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Fusion gene ID: 27570 |
FusionGeneSummary for PLEKHA2_IDO2 |
 Fusion gene summary |
| Fusion gene information | Fusion gene name: PLEKHA2_IDO2 | Fusion gene ID: 27570 | Hgene | Tgene | Gene symbol | PLEKHA2 | IDO2 | Gene ID | 59339 | 169355 |
| Gene name | pleckstrin homology domain containing A2 | indoleamine 2,3-dioxygenase 2 | |
| Synonyms | TAPP2 | INDOL1 | |
| Cytomap | 8p11.22 | 8p11.21 | |
| Type of gene | protein-coding | protein-coding | |
| Description | pleckstrin homology domain-containing family A member 2PH domain-containing family A member 2TAPP-2pleckstrin homology domain containing, family A (phosphoinositide binding specific) member 2tandem PH Domain containing protein-2tandem PH domain-conta | indoleamine 2,3-dioxygenase 2IDO-2indoleamine 2,3-dioxygenase-like 1 proteinindoleamine 2,3-dioxygenase-like protein 1indoleamine-pyrrole 2,3 dioxygenase-like 1indoleamine-pyrrole 2,3-dioxygenase-like protein 1 | |
| Modification date | 20180523 | 20180519 | |
| UniProtAcc | Q9HB19 | Q6ZQW0 | |
| Ensembl transtripts involved in fusion gene | ENST00000521746, ENST00000420274, ENST00000388745, | ENST00000343295, ENST00000502986, ENST00000389060, | |
| Fusion gene scores | * DoF score | 7 X 6 X 5=210 | 5 X 5 X 5=125 |
| # samples | 8 | 5 | |
| ** MAII score | log2(8/210*10)=-1.39231742277876 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | log2(5/125*10)=-1.32192809488736 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | |
| Context | PubMed: PLEKHA2 [Title/Abstract] AND IDO2 [Title/Abstract] AND fusion [Title/Abstract] | ||
| Functional or gene categories assigned by FusionGDB annotation | |||
| * DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
| Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Partner | Gene | GO ID | GO term | PubMed ID |
| Tgene | IDO2 | GO:0019441 | tryptophan catabolic process to kynurenine | 17671174 |
| Fusion gene information from three resources (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| TCGA | RV | PAAD | TCGA-LB-A9Q5-01A | PLEKHA2 | chr8 | 38793568 | + | IDO2 | chr8 | 39847240 | + |
| * LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
| Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| 5CDS-3UTR | ENST00000521746 | ENST00000343295 | PLEKHA2 | chr8 | 38793568 | + | IDO2 | chr8 | 39847240 | + |
| 5CDS-3UTR | ENST00000521746 | ENST00000502986 | PLEKHA2 | chr8 | 38793568 | + | IDO2 | chr8 | 39847240 | + |
| 5CDS-3UTR | ENST00000521746 | ENST00000389060 | PLEKHA2 | chr8 | 38793568 | + | IDO2 | chr8 | 39847240 | + |
| 5CDS-3UTR | ENST00000420274 | ENST00000343295 | PLEKHA2 | chr8 | 38793568 | + | IDO2 | chr8 | 39847240 | + |
| 5CDS-3UTR | ENST00000420274 | ENST00000502986 | PLEKHA2 | chr8 | 38793568 | + | IDO2 | chr8 | 39847240 | + |
| 5CDS-3UTR | ENST00000420274 | ENST00000389060 | PLEKHA2 | chr8 | 38793568 | + | IDO2 | chr8 | 39847240 | + |
| 3UTR-3UTR | ENST00000388745 | ENST00000343295 | PLEKHA2 | chr8 | 38793568 | + | IDO2 | chr8 | 39847240 | + |
| 3UTR-3UTR | ENST00000388745 | ENST00000502986 | PLEKHA2 | chr8 | 38793568 | + | IDO2 | chr8 | 39847240 | + |
| 3UTR-3UTR | ENST00000388745 | ENST00000389060 | PLEKHA2 | chr8 | 38793568 | + | IDO2 | chr8 | 39847240 | + |
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FusionProtFeatures for PLEKHA2_IDO2 |
| Main function of each fusion partner protein. (from UniProt) |
| Hgene | Tgene |
| PLEKHA2 | IDO2 |
| Binds specifically to phosphatidylinositol 3,4-diphosphate (PtdIns3,4P2), but not to other phosphoinositides. Mayrecruit other proteins to the plasma membrane (By similarity).{ECO:0000250}. | Catalyzes the first and rate limiting step of thecatabolism of the essential amino acid tryptophan along thekynurenine pathway (PubMed:17671174). Involved in immuneregulation. May not play a significant role in tryptophan-relatedtumoral resistance (PubMed:25691885).{ECO:0000269|PubMed:17671174, ECO:0000303|PubMed:25691885}. |
| Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at . * Minus value of BPloci means that the break pointn is located before the CDS. |
| - In-frame and retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
| - In-frame and not-retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
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FusionGeneSequence for PLEKHA2_IDO2 |
| For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. (nt: nucleotides, aa: amino acids) |
| * Fusion amino acid sequences. |
| * Fusion transcript sequences (only coding sequence (CDS) region). |
| * Fusion transcript sequences (Full-length transcript). |
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FusionGenePPI for PLEKHA2_IDO2 |
| Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in . |
| Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160) |
| Hgene | Hgene's interactors | Tgene | Tgene's interactors |
| PLEKHA2 | PLEKHA1, MPDZ, CDH1, TRIM25 | IDO2 | DPP8, NRN1, ATF1, ERICH5, ULBP2, EME1, SMARCA1, KLF12, FAM171A2 |
| - Retained PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
| - Lost PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
| - Retained PPIs, but lost function due to frame-shift fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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RelatedDrugs for PLEKHA2_IDO2 |
| Drugs targeting genes involved in this fusion gene. (DrugBank Version 5.1.0 2018-04-02) |
| Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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RelatedDiseases for PLEKHA2_IDO2 |
| Diseases associated with fusion partners. (DisGeNet 4.0) |
| Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
Copyright 2018-Present -The University of Texas Health Science Center at Houston (UTHealth)
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