACCTTCAAAGGATGGTGTCAGAGCAGTGCC ACCTCCTGTCTCAGTTCTTCAGAGAGCTTCCACCAGCTGCTGAGTTTGTGAAGACAGTGGAGTTCACAAGACTACGCATTCAAGAGGAAA GGACTTTGGCTTGCTTGAGGCTGCTGGCCTTTTTGGAAGGAAAGGAAGGGGAAGACACCCTAGTTCTCAGTGTTTGGGACTCTTATGCAG AATCGAGGCAGTTAACTCTTCCAAGAACAGAAGCGGCATGTTGAAGAAAATCTGGGGGATTGGGATGGGGGTATGTGTGGATTTTTCCTC >In-frame_PLEKHH2_ENST00000282406_chr2_43871935_+_THADA_ENST00000405006_chr2_43755127_-_2927nt GAGCTCGGCTTGAGGCGGGCGCGGGCTGAGAGTCCGGGGATCCCGGGGGCCAGTCGCGGCCGGGACATCGGGCGCTGCGGCCGGGGACCC GCTGCTGAGATAGACAGAATATGGCAGAGCTTTCTGAGCCAGAGGGACCAGTAGATTGGAAGGAACGATGTGTAGCTCTGGAGTCCCAAC TCATGAAATTTAGAGTTCAAGCAAGCAAGATACGAGAGCTTTTAGCAGAGAAGGTAAAAGAAATAGGAGATTACTTTAAACAACACCTTT TGCAGTCCAGGCACAGAGGAGCATTTGAATTGGCTTATACTGGTTTTGTGAAACTCACTGAAGTACTAAACAGGTGCCCAAATGTGAGTC TGCAAAAGCTGCCAGAACAGTGGCTATGGAGTGTTTTAGAGGAAATTAAATGCAGTGATCCTTCATCTAAACTCTGTGCTACAAGGCGCA GTGCTGGAATTCCTTTCTACATACAGGCACTGTTGGCATCTGAACCAAAGAAAGGCAGAATGGATTTGTTGAAAATAACAATGAAAGAGT TAATCTCTTTGGCTGGGCCTACAGATGACATACAGAGTACAGTCCCCCAGGTTCATGCTTTAAATATCCTTAGAGCATTGTTCAGAGATA CGCGCCTGGGAGAAAATATTATTCCTTATGTTGCTGATGGAGCTAAGGCTGCAATTCTGGGTTTTACATCACCGGTCTGGGCAGTGCGAA ATTCATCCACACTTCTCTTTAGTGCCTTGATCACAAGAATTTTTGGAGTTAAAAGGGCAAAGGATGAACATTCCAAAACAAATAGAATGA CAGGGAGAGAGTTTTTCTCTCGTTTCCCAGAACTCTATCCTTTTCTTCTCAAACAGTTGGAAACTGTAGCCAATACAGTAGACAGTGATA TGGGAGAACCAAATCGTCATCCAAGCATGTTTCTCTTACTTTTGGTGTTGGAGAGACTCTACGCTTCCCCGATGGATGGTACTTCTTCTG CTCTCAGCATGGGACCTTTTGTTCCCTTCATTATGAGGTGTGGTCACTCACCTGTCTACCACTCCCGTGAAATGGCAGCTCGTGCCTTGG TCCCATTTGTTATGATAGATCACATTCCTAATACCATTCGAACTCTGTTGTCCACACTCCCCAGCTGCACTGACCAGTGTTTCCGGCAAA ACCACATTCATGGGACACTTCTCCAGGTTTTTCATTTGTTGCAAGCCTACTCAGACTCCAAACACGGAACGAATTCAGACTTCCAGCACG AGCTGACTGACATCACTGTTTGTACCAAAGCCAAACTCTGGCTGGCCAAGAGGCAAAATCCATGTTTGGTGACCAGAGCTGTATATATTG ATATTCTCTTCCTATTGACTTGCTGCCTCAACAGATCTGCAAAGGACAACCAGCCAGTTCTGGAGAGTCTTGGCTTCTGGGAGGAAGTCA GAGGGATTATCTCAGGATCAGAGCTGATAACGGGATTCCCTTGGGCCTTCAAGGTGCCAGGCCTGCCCCAGTACCTCCAGAGCCTCACCA GACTAGCCATTGCTGCAGTGTGGGCCGCGGCAGCCAAGAGTGGAGAGCGGGAGACGAATGTCCCCATCTCTTTCTCTCAGCTGTTAGAAT CTGCCTTCCCTGAAGTGCGCTCACTAACACTGGAAGCCCTCTTGGAAAAGTTCTTAGCAGCAGCCTCTGGACTTGGAGAGAAGGGCGTGC CACCCTTGCTGTGCAACATGGGAGAGAAGTTCTTATTGTTGGCCATGAAGGAAAATCACCCAGAATGCTTCTGCAAGATACTGAAAATTC TCCACTGCATGGACCCTGGTGAGTGGCTTCCCCAGACGGAGCACTGTGTCCATCTGACCCCAAAGGAGTTCTTGATCTGGACGATGGATA TTGCTTCCAATGAAAGATCTGAAATTCAGAGTGTAGCTCTGAGACTTGCTTCCAAAGTCATTTCCCACCACATGCAGACATGTGTGGAGA ACAGGGAATTGATAGCTGCTGAGCTGAAGCAGTGGGTTCAGCTGGTCATCTTGTCATGTGAAGACCATCTTCCTACAGAGTCTAGGCTGG CCGTCGTTGAAGTCCTCACCAGTACTACACCACTTTTCCTCACCAACCCCCATCCTATTCTTGAGTTGCAGGATACACTTGCTCTCTGGA AGTGTGTCCTTACCCTTCTGCAGAGTGAGGAGCAAGCTGTTAGAGATGCAGCCACGGAAACCGTGACAACTGCCATGTCACAAGAAAATA CCTGCCAGTCAACAGAGTTTGCCTTCTGCCAGGTGGATGCCTCCATCGCTCTGGCCCTGGCCCTGGCCGTCCTGTGTGATCTGCTCCAGC AGTGGGACCAGTTGGCCCCTGGACTGCCCATCCTGCTGGGATGGCTGTTGGGAGAGAGTGATGACCTCGTGGCCTGTGTGGAGAGCATGC ATCAGGTGGAAGAAGACTACCTGTTTGAAAAAGCAGAAGTCAACTTTTGGGCCGAGACCCTGATCTTTGTGAAATACCTCTGCAAGCACC TCTTCTGTCTCCTCTCAAAGTCCGGCTGGCGTCCCCCAAGCCCTGAGATGCTCTGTCACCTTCAAAGGATGGTGTCAGAGCAGTGCCACC TCCTGTCTCAGTTCTTCAGAGAGCTTCCACCAGCTGCTGAGTTTGTGAAGACAGTGGAGTTCACAAGACTACGCATTCAAGAGGAAAGGA CTTTGGCTTGCTTGAGGCTGCTGGCCTTTTTGGAAGGAAAGGAAGGGGAAGACACCCTAGTTCTCAGTGTTTGGGACTCTTATGCAGAAT CGAGGCAGTTAACTCTTCCAAGAACAGAAGCGGCATGTTGAAGAAAATCTGGGGGATTGGGATGGGGGTATGTGTGGATTTTTCCTCCAC |
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FusionGenePPI for PLEKHH2_THADA |
| Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in . |
| Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160) |
| Hgene | Hgene's interactors | Tgene | Tgene's interactors |
| PLEKHH2 | LYN, LPXN, FBXW11 | THADA | CUL3, UBA2, AHCYL1, SRXN1, SSSCA1, SEC24A, SEC23A, SULT1A1, NUBP2, STAM, IGBP1, PSAT1, SIN3A, TES, EGFR, USHBP1, CD274, VSIG2, CA14, LYPD3, SCN2B, ALDH3A2, NTRK1, VASN, TMEM206, TNFRSF1A, OPRM1, SIGLECL1, CHRM4, FZD10, ILVBL, EDNRB, NAA10, CCKBR, CD83, APLNR, MLST8, MTOR, XPO6, XPO4 |
| - Retained PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
| - Lost PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
| - Retained PPIs, but lost function due to frame-shift fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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RelatedDrugs for PLEKHH2_THADA |
| Drugs targeting genes involved in this fusion gene. (DrugBank Version 5.1.0 2018-04-02) |
| Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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RelatedDiseases for PLEKHH2_THADA |
| Diseases associated with fusion partners. (DisGeNet 4.0) |
| Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
| Tgene | THADA | C0011860 | Diabetes Mellitus, Non-Insulin-Dependent | 1 | CTD_human |
Copyright 2018-Present -The University of Texas Health Science Center at Houston (UTHealth)
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