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Fusion gene ID: 27487 |
FusionGeneSummary for PLCB1_WDFY3-AS2 |
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Fusion gene information | Fusion gene name: PLCB1_WDFY3-AS2 | Fusion gene ID: 27487 | Hgene | Tgene | Gene symbol | PLCB1 | WDFY3-AS2 | Gene ID | 23236 | 404201 |
Gene name | phospholipase C beta 1 | WDFY3 antisense RNA 2 | |
Synonyms | EIEE12|PI-PLC|PLC-154|PLC-I|PLC-beta-1|PLC154|PLCB1A|PLCB1B | C4orf12|FBI4|NCRNA00247 | |
Cytomap | 20p12.3 | 4q21.23 | |
Type of gene | protein-coding | ncRNA | |
Description | 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-11-phosphatidyl-D-myo-inositol-4,5-bisphosphateinositoltrisphosphohydrolasemonophosphatidylinositol phosphodiesterasephosphoinositidase Cphospholipase C, beta 1 (phosphoinositide-specific | WDFY3 antisense RNA 2 (non-protein coding) | |
Modification date | 20180519 | 20180408 | |
UniProtAcc | Q9NQ66 | ||
Ensembl transtripts involved in fusion gene | ENST00000378641, ENST00000338037, ENST00000378637, ENST00000494924, | ENST00000451762, | |
Fusion gene scores | * DoF score | 13 X 9 X 9=1053 | 1 X 1 X 1=1 |
# samples | 11 | 1 | |
** MAII score | log2(11/1053*10)=-3.25893000750106 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | log2(1/1*10)=3.32192809488736 | |
Context | PubMed: PLCB1 [Title/Abstract] AND WDFY3-AS2 [Title/Abstract] AND fusion [Title/Abstract] | ||
Functional or gene categories assigned by FusionGDB annotation |
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
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Partner | Gene | GO ID | GO term | PubMed ID |
Hgene | PLCB1 | GO:0035722 | interleukin-12-mediated signaling pathway | 11743656 |
Hgene | PLCB1 | GO:0035723 | interleukin-15-mediated signaling pathway | 11743656 |
Hgene | PLCB1 | GO:0046330 | positive regulation of JNK cascade | 9500449 |
Hgene | PLCB1 | GO:0070498 | interleukin-1-mediated signaling pathway | 8872139 |
![]() (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
TCGA | LD | OV | TCGA-25-2400-01A | PLCB1 | chr20 | 8131018 | + | WDFY3-AS2 | chr4 | 85925383 | + |
* LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
![]() * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
5CDS-3UTR | ENST00000378641 | ENST00000451762 | PLCB1 | chr20 | 8131018 | + | WDFY3-AS2 | chr4 | 85925383 | + |
5CDS-3UTR | ENST00000338037 | ENST00000451762 | PLCB1 | chr20 | 8131018 | + | WDFY3-AS2 | chr4 | 85925383 | + |
5CDS-3UTR | ENST00000378637 | ENST00000451762 | PLCB1 | chr20 | 8131018 | + | WDFY3-AS2 | chr4 | 85925383 | + |
intron-3UTR | ENST00000494924 | ENST00000451762 | PLCB1 | chr20 | 8131018 | + | WDFY3-AS2 | chr4 | 85925383 | + |
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FusionProtFeatures for PLCB1_WDFY3-AS2 |
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Hgene | Tgene |
PLCB1 | WDFY3-AS2 |
Lectin that binds to various sugars: galactose > mannose= fucose > N-acetylglucosamine > N-acetylgalactosamine(PubMed:10224141). Acts as a chemoattractant, probably involved inthe regulation of cell migration (PubMed:28301481).{ECO:0000269|PubMed:10224141, ECO:0000269|PubMed:28301481}. |
![]() * Minus value of BPloci means that the break pointn is located before the CDS. |
- In-frame and retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
- In-frame and not-retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
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FusionGeneSequence for PLCB1_WDFY3-AS2 |
![]() (nt: nucleotides, aa: amino acids) |
* Fusion amino acid sequences. |
* Fusion transcript sequences (only coding sequence (CDS) region). |
* Fusion transcript sequences (Full-length transcript). |
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FusionGenePPI for PLCB1_WDFY3-AS2 |
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Hgene | Hgene's interactors | Tgene | Tgene's interactors |
PLCB1 | TRPM7, SLC9A3R1, SPTBN1, KRIT1, PCF11, GNA11, GNAQ, PLCB1, CTBP1, CTBP2, TFCP2, CEP76, BTN2A1, PTGER3, GAN, DEF8 | WDFY3-AS2 |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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RelatedDrugs for PLCB1_WDFY3-AS2 |
![]() (DrugBank Version 5.1.0 2018-04-02) |
Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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RelatedDiseases for PLCB1_WDFY3-AS2 |
![]() (DisGeNet 4.0) |
Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
Hgene | PLCB1 | C0005586 | Bipolar Disorder | 1 | PSYGENET |
Hgene | PLCB1 | C0009375 | Colonic Neoplasms | 1 | CTD_human |
Hgene | PLCB1 | C0030193 | Pain | 1 | CTD_human |
Hgene | PLCB1 | C0036341 | Schizophrenia | 1 | CTD_human |
Hgene | PLCB1 | C0041696 | Unipolar Depression | 1 | PSYGENET |
Hgene | PLCB1 | C1269683 | Major Depressive Disorder | 1 | PSYGENET |
Hgene | PLCB1 | C3463824 | MYELODYSPLASTIC SYNDROME | 1 | CTD_human |