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Fusion gene ID: 27650 |
FusionGeneSummary for PLEKHH1_MPP5 |
 Fusion gene summary |
| Fusion gene information | Fusion gene name: PLEKHH1_MPP5 | Fusion gene ID: 27650 | Hgene | Tgene | Gene symbol | PLEKHH1 | MPP5 | Gene ID | 57475 | 64398 |
| Gene name | pleckstrin homology, MyTH4 and FERM domain containing H1 | membrane palmitoylated protein 5 | |
| Synonyms | - | PALS1 | |
| Cytomap | 14q24.1 | 14q23.3 | |
| Type of gene | protein-coding | protein-coding | |
| Description | pleckstrin homology domain-containing family H member 1PH domain-containing family H member 1pleckstrin homology domain containing, family H (with MyTH4 domain) member 1 | MAGUK p55 subfamily member 5membrane protein, palmitoylated 5 (MAGUK p55 subfamily member 5)protein associated with Lin-7 1protein associated with lin seven 1stardust | |
| Modification date | 20180519 | 20180519 | |
| UniProtAcc | Q9ULM0 | Q8N3R9 | |
| Ensembl transtripts involved in fusion gene | ENST00000329153, ENST00000417684, ENST00000559832, | ENST00000261681, ENST00000555925, ENST00000554911, ENST00000556345, | |
| Fusion gene scores | * DoF score | 7 X 7 X 3=147 | 3 X 3 X 4=36 |
| # samples | 8 | 4 | |
| ** MAII score | log2(8/147*10)=-0.877744249949002 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | log2(4/36*10)=0.15200309344505 effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs). DoF>8 and MAII>0 | |
| Context | PubMed: PLEKHH1 [Title/Abstract] AND MPP5 [Title/Abstract] AND fusion [Title/Abstract] | ||
| Functional or gene categories assigned by FusionGDB annotation | Kinase involved fusion gene, inframe and retained kinase domain. | ||
| * DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
| Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Partner | Gene | GO ID | GO term | PubMed ID |
| Fusion gene information from three resources (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| TCGA | RV | BLCA | TCGA-2F-A9KW-01A | PLEKHH1 | chr14 | 68035933 | + | MPP5 | chr14 | 67759228 | + |
| TCGA | RV | STAD | TCGA-BR-8373-01A | PLEKHH1 | chr14 | 68008710 | + | MPP5 | chr14 | 67759228 | + |
| * LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
| Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| In-frame | ENST00000329153 | ENST00000261681 | PLEKHH1 | chr14 | 68035933 | + | MPP5 | chr14 | 67759228 | + |
| In-frame | ENST00000329153 | ENST00000555925 | PLEKHH1 | chr14 | 68035933 | + | MPP5 | chr14 | 67759228 | + |
| 5CDS-intron | ENST00000329153 | ENST00000554911 | PLEKHH1 | chr14 | 68035933 | + | MPP5 | chr14 | 67759228 | + |
| 5CDS-intron | ENST00000329153 | ENST00000556345 | PLEKHH1 | chr14 | 68035933 | + | MPP5 | chr14 | 67759228 | + |
| intron-3CDS | ENST00000417684 | ENST00000261681 | PLEKHH1 | chr14 | 68035933 | + | MPP5 | chr14 | 67759228 | + |
| intron-3CDS | ENST00000417684 | ENST00000555925 | PLEKHH1 | chr14 | 68035933 | + | MPP5 | chr14 | 67759228 | + |
| intron-intron | ENST00000417684 | ENST00000554911 | PLEKHH1 | chr14 | 68035933 | + | MPP5 | chr14 | 67759228 | + |
| intron-intron | ENST00000417684 | ENST00000556345 | PLEKHH1 | chr14 | 68035933 | + | MPP5 | chr14 | 67759228 | + |
| intron-3CDS | ENST00000559832 | ENST00000261681 | PLEKHH1 | chr14 | 68035933 | + | MPP5 | chr14 | 67759228 | + |
| intron-3CDS | ENST00000559832 | ENST00000555925 | PLEKHH1 | chr14 | 68035933 | + | MPP5 | chr14 | 67759228 | + |
| intron-intron | ENST00000559832 | ENST00000554911 | PLEKHH1 | chr14 | 68035933 | + | MPP5 | chr14 | 67759228 | + |
| intron-intron | ENST00000559832 | ENST00000556345 | PLEKHH1 | chr14 | 68035933 | + | MPP5 | chr14 | 67759228 | + |
| Frame-shift | ENST00000329153 | ENST00000261681 | PLEKHH1 | chr14 | 68008710 | + | MPP5 | chr14 | 67759228 | + |
| Frame-shift | ENST00000329153 | ENST00000555925 | PLEKHH1 | chr14 | 68008710 | + | MPP5 | chr14 | 67759228 | + |
| 5CDS-intron | ENST00000329153 | ENST00000554911 | PLEKHH1 | chr14 | 68008710 | + | MPP5 | chr14 | 67759228 | + |
| 5CDS-intron | ENST00000329153 | ENST00000556345 | PLEKHH1 | chr14 | 68008710 | + | MPP5 | chr14 | 67759228 | + |
| intron-3CDS | ENST00000417684 | ENST00000261681 | PLEKHH1 | chr14 | 68008710 | + | MPP5 | chr14 | 67759228 | + |
| intron-3CDS | ENST00000417684 | ENST00000555925 | PLEKHH1 | chr14 | 68008710 | + | MPP5 | chr14 | 67759228 | + |
| intron-intron | ENST00000417684 | ENST00000554911 | PLEKHH1 | chr14 | 68008710 | + | MPP5 | chr14 | 67759228 | + |
| intron-intron | ENST00000417684 | ENST00000556345 | PLEKHH1 | chr14 | 68008710 | + | MPP5 | chr14 | 67759228 | + |
| intron-3CDS | ENST00000559832 | ENST00000261681 | PLEKHH1 | chr14 | 68008710 | + | MPP5 | chr14 | 67759228 | + |
| intron-3CDS | ENST00000559832 | ENST00000555925 | PLEKHH1 | chr14 | 68008710 | + | MPP5 | chr14 | 67759228 | + |
| intron-intron | ENST00000559832 | ENST00000554911 | PLEKHH1 | chr14 | 68008710 | + | MPP5 | chr14 | 67759228 | + |
| intron-intron | ENST00000559832 | ENST00000556345 | PLEKHH1 | chr14 | 68008710 | + | MPP5 | chr14 | 67759228 | + |
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FusionProtFeatures for PLEKHH1_MPP5 |
| Main function of each fusion partner protein. (from UniProt) |
| Hgene | Tgene |
| PLEKHH1 | MPP5 |
| May play a role in tight junctions biogenesis and in theestablishment of cell polarity in epithelial cells. May modulateSC6A1/GAT1-mediated GABA uptake by stabilizing the transporter.Required for localization of EZR to the apical membrane ofparietal cells and may play a role in the dynamic remodeling ofthe apical cytoskeleton (By similarity). {ECO:0000250}. |
| Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at . * Minus value of BPloci means that the break pointn is located before the CDS. |
| - In-frame and retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
| Hgene | PLEKHH1 | chr14:68035933 | chr14:67759228 | ENST00000329153 | + | 8 | 29 | 28_169 | 447 | 1365 | Coiled coil | Ontology_term=ECO:0000255 |
| Hgene | PLEKHH1 | chr14:68035933 | chr14:67759228 | ENST00000329153 | + | 8 | 29 | 239_242 | 447 | 1365 | Compositional bias | Note=Poly-Ser |
| Tgene | >MPP5 | chr14:68035933 | chr14:67759228 | ENST00000261681 | + | 2 | 15 | 120_177 | 122 | 676 | Domain | L27 1 |
| Tgene | >MPP5 | chr14:68035933 | chr14:67759228 | ENST00000261681 | + | 2 | 15 | 179_235 | 122 | 676 | Domain | L27 2 |
| Tgene | >MPP5 | chr14:68035933 | chr14:67759228 | ENST00000261681 | + | 2 | 15 | 256_336 | 122 | 676 | Domain | PDZ |
| Tgene | >MPP5 | chr14:68035933 | chr14:67759228 | ENST00000261681 | + | 2 | 15 | 345_417 | 122 | 676 | Domain | SH3 |
| Tgene | >MPP5 | chr14:68035933 | chr14:67759228 | ENST00000261681 | + | 2 | 15 | 479_660 | 122 | 676 | Domain | Guanylate kinase-like |
| Tgene | >MPP5 | chr14:68035933 | chr14:67759228 | ENST00000555925 | + | 2 | 15 | 120_177 | 88 | 642 | Domain | L27 1 |
| Tgene | >MPP5 | chr14:68035933 | chr14:67759228 | ENST00000555925 | + | 2 | 15 | 179_235 | 88 | 642 | Domain | L27 2 |
| Tgene | >MPP5 | chr14:68035933 | chr14:67759228 | ENST00000555925 | + | 2 | 15 | 256_336 | 88 | 642 | Domain | PDZ |
| Tgene | >MPP5 | chr14:68035933 | chr14:67759228 | ENST00000555925 | + | 2 | 15 | 345_417 | 88 | 642 | Domain | SH3 |
| Tgene | >MPP5 | chr14:68035933 | chr14:67759228 | ENST00000555925 | + | 2 | 15 | 479_660 | 88 | 642 | Domain | Guanylate kinase-like |
| - In-frame and not-retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
| Hgene | >PLEKHH1 | chr14:68035933 | chr14:67759228 | ENST00000329153 | + | 8 | 29 | 578_672 | 447 | 1365 | Domain | PH 1 |
| Hgene | >PLEKHH1 | chr14:68035933 | chr14:67759228 | ENST00000329153 | + | 8 | 29 | 687_796 | 447 | 1365 | Domain | PH 2 |
| Hgene | >PLEKHH1 | chr14:68035933 | chr14:67759228 | ENST00000329153 | + | 8 | 29 | 832_986 | 447 | 1365 | Domain | MyTH4 |
| Hgene | >PLEKHH1 | chr14:68035933 | chr14:67759228 | ENST00000329153 | + | 8 | 29 | 997_1333 | 447 | 1365 | Domain | FERM |
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FusionGeneSequence for PLEKHH1_MPP5 |
| For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. (nt: nucleotides, aa: amino acids) |
| * Fusion amino acid sequences. |
| >In-frame_PLEKHH1_ENST00000329153_chr14_68035933_+_MPP5_ENST00000261681_chr14_67759228_+_1001aa MAELKVEAPASVDWQKRCLTLETQLFRFRLQASKIRELLADKMQELEQRLLEAEQRAENAETQVGVMEEKVKLSNLKNVDSEGSLHRKYQ ELLKAIKGKDELISQLEAQLEKQKQMRAEEAKTVQEKAAKIKEWVTLKLAKLEMENQHLKSHNQRLVEQVGSLQDALEAIQIAPSRKLLV PPYGAAEQDSVPSEPGIQPMGQDSGSQAQGLKAAVLAPSPGALQSKDSVSEAASPLEDSSSSTVHSGETVEAKPLQPHLGRESPPHQPCM KLLTFRCSSASWGEGLVTAQRGMLPGTKTSAREGGPGSSLTLPKVRAPGTPRDSIQLAKRHHSQPQVGHGHFGRVVNIETEAFSALHPSG LPELESRARSREEPEKMEMEEPPPAGKNEERESPKALGAELEEVELGNKPPTPPLHQFSSWESRIYAVATSGMRLSDMSPRSNTACCEIE DLFSSLKHIQHTLVDSQSQEDISLLLQLVQNKDFQNAFKIHNAITVHMNKASPPFPLISNAQDLAQEVQTVLKPVHHKEGQELTALLNTP HIQALLLAHDKVAEQEMQLEPITDERVYESIGQYGGETVKIVRIEKARDIPLGATVRNEMDSVIISRIVKGGAAEKSGLLHEGDEVLEIN GIEIRGKDVNEVFDLLSDMHGTLTFVLIPSQQIKPPPAKETVIHVKAHFDYDPSDDPYVPCRELGLSFQKGDILHVISQEDPNWWQAYRE GDEDNQPLAGLVPGKSFQQQREAMKQTIEEDKEPEKSGKLWCAKKNKKKRKKVLYNANKNDDYDNEEILTYEEMSLYHQPANRKRPIILI GPQNCGQNELRQRLMNKEKDRFASAVPHTTRSRRDQEVAGRDYHFVSRQAFEADIAAGKFIEHGEFEKNLYGTSIDSVRQVINSGKICLL SLRTQSLKTLRNSDLKPYIIFIAPPSQERLRALLAKEGKNPKPEELREIIEKTREMEQNNGHYFDTAIVNSDLDKAYQELLRLINKLDTE >In-frame_PLEKHH1_ENST00000329153_chr14_68035933_+_MPP5_ENST00000555925_chr14_67759228_+_1001aa MAELKVEAPASVDWQKRCLTLETQLFRFRLQASKIRELLADKMQELEQRLLEAEQRAENAETQVGVMEEKVKLSNLKNVDSEGSLHRKYQ ELLKAIKGKDELISQLEAQLEKQKQMRAEEAKTVQEKAAKIKEWVTLKLAKLEMENQHLKSHNQRLVEQVGSLQDALEAIQIAPSRKLLV PPYGAAEQDSVPSEPGIQPMGQDSGSQAQGLKAAVLAPSPGALQSKDSVSEAASPLEDSSSSTVHSGETVEAKPLQPHLGRESPPHQPCM KLLTFRCSSASWGEGLVTAQRGMLPGTKTSAREGGPGSSLTLPKVRAPGTPRDSIQLAKRHHSQPQVGHGHFGRVVNIETEAFSALHPSG LPELESRARSREEPEKMEMEEPPPAGKNEERESPKALGAELEEVELGNKPPTPPLHQFSSWESRIYAVATSGMRLSDMSPRSNTACCEIE DLFSSLKHIQHTLVDSQSQEDISLLLQLVQNKDFQNAFKIHNAITVHMNKASPPFPLISNAQDLAQEVQTVLKPVHHKEGQELTALLNTP HIQALLLAHDKVAEQEMQLEPITDERVYESIGQYGGETVKIVRIEKARDIPLGATVRNEMDSVIISRIVKGGAAEKSGLLHEGDEVLEIN GIEIRGKDVNEVFDLLSDMHGTLTFVLIPSQQIKPPPAKETVIHVKAHFDYDPSDDPYVPCRELGLSFQKGDILHVISQEDPNWWQAYRE GDEDNQPLAGLVPGKSFQQQREAMKQTIEEDKEPEKSGKLWCAKKNKKKRKKVLYNANKNDDYDNEEILTYEEMSLYHQPANRKRPIILI GPQNCGQNELRQRLMNKEKDRFASAVPHTTRSRRDQEVAGRDYHFVSRQAFEADIAAGKFIEHGEFEKNLYGTSIDSVRQVINSGKICLL SLRTQSLKTLRNSDLKPYIIFIAPPSQERLRALLAKEGKNPKPEELREIIEKTREMEQNNGHYFDTAIVNSDLDKAYQELLRLINKLDTE |
| * Fusion transcript sequences (only coding sequence (CDS) region). |
| >In-frame_PLEKHH1_ENST00000329153_chr14_68035933_+_MPP5_ENST00000261681_chr14_67759228_+_3003nt ATGGCAGAACTCAAGGTGGAGGCGCCGGCCAGCGTAGACTGGCAGAAACGCTGCCTGACCCTGGAAACTCAGCTTTTCCGGTTCCGCCTA CAGGCCAGCAAGATAAGGGAGCTGCTGGCTGACAAGATGCAGGAGCTGGAGCAGAGGCTGCTGGAGGCAGAGCAGAGAGCAGAGAACGCT GAGACCCAGGTGGGTGTCATGGAAGAGAAGGTAAAACTATCCAATCTGAAGAATGTGGACTCTGAGGGGAGCCTGCACCGGAAATACCAA GAATTGCTGAAAGCCATAAAGGGCAAAGATGAGCTCATCAGCCAGCTAGAGGCTCAGCTGGAGAAGCAGAAGCAGATGAGGGCAGAGGAA GCAAAAACTGTTCAAGAAAAAGCTGCAAAGATCAAGGAATGGGTGACACTCAAGTTGGCAAAGCTTGAGATGGAGAATCAGCATCTGAAA AGCCATAATCAGCGCCTGGTGGAGCAGGTGGGATCCCTTCAAGATGCGCTAGAAGCTATTCAGATAGCTCCTTCACGGAAGCTGCTGGTG CCCCCCTACGGAGCTGCAGAGCAGGATTCTGTCCCTTCAGAGCCGGGAATCCAGCCTATGGGCCAGGACAGTGGCTCCCAGGCCCAGGGT CTGAAGGCAGCTGTGCTTGCACCTTCCCCAGGTGCCCTGCAGAGCAAGGACTCTGTTTCTGAAGCAGCAAGCCCCTTGGAGGATTCTAGT TCCAGCACGGTCCATTCTGGGGAAACAGTAGAGGCCAAGCCCCTTCAACCTCATCTGGGAAGAGAGAGCCCTCCCCACCAGCCATGCATG AAGCTTCTTACCTTCAGATGTAGTTCAGCTTCCTGGGGTGAGGGTCTGGTTACTGCTCAGAGAGGGATGCTCCCTGGGACAAAGACCTCT GCCAGGGAAGGTGGTCCTGGCAGCAGTCTGACCCTACCAAAGGTGCGGGCTCCTGGCACCCCGCGGGACAGCATCCAGTTGGCCAAAAGG CACCACAGCCAGCCCCAGGTGGGCCATGGGCACTTTGGCCGTGTGGTGAACATTGAGACTGAGGCCTTCTCAGCCCTCCACCCCTCTGGC CTTCCTGAGCTGGAGTCCCGAGCTAGGTCCCGGGAGGAACCAGAGAAGATGGAGATGGAGGAGCCACCCCCAGCAGGGAAGAATGAGGAA AGAGAGAGCCCAAAGGCCCTTGGAGCTGAGCTGGAGGAAGTGGAGCTGGGTAACAAGCCACCTACACCCCCGCTGCACCAGTTTTCATCC TGGGAGAGCCGGATCTATGCTGTGGCCACATCGGGCATGCGGCTCTCAGATATGTCTCCCAGAAGTAATACTGCATGCTGCGAAATAGAA GACTTGTTTTCTTCACTTAAACATATCCAACATACTTTGGTAGATTCTCAGAGCCAGGAGGATATTTCACTGCTTTTACAACTTGTTCAA AATAAGGATTTCCAGAATGCATTTAAGATACACAATGCCATCACAGTACACATGAACAAGGCCAGTCCTCCATTTCCTCTTATCTCCAAC GCACAAGATCTTGCTCAAGAGGTACAAACTGTTTTGAAGCCAGTTCATCATAAGGAAGGACAAGAACTAACTGCTTTGCTGAATACTCCA CATATTCAGGCACTTTTACTGGCCCACGATAAGGTTGCTGAGCAGGAAATGCAGCTAGAGCCCATTACAGATGAGAGAGTTTATGAAAGT ATTGGCCAGTATGGAGGAGAAACTGTAAAAATAGTTCGTATAGAAAAGGCTCGTGATATTCCGTTGGGTGCTACAGTTCGTAATGAAATG GACTCTGTCATCATTAGCCGGATAGTAAAAGGGGGTGCTGCAGAGAAAAGTGGTCTGTTGCATGAAGGAGATGAAGTTCTAGAGATTAAT GGCATTGAAATTCGGGGGAAAGATGTCAATGAGGTTTTTGACTTGTTGTCTGATATGCATGGTACTTTGACTTTTGTCCTGATTCCCAGT CAACAGATCAAGCCGCCTCCTGCCAAGGAAACAGTAATCCATGTAAAAGCTCATTTTGACTATGACCCCTCAGATGACCCTTATGTTCCA TGTCGAGAGTTAGGTCTGTCTTTTCAAAAAGGTGATATACTTCATGTGATCAGTCAAGAAGATCCAAACTGGTGGCAGGCCTACAGGGAA GGGGACGAAGATAATCAACCTCTAGCCGGGCTTGTTCCAGGGAAAAGCTTTCAGCAGCAAAGGGAAGCCATGAAACAAACCATAGAAGAA GATAAGGAGCCAGAAAAATCAGGAAAACTGTGGTGTGCAAAGAAGAATAAAAAGAAGAGGAAAAAGGTTTTATATAATGCCAATAAAAAT GATGATTATGACAACGAGGAGATCTTAACCTATGAGGAAATGTCACTTTATCATCAGCCAGCAAATAGGAAGAGACCTATCATCTTGATT GGTCCACAGAACTGTGGCCAGAATGAATTGCGTCAGAGGCTCATGAACAAAGAAAAGGACCGCTTTGCATCTGCAGTTCCTCATACAACC CGGAGTAGGCGAGACCAAGAAGTAGCCGGTAGAGATTACCACTTTGTTTCGCGGCAAGCATTCGAGGCAGACATAGCAGCTGGAAAGTTC ATTGAGCATGGTGAATTTGAGAAGAATTTGTATGGAACTAGCATAGATTCTGTACGGCAAGTGATCAACTCTGGCAAAATATGTCTTTTA AGTCTTCGTACACAGTCATTGAAGACTCTCCGGAATTCAGATTTGAAACCATATATTATCTTCATTGCACCCCCTTCACAAGAAAGACTT CGGGCATTATTGGCCAAAGAAGGCAAGAATCCAAAGCCTGAAGAGTTGAGAGAAATCATTGAGAAGACAAGAGAGATGGAGCAGAACAAT GGCCACTACTTTGATACGGCAATTGTGAATTCCGATCTTGATAAAGCCTATCAGGAATTGCTTAGGTTAATTAACAAACTTGATACTGAA >In-frame_PLEKHH1_ENST00000329153_chr14_68035933_+_MPP5_ENST00000555925_chr14_67759228_+_3003nt ATGGCAGAACTCAAGGTGGAGGCGCCGGCCAGCGTAGACTGGCAGAAACGCTGCCTGACCCTGGAAACTCAGCTTTTCCGGTTCCGCCTA CAGGCCAGCAAGATAAGGGAGCTGCTGGCTGACAAGATGCAGGAGCTGGAGCAGAGGCTGCTGGAGGCAGAGCAGAGAGCAGAGAACGCT GAGACCCAGGTGGGTGTCATGGAAGAGAAGGTAAAACTATCCAATCTGAAGAATGTGGACTCTGAGGGGAGCCTGCACCGGAAATACCAA GAATTGCTGAAAGCCATAAAGGGCAAAGATGAGCTCATCAGCCAGCTAGAGGCTCAGCTGGAGAAGCAGAAGCAGATGAGGGCAGAGGAA GCAAAAACTGTTCAAGAAAAAGCTGCAAAGATCAAGGAATGGGTGACACTCAAGTTGGCAAAGCTTGAGATGGAGAATCAGCATCTGAAA AGCCATAATCAGCGCCTGGTGGAGCAGGTGGGATCCCTTCAAGATGCGCTAGAAGCTATTCAGATAGCTCCTTCACGGAAGCTGCTGGTG CCCCCCTACGGAGCTGCAGAGCAGGATTCTGTCCCTTCAGAGCCGGGAATCCAGCCTATGGGCCAGGACAGTGGCTCCCAGGCCCAGGGT CTGAAGGCAGCTGTGCTTGCACCTTCCCCAGGTGCCCTGCAGAGCAAGGACTCTGTTTCTGAAGCAGCAAGCCCCTTGGAGGATTCTAGT TCCAGCACGGTCCATTCTGGGGAAACAGTAGAGGCCAAGCCCCTTCAACCTCATCTGGGAAGAGAGAGCCCTCCCCACCAGCCATGCATG AAGCTTCTTACCTTCAGATGTAGTTCAGCTTCCTGGGGTGAGGGTCTGGTTACTGCTCAGAGAGGGATGCTCCCTGGGACAAAGACCTCT GCCAGGGAAGGTGGTCCTGGCAGCAGTCTGACCCTACCAAAGGTGCGGGCTCCTGGCACCCCGCGGGACAGCATCCAGTTGGCCAAAAGG CACCACAGCCAGCCCCAGGTGGGCCATGGGCACTTTGGCCGTGTGGTGAACATTGAGACTGAGGCCTTCTCAGCCCTCCACCCCTCTGGC CTTCCTGAGCTGGAGTCCCGAGCTAGGTCCCGGGAGGAACCAGAGAAGATGGAGATGGAGGAGCCACCCCCAGCAGGGAAGAATGAGGAA AGAGAGAGCCCAAAGGCCCTTGGAGCTGAGCTGGAGGAAGTGGAGCTGGGTAACAAGCCACCTACACCCCCGCTGCACCAGTTTTCATCC TGGGAGAGCCGGATCTATGCTGTGGCCACATCGGGCATGCGGCTCTCAGATATGTCTCCCAGAAGTAATACTGCATGCTGCGAAATAGAA GACTTGTTTTCTTCACTTAAACATATCCAACATACTTTGGTAGATTCTCAGAGCCAGGAGGATATTTCACTGCTTTTACAACTTGTTCAA AATAAGGATTTCCAGAATGCATTTAAGATACACAATGCCATCACAGTACACATGAACAAGGCCAGTCCTCCATTTCCTCTTATCTCCAAC GCACAAGATCTTGCTCAAGAGGTACAAACTGTTTTGAAGCCAGTTCATCATAAGGAAGGACAAGAACTAACTGCTTTGCTGAATACTCCA CATATTCAGGCACTTTTACTGGCCCACGATAAGGTTGCTGAGCAGGAAATGCAGCTAGAGCCCATTACAGATGAGAGAGTTTATGAAAGT ATTGGCCAGTATGGAGGAGAAACTGTAAAAATAGTTCGTATAGAAAAGGCTCGTGATATTCCGTTGGGTGCTACAGTTCGTAATGAAATG GACTCTGTCATCATTAGCCGGATAGTAAAAGGGGGTGCTGCAGAGAAAAGTGGTCTGTTGCATGAAGGAGATGAAGTTCTAGAGATTAAT GGCATTGAAATTCGGGGGAAAGATGTCAATGAGGTTTTTGACTTGTTGTCTGATATGCATGGTACTTTGACTTTTGTCCTGATTCCCAGT CAACAGATCAAGCCGCCTCCTGCCAAGGAAACAGTAATCCATGTAAAAGCTCATTTTGACTATGACCCCTCAGATGACCCTTATGTTCCA TGTCGAGAGTTAGGTCTGTCTTTTCAAAAAGGTGATATACTTCATGTGATCAGTCAAGAAGATCCAAACTGGTGGCAGGCCTACAGGGAA GGGGACGAAGATAATCAACCTCTAGCCGGGCTTGTTCCAGGGAAAAGCTTTCAGCAGCAAAGGGAAGCCATGAAACAAACCATAGAAGAA GATAAGGAGCCAGAAAAATCAGGAAAACTGTGGTGTGCAAAGAAGAATAAAAAGAAGAGGAAAAAGGTTTTATATAATGCCAATAAAAAT GATGATTATGACAACGAGGAGATCTTAACCTATGAGGAAATGTCACTTTATCATCAGCCAGCAAATAGGAAGAGACCTATCATCTTGATT GGTCCACAGAACTGTGGCCAGAATGAATTGCGTCAGAGGCTCATGAACAAAGAAAAGGACCGCTTTGCATCTGCAGTTCCTCATACAACC CGGAGTAGGCGAGACCAAGAAGTAGCCGGTAGAGATTACCACTTTGTTTCGCGGCAAGCATTCGAGGCAGACATAGCAGCTGGAAAGTTC ATTGAGCATGGTGAATTTGAGAAGAATTTGTATGGAACTAGCATAGATTCTGTACGGCAAGTGATCAACTCTGGCAAAATATGTCTTTTA AGTCTTCGTACACAGTCATTGAAGACTCTCCGGAATTCAGATTTGAAACCATATATTATCTTCATTGCACCCCCTTCACAAGAAAGACTT CGGGCATTATTGGCCAAAGAAGGCAAGAATCCAAAGCCTGAAGAGTTGAGAGAAATCATTGAGAAGACAAGAGAGATGGAGCAGAACAAT GGCCACTACTTTGATACGGCAATTGTGAATTCCGATCTTGATAAAGCCTATCAGGAATTGCTTAGGTTAATTAACAAACTTGATACTGAA |
| * Fusion transcript sequences (Full-length transcript). |
| >In-frame_PLEKHH1_ENST00000329153_chr14_68035933_+_MPP5_ENST00000261681_chr14_67759228_+_5998nt GGGACTCCGGCGAGAGCGACGCAAGGTCGGCTGCGGCGGCGGCCCGAGGGCGCCCGTGTGCCCAGTGCGCGGCGGGGACGGCCGCGAGCT CGCTGGAGGGCTCCCCAGAATAATCCAGAAGTCGATTCCATCATGGCAGAACTCAAGGTGGAGGCGCCGGCCAGCGTAGACTGGCAGAAA CGCTGCCTGACCCTGGAAACTCAGCTTTTCCGGTTCCGCCTACAGGCCAGCAAGATAAGGGAGCTGCTGGCTGACAAGATGCAGGAGCTG GAGCAGAGGCTGCTGGAGGCAGAGCAGAGAGCAGAGAACGCTGAGACCCAGGTGGGTGTCATGGAAGAGAAGGTAAAACTATCCAATCTG AAGAATGTGGACTCTGAGGGGAGCCTGCACCGGAAATACCAAGAATTGCTGAAAGCCATAAAGGGCAAAGATGAGCTCATCAGCCAGCTA GAGGCTCAGCTGGAGAAGCAGAAGCAGATGAGGGCAGAGGAAGCAAAAACTGTTCAAGAAAAAGCTGCAAAGATCAAGGAATGGGTGACA CTCAAGTTGGCAAAGCTTGAGATGGAGAATCAGCATCTGAAAAGCCATAATCAGCGCCTGGTGGAGCAGGTGGGATCCCTTCAAGATGCG CTAGAAGCTATTCAGATAGCTCCTTCACGGAAGCTGCTGGTGCCCCCCTACGGAGCTGCAGAGCAGGATTCTGTCCCTTCAGAGCCGGGA ATCCAGCCTATGGGCCAGGACAGTGGCTCCCAGGCCCAGGGTCTGAAGGCAGCTGTGCTTGCACCTTCCCCAGGTGCCCTGCAGAGCAAG GACTCTGTTTCTGAAGCAGCAAGCCCCTTGGAGGATTCTAGTTCCAGCACGGTCCATTCTGGGGAAACAGTAGAGGCCAAGCCCCTTCAA CCTCATCTGGGAAGAGAGAGCCCTCCCCACCAGCCATGCATGAAGCTTCTTACCTTCAGATGTAGTTCAGCTTCCTGGGGTGAGGGTCTG GTTACTGCTCAGAGAGGGATGCTCCCTGGGACAAAGACCTCTGCCAGGGAAGGTGGTCCTGGCAGCAGTCTGACCCTACCAAAGGTGCGG GCTCCTGGCACCCCGCGGGACAGCATCCAGTTGGCCAAAAGGCACCACAGCCAGCCCCAGGTGGGCCATGGGCACTTTGGCCGTGTGGTG AACATTGAGACTGAGGCCTTCTCAGCCCTCCACCCCTCTGGCCTTCCTGAGCTGGAGTCCCGAGCTAGGTCCCGGGAGGAACCAGAGAAG ATGGAGATGGAGGAGCCACCCCCAGCAGGGAAGAATGAGGAAAGAGAGAGCCCAAAGGCCCTTGGAGCTGAGCTGGAGGAAGTGGAGCTG GGTAACAAGCCACCTACACCCCCGCTGCACCAGTTTTCATCCTGGGAGAGCCGGATCTATGCTGTGGCCACATCGGGCATGCGGCTCTCA GATATGTCTCCCAGAAGTAATACTGCATGCTGCGAAATAGAAGACTTGTTTTCTTCACTTAAACATATCCAACATACTTTGGTAGATTCT CAGAGCCAGGAGGATATTTCACTGCTTTTACAACTTGTTCAAAATAAGGATTTCCAGAATGCATTTAAGATACACAATGCCATCACAGTA CACATGAACAAGGCCAGTCCTCCATTTCCTCTTATCTCCAACGCACAAGATCTTGCTCAAGAGGTACAAACTGTTTTGAAGCCAGTTCAT CATAAGGAAGGACAAGAACTAACTGCTTTGCTGAATACTCCACATATTCAGGCACTTTTACTGGCCCACGATAAGGTTGCTGAGCAGGAA ATGCAGCTAGAGCCCATTACAGATGAGAGAGTTTATGAAAGTATTGGCCAGTATGGAGGAGAAACTGTAAAAATAGTTCGTATAGAAAAG GCTCGTGATATTCCGTTGGGTGCTACAGTTCGTAATGAAATGGACTCTGTCATCATTAGCCGGATAGTAAAAGGGGGTGCTGCAGAGAAA AGTGGTCTGTTGCATGAAGGAGATGAAGTTCTAGAGATTAATGGCATTGAAATTCGGGGGAAAGATGTCAATGAGGTTTTTGACTTGTTG TCTGATATGCATGGTACTTTGACTTTTGTCCTGATTCCCAGTCAACAGATCAAGCCGCCTCCTGCCAAGGAAACAGTAATCCATGTAAAA GCTCATTTTGACTATGACCCCTCAGATGACCCTTATGTTCCATGTCGAGAGTTAGGTCTGTCTTTTCAAAAAGGTGATATACTTCATGTG ATCAGTCAAGAAGATCCAAACTGGTGGCAGGCCTACAGGGAAGGGGACGAAGATAATCAACCTCTAGCCGGGCTTGTTCCAGGGAAAAGC TTTCAGCAGCAAAGGGAAGCCATGAAACAAACCATAGAAGAAGATAAGGAGCCAGAAAAATCAGGAAAACTGTGGTGTGCAAAGAAGAAT AAAAAGAAGAGGAAAAAGGTTTTATATAATGCCAATAAAAATGATGATTATGACAACGAGGAGATCTTAACCTATGAGGAAATGTCACTT TATCATCAGCCAGCAAATAGGAAGAGACCTATCATCTTGATTGGTCCACAGAACTGTGGCCAGAATGAATTGCGTCAGAGGCTCATGAAC AAAGAAAAGGACCGCTTTGCATCTGCAGTTCCTCATACAACCCGGAGTAGGCGAGACCAAGAAGTAGCCGGTAGAGATTACCACTTTGTT TCGCGGCAAGCATTCGAGGCAGACATAGCAGCTGGAAAGTTCATTGAGCATGGTGAATTTGAGAAGAATTTGTATGGAACTAGCATAGAT TCTGTACGGCAAGTGATCAACTCTGGCAAAATATGTCTTTTAAGTCTTCGTACACAGTCATTGAAGACTCTCCGGAATTCAGATTTGAAA CCATATATTATCTTCATTGCACCCCCTTCACAAGAAAGACTTCGGGCATTATTGGCCAAAGAAGGCAAGAATCCAAAGCCTGAAGAGTTG AGAGAAATCATTGAGAAGACAAGAGAGATGGAGCAGAACAATGGCCACTACTTTGATACGGCAATTGTGAATTCCGATCTTGATAAAGCC TATCAGGAATTGCTTAGGTTAATTAACAAACTTGATACTGAACCTCAGTGGGTACCATCCACTTGGCTGAGGTGAAAGAAACATCCATTC TGTGGCATGTTGGACTTGATCTGGCAAAAACTGCCAATAGGAGGACTGCCCGACACTGCAGCAAGATTGAGGATAAGATGGAAGGCAGCA GTATAAGCTGTAGATCTGTTCTTAGATCTCTTGAATTAGTGAGACGACAGTTCCCTTAGGCAGTTTGTGCATGGCATCCTTTATTCTCTA TACATGGCTTTAGCGGTTCTTGCCTCATTTTGGGATTCTAAATGGAAGCTTTCAACAGAGCATTCCATTTTGTCCTGTTAAAACCTTTTG TTTTCACCTAAACCCTTTCTGCTTAGTTGTATCTCTGTGAAAAACTTGTATACACAAGCGTCCATGTCTCACACAAATATTGATGTGATT ATTCTTAAGTGTTAAATCATTAACACTTAAATGACTTCATTGGGAATATTGAGCAGAGGGACTGTGCTTCTATGCACTGGGCAAGGCAGT ATTTGCTTAGGAAACTAATTTAGTCATCAGAGATACTTTCCTAAAAAGGAAAAATAAAAAACAAAATGGTGCCACTTTGGGTTGAAGCTA CTTTGTTAGGCTTGAATTCATTTATATGTCTTTTGATTCTTAAAAAAACAAAAAACATTCCATTAGAAGCACCAGTTTTTTTGCTCAGAC TTTGTGGATCAGACTCTACACTCAACACACTCTAATCTACTTAAAGGTATACAAAATATGCTGATCTTTTTTAAATTATGATTTCCTGAA TTTTTTTCTTAAGTCGTCTCAACTGATTTACTCACTTAGCTTCCCTTCCCTCATCAGCATAGTATAATAGAATGTATGTTACATTTTTAT GAATGGCAGGTGTTCATTATAATCTGTATTGACTTAAAAAGTTTCTTCCTCATGATGCTAATAGTTTTTTGTATACATGGGAGGATAGCA CATTTGACAGTTTTTGCATTTTTATGTATGAGCACAGTATCCTATGACTGTGCTACGTATATATAGGTAATAAACTGGAATTCTGTTGAT GAATATAGCTGCTGTACTGTATATTAATATTTAATAGATCAACAAATGGTCATTGAAAACACTTGTTTAGCATTAGAATAAAATTATATA TGTCCTTGGGAAATATTATGACAGTTGACTTTAAGATCAAAAGGAAGGGAAGACCTGAAAGTCATTTGAACATTTTAGGAAAAGAATATT GGAGAGAAAAAGGTATTAAATATATAGAAATAGGTTTTTAACCTAACAAGGTCTGCCTCTTATGACGAGAATGCAACAGCTTGGTAAATC ATAAAAGAAACATTTAAGCTAATAGGATTTTCGTACTGTCTCTATAGCTGTAGCTTTAAAATTCAACGTATATAATTGGCATGGAAACTT AATTTGCAGTCTTTTCAAGCCTTTAGGATAGTGTGATGTGTAACAAACAACCTCAAATGTGAATGCCTTGATTTTATTTTTATGGTGACT TTAGCTACAGCATTTCCTATACCCAGAGCTAAACACTGGAATAATACTGACATCATTTAATTTAACATAAGCAATTATGTTTAAGGAGTA ATTTGTGTCATGTACATATTTGATTGATTTTTTTTCTTCTACATAATTTTATTTGAACAAATGTAGACAGTTTATATGTCGCCTTTTTCT GTTCAAATTTGCATGGCCTATTAAGTTGGCTGGAGAGTGTTTTATGTGGAAATATTTTCAAGATAATGTTCCTTAGGAAGAAAATAACAT TCTTGGGTTGAGGGAAGGAATGCCATACACTACTGTCTCTTCAGATCTGAAATACTCCAGTTTAGAGCCAGGAAATTTCACAGGTCACAC CGATTTTTAGCATTAAAAACTAAGGAATATACTTAGCACTTACTTAATCTTTTCAGTTTTCCAGTTTACGTCTCAGGAATGAAGTGTAGT CTATGGTTGACAATGGAGTTTTGTGATCCTGCTTATTGTAACTGACAACTGTTTTCAACTCCAAGAGCTAAACTATTGGCAGTTCATGTT AAGTTAGAGTGAGGGTGTAGGTAGTGTCAGTGAGTGGCTCTTGTGCCTGCTGTAGACATTAGGCCTGCACTAGGGCCATGTGCTGTCAAG ATTCAGGAACATGGCTTTAACAAGCAGATCTTGTATCAAGGCAGAGGTGATGCCATGCCATACTTTTAGGAAGTCTGAGATGATAAATAT TTCAAGGTCAGTGAAGTCTATCAATCATTCTCCCCTTCCTCATCAGCAATGGTAGATAGAAATGTCCTAAACTTTTCTAAATCCTAGTGA TGAGGATGTGCTGATATTCAACATAGTCCTTAAAGTGAAAACTGAGTTGTTGCTGACCTCCACAAAAGAATATGGAAAAAAGCCTTGCTG TACACCTAGTTGTACAGCCACTCTGGCCAATTCCATTTCCTGTCCCTCTGTGGTTCTGACTGGAGACCCCAGTGTGGGGGAGGTCTTACC ATTTAATATAGAAATGATATCAATAACTAATGCTATGTACTTGGAAAATCCAAATAAGGAAGTTTTAGGTTGGTGCATAACTTTGTTTCT CAAATTTTCGTTGTCAGAACAAATGGAAGGAGAATATTATTTAGACTAATCCAGATTTGCTTTCTATGAAAATCTAATGTCTGGATTATC TTCCTTTTCTCATGGCCTAAGAAATAAGGATCAATAAGGAATGATTTGAATGTAATTTTGTGAATGTGTGGAAAATATAAAGCAGGGATT TAGCCTTAATAAAGGTAACCTTCTGACATCTGTTGTTAATCCCCCTTTGTACTCTTTTCCTGTATCTGCACTGTTATTTTGAGATGTCAT >In-frame_PLEKHH1_ENST00000329153_chr14_68035933_+_MPP5_ENST00000555925_chr14_67759228_+_5998nt GGGACTCCGGCGAGAGCGACGCAAGGTCGGCTGCGGCGGCGGCCCGAGGGCGCCCGTGTGCCCAGTGCGCGGCGGGGACGGCCGCGAGCT CGCTGGAGGGCTCCCCAGAATAATCCAGAAGTCGATTCCATCATGGCAGAACTCAAGGTGGAGGCGCCGGCCAGCGTAGACTGGCAGAAA CGCTGCCTGACCCTGGAAACTCAGCTTTTCCGGTTCCGCCTACAGGCCAGCAAGATAAGGGAGCTGCTGGCTGACAAGATGCAGGAGCTG GAGCAGAGGCTGCTGGAGGCAGAGCAGAGAGCAGAGAACGCTGAGACCCAGGTGGGTGTCATGGAAGAGAAGGTAAAACTATCCAATCTG AAGAATGTGGACTCTGAGGGGAGCCTGCACCGGAAATACCAAGAATTGCTGAAAGCCATAAAGGGCAAAGATGAGCTCATCAGCCAGCTA GAGGCTCAGCTGGAGAAGCAGAAGCAGATGAGGGCAGAGGAAGCAAAAACTGTTCAAGAAAAAGCTGCAAAGATCAAGGAATGGGTGACA CTCAAGTTGGCAAAGCTTGAGATGGAGAATCAGCATCTGAAAAGCCATAATCAGCGCCTGGTGGAGCAGGTGGGATCCCTTCAAGATGCG CTAGAAGCTATTCAGATAGCTCCTTCACGGAAGCTGCTGGTGCCCCCCTACGGAGCTGCAGAGCAGGATTCTGTCCCTTCAGAGCCGGGA ATCCAGCCTATGGGCCAGGACAGTGGCTCCCAGGCCCAGGGTCTGAAGGCAGCTGTGCTTGCACCTTCCCCAGGTGCCCTGCAGAGCAAG GACTCTGTTTCTGAAGCAGCAAGCCCCTTGGAGGATTCTAGTTCCAGCACGGTCCATTCTGGGGAAACAGTAGAGGCCAAGCCCCTTCAA CCTCATCTGGGAAGAGAGAGCCCTCCCCACCAGCCATGCATGAAGCTTCTTACCTTCAGATGTAGTTCAGCTTCCTGGGGTGAGGGTCTG GTTACTGCTCAGAGAGGGATGCTCCCTGGGACAAAGACCTCTGCCAGGGAAGGTGGTCCTGGCAGCAGTCTGACCCTACCAAAGGTGCGG GCTCCTGGCACCCCGCGGGACAGCATCCAGTTGGCCAAAAGGCACCACAGCCAGCCCCAGGTGGGCCATGGGCACTTTGGCCGTGTGGTG AACATTGAGACTGAGGCCTTCTCAGCCCTCCACCCCTCTGGCCTTCCTGAGCTGGAGTCCCGAGCTAGGTCCCGGGAGGAACCAGAGAAG ATGGAGATGGAGGAGCCACCCCCAGCAGGGAAGAATGAGGAAAGAGAGAGCCCAAAGGCCCTTGGAGCTGAGCTGGAGGAAGTGGAGCTG GGTAACAAGCCACCTACACCCCCGCTGCACCAGTTTTCATCCTGGGAGAGCCGGATCTATGCTGTGGCCACATCGGGCATGCGGCTCTCA GATATGTCTCCCAGAAGTAATACTGCATGCTGCGAAATAGAAGACTTGTTTTCTTCACTTAAACATATCCAACATACTTTGGTAGATTCT CAGAGCCAGGAGGATATTTCACTGCTTTTACAACTTGTTCAAAATAAGGATTTCCAGAATGCATTTAAGATACACAATGCCATCACAGTA CACATGAACAAGGCCAGTCCTCCATTTCCTCTTATCTCCAACGCACAAGATCTTGCTCAAGAGGTACAAACTGTTTTGAAGCCAGTTCAT CATAAGGAAGGACAAGAACTAACTGCTTTGCTGAATACTCCACATATTCAGGCACTTTTACTGGCCCACGATAAGGTTGCTGAGCAGGAA ATGCAGCTAGAGCCCATTACAGATGAGAGAGTTTATGAAAGTATTGGCCAGTATGGAGGAGAAACTGTAAAAATAGTTCGTATAGAAAAG GCTCGTGATATTCCGTTGGGTGCTACAGTTCGTAATGAAATGGACTCTGTCATCATTAGCCGGATAGTAAAAGGGGGTGCTGCAGAGAAA AGTGGTCTGTTGCATGAAGGAGATGAAGTTCTAGAGATTAATGGCATTGAAATTCGGGGGAAAGATGTCAATGAGGTTTTTGACTTGTTG TCTGATATGCATGGTACTTTGACTTTTGTCCTGATTCCCAGTCAACAGATCAAGCCGCCTCCTGCCAAGGAAACAGTAATCCATGTAAAA GCTCATTTTGACTATGACCCCTCAGATGACCCTTATGTTCCATGTCGAGAGTTAGGTCTGTCTTTTCAAAAAGGTGATATACTTCATGTG ATCAGTCAAGAAGATCCAAACTGGTGGCAGGCCTACAGGGAAGGGGACGAAGATAATCAACCTCTAGCCGGGCTTGTTCCAGGGAAAAGC TTTCAGCAGCAAAGGGAAGCCATGAAACAAACCATAGAAGAAGATAAGGAGCCAGAAAAATCAGGAAAACTGTGGTGTGCAAAGAAGAAT AAAAAGAAGAGGAAAAAGGTTTTATATAATGCCAATAAAAATGATGATTATGACAACGAGGAGATCTTAACCTATGAGGAAATGTCACTT TATCATCAGCCAGCAAATAGGAAGAGACCTATCATCTTGATTGGTCCACAGAACTGTGGCCAGAATGAATTGCGTCAGAGGCTCATGAAC AAAGAAAAGGACCGCTTTGCATCTGCAGTTCCTCATACAACCCGGAGTAGGCGAGACCAAGAAGTAGCCGGTAGAGATTACCACTTTGTT TCGCGGCAAGCATTCGAGGCAGACATAGCAGCTGGAAAGTTCATTGAGCATGGTGAATTTGAGAAGAATTTGTATGGAACTAGCATAGAT TCTGTACGGCAAGTGATCAACTCTGGCAAAATATGTCTTTTAAGTCTTCGTACACAGTCATTGAAGACTCTCCGGAATTCAGATTTGAAA CCATATATTATCTTCATTGCACCCCCTTCACAAGAAAGACTTCGGGCATTATTGGCCAAAGAAGGCAAGAATCCAAAGCCTGAAGAGTTG AGAGAAATCATTGAGAAGACAAGAGAGATGGAGCAGAACAATGGCCACTACTTTGATACGGCAATTGTGAATTCCGATCTTGATAAAGCC TATCAGGAATTGCTTAGGTTAATTAACAAACTTGATACTGAACCTCAGTGGGTACCATCCACTTGGCTGAGGTGAAAGAAACATCCATTC TGTGGCATGTTGGACTTGATCTGGCAAAAACTGCCAATAGGAGGACTGCCCGACACTGCAGCAAGATTGAGGATAAGATGGAAGGCAGCA GTATAAGCTGTAGATCTGTTCTTAGATCTCTTGAATTAGTGAGACGACAGTTCCCTTAGGCAGTTTGTGCATGGCATCCTTTATTCTCTA TACATGGCTTTAGCGGTTCTTGCCTCATTTTGGGATTCTAAATGGAAGCTTTCAACAGAGCATTCCATTTTGTCCTGTTAAAACCTTTTG TTTTCACCTAAACCCTTTCTGCTTAGTTGTATCTCTGTGAAAAACTTGTATACACAAGCGTCCATGTCTCACACAAATATTGATGTGATT ATTCTTAAGTGTTAAATCATTAACACTTAAATGACTTCATTGGGAATATTGAGCAGAGGGACTGTGCTTCTATGCACTGGGCAAGGCAGT ATTTGCTTAGGAAACTAATTTAGTCATCAGAGATACTTTCCTAAAAAGGAAAAATAAAAAACAAAATGGTGCCACTTTGGGTTGAAGCTA CTTTGTTAGGCTTGAATTCATTTATATGTCTTTTGATTCTTAAAAAAACAAAAAACATTCCATTAGAAGCACCAGTTTTTTTGCTCAGAC TTTGTGGATCAGACTCTACACTCAACACACTCTAATCTACTTAAAGGTATACAAAATATGCTGATCTTTTTTAAATTATGATTTCCTGAA TTTTTTTCTTAAGTCGTCTCAACTGATTTACTCACTTAGCTTCCCTTCCCTCATCAGCATAGTATAATAGAATGTATGTTACATTTTTAT GAATGGCAGGTGTTCATTATAATCTGTATTGACTTAAAAAGTTTCTTCCTCATGATGCTAATAGTTTTTTGTATACATGGGAGGATAGCA CATTTGACAGTTTTTGCATTTTTATGTATGAGCACAGTATCCTATGACTGTGCTACGTATATATAGGTAATAAACTGGAATTCTGTTGAT GAATATAGCTGCTGTACTGTATATTAATATTTAATAGATCAACAAATGGTCATTGAAAACACTTGTTTAGCATTAGAATAAAATTATATA TGTCCTTGGGAAATATTATGACAGTTGACTTTAAGATCAAAAGGAAGGGAAGACCTGAAAGTCATTTGAACATTTTAGGAAAAGAATATT GGAGAGAAAAAGGTATTAAATATATAGAAATAGGTTTTTAACCTAACAAGGTCTGCCTCTTATGACGAGAATGCAACAGCTTGGTAAATC ATAAAAGAAACATTTAAGCTAATAGGATTTTCGTACTGTCTCTATAGCTGTAGCTTTAAAATTCAACGTATATAATTGGCATGGAAACTT AATTTGCAGTCTTTTCAAGCCTTTAGGATAGTGTGATGTGTAACAAACAACCTCAAATGTGAATGCCTTGATTTTATTTTTATGGTGACT TTAGCTACAGCATTTCCTATACCCAGAGCTAAACACTGGAATAATACTGACATCATTTAATTTAACATAAGCAATTATGTTTAAGGAGTA ATTTGTGTCATGTACATATTTGATTGATTTTTTTTCTTCTACATAATTTTATTTGAACAAATGTAGACAGTTTATATGTCGCCTTTTTCT GTTCAAATTTGCATGGCCTATTAAGTTGGCTGGAGAGTGTTTTATGTGGAAATATTTTCAAGATAATGTTCCTTAGGAAGAAAATAACAT TCTTGGGTTGAGGGAAGGAATGCCATACACTACTGTCTCTTCAGATCTGAAATACTCCAGTTTAGAGCCAGGAAATTTCACAGGTCACAC CGATTTTTAGCATTAAAAACTAAGGAATATACTTAGCACTTACTTAATCTTTTCAGTTTTCCAGTTTACGTCTCAGGAATGAAGTGTAGT CTATGGTTGACAATGGAGTTTTGTGATCCTGCTTATTGTAACTGACAACTGTTTTCAACTCCAAGAGCTAAACTATTGGCAGTTCATGTT AAGTTAGAGTGAGGGTGTAGGTAGTGTCAGTGAGTGGCTCTTGTGCCTGCTGTAGACATTAGGCCTGCACTAGGGCCATGTGCTGTCAAG ATTCAGGAACATGGCTTTAACAAGCAGATCTTGTATCAAGGCAGAGGTGATGCCATGCCATACTTTTAGGAAGTCTGAGATGATAAATAT TTCAAGGTCAGTGAAGTCTATCAATCATTCTCCCCTTCCTCATCAGCAATGGTAGATAGAAATGTCCTAAACTTTTCTAAATCCTAGTGA TGAGGATGTGCTGATATTCAACATAGTCCTTAAAGTGAAAACTGAGTTGTTGCTGACCTCCACAAAAGAATATGGAAAAAAGCCTTGCTG TACACCTAGTTGTACAGCCACTCTGGCCAATTCCATTTCCTGTCCCTCTGTGGTTCTGACTGGAGACCCCAGTGTGGGGGAGGTCTTACC ATTTAATATAGAAATGATATCAATAACTAATGCTATGTACTTGGAAAATCCAAATAAGGAAGTTTTAGGTTGGTGCATAACTTTGTTTCT CAAATTTTCGTTGTCAGAACAAATGGAAGGAGAATATTATTTAGACTAATCCAGATTTGCTTTCTATGAAAATCTAATGTCTGGATTATC TTCCTTTTCTCATGGCCTAAGAAATAAGGATCAATAAGGAATGATTTGAATGTAATTTTGTGAATGTGTGGAAAATATAAAGCAGGGATT TAGCCTTAATAAAGGTAACCTTCTGACATCTGTTGTTAATCCCCCTTTGTACTCTTTTCCTGTATCTGCACTGTTATTTTGAGATGTCAT |
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FusionGenePPI for PLEKHH1_MPP5 |
| Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in . |
| Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160) |
| Hgene | Hgene's interactors | Tgene | Tgene's interactors |
| PLEKHH1 | APBB1IP, LPXN | MPP5 | INADL, PARD6A, AMOT, ARHGAP17, LIN7A, ZNF451, AMOTL2, LATS1, LATS2, YAP1, WWOX, LIN7C, AMOTL1, MPDZ, SOCS4, CEP128, NINL, RPH3A, LIN7B, HOMER3, ALOX5, PCDHAC2, RNF19B, SH3KBP1, GAK, STXBP4, WWC1 |
| - Retained PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
| Tgene | MPP5 | chr14:68035933 | chr14:67759228 | ENST00000261681 | + | 2 | 15 | 181_243 | 122 | 676 | LIN7C |
| Tgene | MPP5 | chr14:68035933 | chr14:67759228 | ENST00000555925 | + | 2 | 15 | 181_243 | 88 | 642 | LIN7C |
| - Lost PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
| Tgene | MPP5 | chr14:68035933 | chr14:67759228 | ENST00000261681 | + | 2 | 15 | 21_140 | 122 | 676 | PARD6B |
| Tgene | MPP5 | chr14:68035933 | chr14:67759228 | ENST00000555925 | + | 2 | 15 | 21_140 | 88 | 642 | PARD6B |
| - Retained PPIs, but lost function due to frame-shift fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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RelatedDrugs for PLEKHH1_MPP5 |
| Drugs targeting genes involved in this fusion gene. (DrugBank Version 5.1.0 2018-04-02) |
| Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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RelatedDiseases for PLEKHH1_MPP5 |
| Diseases associated with fusion partners. (DisGeNet 4.0) |
| Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
| Hgene | PLEKHH1 | C0023893 | Liver Cirrhosis, Experimental | 1 | CTD_human |
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