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Fusion gene ID: 27648 |
FusionGeneSummary for PLEKHH1_GPHN |
 Fusion gene summary |
| Fusion gene information | Fusion gene name: PLEKHH1_GPHN | Fusion gene ID: 27648 | Hgene | Tgene | Gene symbol | PLEKHH1 | GPHN | Gene ID | 57475 | 10243 |
| Gene name | pleckstrin homology, MyTH4 and FERM domain containing H1 | gephyrin | |
| Synonyms | - | GEPH|GPH|GPHRYN|HKPX1|MOCODC | |
| Cytomap | 14q24.1 | 14q23.3-q24.1 | |
| Type of gene | protein-coding | protein-coding | |
| Description | pleckstrin homology domain-containing family H member 1PH domain-containing family H member 1pleckstrin homology domain containing, family H (with MyTH4 domain) member 1 | gephyrin | |
| Modification date | 20180519 | 20180523 | |
| UniProtAcc | Q9ULM0 | Q9NQX3 | |
| Ensembl transtripts involved in fusion gene | ENST00000329153, ENST00000417684, ENST00000559832, | ENST00000315266, ENST00000478722, ENST00000459628, ENST00000543237, ENST00000305960, ENST00000544752, | |
| Fusion gene scores | * DoF score | 7 X 7 X 3=147 | 9 X 13 X 12=1404 |
| # samples | 8 | 20 | |
| ** MAII score | log2(8/147*10)=-0.877744249949002 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | log2(20/1404*10)=-2.81147103052984 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | |
| Context | PubMed: PLEKHH1 [Title/Abstract] AND GPHN [Title/Abstract] AND fusion [Title/Abstract] | ||
| Functional or gene categories assigned by FusionGDB annotation | |||
| * DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
| Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Partner | Gene | GO ID | GO term | PubMed ID |
| Tgene | GPHN | GO:0032324 | molybdopterin cofactor biosynthetic process | 26613940 |
| Tgene | GPHN | GO:0097112 | gamma-aminobutyric acid receptor clustering | 26613940 |
| Fusion gene information from three resources (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| TCGA | RV | BLCA | TCGA-K4-A3WV-01A | PLEKHH1 | chr14 | 68028752 | + | GPHN | chr14 | 67525366 | + |
| * LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
| Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| In-frame | ENST00000329153 | ENST00000315266 | PLEKHH1 | chr14 | 68028752 | + | GPHN | chr14 | 67525366 | + |
| In-frame | ENST00000329153 | ENST00000478722 | PLEKHH1 | chr14 | 68028752 | + | GPHN | chr14 | 67525366 | + |
| Frame-shift | ENST00000329153 | ENST00000459628 | PLEKHH1 | chr14 | 68028752 | + | GPHN | chr14 | 67525366 | + |
| In-frame | ENST00000329153 | ENST00000543237 | PLEKHH1 | chr14 | 68028752 | + | GPHN | chr14 | 67525366 | + |
| In-frame | ENST00000329153 | ENST00000305960 | PLEKHH1 | chr14 | 68028752 | + | GPHN | chr14 | 67525366 | + |
| 5CDS-3UTR | ENST00000329153 | ENST00000544752 | PLEKHH1 | chr14 | 68028752 | + | GPHN | chr14 | 67525366 | + |
| intron-3CDS | ENST00000417684 | ENST00000315266 | PLEKHH1 | chr14 | 68028752 | + | GPHN | chr14 | 67525366 | + |
| intron-3CDS | ENST00000417684 | ENST00000478722 | PLEKHH1 | chr14 | 68028752 | + | GPHN | chr14 | 67525366 | + |
| intron-3CDS | ENST00000417684 | ENST00000459628 | PLEKHH1 | chr14 | 68028752 | + | GPHN | chr14 | 67525366 | + |
| intron-3CDS | ENST00000417684 | ENST00000543237 | PLEKHH1 | chr14 | 68028752 | + | GPHN | chr14 | 67525366 | + |
| intron-3CDS | ENST00000417684 | ENST00000305960 | PLEKHH1 | chr14 | 68028752 | + | GPHN | chr14 | 67525366 | + |
| intron-3UTR | ENST00000417684 | ENST00000544752 | PLEKHH1 | chr14 | 68028752 | + | GPHN | chr14 | 67525366 | + |
| intron-3CDS | ENST00000559832 | ENST00000315266 | PLEKHH1 | chr14 | 68028752 | + | GPHN | chr14 | 67525366 | + |
| intron-3CDS | ENST00000559832 | ENST00000478722 | PLEKHH1 | chr14 | 68028752 | + | GPHN | chr14 | 67525366 | + |
| intron-3CDS | ENST00000559832 | ENST00000459628 | PLEKHH1 | chr14 | 68028752 | + | GPHN | chr14 | 67525366 | + |
| intron-3CDS | ENST00000559832 | ENST00000543237 | PLEKHH1 | chr14 | 68028752 | + | GPHN | chr14 | 67525366 | + |
| intron-3CDS | ENST00000559832 | ENST00000305960 | PLEKHH1 | chr14 | 68028752 | + | GPHN | chr14 | 67525366 | + |
| intron-3UTR | ENST00000559832 | ENST00000544752 | PLEKHH1 | chr14 | 68028752 | + | GPHN | chr14 | 67525366 | + |
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FusionProtFeatures for PLEKHH1_GPHN |
| Main function of each fusion partner protein. (from UniProt) |
| Hgene | Tgene |
| PLEKHH1 | GPHN |
| Microtubule-associated protein involved in membraneprotein-cytoskeleton interactions. It is thought to anchor theinhibitory glycine receptor (GLYR) to subsynaptic microtubules.Catalyzes two steps in the biosynthesis of the molybdenumcofactor. In the first step, molybdopterin is adenylated.Subsequently, molybdate is inserted into adenylated molybdopterinand AMP is released. {ECO:0000269|PubMed:26613940}. |
| Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at . * Minus value of BPloci means that the break pointn is located before the CDS. |
| - In-frame and retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
| Hgene | PLEKHH1 | chr14:68028752 | chr14:67525366 | ENST00000329153 | + | 6 | 29 | 28_169 | 168 | 1365 | Coiled coil | Ontology_term=ECO:0000255 |
| Tgene | >GPHN | chr14:68028752 | chr14:67525366 | ENST00000315266 | + | 8 | 22 | 326_736 | 302 | 737 | Region | Note=MPT adenylyltransferase |
| - In-frame and not-retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
| Hgene | >PLEKHH1 | chr14:68028752 | chr14:67525366 | ENST00000329153 | + | 6 | 29 | 239_242 | 168 | 1365 | Compositional bias | Note=Poly-Ser |
| Hgene | >PLEKHH1 | chr14:68028752 | chr14:67525366 | ENST00000329153 | + | 6 | 29 | 578_672 | 168 | 1365 | Domain | PH 1 |
| Hgene | >PLEKHH1 | chr14:68028752 | chr14:67525366 | ENST00000329153 | + | 6 | 29 | 687_796 | 168 | 1365 | Domain | PH 2 |
| Hgene | >PLEKHH1 | chr14:68028752 | chr14:67525366 | ENST00000329153 | + | 6 | 29 | 832_986 | 168 | 1365 | Domain | MyTH4 |
| Hgene | >PLEKHH1 | chr14:68028752 | chr14:67525366 | ENST00000329153 | + | 6 | 29 | 997_1333 | 168 | 1365 | Domain | FERM |
| Tgene | GPHN | chr14:68028752 | chr14:67525366 | ENST00000315266 | + | 8 | 22 | 14_166 | 302 | 737 | Region | Note=MPT Mo-transferase |
| Tgene | GPHN | chr14:68028752 | chr14:67525366 | ENST00000478722 | + | 9 | 23 | 14_166 | 335 | 770 | Region | Note=MPT Mo-transferase |
| Tgene | GPHN | chr14:68028752 | chr14:67525366 | ENST00000478722 | + | 9 | 23 | 326_736 | 335 | 770 | Region | Note=MPT adenylyltransferase |
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FusionGeneSequence for PLEKHH1_GPHN |
| For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. (nt: nucleotides, aa: amino acids) |
| * Fusion amino acid sequences. |
| >In-frame_PLEKHH1_ENST00000329153_chr14_68028752_+_GPHN_ENST00000315266_chr14_67525366_+_603aa MAELKVEAPASVDWQKRCLTLETQLFRFRLQASKIRELLADKMQELEQRLLEAEQRAENAETQVGVMEEKVKLSNLKNVDSEGSLHRKYQ ELLKAIKGKDELISQLEAQLEKQKQMRAEEAKTVQEKAAKIKEWVTLKLAKLEMENQHLKSHNQRLVEQVGSLQDALEGHSAVDITKVAR RHRMSPFPLTSMDKAFITVLEMTPVLGTEIINYRDGMGRVLAQDVYAKDNLPPFPASVKDGYAVRAADGPGDRFIIGESQAGEQPTQTVM PGQVMRVTTGAPIPCGADAVVQVEDTELIRESDDGTEELEVRILVQARPGQDIRPIGHDIKRGECVLAKGTHMGPSEIGLLATVGVTEVE VNKFPVVAVMSTGNELLNPEDDLLPGKIRDSNRSTLLATIQEHGYPTINLGIVGDNPDDLLNALNEGISRADVIITSGGVSMGEKDYLKQ VLDIDLHAQIHFGRVFMKPGLPTTFATLDIDGVRKIIFALPGNPVSAVVTCNLFVVPALRKMQGILDPRPTIIKARLSCDVKLDPRPEYH >In-frame_PLEKHH1_ENST00000329153_chr14_68028752_+_GPHN_ENST00000478722_chr14_67525366_+_603aa MAELKVEAPASVDWQKRCLTLETQLFRFRLQASKIRELLADKMQELEQRLLEAEQRAENAETQVGVMEEKVKLSNLKNVDSEGSLHRKYQ ELLKAIKGKDELISQLEAQLEKQKQMRAEEAKTVQEKAAKIKEWVTLKLAKLEMENQHLKSHNQRLVEQVGSLQDALEGHSAVDITKVAR RHRMSPFPLTSMDKAFITVLEMTPVLGTEIINYRDGMGRVLAQDVYAKDNLPPFPASVKDGYAVRAADGPGDRFIIGESQAGEQPTQTVM PGQVMRVTTGAPIPCGADAVVQVEDTELIRESDDGTEELEVRILVQARPGQDIRPIGHDIKRGECVLAKGTHMGPSEIGLLATVGVTEVE VNKFPVVAVMSTGNELLNPEDDLLPGKIRDSNRSTLLATIQEHGYPTINLGIVGDNPDDLLNALNEGISRADVIITSGGVSMGEKDYLKQ VLDIDLHAQIHFGRVFMKPGLPTTFATLDIDGVRKIIFALPGNPVSAVVTCNLFVVPALRKMQGILDPRPTIIKARLSCDVKLDPRPEYH >In-frame_PLEKHH1_ENST00000329153_chr14_68028752_+_GPHN_ENST00000543237_chr14_67525366_+_603aa MAELKVEAPASVDWQKRCLTLETQLFRFRLQASKIRELLADKMQELEQRLLEAEQRAENAETQVGVMEEKVKLSNLKNVDSEGSLHRKYQ ELLKAIKGKDELISQLEAQLEKQKQMRAEEAKTVQEKAAKIKEWVTLKLAKLEMENQHLKSHNQRLVEQVGSLQDALEGHSAVDITKVAR RHRMSPFPLTSMDKAFITVLEMTPVLGTEIINYRDGMGRVLAQDVYAKDNLPPFPASVKDGYAVRAADGPGDRFIIGESQAGEQPTQTVM PGQVMRVTTGAPIPCGADAVVQVEDTELIRESDDGTEELEVRILVQARPGQDIRPIGHDIKRGECVLAKGTHMGPSEIGLLATVGVTEVE VNKFPVVAVMSTGNELLNPEDDLLPGKIRDSNRSTLLATIQEHGYPTINLGIVGDNPDDLLNALNEGISRADVIITSGGVSMGEKDYLKQ VLDIDLHAQIHFGRVFMKPGLPTTFATLDIDGVRKIIFALPGNPVSAVVTCNLFVVPALRKMQGILDPRPTIIKARLSCDVKLDPRPEYH >In-frame_PLEKHH1_ENST00000329153_chr14_68028752_+_GPHN_ENST00000305960_chr14_67525366_+_603aa MAELKVEAPASVDWQKRCLTLETQLFRFRLQASKIRELLADKMQELEQRLLEAEQRAENAETQVGVMEEKVKLSNLKNVDSEGSLHRKYQ ELLKAIKGKDELISQLEAQLEKQKQMRAEEAKTVQEKAAKIKEWVTLKLAKLEMENQHLKSHNQRLVEQVGSLQDALEGHSAVDITKVAR RHRMSPFPLTSMDKAFITVLEMTPVLGTEIINYRDGMGRVLAQDVYAKDNLPPFPASVKDGYAVRAADGPGDRFIIGESQAGEQPTQTVM PGQVMRVTTGAPIPCGADAVVQVEDTELIRESDDGTEELEVRILVQARPGQDIRPIGHDIKRGECVLAKGTHMGPSEIGLLATVGVTEVE VNKFPVVAVMSTGNELLNPEDDLLPGKIRDSNRSTLLATIQEHGYPTINLGIVGDNPDDLLNALNEGISRADVIITSGGVSMGEKDYLKQ VLDIDLHAQIHFGRVFMKPGLPTTFATLDIDGVRKIIFALPGNPVSAVVTCNLFVVPALRKMQGILDPRPTIIKARLSCDVKLDPRPEYH |
| * Fusion transcript sequences (only coding sequence (CDS) region). |
| >In-frame_PLEKHH1_ENST00000329153_chr14_68028752_+_GPHN_ENST00000315266_chr14_67525366_+_1809nt ATGGCAGAACTCAAGGTGGAGGCGCCGGCCAGCGTAGACTGGCAGAAACGCTGCCTGACCCTGGAAACTCAGCTTTTCCGGTTCCGCCTA CAGGCCAGCAAGATAAGGGAGCTGCTGGCTGACAAGATGCAGGAGCTGGAGCAGAGGCTGCTGGAGGCAGAGCAGAGAGCAGAGAACGCT GAGACCCAGGTGGGTGTCATGGAAGAGAAGGTAAAACTATCCAATCTGAAGAATGTGGACTCTGAGGGGAGCCTGCACCGGAAATACCAA GAATTGCTGAAAGCCATAAAGGGCAAAGATGAGCTCATCAGCCAGCTAGAGGCTCAGCTGGAGAAGCAGAAGCAGATGAGGGCAGAGGAA GCAAAAACTGTTCAAGAAAAAGCTGCAAAGATCAAGGAATGGGTGACACTCAAGTTGGCAAAGCTTGAGATGGAGAATCAGCATCTGAAA AGCCATAATCAGCGCCTGGTGGAGCAGGTGGGATCCCTTCAAGATGCGCTAGAAGGTCACAGTGCTGTCGATATCACCAAGGTGGCTAGA AGACATCGCATGTCTCCTTTTCCTCTGACATCTATGGACAAAGCCTTTATCACAGTCCTGGAGATGACTCCGGTGCTTGGGACAGAAATC ATCAATTACCGAGATGGAATGGGGCGAGTCCTTGCTCAAGATGTATATGCAAAAGACAATTTACCCCCCTTCCCAGCATCAGTAAAAGAT GGCTATGCTGTCCGAGCTGCTGATGGCCCAGGAGATCGTTTCATCATTGGGGAATCCCAAGCTGGTGAACAGCCAACTCAGACAGTAATG CCAGGACAAGTCATGCGGGTTACAACAGGTGCTCCAATACCCTGCGGTGCTGATGCAGTAGTACAAGTGGAAGATACCGAACTTATCAGG GAATCAGATGATGGCACTGAAGAACTTGAAGTGCGAATTCTGGTGCAAGCTCGGCCAGGCCAAGATATCAGACCCATCGGCCATGACATT AAAAGAGGGGAATGTGTTTTGGCCAAAGGAACCCACATGGGCCCCTCAGAGATTGGTCTTCTGGCAACTGTAGGTGTCACAGAGGTTGAA GTTAATAAGTTTCCAGTGGTTGCAGTCATGTCAACAGGGAATGAGCTGCTAAATCCTGAAGATGACCTCTTACCAGGGAAGATTCGAGAC AGCAATCGTTCAACTCTTCTAGCAACAATTCAGGAACATGGTTACCCCACGATCAACTTGGGTATTGTAGGAGACAACCCAGATGACTTA CTCAATGCCTTGAATGAGGGTATCAGTCGTGCTGATGTCATCATCACATCAGGGGGTGTATCCATGGGGGAAAAGGACTATCTCAAGCAG GTGCTGGACATTGATCTTCATGCTCAGATCCATTTTGGCAGGGTTTTTATGAAACCAGGCTTGCCAACAACATTTGCAACTTTGGATATT GATGGTGTAAGAAAAATAATCTTTGCACTACCTGGGAATCCTGTATCGGCTGTGGTCACCTGCAATCTCTTTGTTGTGCCTGCACTGAGG AAAATGCAGGGCATCTTGGATCCTCGGCCAACCATCATCAAAGCAAGGTTATCATGTGATGTAAAACTTGATCCTCGTCCAGAATACCAT CGGTGTATACTAACTTGGCATCACCAAGAACCACTACCTTGGGCACAGAGTACAGGTAATCAAATGAGCAGCCGTCTGATGAGCATGCGC AGTGCCAATGGATTGTTGATGCTACCTCCAAAGACAGAACAGTACGTGGAGCTCCACAAAGGCGAGGTGGTGGATGTCATGGTCATTGGA >In-frame_PLEKHH1_ENST00000329153_chr14_68028752_+_GPHN_ENST00000478722_chr14_67525366_+_1809nt ATGGCAGAACTCAAGGTGGAGGCGCCGGCCAGCGTAGACTGGCAGAAACGCTGCCTGACCCTGGAAACTCAGCTTTTCCGGTTCCGCCTA CAGGCCAGCAAGATAAGGGAGCTGCTGGCTGACAAGATGCAGGAGCTGGAGCAGAGGCTGCTGGAGGCAGAGCAGAGAGCAGAGAACGCT GAGACCCAGGTGGGTGTCATGGAAGAGAAGGTAAAACTATCCAATCTGAAGAATGTGGACTCTGAGGGGAGCCTGCACCGGAAATACCAA GAATTGCTGAAAGCCATAAAGGGCAAAGATGAGCTCATCAGCCAGCTAGAGGCTCAGCTGGAGAAGCAGAAGCAGATGAGGGCAGAGGAA GCAAAAACTGTTCAAGAAAAAGCTGCAAAGATCAAGGAATGGGTGACACTCAAGTTGGCAAAGCTTGAGATGGAGAATCAGCATCTGAAA AGCCATAATCAGCGCCTGGTGGAGCAGGTGGGATCCCTTCAAGATGCGCTAGAAGGTCACAGTGCTGTCGATATCACCAAGGTGGCTAGA AGACATCGCATGTCTCCTTTTCCTCTGACATCTATGGACAAAGCCTTTATCACAGTCCTGGAGATGACTCCGGTGCTTGGGACAGAAATC ATCAATTACCGAGATGGAATGGGGCGAGTCCTTGCTCAAGATGTATATGCAAAAGACAATTTACCCCCCTTCCCAGCATCAGTAAAAGAT GGCTATGCTGTCCGAGCTGCTGATGGCCCAGGAGATCGTTTCATCATTGGGGAATCCCAAGCTGGTGAACAGCCAACTCAGACAGTAATG CCAGGACAAGTCATGCGGGTTACAACAGGTGCTCCAATACCCTGCGGTGCTGATGCAGTAGTACAAGTGGAAGATACCGAACTTATCAGG GAATCAGATGATGGCACTGAAGAACTTGAAGTGCGAATTCTGGTGCAAGCTCGGCCAGGCCAAGATATCAGACCCATCGGCCATGACATT AAAAGAGGGGAATGTGTTTTGGCCAAAGGAACCCACATGGGCCCCTCAGAGATTGGTCTTCTGGCAACTGTAGGTGTCACAGAGGTTGAA GTTAATAAGTTTCCAGTGGTTGCAGTCATGTCAACAGGGAATGAGCTGCTAAATCCTGAAGATGACCTCTTACCAGGGAAGATTCGAGAC AGCAATCGTTCAACTCTTCTAGCAACAATTCAGGAACATGGTTACCCCACGATCAACTTGGGTATTGTAGGAGACAACCCAGATGACTTA CTCAATGCCTTGAATGAGGGTATCAGTCGTGCTGATGTCATCATCACATCAGGGGGTGTATCCATGGGGGAAAAGGACTATCTCAAGCAG GTGCTGGACATTGATCTTCATGCTCAGATCCATTTTGGCAGGGTTTTTATGAAACCAGGCTTGCCAACAACATTTGCAACTTTGGATATT GATGGTGTAAGAAAAATAATCTTTGCACTACCTGGGAATCCTGTATCGGCTGTGGTCACCTGCAATCTCTTTGTTGTGCCTGCACTGAGG AAAATGCAGGGCATCTTGGATCCTCGGCCAACCATCATCAAAGCAAGGTTATCATGTGATGTAAAACTTGATCCTCGTCCAGAATACCAT CGGTGTATACTAACTTGGCATCACCAAGAACCACTACCTTGGGCACAGAGTACAGGTAATCAAATGAGCAGCCGTCTGATGAGCATGCGC AGTGCCAATGGATTGTTGATGCTACCTCCAAAGACAGAACAGTACGTGGAGCTCCACAAAGGCGAGGTGGTGGATGTCATGGTCATTGGA >In-frame_PLEKHH1_ENST00000329153_chr14_68028752_+_GPHN_ENST00000543237_chr14_67525366_+_1809nt ATGGCAGAACTCAAGGTGGAGGCGCCGGCCAGCGTAGACTGGCAGAAACGCTGCCTGACCCTGGAAACTCAGCTTTTCCGGTTCCGCCTA CAGGCCAGCAAGATAAGGGAGCTGCTGGCTGACAAGATGCAGGAGCTGGAGCAGAGGCTGCTGGAGGCAGAGCAGAGAGCAGAGAACGCT GAGACCCAGGTGGGTGTCATGGAAGAGAAGGTAAAACTATCCAATCTGAAGAATGTGGACTCTGAGGGGAGCCTGCACCGGAAATACCAA GAATTGCTGAAAGCCATAAAGGGCAAAGATGAGCTCATCAGCCAGCTAGAGGCTCAGCTGGAGAAGCAGAAGCAGATGAGGGCAGAGGAA GCAAAAACTGTTCAAGAAAAAGCTGCAAAGATCAAGGAATGGGTGACACTCAAGTTGGCAAAGCTTGAGATGGAGAATCAGCATCTGAAA AGCCATAATCAGCGCCTGGTGGAGCAGGTGGGATCCCTTCAAGATGCGCTAGAAGGTCACAGTGCTGTCGATATCACCAAGGTGGCTAGA AGACATCGCATGTCTCCTTTTCCTCTGACATCTATGGACAAAGCCTTTATCACAGTCCTGGAGATGACTCCGGTGCTTGGGACAGAAATC ATCAATTACCGAGATGGAATGGGGCGAGTCCTTGCTCAAGATGTATATGCAAAAGACAATTTACCCCCCTTCCCAGCATCAGTAAAAGAT GGCTATGCTGTCCGAGCTGCTGATGGCCCAGGAGATCGTTTCATCATTGGGGAATCCCAAGCTGGTGAACAGCCAACTCAGACAGTAATG CCAGGACAAGTCATGCGGGTTACAACAGGTGCTCCAATACCCTGCGGTGCTGATGCAGTAGTACAAGTGGAAGATACCGAACTTATCAGG GAATCAGATGATGGCACTGAAGAACTTGAAGTGCGAATTCTGGTGCAAGCTCGGCCAGGCCAAGATATCAGACCCATCGGCCATGACATT AAAAGAGGGGAATGTGTTTTGGCCAAAGGAACCCACATGGGCCCCTCAGAGATTGGTCTTCTGGCAACTGTAGGTGTCACAGAGGTTGAA GTTAATAAGTTTCCAGTGGTTGCAGTCATGTCAACAGGGAATGAGCTGCTAAATCCTGAAGATGACCTCTTACCAGGGAAGATTCGAGAC AGCAATCGTTCAACTCTTCTAGCAACAATTCAGGAACATGGTTACCCCACGATCAACTTGGGTATTGTAGGAGACAACCCAGATGACTTA CTCAATGCCTTGAATGAGGGTATCAGTCGTGCTGATGTCATCATCACATCAGGGGGTGTATCCATGGGGGAAAAGGACTATCTCAAGCAG GTGCTGGACATTGATCTTCATGCTCAGATCCATTTTGGCAGGGTTTTTATGAAACCAGGCTTGCCAACAACATTTGCAACTTTGGATATT GATGGTGTAAGAAAAATAATCTTTGCACTACCTGGGAATCCTGTATCGGCTGTGGTCACCTGCAATCTCTTTGTTGTGCCTGCACTGAGG AAAATGCAGGGCATCTTGGATCCTCGGCCAACCATCATCAAAGCAAGGTTATCATGTGATGTAAAACTTGATCCTCGTCCAGAATACCAT CGGTGTATACTAACTTGGCATCACCAAGAACCACTACCTTGGGCACAGAGTACAGGTAATCAAATGAGCAGCCGTCTGATGAGCATGCGC AGTGCCAATGGATTGTTGATGCTACCTCCAAAGACAGAACAGTACGTGGAGCTCCACAAAGGCGAGGTGGTGGATGTCATGGTCATTGGA >In-frame_PLEKHH1_ENST00000329153_chr14_68028752_+_GPHN_ENST00000305960_chr14_67525366_+_1809nt ATGGCAGAACTCAAGGTGGAGGCGCCGGCCAGCGTAGACTGGCAGAAACGCTGCCTGACCCTGGAAACTCAGCTTTTCCGGTTCCGCCTA CAGGCCAGCAAGATAAGGGAGCTGCTGGCTGACAAGATGCAGGAGCTGGAGCAGAGGCTGCTGGAGGCAGAGCAGAGAGCAGAGAACGCT GAGACCCAGGTGGGTGTCATGGAAGAGAAGGTAAAACTATCCAATCTGAAGAATGTGGACTCTGAGGGGAGCCTGCACCGGAAATACCAA GAATTGCTGAAAGCCATAAAGGGCAAAGATGAGCTCATCAGCCAGCTAGAGGCTCAGCTGGAGAAGCAGAAGCAGATGAGGGCAGAGGAA GCAAAAACTGTTCAAGAAAAAGCTGCAAAGATCAAGGAATGGGTGACACTCAAGTTGGCAAAGCTTGAGATGGAGAATCAGCATCTGAAA AGCCATAATCAGCGCCTGGTGGAGCAGGTGGGATCCCTTCAAGATGCGCTAGAAGGTCACAGTGCTGTCGATATCACCAAGGTGGCTAGA AGACATCGCATGTCTCCTTTTCCTCTGACATCTATGGACAAAGCCTTTATCACAGTCCTGGAGATGACTCCGGTGCTTGGGACAGAAATC ATCAATTACCGAGATGGAATGGGGCGAGTCCTTGCTCAAGATGTATATGCAAAAGACAATTTACCCCCCTTCCCAGCATCAGTAAAAGAT GGCTATGCTGTCCGAGCTGCTGATGGCCCAGGAGATCGTTTCATCATTGGGGAATCCCAAGCTGGTGAACAGCCAACTCAGACAGTAATG CCAGGACAAGTCATGCGGGTTACAACAGGTGCTCCAATACCCTGCGGTGCTGATGCAGTAGTACAAGTGGAAGATACCGAACTTATCAGG GAATCAGATGATGGCACTGAAGAACTTGAAGTGCGAATTCTGGTGCAAGCTCGGCCAGGCCAAGATATCAGACCCATCGGCCATGACATT AAAAGAGGGGAATGTGTTTTGGCCAAAGGAACCCACATGGGCCCCTCAGAGATTGGTCTTCTGGCAACTGTAGGTGTCACAGAGGTTGAA GTTAATAAGTTTCCAGTGGTTGCAGTCATGTCAACAGGGAATGAGCTGCTAAATCCTGAAGATGACCTCTTACCAGGGAAGATTCGAGAC AGCAATCGTTCAACTCTTCTAGCAACAATTCAGGAACATGGTTACCCCACGATCAACTTGGGTATTGTAGGAGACAACCCAGATGACTTA CTCAATGCCTTGAATGAGGGTATCAGTCGTGCTGATGTCATCATCACATCAGGGGGTGTATCCATGGGGGAAAAGGACTATCTCAAGCAG GTGCTGGACATTGATCTTCATGCTCAGATCCATTTTGGCAGGGTTTTTATGAAACCAGGCTTGCCAACAACATTTGCAACTTTGGATATT GATGGTGTAAGAAAAATAATCTTTGCACTACCTGGGAATCCTGTATCGGCTGTGGTCACCTGCAATCTCTTTGTTGTGCCTGCACTGAGG AAAATGCAGGGCATCTTGGATCCTCGGCCAACCATCATCAAAGCAAGGTTATCATGTGATGTAAAACTTGATCCTCGTCCAGAATACCAT CGGTGTATACTAACTTGGCATCACCAAGAACCACTACCTTGGGCACAGAGTACAGGTAATCAAATGAGCAGCCGTCTGATGAGCATGCGC AGTGCCAATGGATTGTTGATGCTACCTCCAAAGACAGAACAGTACGTGGAGCTCCACAAAGGCGAGGTGGTGGATGTCATGGTCATTGGA |
| * Fusion transcript sequences (Full-length transcript). |
| >In-frame_PLEKHH1_ENST00000329153_chr14_68028752_+_GPHN_ENST00000315266_chr14_67525366_+_2802nt GGGACTCCGGCGAGAGCGACGCAAGGTCGGCTGCGGCGGCGGCCCGAGGGCGCCCGTGTGCCCAGTGCGCGGCGGGGACGGCCGCGAGCT CGCTGGAGGGCTCCCCAGAATAATCCAGAAGTCGATTCCATCATGGCAGAACTCAAGGTGGAGGCGCCGGCCAGCGTAGACTGGCAGAAA CGCTGCCTGACCCTGGAAACTCAGCTTTTCCGGTTCCGCCTACAGGCCAGCAAGATAAGGGAGCTGCTGGCTGACAAGATGCAGGAGCTG GAGCAGAGGCTGCTGGAGGCAGAGCAGAGAGCAGAGAACGCTGAGACCCAGGTGGGTGTCATGGAAGAGAAGGTAAAACTATCCAATCTG AAGAATGTGGACTCTGAGGGGAGCCTGCACCGGAAATACCAAGAATTGCTGAAAGCCATAAAGGGCAAAGATGAGCTCATCAGCCAGCTA GAGGCTCAGCTGGAGAAGCAGAAGCAGATGAGGGCAGAGGAAGCAAAAACTGTTCAAGAAAAAGCTGCAAAGATCAAGGAATGGGTGACA CTCAAGTTGGCAAAGCTTGAGATGGAGAATCAGCATCTGAAAAGCCATAATCAGCGCCTGGTGGAGCAGGTGGGATCCCTTCAAGATGCG CTAGAAGGTCACAGTGCTGTCGATATCACCAAGGTGGCTAGAAGACATCGCATGTCTCCTTTTCCTCTGACATCTATGGACAAAGCCTTT ATCACAGTCCTGGAGATGACTCCGGTGCTTGGGACAGAAATCATCAATTACCGAGATGGAATGGGGCGAGTCCTTGCTCAAGATGTATAT GCAAAAGACAATTTACCCCCCTTCCCAGCATCAGTAAAAGATGGCTATGCTGTCCGAGCTGCTGATGGCCCAGGAGATCGTTTCATCATT GGGGAATCCCAAGCTGGTGAACAGCCAACTCAGACAGTAATGCCAGGACAAGTCATGCGGGTTACAACAGGTGCTCCAATACCCTGCGGT GCTGATGCAGTAGTACAAGTGGAAGATACCGAACTTATCAGGGAATCAGATGATGGCACTGAAGAACTTGAAGTGCGAATTCTGGTGCAA GCTCGGCCAGGCCAAGATATCAGACCCATCGGCCATGACATTAAAAGAGGGGAATGTGTTTTGGCCAAAGGAACCCACATGGGCCCCTCA GAGATTGGTCTTCTGGCAACTGTAGGTGTCACAGAGGTTGAAGTTAATAAGTTTCCAGTGGTTGCAGTCATGTCAACAGGGAATGAGCTG CTAAATCCTGAAGATGACCTCTTACCAGGGAAGATTCGAGACAGCAATCGTTCAACTCTTCTAGCAACAATTCAGGAACATGGTTACCCC ACGATCAACTTGGGTATTGTAGGAGACAACCCAGATGACTTACTCAATGCCTTGAATGAGGGTATCAGTCGTGCTGATGTCATCATCACA TCAGGGGGTGTATCCATGGGGGAAAAGGACTATCTCAAGCAGGTGCTGGACATTGATCTTCATGCTCAGATCCATTTTGGCAGGGTTTTT ATGAAACCAGGCTTGCCAACAACATTTGCAACTTTGGATATTGATGGTGTAAGAAAAATAATCTTTGCACTACCTGGGAATCCTGTATCG GCTGTGGTCACCTGCAATCTCTTTGTTGTGCCTGCACTGAGGAAAATGCAGGGCATCTTGGATCCTCGGCCAACCATCATCAAAGCAAGG TTATCATGTGATGTAAAACTTGATCCTCGTCCAGAATACCATCGGTGTATACTAACTTGGCATCACCAAGAACCACTACCTTGGGCACAG AGTACAGGTAATCAAATGAGCAGCCGTCTGATGAGCATGCGCAGTGCCAATGGATTGTTGATGCTACCTCCAAAGACAGAACAGTACGTG GAGCTCCACAAAGGCGAGGTGGTGGATGTCATGGTCATTGGACGGCTATGATGGTCACCAGCAGGAGAAAGCTTTGATGCATGTCCACAT ATCATTGACTGTATCCTGTAATATGCAACGGCACAGCTAGTTTTCCCGATTTGGATAAAAGTTGATCTGTATAGTCAACATCTTGAACTA TATTTCAAATGAATTTAAATATCTTTTAAAGAAAAAAACACCTAAAAATAAATCTTAACAGAAAATTCTGTTCTGATTATATCAAGGCAA ATTTTTCCTTTCTTGCAAATTGCTTTGTGTGTTCAATGCTAGGTCTGATAGCGATAGCTTTTAGTAGACAGCGGTAGGTGCCTGCAGAAC TTGTGTTTTTCTCATCTTTAAAATACAACTACTTATGCTCTTAAATCAAGGCTGTCTGCTTATTTATACTAGCGTAGGCAACACTTGGAT TTCCCTTCTTAGTATGCTTCATAACTGCTTTACAGAGAGCTTTTGCTTGTTCTTTCTCATGTATCTCGTGTTTATGTGCACAGTGCCAAA AGAAGACTGACTGGGTGGAGGCTCTGCCTTGCCTCAAGAACCATCCCCTGCAGAGCATCCAGGGAGGTTTCTCGCCCCAATAGCCTCACG GCACAGTACTCTTGGGCAGTAACTGGACACCTTTTATTTGAAGAAACAAACTGAAGAAAAAATGCTTCCTTAAGTGCTGACAGCCTTTTT AACCAATACATTTAAAATTGTACAGAACAAAAAAATAAAATCAAAGACTGATCTTGTACAGATATTAGTGTTACCAGCATTCATGTGGAA ATCAAGAGCAAAGACAAAATAATGTTAAACAATTCTGTACCATAACATTTTCTGTAATGATACTGAAACTTAATGAATAAAAAAATTCCT >In-frame_PLEKHH1_ENST00000329153_chr14_68028752_+_GPHN_ENST00000478722_chr14_67525366_+_2807nt GGGACTCCGGCGAGAGCGACGCAAGGTCGGCTGCGGCGGCGGCCCGAGGGCGCCCGTGTGCCCAGTGCGCGGCGGGGACGGCCGCGAGCT CGCTGGAGGGCTCCCCAGAATAATCCAGAAGTCGATTCCATCATGGCAGAACTCAAGGTGGAGGCGCCGGCCAGCGTAGACTGGCAGAAA CGCTGCCTGACCCTGGAAACTCAGCTTTTCCGGTTCCGCCTACAGGCCAGCAAGATAAGGGAGCTGCTGGCTGACAAGATGCAGGAGCTG GAGCAGAGGCTGCTGGAGGCAGAGCAGAGAGCAGAGAACGCTGAGACCCAGGTGGGTGTCATGGAAGAGAAGGTAAAACTATCCAATCTG AAGAATGTGGACTCTGAGGGGAGCCTGCACCGGAAATACCAAGAATTGCTGAAAGCCATAAAGGGCAAAGATGAGCTCATCAGCCAGCTA GAGGCTCAGCTGGAGAAGCAGAAGCAGATGAGGGCAGAGGAAGCAAAAACTGTTCAAGAAAAAGCTGCAAAGATCAAGGAATGGGTGACA CTCAAGTTGGCAAAGCTTGAGATGGAGAATCAGCATCTGAAAAGCCATAATCAGCGCCTGGTGGAGCAGGTGGGATCCCTTCAAGATGCG CTAGAAGGTCACAGTGCTGTCGATATCACCAAGGTGGCTAGAAGACATCGCATGTCTCCTTTTCCTCTGACATCTATGGACAAAGCCTTT ATCACAGTCCTGGAGATGACTCCGGTGCTTGGGACAGAAATCATCAATTACCGAGATGGAATGGGGCGAGTCCTTGCTCAAGATGTATAT GCAAAAGACAATTTACCCCCCTTCCCAGCATCAGTAAAAGATGGCTATGCTGTCCGAGCTGCTGATGGCCCAGGAGATCGTTTCATCATT GGGGAATCCCAAGCTGGTGAACAGCCAACTCAGACAGTAATGCCAGGACAAGTCATGCGGGTTACAACAGGTGCTCCAATACCCTGCGGT GCTGATGCAGTAGTACAAGTGGAAGATACCGAACTTATCAGGGAATCAGATGATGGCACTGAAGAACTTGAAGTGCGAATTCTGGTGCAA GCTCGGCCAGGCCAAGATATCAGACCCATCGGCCATGACATTAAAAGAGGGGAATGTGTTTTGGCCAAAGGAACCCACATGGGCCCCTCA GAGATTGGTCTTCTGGCAACTGTAGGTGTCACAGAGGTTGAAGTTAATAAGTTTCCAGTGGTTGCAGTCATGTCAACAGGGAATGAGCTG CTAAATCCTGAAGATGACCTCTTACCAGGGAAGATTCGAGACAGCAATCGTTCAACTCTTCTAGCAACAATTCAGGAACATGGTTACCCC ACGATCAACTTGGGTATTGTAGGAGACAACCCAGATGACTTACTCAATGCCTTGAATGAGGGTATCAGTCGTGCTGATGTCATCATCACA TCAGGGGGTGTATCCATGGGGGAAAAGGACTATCTCAAGCAGGTGCTGGACATTGATCTTCATGCTCAGATCCATTTTGGCAGGGTTTTT ATGAAACCAGGCTTGCCAACAACATTTGCAACTTTGGATATTGATGGTGTAAGAAAAATAATCTTTGCACTACCTGGGAATCCTGTATCG GCTGTGGTCACCTGCAATCTCTTTGTTGTGCCTGCACTGAGGAAAATGCAGGGCATCTTGGATCCTCGGCCAACCATCATCAAAGCAAGG TTATCATGTGATGTAAAACTTGATCCTCGTCCAGAATACCATCGGTGTATACTAACTTGGCATCACCAAGAACCACTACCTTGGGCACAG AGTACAGGTAATCAAATGAGCAGCCGTCTGATGAGCATGCGCAGTGCCAATGGATTGTTGATGCTACCTCCAAAGACAGAACAGTACGTG GAGCTCCACAAAGGCGAGGTGGTGGATGTCATGGTCATTGGACGGCTATGATGGTCACCAGCAGGAGAAAGCTTTGATGCATGTCCACAT ATCATTGACTGTATCCTGTAATATGCAACGGCACAGCTAGTTTTCCCGATTTGGATAAAAGTTGATCTGTATAGTCAACATCTTGAACTA TATTTCAAATGAATTTAAATATCTTTTAAAGAAAAAAACACCTAAAAATAAATCTTAACAGAAAATTCTGTTCTGATTATATCAAGGCAA ATTTTTCCTTTCTTGCAAATTGCTTTGTGTGTTCAATGCTAGGTCTGATAGCGATAGCTTTTAGTAGACAGCGGTAGGTGCCTGCAGAAC TTGTGTTTTTCTCATCTTTAAAATACAACTACTTATGCTCTTAAATCAAGGCTGTCTGCTTATTTATACTAGCGTAGGCAACACTTGGAT TTCCCTTCTTAGTATGCTTCATAACTGCTTTACAGAGAGCTTTTGCTTGTTCTTTCTCATGTATCTCGTGTTTATGTGCACAGTGCCAAA AGAAGACTGACTGGGTGGAGGCTCTGCCTTGCCTCAAGAACCATCCCCTGCAGAGCATCCAGGGAGGTTTCTCGCCCCAATAGCCTCACG GCACAGTACTCTTGGGCAGTAACTGGACACCTTTTATTTGAAGAAACAAACTGAAGAAAAAATGCTTCCTTAAGTGCTGACAGCCTTTTT AACCAATACATTTAAAATTGTACAGAACAAAAAAATAAAATCAAAGACTGATCTTGTACAGATATTAGTGTTACCAGCATTCATGTGGAA ATCAAGAGCAAAGACAAAATAATGTTAAACAATTCTGTACCATAACATTTTCTGTAATGATACTGAAACTTAATGAATAAAAAAATTCCT >In-frame_PLEKHH1_ENST00000329153_chr14_68028752_+_GPHN_ENST00000543237_chr14_67525366_+_2027nt GGGACTCCGGCGAGAGCGACGCAAGGTCGGCTGCGGCGGCGGCCCGAGGGCGCCCGTGTGCCCAGTGCGCGGCGGGGACGGCCGCGAGCT CGCTGGAGGGCTCCCCAGAATAATCCAGAAGTCGATTCCATCATGGCAGAACTCAAGGTGGAGGCGCCGGCCAGCGTAGACTGGCAGAAA CGCTGCCTGACCCTGGAAACTCAGCTTTTCCGGTTCCGCCTACAGGCCAGCAAGATAAGGGAGCTGCTGGCTGACAAGATGCAGGAGCTG GAGCAGAGGCTGCTGGAGGCAGAGCAGAGAGCAGAGAACGCTGAGACCCAGGTGGGTGTCATGGAAGAGAAGGTAAAACTATCCAATCTG AAGAATGTGGACTCTGAGGGGAGCCTGCACCGGAAATACCAAGAATTGCTGAAAGCCATAAAGGGCAAAGATGAGCTCATCAGCCAGCTA GAGGCTCAGCTGGAGAAGCAGAAGCAGATGAGGGCAGAGGAAGCAAAAACTGTTCAAGAAAAAGCTGCAAAGATCAAGGAATGGGTGACA CTCAAGTTGGCAAAGCTTGAGATGGAGAATCAGCATCTGAAAAGCCATAATCAGCGCCTGGTGGAGCAGGTGGGATCCCTTCAAGATGCG CTAGAAGGTCACAGTGCTGTCGATATCACCAAGGTGGCTAGAAGACATCGCATGTCTCCTTTTCCTCTGACATCTATGGACAAAGCCTTT ATCACAGTCCTGGAGATGACTCCGGTGCTTGGGACAGAAATCATCAATTACCGAGATGGAATGGGGCGAGTCCTTGCTCAAGATGTATAT GCAAAAGACAATTTACCCCCCTTCCCAGCATCAGTAAAAGATGGCTATGCTGTCCGAGCTGCTGATGGCCCAGGAGATCGTTTCATCATT GGGGAATCCCAAGCTGGTGAACAGCCAACTCAGACAGTAATGCCAGGACAAGTCATGCGGGTTACAACAGGTGCTCCAATACCCTGCGGT GCTGATGCAGTAGTACAAGTGGAAGATACCGAACTTATCAGGGAATCAGATGATGGCACTGAAGAACTTGAAGTGCGAATTCTGGTGCAA GCTCGGCCAGGCCAAGATATCAGACCCATCGGCCATGACATTAAAAGAGGGGAATGTGTTTTGGCCAAAGGAACCCACATGGGCCCCTCA GAGATTGGTCTTCTGGCAACTGTAGGTGTCACAGAGGTTGAAGTTAATAAGTTTCCAGTGGTTGCAGTCATGTCAACAGGGAATGAGCTG CTAAATCCTGAAGATGACCTCTTACCAGGGAAGATTCGAGACAGCAATCGTTCAACTCTTCTAGCAACAATTCAGGAACATGGTTACCCC ACGATCAACTTGGGTATTGTAGGAGACAACCCAGATGACTTACTCAATGCCTTGAATGAGGGTATCAGTCGTGCTGATGTCATCATCACA TCAGGGGGTGTATCCATGGGGGAAAAGGACTATCTCAAGCAGGTGCTGGACATTGATCTTCATGCTCAGATCCATTTTGGCAGGGTTTTT ATGAAACCAGGCTTGCCAACAACATTTGCAACTTTGGATATTGATGGTGTAAGAAAAATAATCTTTGCACTACCTGGGAATCCTGTATCG GCTGTGGTCACCTGCAATCTCTTTGTTGTGCCTGCACTGAGGAAAATGCAGGGCATCTTGGATCCTCGGCCAACCATCATCAAAGCAAGG TTATCATGTGATGTAAAACTTGATCCTCGTCCAGAATACCATCGGTGTATACTAACTTGGCATCACCAAGAACCACTACCTTGGGCACAG AGTACAGGTAATCAAATGAGCAGCCGTCTGATGAGCATGCGCAGTGCCAATGGATTGTTGATGCTACCTCCAAAGACAGAACAGTACGTG GAGCTCCACAAAGGCGAGGTGGTGGATGTCATGGTCATTGGACGGCTATGATGGTCACCAGCAGGAGAAAGCTTTGATGCATGTCCACAT >In-frame_PLEKHH1_ENST00000329153_chr14_68028752_+_GPHN_ENST00000305960_chr14_67525366_+_2201nt GGGACTCCGGCGAGAGCGACGCAAGGTCGGCTGCGGCGGCGGCCCGAGGGCGCCCGTGTGCCCAGTGCGCGGCGGGGACGGCCGCGAGCT CGCTGGAGGGCTCCCCAGAATAATCCAGAAGTCGATTCCATCATGGCAGAACTCAAGGTGGAGGCGCCGGCCAGCGTAGACTGGCAGAAA CGCTGCCTGACCCTGGAAACTCAGCTTTTCCGGTTCCGCCTACAGGCCAGCAAGATAAGGGAGCTGCTGGCTGACAAGATGCAGGAGCTG GAGCAGAGGCTGCTGGAGGCAGAGCAGAGAGCAGAGAACGCTGAGACCCAGGTGGGTGTCATGGAAGAGAAGGTAAAACTATCCAATCTG AAGAATGTGGACTCTGAGGGGAGCCTGCACCGGAAATACCAAGAATTGCTGAAAGCCATAAAGGGCAAAGATGAGCTCATCAGCCAGCTA GAGGCTCAGCTGGAGAAGCAGAAGCAGATGAGGGCAGAGGAAGCAAAAACTGTTCAAGAAAAAGCTGCAAAGATCAAGGAATGGGTGACA CTCAAGTTGGCAAAGCTTGAGATGGAGAATCAGCATCTGAAAAGCCATAATCAGCGCCTGGTGGAGCAGGTGGGATCCCTTCAAGATGCG CTAGAAGGTCACAGTGCTGTCGATATCACCAAGGTGGCTAGAAGACATCGCATGTCTCCTTTTCCTCTGACATCTATGGACAAAGCCTTT ATCACAGTCCTGGAGATGACTCCGGTGCTTGGGACAGAAATCATCAATTACCGAGATGGAATGGGGCGAGTCCTTGCTCAAGATGTATAT GCAAAAGACAATTTACCCCCCTTCCCAGCATCAGTAAAAGATGGCTATGCTGTCCGAGCTGCTGATGGCCCAGGAGATCGTTTCATCATT GGGGAATCCCAAGCTGGTGAACAGCCAACTCAGACAGTAATGCCAGGACAAGTCATGCGGGTTACAACAGGTGCTCCAATACCCTGCGGT GCTGATGCAGTAGTACAAGTGGAAGATACCGAACTTATCAGGGAATCAGATGATGGCACTGAAGAACTTGAAGTGCGAATTCTGGTGCAA GCTCGGCCAGGCCAAGATATCAGACCCATCGGCCATGACATTAAAAGAGGGGAATGTGTTTTGGCCAAAGGAACCCACATGGGCCCCTCA GAGATTGGTCTTCTGGCAACTGTAGGTGTCACAGAGGTTGAAGTTAATAAGTTTCCAGTGGTTGCAGTCATGTCAACAGGGAATGAGCTG CTAAATCCTGAAGATGACCTCTTACCAGGGAAGATTCGAGACAGCAATCGTTCAACTCTTCTAGCAACAATTCAGGAACATGGTTACCCC ACGATCAACTTGGGTATTGTAGGAGACAACCCAGATGACTTACTCAATGCCTTGAATGAGGGTATCAGTCGTGCTGATGTCATCATCACA TCAGGGGGTGTATCCATGGGGGAAAAGGACTATCTCAAGCAGGTGCTGGACATTGATCTTCATGCTCAGATCCATTTTGGCAGGGTTTTT ATGAAACCAGGCTTGCCAACAACATTTGCAACTTTGGATATTGATGGTGTAAGAAAAATAATCTTTGCACTACCTGGGAATCCTGTATCG GCTGTGGTCACCTGCAATCTCTTTGTTGTGCCTGCACTGAGGAAAATGCAGGGCATCTTGGATCCTCGGCCAACCATCATCAAAGCAAGG TTATCATGTGATGTAAAACTTGATCCTCGTCCAGAATACCATCGGTGTATACTAACTTGGCATCACCAAGAACCACTACCTTGGGCACAG AGTACAGGTAATCAAATGAGCAGCCGTCTGATGAGCATGCGCAGTGCCAATGGATTGTTGATGCTACCTCCAAAGACAGAACAGTACGTG GAGCTCCACAAAGGCGAGGTGGTGGATGTCATGGTCATTGGACGGCTATGATGGTCACCAGCAGGAGAAAGCTTTGATGCATGTCCACAT ATCATTGACTGTATCCTGTAATATGCAACGGCACAGCTAGTTTTCCCGATTTGGATAAAAGTTGATCTGTATAGTCAACATCTTGAACTA TATTTCAAATGAATTTAAATATCTTTTAAAGAAAAAAACACCTAAAAATAAATCTTAACAGAAAATTCTGTTCTGATTATATCAAGGCAA |
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FusionGenePPI for PLEKHH1_GPHN |
| Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in . |
| Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160) |
| Hgene | Hgene's interactors | Tgene | Tgene's interactors |
| PLEKHH1 | APBB1IP, LPXN | GPHN | ARHGEF9, GLRB, MTOR, PFN1, OTUD4, PRPF4, PCK1, SPATS1, GPHN, KHDRBS1, ACADVL, BRCC3, MTA2, PAAF1, PPP4R1, ROCK2, SPTAN1, TSSK1B, ODF3L2, NTRK1, DYNLL1, CDCA5, TCF4, SENP3, VASP, ENAH, KLKB1, KMO, LGALS3BP, STS, DYNLL2 |
| - Retained PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
| - Lost PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
| Tgene | GPHN | chr14:68028752 | chr14:67525366 | ENST00000315266 | + | 8 | 22 | 140_316 | 302 | 737 | GABARAP |
| Tgene | GPHN | chr14:68028752 | chr14:67525366 | ENST00000478722 | + | 9 | 23 | 140_316 | 335 | 770 | GABARAP |
| - Retained PPIs, but lost function due to frame-shift fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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RelatedDrugs for PLEKHH1_GPHN |
| Drugs targeting genes involved in this fusion gene. (DrugBank Version 5.1.0 2018-04-02) |
| Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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RelatedDiseases for PLEKHH1_GPHN |
| Diseases associated with fusion partners. (DisGeNet 4.0) |
| Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
| Hgene | PLEKHH1 | C0023893 | Liver Cirrhosis, Experimental | 1 | CTD_human |
| Tgene | GPHN | C0001973 | Alcoholic Intoxication, Chronic | 1 | CTD_human |
| Tgene | GPHN | C0236736 | Cocaine-Related Disorders | 1 | CTD_human |
| Tgene | GPHN | C1854990 | Molybdenum Cofactor Deficiency, Complementation Group C | 1 | ORPHANET;UNIPROT |
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