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Fusion gene ID: 27572 |
FusionGeneSummary for PLEKHA2_KCNU1 |
 Fusion gene summary |
| Fusion gene information | Fusion gene name: PLEKHA2_KCNU1 | Fusion gene ID: 27572 | Hgene | Tgene | Gene symbol | PLEKHA2 | KCNU1 | Gene ID | 59339 | 157855 |
| Gene name | pleckstrin homology domain containing A2 | potassium calcium-activated channel subfamily U member 1 | |
| Synonyms | TAPP2 | KCNMC1|KCa5|KCa5.1|Kcnma3|Slo3 | |
| Cytomap | 8p11.22 | 8p11.23 | |
| Type of gene | protein-coding | protein-coding | |
| Description | pleckstrin homology domain-containing family A member 2PH domain-containing family A member 2TAPP-2pleckstrin homology domain containing, family A (phosphoinositide binding specific) member 2tandem PH Domain containing protein-2tandem PH domain-conta | potassium channel subfamily U member 1Calcium-activated potassium channel subunit alpha-3Calcium-activated potassium channel, subfamily M subunit alpha-3Slowpoke homolog 3potassium channel, subfamily U, member 1 | |
| Modification date | 20180523 | 20180523 | |
| UniProtAcc | Q9HB19 | A8MYU2 | |
| Ensembl transtripts involved in fusion gene | ENST00000521746, ENST00000420274, ENST00000388745, | ENST00000399881, ENST00000518904, | |
| Fusion gene scores | * DoF score | 7 X 6 X 5=210 | 7 X 4 X 7=196 |
| # samples | 8 | 8 | |
| ** MAII score | log2(8/210*10)=-1.39231742277876 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | log2(8/196*10)=-1.29278174922785 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | |
| Context | PubMed: PLEKHA2 [Title/Abstract] AND KCNU1 [Title/Abstract] AND fusion [Title/Abstract] | ||
| Functional or gene categories assigned by FusionGDB annotation | |||
| * DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
| Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Partner | Gene | GO ID | GO term | PubMed ID |
| Fusion gene information from three resources (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| TCGA | RV | BRCA | TCGA-C8-A12X-01A | PLEKHA2 | chr8 | 38759410 | + | KCNU1 | chr8 | 36793033 | + |
| TCGA | RV | UCEC | TCGA-K6-A3WQ-01A | PLEKHA2 | chr8 | 38814904 | + | KCNU1 | chr8 | 36663787 | + |
| * LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
| Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| intron-3CDS | ENST00000521746 | ENST00000399881 | PLEKHA2 | chr8 | 38759410 | + | KCNU1 | chr8 | 36793033 | + |
| intron-intron | ENST00000521746 | ENST00000518904 | PLEKHA2 | chr8 | 38759410 | + | KCNU1 | chr8 | 36793033 | + |
| intron-3CDS | ENST00000420274 | ENST00000399881 | PLEKHA2 | chr8 | 38759410 | + | KCNU1 | chr8 | 36793033 | + |
| intron-intron | ENST00000420274 | ENST00000518904 | PLEKHA2 | chr8 | 38759410 | + | KCNU1 | chr8 | 36793033 | + |
| intron-3CDS | ENST00000388745 | ENST00000399881 | PLEKHA2 | chr8 | 38759410 | + | KCNU1 | chr8 | 36793033 | + |
| intron-intron | ENST00000388745 | ENST00000518904 | PLEKHA2 | chr8 | 38759410 | + | KCNU1 | chr8 | 36793033 | + |
| intron-3CDS | ENST00000521746 | ENST00000399881 | PLEKHA2 | chr8 | 38814904 | + | KCNU1 | chr8 | 36663787 | + |
| intron-intron | ENST00000521746 | ENST00000518904 | PLEKHA2 | chr8 | 38814904 | + | KCNU1 | chr8 | 36663787 | + |
| In-frame | ENST00000420274 | ENST00000399881 | PLEKHA2 | chr8 | 38814904 | + | KCNU1 | chr8 | 36663787 | + |
| 5CDS-intron | ENST00000420274 | ENST00000518904 | PLEKHA2 | chr8 | 38814904 | + | KCNU1 | chr8 | 36663787 | + |
| 3UTR-3CDS | ENST00000388745 | ENST00000399881 | PLEKHA2 | chr8 | 38814904 | + | KCNU1 | chr8 | 36663787 | + |
| 3UTR-intron | ENST00000388745 | ENST00000518904 | PLEKHA2 | chr8 | 38814904 | + | KCNU1 | chr8 | 36663787 | + |
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FusionProtFeatures for PLEKHA2_KCNU1 |
| Main function of each fusion partner protein. (from UniProt) |
| Hgene | Tgene |
| PLEKHA2 | KCNU1 |
| Binds specifically to phosphatidylinositol 3,4-diphosphate (PtdIns3,4P2), but not to other phosphoinositides. Mayrecruit other proteins to the plasma membrane (By similarity).{ECO:0000250}. | Testis-specific potassium channel activated by bothintracellular pH and membrane voltage that mediates export ofK(+). May represent the primary spermatozoan K(+) current. Incontrast to KCNMA1/SLO1, it is not activated by Ca(2+) or Mg(2+).Critical for fertility. May play an important role in spermosmoregulation required for the acquisition of normal morphologyand motility when faced with osmotic challenges, such as thoseexperienced after mixing with seminal fluid and entry into thevagina. {ECO:0000269|PubMed:23129643}. |
| Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at . * Minus value of BPloci means that the break pointn is located before the CDS. |
| - In-frame and retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
| - In-frame and not-retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
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FusionGeneSequence for PLEKHA2_KCNU1 |
| For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. (nt: nucleotides, aa: amino acids) |
| * Fusion amino acid sequences. |
| >In-frame_PLEKHA2_ENST00000420274_chr8_38814904_+_KCNU1_ENST00000399881_chr8_36663787_+_1273aa MPYVDRQNRICGFLDIEEHENSGKFLRRYFILDTQANCLLWYMDNPQNLAMGAGAVGALQLTYISKVSIATPKQKPKTPFCFVINALSQR YFLQANDQKDMKDWVEALNQASKITVPKGGGLPMTTEVLKSLAAPPALEKKPQVAYKTEIIGGVVVHTPISQNGGDGQEGSEPGSHTILR RSQSYIPTSGCRASTGPPLIKSGYCVKQGNVRKSWKRRFFALDDFTICYFKCEQDREPLRTIFLKDVLKTHECLVKSGDLLMRDNLFEII TSSRTFYVQFMAADDKIKFWLEMNSIVDIFTIPPTFISYYLKSNWLGLRFLRALRLLELPQILQILRAIKTSNSVKFSKLLSIILSTWFT AAGFIHLVENSGDPWLKGRNSQNISYFESIYLVMATTSTVGFGDVVAKTSLGRTFIMFFTLGSLILFANYIPEMVELFANKRKYTSSYEA LKGKKFIVVCGNITVDSVTAFLRNFLRDKSGEINTEIVFLGETPPSLELETIFKCYLAYTTFISGSAMKWEDLRRVAVESAEACLIIANP LCSDSHAEDISNIMRVLSIKNYDSTTRIIIQILQSHNKVYLPKIPSWNWDTGDNIICFAELKLGFIAQGCLVPGLCTFLTSLFVEQNKKV MPKQTWKKHFLNSMKNKILTQRLSDDFAGMSFPEVARLCFLKMHLLLIAIEYKSLFTDGFCGLILNPPPQVRIRKNTLGFFIAETPKDVR RALFYCSVCHDDVFIPELITNCGCKSRSRQHITVPSVKRMKKCLKGISSRISGQDSPPRVSASTSSISNFTTRTLQHDVEQDSDQLDSSG MFHWCKPTSLDKVTLKRTGKSKYKFRNHIVACVFGDAHSAPMGLRNFVMPLRASNYTRKELKDIVFIGSLDYLQREWRFLWNFPQIYILP GCALYSGDLHAANIEQCSMCAVLSPPPQPSSNQTLVDTEAIMATLTIGSLQIDSSSDPSPSVSEETPGYTNGHNEKSNCRKVPILTELKN PSNIHFIEQLGGLEGSLQETNLHLSTAFSTGTVFSGSFLDSLLATAFYNYHVLELLQMLVTGGVSSQLEQHLDKDKVYGVADSCTSLLSG RNRCKLGLLSLHETILSDVNPRNTFGQLFCGSLDLFGILCVGLYRIIDEEELNPENKRFVITRPANEFKLLPSDLVFCAIPFSTACYKRN EEFSLQKSYEIVNKASQTTETHSDTNCPPTIDSVTETLYSPVYSYQPRTNSLSFPKQIAWNQSRTNSIISSQIPLGDNAKENERKTSDEV |
| * Fusion transcript sequences (only coding sequence (CDS) region). |
| >In-frame_PLEKHA2_ENST00000420274_chr8_38814904_+_KCNU1_ENST00000399881_chr8_36663787_+_3819nt ATGCCTTATGTGGATCGGCAGAACCGAATCTGTGGGTTTCTGGACATCGAGGAGCATGAGAACAGCGGCAAGTTTCTGCGGAGGTACTTC ATTCTGGACACCCAGGCTAACTGCCTCCTCTGGTATATGGACAACCCCCAGAATCTGGCAATGGGGGCAGGAGCTGTTGGAGCTTTGCAG CTGACCTACATCTCGAAGGTGAGCATAGCTACCCCAAAACAGAAACCAAAAACTCCATTTTGCTTTGTTATCAATGCCCTGTCTCAGAGA TATTTCCTTCAAGCCAATGATCAGAAAGATATGAAGGACTGGGTTGAAGCCCTGAACCAAGCCAGCAAGATCACCGTTCCCAAAGGTGGG GGCCTACCCATGACCACTGAAGTTCTCAAGAGCTTAGCAGCTCCTCCAGCCCTGGAGAAGAAGCCACAGGTGGCCTACAAGACGGAGATC ATTGGAGGGGTGGTGGTCCACACACCCATCAGCCAGAACGGTGGGGATGGGCAGGAAGGGAGTGAGCCCGGGTCCCACACCATCCTTCGA AGGTCTCAGAGTTACATCCCCACGTCAGGCTGCCGTGCTTCCACTGGGCCTCCCCTCATTAAGAGTGGTTACTGCGTGAAGCAAGGGAAT GTGCGGAAGAGCTGGAAACGTCGCTTCTTTGCACTTGATGACTTTACCATCTGCTACTTCAAGTGTGAGCAGGACCGAGAACCACTGCGC ACCATATTTCTTAAGGATGTTCTGAAGACCCATGAATGTCTGGTCAAGTCTGGTGATCTCTTAATGAGGGACAACCTGTTTGAAATAATA ACAAGCTCCAGGACCTTCTACGTACAGTTTATGGCAGCTGATGACAAGATCAAGTTCTGGCTGGAGATGAATTCAATCGTAGACATCTTT ACCATCCCACCAACCTTTATTTCTTATTATTTGAAGAGCAATTGGCTAGGTTTAAGGTTCCTAAGAGCCTTGCGCCTGCTAGAACTCCCT CAAATCTTGCAAATTCTACGAGCCATCAAGACCAGTAACTCAGTGAAGTTTTCCAAACTGCTGTCAATAATTCTCAGTACCTGGTTCACA GCTGCGGGATTCATTCACCTGGTGGAAAATTCTGGTGATCCCTGGCTCAAAGGTAGAAATTCACAGAATATATCATATTTTGAGTCAATT TACCTGGTCATGGCAACAACGTCAACCGTTGGATTTGGAGATGTGGTAGCCAAGACATCCTTAGGACGGACCTTCATCATGTTCTTCACA CTGGGGAGTTTGATATTATTTGCGAACTATATACCTGAAATGGTGGAACTGTTTGCTAACAAGAGGAAATACACCAGTTCCTATGAAGCA CTCAAAGGAAAGAAGTTTATTGTGGTCTGTGGAAACATCACTGTGGACAGTGTGACCGCTTTCCTGAGGAATTTCCTCCGCGACAAGTCA GGAGAGATCAACACTGAAATTGTTTTCCTGGGAGAAACCCCTCCTTCTTTGGAACTTGAAACCATATTTAAATGCTACTTGGCCTACACA ACGTTCATTTCTGGATCTGCAATGAAGTGGGAGGATCTGAGGCGAGTTGCGGTGGAATCTGCAGAGGCATGCCTGATTATAGCCAATCCT TTGTGCAGTGATTCCCATGCTGAAGATATTTCCAACATTATGAGGGTGCTCTCTATCAAGAACTATGATTCTACCACCAGAATCATCATA CAGATACTGCAATCCCATAACAAGGTTTATCTGCCAAAGATTCCCAGCTGGAACTGGGACACCGGAGACAACATCATCTGCTTTGCTGAA TTAAAACTTGGATTTATCGCCCAAGGCTGTTTGGTGCCAGGCTTGTGTACCTTCCTAACATCTCTATTTGTGGAGCAAAACAAAAAGGTT ATGCCTAAACAGACCTGGAAGAAACACTTCTTGAATAGCATGAAAAACAAAATTCTGACCCAACGTCTCTCTGATGACTTTGCTGGAATG AGCTTTCCTGAAGTTGCCCGGCTCTGCTTTCTGAAGATGCACCTCCTGTTGATAGCCATCGAATACAAGTCCCTCTTTACGGATGGTTTC TGTGGTCTGATACTAAATCCACCTCCACAAGTGAGGATACGTAAGAACACATTAGGGTTCTTTATTGCTGAAACTCCAAAGGACGTCAGA AGAGCCTTGTTTTACTGTTCAGTCTGTCATGATGATGTGTTCATTCCTGAGCTAATTACAAACTGTGGCTGCAAAAGCAGAAGCCGGCAG CACATCACAGTGCCATCGGTAAAGAGAATGAAAAAATGTCTGAAGGGAATCTCCTCTCGTATATCAGGGCAGGATTCTCCGCCAAGGGTA TCTGCAAGCACTTCGAGCATATCAAACTTCACCACCAGGACTCTTCAACATGATGTAGAACAAGATTCTGACCAGCTTGATAGCAGTGGG ATGTTTCACTGGTGCAAACCAACCTCTTTGGACAAGGTGACTCTGAAACGAACTGGCAAGTCAAAGTATAAGTTTCGGAACCATATTGTA GCATGTGTATTTGGAGATGCCCACTCAGCCCCGATGGGGCTTCGGAACTTTGTAATGCCCTTGAGAGCCAGCAACTATACCAGGAAGGAG CTGAAGGACATAGTGTTCATTGGGTCTCTGGACTATCTACAGAGAGAATGGCGATTTCTCTGGAATTTTCCCCAGATATACATTCTGCCT GGATGTGCACTTTATTCTGGAGACCTCCATGCGGCCAACATAGAGCAATGCTCCATGTGTGCTGTCTTGTCCCCCCCACCCCAGCCATCA AGCAACCAGACTTTGGTAGACACAGAAGCCATCATGGCAACCCTCACCATCGGATCCTTGCAAATTGACTCCTCCTCTGACCCGTCACCC TCAGTGTCAGAGGAGACTCCAGGTTACACAAATGGACATAATGAGAAATCAAACTGCCGAAAAGTCCCTATCCTTACTGAACTGAAAAAT CCTTCCAACATTCACTTTATTGAACAGCTTGGTGGACTGGAAGGGTCCCTCCAAGAAACAAATCTGCATCTCAGCACTGCCTTTTCTACG GGCACTGTTTTTTCCGGCAGCTTCTTGGATTCTCTGCTGGCCACGGCCTTCTACAATTATCATGTCCTGGAATTGCTTCAGATGCTGGTG ACAGGAGGAGTAAGTTCTCAGCTGGAACAACATTTAGATAAGGATAAAGTCTATGGTGTGGCAGATAGCTGCACGTCGCTCTTGTCTGGA AGAAACCGGTGTAAGCTGGGGCTTCTGTCCTTACACGAAACCATTTTATCAGACGTTAATCCAAGAAACACCTTTGGACAACTGTTCTGT GGCTCATTAGATCTTTTTGGAATCCTGTGTGTTGGCTTATACCGAATAATTGATGAAGAGGAGCTCAACCCAGAAAACAAAAGGTTTGTG ATCACCCGGCCAGCCAATGAGTTCAAGCTGCTGCCTTCAGATCTTGTGTTTTGTGCCATACCCTTCAGCACTGCTTGTTATAAAAGGAAT GAAGAGTTCTCATTGCAAAAGTCATATGAAATTGTAAATAAAGCATCACAGACAACAGAGACACATTCAGACACAAATTGTCCTCCCACC ATTGATTCAGTTACTGAGACATTGTATTCACCAGTCTATTCTTACCAGCCGAGAACTAACTCCCTCTCTTTTCCTAAGCAAATAGCATGG AATCAGAGTAGAACAAACAGTATTATATCATCTCAGATACCTTTAGGTGACAATGCAAAAGAAAATGAAAGGAAAACTTCAGATGAGGTT |
| * Fusion transcript sequences (Full-length transcript). |
| >In-frame_PLEKHA2_ENST00000420274_chr8_38814904_+_KCNU1_ENST00000399881_chr8_36663787_+_4261nt AATGCGAAACGTAATTAACCCGGAAAAAAGAGCCGAGGGACGGGAGAGAAGGAGGGGGCACTGGGGGAGACCAGAGCGAGGGGAGCGAGA GGCGCGGAGAGTTTGGCAGGCAGACCCAGAAATCCCTGGAGCGCGGCGGACCCGGCGGCCGGAGGGGCGACCCCGCCCGATGTAACGCGC CCCGCCCGAGCCCCGGCCCCTGCACGGGGGGGGTGATGTGAGCAGAGCCCAGGAATGCCTTATGTGGATCGGCAGAACCGAATCTGTGGG TTTCTGGACATCGAGGAGCATGAGAACAGCGGCAAGTTTCTGCGGAGGTACTTCATTCTGGACACCCAGGCTAACTGCCTCCTCTGGTAT ATGGACAACCCCCAGAATCTGGCAATGGGGGCAGGAGCTGTTGGAGCTTTGCAGCTGACCTACATCTCGAAGGTGAGCATAGCTACCCCA AAACAGAAACCAAAAACTCCATTTTGCTTTGTTATCAATGCCCTGTCTCAGAGATATTTCCTTCAAGCCAATGATCAGAAAGATATGAAG GACTGGGTTGAAGCCCTGAACCAAGCCAGCAAGATCACCGTTCCCAAAGGTGGGGGCCTACCCATGACCACTGAAGTTCTCAAGAGCTTA GCAGCTCCTCCAGCCCTGGAGAAGAAGCCACAGGTGGCCTACAAGACGGAGATCATTGGAGGGGTGGTGGTCCACACACCCATCAGCCAG AACGGTGGGGATGGGCAGGAAGGGAGTGAGCCCGGGTCCCACACCATCCTTCGAAGGTCTCAGAGTTACATCCCCACGTCAGGCTGCCGT GCTTCCACTGGGCCTCCCCTCATTAAGAGTGGTTACTGCGTGAAGCAAGGGAATGTGCGGAAGAGCTGGAAACGTCGCTTCTTTGCACTT GATGACTTTACCATCTGCTACTTCAAGTGTGAGCAGGACCGAGAACCACTGCGCACCATATTTCTTAAGGATGTTCTGAAGACCCATGAA TGTCTGGTCAAGTCTGGTGATCTCTTAATGAGGGACAACCTGTTTGAAATAATAACAAGCTCCAGGACCTTCTACGTACAGTTTATGGCA GCTGATGACAAGATCAAGTTCTGGCTGGAGATGAATTCAATCGTAGACATCTTTACCATCCCACCAACCTTTATTTCTTATTATTTGAAG AGCAATTGGCTAGGTTTAAGGTTCCTAAGAGCCTTGCGCCTGCTAGAACTCCCTCAAATCTTGCAAATTCTACGAGCCATCAAGACCAGT AACTCAGTGAAGTTTTCCAAACTGCTGTCAATAATTCTCAGTACCTGGTTCACAGCTGCGGGATTCATTCACCTGGTGGAAAATTCTGGT GATCCCTGGCTCAAAGGTAGAAATTCACAGAATATATCATATTTTGAGTCAATTTACCTGGTCATGGCAACAACGTCAACCGTTGGATTT GGAGATGTGGTAGCCAAGACATCCTTAGGACGGACCTTCATCATGTTCTTCACACTGGGGAGTTTGATATTATTTGCGAACTATATACCT GAAATGGTGGAACTGTTTGCTAACAAGAGGAAATACACCAGTTCCTATGAAGCACTCAAAGGAAAGAAGTTTATTGTGGTCTGTGGAAAC ATCACTGTGGACAGTGTGACCGCTTTCCTGAGGAATTTCCTCCGCGACAAGTCAGGAGAGATCAACACTGAAATTGTTTTCCTGGGAGAA ACCCCTCCTTCTTTGGAACTTGAAACCATATTTAAATGCTACTTGGCCTACACAACGTTCATTTCTGGATCTGCAATGAAGTGGGAGGAT CTGAGGCGAGTTGCGGTGGAATCTGCAGAGGCATGCCTGATTATAGCCAATCCTTTGTGCAGTGATTCCCATGCTGAAGATATTTCCAAC ATTATGAGGGTGCTCTCTATCAAGAACTATGATTCTACCACCAGAATCATCATACAGATACTGCAATCCCATAACAAGGTTTATCTGCCA AAGATTCCCAGCTGGAACTGGGACACCGGAGACAACATCATCTGCTTTGCTGAATTAAAACTTGGATTTATCGCCCAAGGCTGTTTGGTG CCAGGCTTGTGTACCTTCCTAACATCTCTATTTGTGGAGCAAAACAAAAAGGTTATGCCTAAACAGACCTGGAAGAAACACTTCTTGAAT AGCATGAAAAACAAAATTCTGACCCAACGTCTCTCTGATGACTTTGCTGGAATGAGCTTTCCTGAAGTTGCCCGGCTCTGCTTTCTGAAG ATGCACCTCCTGTTGATAGCCATCGAATACAAGTCCCTCTTTACGGATGGTTTCTGTGGTCTGATACTAAATCCACCTCCACAAGTGAGG ATACGTAAGAACACATTAGGGTTCTTTATTGCTGAAACTCCAAAGGACGTCAGAAGAGCCTTGTTTTACTGTTCAGTCTGTCATGATGAT GTGTTCATTCCTGAGCTAATTACAAACTGTGGCTGCAAAAGCAGAAGCCGGCAGCACATCACAGTGCCATCGGTAAAGAGAATGAAAAAA TGTCTGAAGGGAATCTCCTCTCGTATATCAGGGCAGGATTCTCCGCCAAGGGTATCTGCAAGCACTTCGAGCATATCAAACTTCACCACC AGGACTCTTCAACATGATGTAGAACAAGATTCTGACCAGCTTGATAGCAGTGGGATGTTTCACTGGTGCAAACCAACCTCTTTGGACAAG GTGACTCTGAAACGAACTGGCAAGTCAAAGTATAAGTTTCGGAACCATATTGTAGCATGTGTATTTGGAGATGCCCACTCAGCCCCGATG GGGCTTCGGAACTTTGTAATGCCCTTGAGAGCCAGCAACTATACCAGGAAGGAGCTGAAGGACATAGTGTTCATTGGGTCTCTGGACTAT CTACAGAGAGAATGGCGATTTCTCTGGAATTTTCCCCAGATATACATTCTGCCTGGATGTGCACTTTATTCTGGAGACCTCCATGCGGCC AACATAGAGCAATGCTCCATGTGTGCTGTCTTGTCCCCCCCACCCCAGCCATCAAGCAACCAGACTTTGGTAGACACAGAAGCCATCATG GCAACCCTCACCATCGGATCCTTGCAAATTGACTCCTCCTCTGACCCGTCACCCTCAGTGTCAGAGGAGACTCCAGGTTACACAAATGGA CATAATGAGAAATCAAACTGCCGAAAAGTCCCTATCCTTACTGAACTGAAAAATCCTTCCAACATTCACTTTATTGAACAGCTTGGTGGA CTGGAAGGGTCCCTCCAAGAAACAAATCTGCATCTCAGCACTGCCTTTTCTACGGGCACTGTTTTTTCCGGCAGCTTCTTGGATTCTCTG CTGGCCACGGCCTTCTACAATTATCATGTCCTGGAATTGCTTCAGATGCTGGTGACAGGAGGAGTAAGTTCTCAGCTGGAACAACATTTA GATAAGGATAAAGTCTATGGTGTGGCAGATAGCTGCACGTCGCTCTTGTCTGGAAGAAACCGGTGTAAGCTGGGGCTTCTGTCCTTACAC GAAACCATTTTATCAGACGTTAATCCAAGAAACACCTTTGGACAACTGTTCTGTGGCTCATTAGATCTTTTTGGAATCCTGTGTGTTGGC TTATACCGAATAATTGATGAAGAGGAGCTCAACCCAGAAAACAAAAGGTTTGTGATCACCCGGCCAGCCAATGAGTTCAAGCTGCTGCCT TCAGATCTTGTGTTTTGTGCCATACCCTTCAGCACTGCTTGTTATAAAAGGAATGAAGAGTTCTCATTGCAAAAGTCATATGAAATTGTA AATAAAGCATCACAGACAACAGAGACACATTCAGACACAAATTGTCCTCCCACCATTGATTCAGTTACTGAGACATTGTATTCACCAGTC TATTCTTACCAGCCGAGAACTAACTCCCTCTCTTTTCCTAAGCAAATAGCATGGAATCAGAGTAGAACAAACAGTATTATATCATCTCAG ATACCTTTAGGTGACAATGCAAAAGAAAATGAAAGGAAAACTTCAGATGAGGTTTATGATGAGGATCCCTTTGCATATTCAGAGCCACTA TAGACCTGCCCATATTCTTCACGTGCTCTTAACTTGCTGCTTACAAATCATCTCCTGAGATGCTAACTTTGAACAAAGAAAATAAGAATG GAAGCATGCCATTTTTCTGCCCATTGCTTAGTGGTTCATGAAGGCCACACTGTTTTGGGTGAGACAAAAGTCTAATGCCACTGGATCTTG |
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FusionGenePPI for PLEKHA2_KCNU1 |
| Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in . |
| Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160) |
| Hgene | Hgene's interactors | Tgene | Tgene's interactors |
| PLEKHA2 | PLEKHA1, MPDZ, CDH1, TRIM25 | KCNU1 |
| - Retained PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
| - Lost PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
| - Retained PPIs, but lost function due to frame-shift fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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RelatedDrugs for PLEKHA2_KCNU1 |
| Drugs targeting genes involved in this fusion gene. (DrugBank Version 5.1.0 2018-04-02) |
| Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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RelatedDiseases for PLEKHA2_KCNU1 |
| Diseases associated with fusion partners. (DisGeNet 4.0) |
| Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
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