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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 27579

FusionGeneSummary for PLEKHA5_CPM

check button Fusion gene summary
Fusion gene informationFusion gene name: PLEKHA5_CPM
Fusion gene ID: 27579
HgeneTgene
Gene symbol

PLEKHA5

CPM

Gene ID

54477

1368

Gene namepleckstrin homology domain containing A5carboxypeptidase M
SynonymsPEPP-2|PEPP2-
Cytomap

12p12.3

12q15

Type of geneprotein-codingprotein-coding
Descriptionpleckstrin homology domain-containing family A member 5PH domain-containing family A member 5phosphoinositol 3-phosphate-binding protein-2pleckstrin homology domain containing, family A member 5carboxypeptidase Mrenal carboxypeptidaseurinary carboxypeptidase B
Modification date2018051920180523
UniProtAcc

Q9HAU0

P14384

Ensembl transtripts involved in fusion geneENST00000309364, ENST00000359180, 
ENST00000317589, ENST00000355397, 
ENST00000429027, ENST00000539256, 
ENST00000299275, ENST00000538714, 
ENST00000543806, ENST00000424268, 
ENST00000540972, ENST00000510738, 
ENST00000546373, ENST00000551568, 
ENST00000338356, ENST00000549691, 
Fusion gene scores* DoF score13 X 7 X 10=91038 X 10 X 8=3040
# samples 1335
** MAII scorelog2(13/910*10)=-2.8073549220576
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
log2(35/3040*10)=-3.11864449649862
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: PLEKHA5 [Title/Abstract] AND CPM [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID

check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
TCGALDSARCTCGA-DX-A1L3-01APLEKHA5chr12

19475601

+CPMchr12

69351458

-
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
intron-intronENST00000309364ENST00000546373PLEKHA5chr12

19475601

+CPMchr12

69351458

-
intron-intronENST00000309364ENST00000551568PLEKHA5chr12

19475601

+CPMchr12

69351458

-
intron-intronENST00000309364ENST00000338356PLEKHA5chr12

19475601

+CPMchr12

69351458

-
intron-5UTRENST00000309364ENST00000549691PLEKHA5chr12

19475601

+CPMchr12

69351458

-
5CDS-intronENST00000359180ENST00000546373PLEKHA5chr12

19475601

+CPMchr12

69351458

-
5CDS-intronENST00000359180ENST00000551568PLEKHA5chr12

19475601

+CPMchr12

69351458

-
5CDS-intronENST00000359180ENST00000338356PLEKHA5chr12

19475601

+CPMchr12

69351458

-
5CDS-5UTRENST00000359180ENST00000549691PLEKHA5chr12

19475601

+CPMchr12

69351458

-
5CDS-intronENST00000317589ENST00000546373PLEKHA5chr12

19475601

+CPMchr12

69351458

-
5CDS-intronENST00000317589ENST00000551568PLEKHA5chr12

19475601

+CPMchr12

69351458

-
5CDS-intronENST00000317589ENST00000338356PLEKHA5chr12

19475601

+CPMchr12

69351458

-
5CDS-5UTRENST00000317589ENST00000549691PLEKHA5chr12

19475601

+CPMchr12

69351458

-
5CDS-intronENST00000355397ENST00000546373PLEKHA5chr12

19475601

+CPMchr12

69351458

-
5CDS-intronENST00000355397ENST00000551568PLEKHA5chr12

19475601

+CPMchr12

69351458

-
5CDS-intronENST00000355397ENST00000338356PLEKHA5chr12

19475601

+CPMchr12

69351458

-
5CDS-5UTRENST00000355397ENST00000549691PLEKHA5chr12

19475601

+CPMchr12

69351458

-
5CDS-intronENST00000429027ENST00000546373PLEKHA5chr12

19475601

+CPMchr12

69351458

-
5CDS-intronENST00000429027ENST00000551568PLEKHA5chr12

19475601

+CPMchr12

69351458

-
5CDS-intronENST00000429027ENST00000338356PLEKHA5chr12

19475601

+CPMchr12

69351458

-
5CDS-5UTRENST00000429027ENST00000549691PLEKHA5chr12

19475601

+CPMchr12

69351458

-
5CDS-intronENST00000539256ENST00000546373PLEKHA5chr12

19475601

+CPMchr12

69351458

-
5CDS-intronENST00000539256ENST00000551568PLEKHA5chr12

19475601

+CPMchr12

69351458

-
5CDS-intronENST00000539256ENST00000338356PLEKHA5chr12

19475601

+CPMchr12

69351458

-
5CDS-5UTRENST00000539256ENST00000549691PLEKHA5chr12

19475601

+CPMchr12

69351458

-
5CDS-intronENST00000299275ENST00000546373PLEKHA5chr12

19475601

+CPMchr12

69351458

-
5CDS-intronENST00000299275ENST00000551568PLEKHA5chr12

19475601

+CPMchr12

69351458

-
5CDS-intronENST00000299275ENST00000338356PLEKHA5chr12

19475601

+CPMchr12

69351458

-
5CDS-5UTRENST00000299275ENST00000549691PLEKHA5chr12

19475601

+CPMchr12

69351458

-
5CDS-intronENST00000538714ENST00000546373PLEKHA5chr12

19475601

+CPMchr12

69351458

-
5CDS-intronENST00000538714ENST00000551568PLEKHA5chr12

19475601

+CPMchr12

69351458

-
5CDS-intronENST00000538714ENST00000338356PLEKHA5chr12

19475601

+CPMchr12

69351458

-
5CDS-5UTRENST00000538714ENST00000549691PLEKHA5chr12

19475601

+CPMchr12

69351458

-
5CDS-intronENST00000543806ENST00000546373PLEKHA5chr12

19475601

+CPMchr12

69351458

-
5CDS-intronENST00000543806ENST00000551568PLEKHA5chr12

19475601

+CPMchr12

69351458

-
5CDS-intronENST00000543806ENST00000338356PLEKHA5chr12

19475601

+CPMchr12

69351458

-
5CDS-5UTRENST00000543806ENST00000549691PLEKHA5chr12

19475601

+CPMchr12

69351458

-
5CDS-intronENST00000424268ENST00000546373PLEKHA5chr12

19475601

+CPMchr12

69351458

-
5CDS-intronENST00000424268ENST00000551568PLEKHA5chr12

19475601

+CPMchr12

69351458

-
5CDS-intronENST00000424268ENST00000338356PLEKHA5chr12

19475601

+CPMchr12

69351458

-
5CDS-5UTRENST00000424268ENST00000549691PLEKHA5chr12

19475601

+CPMchr12

69351458

-
intron-intronENST00000540972ENST00000546373PLEKHA5chr12

19475601

+CPMchr12

69351458

-
intron-intronENST00000540972ENST00000551568PLEKHA5chr12

19475601

+CPMchr12

69351458

-
intron-intronENST00000540972ENST00000338356PLEKHA5chr12

19475601

+CPMchr12

69351458

-
intron-5UTRENST00000540972ENST00000549691PLEKHA5chr12

19475601

+CPMchr12

69351458

-
intron-intronENST00000510738ENST00000546373PLEKHA5chr12

19475601

+CPMchr12

69351458

-
intron-intronENST00000510738ENST00000551568PLEKHA5chr12

19475601

+CPMchr12

69351458

-
intron-intronENST00000510738ENST00000338356PLEKHA5chr12

19475601

+CPMchr12

69351458

-
intron-5UTRENST00000510738ENST00000549691PLEKHA5chr12

19475601

+CPMchr12

69351458

-

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FusionProtFeatures for PLEKHA5_CPM


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
PLEKHA5

Q9HAU0

CPM

P14384

Specifically removes C-terminal basic residues (Arg orLys) from peptides and proteins. It is believed to play importantroles in the control of peptide hormone and growth factor activityat the cell surface, and in the membrane-localized degradation ofextracellular proteins. {ECO:0000269|PubMed:12457462}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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FusionGeneSequence for PLEKHA5_CPM


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for PLEKHA5_CPM


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors
PLEKHA5DES, EVPL, EXTL3, KRT19, KTN1, LAMB2, PLEC, SPTAN1, SPTBN1, PROM1, CEP350, KIF3A, CEP250, PLEKHA6, ARHGEF9, PPP1R13B, BLOC1S6, KRT20, MAX, PLEKHA5, CCDC186, CCDC92, SH3BP5L, CCDC88B, KANSL1, SOGA1, WASH2P, ELAVL1, SH3KBP1, LSM4, UPF1, LATS2, YWHAB, CIAO1, AURKB, PDZD11, FHL3, GINM1, SRPK2, KIAA0753, SPICE1, DCTN1, DYNLT1, POC1A, TMEM17, XPO1, CLTC, HIF1A, KIF11, PPP2CB, PPP2R1A, SEC16A, CDH1, SSSCA1, IL17RA, KCTD3, KIF13B, ZBTB21, KSR1, GIGYF1, LRFN1, DENND1A, SH3PXD2A, SRGAP2, EIF4E2, SIPA1L1, LIMA1, MAGI1, TESK2, DCLK1, ZNF638, SRSF12, SYDE1, AGAP1, MAST3, RTKN, PPM1H, CDC25B, CDK16, CBY1, RAB3IPCPMELAVL1, CAPZA2, DBN1, FLNA, GAK, MYH9, PPP1CC, RAB7A, PDLIM7, ATP6AP2, SYNPO, MAPRE1, GOLT1B, LIMA1, ANLN, MYO19, ZSCAN12, ULBP1, FTH1, TBC1D22B, GTPBP3


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for PLEKHA5_CPM


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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RelatedDiseases for PLEKHA5_CPM


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
TgeneCPMC0014175Endometriosis1CTD_human
TgeneCPMC0037116Silicosis1CTD_human