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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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Fusion gene ID: 27504

FusionGeneSummary for PLCD4_VIL1

check button Fusion gene summary
Fusion gene informationFusion gene name: PLCD4_VIL1
Fusion gene ID: 27504
HgeneTgene
Gene symbol

PLCD4

VIL1

Gene ID

84812

7429

Gene namephospholipase C delta 4villin 1
Synonyms-D2S1471|VIL
Cytomap

2q35

2q35

Type of geneprotein-codingprotein-coding
Description1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase delta-4PLC delta4phosphoinositide phospholipase C-delta-4villin-1
Modification date2018051920180520
UniProtAcc

Q9BRC7

P09327

Ensembl transtripts involved in fusion geneENST00000450993, ENST00000417849, 
ENST00000432688, 
ENST00000248444, 
ENST00000392114, ENST00000440053, 
Fusion gene scores* DoF score1 X 1 X 1=12 X 2 X 2=8
# samples 14
** MAII scorelog2(1/1*10)=3.32192809488736log2(4/8*10)=2.32192809488736
Context

PubMed: PLCD4 [Title/Abstract] AND VIL1 [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotationTumor suppressor gene involved fusion gene, in-frame but not retained their domain.
Tumor suppressor gene involved fusion gene, retained protein feature but frameshift.
DDR (DNA damage repair) gene involved fusion gene, in-frame but not retained their domain.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
TgeneVIL1

GO:0007173

epidermal growth factor receptor signaling pathway

17229814

TgeneVIL1

GO:0008360

regulation of cell shape

16921170

TgeneVIL1

GO:0009617

response to bacterium

17182858

TgeneVIL1

GO:0010634

positive regulation of epithelial cell migration

17229814

TgeneVIL1

GO:0030041

actin filament polymerization

11500485

TgeneVIL1

GO:0030042

actin filament depolymerization

11500485

TgeneVIL1

GO:0030335

positive regulation of cell migration

16921170

TgeneVIL1

GO:0032233

positive regulation of actin filament bundle assembly

19808673

TgeneVIL1

GO:0051014

actin filament severing

16921170|17182858|19808673

TgeneVIL1

GO:0051125

regulation of actin nucleation

16921170|17182858|19808673

TgeneVIL1

GO:0051693

actin filament capping

16921170|17182858|19808673

TgeneVIL1

GO:0060327

cytoplasmic actin-based contraction involved in cell motility

15342783

TgeneVIL1

GO:0071364

cellular response to epidermal growth factor stimulus

17229814


check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
TCGARVBRCATCGA-E2-A1LE-01APLCD4chr2

219487601

+VIL1chr2

219313946

+
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
In-frameENST00000450993ENST00000248444PLCD4chr2

219487601

+VIL1chr2

219313946

+
In-frameENST00000450993ENST00000392114PLCD4chr2

219487601

+VIL1chr2

219313946

+
5CDS-intronENST00000450993ENST00000440053PLCD4chr2

219487601

+VIL1chr2

219313946

+
In-frameENST00000417849ENST00000248444PLCD4chr2

219487601

+VIL1chr2

219313946

+
In-frameENST00000417849ENST00000392114PLCD4chr2

219487601

+VIL1chr2

219313946

+
5CDS-intronENST00000417849ENST00000440053PLCD4chr2

219487601

+VIL1chr2

219313946

+
In-frameENST00000432688ENST00000248444PLCD4chr2

219487601

+VIL1chr2

219313946

+
In-frameENST00000432688ENST00000392114PLCD4chr2

219487601

+VIL1chr2

219313946

+
5CDS-intronENST00000432688ENST00000440053PLCD4chr2

219487601

+VIL1chr2

219313946

+

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FusionProtFeatures for PLCD4_VIL1


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
PLCD4

Q9BRC7

VIL1

P09327

Hydrolyzes the phosphatidylinositol 4,5-bisphosphate(PIP2) to generate 2 second messenger molecules diacylglycerol(DAG) and inositol 1,4,5-trisphosphate (IP3). DAG mediates theactivation of protein kinase C (PKC), while IP3 releases Ca(2+)from intracellular stores. Required for acrosome reaction in spermduring fertilization, probably by acting as an important enzymefor intracellular Ca(2+) mobilization in the zona pellucida-induced acrosome reaction. May play a role in cell growth.Modulates the liver regeneration in cooperation with nuclear PKC.Overexpression up-regulates the Erk signaling pathway andproliferation. {ECO:0000269|PubMed:15140260}. Epithelial cell-specific Ca(2+)-regulated actin-modifying protein that modulates the reorganization of microvillaractin filaments. Plays a role in the actin nucleation, actinfilament bundle assembly, actin filament capping and severing.Binds phosphatidylinositol 4,5-bisphosphate (PIP2) andlysophosphatidic acid (LPA); binds LPA with higher affinity thanPIP2. Binding to LPA increases its phosphorylation by SRC andinhibits all actin-modifying activities. Binding to PIP2 inhibitsactin-capping and -severing activities but enhances actin-bundlingactivity. Regulates the intestinal epithelial cell morphology,cell invasion, cell migration and apoptosis. Protects againstapoptosis induced by dextran sodium sulfate (DSS) in thegastrointestinal epithelium. Appears to regulate cell death bymaintaining mitochondrial integrity. Enhances hepatocyte growthfactor (HGF)-induced epithelial cell motility, chemotaxis andwound repair. Upon S.flexneri cell infection, its actin-severingactivity enhances actin-based motility of the bacteria and plays arole during the dissemination. {ECO:0000269|PubMed:11500485,ECO:0000269|PubMed:14594952, ECO:0000269|PubMed:15084600,ECO:0000269|PubMed:15272027, ECO:0000269|PubMed:15342783,ECO:0000269|PubMed:16921170, ECO:0000269|PubMed:17182858,ECO:0000269|PubMed:17229814, ECO:0000269|PubMed:17606613,ECO:0000269|PubMed:18054784, ECO:0000269|PubMed:18198174,ECO:0000269|PubMed:19808673, ECO:0000269|PubMed:3087992}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
>
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgenePLCD4chr2:219487601chr2:219313946ENST00000417849+617147_158257800Calcium binding1
HgenePLCD4chr2:219487601chr2:219313946ENST00000417849+617183_194257800Calcium binding2
HgenePLCD4chr2:219487601chr2:219313946ENST00000450993+616147_158257763Calcium binding1
HgenePLCD4chr2:219487601chr2:219313946ENST00000450993+616183_194257763Calcium binding2
HgenePLCD4chr2:219487601chr2:219313946ENST00000417849+617134_169257800DomainEF-hand 1
HgenePLCD4chr2:219487601chr2:219313946ENST00000417849+61716_124257800DomainPH
HgenePLCD4chr2:219487601chr2:219313946ENST00000417849+617170_205257800DomainEF-hand 2
HgenePLCD4chr2:219487601chr2:219313946ENST00000417849+617203_237257800DomainEF-hand 3
HgenePLCD4chr2:219487601chr2:219313946ENST00000450993+616134_169257763DomainEF-hand 1
HgenePLCD4chr2:219487601chr2:219313946ENST00000450993+61616_124257763DomainPH
HgenePLCD4chr2:219487601chr2:219313946ENST00000450993+616170_205257763DomainEF-hand 2
HgenePLCD4chr2:219487601chr2:219313946ENST00000450993+616203_237257763DomainEF-hand 3
HgenePLCD4chr2:219487601chr2:219313946ENST00000417849+61726_53257800RegionSubstrate binding
HgenePLCD4chr2:219487601chr2:219313946ENST00000450993+61626_53257763RegionSubstrate binding
TgeneVIL1chr2:219487601chr2:219313946ENST00000248444+1820816_824790828RegionNote=LPA/PIP2-binding site 3

- In-frame and not-retained protein feature among the 13 regional features.
>>>>>>>>>>>>
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgenePLCD4chr2:219487601chr2:219313946ENST00000417849+617440_473257800Compositional biasNote=Glu-rich
HgenePLCD4chr2:219487601chr2:219313946ENST00000417849+617479_486257800Compositional biasNote=Poly-Lys
HgenePLCD4chr2:219487601chr2:219313946ENST00000450993+616440_473257763Compositional biasNote=Glu-rich
HgenePLCD4chr2:219487601chr2:219313946ENST00000450993+616479_486257763Compositional biasNote=Poly-Lys
HgenePLCD4chr2:219487601chr2:219313946ENST00000417849+617290_435257800DomainPI-PLC X-box
HgenePLCD4chr2:219487601chr2:219313946ENST00000417849+617493_609257800DomainPI-PLC Y-box
HgenePLCD4chr2:219487601chr2:219313946ENST00000417849+617614_719257800DomainC2
HgenePLCD4chr2:219487601chr2:219313946ENST00000450993+616290_435257763DomainPI-PLC X-box
HgenePLCD4chr2:219487601chr2:219313946ENST00000450993+616493_609257763DomainPI-PLC Y-box
HgenePLCD4chr2:219487601chr2:219313946ENST00000450993+616614_719257763DomainC2
HgenePLCD4chr2:219487601chr2:219313946ENST00000417849+617731_734257800MotifNote=PDZ-binding
HgenePLCD4chr2:219487601chr2:219313946ENST00000450993+616731_734257763MotifNote=PDZ-binding
TgeneVIL1chr2:219487601chr2:219313946ENST00000248444+1820761_827790828DomainHP
TgeneVIL1chr2:219487601chr2:219313946ENST00000248444+1820112_119790828RegionNote=LPA/PIP2-binding site 1
TgeneVIL1chr2:219487601chr2:219313946ENST00000248444+1820138_146790828RegionNote=LPA/PIP2-binding site 2
TgeneVIL1chr2:219487601chr2:219313946ENST00000248444+18202_126790828RegionNote=Necessary for homodimerization
TgeneVIL1chr2:219487601chr2:219313946ENST00000248444+18202_734790828RegionNote=Core
TgeneVIL1chr2:219487601chr2:219313946ENST00000248444+1820735_827790828RegionNote=Headpiece
TgeneVIL1chr2:219487601chr2:219313946ENST00000248444+1820148_188790828RepeatNote=Gelsolin-like 2
TgeneVIL1chr2:219487601chr2:219313946ENST00000248444+1820265_309790828RepeatNote=Gelsolin-like 3
TgeneVIL1chr2:219487601chr2:219313946ENST00000248444+182027_76790828RepeatNote=Gelsolin-like 1
TgeneVIL1chr2:219487601chr2:219313946ENST00000248444+1820407_457790828RepeatNote=Gelsolin-like 4
TgeneVIL1chr2:219487601chr2:219313946ENST00000248444+1820528_568790828RepeatNote=Gelsolin-like 5
TgeneVIL1chr2:219487601chr2:219313946ENST00000248444+1820631_672790828RepeatNote=Gelsolin-like 6


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FusionGeneSequence for PLCD4_VIL1


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.
>In-frame_PLCD4_ENST00000450993_chr2_219487601_+_VIL1_ENST00000248444_chr2_219313946_+_295aa
MASLLQDQLTTDQDLLLMQEGMPMRKVRSKSWKKLRYFRLQNDGMTVWHARQARGSAKPSFSISDVETIRNGHDSELLRSLAEELPLEQG
FTIVFHGRRSNLDLMANSVEEAQIWMRGLQLLVDLVTSMDHQERLDQWLSDWFQRGDKNQDGKMSFQEVQRLLHLMNVEMDQEYAFSLFQ
AADTSQSGTLEGEEFVQFYKALTKRAEVQELFESFSADGQKLTLLEFLDFLQEEQKERDCTSELALELIDRYEPSDSGTPVHXRFHSGLW

>In-frame_PLCD4_ENST00000450993_chr2_219487601_+_VIL1_ENST00000392114_chr2_219313946_+_295aa
MASLLQDQLTTDQDLLLMQEGMPMRKVRSKSWKKLRYFRLQNDGMTVWHARQARGSAKPSFSISDVETIRNGHDSELLRSLAEELPLEQG
FTIVFHGRRSNLDLMANSVEEAQIWMRGLQLLVDLVTSMDHQERLDQWLSDWFQRGDKNQDGKMSFQEVQRLLHLMNVEMDQEYAFSLFQ
AADTSQSGTLEGEEFVQFYKALTKRAEVQELFESFSADGQKLTLLEFLDFLQEEQKERDCTSELALELIDRYEPSDSGTPVHXRFHSGLW

>In-frame_PLCD4_ENST00000417849_chr2_219487601_+_VIL1_ENST00000248444_chr2_219313946_+_295aa
MASLLQDQLTTDQDLLLMQEGMPMRKVRSKSWKKLRYFRLQNDGMTVWHARQARGSAKPSFSISDVETIRNGHDSELLRSLAEELPLEQG
FTIVFHGRRSNLDLMANSVEEAQIWMRGLQLLVDLVTSMDHQERLDQWLSDWFQRGDKNQDGKMSFQEVQRLLHLMNVEMDQEYAFSLFQ
AADTSQSGTLEGEEFVQFYKALTKRAEVQELFESFSADGQKLTLLEFLDFLQEEQKERDCTSELALELIDRYEPSDSGTPVHXRFHSGLW

>In-frame_PLCD4_ENST00000417849_chr2_219487601_+_VIL1_ENST00000392114_chr2_219313946_+_295aa
MASLLQDQLTTDQDLLLMQEGMPMRKVRSKSWKKLRYFRLQNDGMTVWHARQARGSAKPSFSISDVETIRNGHDSELLRSLAEELPLEQG
FTIVFHGRRSNLDLMANSVEEAQIWMRGLQLLVDLVTSMDHQERLDQWLSDWFQRGDKNQDGKMSFQEVQRLLHLMNVEMDQEYAFSLFQ
AADTSQSGTLEGEEFVQFYKALTKRAEVQELFESFSADGQKLTLLEFLDFLQEEQKERDCTSELALELIDRYEPSDSGTPVHXRFHSGLW

>In-frame_PLCD4_ENST00000432688_chr2_219487601_+_VIL1_ENST00000248444_chr2_219313946_+_295aa
MASLLQDQLTTDQDLLLMQEGMPMRKVRSKSWKKLRYFRLQNDGMTVWHARQARGSAKPSFSISDVETIRNGHDSELLRSLAEELPLEQG
FTIVFHGRRSNLDLMANSVEEAQIWMRGLQLLVDLVTSMDHQERLDQWLSDWFQRGDKNQDGKMSFQEVQRLLHLMNVEMDQEYAFSLFQ
AADTSQSGTLEGEEFVQFYKALTKRAEVQELFESFSADGQKLTLLEFLDFLQEEQKERDCTSELALELIDRYEPSDSGTPVHXRFHSGLW

>In-frame_PLCD4_ENST00000432688_chr2_219487601_+_VIL1_ENST00000392114_chr2_219313946_+_295aa
MASLLQDQLTTDQDLLLMQEGMPMRKVRSKSWKKLRYFRLQNDGMTVWHARQARGSAKPSFSISDVETIRNGHDSELLRSLAEELPLEQG
FTIVFHGRRSNLDLMANSVEEAQIWMRGLQLLVDLVTSMDHQERLDQWLSDWFQRGDKNQDGKMSFQEVQRLLHLMNVEMDQEYAFSLFQ
AADTSQSGTLEGEEFVQFYKALTKRAEVQELFESFSADGQKLTLLEFLDFLQEEQKERDCTSELALELIDRYEPSDSGTPVHXRFHSGLW


* Fusion transcript sequences (only coding sequence (CDS) region).
>In-frame_PLCD4_ENST00000450993_chr2_219487601_+_VIL1_ENST00000248444_chr2_219313946_+_886nt
ATGGCGTCCCTGCTGCAAGACCAGCTGACCACTGATCAGGACTTGCTGCTGATGCAGGAAGGCATGCCGATGCGCAAGGTGAGGTCCAAA
AGCTGGAAGAAGCTAAGATACTTCAGACTTCAGAATGACGGCATGACAGTCTGGCATGCACGGCAGGCCAGGGGCAGTGCCAAGCCCAGC
TTCTCAATCTCTGATGTGGAGACAATACGTAATGGCCATGATTCCGAGTTGCTGCGTAGCCTGGCAGAGGAGCTCCCCCTGGAGCAGGGC
TTCACCATTGTCTTCCATGGCCGCCGCTCCAACCTGGACCTGATGGCCAACAGTGTTGAGGAGGCCCAGATATGGATGCGAGGGCTCCAG
CTGTTGGTGGATCTTGTCACCAGCATGGACCATCAGGAGCGCCTGGACCAATGGCTGAGCGATTGGTTTCAACGTGGAGACAAAAATCAG
GATGGTAAGATGAGTTTCCAAGAAGTTCAGCGGTTATTGCACCTAATGAATGTGGAAATGGACCAAGAATATGCCTTCAGTCTTTTTCAG
GCAGCAGACACGTCCCAGTCTGGAACCCTGGAAGGAGAAGAATTCGTACAGTTCTATAAGGCATTGACTAAACGTGCTGAGGTGCAGGAA
CTGTTTGAAAGTTTTTCAGCTGATGGGCAGAAGCTGACTCTGCTGGAATTTTTGGATTTCCTCCAAGAGGAGCAGAAGGAGAGAGACTGC
ACCTCTGAGCTTGCTCTGGAACTCATTGACCGCTATGAACCTTCAGACAGTGGAACACCTGTCCATTGAAGATTTCACTCAGGCCTTTGG

>In-frame_PLCD4_ENST00000450993_chr2_219487601_+_VIL1_ENST00000392114_chr2_219313946_+_886nt
ATGGCGTCCCTGCTGCAAGACCAGCTGACCACTGATCAGGACTTGCTGCTGATGCAGGAAGGCATGCCGATGCGCAAGGTGAGGTCCAAA
AGCTGGAAGAAGCTAAGATACTTCAGACTTCAGAATGACGGCATGACAGTCTGGCATGCACGGCAGGCCAGGGGCAGTGCCAAGCCCAGC
TTCTCAATCTCTGATGTGGAGACAATACGTAATGGCCATGATTCCGAGTTGCTGCGTAGCCTGGCAGAGGAGCTCCCCCTGGAGCAGGGC
TTCACCATTGTCTTCCATGGCCGCCGCTCCAACCTGGACCTGATGGCCAACAGTGTTGAGGAGGCCCAGATATGGATGCGAGGGCTCCAG
CTGTTGGTGGATCTTGTCACCAGCATGGACCATCAGGAGCGCCTGGACCAATGGCTGAGCGATTGGTTTCAACGTGGAGACAAAAATCAG
GATGGTAAGATGAGTTTCCAAGAAGTTCAGCGGTTATTGCACCTAATGAATGTGGAAATGGACCAAGAATATGCCTTCAGTCTTTTTCAG
GCAGCAGACACGTCCCAGTCTGGAACCCTGGAAGGAGAAGAATTCGTACAGTTCTATAAGGCATTGACTAAACGTGCTGAGGTGCAGGAA
CTGTTTGAAAGTTTTTCAGCTGATGGGCAGAAGCTGACTCTGCTGGAATTTTTGGATTTCCTCCAAGAGGAGCAGAAGGAGAGAGACTGC
ACCTCTGAGCTTGCTCTGGAACTCATTGACCGCTATGAACCTTCAGACAGTGGAACACCTGTCCATTGAAGATTTCACTCAGGCCTTTGG

>In-frame_PLCD4_ENST00000417849_chr2_219487601_+_VIL1_ENST00000248444_chr2_219313946_+_886nt
ATGGCGTCCCTGCTGCAAGACCAGCTGACCACTGATCAGGACTTGCTGCTGATGCAGGAAGGCATGCCGATGCGCAAGGTGAGGTCCAAA
AGCTGGAAGAAGCTAAGATACTTCAGACTTCAGAATGACGGCATGACAGTCTGGCATGCACGGCAGGCCAGGGGCAGTGCCAAGCCCAGC
TTCTCAATCTCTGATGTGGAGACAATACGTAATGGCCATGATTCCGAGTTGCTGCGTAGCCTGGCAGAGGAGCTCCCCCTGGAGCAGGGC
TTCACCATTGTCTTCCATGGCCGCCGCTCCAACCTGGACCTGATGGCCAACAGTGTTGAGGAGGCCCAGATATGGATGCGAGGGCTCCAG
CTGTTGGTGGATCTTGTCACCAGCATGGACCATCAGGAGCGCCTGGACCAATGGCTGAGCGATTGGTTTCAACGTGGAGACAAAAATCAG
GATGGTAAGATGAGTTTCCAAGAAGTTCAGCGGTTATTGCACCTAATGAATGTGGAAATGGACCAAGAATATGCCTTCAGTCTTTTTCAG
GCAGCAGACACGTCCCAGTCTGGAACCCTGGAAGGAGAAGAATTCGTACAGTTCTATAAGGCATTGACTAAACGTGCTGAGGTGCAGGAA
CTGTTTGAAAGTTTTTCAGCTGATGGGCAGAAGCTGACTCTGCTGGAATTTTTGGATTTCCTCCAAGAGGAGCAGAAGGAGAGAGACTGC
ACCTCTGAGCTTGCTCTGGAACTCATTGACCGCTATGAACCTTCAGACAGTGGAACACCTGTCCATTGAAGATTTCACTCAGGCCTTTGG

>In-frame_PLCD4_ENST00000417849_chr2_219487601_+_VIL1_ENST00000392114_chr2_219313946_+_886nt
ATGGCGTCCCTGCTGCAAGACCAGCTGACCACTGATCAGGACTTGCTGCTGATGCAGGAAGGCATGCCGATGCGCAAGGTGAGGTCCAAA
AGCTGGAAGAAGCTAAGATACTTCAGACTTCAGAATGACGGCATGACAGTCTGGCATGCACGGCAGGCCAGGGGCAGTGCCAAGCCCAGC
TTCTCAATCTCTGATGTGGAGACAATACGTAATGGCCATGATTCCGAGTTGCTGCGTAGCCTGGCAGAGGAGCTCCCCCTGGAGCAGGGC
TTCACCATTGTCTTCCATGGCCGCCGCTCCAACCTGGACCTGATGGCCAACAGTGTTGAGGAGGCCCAGATATGGATGCGAGGGCTCCAG
CTGTTGGTGGATCTTGTCACCAGCATGGACCATCAGGAGCGCCTGGACCAATGGCTGAGCGATTGGTTTCAACGTGGAGACAAAAATCAG
GATGGTAAGATGAGTTTCCAAGAAGTTCAGCGGTTATTGCACCTAATGAATGTGGAAATGGACCAAGAATATGCCTTCAGTCTTTTTCAG
GCAGCAGACACGTCCCAGTCTGGAACCCTGGAAGGAGAAGAATTCGTACAGTTCTATAAGGCATTGACTAAACGTGCTGAGGTGCAGGAA
CTGTTTGAAAGTTTTTCAGCTGATGGGCAGAAGCTGACTCTGCTGGAATTTTTGGATTTCCTCCAAGAGGAGCAGAAGGAGAGAGACTGC
ACCTCTGAGCTTGCTCTGGAACTCATTGACCGCTATGAACCTTCAGACAGTGGAACACCTGTCCATTGAAGATTTCACTCAGGCCTTTGG

>In-frame_PLCD4_ENST00000432688_chr2_219487601_+_VIL1_ENST00000248444_chr2_219313946_+_886nt
ATGGCGTCCCTGCTGCAAGACCAGCTGACCACTGATCAGGACTTGCTGCTGATGCAGGAAGGCATGCCGATGCGCAAGGTGAGGTCCAAA
AGCTGGAAGAAGCTAAGATACTTCAGACTTCAGAATGACGGCATGACAGTCTGGCATGCACGGCAGGCCAGGGGCAGTGCCAAGCCCAGC
TTCTCAATCTCTGATGTGGAGACAATACGTAATGGCCATGATTCCGAGTTGCTGCGTAGCCTGGCAGAGGAGCTCCCCCTGGAGCAGGGC
TTCACCATTGTCTTCCATGGCCGCCGCTCCAACCTGGACCTGATGGCCAACAGTGTTGAGGAGGCCCAGATATGGATGCGAGGGCTCCAG
CTGTTGGTGGATCTTGTCACCAGCATGGACCATCAGGAGCGCCTGGACCAATGGCTGAGCGATTGGTTTCAACGTGGAGACAAAAATCAG
GATGGTAAGATGAGTTTCCAAGAAGTTCAGCGGTTATTGCACCTAATGAATGTGGAAATGGACCAAGAATATGCCTTCAGTCTTTTTCAG
GCAGCAGACACGTCCCAGTCTGGAACCCTGGAAGGAGAAGAATTCGTACAGTTCTATAAGGCATTGACTAAACGTGCTGAGGTGCAGGAA
CTGTTTGAAAGTTTTTCAGCTGATGGGCAGAAGCTGACTCTGCTGGAATTTTTGGATTTCCTCCAAGAGGAGCAGAAGGAGAGAGACTGC
ACCTCTGAGCTTGCTCTGGAACTCATTGACCGCTATGAACCTTCAGACAGTGGAACACCTGTCCATTGAAGATTTCACTCAGGCCTTTGG

>In-frame_PLCD4_ENST00000432688_chr2_219487601_+_VIL1_ENST00000392114_chr2_219313946_+_886nt
ATGGCGTCCCTGCTGCAAGACCAGCTGACCACTGATCAGGACTTGCTGCTGATGCAGGAAGGCATGCCGATGCGCAAGGTGAGGTCCAAA
AGCTGGAAGAAGCTAAGATACTTCAGACTTCAGAATGACGGCATGACAGTCTGGCATGCACGGCAGGCCAGGGGCAGTGCCAAGCCCAGC
TTCTCAATCTCTGATGTGGAGACAATACGTAATGGCCATGATTCCGAGTTGCTGCGTAGCCTGGCAGAGGAGCTCCCCCTGGAGCAGGGC
TTCACCATTGTCTTCCATGGCCGCCGCTCCAACCTGGACCTGATGGCCAACAGTGTTGAGGAGGCCCAGATATGGATGCGAGGGCTCCAG
CTGTTGGTGGATCTTGTCACCAGCATGGACCATCAGGAGCGCCTGGACCAATGGCTGAGCGATTGGTTTCAACGTGGAGACAAAAATCAG
GATGGTAAGATGAGTTTCCAAGAAGTTCAGCGGTTATTGCACCTAATGAATGTGGAAATGGACCAAGAATATGCCTTCAGTCTTTTTCAG
GCAGCAGACACGTCCCAGTCTGGAACCCTGGAAGGAGAAGAATTCGTACAGTTCTATAAGGCATTGACTAAACGTGCTGAGGTGCAGGAA
CTGTTTGAAAGTTTTTCAGCTGATGGGCAGAAGCTGACTCTGCTGGAATTTTTGGATTTCCTCCAAGAGGAGCAGAAGGAGAGAGACTGC
ACCTCTGAGCTTGCTCTGGAACTCATTGACCGCTATGAACCTTCAGACAGTGGAACACCTGTCCATTGAAGATTTCACTCAGGCCTTTGG


* Fusion transcript sequences (Full-length transcript).
>In-frame_PLCD4_ENST00000450993_chr2_219487601_+_VIL1_ENST00000248444_chr2_219313946_+_5184nt
CTTCTCTCCCCACCCCACCCCCACTACTCCCTCACATTGACCAGTGTCCTGGGCCTTTAAGAGTTGGATGGGCTGGACTGGAGAGAGCTC
ACACCTCTCCCCTTCTTACTGCTTCCCTCCGGCTATAACTTGCCAGTCACAGCAGCCAGCTGCTGTAGAAGAGGGGAGGAAACAAGCCAG
TGCAAGGGGAGCAAAAGAGAAAAGGAGCCAGGCTGGGCTTCCTGATCCCACAGCATCGCAGAGCTCGGGAGGCACAGCTCACAGACACAG
GAAACACAGGACTGCTATTCTGCTCTCCTGCCCACGGTGATCTGGTGCCAGCTGGTGGAACAGTGGGTGATGGCGTCCCTGCTGCAAGAC
CAGCTGACCACTGATCAGGACTTGCTGCTGATGCAGGAAGGCATGCCGATGCGCAAGGTGAGGTCCAAAAGCTGGAAGAAGCTAAGATAC
TTCAGACTTCAGAATGACGGCATGACAGTCTGGCATGCACGGCAGGCCAGGGGCAGTGCCAAGCCCAGCTTCTCAATCTCTGATGTGGAG
ACAATACGTAATGGCCATGATTCCGAGTTGCTGCGTAGCCTGGCAGAGGAGCTCCCCCTGGAGCAGGGCTTCACCATTGTCTTCCATGGC
CGCCGCTCCAACCTGGACCTGATGGCCAACAGTGTTGAGGAGGCCCAGATATGGATGCGAGGGCTCCAGCTGTTGGTGGATCTTGTCACC
AGCATGGACCATCAGGAGCGCCTGGACCAATGGCTGAGCGATTGGTTTCAACGTGGAGACAAAAATCAGGATGGTAAGATGAGTTTCCAA
GAAGTTCAGCGGTTATTGCACCTAATGAATGTGGAAATGGACCAAGAATATGCCTTCAGTCTTTTTCAGGCAGCAGACACGTCCCAGTCT
GGAACCCTGGAAGGAGAAGAATTCGTACAGTTCTATAAGGCATTGACTAAACGTGCTGAGGTGCAGGAACTGTTTGAAAGTTTTTCAGCT
GATGGGCAGAAGCTGACTCTGCTGGAATTTTTGGATTTCCTCCAAGAGGAGCAGAAGGAGAGAGACTGCACCTCTGAGCTTGCTCTGGAA
CTCATTGACCGCTATGAACCTTCAGACAGTGGAACACCTGTCCATTGAAGATTTCACTCAGGCCTTTGGGATGACTCCAGCTGCCTTCTC
TGCTCTGCCTCGATGGAAGCAACAAAACCTCAAGAAAGAAAAAGGACTATTTTGAGAAGAGTAGCTGTGGTTGTAAAGCAGTACCCTACC
CTGATTGTAGGGTCTCATTTTCTCACCGATATTAGTCCTACACCAATTGAAGTGAAATTTTGCAGATGTGCCTATGAGCACAAACTTCTG
TGGCAAATGCCAGTTTTGTTTAATAATGTACCTATTCCTTCAGAAAGATGATACCCCAAAAGGAGCCTATGGTCCTCATTTCAACTTCTA
AGGTCGCTAGATTGTTTCTATCCTGAGGTATTGCATCAATTTTAATACTCCTATAGTTTTCTCTTCTTAGAAGAGCACAAACACTCCATG
GAACATTAGAGTTCTGAGGCACTACCCTAGCTTGTCCTCTATCATGACTCATTTTTATCTATGGCAGGTAGGCTGAAGCACTTTGCAGGT
TTACATCTTCCCCAGAGTAACAGCTTTTCCTTTTCACATATACTTTCCTTACTGCCTTACTCAGTGGGTAAGTTAAAGGGCTGAAGGAGA
GTTGAATGGTCCACAAGACTACCCTCTTAAGAGGTTTCACAAATTCCAAACAGTACCAGTGAGAGCAGCACTTCCACTGGGGCTAGGCTT
GAGACCTAAAGGCAAGTATGAAATGCATATGCTACTTCACTCCCTCTCCCAACCCTTAATAATGAGGCAAAGCAAGAGCCTAGTGAAGGC
CAATGCTAGGTTTACAAACTTACCCAGAAGCCTCTGCAAAGCTTCACAGGCTCCTCAGATGAAAATAACAGGAATCAATGGGGACTACGG
CCAGACACTGGTTTGCCATTCTGTTCCTTTTAAGAAGTAACAGTGCTGCAAGGAAGTCCATGTCAGAAAGCCAACAGAAGGTGATTTCCA
CAACTTTGAACAGGTTGTTACAAGTATCAGCAAGAATGTGTCCTTTTCAGAAATAACAGTCAAATCAAAGAAGGTTAATAAAGGCTTTAA
TTTCATACACACAAAAAAACTCTATGCATAATTTAAAAAGGAAACAAAAACAAAGAAAAACCGTAAAGGATACAGAGGAACAGTTCTGCT
AAAACACAGATAAAAGTGCCGCTCCATACAAAACATAAAGAATCAGAATCAAAAGTCACTCTGAACATAAAGAAAAAAAATCATCTCACA
AATAATGTGGCCACAGCTGCCAGAAAACCTGGTAGTGGCTCAATTAGGCAAAGTGTAGGAATCTCATTTTTGTTTTTCTCTCCTTAAGTT
TAAAGAAACAACAATGACAATAGGCCAGAGAAGTTAGGGAGGGAAAGAAAAGCTCAAAGGGAGGGAAACCTGGGGACAAGAGGTGTGCAC
ACCCACATGTGGTCTCACTCTTCACACAGGCCCACTATTTTTGAAGTAGACCAGTTTAGTTGACTGTTCTTCTTTGTTCTGGCATCTGAC
TGGACCAACCTGGAACCTGGTCCAGACCCTCACCCACTCTATTCTTATGCCAATGGACATACCTATACTTTGAACCTCTGTACTTTTAAG
AAAAGTCCAATGTTACAAAATCAAATGCTTATATTCAGACTGGCACACTTTTTAAATAAAAACTCCATACACCTCAGACATATAGCACAC
ATGGAGACAACTTACTAATTGTGTGTAAGTATGATACAATGAATGAGACTGCCTGAAGTCTAGTAATCAAAGCATGCCATAAGGTGAATG
ATTGTGGTTAAACACAGCAAAATAATTGTCACAAAACTTTCAAGGCCTAACAAATTAGAATTTTCCAATAAAAAATATATATTTTTTCAG
ATGTTAATAAGACATATCAGTAGAGACAAAATTAGGATTTTGAAGTAATGCAATAAAAAGATGTTGGAGGGCAGAAGTCTATTTAGTTTT
TGTATACACTTGCAAGAGTGCATTACTCAGTATAAAGCAAAATGGGGAGGAAAAAGACATCCATCCATTTTATTGGAACACTTTTATGTG
ACTTGAATCTGGTGTTAGGTTGTTGATTTTTCTAAAAATCTCCTATATATACAAAATCCATATGTACTTGGAGATCCAGCTGTTGCCCCC
TGTTTAAAACAAAAGACCACCTCGGGGGGTCAATTAAATTAAAAAGGCCCTCCAACCACCCTAAATGGGATAACTAAGAGTATCTACTGC
AGTCATTTCAGAGGACAGAGAAGGAAAATATTTTAATTTGCTTTAATATAACCTCTTTTCAGTAGATCACAAATGAGTTTACAAACTACT
TTTTTTTCTCTTTAATTTAGGTGTTTGCAGATAATTTTCATTATATCCGTAGCTGTATGTGTGTATAGTTACATAATGGTAACTACACAC
GATACAGAAGAATCAGTAAATTCATGGATTATTTTGCTGAGGTTTTAAATTTTAAAGCCTCTGTTTCAGAATTTTATACTTGATCAAGGA
GAAAAATAAATGTGTAGTCTAACATTTGCTTTCTGGAGTTAATTAACTGATCTGTAAGAACCACTGCATATGTCTTAAAATGTAAACATA
TTTACATTTGTTGTATTTGTTATTGAGCCTTTAAGGTTAGGCCCAGAATGAACAGACCATAGCAAGTAAACAAATAATTTTTAGAATCAA
AGTATTAATAGAAGACCAGTTCATGGATTTGCTTATTCTATCCTGCTGAGACAAAACTCATGAGTGTGCACACACATGTGAATATATCCC
TACGAAACAGTCTATCTTCTCATAGGCTTAAATTATAGTCATGGCTATTAAAGAAATTAACAGCATCCAGCCACATGCAACTTTCCAACC
TTCAGTACTATTAGGTGATTAAAATCAACAAATATGAAGTTTAGTTCATTTTTCCCTTAAAATTCCAACAAAGATCAAAAGGTTGTATCT
AGAACTAATTGCCATCAAGTTCCAATTCAATGTCATTTAAAGTAATGTAACCACACATTTGGTATTTTCAATAGGAAGGTTAATTAGGTA
TTGTGCAAACTGCCTGCAACGGAAGCACTCAGTCCTTATCTAACTTGTCCCTTCCTGGCCCCAACATGCTAACTGCCCCATCCCCAATTC
TGGGCAAACTGATCACAATGTGCAAAAAATAATATATTATCTATTTATAATTTTAAAATATATACAGCCAGCTCAAAAACAACAACAAAC
CCCATCAACATAGTCCAGCTGAAATCTCCACTGGTAGTCAAAGAAGTAGATTAAAGGAGTAAAGGAAGGAGAAGGCTGATAGGGCCACAA
GAATGGACAGACATCAAGTAAAATTTGAGTCCCAAACATGCAAGTACATGAGCAGTGAGATAACTTATATATTCCAATAACCTATTTTCA
ACAACTCCTGCCCAAGACATGAAGATCAAATCAGGTTTCTGAGGTAAGTGTACTTCTAAACCATACACACATGAAAGCTATGAAAGCAAT
TCAAATGAGGCTGCTTCATGAGGCAATCTAGACTTATGGCATTATTTCTACTTTTCTCCATGTTTTAATTGCAGCCTGCACTTTAAATCT
TTCCCAATAATTTTTAACAGTGCCTCTCAAATGCAAAGACACGTAAAAGAATTAATAACTAGCCAAAGAATTTTATCACCGCTTCACTCA
TTTATAAGAAAACCAATTATTTCCAAGCAAAATCAAACCAAACCAAAGAGGCTCCTGGTAGAAATGAAACAAAACTTTAAAGCTAGTTTT
AAAACAAATATTTTCCTCTGCTCTAAACTACTCTGGCGTTTTCTACCACTCTACCATTTTGGAACATTCATTACAATAAGGTATATAGGT
AGATGGTAGGAGGCAAAGCATTTATCAGTAGTTGAGCAAAACTGCTGAGGCCATTTATAATTCAAAGAATGAAAACTTAGAATAGTTTAC
TACATTAGAATACATCCAAGTTCCAAGAGTAGGACTGGAGCTCTCTTAAGGCAATCTTTCAGAAAAGATGTTGCATCTTCTGTGATGATG

>In-frame_PLCD4_ENST00000450993_chr2_219487601_+_VIL1_ENST00000392114_chr2_219313946_+_1413nt
CTTCTCTCCCCACCCCACCCCCACTACTCCCTCACATTGACCAGTGTCCTGGGCCTTTAAGAGTTGGATGGGCTGGACTGGAGAGAGCTC
ACACCTCTCCCCTTCTTACTGCTTCCCTCCGGCTATAACTTGCCAGTCACAGCAGCCAGCTGCTGTAGAAGAGGGGAGGAAACAAGCCAG
TGCAAGGGGAGCAAAAGAGAAAAGGAGCCAGGCTGGGCTTCCTGATCCCACAGCATCGCAGAGCTCGGGAGGCACAGCTCACAGACACAG
GAAACACAGGACTGCTATTCTGCTCTCCTGCCCACGGTGATCTGGTGCCAGCTGGTGGAACAGTGGGTGATGGCGTCCCTGCTGCAAGAC
CAGCTGACCACTGATCAGGACTTGCTGCTGATGCAGGAAGGCATGCCGATGCGCAAGGTGAGGTCCAAAAGCTGGAAGAAGCTAAGATAC
TTCAGACTTCAGAATGACGGCATGACAGTCTGGCATGCACGGCAGGCCAGGGGCAGTGCCAAGCCCAGCTTCTCAATCTCTGATGTGGAG
ACAATACGTAATGGCCATGATTCCGAGTTGCTGCGTAGCCTGGCAGAGGAGCTCCCCCTGGAGCAGGGCTTCACCATTGTCTTCCATGGC
CGCCGCTCCAACCTGGACCTGATGGCCAACAGTGTTGAGGAGGCCCAGATATGGATGCGAGGGCTCCAGCTGTTGGTGGATCTTGTCACC
AGCATGGACCATCAGGAGCGCCTGGACCAATGGCTGAGCGATTGGTTTCAACGTGGAGACAAAAATCAGGATGGTAAGATGAGTTTCCAA
GAAGTTCAGCGGTTATTGCACCTAATGAATGTGGAAATGGACCAAGAATATGCCTTCAGTCTTTTTCAGGCAGCAGACACGTCCCAGTCT
GGAACCCTGGAAGGAGAAGAATTCGTACAGTTCTATAAGGCATTGACTAAACGTGCTGAGGTGCAGGAACTGTTTGAAAGTTTTTCAGCT
GATGGGCAGAAGCTGACTCTGCTGGAATTTTTGGATTTCCTCCAAGAGGAGCAGAAGGAGAGAGACTGCACCTCTGAGCTTGCTCTGGAA
CTCATTGACCGCTATGAACCTTCAGACAGTGGAACACCTGTCCATTGAAGATTTCACTCAGGCCTTTGGGATGACTCCAGCTGCCTTCTC
TGCTCTGCCTCGATGGAAGCAACAAAACCTCAAGAAAGAAAAAGGACTATTTTGAGAAGAGTAGCTGTGGTTGTAAAGCAGTACCCTACC
CTGATTGTAGGGTCTCATTTTCTCACCGATATTAGTCCTACACCAATTGAAGTGAAATTTTGCAGATGTGCCTATGAGCACAAACTTCTG

>In-frame_PLCD4_ENST00000417849_chr2_219487601_+_VIL1_ENST00000248444_chr2_219313946_+_5030nt
GTAGAAGAGGGGAGGAAACAAGCCAGTGCAAGGGGAGCAAAAGAGAAAAGGAGCCAGGCTGGGCTTCCTGATCCCACAGCATCGCAGAGC
TCGGGAGGCACAGCTCACAGACACAGGAAACACAGGACTGCTATTCTGCTCTCCTGCCCACGGTGATCTGGTGCCAGCTGGTGGAACAGT
GGGTGATGGCGTCCCTGCTGCAAGACCAGCTGACCACTGATCAGGACTTGCTGCTGATGCAGGAAGGCATGCCGATGCGCAAGGTGAGGT
CCAAAAGCTGGAAGAAGCTAAGATACTTCAGACTTCAGAATGACGGCATGACAGTCTGGCATGCACGGCAGGCCAGGGGCAGTGCCAAGC
CCAGCTTCTCAATCTCTGATGTGGAGACAATACGTAATGGCCATGATTCCGAGTTGCTGCGTAGCCTGGCAGAGGAGCTCCCCCTGGAGC
AGGGCTTCACCATTGTCTTCCATGGCCGCCGCTCCAACCTGGACCTGATGGCCAACAGTGTTGAGGAGGCCCAGATATGGATGCGAGGGC
TCCAGCTGTTGGTGGATCTTGTCACCAGCATGGACCATCAGGAGCGCCTGGACCAATGGCTGAGCGATTGGTTTCAACGTGGAGACAAAA
ATCAGGATGGTAAGATGAGTTTCCAAGAAGTTCAGCGGTTATTGCACCTAATGAATGTGGAAATGGACCAAGAATATGCCTTCAGTCTTT
TTCAGGCAGCAGACACGTCCCAGTCTGGAACCCTGGAAGGAGAAGAATTCGTACAGTTCTATAAGGCATTGACTAAACGTGCTGAGGTGC
AGGAACTGTTTGAAAGTTTTTCAGCTGATGGGCAGAAGCTGACTCTGCTGGAATTTTTGGATTTCCTCCAAGAGGAGCAGAAGGAGAGAG
ACTGCACCTCTGAGCTTGCTCTGGAACTCATTGACCGCTATGAACCTTCAGACAGTGGAACACCTGTCCATTGAAGATTTCACTCAGGCC
TTTGGGATGACTCCAGCTGCCTTCTCTGCTCTGCCTCGATGGAAGCAACAAAACCTCAAGAAAGAAAAAGGACTATTTTGAGAAGAGTAG
CTGTGGTTGTAAAGCAGTACCCTACCCTGATTGTAGGGTCTCATTTTCTCACCGATATTAGTCCTACACCAATTGAAGTGAAATTTTGCA
GATGTGCCTATGAGCACAAACTTCTGTGGCAAATGCCAGTTTTGTTTAATAATGTACCTATTCCTTCAGAAAGATGATACCCCAAAAGGA
GCCTATGGTCCTCATTTCAACTTCTAAGGTCGCTAGATTGTTTCTATCCTGAGGTATTGCATCAATTTTAATACTCCTATAGTTTTCTCT
TCTTAGAAGAGCACAAACACTCCATGGAACATTAGAGTTCTGAGGCACTACCCTAGCTTGTCCTCTATCATGACTCATTTTTATCTATGG
CAGGTAGGCTGAAGCACTTTGCAGGTTTACATCTTCCCCAGAGTAACAGCTTTTCCTTTTCACATATACTTTCCTTACTGCCTTACTCAG
TGGGTAAGTTAAAGGGCTGAAGGAGAGTTGAATGGTCCACAAGACTACCCTCTTAAGAGGTTTCACAAATTCCAAACAGTACCAGTGAGA
GCAGCACTTCCACTGGGGCTAGGCTTGAGACCTAAAGGCAAGTATGAAATGCATATGCTACTTCACTCCCTCTCCCAACCCTTAATAATG
AGGCAAAGCAAGAGCCTAGTGAAGGCCAATGCTAGGTTTACAAACTTACCCAGAAGCCTCTGCAAAGCTTCACAGGCTCCTCAGATGAAA
ATAACAGGAATCAATGGGGACTACGGCCAGACACTGGTTTGCCATTCTGTTCCTTTTAAGAAGTAACAGTGCTGCAAGGAAGTCCATGTC
AGAAAGCCAACAGAAGGTGATTTCCACAACTTTGAACAGGTTGTTACAAGTATCAGCAAGAATGTGTCCTTTTCAGAAATAACAGTCAAA
TCAAAGAAGGTTAATAAAGGCTTTAATTTCATACACACAAAAAAACTCTATGCATAATTTAAAAAGGAAACAAAAACAAAGAAAAACCGT
AAAGGATACAGAGGAACAGTTCTGCTAAAACACAGATAAAAGTGCCGCTCCATACAAAACATAAAGAATCAGAATCAAAAGTCACTCTGA
ACATAAAGAAAAAAAATCATCTCACAAATAATGTGGCCACAGCTGCCAGAAAACCTGGTAGTGGCTCAATTAGGCAAAGTGTAGGAATCT
CATTTTTGTTTTTCTCTCCTTAAGTTTAAAGAAACAACAATGACAATAGGCCAGAGAAGTTAGGGAGGGAAAGAAAAGCTCAAAGGGAGG
GAAACCTGGGGACAAGAGGTGTGCACACCCACATGTGGTCTCACTCTTCACACAGGCCCACTATTTTTGAAGTAGACCAGTTTAGTTGAC
TGTTCTTCTTTGTTCTGGCATCTGACTGGACCAACCTGGAACCTGGTCCAGACCCTCACCCACTCTATTCTTATGCCAATGGACATACCT
ATACTTTGAACCTCTGTACTTTTAAGAAAAGTCCAATGTTACAAAATCAAATGCTTATATTCAGACTGGCACACTTTTTAAATAAAAACT
CCATACACCTCAGACATATAGCACACATGGAGACAACTTACTAATTGTGTGTAAGTATGATACAATGAATGAGACTGCCTGAAGTCTAGT
AATCAAAGCATGCCATAAGGTGAATGATTGTGGTTAAACACAGCAAAATAATTGTCACAAAACTTTCAAGGCCTAACAAATTAGAATTTT
CCAATAAAAAATATATATTTTTTCAGATGTTAATAAGACATATCAGTAGAGACAAAATTAGGATTTTGAAGTAATGCAATAAAAAGATGT
TGGAGGGCAGAAGTCTATTTAGTTTTTGTATACACTTGCAAGAGTGCATTACTCAGTATAAAGCAAAATGGGGAGGAAAAAGACATCCAT
CCATTTTATTGGAACACTTTTATGTGACTTGAATCTGGTGTTAGGTTGTTGATTTTTCTAAAAATCTCCTATATATACAAAATCCATATG
TACTTGGAGATCCAGCTGTTGCCCCCTGTTTAAAACAAAAGACCACCTCGGGGGGTCAATTAAATTAAAAAGGCCCTCCAACCACCCTAA
ATGGGATAACTAAGAGTATCTACTGCAGTCATTTCAGAGGACAGAGAAGGAAAATATTTTAATTTGCTTTAATATAACCTCTTTTCAGTA
GATCACAAATGAGTTTACAAACTACTTTTTTTTCTCTTTAATTTAGGTGTTTGCAGATAATTTTCATTATATCCGTAGCTGTATGTGTGT
ATAGTTACATAATGGTAACTACACACGATACAGAAGAATCAGTAAATTCATGGATTATTTTGCTGAGGTTTTAAATTTTAAAGCCTCTGT
TTCAGAATTTTATACTTGATCAAGGAGAAAAATAAATGTGTAGTCTAACATTTGCTTTCTGGAGTTAATTAACTGATCTGTAAGAACCAC
TGCATATGTCTTAAAATGTAAACATATTTACATTTGTTGTATTTGTTATTGAGCCTTTAAGGTTAGGCCCAGAATGAACAGACCATAGCA
AGTAAACAAATAATTTTTAGAATCAAAGTATTAATAGAAGACCAGTTCATGGATTTGCTTATTCTATCCTGCTGAGACAAAACTCATGAG
TGTGCACACACATGTGAATATATCCCTACGAAACAGTCTATCTTCTCATAGGCTTAAATTATAGTCATGGCTATTAAAGAAATTAACAGC
ATCCAGCCACATGCAACTTTCCAACCTTCAGTACTATTAGGTGATTAAAATCAACAAATATGAAGTTTAGTTCATTTTTCCCTTAAAATT
CCAACAAAGATCAAAAGGTTGTATCTAGAACTAATTGCCATCAAGTTCCAATTCAATGTCATTTAAAGTAATGTAACCACACATTTGGTA
TTTTCAATAGGAAGGTTAATTAGGTATTGTGCAAACTGCCTGCAACGGAAGCACTCAGTCCTTATCTAACTTGTCCCTTCCTGGCCCCAA
CATGCTAACTGCCCCATCCCCAATTCTGGGCAAACTGATCACAATGTGCAAAAAATAATATATTATCTATTTATAATTTTAAAATATATA
CAGCCAGCTCAAAAACAACAACAAACCCCATCAACATAGTCCAGCTGAAATCTCCACTGGTAGTCAAAGAAGTAGATTAAAGGAGTAAAG
GAAGGAGAAGGCTGATAGGGCCACAAGAATGGACAGACATCAAGTAAAATTTGAGTCCCAAACATGCAAGTACATGAGCAGTGAGATAAC
TTATATATTCCAATAACCTATTTTCAACAACTCCTGCCCAAGACATGAAGATCAAATCAGGTTTCTGAGGTAAGTGTACTTCTAAACCAT
ACACACATGAAAGCTATGAAAGCAATTCAAATGAGGCTGCTTCATGAGGCAATCTAGACTTATGGCATTATTTCTACTTTTCTCCATGTT
TTAATTGCAGCCTGCACTTTAAATCTTTCCCAATAATTTTTAACAGTGCCTCTCAAATGCAAAGACACGTAAAAGAATTAATAACTAGCC
AAAGAATTTTATCACCGCTTCACTCATTTATAAGAAAACCAATTATTTCCAAGCAAAATCAAACCAAACCAAAGAGGCTCCTGGTAGAAA
TGAAACAAAACTTTAAAGCTAGTTTTAAAACAAATATTTTCCTCTGCTCTAAACTACTCTGGCGTTTTCTACCACTCTACCATTTTGGAA
CATTCATTACAATAAGGTATATAGGTAGATGGTAGGAGGCAAAGCATTTATCAGTAGTTGAGCAAAACTGCTGAGGCCATTTATAATTCA
AAGAATGAAAACTTAGAATAGTTTACTACATTAGAATACATCCAAGTTCCAAGAGTAGGACTGGAGCTCTCTTAAGGCAATCTTTCAGAA

>In-frame_PLCD4_ENST00000417849_chr2_219487601_+_VIL1_ENST00000392114_chr2_219313946_+_1259nt
GTAGAAGAGGGGAGGAAACAAGCCAGTGCAAGGGGAGCAAAAGAGAAAAGGAGCCAGGCTGGGCTTCCTGATCCCACAGCATCGCAGAGC
TCGGGAGGCACAGCTCACAGACACAGGAAACACAGGACTGCTATTCTGCTCTCCTGCCCACGGTGATCTGGTGCCAGCTGGTGGAACAGT
GGGTGATGGCGTCCCTGCTGCAAGACCAGCTGACCACTGATCAGGACTTGCTGCTGATGCAGGAAGGCATGCCGATGCGCAAGGTGAGGT
CCAAAAGCTGGAAGAAGCTAAGATACTTCAGACTTCAGAATGACGGCATGACAGTCTGGCATGCACGGCAGGCCAGGGGCAGTGCCAAGC
CCAGCTTCTCAATCTCTGATGTGGAGACAATACGTAATGGCCATGATTCCGAGTTGCTGCGTAGCCTGGCAGAGGAGCTCCCCCTGGAGC
AGGGCTTCACCATTGTCTTCCATGGCCGCCGCTCCAACCTGGACCTGATGGCCAACAGTGTTGAGGAGGCCCAGATATGGATGCGAGGGC
TCCAGCTGTTGGTGGATCTTGTCACCAGCATGGACCATCAGGAGCGCCTGGACCAATGGCTGAGCGATTGGTTTCAACGTGGAGACAAAA
ATCAGGATGGTAAGATGAGTTTCCAAGAAGTTCAGCGGTTATTGCACCTAATGAATGTGGAAATGGACCAAGAATATGCCTTCAGTCTTT
TTCAGGCAGCAGACACGTCCCAGTCTGGAACCCTGGAAGGAGAAGAATTCGTACAGTTCTATAAGGCATTGACTAAACGTGCTGAGGTGC
AGGAACTGTTTGAAAGTTTTTCAGCTGATGGGCAGAAGCTGACTCTGCTGGAATTTTTGGATTTCCTCCAAGAGGAGCAGAAGGAGAGAG
ACTGCACCTCTGAGCTTGCTCTGGAACTCATTGACCGCTATGAACCTTCAGACAGTGGAACACCTGTCCATTGAAGATTTCACTCAGGCC
TTTGGGATGACTCCAGCTGCCTTCTCTGCTCTGCCTCGATGGAAGCAACAAAACCTCAAGAAAGAAAAAGGACTATTTTGAGAAGAGTAG
CTGTGGTTGTAAAGCAGTACCCTACCCTGATTGTAGGGTCTCATTTTCTCACCGATATTAGTCCTACACCAATTGAAGTGAAATTTTGCA

>In-frame_PLCD4_ENST00000432688_chr2_219487601_+_VIL1_ENST00000248444_chr2_219313946_+_5087nt
AGAGAAAAGTGAGGCTGAGCAGAGGGACACGCATGCTACTGAGTTCTGAACCCAAGTGTCCTCCCTTCTGGACCACAGTCTCAAAATTCT
CAAAGGAGATGAGACTCAGAGCCATTGCGAATTAGTGGAGTCAAAAGAGGGAACCAACTGGAAGAGGTGATGGGGAGAAGGGATGAGGAG
AAGGAAGAGAAGAGGAGAGACTGACCTAGGTGATCTGGTGCCAGCTGGTGGAACAGTGGGTGATGGCGTCCCTGCTGCAAGACCAGCTGA
CCACTGATCAGGACTTGCTGCTGATGCAGGAAGGCATGCCGATGCGCAAGGTGAGGTCCAAAAGCTGGAAGAAGCTAAGATACTTCAGAC
TTCAGAATGACGGCATGACAGTCTGGCATGCACGGCAGGCCAGGGGCAGTGCCAAGCCCAGCTTCTCAATCTCTGATGTGGAGACAATAC
GTAATGGCCATGATTCCGAGTTGCTGCGTAGCCTGGCAGAGGAGCTCCCCCTGGAGCAGGGCTTCACCATTGTCTTCCATGGCCGCCGCT
CCAACCTGGACCTGATGGCCAACAGTGTTGAGGAGGCCCAGATATGGATGCGAGGGCTCCAGCTGTTGGTGGATCTTGTCACCAGCATGG
ACCATCAGGAGCGCCTGGACCAATGGCTGAGCGATTGGTTTCAACGTGGAGACAAAAATCAGGATGGTAAGATGAGTTTCCAAGAAGTTC
AGCGGTTATTGCACCTAATGAATGTGGAAATGGACCAAGAATATGCCTTCAGTCTTTTTCAGGCAGCAGACACGTCCCAGTCTGGAACCC
TGGAAGGAGAAGAATTCGTACAGTTCTATAAGGCATTGACTAAACGTGCTGAGGTGCAGGAACTGTTTGAAAGTTTTTCAGCTGATGGGC
AGAAGCTGACTCTGCTGGAATTTTTGGATTTCCTCCAAGAGGAGCAGAAGGAGAGAGACTGCACCTCTGAGCTTGCTCTGGAACTCATTG
ACCGCTATGAACCTTCAGACAGTGGAACACCTGTCCATTGAAGATTTCACTCAGGCCTTTGGGATGACTCCAGCTGCCTTCTCTGCTCTG
CCTCGATGGAAGCAACAAAACCTCAAGAAAGAAAAAGGACTATTTTGAGAAGAGTAGCTGTGGTTGTAAAGCAGTACCCTACCCTGATTG
TAGGGTCTCATTTTCTCACCGATATTAGTCCTACACCAATTGAAGTGAAATTTTGCAGATGTGCCTATGAGCACAAACTTCTGTGGCAAA
TGCCAGTTTTGTTTAATAATGTACCTATTCCTTCAGAAAGATGATACCCCAAAAGGAGCCTATGGTCCTCATTTCAACTTCTAAGGTCGC
TAGATTGTTTCTATCCTGAGGTATTGCATCAATTTTAATACTCCTATAGTTTTCTCTTCTTAGAAGAGCACAAACACTCCATGGAACATT
AGAGTTCTGAGGCACTACCCTAGCTTGTCCTCTATCATGACTCATTTTTATCTATGGCAGGTAGGCTGAAGCACTTTGCAGGTTTACATC
TTCCCCAGAGTAACAGCTTTTCCTTTTCACATATACTTTCCTTACTGCCTTACTCAGTGGGTAAGTTAAAGGGCTGAAGGAGAGTTGAAT
GGTCCACAAGACTACCCTCTTAAGAGGTTTCACAAATTCCAAACAGTACCAGTGAGAGCAGCACTTCCACTGGGGCTAGGCTTGAGACCT
AAAGGCAAGTATGAAATGCATATGCTACTTCACTCCCTCTCCCAACCCTTAATAATGAGGCAAAGCAAGAGCCTAGTGAAGGCCAATGCT
AGGTTTACAAACTTACCCAGAAGCCTCTGCAAAGCTTCACAGGCTCCTCAGATGAAAATAACAGGAATCAATGGGGACTACGGCCAGACA
CTGGTTTGCCATTCTGTTCCTTTTAAGAAGTAACAGTGCTGCAAGGAAGTCCATGTCAGAAAGCCAACAGAAGGTGATTTCCACAACTTT
GAACAGGTTGTTACAAGTATCAGCAAGAATGTGTCCTTTTCAGAAATAACAGTCAAATCAAAGAAGGTTAATAAAGGCTTTAATTTCATA
CACACAAAAAAACTCTATGCATAATTTAAAAAGGAAACAAAAACAAAGAAAAACCGTAAAGGATACAGAGGAACAGTTCTGCTAAAACAC
AGATAAAAGTGCCGCTCCATACAAAACATAAAGAATCAGAATCAAAAGTCACTCTGAACATAAAGAAAAAAAATCATCTCACAAATAATG
TGGCCACAGCTGCCAGAAAACCTGGTAGTGGCTCAATTAGGCAAAGTGTAGGAATCTCATTTTTGTTTTTCTCTCCTTAAGTTTAAAGAA
ACAACAATGACAATAGGCCAGAGAAGTTAGGGAGGGAAAGAAAAGCTCAAAGGGAGGGAAACCTGGGGACAAGAGGTGTGCACACCCACA
TGTGGTCTCACTCTTCACACAGGCCCACTATTTTTGAAGTAGACCAGTTTAGTTGACTGTTCTTCTTTGTTCTGGCATCTGACTGGACCA
ACCTGGAACCTGGTCCAGACCCTCACCCACTCTATTCTTATGCCAATGGACATACCTATACTTTGAACCTCTGTACTTTTAAGAAAAGTC
CAATGTTACAAAATCAAATGCTTATATTCAGACTGGCACACTTTTTAAATAAAAACTCCATACACCTCAGACATATAGCACACATGGAGA
CAACTTACTAATTGTGTGTAAGTATGATACAATGAATGAGACTGCCTGAAGTCTAGTAATCAAAGCATGCCATAAGGTGAATGATTGTGG
TTAAACACAGCAAAATAATTGTCACAAAACTTTCAAGGCCTAACAAATTAGAATTTTCCAATAAAAAATATATATTTTTTCAGATGTTAA
TAAGACATATCAGTAGAGACAAAATTAGGATTTTGAAGTAATGCAATAAAAAGATGTTGGAGGGCAGAAGTCTATTTAGTTTTTGTATAC
ACTTGCAAGAGTGCATTACTCAGTATAAAGCAAAATGGGGAGGAAAAAGACATCCATCCATTTTATTGGAACACTTTTATGTGACTTGAA
TCTGGTGTTAGGTTGTTGATTTTTCTAAAAATCTCCTATATATACAAAATCCATATGTACTTGGAGATCCAGCTGTTGCCCCCTGTTTAA
AACAAAAGACCACCTCGGGGGGTCAATTAAATTAAAAAGGCCCTCCAACCACCCTAAATGGGATAACTAAGAGTATCTACTGCAGTCATT
TCAGAGGACAGAGAAGGAAAATATTTTAATTTGCTTTAATATAACCTCTTTTCAGTAGATCACAAATGAGTTTACAAACTACTTTTTTTT
CTCTTTAATTTAGGTGTTTGCAGATAATTTTCATTATATCCGTAGCTGTATGTGTGTATAGTTACATAATGGTAACTACACACGATACAG
AAGAATCAGTAAATTCATGGATTATTTTGCTGAGGTTTTAAATTTTAAAGCCTCTGTTTCAGAATTTTATACTTGATCAAGGAGAAAAAT
AAATGTGTAGTCTAACATTTGCTTTCTGGAGTTAATTAACTGATCTGTAAGAACCACTGCATATGTCTTAAAATGTAAACATATTTACAT
TTGTTGTATTTGTTATTGAGCCTTTAAGGTTAGGCCCAGAATGAACAGACCATAGCAAGTAAACAAATAATTTTTAGAATCAAAGTATTA
ATAGAAGACCAGTTCATGGATTTGCTTATTCTATCCTGCTGAGACAAAACTCATGAGTGTGCACACACATGTGAATATATCCCTACGAAA
CAGTCTATCTTCTCATAGGCTTAAATTATAGTCATGGCTATTAAAGAAATTAACAGCATCCAGCCACATGCAACTTTCCAACCTTCAGTA
CTATTAGGTGATTAAAATCAACAAATATGAAGTTTAGTTCATTTTTCCCTTAAAATTCCAACAAAGATCAAAAGGTTGTATCTAGAACTA
ATTGCCATCAAGTTCCAATTCAATGTCATTTAAAGTAATGTAACCACACATTTGGTATTTTCAATAGGAAGGTTAATTAGGTATTGTGCA
AACTGCCTGCAACGGAAGCACTCAGTCCTTATCTAACTTGTCCCTTCCTGGCCCCAACATGCTAACTGCCCCATCCCCAATTCTGGGCAA
ACTGATCACAATGTGCAAAAAATAATATATTATCTATTTATAATTTTAAAATATATACAGCCAGCTCAAAAACAACAACAAACCCCATCA
ACATAGTCCAGCTGAAATCTCCACTGGTAGTCAAAGAAGTAGATTAAAGGAGTAAAGGAAGGAGAAGGCTGATAGGGCCACAAGAATGGA
CAGACATCAAGTAAAATTTGAGTCCCAAACATGCAAGTACATGAGCAGTGAGATAACTTATATATTCCAATAACCTATTTTCAACAACTC
CTGCCCAAGACATGAAGATCAAATCAGGTTTCTGAGGTAAGTGTACTTCTAAACCATACACACATGAAAGCTATGAAAGCAATTCAAATG
AGGCTGCTTCATGAGGCAATCTAGACTTATGGCATTATTTCTACTTTTCTCCATGTTTTAATTGCAGCCTGCACTTTAAATCTTTCCCAA
TAATTTTTAACAGTGCCTCTCAAATGCAAAGACACGTAAAAGAATTAATAACTAGCCAAAGAATTTTATCACCGCTTCACTCATTTATAA
GAAAACCAATTATTTCCAAGCAAAATCAAACCAAACCAAAGAGGCTCCTGGTAGAAATGAAACAAAACTTTAAAGCTAGTTTTAAAACAA
ATATTTTCCTCTGCTCTAAACTACTCTGGCGTTTTCTACCACTCTACCATTTTGGAACATTCATTACAATAAGGTATATAGGTAGATGGT
AGGAGGCAAAGCATTTATCAGTAGTTGAGCAAAACTGCTGAGGCCATTTATAATTCAAAGAATGAAAACTTAGAATAGTTTACTACATTA
GAATACATCCAAGTTCCAAGAGTAGGACTGGAGCTCTCTTAAGGCAATCTTTCAGAAAAGATGTTGCATCTTCTGTGATGATGGTTTGTG

>In-frame_PLCD4_ENST00000432688_chr2_219487601_+_VIL1_ENST00000392114_chr2_219313946_+_1316nt
AGAGAAAAGTGAGGCTGAGCAGAGGGACACGCATGCTACTGAGTTCTGAACCCAAGTGTCCTCCCTTCTGGACCACAGTCTCAAAATTCT
CAAAGGAGATGAGACTCAGAGCCATTGCGAATTAGTGGAGTCAAAAGAGGGAACCAACTGGAAGAGGTGATGGGGAGAAGGGATGAGGAG
AAGGAAGAGAAGAGGAGAGACTGACCTAGGTGATCTGGTGCCAGCTGGTGGAACAGTGGGTGATGGCGTCCCTGCTGCAAGACCAGCTGA
CCACTGATCAGGACTTGCTGCTGATGCAGGAAGGCATGCCGATGCGCAAGGTGAGGTCCAAAAGCTGGAAGAAGCTAAGATACTTCAGAC
TTCAGAATGACGGCATGACAGTCTGGCATGCACGGCAGGCCAGGGGCAGTGCCAAGCCCAGCTTCTCAATCTCTGATGTGGAGACAATAC
GTAATGGCCATGATTCCGAGTTGCTGCGTAGCCTGGCAGAGGAGCTCCCCCTGGAGCAGGGCTTCACCATTGTCTTCCATGGCCGCCGCT
CCAACCTGGACCTGATGGCCAACAGTGTTGAGGAGGCCCAGATATGGATGCGAGGGCTCCAGCTGTTGGTGGATCTTGTCACCAGCATGG
ACCATCAGGAGCGCCTGGACCAATGGCTGAGCGATTGGTTTCAACGTGGAGACAAAAATCAGGATGGTAAGATGAGTTTCCAAGAAGTTC
AGCGGTTATTGCACCTAATGAATGTGGAAATGGACCAAGAATATGCCTTCAGTCTTTTTCAGGCAGCAGACACGTCCCAGTCTGGAACCC
TGGAAGGAGAAGAATTCGTACAGTTCTATAAGGCATTGACTAAACGTGCTGAGGTGCAGGAACTGTTTGAAAGTTTTTCAGCTGATGGGC
AGAAGCTGACTCTGCTGGAATTTTTGGATTTCCTCCAAGAGGAGCAGAAGGAGAGAGACTGCACCTCTGAGCTTGCTCTGGAACTCATTG
ACCGCTATGAACCTTCAGACAGTGGAACACCTGTCCATTGAAGATTTCACTCAGGCCTTTGGGATGACTCCAGCTGCCTTCTCTGCTCTG
CCTCGATGGAAGCAACAAAACCTCAAGAAAGAAAAAGGACTATTTTGAGAAGAGTAGCTGTGGTTGTAAAGCAGTACCCTACCCTGATTG
TAGGGTCTCATTTTCTCACCGATATTAGTCCTACACCAATTGAAGTGAAATTTTGCAGATGTGCCTATGAGCACAAACTTCTGTGGCAAA


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FusionGenePPI for PLCD4_VIL1


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors
PLCD4TRIM39, IPO11, APPVIL1TEX11, PPM1B, VCP, PTPRO, CHM, AVIL


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for PLCD4_VIL1


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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RelatedDiseases for PLCD4_VIL1


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource