|
||||||
|
 | |
| |
| |
| |
| |
|
Fusion gene ID: 27607 |
FusionGeneSummary for PLEKHA7_MMP9 |
 Fusion gene summary |
| Fusion gene information | Fusion gene name: PLEKHA7_MMP9 | Fusion gene ID: 27607 | Hgene | Tgene | Gene symbol | PLEKHA7 | MMP9 | Gene ID | 144100 | 4318 |
| Gene name | pleckstrin homology domain containing A7 | matrix metallopeptidase 9 | |
| Synonyms | - | CLG4B|GELB|MANDP2|MMP-9 | |
| Cytomap | 11p15.2-p15.1 | 20q13.12 | |
| Type of gene | protein-coding | protein-coding | |
| Description | pleckstrin homology domain-containing family A member 7PH domain-containing family A member 7pleckstrin homology domain containing, family A member 2pleckstrin homology domain containing, family A member 7pleckstrin homology domain-containing family A | matrix metalloproteinase-9macrophage gelatinasematrix metallopeptidase 9 (gelatinase B, 92kDa gelatinase, 92kDa type IV collagenase)matrix metalloproteinase 9 (gelatinase B, 92kDa gelatinase, 92kDa type IV collagenase)type V collagenase | |
| Modification date | 20180522 | 20180527 | |
| UniProtAcc | Q6IQ23 | P14780 | |
| Ensembl transtripts involved in fusion gene | ENST00000531066, ENST00000355661, ENST00000448080, ENST00000532079, ENST00000332954, | ENST00000372330, | |
| Fusion gene scores | * DoF score | 8 X 3 X 7=168 | 5 X 4 X 5=100 |
| # samples | 8 | 5 | |
| ** MAII score | log2(8/168*10)=-1.0703893278914 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | log2(5/100*10)=-1 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | |
| Context | PubMed: PLEKHA7 [Title/Abstract] AND MMP9 [Title/Abstract] AND fusion [Title/Abstract] | ||
| Functional or gene categories assigned by FusionGDB annotation | |||
| * DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
| Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Partner | Gene | GO ID | GO term | PubMed ID |
| Tgene | MMP9 | GO:0006508 | proteolysis | 2551898|15863497|19022250|24164424 |
| Tgene | MMP9 | GO:0034614 | cellular response to reactive oxygen species | 26514923 |
| Tgene | MMP9 | GO:0043388 | positive regulation of DNA binding | 22984561 |
| Tgene | MMP9 | GO:0071276 | cellular response to cadmium ion | 26514923 |
| Tgene | MMP9 | GO:1900122 | positive regulation of receptor binding | 24164424 |
| Tgene | MMP9 | GO:2001258 | negative regulation of cation channel activity | 24164424 |
| Fusion gene information from three resources (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| TCGA | RV | PRAD | TCGA-EJ-7785-01A | PLEKHA7 | chr11 | 16872738 | - | MMP9 | chr20 | 44638505 | + |
| * LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
| Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| In-frame | ENST00000531066 | ENST00000372330 | PLEKHA7 | chr11 | 16872738 | - | MMP9 | chr20 | 44638505 | + |
| In-frame | ENST00000355661 | ENST00000372330 | PLEKHA7 | chr11 | 16872738 | - | MMP9 | chr20 | 44638505 | + |
| In-frame | ENST00000448080 | ENST00000372330 | PLEKHA7 | chr11 | 16872738 | - | MMP9 | chr20 | 44638505 | + |
| intron-3CDS | ENST00000532079 | ENST00000372330 | PLEKHA7 | chr11 | 16872738 | - | MMP9 | chr20 | 44638505 | + |
| intron-3CDS | ENST00000332954 | ENST00000372330 | PLEKHA7 | chr11 | 16872738 | - | MMP9 | chr20 | 44638505 | + |
Top |
FusionProtFeatures for PLEKHA7_MMP9 |
| Main function of each fusion partner protein. (from UniProt) |
| Hgene | Tgene |
| PLEKHA7 | MMP9 |
| Required for zonula adherens biogenesis and maintenance.Acts via its interaction with KIAA1543/Nezha, which anchorsmicrotubules at their minus-ends to zonula adherens, leading tothe recruitment of KIFC3 kinesin to the junctional site.{ECO:0000269|PubMed:19041755}. | May play an essential role in local proteolysis of theextracellular matrix and in leukocyte migration. Could play a rolein bone osteoclastic resorption. Cleaves KiSS1 at a Gly-|-Leubond. Cleaves type IV and type V collagen into large C-terminalthree quarter fragments and shorter N-terminal one quarterfragments. Degrades fibronectin but not laminin or Pz-peptide.{ECO:0000269|PubMed:1480034}. |
| Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at . * Minus value of BPloci means that the break pointn is located before the CDS. |
| - In-frame and retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
| Hgene | PLEKHA7 | chr11:16872738 | chr20:44638505 | ENST00000355661 | - | 8 | 23 | 54_87 | 232 | 1122 | Domain | WW 2 |
| Hgene | PLEKHA7 | chr11:16872738 | chr20:44638505 | ENST00000355661 | - | 8 | 23 | 9_42 | 232 | 1122 | Domain | WW 1 |
| Hgene | PLEKHA7 | chr11:16872738 | chr20:44638505 | ENST00000448080 | - | 8 | 23 | 54_87 | 232 | 1123 | Domain | WW 2 |
| Hgene | PLEKHA7 | chr11:16872738 | chr20:44638505 | ENST00000448080 | - | 8 | 23 | 9_42 | 232 | 1123 | Domain | WW 1 |
| Tgene | >MMP9 | chr11:16872738 | chr20:44638505 | ENST00000372330 | + | 0 | 13 | 225_273 | 46 | 708 | Domain | Fibronectin type-II 1 |
| Tgene | >MMP9 | chr11:16872738 | chr20:44638505 | ENST00000372330 | + | 0 | 13 | 283_331 | 46 | 708 | Domain | Fibronectin type-II 2 |
| Tgene | >MMP9 | chr11:16872738 | chr20:44638505 | ENST00000372330 | + | 0 | 13 | 342_390 | 46 | 708 | Domain | Fibronectin type-II 3 |
| Tgene | >MMP9 | chr11:16872738 | chr20:44638505 | ENST00000372330 | + | 0 | 13 | 97_104 | 46 | 708 | Motif | Cysteine switch |
| Tgene | >MMP9 | chr11:16872738 | chr20:44638505 | ENST00000372330 | + | 0 | 13 | 518_563 | 46 | 708 | Repeat | Note=Hemopexin 1 |
| Tgene | >MMP9 | chr11:16872738 | chr20:44638505 | ENST00000372330 | + | 0 | 13 | 564_608 | 46 | 708 | Repeat | Note=Hemopexin 2 |
| Tgene | >MMP9 | chr11:16872738 | chr20:44638505 | ENST00000372330 | + | 0 | 13 | 610_657 | 46 | 708 | Repeat | Note=Hemopexin 3 |
| Tgene | >MMP9 | chr11:16872738 | chr20:44638505 | ENST00000372330 | + | 0 | 13 | 658_704 | 46 | 708 | Repeat | Note=Hemopexin 4 |
| - In-frame and not-retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
| Hgene | >PLEKHA7 | chr11:16872738 | chr20:44638505 | ENST00000355661 | - | 8 | 23 | 1067_1094 | 232 | 1122 | Coiled coil | Ontology_term=ECO:0000255 |
| Hgene | >PLEKHA7 | chr11:16872738 | chr20:44638505 | ENST00000355661 | - | 8 | 23 | 700_801 | 232 | 1122 | Coiled coil | Ontology_term=ECO:0000255 |
| Hgene | >PLEKHA7 | chr11:16872738 | chr20:44638505 | ENST00000448080 | - | 8 | 23 | 1067_1094 | 232 | 1123 | Coiled coil | Ontology_term=ECO:0000255 |
| Hgene | >PLEKHA7 | chr11:16872738 | chr20:44638505 | ENST00000448080 | - | 8 | 23 | 700_801 | 232 | 1123 | Coiled coil | Ontology_term=ECO:0000255 |
| Hgene | >PLEKHA7 | chr11:16872738 | chr20:44638505 | ENST00000355661 | - | 8 | 23 | 567_599 | 232 | 1122 | Compositional bias | Note=Pro-rich |
| Hgene | >PLEKHA7 | chr11:16872738 | chr20:44638505 | ENST00000355661 | - | 8 | 23 | 845_942 | 232 | 1122 | Compositional bias | Note=Pro-rich |
| Hgene | >PLEKHA7 | chr11:16872738 | chr20:44638505 | ENST00000448080 | - | 8 | 23 | 567_599 | 232 | 1123 | Compositional bias | Note=Pro-rich |
| Hgene | >PLEKHA7 | chr11:16872738 | chr20:44638505 | ENST00000448080 | - | 8 | 23 | 845_942 | 232 | 1123 | Compositional bias | Note=Pro-rich |
| Hgene | >PLEKHA7 | chr11:16872738 | chr20:44638505 | ENST00000355661 | - | 8 | 23 | 164_282 | 232 | 1122 | Domain | PH |
| Hgene | >PLEKHA7 | chr11:16872738 | chr20:44638505 | ENST00000448080 | - | 8 | 23 | 164_282 | 232 | 1123 | Domain | PH |
Top |
FusionGeneSequence for PLEKHA7_MMP9 |
| For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. (nt: nucleotides, aa: amino acids) |
| * Fusion amino acid sequences. |
| >In-frame_PLEKHA7_ENST00000531066_chr11_16872738_-_MMP9_ENST00000372330_chr20_44638505_+_894aa MAAATVGRDTLPEHWSYGVCRDGRVFFINDQLRCTTWLHPRTGEPVNSGHMIRSDLPRGWEEGFTEEGASYFIDHNQQTTAFRHPVTGQF SPENSEFILQEEPNPHMSKQDRNQRPSSMVSETSTAGTASTLEAKPGPKIIKSSSKVHSFGKRDQAIRRNPNVPVVVRGWLHKQDSSGMR LWKRRWFVLADYCLFYYKDSREEAVLGSIPLPSYVISPVAPEDRISRKYSFKEYLYRYGYTRVAEMRGESKSLGPALLLLQKQLSLPETG ELDSATLKAMRTPRCGVPDLGRFQTFEGDLKWHHHNITYWIQNYSEDLPRAVIDDAFARAFALWSAVTPLTFTRVYSRDADIVIQFGVAE HGDGYPFDGKDGLLAHAFPPGPGIQGDAHFDDDELWSLGKGVVVPTRFGNADGAACHFPFIFEGRSYSACTTDGRSDGLPWCSTTANYDT DDRFGFCPSERLYTQDGNADGKPCQFPFIFQGQSYSACTTDGRSDGYRWCATTANYDRDKLFGFCPTRADSTVMGGNSAGELCVFPFTFL GKEYSTCTSEGRGDGRLWCATTSNFDSDKKWGFCPDQGYSLFLVAAHEFGHALGLDHSSVPEALMYPMYRFTEGPPLHKDDVNGIRHLYG PRPEPEPRPPTTTTPQPTAPPTVCPTGPPTVHPSERPTAGPTGPPSAGPTGPPTAGPSTATTVPLSPVDDACNVNIFDAIAEIGNQLYLF KDGKYWRFSEGRGSRPQGPFLIADKWPALPRKLDSVFEERLSKKLFFFSGRQVWVYTGASVLGPRRLDKLGLGADVAQVTGALRSGRGKM >In-frame_PLEKHA7_ENST00000355661_chr11_16872738_-_MMP9_ENST00000372330_chr20_44638505_+_894aa MAAATVGRDTLPEHWSYGVCRDGRVFFINDQLRCTTWLHPRTGEPVNSGHMIRSDLPRGWEEGFTEEGASYFIDHNQQTTAFRHPVTGQF SPENSEFILQEEPNPHMSKQDRNQRPSSMVSETSTAGTASTLEAKPGPKIIKSSSKVHSFGKRDQAIRRNPNVPVVVRGWLHKQDSSGMR LWKRRWFVLADYCLFYYKDSREEAVLGSIPLPSYVISPVAPEDRISRKYSFKEYLYRYGYTRVAEMRGESKSLGPALLLLQKQLSLPETG ELDSATLKAMRTPRCGVPDLGRFQTFEGDLKWHHHNITYWIQNYSEDLPRAVIDDAFARAFALWSAVTPLTFTRVYSRDADIVIQFGVAE HGDGYPFDGKDGLLAHAFPPGPGIQGDAHFDDDELWSLGKGVVVPTRFGNADGAACHFPFIFEGRSYSACTTDGRSDGLPWCSTTANYDT DDRFGFCPSERLYTQDGNADGKPCQFPFIFQGQSYSACTTDGRSDGYRWCATTANYDRDKLFGFCPTRADSTVMGGNSAGELCVFPFTFL GKEYSTCTSEGRGDGRLWCATTSNFDSDKKWGFCPDQGYSLFLVAAHEFGHALGLDHSSVPEALMYPMYRFTEGPPLHKDDVNGIRHLYG PRPEPEPRPPTTTTPQPTAPPTVCPTGPPTVHPSERPTAGPTGPPSAGPTGPPTAGPSTATTVPLSPVDDACNVNIFDAIAEIGNQLYLF KDGKYWRFSEGRGSRPQGPFLIADKWPALPRKLDSVFEERLSKKLFFFSGRQVWVYTGASVLGPRRLDKLGLGADVAQVTGALRSGRGKM >In-frame_PLEKHA7_ENST00000448080_chr11_16872738_-_MMP9_ENST00000372330_chr20_44638505_+_894aa MAAATVGRDTLPEHWSYGVCRDGRVFFINDQLRCTTWLHPRTGEPVNSGHMIRSDLPRGWEEGFTEEGASYFIDHNQQTTAFRHPVTGQF SPENSEFILQEEPNPHMSKQDRNQRPSSMVSETSTAGTASTLEAKPGPKIIKSSSKVHSFGKRDQAIRRNPNVPVVVRGWLHKQDSSGMR LWKRRWFVLADYCLFYYKDSREEAVLGSIPLPSYVISPVAPEDRISRKYSFKEYLYRYGYTRVAEMRGESKSLGPALLLLQKQLSLPETG ELDSATLKAMRTPRCGVPDLGRFQTFEGDLKWHHHNITYWIQNYSEDLPRAVIDDAFARAFALWSAVTPLTFTRVYSRDADIVIQFGVAE HGDGYPFDGKDGLLAHAFPPGPGIQGDAHFDDDELWSLGKGVVVPTRFGNADGAACHFPFIFEGRSYSACTTDGRSDGLPWCSTTANYDT DDRFGFCPSERLYTQDGNADGKPCQFPFIFQGQSYSACTTDGRSDGYRWCATTANYDRDKLFGFCPTRADSTVMGGNSAGELCVFPFTFL GKEYSTCTSEGRGDGRLWCATTSNFDSDKKWGFCPDQGYSLFLVAAHEFGHALGLDHSSVPEALMYPMYRFTEGPPLHKDDVNGIRHLYG PRPEPEPRPPTTTTPQPTAPPTVCPTGPPTVHPSERPTAGPTGPPSAGPTGPPTAGPSTATTVPLSPVDDACNVNIFDAIAEIGNQLYLF KDGKYWRFSEGRGSRPQGPFLIADKWPALPRKLDSVFEERLSKKLFFFSGRQVWVYTGASVLGPRRLDKLGLGADVAQVTGALRSGRGKM |
| * Fusion transcript sequences (only coding sequence (CDS) region). |
| >In-frame_PLEKHA7_ENST00000531066_chr11_16872738_-_MMP9_ENST00000372330_chr20_44638505_+_2682nt ATGGCGGCGGCGACGGTCGGGCGGGACACTTTACCTGAGCATTGGTCCTACGGGGTGTGCCGGGATGGCCGCGTCTTCTTCATCAATGAC CAGCTCCGCTGCACGACCTGGCTGCATCCGCGCACCGGGGAGCCCGTCAACTCGGGCCACATGATCCGCTCAGACCTGCCCCGCGGCTGG GAGGAGGGCTTCACGGAGGAGGGCGCCAGCTACTTCATCGACCATAACCAGCAGACCACAGCATTCAGGCATCCTGTGACGGGACAGTTT TCTCCAGAAAATAGTGAATTCATTCTTCAAGAAGAGCCGAATCCACATATGTCGAAGCAAGACAGAAACCAAAGACCGTCCAGCATGGTC AGTGAAACATCCACGGCTGGGACCGCCTCCACCCTGGAGGCCAAGCCTGGACCCAAGATCATAAAGTCCAGCAGTAAAGTCCACAGCTTT GGGAAGAGAGACCAGGCCATTCGGAGGAACCCCAATGTTCCCGTGGTGGTGAGGGGCTGGCTGCACAAGCAGGACAGTTCTGGGATGAGG CTGTGGAAAAGGAGGTGGTTTGTGCTTGCTGATTACTGCTTATTTTACTATAAAGACAGCCGAGAAGAAGCGGTCCTCGGGAGCATCCCC TTGCCCAGCTACGTGATCTCTCCTGTGGCCCCTGAGGATCGCATAAGCCGCAAATATTCCTTTAAGGAATACCTGTACCGCTATGGTTAC ACTCGGGTGGCAGAGATGCGTGGAGAGTCGAAATCTCTGGGGCCTGCGCTGCTGCTTCTCCAGAAGCAACTGTCCCTGCCCGAGACCGGT GAGCTGGATAGCGCCACGCTGAAGGCCATGCGAACCCCACGGTGCGGGGTCCCAGACCTGGGCAGATTCCAAACCTTTGAGGGCGACCTC AAGTGGCACCACCACAACATCACCTATTGGATCCAAAACTACTCGGAAGACTTGCCGCGGGCGGTGATTGACGACGCCTTTGCCCGCGCC TTCGCACTGTGGAGCGCGGTGACGCCGCTCACCTTCACTCGCGTGTACAGCCGGGACGCAGACATCGTCATCCAGTTTGGTGTCGCGGAG CACGGAGACGGGTATCCCTTCGACGGGAAGGACGGGCTCCTGGCACACGCCTTTCCTCCTGGCCCCGGCATTCAGGGAGACGCCCATTTC GACGATGACGAGTTGTGGTCCCTGGGCAAGGGCGTCGTGGTTCCAACTCGGTTTGGAAACGCAGATGGCGCGGCCTGCCACTTCCCCTTC ATCTTCGAGGGCCGCTCCTACTCTGCCTGCACCACCGACGGTCGCTCCGACGGCTTGCCCTGGTGCAGTACCACGGCCAACTACGACACC GACGACCGGTTTGGCTTCTGCCCCAGCGAGAGACTCTACACCCAGGACGGCAATGCTGATGGGAAACCCTGCCAGTTTCCATTCATCTTC CAAGGCCAATCCTACTCCGCCTGCACCACGGACGGTCGCTCCGACGGCTACCGCTGGTGCGCCACCACCGCCAACTACGACCGGGACAAG CTCTTCGGCTTCTGCCCGACCCGAGCTGACTCGACGGTGATGGGGGGCAACTCGGCGGGGGAGCTGTGCGTCTTCCCCTTCACTTTCCTG GGTAAGGAGTACTCGACCTGTACCAGCGAGGGCCGCGGAGATGGGCGCCTCTGGTGCGCTACCACCTCGAACTTTGACAGCGACAAGAAG TGGGGCTTCTGCCCGGACCAAGGATACAGTTTGTTCCTCGTGGCGGCGCATGAGTTCGGCCACGCGCTGGGCTTAGATCATTCCTCAGTG CCGGAGGCGCTCATGTACCCTATGTACCGCTTCACTGAGGGGCCCCCCTTGCATAAGGACGACGTGAATGGCATCCGGCACCTCTATGGT CCTCGCCCTGAACCTGAGCCACGGCCTCCAACCACCACCACACCGCAGCCCACGGCTCCCCCGACGGTCTGCCCCACCGGACCCCCCACT GTCCACCCCTCAGAGCGCCCCACAGCTGGCCCCACAGGTCCCCCCTCAGCTGGCCCCACAGGTCCCCCCACTGCTGGCCCTTCTACGGCC ACTACTGTGCCTTTGAGTCCGGTGGACGATGCCTGCAACGTGAACATCTTCGACGCCATCGCGGAGATTGGGAACCAGCTGTATTTGTTC AAGGATGGGAAGTACTGGCGATTCTCTGAGGGCAGGGGGAGCCGGCCGCAGGGCCCCTTCCTTATCGCCGACAAGTGGCCCGCGCTGCCC CGCAAGCTGGACTCGGTCTTTGAGGAGCGGCTCTCCAAGAAGCTTTTCTTCTTCTCTGGGCGCCAGGTGTGGGTGTACACAGGCGCGTCG GTGCTGGGCCCGAGGCGTCTGGACAAGCTGGGCCTGGGAGCCGACGTGGCCCAGGTGACCGGGGCCCTCCGGAGTGGCAGGGGGAAGATG CTGCTGTTCAGCGGGCGGCGCCTCTGGAGGTTCGACGTGAAGGCGCAGATGGTGGATCCCCGGAGCGCCAGCGAGGTGGACCGGATGTTC CCCGGGGTGCCTTTGGACACGCACGACGTCTTCCAGTACCGAGAGAAAGCCTATTTCTGCCAGGACCGCTTCTACTGGCGCGTGAGTTCC >In-frame_PLEKHA7_ENST00000355661_chr11_16872738_-_MMP9_ENST00000372330_chr20_44638505_+_2682nt ATGGCGGCGGCGACGGTCGGGCGGGACACTTTACCTGAGCATTGGTCCTACGGGGTGTGCCGGGATGGCCGCGTCTTCTTCATCAATGAC CAGCTCCGCTGCACGACCTGGCTGCATCCGCGCACCGGGGAGCCCGTCAACTCGGGCCACATGATCCGCTCAGACCTGCCCCGCGGCTGG GAGGAGGGCTTCACGGAGGAGGGCGCCAGCTACTTCATCGACCATAACCAGCAGACCACAGCATTCAGGCATCCTGTGACGGGACAGTTT TCTCCAGAAAATAGTGAATTCATTCTTCAAGAAGAGCCGAATCCACATATGTCGAAGCAAGACAGAAACCAAAGACCGTCCAGCATGGTC AGTGAAACATCCACGGCTGGGACCGCCTCCACCCTGGAGGCCAAGCCTGGACCCAAGATCATAAAGTCCAGCAGTAAAGTCCACAGCTTT GGGAAGAGAGACCAGGCCATTCGGAGGAACCCCAATGTTCCCGTGGTGGTGAGGGGCTGGCTGCACAAGCAGGACAGTTCTGGGATGAGG CTGTGGAAAAGGAGGTGGTTTGTGCTTGCTGATTACTGCTTATTTTACTATAAAGACAGCCGAGAAGAAGCGGTCCTCGGGAGCATCCCC TTGCCCAGCTACGTGATCTCTCCTGTGGCCCCTGAGGATCGCATAAGCCGCAAATATTCCTTTAAGGAATACCTGTACCGCTATGGTTAC ACTCGGGTGGCAGAGATGCGTGGAGAGTCGAAATCTCTGGGGCCTGCGCTGCTGCTTCTCCAGAAGCAACTGTCCCTGCCCGAGACCGGT GAGCTGGATAGCGCCACGCTGAAGGCCATGCGAACCCCACGGTGCGGGGTCCCAGACCTGGGCAGATTCCAAACCTTTGAGGGCGACCTC AAGTGGCACCACCACAACATCACCTATTGGATCCAAAACTACTCGGAAGACTTGCCGCGGGCGGTGATTGACGACGCCTTTGCCCGCGCC TTCGCACTGTGGAGCGCGGTGACGCCGCTCACCTTCACTCGCGTGTACAGCCGGGACGCAGACATCGTCATCCAGTTTGGTGTCGCGGAG CACGGAGACGGGTATCCCTTCGACGGGAAGGACGGGCTCCTGGCACACGCCTTTCCTCCTGGCCCCGGCATTCAGGGAGACGCCCATTTC GACGATGACGAGTTGTGGTCCCTGGGCAAGGGCGTCGTGGTTCCAACTCGGTTTGGAAACGCAGATGGCGCGGCCTGCCACTTCCCCTTC ATCTTCGAGGGCCGCTCCTACTCTGCCTGCACCACCGACGGTCGCTCCGACGGCTTGCCCTGGTGCAGTACCACGGCCAACTACGACACC GACGACCGGTTTGGCTTCTGCCCCAGCGAGAGACTCTACACCCAGGACGGCAATGCTGATGGGAAACCCTGCCAGTTTCCATTCATCTTC CAAGGCCAATCCTACTCCGCCTGCACCACGGACGGTCGCTCCGACGGCTACCGCTGGTGCGCCACCACCGCCAACTACGACCGGGACAAG CTCTTCGGCTTCTGCCCGACCCGAGCTGACTCGACGGTGATGGGGGGCAACTCGGCGGGGGAGCTGTGCGTCTTCCCCTTCACTTTCCTG GGTAAGGAGTACTCGACCTGTACCAGCGAGGGCCGCGGAGATGGGCGCCTCTGGTGCGCTACCACCTCGAACTTTGACAGCGACAAGAAG TGGGGCTTCTGCCCGGACCAAGGATACAGTTTGTTCCTCGTGGCGGCGCATGAGTTCGGCCACGCGCTGGGCTTAGATCATTCCTCAGTG CCGGAGGCGCTCATGTACCCTATGTACCGCTTCACTGAGGGGCCCCCCTTGCATAAGGACGACGTGAATGGCATCCGGCACCTCTATGGT CCTCGCCCTGAACCTGAGCCACGGCCTCCAACCACCACCACACCGCAGCCCACGGCTCCCCCGACGGTCTGCCCCACCGGACCCCCCACT GTCCACCCCTCAGAGCGCCCCACAGCTGGCCCCACAGGTCCCCCCTCAGCTGGCCCCACAGGTCCCCCCACTGCTGGCCCTTCTACGGCC ACTACTGTGCCTTTGAGTCCGGTGGACGATGCCTGCAACGTGAACATCTTCGACGCCATCGCGGAGATTGGGAACCAGCTGTATTTGTTC AAGGATGGGAAGTACTGGCGATTCTCTGAGGGCAGGGGGAGCCGGCCGCAGGGCCCCTTCCTTATCGCCGACAAGTGGCCCGCGCTGCCC CGCAAGCTGGACTCGGTCTTTGAGGAGCGGCTCTCCAAGAAGCTTTTCTTCTTCTCTGGGCGCCAGGTGTGGGTGTACACAGGCGCGTCG GTGCTGGGCCCGAGGCGTCTGGACAAGCTGGGCCTGGGAGCCGACGTGGCCCAGGTGACCGGGGCCCTCCGGAGTGGCAGGGGGAAGATG CTGCTGTTCAGCGGGCGGCGCCTCTGGAGGTTCGACGTGAAGGCGCAGATGGTGGATCCCCGGAGCGCCAGCGAGGTGGACCGGATGTTC CCCGGGGTGCCTTTGGACACGCACGACGTCTTCCAGTACCGAGAGAAAGCCTATTTCTGCCAGGACCGCTTCTACTGGCGCGTGAGTTCC >In-frame_PLEKHA7_ENST00000448080_chr11_16872738_-_MMP9_ENST00000372330_chr20_44638505_+_2682nt ATGGCGGCGGCGACGGTCGGGCGGGACACTTTACCTGAGCATTGGTCCTACGGGGTGTGCCGGGATGGCCGCGTCTTCTTCATCAATGAC CAGCTCCGCTGCACGACCTGGCTGCATCCGCGCACCGGGGAGCCCGTCAACTCGGGCCACATGATCCGCTCAGACCTGCCCCGCGGCTGG GAGGAGGGCTTCACGGAGGAGGGCGCCAGCTACTTCATCGACCATAACCAGCAGACCACAGCATTCAGGCATCCTGTGACGGGACAGTTT TCTCCAGAAAATAGTGAATTCATTCTTCAAGAAGAGCCGAATCCACATATGTCGAAGCAAGACAGAAACCAAAGACCGTCCAGCATGGTC AGTGAAACATCCACGGCTGGGACCGCCTCCACCCTGGAGGCCAAGCCTGGACCCAAGATCATAAAGTCCAGCAGTAAAGTCCACAGCTTT GGGAAGAGAGACCAGGCCATTCGGAGGAACCCCAATGTTCCCGTGGTGGTGAGGGGCTGGCTGCACAAGCAGGACAGTTCTGGGATGAGG CTGTGGAAAAGGAGGTGGTTTGTGCTTGCTGATTACTGCTTATTTTACTATAAAGACAGCCGAGAAGAAGCGGTCCTCGGGAGCATCCCC TTGCCCAGCTACGTGATCTCTCCTGTGGCCCCTGAGGATCGCATAAGCCGCAAATATTCCTTTAAGGAATACCTGTACCGCTATGGTTAC ACTCGGGTGGCAGAGATGCGTGGAGAGTCGAAATCTCTGGGGCCTGCGCTGCTGCTTCTCCAGAAGCAACTGTCCCTGCCCGAGACCGGT GAGCTGGATAGCGCCACGCTGAAGGCCATGCGAACCCCACGGTGCGGGGTCCCAGACCTGGGCAGATTCCAAACCTTTGAGGGCGACCTC AAGTGGCACCACCACAACATCACCTATTGGATCCAAAACTACTCGGAAGACTTGCCGCGGGCGGTGATTGACGACGCCTTTGCCCGCGCC TTCGCACTGTGGAGCGCGGTGACGCCGCTCACCTTCACTCGCGTGTACAGCCGGGACGCAGACATCGTCATCCAGTTTGGTGTCGCGGAG CACGGAGACGGGTATCCCTTCGACGGGAAGGACGGGCTCCTGGCACACGCCTTTCCTCCTGGCCCCGGCATTCAGGGAGACGCCCATTTC GACGATGACGAGTTGTGGTCCCTGGGCAAGGGCGTCGTGGTTCCAACTCGGTTTGGAAACGCAGATGGCGCGGCCTGCCACTTCCCCTTC ATCTTCGAGGGCCGCTCCTACTCTGCCTGCACCACCGACGGTCGCTCCGACGGCTTGCCCTGGTGCAGTACCACGGCCAACTACGACACC GACGACCGGTTTGGCTTCTGCCCCAGCGAGAGACTCTACACCCAGGACGGCAATGCTGATGGGAAACCCTGCCAGTTTCCATTCATCTTC CAAGGCCAATCCTACTCCGCCTGCACCACGGACGGTCGCTCCGACGGCTACCGCTGGTGCGCCACCACCGCCAACTACGACCGGGACAAG CTCTTCGGCTTCTGCCCGACCCGAGCTGACTCGACGGTGATGGGGGGCAACTCGGCGGGGGAGCTGTGCGTCTTCCCCTTCACTTTCCTG GGTAAGGAGTACTCGACCTGTACCAGCGAGGGCCGCGGAGATGGGCGCCTCTGGTGCGCTACCACCTCGAACTTTGACAGCGACAAGAAG TGGGGCTTCTGCCCGGACCAAGGATACAGTTTGTTCCTCGTGGCGGCGCATGAGTTCGGCCACGCGCTGGGCTTAGATCATTCCTCAGTG CCGGAGGCGCTCATGTACCCTATGTACCGCTTCACTGAGGGGCCCCCCTTGCATAAGGACGACGTGAATGGCATCCGGCACCTCTATGGT CCTCGCCCTGAACCTGAGCCACGGCCTCCAACCACCACCACACCGCAGCCCACGGCTCCCCCGACGGTCTGCCCCACCGGACCCCCCACT GTCCACCCCTCAGAGCGCCCCACAGCTGGCCCCACAGGTCCCCCCTCAGCTGGCCCCACAGGTCCCCCCACTGCTGGCCCTTCTACGGCC ACTACTGTGCCTTTGAGTCCGGTGGACGATGCCTGCAACGTGAACATCTTCGACGCCATCGCGGAGATTGGGAACCAGCTGTATTTGTTC AAGGATGGGAAGTACTGGCGATTCTCTGAGGGCAGGGGGAGCCGGCCGCAGGGCCCCTTCCTTATCGCCGACAAGTGGCCCGCGCTGCCC CGCAAGCTGGACTCGGTCTTTGAGGAGCGGCTCTCCAAGAAGCTTTTCTTCTTCTCTGGGCGCCAGGTGTGGGTGTACACAGGCGCGTCG GTGCTGGGCCCGAGGCGTCTGGACAAGCTGGGCCTGGGAGCCGACGTGGCCCAGGTGACCGGGGCCCTCCGGAGTGGCAGGGGGAAGATG CTGCTGTTCAGCGGGCGGCGCCTCTGGAGGTTCGACGTGAAGGCGCAGATGGTGGATCCCCGGAGCGCCAGCGAGGTGGACCGGATGTTC CCCGGGGTGCCTTTGGACACGCACGACGTCTTCCAGTACCGAGAGAAAGCCTATTTCTGCCAGGACCGCTTCTACTGGCGCGTGAGTTCC |
| * Fusion transcript sequences (Full-length transcript). |
| >In-frame_PLEKHA7_ENST00000531066_chr11_16872738_-_MMP9_ENST00000372330_chr20_44638505_+_2917nt CCCCCTCCCCCCCACCCCGCGGCGGCTCCGCGCTCGGCGAACATGGCGGCGGCGACGGTCGGGCGGGACACTTTACCTGAGCATTGGTCC TACGGGGTGTGCCGGGATGGCCGCGTCTTCTTCATCAATGACCAGCTCCGCTGCACGACCTGGCTGCATCCGCGCACCGGGGAGCCCGTC AACTCGGGCCACATGATCCGCTCAGACCTGCCCCGCGGCTGGGAGGAGGGCTTCACGGAGGAGGGCGCCAGCTACTTCATCGACCATAAC CAGCAGACCACAGCATTCAGGCATCCTGTGACGGGACAGTTTTCTCCAGAAAATAGTGAATTCATTCTTCAAGAAGAGCCGAATCCACAT ATGTCGAAGCAAGACAGAAACCAAAGACCGTCCAGCATGGTCAGTGAAACATCCACGGCTGGGACCGCCTCCACCCTGGAGGCCAAGCCT GGACCCAAGATCATAAAGTCCAGCAGTAAAGTCCACAGCTTTGGGAAGAGAGACCAGGCCATTCGGAGGAACCCCAATGTTCCCGTGGTG GTGAGGGGCTGGCTGCACAAGCAGGACAGTTCTGGGATGAGGCTGTGGAAAAGGAGGTGGTTTGTGCTTGCTGATTACTGCTTATTTTAC TATAAAGACAGCCGAGAAGAAGCGGTCCTCGGGAGCATCCCCTTGCCCAGCTACGTGATCTCTCCTGTGGCCCCTGAGGATCGCATAAGC CGCAAATATTCCTTTAAGGAATACCTGTACCGCTATGGTTACACTCGGGTGGCAGAGATGCGTGGAGAGTCGAAATCTCTGGGGCCTGCG CTGCTGCTTCTCCAGAAGCAACTGTCCCTGCCCGAGACCGGTGAGCTGGATAGCGCCACGCTGAAGGCCATGCGAACCCCACGGTGCGGG GTCCCAGACCTGGGCAGATTCCAAACCTTTGAGGGCGACCTCAAGTGGCACCACCACAACATCACCTATTGGATCCAAAACTACTCGGAA GACTTGCCGCGGGCGGTGATTGACGACGCCTTTGCCCGCGCCTTCGCACTGTGGAGCGCGGTGACGCCGCTCACCTTCACTCGCGTGTAC AGCCGGGACGCAGACATCGTCATCCAGTTTGGTGTCGCGGAGCACGGAGACGGGTATCCCTTCGACGGGAAGGACGGGCTCCTGGCACAC GCCTTTCCTCCTGGCCCCGGCATTCAGGGAGACGCCCATTTCGACGATGACGAGTTGTGGTCCCTGGGCAAGGGCGTCGTGGTTCCAACT CGGTTTGGAAACGCAGATGGCGCGGCCTGCCACTTCCCCTTCATCTTCGAGGGCCGCTCCTACTCTGCCTGCACCACCGACGGTCGCTCC GACGGCTTGCCCTGGTGCAGTACCACGGCCAACTACGACACCGACGACCGGTTTGGCTTCTGCCCCAGCGAGAGACTCTACACCCAGGAC GGCAATGCTGATGGGAAACCCTGCCAGTTTCCATTCATCTTCCAAGGCCAATCCTACTCCGCCTGCACCACGGACGGTCGCTCCGACGGC TACCGCTGGTGCGCCACCACCGCCAACTACGACCGGGACAAGCTCTTCGGCTTCTGCCCGACCCGAGCTGACTCGACGGTGATGGGGGGC AACTCGGCGGGGGAGCTGTGCGTCTTCCCCTTCACTTTCCTGGGTAAGGAGTACTCGACCTGTACCAGCGAGGGCCGCGGAGATGGGCGC CTCTGGTGCGCTACCACCTCGAACTTTGACAGCGACAAGAAGTGGGGCTTCTGCCCGGACCAAGGATACAGTTTGTTCCTCGTGGCGGCG CATGAGTTCGGCCACGCGCTGGGCTTAGATCATTCCTCAGTGCCGGAGGCGCTCATGTACCCTATGTACCGCTTCACTGAGGGGCCCCCC TTGCATAAGGACGACGTGAATGGCATCCGGCACCTCTATGGTCCTCGCCCTGAACCTGAGCCACGGCCTCCAACCACCACCACACCGCAG CCCACGGCTCCCCCGACGGTCTGCCCCACCGGACCCCCCACTGTCCACCCCTCAGAGCGCCCCACAGCTGGCCCCACAGGTCCCCCCTCA GCTGGCCCCACAGGTCCCCCCACTGCTGGCCCTTCTACGGCCACTACTGTGCCTTTGAGTCCGGTGGACGATGCCTGCAACGTGAACATC TTCGACGCCATCGCGGAGATTGGGAACCAGCTGTATTTGTTCAAGGATGGGAAGTACTGGCGATTCTCTGAGGGCAGGGGGAGCCGGCCG CAGGGCCCCTTCCTTATCGCCGACAAGTGGCCCGCGCTGCCCCGCAAGCTGGACTCGGTCTTTGAGGAGCGGCTCTCCAAGAAGCTTTTC TTCTTCTCTGGGCGCCAGGTGTGGGTGTACACAGGCGCGTCGGTGCTGGGCCCGAGGCGTCTGGACAAGCTGGGCCTGGGAGCCGACGTG GCCCAGGTGACCGGGGCCCTCCGGAGTGGCAGGGGGAAGATGCTGCTGTTCAGCGGGCGGCGCCTCTGGAGGTTCGACGTGAAGGCGCAG ATGGTGGATCCCCGGAGCGCCAGCGAGGTGGACCGGATGTTCCCCGGGGTGCCTTTGGACACGCACGACGTCTTCCAGTACCGAGAGAAA GCCTATTTCTGCCAGGACCGCTTCTACTGGCGCGTGAGTTCCCGGAGTGAGTTGAACCAGGTGGACCAAGTGGGCTACGTGACCTATGAC ATCCTGCAGTGCCCTGAGGACTAGGGCTCCCGTCCTGCTTTGGCAGTGCCATGTAAATCCCCACTGGGACCAACCCTGGGGAAGGAGCCA GTTTGCCGGATACAAACTGGTATTCTGTTCTGGAGGAAAGGGAGGAGTGGAGGTGGGCTGGGCCCTCTCTTCTCACCTTTGTTTTTTGTT >In-frame_PLEKHA7_ENST00000355661_chr11_16872738_-_MMP9_ENST00000372330_chr20_44638505_+_2886nt GCTCGGCGAACATGGCGGCGGCGACGGTCGGGCGGGACACTTTACCTGAGCATTGGTCCTACGGGGTGTGCCGGGATGGCCGCGTCTTCT TCATCAATGACCAGCTCCGCTGCACGACCTGGCTGCATCCGCGCACCGGGGAGCCCGTCAACTCGGGCCACATGATCCGCTCAGACCTGC CCCGCGGCTGGGAGGAGGGCTTCACGGAGGAGGGCGCCAGCTACTTCATCGACCATAACCAGCAGACCACAGCATTCAGGCATCCTGTGA CGGGACAGTTTTCTCCAGAAAATAGTGAATTCATTCTTCAAGAAGAGCCGAATCCACATATGTCGAAGCAAGACAGAAACCAAAGACCGT CCAGCATGGTCAGTGAAACATCCACGGCTGGGACCGCCTCCACCCTGGAGGCCAAGCCTGGACCCAAGATCATAAAGTCCAGCAGTAAAG TCCACAGCTTTGGGAAGAGAGACCAGGCCATTCGGAGGAACCCCAATGTTCCCGTGGTGGTGAGGGGCTGGCTGCACAAGCAGGACAGTT CTGGGATGAGGCTGTGGAAAAGGAGGTGGTTTGTGCTTGCTGATTACTGCTTATTTTACTATAAAGACAGCCGAGAAGAAGCGGTCCTCG GGAGCATCCCCTTGCCCAGCTACGTGATCTCTCCTGTGGCCCCTGAGGATCGCATAAGCCGCAAATATTCCTTTAAGGAATACCTGTACC GCTATGGTTACACTCGGGTGGCAGAGATGCGTGGAGAGTCGAAATCTCTGGGGCCTGCGCTGCTGCTTCTCCAGAAGCAACTGTCCCTGC CCGAGACCGGTGAGCTGGATAGCGCCACGCTGAAGGCCATGCGAACCCCACGGTGCGGGGTCCCAGACCTGGGCAGATTCCAAACCTTTG AGGGCGACCTCAAGTGGCACCACCACAACATCACCTATTGGATCCAAAACTACTCGGAAGACTTGCCGCGGGCGGTGATTGACGACGCCT TTGCCCGCGCCTTCGCACTGTGGAGCGCGGTGACGCCGCTCACCTTCACTCGCGTGTACAGCCGGGACGCAGACATCGTCATCCAGTTTG GTGTCGCGGAGCACGGAGACGGGTATCCCTTCGACGGGAAGGACGGGCTCCTGGCACACGCCTTTCCTCCTGGCCCCGGCATTCAGGGAG ACGCCCATTTCGACGATGACGAGTTGTGGTCCCTGGGCAAGGGCGTCGTGGTTCCAACTCGGTTTGGAAACGCAGATGGCGCGGCCTGCC ACTTCCCCTTCATCTTCGAGGGCCGCTCCTACTCTGCCTGCACCACCGACGGTCGCTCCGACGGCTTGCCCTGGTGCAGTACCACGGCCA ACTACGACACCGACGACCGGTTTGGCTTCTGCCCCAGCGAGAGACTCTACACCCAGGACGGCAATGCTGATGGGAAACCCTGCCAGTTTC CATTCATCTTCCAAGGCCAATCCTACTCCGCCTGCACCACGGACGGTCGCTCCGACGGCTACCGCTGGTGCGCCACCACCGCCAACTACG ACCGGGACAAGCTCTTCGGCTTCTGCCCGACCCGAGCTGACTCGACGGTGATGGGGGGCAACTCGGCGGGGGAGCTGTGCGTCTTCCCCT TCACTTTCCTGGGTAAGGAGTACTCGACCTGTACCAGCGAGGGCCGCGGAGATGGGCGCCTCTGGTGCGCTACCACCTCGAACTTTGACA GCGACAAGAAGTGGGGCTTCTGCCCGGACCAAGGATACAGTTTGTTCCTCGTGGCGGCGCATGAGTTCGGCCACGCGCTGGGCTTAGATC ATTCCTCAGTGCCGGAGGCGCTCATGTACCCTATGTACCGCTTCACTGAGGGGCCCCCCTTGCATAAGGACGACGTGAATGGCATCCGGC ACCTCTATGGTCCTCGCCCTGAACCTGAGCCACGGCCTCCAACCACCACCACACCGCAGCCCACGGCTCCCCCGACGGTCTGCCCCACCG GACCCCCCACTGTCCACCCCTCAGAGCGCCCCACAGCTGGCCCCACAGGTCCCCCCTCAGCTGGCCCCACAGGTCCCCCCACTGCTGGCC CTTCTACGGCCACTACTGTGCCTTTGAGTCCGGTGGACGATGCCTGCAACGTGAACATCTTCGACGCCATCGCGGAGATTGGGAACCAGC TGTATTTGTTCAAGGATGGGAAGTACTGGCGATTCTCTGAGGGCAGGGGGAGCCGGCCGCAGGGCCCCTTCCTTATCGCCGACAAGTGGC CCGCGCTGCCCCGCAAGCTGGACTCGGTCTTTGAGGAGCGGCTCTCCAAGAAGCTTTTCTTCTTCTCTGGGCGCCAGGTGTGGGTGTACA CAGGCGCGTCGGTGCTGGGCCCGAGGCGTCTGGACAAGCTGGGCCTGGGAGCCGACGTGGCCCAGGTGACCGGGGCCCTCCGGAGTGGCA GGGGGAAGATGCTGCTGTTCAGCGGGCGGCGCCTCTGGAGGTTCGACGTGAAGGCGCAGATGGTGGATCCCCGGAGCGCCAGCGAGGTGG ACCGGATGTTCCCCGGGGTGCCTTTGGACACGCACGACGTCTTCCAGTACCGAGAGAAAGCCTATTTCTGCCAGGACCGCTTCTACTGGC GCGTGAGTTCCCGGAGTGAGTTGAACCAGGTGGACCAAGTGGGCTACGTGACCTATGACATCCTGCAGTGCCCTGAGGACTAGGGCTCCC GTCCTGCTTTGGCAGTGCCATGTAAATCCCCACTGGGACCAACCCTGGGGAAGGAGCCAGTTTGCCGGATACAAACTGGTATTCTGTTCT GGAGGAAAGGGAGGAGTGGAGGTGGGCTGGGCCCTCTCTTCTCACCTTTGTTTTTTGTTGGAGTGTTTCTAATAAACTTGGATTCTCTAA >In-frame_PLEKHA7_ENST00000448080_chr11_16872738_-_MMP9_ENST00000372330_chr20_44638505_+_2890nt CCGCGCTCGGCGAACATGGCGGCGGCGACGGTCGGGCGGGACACTTTACCTGAGCATTGGTCCTACGGGGTGTGCCGGGATGGCCGCGTC TTCTTCATCAATGACCAGCTCCGCTGCACGACCTGGCTGCATCCGCGCACCGGGGAGCCCGTCAACTCGGGCCACATGATCCGCTCAGAC CTGCCCCGCGGCTGGGAGGAGGGCTTCACGGAGGAGGGCGCCAGCTACTTCATCGACCATAACCAGCAGACCACAGCATTCAGGCATCCT GTGACGGGACAGTTTTCTCCAGAAAATAGTGAATTCATTCTTCAAGAAGAGCCGAATCCACATATGTCGAAGCAAGACAGAAACCAAAGA CCGTCCAGCATGGTCAGTGAAACATCCACGGCTGGGACCGCCTCCACCCTGGAGGCCAAGCCTGGACCCAAGATCATAAAGTCCAGCAGT AAAGTCCACAGCTTTGGGAAGAGAGACCAGGCCATTCGGAGGAACCCCAATGTTCCCGTGGTGGTGAGGGGCTGGCTGCACAAGCAGGAC AGTTCTGGGATGAGGCTGTGGAAAAGGAGGTGGTTTGTGCTTGCTGATTACTGCTTATTTTACTATAAAGACAGCCGAGAAGAAGCGGTC CTCGGGAGCATCCCCTTGCCCAGCTACGTGATCTCTCCTGTGGCCCCTGAGGATCGCATAAGCCGCAAATATTCCTTTAAGGAATACCTG TACCGCTATGGTTACACTCGGGTGGCAGAGATGCGTGGAGAGTCGAAATCTCTGGGGCCTGCGCTGCTGCTTCTCCAGAAGCAACTGTCC CTGCCCGAGACCGGTGAGCTGGATAGCGCCACGCTGAAGGCCATGCGAACCCCACGGTGCGGGGTCCCAGACCTGGGCAGATTCCAAACC TTTGAGGGCGACCTCAAGTGGCACCACCACAACATCACCTATTGGATCCAAAACTACTCGGAAGACTTGCCGCGGGCGGTGATTGACGAC GCCTTTGCCCGCGCCTTCGCACTGTGGAGCGCGGTGACGCCGCTCACCTTCACTCGCGTGTACAGCCGGGACGCAGACATCGTCATCCAG TTTGGTGTCGCGGAGCACGGAGACGGGTATCCCTTCGACGGGAAGGACGGGCTCCTGGCACACGCCTTTCCTCCTGGCCCCGGCATTCAG GGAGACGCCCATTTCGACGATGACGAGTTGTGGTCCCTGGGCAAGGGCGTCGTGGTTCCAACTCGGTTTGGAAACGCAGATGGCGCGGCC TGCCACTTCCCCTTCATCTTCGAGGGCCGCTCCTACTCTGCCTGCACCACCGACGGTCGCTCCGACGGCTTGCCCTGGTGCAGTACCACG GCCAACTACGACACCGACGACCGGTTTGGCTTCTGCCCCAGCGAGAGACTCTACACCCAGGACGGCAATGCTGATGGGAAACCCTGCCAG TTTCCATTCATCTTCCAAGGCCAATCCTACTCCGCCTGCACCACGGACGGTCGCTCCGACGGCTACCGCTGGTGCGCCACCACCGCCAAC TACGACCGGGACAAGCTCTTCGGCTTCTGCCCGACCCGAGCTGACTCGACGGTGATGGGGGGCAACTCGGCGGGGGAGCTGTGCGTCTTC CCCTTCACTTTCCTGGGTAAGGAGTACTCGACCTGTACCAGCGAGGGCCGCGGAGATGGGCGCCTCTGGTGCGCTACCACCTCGAACTTT GACAGCGACAAGAAGTGGGGCTTCTGCCCGGACCAAGGATACAGTTTGTTCCTCGTGGCGGCGCATGAGTTCGGCCACGCGCTGGGCTTA GATCATTCCTCAGTGCCGGAGGCGCTCATGTACCCTATGTACCGCTTCACTGAGGGGCCCCCCTTGCATAAGGACGACGTGAATGGCATC CGGCACCTCTATGGTCCTCGCCCTGAACCTGAGCCACGGCCTCCAACCACCACCACACCGCAGCCCACGGCTCCCCCGACGGTCTGCCCC ACCGGACCCCCCACTGTCCACCCCTCAGAGCGCCCCACAGCTGGCCCCACAGGTCCCCCCTCAGCTGGCCCCACAGGTCCCCCCACTGCT GGCCCTTCTACGGCCACTACTGTGCCTTTGAGTCCGGTGGACGATGCCTGCAACGTGAACATCTTCGACGCCATCGCGGAGATTGGGAAC CAGCTGTATTTGTTCAAGGATGGGAAGTACTGGCGATTCTCTGAGGGCAGGGGGAGCCGGCCGCAGGGCCCCTTCCTTATCGCCGACAAG TGGCCCGCGCTGCCCCGCAAGCTGGACTCGGTCTTTGAGGAGCGGCTCTCCAAGAAGCTTTTCTTCTTCTCTGGGCGCCAGGTGTGGGTG TACACAGGCGCGTCGGTGCTGGGCCCGAGGCGTCTGGACAAGCTGGGCCTGGGAGCCGACGTGGCCCAGGTGACCGGGGCCCTCCGGAGT GGCAGGGGGAAGATGCTGCTGTTCAGCGGGCGGCGCCTCTGGAGGTTCGACGTGAAGGCGCAGATGGTGGATCCCCGGAGCGCCAGCGAG GTGGACCGGATGTTCCCCGGGGTGCCTTTGGACACGCACGACGTCTTCCAGTACCGAGAGAAAGCCTATTTCTGCCAGGACCGCTTCTAC TGGCGCGTGAGTTCCCGGAGTGAGTTGAACCAGGTGGACCAAGTGGGCTACGTGACCTATGACATCCTGCAGTGCCCTGAGGACTAGGGC TCCCGTCCTGCTTTGGCAGTGCCATGTAAATCCCCACTGGGACCAACCCTGGGGAAGGAGCCAGTTTGCCGGATACAAACTGGTATTCTG TTCTGGAGGAAAGGGAGGAGTGGAGGTGGGCTGGGCCCTCTCTTCTCACCTTTGTTTTTTGTTGGAGTGTTTCTAATAAACTTGGATTCT |
Top |
FusionGenePPI for PLEKHA7_MMP9 |
| Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in . |
| Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160) |
| Hgene | Hgene's interactors | Tgene | Tgene's interactors |
| PLEKHA7 | USP20, YWHAQ, LATS2, YWHAB, TSPAN33, FGL1, NINL, CDH1, EGFR, CDC14A, KCTD3, KIF13B, ZBTB21, KSR1, GIGYF1, LRFN1, DENND1A, CGN, SH3PXD2A, SRGAP2, EIF4E2, RTKN, SIPA1L1, MAST3, PPM1H, LIMA1, MAGI1, TESK2, DCLK1, ZNF638, DENND4C, SRSF12, SYDE1, HDAC4, AGAP1, NF1, CDC25B, CDK16, CBY1, MAPKAP1, FAM110B, USP21, NADK, CDC25C, FAM53C, ANKRD34A, GIGYF2, CAMSAP2, TIAM1, KIAA1804, RASAL2, INPP5E | MMP9 | CXCL5, CXCL6, TGFB1, THBS1, THBS2, CLU, COL12A1, TIMP1, COL2A1, COL14A1, COL5A1, COL6A2, COL4A1, FN1, COL4A2, COL6A1, COL18A1, SCARA3 |
| - Retained PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
| - Lost PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
| Hgene | PLEKHA7 | chr11:16872738 | chr20:44638505 | ENST00000355661 | - | 8 | 23 | 538_696 | 232 | 1122 | CTNND1 |
| Hgene | PLEKHA7 | chr11:16872738 | chr20:44638505 | ENST00000448080 | - | 8 | 23 | 538_696 | 232 | 1123 | CTNND1 |
| - Retained PPIs, but lost function due to frame-shift fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
Top |
RelatedDrugs for PLEKHA7_MMP9 |
| Drugs targeting genes involved in this fusion gene. (DrugBank Version 5.1.0 2018-04-02) |
| Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
| Tgene | MMP9 | P14780 | DB01197 | Captopril | Matrix metalloproteinase-9 | small molecule | approved |
| Tgene | MMP9 | P14780 | DB01017 | Minocycline | Matrix metalloproteinase-9 | small molecule | approved|investigational |
| Tgene | MMP9 | P14780 | DB01296 | Glucosamine | Matrix metalloproteinase-9 | small molecule | approved|investigational |
| Tgene | MMP9 | P14780 | DB01593 | Zinc | Matrix metalloproteinase-9 | small molecule | approved|investigational |
| Tgene | MMP9 | P14780 | DB00143 | Glutathione | Matrix metalloproteinase-9 | small molecule | approved|investigational|nutraceutical |
Top |
RelatedDiseases for PLEKHA7_MMP9 |
| Diseases associated with fusion partners. (DisGeNet 4.0) |
| Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
| Hgene | PLEKHA7 | C0017605 | Angle Closure Glaucoma | 2 | CTD_human |
| Tgene | MMP9 | C0027626 | Neoplasm Invasiveness | 7 | CTD_human |
| Tgene | MMP9 | C0027627 | Neoplasm Metastasis | 5 | CTD_human |
| Tgene | MMP9 | C2937358 | Cerebral Hemorrhage | 5 | CTD_human |
| Tgene | MMP9 | C0001973 | Alcoholic Intoxication, Chronic | 3 | PSYGENET |
| Tgene | MMP9 | C0007621 | Neoplastic Cell Transformation | 3 | CTD_human |
| Tgene | MMP9 | C0004096 | Asthma | 2 | CTD_human |
| Tgene | MMP9 | C0005586 | Bipolar Disorder | 2 | PSYGENET |
| Tgene | MMP9 | C0006663 | Calcinosis | 2 | CTD_human |
| Tgene | MMP9 | C0011853 | Diabetes Mellitus, Experimental | 2 | CTD_human |
| Tgene | MMP9 | C0021368 | Inflammation | 2 | CTD_human |
| Tgene | MMP9 | C0023895 | Liver diseases | 2 | CTD_human |
| Tgene | MMP9 | C0027051 | Myocardial Infarction | 2 | CTD_human |
| Tgene | MMP9 | C0031099 | Periodontitis | 2 | CTD_human |
| Tgene | MMP9 | C0036341 | Schizophrenia | 2 | PSYGENET |
| Tgene | MMP9 | C0003486 | Aortic Aneurysm | 1 | CTD_human |
| Tgene | MMP9 | C0003493 | Aortic Diseases | 1 | CTD_human |
| Tgene | MMP9 | C0003496 | Aortic Rupture | 1 | CTD_human |
| Tgene | MMP9 | C0004114 | Astrocytoma | 1 | CTD_human |
| Tgene | MMP9 | C0005967 | Bone neoplasms | 1 | CTD_human |
| Tgene | MMP9 | C0007131 | Non-Small Cell Lung Carcinoma | 1 | CTD_human |
| Tgene | MMP9 | C0007137 | Squamous cell carcinoma | 1 | CTD_human |
| Tgene | MMP9 | C0007786 | Brain Ischemia | 1 | CTD_human |
| Tgene | MMP9 | C0009324 | Ulcerative Colitis | 1 | CTD_human |
| Tgene | MMP9 | C0009375 | Colonic Neoplasms | 1 | CTD_human |
| Tgene | MMP9 | C0011882 | Diabetic Neuropathies | 1 | CTD_human |
| Tgene | MMP9 | C0017636 | Glioblastoma | 1 | CTD_human |
| Tgene | MMP9 | C0020507 | Hyperplasia | 1 | CTD_human |
| Tgene | MMP9 | C0020538 | Hypertensive disease | 1 | CTD_human |
| Tgene | MMP9 | C0023176 | Lead Poisoning | 1 | CTD_human |
| Tgene | MMP9 | C0023893 | Liver Cirrhosis, Experimental | 1 | CTD_human |
| Tgene | MMP9 | C0024117 | Chronic Obstructive Airway Disease | 1 | CTD_human |
| Tgene | MMP9 | C0024143 | Lupus Nephritis | 1 | CTD_human |
| Tgene | MMP9 | C0024668 | Mammary Neoplasms, Experimental | 1 | CTD_human |
| Tgene | MMP9 | C0024796 | Marfan Syndrome | 1 | CTD_human |
| Tgene | MMP9 | C0026552 | Morphine Dependence | 1 | CTD_human |
| Tgene | MMP9 | C0026766 | Multiple Organ Failure | 1 | CTD_human |
| Tgene | MMP9 | C0028754 | Obesity | 1 | CTD_human |
| Tgene | MMP9 | C0029172 | Oral Submucous Fibrosis | 1 | CTD_human |
| Tgene | MMP9 | C0030297 | Pancreatic Neoplasm | 1 | CTD_human |
| Tgene | MMP9 | C0033578 | Prostatic Neoplasms | 1 | CTD_human |
| Tgene | MMP9 | C0034067 | Pulmonary Emphysema | 1 | CTD_human |
| Tgene | MMP9 | C0034069 | Pulmonary Fibrosis | 1 | CTD_human |
| Tgene | MMP9 | C0035126 | Reperfusion Injury | 1 | CTD_human |
| Tgene | MMP9 | C0035309 | Retinal Diseases | 1 | CTD_human |
| Tgene | MMP9 | C0037286 | Skin Neoplasms | 1 | CTD_human |
| Tgene | MMP9 | C0038358 | Gastric ulcer | 1 | CTD_human |
| Tgene | MMP9 | C0038587 | Substance Withdrawal Syndrome | 1 | CTD_human |
| Tgene | MMP9 | C0086132 | Depressive Symptoms | 1 | PSYGENET |
| Tgene | MMP9 | C0151526 | Premature Birth | 1 | CTD_human |
| Tgene | MMP9 | C0162871 | Aortic Aneurysm, Abdominal | 1 | CTD_human |
| Tgene | MMP9 | C0162872 | Aortic Aneurysm, Thoracic | 1 | CTD_human |
| Tgene | MMP9 | C0243026 | Sepsis | 1 | CTD_human |
| Tgene | MMP9 | C0338831 | Manic | 1 | PSYGENET |
| Tgene | MMP9 | C0340288 | Stable angina | 1 | CTD_human |
| Tgene | MMP9 | C0432291 | Mandibuloacral dysostosis | 1 | CTD_human |
| Tgene | MMP9 | C0740392 | Infarction, Middle Cerebral Artery | 1 | CTD_human |
| Tgene | MMP9 | C0948089 | Acute Coronary Syndrome | 1 | CTD_human |
| Tgene | MMP9 | C1458155 | Mammary Neoplasms | 1 | CTD_human |
| Tgene | MMP9 | C1527311 | Brain Edema | 1 | CTD_human |
| Tgene | MMP9 | C2239176 | Liver carcinoma | 1 | CTD_human |
| Tgene | MMP9 | C2936380 | Neointima | 1 | CTD_human |
Copyright 2018-Present -The University of Texas Health Science Center at Houston (UTHealth)
|