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Fusion gene ID: 27484 |
FusionGeneSummary for PLCB1_RBL1 |
 Fusion gene summary |
| Fusion gene information | Fusion gene name: PLCB1_RBL1 | Fusion gene ID: 27484 | Hgene | Tgene | Gene symbol | PLCB1 | RBL1 | Gene ID | 23236 | 5933 |
| Gene name | phospholipase C beta 1 | RB transcriptional corepressor like 1 | |
| Synonyms | EIEE12|PI-PLC|PLC-154|PLC-I|PLC-beta-1|PLC154|PLCB1A|PLCB1B | CP107|PRB1|p107 | |
| Cytomap | 20p12.3 | 20q11.23 | |
| Type of gene | protein-coding | protein-coding | |
| Description | 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-11-phosphatidyl-D-myo-inositol-4,5-bisphosphateinositoltrisphosphohydrolasemonophosphatidylinositol phosphodiesterasephosphoinositidase Cphospholipase C, beta 1 (phosphoinositide-specific | retinoblastoma-like protein 1107 kDa retinoblastoma-associated proteinretinoblastoma-like 1 | |
| Modification date | 20180519 | 20180523 | |
| UniProtAcc | Q9NQ66 | P28749 | |
| Ensembl transtripts involved in fusion gene | ENST00000378641, ENST00000338037, ENST00000378637, ENST00000494924, | ENST00000373664, ENST00000344359, ENST00000598590, | |
| Fusion gene scores | * DoF score | 13 X 9 X 9=1053 | 4 X 5 X 5=100 |
| # samples | 11 | 5 | |
| ** MAII score | log2(11/1053*10)=-3.25893000750106 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | log2(5/100*10)=-1 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | |
| Context | PubMed: PLCB1 [Title/Abstract] AND RBL1 [Title/Abstract] AND fusion [Title/Abstract] | ||
| Functional or gene categories assigned by FusionGDB annotation | Tumor suppressor gene involved fusion gene, in-frame but not retained their domain. Tumor suppressor gene involved fusion gene, retained protein feature but frameshift. DDR (DNA damage repair) gene involved fusion gene, in-frame but not retained their domain. | ||
| * DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
| Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Partner | Gene | GO ID | GO term | PubMed ID |
| Hgene | PLCB1 | GO:0035722 | interleukin-12-mediated signaling pathway | 11743656 |
| Hgene | PLCB1 | GO:0035723 | interleukin-15-mediated signaling pathway | 11743656 |
| Hgene | PLCB1 | GO:0046330 | positive regulation of JNK cascade | 9500449 |
| Hgene | PLCB1 | GO:0070498 | interleukin-1-mediated signaling pathway | 8872139 |
| Tgene | RBL1 | GO:0043550 | regulation of lipid kinase activity | 16286473 |
| Fusion gene information from three resources (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| TCGA | RV | LUSC | TCGA-22-A5C4-01A | PLCB1 | chr20 | 8131018 | + | RBL1 | chr20 | 35651229 | - |
| * LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
| Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| In-frame | ENST00000378641 | ENST00000373664 | PLCB1 | chr20 | 8131018 | + | RBL1 | chr20 | 35651229 | - |
| In-frame | ENST00000378641 | ENST00000344359 | PLCB1 | chr20 | 8131018 | + | RBL1 | chr20 | 35651229 | - |
| 5CDS-intron | ENST00000378641 | ENST00000598590 | PLCB1 | chr20 | 8131018 | + | RBL1 | chr20 | 35651229 | - |
| In-frame | ENST00000338037 | ENST00000373664 | PLCB1 | chr20 | 8131018 | + | RBL1 | chr20 | 35651229 | - |
| In-frame | ENST00000338037 | ENST00000344359 | PLCB1 | chr20 | 8131018 | + | RBL1 | chr20 | 35651229 | - |
| 5CDS-intron | ENST00000338037 | ENST00000598590 | PLCB1 | chr20 | 8131018 | + | RBL1 | chr20 | 35651229 | - |
| In-frame | ENST00000378637 | ENST00000373664 | PLCB1 | chr20 | 8131018 | + | RBL1 | chr20 | 35651229 | - |
| In-frame | ENST00000378637 | ENST00000344359 | PLCB1 | chr20 | 8131018 | + | RBL1 | chr20 | 35651229 | - |
| 5CDS-intron | ENST00000378637 | ENST00000598590 | PLCB1 | chr20 | 8131018 | + | RBL1 | chr20 | 35651229 | - |
| intron-3CDS | ENST00000494924 | ENST00000373664 | PLCB1 | chr20 | 8131018 | + | RBL1 | chr20 | 35651229 | - |
| intron-3CDS | ENST00000494924 | ENST00000344359 | PLCB1 | chr20 | 8131018 | + | RBL1 | chr20 | 35651229 | - |
| intron-intron | ENST00000494924 | ENST00000598590 | PLCB1 | chr20 | 8131018 | + | RBL1 | chr20 | 35651229 | - |
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FusionProtFeatures for PLCB1_RBL1 |
| Main function of each fusion partner protein. (from UniProt) |
| Hgene | Tgene |
| PLCB1 | RBL1 |
| Key regulator of entry into cell division. Directlyinvolved in heterochromatin formation by maintaining overallchromatin structure and, in particular, that of constitutiveheterochromatin by stabilizing histone methylation. Recruits andtargets histone methyltransferases KMT5B and KMT5C, leading toepigenetic transcriptional repression. Controls histone H4 'Lys-20' trimethylation. Probably acts as a transcription repressor byrecruiting chromatin-modifying enzymes to promoters. Potentinhibitor of E2F-mediated trans-activation. Forms a complex withadenovirus E1A and with SV40 large T antigen. May bind andmodulate functionally certain cellular proteins with which T andE1A compete for pocket binding. May act as a tumor suppressor. |
| Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at . * Minus value of BPloci means that the break pointn is located before the CDS. |
| - In-frame and retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
| - In-frame and not-retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
| Hgene | >PLCB1 | chr20:8131018 | chr20:35651229 | ENST00000338037 | + | 2 | 32 | 316_467 | 59 | 1217 | Domain | PI-PLC X-box |
| Hgene | >PLCB1 | chr20:8131018 | chr20:35651229 | ENST00000338037 | + | 2 | 32 | 540_656 | 59 | 1217 | Domain | PI-PLC Y-box |
| Hgene | >PLCB1 | chr20:8131018 | chr20:35651229 | ENST00000338037 | + | 2 | 32 | 663_761 | 59 | 1217 | Domain | C2 |
| Hgene | >PLCB1 | chr20:8131018 | chr20:35651229 | ENST00000378637 | + | 2 | 32 | 316_467 | 59 | 1174 | Domain | PI-PLC X-box |
| Hgene | >PLCB1 | chr20:8131018 | chr20:35651229 | ENST00000378637 | + | 2 | 32 | 540_656 | 59 | 1174 | Domain | PI-PLC Y-box |
| Hgene | >PLCB1 | chr20:8131018 | chr20:35651229 | ENST00000378637 | + | 2 | 32 | 663_761 | 59 | 1174 | Domain | C2 |
| Hgene | >PLCB1 | chr20:8131018 | chr20:35651229 | ENST00000378641 | + | 2 | 33 | 316_467 | 59 | 2075 | Domain | PI-PLC X-box |
| Hgene | >PLCB1 | chr20:8131018 | chr20:35651229 | ENST00000378641 | + | 2 | 33 | 540_656 | 59 | 2075 | Domain | PI-PLC Y-box |
| Hgene | >PLCB1 | chr20:8131018 | chr20:35651229 | ENST00000378641 | + | 2 | 33 | 663_761 | 59 | 2075 | Domain | C2 |
| Tgene | RBL1 | chr20:8131018 | chr20:35651229 | ENST00000344359 | - | 15 | 21 | 385_584 | 794 | 1015 | Region | Note=Domain A |
| Tgene | RBL1 | chr20:8131018 | chr20:35651229 | ENST00000344359 | - | 15 | 21 | 385_949 | 794 | 1015 | Region | Note=Pocket%3B binds T and E1A |
| Tgene | RBL1 | chr20:8131018 | chr20:35651229 | ENST00000344359 | - | 15 | 21 | 585_780 | 794 | 1015 | Region | Note=Spacer |
| Tgene | RBL1 | chr20:8131018 | chr20:35651229 | ENST00000344359 | - | 15 | 21 | 781_949 | 794 | 1015 | Region | Note=Domain B |
| Tgene | RBL1 | chr20:8131018 | chr20:35651229 | ENST00000373664 | - | 15 | 22 | 385_584 | 794 | 1069 | Region | Note=Domain A |
| Tgene | RBL1 | chr20:8131018 | chr20:35651229 | ENST00000373664 | - | 15 | 22 | 385_949 | 794 | 1069 | Region | Note=Pocket%3B binds T and E1A |
| Tgene | RBL1 | chr20:8131018 | chr20:35651229 | ENST00000373664 | - | 15 | 22 | 585_780 | 794 | 1069 | Region | Note=Spacer |
| Tgene | RBL1 | chr20:8131018 | chr20:35651229 | ENST00000373664 | - | 15 | 22 | 781_949 | 794 | 1069 | Region | Note=Domain B |
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FusionGeneSequence for PLCB1_RBL1 |
| For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. (nt: nucleotides, aa: amino acids) |
| * Fusion amino acid sequences. |
| >In-frame_PLCB1_ENST00000378641_chr20_8131018_+_RBL1_ENST00000373664_chr20_35651229_-_334aa MAGAQPGVHALQLKPVCVSDSLKKGTKFVKWDDDSTIVTPIILRTDPQGFFFYWTDQNKVYHLASVRLRDLCLKLDVSNELRRKIWTCFE FTLVHCPDLMKDRHLDQLLLCAFYIMAKVTKEERTFQEIMKSYRNQPQANSHVYRSVLLKSIPREVVAYNKNINDDFEMIDCDLEDATKT PDCSSGPVKEERGDLIKFYNTIYVGRVKSFALKYDLANQDHMMDAPPLSPFPHIKQQPGSPRRISQQHSIYISPHKNGSGLTPRSALLYK >In-frame_PLCB1_ENST00000378641_chr20_8131018_+_RBL1_ENST00000344359_chr20_35651229_-_280aa MAGAQPGVHALQLKPVCVSDSLKKGTKFVKWDDDSTIVTPIILRTDPQGFFFYWTDQNKVYHLASVRLRDLCLKLDVSNELRRKIWTCFE FTLVHCPDLMKDRHLDQLLLCAFYIMAKVTKEERTFQEIMKSYRNQPQANSHVYRSVLLKSIPREVVAYNKNINDDFEMIDCDLEDATKT PDCSSGPVKEERGDLIKFYNTIYVGRVKSFALKYDLANQDHMMDAPPLSPFPHIKQQPGSPRRISQQHSIYISPHKNGSGLTPRSALLYK >In-frame_PLCB1_ENST00000338037_chr20_8131018_+_RBL1_ENST00000373664_chr20_35651229_-_334aa MAGAQPGVHALQLKPVCVSDSLKKGTKFVKWDDDSTIVTPIILRTDPQGFFFYWTDQNKVYHLASVRLRDLCLKLDVSNELRRKIWTCFE FTLVHCPDLMKDRHLDQLLLCAFYIMAKVTKEERTFQEIMKSYRNQPQANSHVYRSVLLKSIPREVVAYNKNINDDFEMIDCDLEDATKT PDCSSGPVKEERGDLIKFYNTIYVGRVKSFALKYDLANQDHMMDAPPLSPFPHIKQQPGSPRRISQQHSIYISPHKNGSGLTPRSALLYK >In-frame_PLCB1_ENST00000338037_chr20_8131018_+_RBL1_ENST00000344359_chr20_35651229_-_280aa MAGAQPGVHALQLKPVCVSDSLKKGTKFVKWDDDSTIVTPIILRTDPQGFFFYWTDQNKVYHLASVRLRDLCLKLDVSNELRRKIWTCFE FTLVHCPDLMKDRHLDQLLLCAFYIMAKVTKEERTFQEIMKSYRNQPQANSHVYRSVLLKSIPREVVAYNKNINDDFEMIDCDLEDATKT PDCSSGPVKEERGDLIKFYNTIYVGRVKSFALKYDLANQDHMMDAPPLSPFPHIKQQPGSPRRISQQHSIYISPHKNGSGLTPRSALLYK >In-frame_PLCB1_ENST00000378637_chr20_8131018_+_RBL1_ENST00000373664_chr20_35651229_-_334aa MAGAQPGVHALQLKPVCVSDSLKKGTKFVKWDDDSTIVTPIILRTDPQGFFFYWTDQNKVYHLASVRLRDLCLKLDVSNELRRKIWTCFE FTLVHCPDLMKDRHLDQLLLCAFYIMAKVTKEERTFQEIMKSYRNQPQANSHVYRSVLLKSIPREVVAYNKNINDDFEMIDCDLEDATKT PDCSSGPVKEERGDLIKFYNTIYVGRVKSFALKYDLANQDHMMDAPPLSPFPHIKQQPGSPRRISQQHSIYISPHKNGSGLTPRSALLYK >In-frame_PLCB1_ENST00000378637_chr20_8131018_+_RBL1_ENST00000344359_chr20_35651229_-_280aa MAGAQPGVHALQLKPVCVSDSLKKGTKFVKWDDDSTIVTPIILRTDPQGFFFYWTDQNKVYHLASVRLRDLCLKLDVSNELRRKIWTCFE FTLVHCPDLMKDRHLDQLLLCAFYIMAKVTKEERTFQEIMKSYRNQPQANSHVYRSVLLKSIPREVVAYNKNINDDFEMIDCDLEDATKT PDCSSGPVKEERGDLIKFYNTIYVGRVKSFALKYDLANQDHMMDAPPLSPFPHIKQQPGSPRRISQQHSIYISPHKNGSGLTPRSALLYK |
| * Fusion transcript sequences (only coding sequence (CDS) region). |
| >In-frame_PLCB1_ENST00000378641_chr20_8131018_+_RBL1_ENST00000373664_chr20_35651229_-_1002nt ATGGCCGGGGCTCAACCCGGAGTGCACGCCTTGCAACTCAAGCCCGTGTGCGTGTCCGACAGCCTCAAGAAGGGCACCAAATTCGTCAAG TGGGATGATGACTCAACTATTGTTACTCCAATTATTTTGAGGACTGACCCTCAGGGATTTTTCTTTTACTGGACAGATCAAAACAAGGTC TATCATTTGGCAAGTGTACGCTTACGTGATCTATGTCTAAAACTGGATGTTTCAAATGAGTTACGAAGGAAGATATGGACGTGTTTTGAA TTCACTTTAGTTCACTGTCCTGATCTAATGAAAGACAGGCATTTGGATCAGCTCCTCCTTTGTGCCTTTTATATCATGGCAAAGGTAACA AAAGAAGAAAGAACTTTTCAAGAAATTATGAAAAGTTATAGGAATCAGCCCCAAGCTAATAGTCACGTATATAGAAGTGTTCTGCTGAAA AGTATTCCAAGAGAAGTTGTGGCATATAATAAAAATATAAATGATGACTTTGAAATGATAGATTGTGACTTAGAAGATGCTACAAAAACA CCTGACTGTTCCAGTGGACCAGTGAAAGAGGAAAGAGGTGATCTTATAAAATTTTACAATACAATATATGTAGGAAGAGTGAAGTCATTT GCACTGAAATACGACTTGGCGAATCAGGACCATATGATGGATGCTCCACCACTCTCTCCTTTTCCACATATTAAACAACAGCCAGGCTCA CCACGCCGCATTTCCCAGCAGCACTCCATTTATATTTCCCCGCACAAGAATGGGTCAGGCCTTACACCAAGAAGCGCTCTGCTGTACAAG TTCAATGGCAGCCCTTCTAAGAGTTTGAAAGATATCAACAACATGATAAGGCAAGGTGAGCAGAGAACCAAGAAGCGAGTAATAGCCATC GATAGTGATGCAGAATCCCCTGCCAAACGCGTCTGTCAAGAAAATGATGACGTTTTACTGAAACGACTACAGGATGTTGTCAGTGAAAGA >In-frame_PLCB1_ENST00000378641_chr20_8131018_+_RBL1_ENST00000344359_chr20_35651229_-_840nt ATGGCCGGGGCTCAACCCGGAGTGCACGCCTTGCAACTCAAGCCCGTGTGCGTGTCCGACAGCCTCAAGAAGGGCACCAAATTCGTCAAG TGGGATGATGACTCAACTATTGTTACTCCAATTATTTTGAGGACTGACCCTCAGGGATTTTTCTTTTACTGGACAGATCAAAACAAGGTC TATCATTTGGCAAGTGTACGCTTACGTGATCTATGTCTAAAACTGGATGTTTCAAATGAGTTACGAAGGAAGATATGGACGTGTTTTGAA TTCACTTTAGTTCACTGTCCTGATCTAATGAAAGACAGGCATTTGGATCAGCTCCTCCTTTGTGCCTTTTATATCATGGCAAAGGTAACA AAAGAAGAAAGAACTTTTCAAGAAATTATGAAAAGTTATAGGAATCAGCCCCAAGCTAATAGTCACGTATATAGAAGTGTTCTGCTGAAA AGTATTCCAAGAGAAGTTGTGGCATATAATAAAAATATAAATGATGACTTTGAAATGATAGATTGTGACTTAGAAGATGCTACAAAAACA CCTGACTGTTCCAGTGGACCAGTGAAAGAGGAAAGAGGTGATCTTATAAAATTTTACAATACAATATATGTAGGAAGAGTGAAGTCATTT GCACTGAAATACGACTTGGCGAATCAGGACCATATGATGGATGCTCCACCACTCTCTCCTTTTCCACATATTAAACAACAGCCAGGCTCA CCACGCCGCATTTCCCAGCAGCACTCCATTTATATTTCCCCGCACAAGAATGGGTCAGGCCTTACACCAAGAAGCGCTCTGCTGTACAAG >In-frame_PLCB1_ENST00000338037_chr20_8131018_+_RBL1_ENST00000373664_chr20_35651229_-_1002nt ATGGCCGGGGCTCAACCCGGAGTGCACGCCTTGCAACTCAAGCCCGTGTGCGTGTCCGACAGCCTCAAGAAGGGCACCAAATTCGTCAAG TGGGATGATGACTCAACTATTGTTACTCCAATTATTTTGAGGACTGACCCTCAGGGATTTTTCTTTTACTGGACAGATCAAAACAAGGTC TATCATTTGGCAAGTGTACGCTTACGTGATCTATGTCTAAAACTGGATGTTTCAAATGAGTTACGAAGGAAGATATGGACGTGTTTTGAA TTCACTTTAGTTCACTGTCCTGATCTAATGAAAGACAGGCATTTGGATCAGCTCCTCCTTTGTGCCTTTTATATCATGGCAAAGGTAACA AAAGAAGAAAGAACTTTTCAAGAAATTATGAAAAGTTATAGGAATCAGCCCCAAGCTAATAGTCACGTATATAGAAGTGTTCTGCTGAAA AGTATTCCAAGAGAAGTTGTGGCATATAATAAAAATATAAATGATGACTTTGAAATGATAGATTGTGACTTAGAAGATGCTACAAAAACA CCTGACTGTTCCAGTGGACCAGTGAAAGAGGAAAGAGGTGATCTTATAAAATTTTACAATACAATATATGTAGGAAGAGTGAAGTCATTT GCACTGAAATACGACTTGGCGAATCAGGACCATATGATGGATGCTCCACCACTCTCTCCTTTTCCACATATTAAACAACAGCCAGGCTCA CCACGCCGCATTTCCCAGCAGCACTCCATTTATATTTCCCCGCACAAGAATGGGTCAGGCCTTACACCAAGAAGCGCTCTGCTGTACAAG TTCAATGGCAGCCCTTCTAAGAGTTTGAAAGATATCAACAACATGATAAGGCAAGGTGAGCAGAGAACCAAGAAGCGAGTAATAGCCATC GATAGTGATGCAGAATCCCCTGCCAAACGCGTCTGTCAAGAAAATGATGACGTTTTACTGAAACGACTACAGGATGTTGTCAGTGAAAGA >In-frame_PLCB1_ENST00000338037_chr20_8131018_+_RBL1_ENST00000344359_chr20_35651229_-_840nt ATGGCCGGGGCTCAACCCGGAGTGCACGCCTTGCAACTCAAGCCCGTGTGCGTGTCCGACAGCCTCAAGAAGGGCACCAAATTCGTCAAG TGGGATGATGACTCAACTATTGTTACTCCAATTATTTTGAGGACTGACCCTCAGGGATTTTTCTTTTACTGGACAGATCAAAACAAGGTC TATCATTTGGCAAGTGTACGCTTACGTGATCTATGTCTAAAACTGGATGTTTCAAATGAGTTACGAAGGAAGATATGGACGTGTTTTGAA TTCACTTTAGTTCACTGTCCTGATCTAATGAAAGACAGGCATTTGGATCAGCTCCTCCTTTGTGCCTTTTATATCATGGCAAAGGTAACA AAAGAAGAAAGAACTTTTCAAGAAATTATGAAAAGTTATAGGAATCAGCCCCAAGCTAATAGTCACGTATATAGAAGTGTTCTGCTGAAA AGTATTCCAAGAGAAGTTGTGGCATATAATAAAAATATAAATGATGACTTTGAAATGATAGATTGTGACTTAGAAGATGCTACAAAAACA CCTGACTGTTCCAGTGGACCAGTGAAAGAGGAAAGAGGTGATCTTATAAAATTTTACAATACAATATATGTAGGAAGAGTGAAGTCATTT GCACTGAAATACGACTTGGCGAATCAGGACCATATGATGGATGCTCCACCACTCTCTCCTTTTCCACATATTAAACAACAGCCAGGCTCA CCACGCCGCATTTCCCAGCAGCACTCCATTTATATTTCCCCGCACAAGAATGGGTCAGGCCTTACACCAAGAAGCGCTCTGCTGTACAAG >In-frame_PLCB1_ENST00000378637_chr20_8131018_+_RBL1_ENST00000373664_chr20_35651229_-_1002nt ATGGCCGGGGCTCAACCCGGAGTGCACGCCTTGCAACTCAAGCCCGTGTGCGTGTCCGACAGCCTCAAGAAGGGCACCAAATTCGTCAAG TGGGATGATGACTCAACTATTGTTACTCCAATTATTTTGAGGACTGACCCTCAGGGATTTTTCTTTTACTGGACAGATCAAAACAAGGTC TATCATTTGGCAAGTGTACGCTTACGTGATCTATGTCTAAAACTGGATGTTTCAAATGAGTTACGAAGGAAGATATGGACGTGTTTTGAA TTCACTTTAGTTCACTGTCCTGATCTAATGAAAGACAGGCATTTGGATCAGCTCCTCCTTTGTGCCTTTTATATCATGGCAAAGGTAACA AAAGAAGAAAGAACTTTTCAAGAAATTATGAAAAGTTATAGGAATCAGCCCCAAGCTAATAGTCACGTATATAGAAGTGTTCTGCTGAAA AGTATTCCAAGAGAAGTTGTGGCATATAATAAAAATATAAATGATGACTTTGAAATGATAGATTGTGACTTAGAAGATGCTACAAAAACA CCTGACTGTTCCAGTGGACCAGTGAAAGAGGAAAGAGGTGATCTTATAAAATTTTACAATACAATATATGTAGGAAGAGTGAAGTCATTT GCACTGAAATACGACTTGGCGAATCAGGACCATATGATGGATGCTCCACCACTCTCTCCTTTTCCACATATTAAACAACAGCCAGGCTCA CCACGCCGCATTTCCCAGCAGCACTCCATTTATATTTCCCCGCACAAGAATGGGTCAGGCCTTACACCAAGAAGCGCTCTGCTGTACAAG TTCAATGGCAGCCCTTCTAAGAGTTTGAAAGATATCAACAACATGATAAGGCAAGGTGAGCAGAGAACCAAGAAGCGAGTAATAGCCATC GATAGTGATGCAGAATCCCCTGCCAAACGCGTCTGTCAAGAAAATGATGACGTTTTACTGAAACGACTACAGGATGTTGTCAGTGAAAGA >In-frame_PLCB1_ENST00000378637_chr20_8131018_+_RBL1_ENST00000344359_chr20_35651229_-_840nt ATGGCCGGGGCTCAACCCGGAGTGCACGCCTTGCAACTCAAGCCCGTGTGCGTGTCCGACAGCCTCAAGAAGGGCACCAAATTCGTCAAG TGGGATGATGACTCAACTATTGTTACTCCAATTATTTTGAGGACTGACCCTCAGGGATTTTTCTTTTACTGGACAGATCAAAACAAGGTC TATCATTTGGCAAGTGTACGCTTACGTGATCTATGTCTAAAACTGGATGTTTCAAATGAGTTACGAAGGAAGATATGGACGTGTTTTGAA TTCACTTTAGTTCACTGTCCTGATCTAATGAAAGACAGGCATTTGGATCAGCTCCTCCTTTGTGCCTTTTATATCATGGCAAAGGTAACA AAAGAAGAAAGAACTTTTCAAGAAATTATGAAAAGTTATAGGAATCAGCCCCAAGCTAATAGTCACGTATATAGAAGTGTTCTGCTGAAA AGTATTCCAAGAGAAGTTGTGGCATATAATAAAAATATAAATGATGACTTTGAAATGATAGATTGTGACTTAGAAGATGCTACAAAAACA CCTGACTGTTCCAGTGGACCAGTGAAAGAGGAAAGAGGTGATCTTATAAAATTTTACAATACAATATATGTAGGAAGAGTGAAGTCATTT GCACTGAAATACGACTTGGCGAATCAGGACCATATGATGGATGCTCCACCACTCTCTCCTTTTCCACATATTAAACAACAGCCAGGCTCA CCACGCCGCATTTCCCAGCAGCACTCCATTTATATTTCCCCGCACAAGAATGGGTCAGGCCTTACACCAAGAAGCGCTCTGCTGTACAAG |
| * Fusion transcript sequences (Full-length transcript). |
| >In-frame_PLCB1_ENST00000378641_chr20_8131018_+_RBL1_ENST00000373664_chr20_35651229_-_3887nt CAGCGAGCGAGGGTGGCGGGGAAGGGGGGCGGGGGGGAGGAGGAGGGAGGAGGGAAAAGAGCGGTTAGGGGGGGCGCCGGGCGTGTGTCA CTCGCTCTCTCCCTCTGTGTATAGAGGATGTGCTGAATGGTGCGCTTTGAGGCGGCGGCGGCGGAGGAGCAGAATCCGCCGCGACTGGCA GCCTCGGCTGACCGGCTCGGCTTCTCTTCGCCTTCCGAGGCTCCTCATCCACCGCGGGCTCCAGACCTCGCGTCCCGCCCGGGGCATGGC CGGGCGCTGCGCCCCCGCGCGCTCTGCCTGCTGAGCGGCGCCGGAGGGAGGTGCGGAGGCCGGGAGGCCGGGGAGGCCGGCGGGGAGCAG AGTCGAGCGCCTCCGGAGCAGAGAAAGGAGCCCGCGCCCCGCGCCCCGCGCCCCGCGCACGGTCCCCAGTCCCTGCCGCGCTCGCCCGGG CCGCCCGGAGCCCAGATGAGCCCAGATGGCCGGGGCTCAACCCGGAGTGCACGCCTTGCAACTCAAGCCCGTGTGCGTGTCCGACAGCCT CAAGAAGGGCACCAAATTCGTCAAGTGGGATGATGACTCAACTATTGTTACTCCAATTATTTTGAGGACTGACCCTCAGGGATTTTTCTT TTACTGGACAGATCAAAACAAGGTCTATCATTTGGCAAGTGTACGCTTACGTGATCTATGTCTAAAACTGGATGTTTCAAATGAGTTACG AAGGAAGATATGGACGTGTTTTGAATTCACTTTAGTTCACTGTCCTGATCTAATGAAAGACAGGCATTTGGATCAGCTCCTCCTTTGTGC CTTTTATATCATGGCAAAGGTAACAAAAGAAGAAAGAACTTTTCAAGAAATTATGAAAAGTTATAGGAATCAGCCCCAAGCTAATAGTCA CGTATATAGAAGTGTTCTGCTGAAAAGTATTCCAAGAGAAGTTGTGGCATATAATAAAAATATAAATGATGACTTTGAAATGATAGATTG TGACTTAGAAGATGCTACAAAAACACCTGACTGTTCCAGTGGACCAGTGAAAGAGGAAAGAGGTGATCTTATAAAATTTTACAATACAAT ATATGTAGGAAGAGTGAAGTCATTTGCACTGAAATACGACTTGGCGAATCAGGACCATATGATGGATGCTCCACCACTCTCTCCTTTTCC ACATATTAAACAACAGCCAGGCTCACCACGCCGCATTTCCCAGCAGCACTCCATTTATATTTCCCCGCACAAGAATGGGTCAGGCCTTAC ACCAAGAAGCGCTCTGCTGTACAAGTTCAATGGCAGCCCTTCTAAGAGTTTGAAAGATATCAACAACATGATAAGGCAAGGTGAGCAGAG AACCAAGAAGCGAGTAATAGCCATCGATAGTGATGCAGAATCCCCTGCCAAACGCGTCTGTCAAGAAAATGATGACGTTTTACTGAAACG ACTACAGGATGTTGTCAGTGAAAGAGCAAATCATTAATGTTGTTCTTGTTTCTATGATAAAAGCACTTTCAGATTGTTCTGCAGAAAGTT GGAGCTCTGTCCTTCAAACCTTTTAGCCCTATAGATGATAAATATCACTGGGTTATAAGAAAAAATTGCACAAAAATTATGTGCTTTTTA AAATATTTATCCAAAATGTAGTTGACAGAGATGTATTTTGAGTTGGATTGGAAAGGAATATTTTAAGTGCCTTTTAAAAATACTAATAGT CCGGCCAGGCGCTGTGGCTCACGCCTGTAATCCCAGGACTTTGGGAGGCCAAGGCGGGCAGATCACCGGAGGTCAGGAGTTCGAGACCAG CCTGACCAACATGGAGAAACCCCATCTCTACTAAAAATACAAAATTAGCCGGGTGTGGTGGCGCATGCCTGTAATCCCAGCTACTTGGGA GGCTGAGGCAGAATTGCTTGAACCCAGGAAGCGGAGGTTGTGGTGAGCCAAGGTTGCGCCACTGCACTCCAGCCTGGGCAACAAGAGTAA AACTCCATCTCAAAAAATATATATATATATATAAATAGGGAATTTTTTTTAATGTTTGCTCCTTGAGTTTTCAAGATGAAATAAGGAGAA ACCCCATAACTTTTTAGCTCTCTTTTAAAAATAAATGTCTCCTTCTGTGTTCTGTAATATGAGGATAAATAATCTACTTTTGATAGCATG CTTTGAGATATTTGTATTCTTAATTTAATATTGAAGGAAGGGGTTGGTTCCCATAGTACCTGGCCAGAGGGTTATATACCATCCTGTCTC TGGCCCACTGTGGTAATTCCACATCCAGGTACCACCGCCATTCAGAGTTGTCTCACCCCTTCTCGTGCCTTTTCTCTCCTTGAGCTTTAT AAACAGATTTGTACCTGAGCCCCAGTGCTACACTCATCCTTGCTTTCCAGCCCTAAGCCATCTCAGCCTGATGTCACAACCCAATAAATG GGGCACTTTCTTCTTTTGTAAACTATTATCATTTTGGTTTCTGTGACATTAACTTAATTATATATGATCGTATTAACTCATGTAGTTCTC AAAATAGGCAGCTGCTTCTGAAGCCAGTAAAATAAAATTCAGTTAGTTATTAAAAACTAAATTCCTATTAGTAAGGTAACACCATGATTA TGTGTGATATACTGTTTTTGAGATCATAGTTATCAGTCATTCTCAATATCTAATTGAGTCCCTAAGAATATTTTAAACCTTTTAAAAATC ACATAAATATCATCTCATGCCTCATAATTCTAATATATTTAATACATCAGTAAAATAGCTGCTTATTACTTCCCACACTTTGTTCTCAGT ATTGTTAGTGCATCATGAGTTTCCTGCTAGTGTTTGACCACTGGGTACTCCTGAAGATGTTTTTTAGTACTAGGGATGCTTTTCAGTATT AGGGATGCTTTTTTCAGTACTAGGGATGTACTAGGGAGTACTGAGTACTCCTGAAGATGTTTTTCAGTACTAGGGATGCTTTTTTCAGTG TTAGGGATGCTTTTCAGTACTAGGGATGCTTTTTTCAGTGCTAGGGATGCTTTTCAGTACTAGGGATGCTTTCCAAAATATCACCTCTTT AACGTTTACTTTTTCTAGTGTGTGTCTGGAATCCAAAGGACATGAATAAGCCACTCATAATTAATTTTGAGAAGTTTTATCAAATGTTTA TGTTTCTAACTGCAAACCTTAATTTTGGAAAGGCACAATGTTTAACTCACCTATGTTTAACCATGGCTAATTTAAAATAGTCTAAGATTT GGCCGTCACTAATTAGTATTCTCAAGAATTTCATTTTTCAATTTTAAGAAGAAAAGGGATTTTGGTCACATTTTGCTTGTAAATGAAAAT TACATCCTCATTCTTTGTGTAGTATCTACACATTGTTATAAGCCAAAAAACAAAGTCTGTCTGGAATCTTTGTACATATTTGTATGTTGC TATAATTGTTATTTTTATCTTCATTATTGTGCAAAATATAAATGAGCATTTGTACATTGACTGTATAAGAAACCATGGGCCAGGTCCTGT GGCTCATGCCTATAATCCCAACACTTTGGGAGGCTGAGGCAGGAGGATTGCTTCAGTCCAGGAGTTCAAGACTAACCTGGGCAACATAGC CCTCATCTCTACAAAAAATAAAAAAATTAGTTGGGTGTGATGGCATGTGCCTGTAGTCCCAGCTACTCAGGAGACTGACATGAGAGGATC ACTTGAGACTGGGAGATTCTGAGGCTGCAGTGAGCTGTGATTGCACCACTACACTCCATCCTAGGTGAGAGGGCAAGACCCTTTCTCAGA AAAGGAAAAAAAGAAATTCTGGACATGTTTTTATCAGTTTTCAGGACTTGGTATCAATGTACATAGAATGGCTAATAAAAATTGGAATTG >In-frame_PLCB1_ENST00000378641_chr20_8131018_+_RBL1_ENST00000344359_chr20_35651229_-_1434nt CAGCGAGCGAGGGTGGCGGGGAAGGGGGGCGGGGGGGAGGAGGAGGGAGGAGGGAAAAGAGCGGTTAGGGGGGGCGCCGGGCGTGTGTCA CTCGCTCTCTCCCTCTGTGTATAGAGGATGTGCTGAATGGTGCGCTTTGAGGCGGCGGCGGCGGAGGAGCAGAATCCGCCGCGACTGGCA GCCTCGGCTGACCGGCTCGGCTTCTCTTCGCCTTCCGAGGCTCCTCATCCACCGCGGGCTCCAGACCTCGCGTCCCGCCCGGGGCATGGC CGGGCGCTGCGCCCCCGCGCGCTCTGCCTGCTGAGCGGCGCCGGAGGGAGGTGCGGAGGCCGGGAGGCCGGGGAGGCCGGCGGGGAGCAG AGTCGAGCGCCTCCGGAGCAGAGAAAGGAGCCCGCGCCCCGCGCCCCGCGCCCCGCGCACGGTCCCCAGTCCCTGCCGCGCTCGCCCGGG CCGCCCGGAGCCCAGATGAGCCCAGATGGCCGGGGCTCAACCCGGAGTGCACGCCTTGCAACTCAAGCCCGTGTGCGTGTCCGACAGCCT CAAGAAGGGCACCAAATTCGTCAAGTGGGATGATGACTCAACTATTGTTACTCCAATTATTTTGAGGACTGACCCTCAGGGATTTTTCTT TTACTGGACAGATCAAAACAAGGTCTATCATTTGGCAAGTGTACGCTTACGTGATCTATGTCTAAAACTGGATGTTTCAAATGAGTTACG AAGGAAGATATGGACGTGTTTTGAATTCACTTTAGTTCACTGTCCTGATCTAATGAAAGACAGGCATTTGGATCAGCTCCTCCTTTGTGC CTTTTATATCATGGCAAAGGTAACAAAAGAAGAAAGAACTTTTCAAGAAATTATGAAAAGTTATAGGAATCAGCCCCAAGCTAATAGTCA CGTATATAGAAGTGTTCTGCTGAAAAGTATTCCAAGAGAAGTTGTGGCATATAATAAAAATATAAATGATGACTTTGAAATGATAGATTG TGACTTAGAAGATGCTACAAAAACACCTGACTGTTCCAGTGGACCAGTGAAAGAGGAAAGAGGTGATCTTATAAAATTTTACAATACAAT ATATGTAGGAAGAGTGAAGTCATTTGCACTGAAATACGACTTGGCGAATCAGGACCATATGATGGATGCTCCACCACTCTCTCCTTTTCC ACATATTAAACAACAGCCAGGCTCACCACGCCGCATTTCCCAGCAGCACTCCATTTATATTTCCCCGCACAAGAATGGGTCAGGCCTTAC ACCAAGAAGCGCTCTGCTGTACAAGTTCAATGGCAGCCCTTCTAAGGTAAGGTGAATAGGCTAAAAGTTGGATTTCAGATTAACAGTCAG >In-frame_PLCB1_ENST00000338037_chr20_8131018_+_RBL1_ENST00000373664_chr20_35651229_-_3439nt GGCCGCCCGGAGCCCAGATGAGCCCAGATGGCCGGGGCTCAACCCGGAGTGCACGCCTTGCAACTCAAGCCCGTGTGCGTGTCCGACAGC CTCAAGAAGGGCACCAAATTCGTCAAGTGGGATGATGACTCAACTATTGTTACTCCAATTATTTTGAGGACTGACCCTCAGGGATTTTTC TTTTACTGGACAGATCAAAACAAGGTCTATCATTTGGCAAGTGTACGCTTACGTGATCTATGTCTAAAACTGGATGTTTCAAATGAGTTA CGAAGGAAGATATGGACGTGTTTTGAATTCACTTTAGTTCACTGTCCTGATCTAATGAAAGACAGGCATTTGGATCAGCTCCTCCTTTGT GCCTTTTATATCATGGCAAAGGTAACAAAAGAAGAAAGAACTTTTCAAGAAATTATGAAAAGTTATAGGAATCAGCCCCAAGCTAATAGT CACGTATATAGAAGTGTTCTGCTGAAAAGTATTCCAAGAGAAGTTGTGGCATATAATAAAAATATAAATGATGACTTTGAAATGATAGAT TGTGACTTAGAAGATGCTACAAAAACACCTGACTGTTCCAGTGGACCAGTGAAAGAGGAAAGAGGTGATCTTATAAAATTTTACAATACA ATATATGTAGGAAGAGTGAAGTCATTTGCACTGAAATACGACTTGGCGAATCAGGACCATATGATGGATGCTCCACCACTCTCTCCTTTT CCACATATTAAACAACAGCCAGGCTCACCACGCCGCATTTCCCAGCAGCACTCCATTTATATTTCCCCGCACAAGAATGGGTCAGGCCTT ACACCAAGAAGCGCTCTGCTGTACAAGTTCAATGGCAGCCCTTCTAAGAGTTTGAAAGATATCAACAACATGATAAGGCAAGGTGAGCAG AGAACCAAGAAGCGAGTAATAGCCATCGATAGTGATGCAGAATCCCCTGCCAAACGCGTCTGTCAAGAAAATGATGACGTTTTACTGAAA CGACTACAGGATGTTGTCAGTGAAAGAGCAAATCATTAATGTTGTTCTTGTTTCTATGATAAAAGCACTTTCAGATTGTTCTGCAGAAAG TTGGAGCTCTGTCCTTCAAACCTTTTAGCCCTATAGATGATAAATATCACTGGGTTATAAGAAAAAATTGCACAAAAATTATGTGCTTTT TAAAATATTTATCCAAAATGTAGTTGACAGAGATGTATTTTGAGTTGGATTGGAAAGGAATATTTTAAGTGCCTTTTAAAAATACTAATA GTCCGGCCAGGCGCTGTGGCTCACGCCTGTAATCCCAGGACTTTGGGAGGCCAAGGCGGGCAGATCACCGGAGGTCAGGAGTTCGAGACC AGCCTGACCAACATGGAGAAACCCCATCTCTACTAAAAATACAAAATTAGCCGGGTGTGGTGGCGCATGCCTGTAATCCCAGCTACTTGG GAGGCTGAGGCAGAATTGCTTGAACCCAGGAAGCGGAGGTTGTGGTGAGCCAAGGTTGCGCCACTGCACTCCAGCCTGGGCAACAAGAGT AAAACTCCATCTCAAAAAATATATATATATATATAAATAGGGAATTTTTTTTAATGTTTGCTCCTTGAGTTTTCAAGATGAAATAAGGAG AAACCCCATAACTTTTTAGCTCTCTTTTAAAAATAAATGTCTCCTTCTGTGTTCTGTAATATGAGGATAAATAATCTACTTTTGATAGCA TGCTTTGAGATATTTGTATTCTTAATTTAATATTGAAGGAAGGGGTTGGTTCCCATAGTACCTGGCCAGAGGGTTATATACCATCCTGTC TCTGGCCCACTGTGGTAATTCCACATCCAGGTACCACCGCCATTCAGAGTTGTCTCACCCCTTCTCGTGCCTTTTCTCTCCTTGAGCTTT ATAAACAGATTTGTACCTGAGCCCCAGTGCTACACTCATCCTTGCTTTCCAGCCCTAAGCCATCTCAGCCTGATGTCACAACCCAATAAA TGGGGCACTTTCTTCTTTTGTAAACTATTATCATTTTGGTTTCTGTGACATTAACTTAATTATATATGATCGTATTAACTCATGTAGTTC TCAAAATAGGCAGCTGCTTCTGAAGCCAGTAAAATAAAATTCAGTTAGTTATTAAAAACTAAATTCCTATTAGTAAGGTAACACCATGAT TATGTGTGATATACTGTTTTTGAGATCATAGTTATCAGTCATTCTCAATATCTAATTGAGTCCCTAAGAATATTTTAAACCTTTTAAAAA TCACATAAATATCATCTCATGCCTCATAATTCTAATATATTTAATACATCAGTAAAATAGCTGCTTATTACTTCCCACACTTTGTTCTCA GTATTGTTAGTGCATCATGAGTTTCCTGCTAGTGTTTGACCACTGGGTACTCCTGAAGATGTTTTTTAGTACTAGGGATGCTTTTCAGTA TTAGGGATGCTTTTTTCAGTACTAGGGATGTACTAGGGAGTACTGAGTACTCCTGAAGATGTTTTTCAGTACTAGGGATGCTTTTTTCAG TGTTAGGGATGCTTTTCAGTACTAGGGATGCTTTTTTCAGTGCTAGGGATGCTTTTCAGTACTAGGGATGCTTTCCAAAATATCACCTCT TTAACGTTTACTTTTTCTAGTGTGTGTCTGGAATCCAAAGGACATGAATAAGCCACTCATAATTAATTTTGAGAAGTTTTATCAAATGTT TATGTTTCTAACTGCAAACCTTAATTTTGGAAAGGCACAATGTTTAACTCACCTATGTTTAACCATGGCTAATTTAAAATAGTCTAAGAT TTGGCCGTCACTAATTAGTATTCTCAAGAATTTCATTTTTCAATTTTAAGAAGAAAAGGGATTTTGGTCACATTTTGCTTGTAAATGAAA ATTACATCCTCATTCTTTGTGTAGTATCTACACATTGTTATAAGCCAAAAAACAAAGTCTGTCTGGAATCTTTGTACATATTTGTATGTT GCTATAATTGTTATTTTTATCTTCATTATTGTGCAAAATATAAATGAGCATTTGTACATTGACTGTATAAGAAACCATGGGCCAGGTCCT GTGGCTCATGCCTATAATCCCAACACTTTGGGAGGCTGAGGCAGGAGGATTGCTTCAGTCCAGGAGTTCAAGACTAACCTGGGCAACATA GCCCTCATCTCTACAAAAAATAAAAAAATTAGTTGGGTGTGATGGCATGTGCCTGTAGTCCCAGCTACTCAGGAGACTGACATGAGAGGA TCACTTGAGACTGGGAGATTCTGAGGCTGCAGTGAGCTGTGATTGCACCACTACACTCCATCCTAGGTGAGAGGGCAAGACCCTTTCTCA GAAAAGGAAAAAAAGAAATTCTGGACATGTTTTTATCAGTTTTCAGGACTTGGTATCAATGTACATAGAATGGCTAATAAAAATTGGAAT >In-frame_PLCB1_ENST00000338037_chr20_8131018_+_RBL1_ENST00000344359_chr20_35651229_-_986nt GGCCGCCCGGAGCCCAGATGAGCCCAGATGGCCGGGGCTCAACCCGGAGTGCACGCCTTGCAACTCAAGCCCGTGTGCGTGTCCGACAGC CTCAAGAAGGGCACCAAATTCGTCAAGTGGGATGATGACTCAACTATTGTTACTCCAATTATTTTGAGGACTGACCCTCAGGGATTTTTC TTTTACTGGACAGATCAAAACAAGGTCTATCATTTGGCAAGTGTACGCTTACGTGATCTATGTCTAAAACTGGATGTTTCAAATGAGTTA CGAAGGAAGATATGGACGTGTTTTGAATTCACTTTAGTTCACTGTCCTGATCTAATGAAAGACAGGCATTTGGATCAGCTCCTCCTTTGT GCCTTTTATATCATGGCAAAGGTAACAAAAGAAGAAAGAACTTTTCAAGAAATTATGAAAAGTTATAGGAATCAGCCCCAAGCTAATAGT CACGTATATAGAAGTGTTCTGCTGAAAAGTATTCCAAGAGAAGTTGTGGCATATAATAAAAATATAAATGATGACTTTGAAATGATAGAT TGTGACTTAGAAGATGCTACAAAAACACCTGACTGTTCCAGTGGACCAGTGAAAGAGGAAAGAGGTGATCTTATAAAATTTTACAATACA ATATATGTAGGAAGAGTGAAGTCATTTGCACTGAAATACGACTTGGCGAATCAGGACCATATGATGGATGCTCCACCACTCTCTCCTTTT CCACATATTAAACAACAGCCAGGCTCACCACGCCGCATTTCCCAGCAGCACTCCATTTATATTTCCCCGCACAAGAATGGGTCAGGCCTT ACACCAAGAAGCGCTCTGCTGTACAAGTTCAATGGCAGCCCTTCTAAGGTAAGGTGAATAGGCTAAAAGTTGGATTTCAGATTAACAGTC >In-frame_PLCB1_ENST00000378637_chr20_8131018_+_RBL1_ENST00000373664_chr20_35651229_-_3415nt CAGATGGCCGGGGCTCAACCCGGAGTGCACGCCTTGCAACTCAAGCCCGTGTGCGTGTCCGACAGCCTCAAGAAGGGCACCAAATTCGTC AAGTGGGATGATGACTCAACTATTGTTACTCCAATTATTTTGAGGACTGACCCTCAGGGATTTTTCTTTTACTGGACAGATCAAAACAAG GTCTATCATTTGGCAAGTGTACGCTTACGTGATCTATGTCTAAAACTGGATGTTTCAAATGAGTTACGAAGGAAGATATGGACGTGTTTT GAATTCACTTTAGTTCACTGTCCTGATCTAATGAAAGACAGGCATTTGGATCAGCTCCTCCTTTGTGCCTTTTATATCATGGCAAAGGTA ACAAAAGAAGAAAGAACTTTTCAAGAAATTATGAAAAGTTATAGGAATCAGCCCCAAGCTAATAGTCACGTATATAGAAGTGTTCTGCTG AAAAGTATTCCAAGAGAAGTTGTGGCATATAATAAAAATATAAATGATGACTTTGAAATGATAGATTGTGACTTAGAAGATGCTACAAAA ACACCTGACTGTTCCAGTGGACCAGTGAAAGAGGAAAGAGGTGATCTTATAAAATTTTACAATACAATATATGTAGGAAGAGTGAAGTCA TTTGCACTGAAATACGACTTGGCGAATCAGGACCATATGATGGATGCTCCACCACTCTCTCCTTTTCCACATATTAAACAACAGCCAGGC TCACCACGCCGCATTTCCCAGCAGCACTCCATTTATATTTCCCCGCACAAGAATGGGTCAGGCCTTACACCAAGAAGCGCTCTGCTGTAC AAGTTCAATGGCAGCCCTTCTAAGAGTTTGAAAGATATCAACAACATGATAAGGCAAGGTGAGCAGAGAACCAAGAAGCGAGTAATAGCC ATCGATAGTGATGCAGAATCCCCTGCCAAACGCGTCTGTCAAGAAAATGATGACGTTTTACTGAAACGACTACAGGATGTTGTCAGTGAA AGAGCAAATCATTAATGTTGTTCTTGTTTCTATGATAAAAGCACTTTCAGATTGTTCTGCAGAAAGTTGGAGCTCTGTCCTTCAAACCTT TTAGCCCTATAGATGATAAATATCACTGGGTTATAAGAAAAAATTGCACAAAAATTATGTGCTTTTTAAAATATTTATCCAAAATGTAGT TGACAGAGATGTATTTTGAGTTGGATTGGAAAGGAATATTTTAAGTGCCTTTTAAAAATACTAATAGTCCGGCCAGGCGCTGTGGCTCAC GCCTGTAATCCCAGGACTTTGGGAGGCCAAGGCGGGCAGATCACCGGAGGTCAGGAGTTCGAGACCAGCCTGACCAACATGGAGAAACCC CATCTCTACTAAAAATACAAAATTAGCCGGGTGTGGTGGCGCATGCCTGTAATCCCAGCTACTTGGGAGGCTGAGGCAGAATTGCTTGAA CCCAGGAAGCGGAGGTTGTGGTGAGCCAAGGTTGCGCCACTGCACTCCAGCCTGGGCAACAAGAGTAAAACTCCATCTCAAAAAATATAT ATATATATATAAATAGGGAATTTTTTTTAATGTTTGCTCCTTGAGTTTTCAAGATGAAATAAGGAGAAACCCCATAACTTTTTAGCTCTC TTTTAAAAATAAATGTCTCCTTCTGTGTTCTGTAATATGAGGATAAATAATCTACTTTTGATAGCATGCTTTGAGATATTTGTATTCTTA ATTTAATATTGAAGGAAGGGGTTGGTTCCCATAGTACCTGGCCAGAGGGTTATATACCATCCTGTCTCTGGCCCACTGTGGTAATTCCAC ATCCAGGTACCACCGCCATTCAGAGTTGTCTCACCCCTTCTCGTGCCTTTTCTCTCCTTGAGCTTTATAAACAGATTTGTACCTGAGCCC CAGTGCTACACTCATCCTTGCTTTCCAGCCCTAAGCCATCTCAGCCTGATGTCACAACCCAATAAATGGGGCACTTTCTTCTTTTGTAAA CTATTATCATTTTGGTTTCTGTGACATTAACTTAATTATATATGATCGTATTAACTCATGTAGTTCTCAAAATAGGCAGCTGCTTCTGAA GCCAGTAAAATAAAATTCAGTTAGTTATTAAAAACTAAATTCCTATTAGTAAGGTAACACCATGATTATGTGTGATATACTGTTTTTGAG ATCATAGTTATCAGTCATTCTCAATATCTAATTGAGTCCCTAAGAATATTTTAAACCTTTTAAAAATCACATAAATATCATCTCATGCCT CATAATTCTAATATATTTAATACATCAGTAAAATAGCTGCTTATTACTTCCCACACTTTGTTCTCAGTATTGTTAGTGCATCATGAGTTT CCTGCTAGTGTTTGACCACTGGGTACTCCTGAAGATGTTTTTTAGTACTAGGGATGCTTTTCAGTATTAGGGATGCTTTTTTCAGTACTA GGGATGTACTAGGGAGTACTGAGTACTCCTGAAGATGTTTTTCAGTACTAGGGATGCTTTTTTCAGTGTTAGGGATGCTTTTCAGTACTA GGGATGCTTTTTTCAGTGCTAGGGATGCTTTTCAGTACTAGGGATGCTTTCCAAAATATCACCTCTTTAACGTTTACTTTTTCTAGTGTG TGTCTGGAATCCAAAGGACATGAATAAGCCACTCATAATTAATTTTGAGAAGTTTTATCAAATGTTTATGTTTCTAACTGCAAACCTTAA TTTTGGAAAGGCACAATGTTTAACTCACCTATGTTTAACCATGGCTAATTTAAAATAGTCTAAGATTTGGCCGTCACTAATTAGTATTCT CAAGAATTTCATTTTTCAATTTTAAGAAGAAAAGGGATTTTGGTCACATTTTGCTTGTAAATGAAAATTACATCCTCATTCTTTGTGTAG TATCTACACATTGTTATAAGCCAAAAAACAAAGTCTGTCTGGAATCTTTGTACATATTTGTATGTTGCTATAATTGTTATTTTTATCTTC ATTATTGTGCAAAATATAAATGAGCATTTGTACATTGACTGTATAAGAAACCATGGGCCAGGTCCTGTGGCTCATGCCTATAATCCCAAC ACTTTGGGAGGCTGAGGCAGGAGGATTGCTTCAGTCCAGGAGTTCAAGACTAACCTGGGCAACATAGCCCTCATCTCTACAAAAAATAAA AAAATTAGTTGGGTGTGATGGCATGTGCCTGTAGTCCCAGCTACTCAGGAGACTGACATGAGAGGATCACTTGAGACTGGGAGATTCTGA GGCTGCAGTGAGCTGTGATTGCACCACTACACTCCATCCTAGGTGAGAGGGCAAGACCCTTTCTCAGAAAAGGAAAAAAAGAAATTCTGG >In-frame_PLCB1_ENST00000378637_chr20_8131018_+_RBL1_ENST00000344359_chr20_35651229_-_962nt CAGATGGCCGGGGCTCAACCCGGAGTGCACGCCTTGCAACTCAAGCCCGTGTGCGTGTCCGACAGCCTCAAGAAGGGCACCAAATTCGTC AAGTGGGATGATGACTCAACTATTGTTACTCCAATTATTTTGAGGACTGACCCTCAGGGATTTTTCTTTTACTGGACAGATCAAAACAAG GTCTATCATTTGGCAAGTGTACGCTTACGTGATCTATGTCTAAAACTGGATGTTTCAAATGAGTTACGAAGGAAGATATGGACGTGTTTT GAATTCACTTTAGTTCACTGTCCTGATCTAATGAAAGACAGGCATTTGGATCAGCTCCTCCTTTGTGCCTTTTATATCATGGCAAAGGTA ACAAAAGAAGAAAGAACTTTTCAAGAAATTATGAAAAGTTATAGGAATCAGCCCCAAGCTAATAGTCACGTATATAGAAGTGTTCTGCTG AAAAGTATTCCAAGAGAAGTTGTGGCATATAATAAAAATATAAATGATGACTTTGAAATGATAGATTGTGACTTAGAAGATGCTACAAAA ACACCTGACTGTTCCAGTGGACCAGTGAAAGAGGAAAGAGGTGATCTTATAAAATTTTACAATACAATATATGTAGGAAGAGTGAAGTCA TTTGCACTGAAATACGACTTGGCGAATCAGGACCATATGATGGATGCTCCACCACTCTCTCCTTTTCCACATATTAAACAACAGCCAGGC TCACCACGCCGCATTTCCCAGCAGCACTCCATTTATATTTCCCCGCACAAGAATGGGTCAGGCCTTACACCAAGAAGCGCTCTGCTGTAC AAGTTCAATGGCAGCCCTTCTAAGGTAAGGTGAATAGGCTAAAAGTTGGATTTCAGATTAACAGTCAGTAACTGTTAATCCTGCCTCTTT |
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FusionGenePPI for PLCB1_RBL1 |
| Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in . |
| Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160) |
| Hgene | Hgene's interactors | Tgene | Tgene's interactors |
| PLCB1 | TRPM7, SLC9A3R1, SPTBN1, KRIT1, PCF11, GNA11, GNAQ, PLCB1, CTBP1, CTBP2, TFCP2, CEP76, BTN2A1, PTGER3, GAN, DEF8 | RBL1 | RBBP8, BEGAIN, BRCA1, MYBL2, CDKN1C, SUV39H1, HDAC1, HDAC2, HDAC3, ARID4A, CCNE1, CDK2, E2F5, KDM5A, AATF, SMAD3, SMAD4, E2F4, SNW1, MCM7, CCNA2, E2F1, PPP2R3A, CREG1, CCNA1, TFDP1, TFDP2, RBBP9, TAF1, BRF1, PHB, USP4, MYC, EMD, RBL2, IRF3, MAPK6, E2F3, LIN37, LIN9, LIN54, SMARCA4, TOP1, E2F2, RINT1, ID2, DGKZ, CDK4, CDK6, SP1, GOLGA2, SNRPD3, AOX1, EPHA2, FN1, NR4A1, LAMB2, NUCB1, PLSCR1, MAGEA11, AR, DYRK1A, DYRK1B, TXNDC11, CTBP1, C3orf62, NTRK1, FOXK1, FOXO3, TSC22D2, KIAA0430, HELZ |
| - Retained PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
| - Lost PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
| - Retained PPIs, but lost function due to frame-shift fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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RelatedDrugs for PLCB1_RBL1 |
| Drugs targeting genes involved in this fusion gene. (DrugBank Version 5.1.0 2018-04-02) |
| Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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RelatedDiseases for PLCB1_RBL1 |
| Diseases associated with fusion partners. (DisGeNet 4.0) |
| Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
| Hgene | PLCB1 | C0005586 | Bipolar Disorder | 1 | PSYGENET |
| Hgene | PLCB1 | C0009375 | Colonic Neoplasms | 1 | CTD_human |
| Hgene | PLCB1 | C0030193 | Pain | 1 | CTD_human |
| Hgene | PLCB1 | C0036341 | Schizophrenia | 1 | CTD_human |
| Hgene | PLCB1 | C0041696 | Unipolar Depression | 1 | PSYGENET |
| Hgene | PLCB1 | C1269683 | Major Depressive Disorder | 1 | PSYGENET |
| Hgene | PLCB1 | C3463824 | MYELODYSPLASTIC SYNDROME | 1 | CTD_human |
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