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Fusion gene ID: 27652 |
FusionGeneSummary for PLEKHH1_RAD51B |
 Fusion gene summary |
| Fusion gene information | Fusion gene name: PLEKHH1_RAD51B | Fusion gene ID: 27652 | Hgene | Tgene | Gene symbol | PLEKHH1 | RAD51B | Gene ID | 57475 | 5890 |
| Gene name | pleckstrin homology, MyTH4 and FERM domain containing H1 | RAD51 paralog B | |
| Synonyms | - | R51H2|RAD51L1|REC2 | |
| Cytomap | 14q24.1 | 14q24.1 | |
| Type of gene | protein-coding | protein-coding | |
| Description | pleckstrin homology domain-containing family H member 1PH domain-containing family H member 1pleckstrin homology domain containing, family H (with MyTH4 domain) member 1 | DNA repair protein RAD51 homolog 2RAD51 homolog BRecA-like proteinrecombination repair protein | |
| Modification date | 20180519 | 20180523 | |
| UniProtAcc | Q9ULM0 | O15315 | |
| Ensembl transtripts involved in fusion gene | ENST00000329153, ENST00000417684, ENST00000559832, | ENST00000487861, ENST00000471583, ENST00000487270, ENST00000488612, ENST00000390683, ENST00000469165, | |
| Fusion gene scores | * DoF score | 7 X 7 X 3=147 | 25 X 15 X 8=3000 |
| # samples | 8 | 33 | |
| ** MAII score | log2(8/147*10)=-0.877744249949002 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | log2(33/3000*10)=-3.18442457113743 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | |
| Context | PubMed: PLEKHH1 [Title/Abstract] AND RAD51B [Title/Abstract] AND fusion [Title/Abstract] | ||
| Functional or gene categories assigned by FusionGDB annotation | |||
| * DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
| Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Partner | Gene | GO ID | GO term | PubMed ID |
| Fusion gene information from three resources (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| TCGA | LD | STAD | TCGA-BR-8060-01A | PLEKHH1 | chr14 | 68026408 | + | RAD51B | chr14 | 68758601 | + |
| * LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
| Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| In-frame | ENST00000329153 | ENST00000487861 | PLEKHH1 | chr14 | 68026408 | + | RAD51B | chr14 | 68758601 | + |
| In-frame | ENST00000329153 | ENST00000471583 | PLEKHH1 | chr14 | 68026408 | + | RAD51B | chr14 | 68758601 | + |
| In-frame | ENST00000329153 | ENST00000487270 | PLEKHH1 | chr14 | 68026408 | + | RAD51B | chr14 | 68758601 | + |
| In-frame | ENST00000329153 | ENST00000488612 | PLEKHH1 | chr14 | 68026408 | + | RAD51B | chr14 | 68758601 | + |
| In-frame | ENST00000329153 | ENST00000390683 | PLEKHH1 | chr14 | 68026408 | + | RAD51B | chr14 | 68758601 | + |
| 5CDS-3UTR | ENST00000329153 | ENST00000469165 | PLEKHH1 | chr14 | 68026408 | + | RAD51B | chr14 | 68758601 | + |
| intron-3CDS | ENST00000417684 | ENST00000487861 | PLEKHH1 | chr14 | 68026408 | + | RAD51B | chr14 | 68758601 | + |
| intron-3CDS | ENST00000417684 | ENST00000471583 | PLEKHH1 | chr14 | 68026408 | + | RAD51B | chr14 | 68758601 | + |
| intron-3CDS | ENST00000417684 | ENST00000487270 | PLEKHH1 | chr14 | 68026408 | + | RAD51B | chr14 | 68758601 | + |
| intron-3CDS | ENST00000417684 | ENST00000488612 | PLEKHH1 | chr14 | 68026408 | + | RAD51B | chr14 | 68758601 | + |
| intron-3CDS | ENST00000417684 | ENST00000390683 | PLEKHH1 | chr14 | 68026408 | + | RAD51B | chr14 | 68758601 | + |
| intron-3UTR | ENST00000417684 | ENST00000469165 | PLEKHH1 | chr14 | 68026408 | + | RAD51B | chr14 | 68758601 | + |
| intron-3CDS | ENST00000559832 | ENST00000487861 | PLEKHH1 | chr14 | 68026408 | + | RAD51B | chr14 | 68758601 | + |
| intron-3CDS | ENST00000559832 | ENST00000471583 | PLEKHH1 | chr14 | 68026408 | + | RAD51B | chr14 | 68758601 | + |
| intron-3CDS | ENST00000559832 | ENST00000487270 | PLEKHH1 | chr14 | 68026408 | + | RAD51B | chr14 | 68758601 | + |
| intron-3CDS | ENST00000559832 | ENST00000488612 | PLEKHH1 | chr14 | 68026408 | + | RAD51B | chr14 | 68758601 | + |
| intron-3CDS | ENST00000559832 | ENST00000390683 | PLEKHH1 | chr14 | 68026408 | + | RAD51B | chr14 | 68758601 | + |
| intron-3UTR | ENST00000559832 | ENST00000469165 | PLEKHH1 | chr14 | 68026408 | + | RAD51B | chr14 | 68758601 | + |
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FusionProtFeatures for PLEKHH1_RAD51B |
| Main function of each fusion partner protein. (from UniProt) |
| Hgene | Tgene |
| PLEKHH1 | RAD51B |
| Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at . * Minus value of BPloci means that the break pointn is located before the CDS. |
| - In-frame and retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
| - In-frame and not-retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
| Hgene | >PLEKHH1 | chr14:68026408 | chr14:68758601 | ENST00000329153 | + | 5 | 29 | 28_169 | 141 | 1365 | Coiled coil | Ontology_term=ECO:0000255 |
| Hgene | >PLEKHH1 | chr14:68026408 | chr14:68758601 | ENST00000329153 | + | 5 | 29 | 239_242 | 141 | 1365 | Compositional bias | Note=Poly-Ser |
| Hgene | >PLEKHH1 | chr14:68026408 | chr14:68758601 | ENST00000329153 | + | 5 | 29 | 578_672 | 141 | 1365 | Domain | PH 1 |
| Hgene | >PLEKHH1 | chr14:68026408 | chr14:68758601 | ENST00000329153 | + | 5 | 29 | 687_796 | 141 | 1365 | Domain | PH 2 |
| Hgene | >PLEKHH1 | chr14:68026408 | chr14:68758601 | ENST00000329153 | + | 5 | 29 | 832_986 | 141 | 1365 | Domain | MyTH4 |
| Hgene | >PLEKHH1 | chr14:68026408 | chr14:68758601 | ENST00000329153 | + | 5 | 29 | 997_1333 | 141 | 1365 | Domain | FERM |
| Tgene | RAD51B | chr14:68026408 | chr14:68758601 | ENST00000390683 | + | 5 | 10 | 108_115 | 252 | 367 | Nucleotide binding | ATP |
| Tgene | RAD51B | chr14:68026408 | chr14:68758601 | ENST00000471583 | + | 6 | 11 | 108_115 | 252 | 351 | Nucleotide binding | ATP |
| Tgene | RAD51B | chr14:68026408 | chr14:68758601 | ENST00000487270 | + | 6 | 11 | 108_115 | 252 | 385 | Nucleotide binding | ATP |
| Tgene | RAD51B | chr14:68026408 | chr14:68758601 | ENST00000488612 | + | 6 | 12 | 108_115 | 252 | 495 | Nucleotide binding | ATP |
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FusionGeneSequence for PLEKHH1_RAD51B |
| For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. (nt: nucleotides, aa: amino acids) |
| * Fusion amino acid sequences. |
| >In-frame_PLEKHH1_ENST00000329153_chr14_68026408_+_RAD51B_ENST00000487861_chr14_68758601_+_315aa MAELKVEAPASVDWQKRCLTLETQLFRFRLQASKIRELLADKMQELEQRLLEAEQRAENAETQVGVMEEKVKLSNLKNVDSEGSLHRKYQ ELLKAIKGKDELISQLEAQLEKQKQMRAEEAKTVQEKAAKIKEWVTLKLAKVILTNQITTHLSGALASQADLVSPADDLSLSEGTSGSSC VIAALGNTWSHSVNTRLILQYLDSERRQILIAKSPLAPFTSFVYTIKEEGLVLQVVRTVARVSPRSECWSAADSHPSPTFLIPDVVLRKT >In-frame_PLEKHH1_ENST00000329153_chr14_68026408_+_RAD51B_ENST00000471583_chr14_68758601_+_240aa MAELKVEAPASVDWQKRCLTLETQLFRFRLQASKIRELLADKMQELEQRLLEAEQRAENAETQVGVMEEKVKLSNLKNVDSEGSLHRKYQ ELLKAIKGKDELISQLEAQLEKQKQMRAEEAKTVQEKAAKIKEWVTLKLAKVILTNQITTHLSGALASQADLVSPADDLSLSEGTSGSSC >In-frame_PLEKHH1_ENST00000329153_chr14_68026408_+_RAD51B_ENST00000487270_chr14_68758601_+_274aa MAELKVEAPASVDWQKRCLTLETQLFRFRLQASKIRELLADKMQELEQRLLEAEQRAENAETQVGVMEEKVKLSNLKNVDSEGSLHRKYQ ELLKAIKGKDELISQLEAQLEKQKQMRAEEAKTVQEKAAKIKEWVTLKLAKVILTNQITTHLSGALASQADLVSPADDLSLSEGTSGSSC VIAALGNTWSHSVNTRLILQYLDSERRQILIAKSPLAPFTSFVYTIKEEGLVLQETTFCSVTQAELNWAPEILPPQPPEQLGLQMCHHTQ >In-frame_PLEKHH1_ENST00000329153_chr14_68026408_+_RAD51B_ENST00000488612_chr14_68758601_+_256aa MAELKVEAPASVDWQKRCLTLETQLFRFRLQASKIRELLADKMQELEQRLLEAEQRAENAETQVGVMEEKVKLSNLKNVDSEGSLHRKYQ ELLKAIKGKDELISQLEAQLEKQKQMRAEEAKTVQEKAAKIKEWVTLKLAKVILTNQITTHLSGALASQADLVSPADDLSLSEGTSGSSC >In-frame_PLEKHH1_ENST00000329153_chr14_68026408_+_RAD51B_ENST00000390683_chr14_68758601_+_256aa MAELKVEAPASVDWQKRCLTLETQLFRFRLQASKIRELLADKMQELEQRLLEAEQRAENAETQVGVMEEKVKLSNLKNVDSEGSLHRKYQ ELLKAIKGKDELISQLEAQLEKQKQMRAEEAKTVQEKAAKIKEWVTLKLAKVILTNQITTHLSGALASQADLVSPADDLSLSEGTSGSSC |
| * Fusion transcript sequences (only coding sequence (CDS) region). |
| >In-frame_PLEKHH1_ENST00000329153_chr14_68026408_+_RAD51B_ENST00000487861_chr14_68758601_+_945nt ATGGCAGAACTCAAGGTGGAGGCGCCGGCCAGCGTAGACTGGCAGAAACGCTGCCTGACCCTGGAAACTCAGCTTTTCCGGTTCCGCCTA CAGGCCAGCAAGATAAGGGAGCTGCTGGCTGACAAGATGCAGGAGCTGGAGCAGAGGCTGCTGGAGGCAGAGCAGAGAGCAGAGAACGCT GAGACCCAGGTGGGTGTCATGGAAGAGAAGGTAAAACTATCCAATCTGAAGAATGTGGACTCTGAGGGGAGCCTGCACCGGAAATACCAA GAATTGCTGAAAGCCATAAAGGGCAAAGATGAGCTCATCAGCCAGCTAGAGGCTCAGCTGGAGAAGCAGAAGCAGATGAGGGCAGAGGAA GCAAAAACTGTTCAAGAAAAAGCTGCAAAGATCAAGGAATGGGTGACACTCAAGTTGGCAAAGGTTATCTTGACGAATCAGATTACAACC CATCTGAGTGGAGCCCTGGCTTCTCAGGCAGACCTGGTGTCTCCAGCTGATGATTTGTCCCTGTCTGAAGGCACTTCTGGATCCAGCTGT GTGATAGCCGCACTAGGAAATACCTGGAGTCACAGTGTGAATACCCGGCTGATCCTCCAGTACCTTGATTCAGAGAGAAGACAGATTCTT ATTGCCAAGTCCCCTCTGGCTCCCTTCACCTCATTTGTCTACACCATCAAGGAGGAAGGCCTGGTTCTTCAAGTTGTTAGAACTGTGGCC AGAGTCAGCCCCAGGTCAGAATGCTGGTCAGCAGCAGACTCACATCCCAGCCCTACCTTCCTGATACCTGATGTGGTGCTCAGAAAAACA AGGAATCCCAGGCTGTTACCCAGTGTCTCCATGTGCCCTCCACAGATGCACTCAACTGTCCTCTCTTCTGCTCTTCCTCCTACAAACTGG >In-frame_PLEKHH1_ENST00000329153_chr14_68026408_+_RAD51B_ENST00000471583_chr14_68758601_+_720nt ATGGCAGAACTCAAGGTGGAGGCGCCGGCCAGCGTAGACTGGCAGAAACGCTGCCTGACCCTGGAAACTCAGCTTTTCCGGTTCCGCCTA CAGGCCAGCAAGATAAGGGAGCTGCTGGCTGACAAGATGCAGGAGCTGGAGCAGAGGCTGCTGGAGGCAGAGCAGAGAGCAGAGAACGCT GAGACCCAGGTGGGTGTCATGGAAGAGAAGGTAAAACTATCCAATCTGAAGAATGTGGACTCTGAGGGGAGCCTGCACCGGAAATACCAA GAATTGCTGAAAGCCATAAAGGGCAAAGATGAGCTCATCAGCCAGCTAGAGGCTCAGCTGGAGAAGCAGAAGCAGATGAGGGCAGAGGAA GCAAAAACTGTTCAAGAAAAAGCTGCAAAGATCAAGGAATGGGTGACACTCAAGTTGGCAAAGGTTATCTTGACGAATCAGATTACAACC CATCTGAGTGGAGCCCTGGCTTCTCAGGCAGACCTGGTGTCTCCAGCTGATGATTTGTCCCTGTCTGAAGGCACTTCTGGATCCAGCTGT GTGATAGCCGCACTAGGAAATACCTGGAGTCACAGTGTGAATACCCGGCTGATCCTCCAGTACCTTGATTCAGAGAGAAGACAGATTCTT ATTGCCAAGTCCCCTCTGGCTCCCTTCACCTCATTTGTCTACACCATCAAGGAGGAAGGCCTGGTTCTTCAAGGCCAAGAGAAGCCATAG >In-frame_PLEKHH1_ENST00000329153_chr14_68026408_+_RAD51B_ENST00000487270_chr14_68758601_+_822nt ATGGCAGAACTCAAGGTGGAGGCGCCGGCCAGCGTAGACTGGCAGAAACGCTGCCTGACCCTGGAAACTCAGCTTTTCCGGTTCCGCCTA CAGGCCAGCAAGATAAGGGAGCTGCTGGCTGACAAGATGCAGGAGCTGGAGCAGAGGCTGCTGGAGGCAGAGCAGAGAGCAGAGAACGCT GAGACCCAGGTGGGTGTCATGGAAGAGAAGGTAAAACTATCCAATCTGAAGAATGTGGACTCTGAGGGGAGCCTGCACCGGAAATACCAA GAATTGCTGAAAGCCATAAAGGGCAAAGATGAGCTCATCAGCCAGCTAGAGGCTCAGCTGGAGAAGCAGAAGCAGATGAGGGCAGAGGAA GCAAAAACTGTTCAAGAAAAAGCTGCAAAGATCAAGGAATGGGTGACACTCAAGTTGGCAAAGGTTATCTTGACGAATCAGATTACAACC CATCTGAGTGGAGCCCTGGCTTCTCAGGCAGACCTGGTGTCTCCAGCTGATGATTTGTCCCTGTCTGAAGGCACTTCTGGATCCAGCTGT GTGATAGCCGCACTAGGAAATACCTGGAGTCACAGTGTGAATACCCGGCTGATCCTCCAGTACCTTGATTCAGAGAGAAGACAGATTCTT ATTGCCAAGTCCCCTCTGGCTCCCTTCACCTCATTTGTCTACACCATCAAGGAGGAAGGCCTGGTTCTTCAAGAGACAACATTTTGCTCT GTCACCCAAGCTGAACTGAACTGGGCTCCAGAAATCCTCCCACCTCAGCCTCCTGAGCAGCTAGGACTACAGATGTGCCACCATACCCAG >In-frame_PLEKHH1_ENST00000329153_chr14_68026408_+_RAD51B_ENST00000488612_chr14_68758601_+_768nt ATGGCAGAACTCAAGGTGGAGGCGCCGGCCAGCGTAGACTGGCAGAAACGCTGCCTGACCCTGGAAACTCAGCTTTTCCGGTTCCGCCTA CAGGCCAGCAAGATAAGGGAGCTGCTGGCTGACAAGATGCAGGAGCTGGAGCAGAGGCTGCTGGAGGCAGAGCAGAGAGCAGAGAACGCT GAGACCCAGGTGGGTGTCATGGAAGAGAAGGTAAAACTATCCAATCTGAAGAATGTGGACTCTGAGGGGAGCCTGCACCGGAAATACCAA GAATTGCTGAAAGCCATAAAGGGCAAAGATGAGCTCATCAGCCAGCTAGAGGCTCAGCTGGAGAAGCAGAAGCAGATGAGGGCAGAGGAA GCAAAAACTGTTCAAGAAAAAGCTGCAAAGATCAAGGAATGGGTGACACTCAAGTTGGCAAAGGTTATCTTGACGAATCAGATTACAACC CATCTGAGTGGAGCCCTGGCTTCTCAGGCAGACCTGGTGTCTCCAGCTGATGATTTGTCCCTGTCTGAAGGCACTTCTGGATCCAGCTGT GTGATAGCCGCACTAGGAAATACCTGGAGTCACAGTGTGAATACCCGGCTGATCCTCCAGTACCTTGATTCAGAGAGAAGACAGATTCTT ATTGCCAAGTCCCCTCTGGCTCCCTTCACCTCATTTGTCTACACCATCAAGGAGGAAGGCCTGGTTCTTCAAGAATTTTGGCACATTTGC >In-frame_PLEKHH1_ENST00000329153_chr14_68026408_+_RAD51B_ENST00000390683_chr14_68758601_+_768nt ATGGCAGAACTCAAGGTGGAGGCGCCGGCCAGCGTAGACTGGCAGAAACGCTGCCTGACCCTGGAAACTCAGCTTTTCCGGTTCCGCCTA CAGGCCAGCAAGATAAGGGAGCTGCTGGCTGACAAGATGCAGGAGCTGGAGCAGAGGCTGCTGGAGGCAGAGCAGAGAGCAGAGAACGCT GAGACCCAGGTGGGTGTCATGGAAGAGAAGGTAAAACTATCCAATCTGAAGAATGTGGACTCTGAGGGGAGCCTGCACCGGAAATACCAA GAATTGCTGAAAGCCATAAAGGGCAAAGATGAGCTCATCAGCCAGCTAGAGGCTCAGCTGGAGAAGCAGAAGCAGATGAGGGCAGAGGAA GCAAAAACTGTTCAAGAAAAAGCTGCAAAGATCAAGGAATGGGTGACACTCAAGTTGGCAAAGGTTATCTTGACGAATCAGATTACAACC CATCTGAGTGGAGCCCTGGCTTCTCAGGCAGACCTGGTGTCTCCAGCTGATGATTTGTCCCTGTCTGAAGGCACTTCTGGATCCAGCTGT GTGATAGCCGCACTAGGAAATACCTGGAGTCACAGTGTGAATACCCGGCTGATCCTCCAGTACCTTGATTCAGAGAGAAGACAGATTCTT ATTGCCAAGTCCCCTCTGGCTCCCTTCACCTCATTTGTCTACACCATCAAGGAGGAAGGCCTGGTTCTTCAAGAATTTTGGCACATTTGC |
| * Fusion transcript sequences (Full-length transcript). |
| >In-frame_PLEKHH1_ENST00000329153_chr14_68026408_+_RAD51B_ENST00000487861_chr14_68758601_+_1395nt GGGACTCCGGCGAGAGCGACGCAAGGTCGGCTGCGGCGGCGGCCCGAGGGCGCCCGTGTGCCCAGTGCGCGGCGGGGACGGCCGCGAGCT CGCTGGAGGGCTCCCCAGAATAATCCAGAAGTCGATTCCATCATGGCAGAACTCAAGGTGGAGGCGCCGGCCAGCGTAGACTGGCAGAAA CGCTGCCTGACCCTGGAAACTCAGCTTTTCCGGTTCCGCCTACAGGCCAGCAAGATAAGGGAGCTGCTGGCTGACAAGATGCAGGAGCTG GAGCAGAGGCTGCTGGAGGCAGAGCAGAGAGCAGAGAACGCTGAGACCCAGGTGGGTGTCATGGAAGAGAAGGTAAAACTATCCAATCTG AAGAATGTGGACTCTGAGGGGAGCCTGCACCGGAAATACCAAGAATTGCTGAAAGCCATAAAGGGCAAAGATGAGCTCATCAGCCAGCTA GAGGCTCAGCTGGAGAAGCAGAAGCAGATGAGGGCAGAGGAAGCAAAAACTGTTCAAGAAAAAGCTGCAAAGATCAAGGAATGGGTGACA CTCAAGTTGGCAAAGGTTATCTTGACGAATCAGATTACAACCCATCTGAGTGGAGCCCTGGCTTCTCAGGCAGACCTGGTGTCTCCAGCT GATGATTTGTCCCTGTCTGAAGGCACTTCTGGATCCAGCTGTGTGATAGCCGCACTAGGAAATACCTGGAGTCACAGTGTGAATACCCGG CTGATCCTCCAGTACCTTGATTCAGAGAGAAGACAGATTCTTATTGCCAAGTCCCCTCTGGCTCCCTTCACCTCATTTGTCTACACCATC AAGGAGGAAGGCCTGGTTCTTCAAGTTGTTAGAACTGTGGCCAGAGTCAGCCCCAGGTCAGAATGCTGGTCAGCAGCAGACTCACATCCC AGCCCTACCTTCCTGATACCTGATGTGGTGCTCAGAAAAACAAGGAATCCCAGGCTGTTACCCAGTGTCTCCATGTGCCCTCCACAGATG CACTCAACTGTCCTCTCTTCTGCTCTTCCTCCTACAAACTGGGCAACTGGAATCAGAACAGAGACTTTGGATGAGCATCCAGTGTAACCC AGCCTAGTTTTTCACCACGACTTCCAGATCTACATTTAACATCCGACAGCAACTATAATTCTACTTTCTGAACCTCCAGGGAAGTTGCTT CCTTGTCCCTTTCAGCAAAGGATGTCATGGTTTTACAATGTCTCCAGTGAAAAAGTTCTTCTTCTCTACATCTTCCTCCCACTCCTACAA CCCTTGATCCCCACGTGAGATCTCATTTCCTCCAGCTGGGTCTTCTGCAGAGTGATTAGAGCTTCTGCCCTCCTTGCAGCATCTCTATTG >In-frame_PLEKHH1_ENST00000329153_chr14_68026408_+_RAD51B_ENST00000471583_chr14_68758601_+_1287nt GGGACTCCGGCGAGAGCGACGCAAGGTCGGCTGCGGCGGCGGCCCGAGGGCGCCCGTGTGCCCAGTGCGCGGCGGGGACGGCCGCGAGCT CGCTGGAGGGCTCCCCAGAATAATCCAGAAGTCGATTCCATCATGGCAGAACTCAAGGTGGAGGCGCCGGCCAGCGTAGACTGGCAGAAA CGCTGCCTGACCCTGGAAACTCAGCTTTTCCGGTTCCGCCTACAGGCCAGCAAGATAAGGGAGCTGCTGGCTGACAAGATGCAGGAGCTG GAGCAGAGGCTGCTGGAGGCAGAGCAGAGAGCAGAGAACGCTGAGACCCAGGTGGGTGTCATGGAAGAGAAGGTAAAACTATCCAATCTG AAGAATGTGGACTCTGAGGGGAGCCTGCACCGGAAATACCAAGAATTGCTGAAAGCCATAAAGGGCAAAGATGAGCTCATCAGCCAGCTA GAGGCTCAGCTGGAGAAGCAGAAGCAGATGAGGGCAGAGGAAGCAAAAACTGTTCAAGAAAAAGCTGCAAAGATCAAGGAATGGGTGACA CTCAAGTTGGCAAAGGTTATCTTGACGAATCAGATTACAACCCATCTGAGTGGAGCCCTGGCTTCTCAGGCAGACCTGGTGTCTCCAGCT GATGATTTGTCCCTGTCTGAAGGCACTTCTGGATCCAGCTGTGTGATAGCCGCACTAGGAAATACCTGGAGTCACAGTGTGAATACCCGG CTGATCCTCCAGTACCTTGATTCAGAGAGAAGACAGATTCTTATTGCCAAGTCCCCTCTGGCTCCCTTCACCTCATTTGTCTACACCATC AAGGAGGAAGGCCTGGTTCTTCAAGGCCAAGAGAAGCCATAGGGATACTGTGACCTTTGTCTAGAGTTGATGGGGGTGTGATTTGTGAAA TAAAACAGGACCGTACTGCTTGGAAGAAGGAAACGGAAGCTGACATAATGGGGATTAATTAGTTGATTGCTGTTGAGATGGTAACAGATT TGCTCCTAAACCATTGAGCTAGCGATTTCAGACCTAGCAGGGAAGGTGAAGATGAAGAAGCCTTTGTTCAGGTCTCTAGATGTGTAGGGC TGAGGGCTTTGCCGCCATGGGATGTCAACAGCCATAATAATAATTTGCACTTATATAGCACCTTTCAACCAGGCACCTCAAAGCGGTTTA ACCACATTAATTAATTAAAGCCCACAATCCTCCTGGGGAGAGGAGGAGGATGACTAACAAGATTTGTAATTACAGGAGGGAACATTTCCG >In-frame_PLEKHH1_ENST00000329153_chr14_68026408_+_RAD51B_ENST00000487270_chr14_68758601_+_2347nt GGGACTCCGGCGAGAGCGACGCAAGGTCGGCTGCGGCGGCGGCCCGAGGGCGCCCGTGTGCCCAGTGCGCGGCGGGGACGGCCGCGAGCT CGCTGGAGGGCTCCCCAGAATAATCCAGAAGTCGATTCCATCATGGCAGAACTCAAGGTGGAGGCGCCGGCCAGCGTAGACTGGCAGAAA CGCTGCCTGACCCTGGAAACTCAGCTTTTCCGGTTCCGCCTACAGGCCAGCAAGATAAGGGAGCTGCTGGCTGACAAGATGCAGGAGCTG GAGCAGAGGCTGCTGGAGGCAGAGCAGAGAGCAGAGAACGCTGAGACCCAGGTGGGTGTCATGGAAGAGAAGGTAAAACTATCCAATCTG AAGAATGTGGACTCTGAGGGGAGCCTGCACCGGAAATACCAAGAATTGCTGAAAGCCATAAAGGGCAAAGATGAGCTCATCAGCCAGCTA GAGGCTCAGCTGGAGAAGCAGAAGCAGATGAGGGCAGAGGAAGCAAAAACTGTTCAAGAAAAAGCTGCAAAGATCAAGGAATGGGTGACA CTCAAGTTGGCAAAGGTTATCTTGACGAATCAGATTACAACCCATCTGAGTGGAGCCCTGGCTTCTCAGGCAGACCTGGTGTCTCCAGCT GATGATTTGTCCCTGTCTGAAGGCACTTCTGGATCCAGCTGTGTGATAGCCGCACTAGGAAATACCTGGAGTCACAGTGTGAATACCCGG CTGATCCTCCAGTACCTTGATTCAGAGAGAAGACAGATTCTTATTGCCAAGTCCCCTCTGGCTCCCTTCACCTCATTTGTCTACACCATC AAGGAGGAAGGCCTGGTTCTTCAAGAGACAACATTTTGCTCTGTCACCCAAGCTGAACTGAACTGGGCTCCAGAAATCCTCCCACCTCAG CCTCCTGAGCAGCTAGGACTACAGATGTGCCACCATACCCAGCTAATTTTTTAATTTTTTGTAGAGGTGGGGTCTCATTATGTTGCCCAA GCTGATCTCAAACTCCTGGCTTCAAGAGATCCACCCACCTCAGCCTCCCAAAGCGCTAGGATTACAAGTATGAGACTTTGCCATTCCAAT GAGAATTTTGTCCTTAGCAATCTCATCCAATGGCCACTGGAGATGTGTGTAGGGCCACAAGAATGAGAAAGGGGGCAATGGAGTGACAGG TGACCTGCTCAGGTGCCCCTCCCCAGACCAAATGTCCCAGGCACACAGCCCATGCCCTCCACCATGGAGTACATTTTCTCCCTGGCTTGC TGCTGAGCTAAAGGACCAGGGACGTGGAAACAGGAGGTGAACTAAGGCACCCCGCCACCCACTGTGGCAGCTTGAATTTCTTGAGGCTGA GACAAACTAGGATCCAGTAGCCTAGATTTTGCCCCAGTTTCTCCACTGAGTATTTACTCAGTGCTCCTGAGCCGATGCCTTCCCCTCTGC CTAGATGAACCACAGCATTTTGGTAAATGCCTCAGCATGTTAGGAGCGCTGGAACGTTTATTCTCTTCCCTCCCAATTATCCACTCTAAT GGAGCAGAACACTTACATGGAAAATCCTAAACATGGAAGATGATTTAAAAATGATTCACCCTGGAATACATGCTTCCAGTTGCTTCTACA GGTTTACCTTGCTAAAGGCATTTCGCTTCCTTTGCTGTTACAATAAGCTTGCCTGCCTTGAAGAAAAGAAGACCAGGGCCAAAGGGAAAT CAGTCAAGGGAGCCTGTTTTGTCTGAAATAATGCATCCATGAACAAATGAATTGAGTATAACTGTCTTTTTACATCAGTGTTTCTGTGGA ATTAAGAGAACATCCAAGGCCACTCCTAGCTTGAGTAGATTAAATTTGTCCTTGTGTTTGGAGCAAGGGTTGTGAAGTCTGTCTGGCCCA TCAAATGACCAATGGCTTTTAAGGAAGGACTAAGTGACTTATGACCAGAACAAGGGAGCAGCCTGAGTCAGTCTCCCCAATGTCTACATT GTGTTATTTATACTAGCAAAAAAATAGACACAACTAAATGTTCGACCATATGGTATTGGTTAAATTAACATCTATACGATGGAATACTAG ATGGTCATTAAAATTATGTGTCAGAAGAAGGCTTAATCTCATGGGAAAGTGTTCACACCATATTATTAAAGAGAAAAAACAGATTATAAA GCAATATGCATACAATGTAGTAGTTCTGTAAGAAAAAAGTATTATGTGCATTTTAACTGGAAAAATATGTATAAAAATGTTAACAGTGCA ATCTCTGGGCAATAAGATTATACTTGACTTTTATTTCTTTTTTGGAATTGTCTTTTTTTTTTTTTTTTCAAGTTTCCTCCCATTAACATG >In-frame_PLEKHH1_ENST00000329153_chr14_68026408_+_RAD51B_ENST00000488612_chr14_68758601_+_1322nt GGGACTCCGGCGAGAGCGACGCAAGGTCGGCTGCGGCGGCGGCCCGAGGGCGCCCGTGTGCCCAGTGCGCGGCGGGGACGGCCGCGAGCT CGCTGGAGGGCTCCCCAGAATAATCCAGAAGTCGATTCCATCATGGCAGAACTCAAGGTGGAGGCGCCGGCCAGCGTAGACTGGCAGAAA CGCTGCCTGACCCTGGAAACTCAGCTTTTCCGGTTCCGCCTACAGGCCAGCAAGATAAGGGAGCTGCTGGCTGACAAGATGCAGGAGCTG GAGCAGAGGCTGCTGGAGGCAGAGCAGAGAGCAGAGAACGCTGAGACCCAGGTGGGTGTCATGGAAGAGAAGGTAAAACTATCCAATCTG AAGAATGTGGACTCTGAGGGGAGCCTGCACCGGAAATACCAAGAATTGCTGAAAGCCATAAAGGGCAAAGATGAGCTCATCAGCCAGCTA GAGGCTCAGCTGGAGAAGCAGAAGCAGATGAGGGCAGAGGAAGCAAAAACTGTTCAAGAAAAAGCTGCAAAGATCAAGGAATGGGTGACA CTCAAGTTGGCAAAGGTTATCTTGACGAATCAGATTACAACCCATCTGAGTGGAGCCCTGGCTTCTCAGGCAGACCTGGTGTCTCCAGCT GATGATTTGTCCCTGTCTGAAGGCACTTCTGGATCCAGCTGTGTGATAGCCGCACTAGGAAATACCTGGAGTCACAGTGTGAATACCCGG CTGATCCTCCAGTACCTTGATTCAGAGAGAAGACAGATTCTTATTGCCAAGTCCCCTCTGGCTCCCTTCACCTCATTTGTCTACACCATC AAGGAGGAAGGCCTGGTTCTTCAAGAATTTTGGCACATTTGCATATCTGGTTTCTCAATCCAGAACAGACTAAAAGAAAATGAGTCCTGA GATTGCTACAGATGAGACCCACCCATCGGAGCCAGGCTTTGAAGGAACTGACCGCAGTGTGCATGAGGAAGTACTTCACGGTGATGACCC TCGCCACCCTCTCAGGAAAACACAGTGACCTCTCCCCCAACATCCCCTTCCCACTCCCAGGTCCCCCGGCAAAGGCAGAAGAACCAAGCA AGCCTTTCCACCAAAGCAGCCATGAACCCCATTCTCATCCTTTCCAAGAACTCTCTGCTATACCAGATAGGGGTTTGGGGTTCTGTTTTC CATTTTTTAAAAAAATCATTTCAAGACTCTTGAACAGTGTGTCGGTTTACACTATTCTATCTTCTTAAGCCACCATATCAACATATTCAC >In-frame_PLEKHH1_ENST00000329153_chr14_68026408_+_RAD51B_ENST00000390683_chr14_68758601_+_900nt GGGACTCCGGCGAGAGCGACGCAAGGTCGGCTGCGGCGGCGGCCCGAGGGCGCCCGTGTGCCCAGTGCGCGGCGGGGACGGCCGCGAGCT CGCTGGAGGGCTCCCCAGAATAATCCAGAAGTCGATTCCATCATGGCAGAACTCAAGGTGGAGGCGCCGGCCAGCGTAGACTGGCAGAAA CGCTGCCTGACCCTGGAAACTCAGCTTTTCCGGTTCCGCCTACAGGCCAGCAAGATAAGGGAGCTGCTGGCTGACAAGATGCAGGAGCTG GAGCAGAGGCTGCTGGAGGCAGAGCAGAGAGCAGAGAACGCTGAGACCCAGGTGGGTGTCATGGAAGAGAAGGTAAAACTATCCAATCTG AAGAATGTGGACTCTGAGGGGAGCCTGCACCGGAAATACCAAGAATTGCTGAAAGCCATAAAGGGCAAAGATGAGCTCATCAGCCAGCTA GAGGCTCAGCTGGAGAAGCAGAAGCAGATGAGGGCAGAGGAAGCAAAAACTGTTCAAGAAAAAGCTGCAAAGATCAAGGAATGGGTGACA CTCAAGTTGGCAAAGGTTATCTTGACGAATCAGATTACAACCCATCTGAGTGGAGCCCTGGCTTCTCAGGCAGACCTGGTGTCTCCAGCT GATGATTTGTCCCTGTCTGAAGGCACTTCTGGATCCAGCTGTGTGATAGCCGCACTAGGAAATACCTGGAGTCACAGTGTGAATACCCGG CTGATCCTCCAGTACCTTGATTCAGAGAGAAGACAGATTCTTATTGCCAAGTCCCCTCTGGCTCCCTTCACCTCATTTGTCTACACCATC AAGGAGGAAGGCCTGGTTCTTCAAGAATTTTGGCACATTTGCATATCTGGTTTCTCAATCCAGAACAGACTAAAAGAAAATGAGTCCTGA |
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FusionGenePPI for PLEKHH1_RAD51B |
| Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in . |
| Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160) |
| Hgene | Hgene's interactors | Tgene | Tgene's interactors |
| PLEKHH1 | APBB1IP, LPXN | RAD51B | RAD51, RAD51C, RAD51D, XRCC2, SWSAP1, FAM9B, DKKL1, ARL4C, MUC20, ADAMTS4, HELQ |
| - Retained PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
| - Lost PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
| Tgene | RAD51B | chr14:68026408 | chr14:68758601 | ENST00000390683 | + | 5 | 10 | 1_75 | 252 | 367 | RAD51C |
| Tgene | RAD51B | chr14:68026408 | chr14:68758601 | ENST00000471583 | + | 6 | 11 | 1_75 | 252 | 351 | RAD51C |
| Tgene | RAD51B | chr14:68026408 | chr14:68758601 | ENST00000487270 | + | 6 | 11 | 1_75 | 252 | 385 | RAD51C |
| Tgene | RAD51B | chr14:68026408 | chr14:68758601 | ENST00000488612 | + | 6 | 12 | 1_75 | 252 | 495 | RAD51C |
| - Retained PPIs, but lost function due to frame-shift fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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RelatedDrugs for PLEKHH1_RAD51B |
| Drugs targeting genes involved in this fusion gene. (DrugBank Version 5.1.0 2018-04-02) |
| Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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RelatedDiseases for PLEKHH1_RAD51B |
| Diseases associated with fusion partners. (DisGeNet 4.0) |
| Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
| Hgene | PLEKHH1 | C0023893 | Liver Cirrhosis, Experimental | 1 | CTD_human |
| Tgene | RAD51B | C0236969 | Substance-Related Disorders | 1 | CTD_human |
| Tgene | RAD51B | C0242788 | Breast Neoplasms, Male | 1 | CTD_human |
| Tgene | RAD51B | C1458155 | Mammary Neoplasms | 1 | CTD_human |
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