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Fusion gene ID: 27579 |
FusionGeneSummary for PLEKHA5_CPM |
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Fusion gene information | Fusion gene name: PLEKHA5_CPM | Fusion gene ID: 27579 | Hgene | Tgene | Gene symbol | PLEKHA5 | CPM | Gene ID | 54477 | 1368 |
Gene name | pleckstrin homology domain containing A5 | carboxypeptidase M | |
Synonyms | PEPP-2|PEPP2 | - | |
Cytomap | 12p12.3 | 12q15 | |
Type of gene | protein-coding | protein-coding | |
Description | pleckstrin homology domain-containing family A member 5PH domain-containing family A member 5phosphoinositol 3-phosphate-binding protein-2pleckstrin homology domain containing, family A member 5 | carboxypeptidase Mrenal carboxypeptidaseurinary carboxypeptidase B | |
Modification date | 20180519 | 20180523 | |
UniProtAcc | Q9HAU0 | P14384 | |
Ensembl transtripts involved in fusion gene | ENST00000309364, ENST00000359180, ENST00000317589, ENST00000355397, ENST00000429027, ENST00000539256, ENST00000299275, ENST00000538714, ENST00000543806, ENST00000424268, ENST00000540972, ENST00000510738, | ENST00000546373, ENST00000551568, ENST00000338356, ENST00000549691, | |
Fusion gene scores | * DoF score | 13 X 7 X 10=910 | 38 X 10 X 8=3040 |
# samples | 13 | 35 | |
** MAII score | log2(13/910*10)=-2.8073549220576 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | log2(35/3040*10)=-3.11864449649862 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | |
Context | PubMed: PLEKHA5 [Title/Abstract] AND CPM [Title/Abstract] AND fusion [Title/Abstract] | ||
Functional or gene categories assigned by FusionGDB annotation |
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
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Partner | Gene | GO ID | GO term | PubMed ID |
![]() (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
TCGA | LD | SARC | TCGA-DX-A1L3-01A | PLEKHA5 | chr12 | 19475601 | + | CPM | chr12 | 69351458 | - |
* LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
![]() * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
intron-intron | ENST00000309364 | ENST00000546373 | PLEKHA5 | chr12 | 19475601 | + | CPM | chr12 | 69351458 | - |
intron-intron | ENST00000309364 | ENST00000551568 | PLEKHA5 | chr12 | 19475601 | + | CPM | chr12 | 69351458 | - |
intron-intron | ENST00000309364 | ENST00000338356 | PLEKHA5 | chr12 | 19475601 | + | CPM | chr12 | 69351458 | - |
intron-5UTR | ENST00000309364 | ENST00000549691 | PLEKHA5 | chr12 | 19475601 | + | CPM | chr12 | 69351458 | - |
5CDS-intron | ENST00000359180 | ENST00000546373 | PLEKHA5 | chr12 | 19475601 | + | CPM | chr12 | 69351458 | - |
5CDS-intron | ENST00000359180 | ENST00000551568 | PLEKHA5 | chr12 | 19475601 | + | CPM | chr12 | 69351458 | - |
5CDS-intron | ENST00000359180 | ENST00000338356 | PLEKHA5 | chr12 | 19475601 | + | CPM | chr12 | 69351458 | - |
5CDS-5UTR | ENST00000359180 | ENST00000549691 | PLEKHA5 | chr12 | 19475601 | + | CPM | chr12 | 69351458 | - |
5CDS-intron | ENST00000317589 | ENST00000546373 | PLEKHA5 | chr12 | 19475601 | + | CPM | chr12 | 69351458 | - |
5CDS-intron | ENST00000317589 | ENST00000551568 | PLEKHA5 | chr12 | 19475601 | + | CPM | chr12 | 69351458 | - |
5CDS-intron | ENST00000317589 | ENST00000338356 | PLEKHA5 | chr12 | 19475601 | + | CPM | chr12 | 69351458 | - |
5CDS-5UTR | ENST00000317589 | ENST00000549691 | PLEKHA5 | chr12 | 19475601 | + | CPM | chr12 | 69351458 | - |
5CDS-intron | ENST00000355397 | ENST00000546373 | PLEKHA5 | chr12 | 19475601 | + | CPM | chr12 | 69351458 | - |
5CDS-intron | ENST00000355397 | ENST00000551568 | PLEKHA5 | chr12 | 19475601 | + | CPM | chr12 | 69351458 | - |
5CDS-intron | ENST00000355397 | ENST00000338356 | PLEKHA5 | chr12 | 19475601 | + | CPM | chr12 | 69351458 | - |
5CDS-5UTR | ENST00000355397 | ENST00000549691 | PLEKHA5 | chr12 | 19475601 | + | CPM | chr12 | 69351458 | - |
5CDS-intron | ENST00000429027 | ENST00000546373 | PLEKHA5 | chr12 | 19475601 | + | CPM | chr12 | 69351458 | - |
5CDS-intron | ENST00000429027 | ENST00000551568 | PLEKHA5 | chr12 | 19475601 | + | CPM | chr12 | 69351458 | - |
5CDS-intron | ENST00000429027 | ENST00000338356 | PLEKHA5 | chr12 | 19475601 | + | CPM | chr12 | 69351458 | - |
5CDS-5UTR | ENST00000429027 | ENST00000549691 | PLEKHA5 | chr12 | 19475601 | + | CPM | chr12 | 69351458 | - |
5CDS-intron | ENST00000539256 | ENST00000546373 | PLEKHA5 | chr12 | 19475601 | + | CPM | chr12 | 69351458 | - |
5CDS-intron | ENST00000539256 | ENST00000551568 | PLEKHA5 | chr12 | 19475601 | + | CPM | chr12 | 69351458 | - |
5CDS-intron | ENST00000539256 | ENST00000338356 | PLEKHA5 | chr12 | 19475601 | + | CPM | chr12 | 69351458 | - |
5CDS-5UTR | ENST00000539256 | ENST00000549691 | PLEKHA5 | chr12 | 19475601 | + | CPM | chr12 | 69351458 | - |
5CDS-intron | ENST00000299275 | ENST00000546373 | PLEKHA5 | chr12 | 19475601 | + | CPM | chr12 | 69351458 | - |
5CDS-intron | ENST00000299275 | ENST00000551568 | PLEKHA5 | chr12 | 19475601 | + | CPM | chr12 | 69351458 | - |
5CDS-intron | ENST00000299275 | ENST00000338356 | PLEKHA5 | chr12 | 19475601 | + | CPM | chr12 | 69351458 | - |
5CDS-5UTR | ENST00000299275 | ENST00000549691 | PLEKHA5 | chr12 | 19475601 | + | CPM | chr12 | 69351458 | - |
5CDS-intron | ENST00000538714 | ENST00000546373 | PLEKHA5 | chr12 | 19475601 | + | CPM | chr12 | 69351458 | - |
5CDS-intron | ENST00000538714 | ENST00000551568 | PLEKHA5 | chr12 | 19475601 | + | CPM | chr12 | 69351458 | - |
5CDS-intron | ENST00000538714 | ENST00000338356 | PLEKHA5 | chr12 | 19475601 | + | CPM | chr12 | 69351458 | - |
5CDS-5UTR | ENST00000538714 | ENST00000549691 | PLEKHA5 | chr12 | 19475601 | + | CPM | chr12 | 69351458 | - |
5CDS-intron | ENST00000543806 | ENST00000546373 | PLEKHA5 | chr12 | 19475601 | + | CPM | chr12 | 69351458 | - |
5CDS-intron | ENST00000543806 | ENST00000551568 | PLEKHA5 | chr12 | 19475601 | + | CPM | chr12 | 69351458 | - |
5CDS-intron | ENST00000543806 | ENST00000338356 | PLEKHA5 | chr12 | 19475601 | + | CPM | chr12 | 69351458 | - |
5CDS-5UTR | ENST00000543806 | ENST00000549691 | PLEKHA5 | chr12 | 19475601 | + | CPM | chr12 | 69351458 | - |
5CDS-intron | ENST00000424268 | ENST00000546373 | PLEKHA5 | chr12 | 19475601 | + | CPM | chr12 | 69351458 | - |
5CDS-intron | ENST00000424268 | ENST00000551568 | PLEKHA5 | chr12 | 19475601 | + | CPM | chr12 | 69351458 | - |
5CDS-intron | ENST00000424268 | ENST00000338356 | PLEKHA5 | chr12 | 19475601 | + | CPM | chr12 | 69351458 | - |
5CDS-5UTR | ENST00000424268 | ENST00000549691 | PLEKHA5 | chr12 | 19475601 | + | CPM | chr12 | 69351458 | - |
intron-intron | ENST00000540972 | ENST00000546373 | PLEKHA5 | chr12 | 19475601 | + | CPM | chr12 | 69351458 | - |
intron-intron | ENST00000540972 | ENST00000551568 | PLEKHA5 | chr12 | 19475601 | + | CPM | chr12 | 69351458 | - |
intron-intron | ENST00000540972 | ENST00000338356 | PLEKHA5 | chr12 | 19475601 | + | CPM | chr12 | 69351458 | - |
intron-5UTR | ENST00000540972 | ENST00000549691 | PLEKHA5 | chr12 | 19475601 | + | CPM | chr12 | 69351458 | - |
intron-intron | ENST00000510738 | ENST00000546373 | PLEKHA5 | chr12 | 19475601 | + | CPM | chr12 | 69351458 | - |
intron-intron | ENST00000510738 | ENST00000551568 | PLEKHA5 | chr12 | 19475601 | + | CPM | chr12 | 69351458 | - |
intron-intron | ENST00000510738 | ENST00000338356 | PLEKHA5 | chr12 | 19475601 | + | CPM | chr12 | 69351458 | - |
intron-5UTR | ENST00000510738 | ENST00000549691 | PLEKHA5 | chr12 | 19475601 | + | CPM | chr12 | 69351458 | - |
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FusionProtFeatures for PLEKHA5_CPM |
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Hgene | Tgene |
PLEKHA5 | CPM |
Specifically removes C-terminal basic residues (Arg orLys) from peptides and proteins. It is believed to play importantroles in the control of peptide hormone and growth factor activityat the cell surface, and in the membrane-localized degradation ofextracellular proteins. {ECO:0000269|PubMed:12457462}. |
![]() * Minus value of BPloci means that the break pointn is located before the CDS. |
- In-frame and retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
- In-frame and not-retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
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FusionGeneSequence for PLEKHA5_CPM |
![]() (nt: nucleotides, aa: amino acids) |
* Fusion amino acid sequences. |
* Fusion transcript sequences (only coding sequence (CDS) region). |
* Fusion transcript sequences (Full-length transcript). |
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FusionGenePPI for PLEKHA5_CPM |
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Hgene | Hgene's interactors | Tgene | Tgene's interactors |
PLEKHA5 | DES, EVPL, EXTL3, KRT19, KTN1, LAMB2, PLEC, SPTAN1, SPTBN1, PROM1, CEP350, KIF3A, CEP250, PLEKHA6, ARHGEF9, PPP1R13B, BLOC1S6, KRT20, MAX, PLEKHA5, CCDC186, CCDC92, SH3BP5L, CCDC88B, KANSL1, SOGA1, WASH2P, ELAVL1, SH3KBP1, LSM4, UPF1, LATS2, YWHAB, CIAO1, AURKB, PDZD11, FHL3, GINM1, SRPK2, KIAA0753, SPICE1, DCTN1, DYNLT1, POC1A, TMEM17, XPO1, CLTC, HIF1A, KIF11, PPP2CB, PPP2R1A, SEC16A, CDH1, SSSCA1, IL17RA, KCTD3, KIF13B, ZBTB21, KSR1, GIGYF1, LRFN1, DENND1A, SH3PXD2A, SRGAP2, EIF4E2, SIPA1L1, LIMA1, MAGI1, TESK2, DCLK1, ZNF638, SRSF12, SYDE1, AGAP1, MAST3, RTKN, PPM1H, CDC25B, CDK16, CBY1, RAB3IP | CPM | ELAVL1, CAPZA2, DBN1, FLNA, GAK, MYH9, PPP1CC, RAB7A, PDLIM7, ATP6AP2, SYNPO, MAPRE1, GOLT1B, LIMA1, ANLN, MYO19, ZSCAN12, ULBP1, FTH1, TBC1D22B, GTPBP3 |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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RelatedDrugs for PLEKHA5_CPM |
![]() (DrugBank Version 5.1.0 2018-04-02) |
Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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RelatedDiseases for PLEKHA5_CPM |
![]() (DisGeNet 4.0) |
Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
Tgene | CPM | C0014175 | Endometriosis | 1 | CTD_human |
Tgene | CPM | C0037116 | Silicosis | 1 | CTD_human |