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Fusion gene ID: 27511 |
FusionGeneSummary for PLCG1_TAF4 |
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Fusion gene information | Fusion gene name: PLCG1_TAF4 | Fusion gene ID: 27511 | Hgene | Tgene | Gene symbol | PLCG1 | TAF4 | Gene ID | 5335 | 6874 |
Gene name | phospholipase C gamma 1 | TATA-box binding protein associated factor 4 | |
Synonyms | NCKAP3|PLC-II|PLC1|PLC148|PLCgamma1 | TAF2C|TAF2C1|TAF4A|TAFII130|TAFII135 | |
Cytomap | 20q12 | 20q13.33 | |
Type of gene | protein-coding | protein-coding | |
Description | 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-11-phosphatidyl-D-myo-inositol-4,5-bisphosphatePLC-148PLC-gamma-1inositoltrisphosphohydrolasemonophosphatidylinositol phosphodiesterasephosphatidylinositol phospholipase Cphosphoinosit | transcription initiation factor TFIID subunit 4RNA polymerase II TBP-associated factor subunit CTAF(II)130TAF(II)135TAF4 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 135kDaTAF4A RNA polymerase II, TATA box binding protein (TBP | |
Modification date | 20180522 | 20180523 | |
UniProtAcc | P19174 | O00268 | |
Ensembl transtripts involved in fusion gene | ENST00000244007, ENST00000373272, ENST00000373271, ENST00000608689, | ENST00000252996, ENST00000609045, | |
Fusion gene scores | * DoF score | 4 X 3 X 3=36 | 5 X 6 X 2=60 |
# samples | 4 | 12 | |
** MAII score | log2(4/36*10)=0.15200309344505 effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs). DoF>8 and MAII>0 | log2(12/60*10)=1 effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs). DoF>8 and MAII>0 | |
Context | PubMed: PLCG1 [Title/Abstract] AND TAF4 [Title/Abstract] AND fusion [Title/Abstract] | ||
Functional or gene categories assigned by FusionGDB annotation |
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
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Partner | Gene | GO ID | GO term | PubMed ID |
Hgene | PLCG1 | GO:0043536 | positive regulation of blood vessel endothelial cell migration | 20011604 |
Hgene | PLCG1 | GO:0045766 | positive regulation of angiogenesis | 20011604 |
Hgene | PLCG1 | GO:0071364 | cellular response to epidermal growth factor stimulus | 17229814 |
Tgene | TAF4 | GO:0006352 | DNA-templated transcription, initiation | 9603525 |
Tgene | TAF4 | GO:0006367 | transcription initiation from RNA polymerase II promoter | 9603525 |
Tgene | TAF4 | GO:0045893 | positive regulation of transcription, DNA-templated | 12771217 |
![]() (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
TCGA | RV | BRCA | TCGA-EW-A2FW-01A | PLCG1 | chr20 | 39766498 | + | TAF4 | chr20 | 60584230 | - |
* LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
![]() * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
Frame-shift | ENST00000244007 | ENST00000252996 | PLCG1 | chr20 | 39766498 | + | TAF4 | chr20 | 60584230 | - |
5CDS-intron | ENST00000244007 | ENST00000609045 | PLCG1 | chr20 | 39766498 | + | TAF4 | chr20 | 60584230 | - |
Frame-shift | ENST00000373272 | ENST00000252996 | PLCG1 | chr20 | 39766498 | + | TAF4 | chr20 | 60584230 | - |
5CDS-intron | ENST00000373272 | ENST00000609045 | PLCG1 | chr20 | 39766498 | + | TAF4 | chr20 | 60584230 | - |
Frame-shift | ENST00000373271 | ENST00000252996 | PLCG1 | chr20 | 39766498 | + | TAF4 | chr20 | 60584230 | - |
5CDS-intron | ENST00000373271 | ENST00000609045 | PLCG1 | chr20 | 39766498 | + | TAF4 | chr20 | 60584230 | - |
intron-3CDS | ENST00000608689 | ENST00000252996 | PLCG1 | chr20 | 39766498 | + | TAF4 | chr20 | 60584230 | - |
intron-intron | ENST00000608689 | ENST00000609045 | PLCG1 | chr20 | 39766498 | + | TAF4 | chr20 | 60584230 | - |
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FusionProtFeatures for PLCG1_TAF4 |
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Hgene | Tgene |
PLCG1 | TAF4 |
Mediates the production of the second messengermolecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate(IP3). Plays an important role in the regulation of intracellularsignaling cascades. Becomes activated in response to ligand-mediated activation of receptor-type tyrosine kinases, such asPDGFRA, PDGFRB, FGFR1, FGFR2, FGFR3 and FGFR4. Plays a role inactin reorganization and cell migration.{ECO:0000269|PubMed:17229814}. | Part of the TFIID complex, a multimeric protein complexthat plays a central role in mediating promoter responses tovarious activators and repressors. Potentiates transcriptionalactivation by the AF-2S of the retinoic acid, vitamin D3 andthyroid hormone. |
![]() * Minus value of BPloci means that the break pointn is located before the CDS. |
- In-frame and retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
- In-frame and not-retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
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FusionGeneSequence for PLCG1_TAF4 |
![]() (nt: nucleotides, aa: amino acids) |
* Fusion amino acid sequences. |
* Fusion transcript sequences (only coding sequence (CDS) region). |
* Fusion transcript sequences (Full-length transcript). |
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FusionGenePPI for PLCG1_TAF4 |
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Hgene | Hgene's interactors | Tgene | Tgene's interactors |
PLCG1 | EEF1A1, GIT1, SELE, DGKZ, PLD2, SRC, WAS, VAV1, KHDRBS1, GAB1, LCP2, SH3BP2, DOK1, KIT, GRB2, SHC1, NTRK1, RASA1, SYK, SHB, LAT, RHOA, PKN2, ALK, PDGFA, PDGFRB, PAK1, PTK2, PRKD1, ITK, SYNCRIP, FGFR1, ZAP70, PDGFRA, ARHGAP32, NTRK2, NTRK3, LAT2, SH2B3, RET, TRPM7, TNK1, ERBB2, FLT1, KDR, CBL, EGFR, GNB2L1, IRS2, PTPRJ, PICALM, SOS1, PECAM1, CD22, GHR, SOS2, TUB, MST1R, ABL1, GAB2, GSN, BAG3, LTK, PARK2, EPHB2, PLXNB1, PLXNB2, ARHGEF2, CAMK2A, EPOR, BLNK, IBTK, PML, NCAM1, NPM1, SPRY1, NTMT1, INSR, ERBB3, JAK1, JAK2, EHD4, GTF3C4, LIMD1, AASDHPPT, DPP7, RIC8A, RPL38, SARNP, UBR7, WDR61, PYGB, NXF1, AKT1, CAV1, MVB12B, GAS2L1, SNX11, TEKT2, LDLRAD4, CTPS1, MCMBP, NPEPL1, PFKP, RNF40, STRAP, UCHL5, SKIV2L, TIPRL, UNC45A, FGFR2, PLCG2, PTPN6, DOK2, NCKIPSD, CACNB3, KHDRBS2, RAB11A, CCDC120, TTC9B, KCNJ5, LZTS2, ZNF785, HNRNPK | TAF4 | TBP, CBX5, TAF1, GTF2A2, TAF4, TAF12, TAF8, TAF5, KAT2A, SUPT3H, TAF10, CREM, SP1, TAF9, TAF13, TBPL1, GTF2A1, ATF7, CREB1, TCF12, ELAVL1, TAF6, TAF7, TRRAP, TAF3, TAF9B, TAF1L, AHR, HTT, JUN, GTF2F2, HIST3H3, MED26, FBXO6, SOX6, EGFR, NUP50, ANAPC1, ANAPC7, CDC16, NAP1L4, ANAPC13, CDC23, CDC27, NCL, SF3B3, EWSR1, HIST1H3E, KIFAP3, TAF7L, TAF11 |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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RelatedDrugs for PLCG1_TAF4 |
![]() (DrugBank Version 5.1.0 2018-04-02) |
Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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RelatedDiseases for PLCG1_TAF4 |
![]() (DisGeNet 4.0) |
Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
Hgene | PLCG1 | C0005586 | Bipolar Disorder | 1 | PSYGENET |
Hgene | PLCG1 | C0018923 | Hemangiosarcoma | 1 | CTD_human |
Hgene | PLCG1 | C0023493 | Adult T-Cell Lymphoma/Leukemia | 1 | CTD_human |
Hgene | PLCG1 | C0036920 | Sezary Syndrome | 1 | CTD_human |
Hgene | PLCG1 | C0079773 | Lymphoma, T-Cell, Cutaneous | 1 | CTD_human |