|
||||||
|
 | |
| |
| |
| |
| |
|
Fusion gene ID: 27447 |
FusionGeneSummary for PLA2R1_ITGB6 |
 Fusion gene summary |
| Fusion gene information | Fusion gene name: PLA2R1_ITGB6 | Fusion gene ID: 27447 | Hgene | Tgene | Gene symbol | PLA2R1 | ITGB6 | Gene ID | 22925 | 3694 |
| Gene name | phospholipase A2 receptor 1 | integrin subunit beta 6 | |
| Synonyms | CLEC13C|PLA2-R|PLA2G1R|PLA2IR|PLA2R | AI1H | |
| Cytomap | 2q24.2 | 2q24.2 | |
| Type of gene | protein-coding | protein-coding | |
| Description | secretory phospholipase A2 receptor180 kDa secretory phospholipase A2 receptorC-type lectin domain family 13 member CM-type receptorphospholipase A2 receptor 1, 180kDphospholipase A2 receptor 1, 180kDa | integrin beta-6integrin, beta 6 | |
| Modification date | 20180523 | 20180523 | |
| UniProtAcc | Q13018 | P18564 | |
| Ensembl transtripts involved in fusion gene | ENST00000283243, ENST00000392771, ENST00000460710, | ENST00000283249, ENST00000485635, ENST00000428609, ENST00000409967, ENST00000409872, | |
| Fusion gene scores | * DoF score | 2 X 2 X 2=8 | 4 X 3 X 4=48 |
| # samples | 2 | 4 | |
| ** MAII score | log2(2/8*10)=1.32192809488736 | log2(4/48*10)=-0.263034405833794 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | |
| Context | PubMed: PLA2R1 [Title/Abstract] AND ITGB6 [Title/Abstract] AND fusion [Title/Abstract] | ||
| Functional or gene categories assigned by FusionGDB annotation | Tumor suppressor gene involved fusion gene, in-frame but not retained their domain. | ||
| * DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
| Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Partner | Gene | GO ID | GO term | PubMed ID |
| Hgene | PLA2R1 | GO:0072593 | reactive oxygen species metabolic process | 19197340 |
| Tgene | ITGB6 | GO:0033627 | cell adhesion mediated by integrin | 17158881 |
| Fusion gene information from three resources (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| TCGA | RV | HNSC | TCGA-CR-7370-01A | PLA2R1 | chr2 | 160832579 | - | ITGB6 | chr2 | 160998582 | - |
| * LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
| Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| In-frame | ENST00000283243 | ENST00000283249 | PLA2R1 | chr2 | 160832579 | - | ITGB6 | chr2 | 160998582 | - |
| 5CDS-5UTR | ENST00000283243 | ENST00000485635 | PLA2R1 | chr2 | 160832579 | - | ITGB6 | chr2 | 160998582 | - |
| 5CDS-5UTR | ENST00000283243 | ENST00000428609 | PLA2R1 | chr2 | 160832579 | - | ITGB6 | chr2 | 160998582 | - |
| 5CDS-5UTR | ENST00000283243 | ENST00000409967 | PLA2R1 | chr2 | 160832579 | - | ITGB6 | chr2 | 160998582 | - |
| 5CDS-5UTR | ENST00000283243 | ENST00000409872 | PLA2R1 | chr2 | 160832579 | - | ITGB6 | chr2 | 160998582 | - |
| In-frame | ENST00000392771 | ENST00000283249 | PLA2R1 | chr2 | 160832579 | - | ITGB6 | chr2 | 160998582 | - |
| 5CDS-5UTR | ENST00000392771 | ENST00000485635 | PLA2R1 | chr2 | 160832579 | - | ITGB6 | chr2 | 160998582 | - |
| 5CDS-5UTR | ENST00000392771 | ENST00000428609 | PLA2R1 | chr2 | 160832579 | - | ITGB6 | chr2 | 160998582 | - |
| 5CDS-5UTR | ENST00000392771 | ENST00000409967 | PLA2R1 | chr2 | 160832579 | - | ITGB6 | chr2 | 160998582 | - |
| 5CDS-5UTR | ENST00000392771 | ENST00000409872 | PLA2R1 | chr2 | 160832579 | - | ITGB6 | chr2 | 160998582 | - |
| intron-3CDS | ENST00000460710 | ENST00000283249 | PLA2R1 | chr2 | 160832579 | - | ITGB6 | chr2 | 160998582 | - |
| intron-5UTR | ENST00000460710 | ENST00000485635 | PLA2R1 | chr2 | 160832579 | - | ITGB6 | chr2 | 160998582 | - |
| intron-5UTR | ENST00000460710 | ENST00000428609 | PLA2R1 | chr2 | 160832579 | - | ITGB6 | chr2 | 160998582 | - |
| intron-5UTR | ENST00000460710 | ENST00000409967 | PLA2R1 | chr2 | 160832579 | - | ITGB6 | chr2 | 160998582 | - |
| intron-5UTR | ENST00000460710 | ENST00000409872 | PLA2R1 | chr2 | 160832579 | - | ITGB6 | chr2 | 160998582 | - |
Top |
FusionProtFeatures for PLA2R1_ITGB6 |
| Main function of each fusion partner protein. (from UniProt) |
| Hgene | Tgene |
| PLA2R1 | ITGB6 |
| Receptor for secretory phospholipase A2 (sPLA2). Acts asa receptor for phosholipase sPLA2-IB/PLA2G1B but not sPLA2-IIA/PLA2G2A. Also able to bind to snake PA2-like toxins. Althoughits precise function remains unclear, binding of sPLA2 to itsreceptor participates in both positive and negative regulation ofsPLA2 functions as well as clearance of sPLA2. Binding of sPLA2-IB/PLA2G1B induces various effects depending on the cell type,such as activation of the mitogen-activated protein kinase (MAPK)cascade to induce cell proliferation, the production of lipidmediators, selective release of arachidonic acid in bone marrow-derived mast cells. In neutrophils, binding of sPLA2-IB/PLA2G1Bcan activate p38 MAPK to stimulate elastase release and celladhesion. May be involved in responses in proinflammatory cytokineproductions during endotoxic shock. Also has endocytic propertiesand rapidly internalizes sPLA2 ligands, which is particularlyimportant for the clearance of extracellular sPLA2s to protecttheir potent enzymatic activities. The soluble secretoryphospholipase A2 receptor form is circulating and acts as anegative regulator of sPLA2 functions by blocking the biologicalfunctions of sPLA2-IB/PLA2G1B. {ECO:0000269|PubMed:15611272,ECO:0000269|PubMed:7721806}. | Integrin alpha-V/beta-6 is a receptor for fibronectinand cytotactin. It recognizes the sequence R-G-D in its ligands.Internalisation of integrin alpha-V/beta-6 via clathrin-mediatedendocytosis promotes carcinoma cell invasion. ITGAV:ITGB6 acts asa receptor for fibrillin-1 (FBN1) and mediates R-G-D-dependentcell adhesion to FBN1 (PubMed:17158881).{ECO:0000269|PubMed:17158881, ECO:0000269|PubMed:17545607}. (Microbial infection) Integrin ITGAV:ITGB6 acts as areceptor for Coxsackievirus A9 and Coxsackievirus B1.{ECO:0000269|PubMed:15194773, ECO:0000269|PubMed:9426447}. (Microbial infection) Integrin ITGAV:ITGB6 acts as areceptor for Herpes simplex virus-1/HHV-1 (PubMed:24367260).{ECO:0000269|PubMed:24367260}. |
| Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at . * Minus value of BPloci means that the break pointn is located before the CDS. |
| - In-frame and retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
| Hgene | PLA2R1 | chr2:160832579 | chr2:160998582 | ENST00000283243 | - | 17 | 30 | 173_221 | 865 | 1464 | Domain | Fibronectin type-II |
| Hgene | PLA2R1 | chr2:160832579 | chr2:160998582 | ENST00000283243 | - | 17 | 30 | 238_355 | 865 | 1464 | Domain | C-type lectin 1 |
| Hgene | PLA2R1 | chr2:160832579 | chr2:160998582 | ENST00000283243 | - | 17 | 30 | 385_502 | 865 | 1464 | Domain | C-type lectin 2 |
| Hgene | PLA2R1 | chr2:160832579 | chr2:160998582 | ENST00000283243 | - | 17 | 30 | 38_161 | 865 | 1464 | Domain | Ricin B-type lectin |
| Hgene | PLA2R1 | chr2:160832579 | chr2:160998582 | ENST00000283243 | - | 17 | 30 | 522_643 | 865 | 1464 | Domain | C-type lectin 3 |
| Hgene | PLA2R1 | chr2:160832579 | chr2:160998582 | ENST00000283243 | - | 17 | 30 | 673_797 | 865 | 1464 | Domain | C-type lectin 4 |
| Hgene | PLA2R1 | chr2:160832579 | chr2:160998582 | ENST00000392771 | - | 17 | 27 | 173_221 | 865 | 1325 | Domain | Fibronectin type-II |
| Hgene | PLA2R1 | chr2:160832579 | chr2:160998582 | ENST00000392771 | - | 17 | 27 | 238_355 | 865 | 1325 | Domain | C-type lectin 1 |
| Hgene | PLA2R1 | chr2:160832579 | chr2:160998582 | ENST00000392771 | - | 17 | 27 | 385_502 | 865 | 1325 | Domain | C-type lectin 2 |
| Hgene | PLA2R1 | chr2:160832579 | chr2:160998582 | ENST00000392771 | - | 17 | 27 | 38_161 | 865 | 1325 | Domain | Ricin B-type lectin |
| Hgene | PLA2R1 | chr2:160832579 | chr2:160998582 | ENST00000392771 | - | 17 | 27 | 522_643 | 865 | 1325 | Domain | C-type lectin 3 |
| Hgene | PLA2R1 | chr2:160832579 | chr2:160998582 | ENST00000392771 | - | 17 | 27 | 673_797 | 865 | 1325 | Domain | C-type lectin 4 |
| Tgene | >ITGB6 | chr2:160832579 | chr2:160998582 | ENST00000283249 | - | 6 | 15 | 456_619 | 339 | 789 | Region | Note=Cysteine-rich tandem repeats |
| Tgene | >ITGB6 | chr2:160832579 | chr2:160998582 | ENST00000409872 | - | 7 | 16 | 456_619 | 339 | 789 | Region | Note=Cysteine-rich tandem repeats |
| Tgene | >ITGB6 | chr2:160832579 | chr2:160998582 | ENST00000283249 | - | 6 | 15 | 456_501 | 339 | 789 | Repeat | Note=I |
| Tgene | >ITGB6 | chr2:160832579 | chr2:160998582 | ENST00000283249 | - | 6 | 15 | 502_543 | 339 | 789 | Repeat | Note=II |
| Tgene | >ITGB6 | chr2:160832579 | chr2:160998582 | ENST00000283249 | - | 6 | 15 | 544_582 | 339 | 789 | Repeat | Note=III |
| Tgene | >ITGB6 | chr2:160832579 | chr2:160998582 | ENST00000283249 | - | 6 | 15 | 583_619 | 339 | 789 | Repeat | Note=IV |
| Tgene | >ITGB6 | chr2:160832579 | chr2:160998582 | ENST00000409872 | - | 7 | 16 | 456_501 | 339 | 789 | Repeat | Note=I |
| Tgene | >ITGB6 | chr2:160832579 | chr2:160998582 | ENST00000409872 | - | 7 | 16 | 502_543 | 339 | 789 | Repeat | Note=II |
| Tgene | >ITGB6 | chr2:160832579 | chr2:160998582 | ENST00000409872 | - | 7 | 16 | 544_582 | 339 | 789 | Repeat | Note=III |
| Tgene | >ITGB6 | chr2:160832579 | chr2:160998582 | ENST00000409872 | - | 7 | 16 | 583_619 | 339 | 789 | Repeat | Note=IV |
| Tgene | >ITGB6 | chr2:160832579 | chr2:160998582 | ENST00000283249 | - | 6 | 15 | 731_788 | 339 | 789 | Topological domain | Cytoplasmic |
| Tgene | >ITGB6 | chr2:160832579 | chr2:160998582 | ENST00000409872 | - | 7 | 16 | 731_788 | 339 | 789 | Topological domain | Cytoplasmic |
| Tgene | >ITGB6 | chr2:160832579 | chr2:160998582 | ENST00000283249 | - | 6 | 15 | 710_730 | 339 | 789 | Transmembrane | Helical |
| Tgene | >ITGB6 | chr2:160832579 | chr2:160998582 | ENST00000409872 | - | 7 | 16 | 710_730 | 339 | 789 | Transmembrane | Helical |
| - In-frame and not-retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
| Hgene | >PLA2R1 | chr2:160832579 | chr2:160998582 | ENST00000283243 | - | 17 | 30 | 1121_1232 | 865 | 1464 | Domain | C-type lectin 7 |
| Hgene | >PLA2R1 | chr2:160832579 | chr2:160998582 | ENST00000283243 | - | 17 | 30 | 1257_1378 | 865 | 1464 | Domain | C-type lectin 8 |
| Hgene | >PLA2R1 | chr2:160832579 | chr2:160998582 | ENST00000283243 | - | 17 | 30 | 819_938 | 865 | 1464 | Domain | C-type lectin 5 |
| Hgene | >PLA2R1 | chr2:160832579 | chr2:160998582 | ENST00000283243 | - | 17 | 30 | 965_1096 | 865 | 1464 | Domain | C-type lectin 6 |
| Hgene | >PLA2R1 | chr2:160832579 | chr2:160998582 | ENST00000392771 | - | 17 | 27 | 1121_1232 | 865 | 1325 | Domain | C-type lectin 7 |
| Hgene | >PLA2R1 | chr2:160832579 | chr2:160998582 | ENST00000392771 | - | 17 | 27 | 1257_1378 | 865 | 1325 | Domain | C-type lectin 8 |
| Hgene | >PLA2R1 | chr2:160832579 | chr2:160998582 | ENST00000392771 | - | 17 | 27 | 819_938 | 865 | 1325 | Domain | C-type lectin 5 |
| Hgene | >PLA2R1 | chr2:160832579 | chr2:160998582 | ENST00000392771 | - | 17 | 27 | 965_1096 | 865 | 1325 | Domain | C-type lectin 6 |
| Hgene | >PLA2R1 | chr2:160832579 | chr2:160998582 | ENST00000283243 | - | 17 | 30 | 1436_1442 | 865 | 1464 | Motif | Note=Endocytosis signal |
| Hgene | >PLA2R1 | chr2:160832579 | chr2:160998582 | ENST00000392771 | - | 17 | 27 | 1436_1442 | 865 | 1325 | Motif | Note=Endocytosis signal |
| Hgene | >PLA2R1 | chr2:160832579 | chr2:160998582 | ENST00000283243 | - | 17 | 30 | 1419_1463 | 865 | 1464 | Topological domain | Cytoplasmic |
| Hgene | >PLA2R1 | chr2:160832579 | chr2:160998582 | ENST00000283243 | - | 17 | 30 | 21_1397 | 865 | 1464 | Topological domain | Extracellular |
| Hgene | >PLA2R1 | chr2:160832579 | chr2:160998582 | ENST00000392771 | - | 17 | 27 | 1419_1463 | 865 | 1325 | Topological domain | Cytoplasmic |
| Hgene | >PLA2R1 | chr2:160832579 | chr2:160998582 | ENST00000392771 | - | 17 | 27 | 21_1397 | 865 | 1325 | Topological domain | Extracellular |
| Hgene | >PLA2R1 | chr2:160832579 | chr2:160998582 | ENST00000283243 | - | 17 | 30 | 1398_1418 | 865 | 1464 | Transmembrane | Helical |
| Hgene | >PLA2R1 | chr2:160832579 | chr2:160998582 | ENST00000392771 | - | 17 | 27 | 1398_1418 | 865 | 1325 | Transmembrane | Helical |
| Tgene | ITGB6 | chr2:160832579 | chr2:160998582 | ENST00000283249 | - | 6 | 15 | 131_371 | 339 | 789 | Domain | Note=VWFA |
| Tgene | ITGB6 | chr2:160832579 | chr2:160998582 | ENST00000409872 | - | 7 | 16 | 131_371 | 339 | 789 | Domain | Note=VWFA |
| Tgene | ITGB6 | chr2:160832579 | chr2:160998582 | ENST00000283249 | - | 6 | 15 | 22_709 | 339 | 789 | Topological domain | Extracellular |
| Tgene | ITGB6 | chr2:160832579 | chr2:160998582 | ENST00000409872 | - | 7 | 16 | 22_709 | 339 | 789 | Topological domain | Extracellular |
Top |
FusionGeneSequence for PLA2R1_ITGB6 |
| For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. (nt: nucleotides, aa: amino acids) |
| * Fusion amino acid sequences. |
| >In-frame_PLA2R1_ENST00000283243_chr2_160832579_-_ITGB6_ENST00000283249_chr2_160998582_-_1315aa MLLSPSLLLLLLLGAPRGCAEGVAAALTPERLLEWQDKGIFVIQSESLKKCIQAGKSVLTLENCKQANKHMLWKWVSNHGLFNIGGSGCL GLNFSAPEQPLSLYECDSTLVSLRWRCNRKMITGPLQYSVQVAHDNTVVASRKYIHKWISYGSGGGDICEYLHKDLHTIKGNTHGMPCMF PFQYNHQWHHECTREGREDDLLWCATTSRYERDEKWGFCPDPTSAEVGCDTIWEKDLNSHICYQFNLLSSLSWSEAHSSCQMQGGTLLSI TDETEENFIREHMSSKTVEVWMGLNQLDEHAGWQWSDGTPLNYLNWSPEVNFEPFVEDHCGTFSSFMPSAWRSRDCESTLPYICKKYLNH IDHEIVEKDAWKYYATHCEPGWNPYNRNCYKLQKEEKTWHEALRSCQADNSALIDITSLAEVEFLVTLLGDENASETWIGLSSNKIPVSF EWSNDSSVIFTNWHTLEPHIFPNRSQLCVSAEQSEGHWKVKNCEERLFYICKKAGHVLSDAESGCQEGWERHGGFCYKIDTVLRSFDQAS SGYYCPPALVTITNRFEQAFITSLISSVVKMKDSYFWIALQDQNDTGEYTWKPVGQKPEPVQYTHWNTHQPRYSGGCVAMRGRHPLGRWE VKHCRHFKAMSLCKQPVENQEKAEYEERWPFHPCYLDWESEPGLASCFKVFHSEKVLMKRTWREAEAFCEEFGAHLASFAHIEEENFVNE LLHSKFNWTEERQFWIGFNKRNPLNAGSWEWSDRTPVVSSFLDNTYFGEDARNCAVYKANKTLLPLHCGSKREWICKIPRDVKPKIPFWY QYDVPWLFYQDAEYLFHTFASEWLNFEFVCSWLHSDLLTIHSAHEQEFIHSKIKANYAKLIPGATVGLLQKDSGNILQLIISAYEELRSE VELEVLGDTEGLNLSFTAICNNGTLFQHQKKCSHMKVGDTASFSVTVNIPHCERRSRHIIIKPVGLGDALELLVSPECNCDCQKEVEVNS SKCHHGNGSFQCGVCACHPGHMGPRCECGEDMLSTDSCKEAPDHPSCSGRGDCYCGQCICHLSPYGNIYGPYCQCDNFSCVRHKGLLCGG NGDCDCGECVCRSGWTGEYCNCTTSTDSCVSEDGVLCSGRGDCVCGKCVCTNPGASGPTCERCPTCGDPCNSKRSCIECHLSAAGQAREE CVDKCKLAGATISEEEDFSKDGSVSCSLQGENECLITFLITTDNEGKTIIHSINEKDCPKPPNIPMIMLGVSLAILLIGVVLLCIWKLLV >In-frame_PLA2R1_ENST00000392771_chr2_160832579_-_ITGB6_ENST00000283249_chr2_160998582_-_1315aa MLLSPSLLLLLLLGAPRGCAEGVAAALTPERLLEWQDKGIFVIQSESLKKCIQAGKSVLTLENCKQANKHMLWKWVSNHGLFNIGGSGCL GLNFSAPEQPLSLYECDSTLVSLRWRCNRKMITGPLQYSVQVAHDNTVVASRKYIHKWISYGSGGGDICEYLHKDLHTIKGNTHGMPCMF PFQYNHQWHHECTREGREDDLLWCATTSRYERDEKWGFCPDPTSAEVGCDTIWEKDLNSHICYQFNLLSSLSWSEAHSSCQMQGGTLLSI TDETEENFIREHMSSKTVEVWMGLNQLDEHAGWQWSDGTPLNYLNWSPEVNFEPFVEDHCGTFSSFMPSAWRSRDCESTLPYICKKYLNH IDHEIVEKDAWKYYATHCEPGWNPYNRNCYKLQKEEKTWHEALRSCQADNSALIDITSLAEVEFLVTLLGDENASETWIGLSSNKIPVSF EWSNDSSVIFTNWHTLEPHIFPNRSQLCVSAEQSEGHWKVKNCEERLFYICKKAGHVLSDAESGCQEGWERHGGFCYKIDTVLRSFDQAS SGYYCPPALVTITNRFEQAFITSLISSVVKMKDSYFWIALQDQNDTGEYTWKPVGQKPEPVQYTHWNTHQPRYSGGCVAMRGRHPLGRWE VKHCRHFKAMSLCKQPVENQEKAEYEERWPFHPCYLDWESEPGLASCFKVFHSEKVLMKRTWREAEAFCEEFGAHLASFAHIEEENFVNE LLHSKFNWTEERQFWIGFNKRNPLNAGSWEWSDRTPVVSSFLDNTYFGEDARNCAVYKANKTLLPLHCGSKREWICKIPRDVKPKIPFWY QYDVPWLFYQDAEYLFHTFASEWLNFEFVCSWLHSDLLTIHSAHEQEFIHSKIKANYAKLIPGATVGLLQKDSGNILQLIISAYEELRSE VELEVLGDTEGLNLSFTAICNNGTLFQHQKKCSHMKVGDTASFSVTVNIPHCERRSRHIIIKPVGLGDALELLVSPECNCDCQKEVEVNS SKCHHGNGSFQCGVCACHPGHMGPRCECGEDMLSTDSCKEAPDHPSCSGRGDCYCGQCICHLSPYGNIYGPYCQCDNFSCVRHKGLLCGG NGDCDCGECVCRSGWTGEYCNCTTSTDSCVSEDGVLCSGRGDCVCGKCVCTNPGASGPTCERCPTCGDPCNSKRSCIECHLSAAGQAREE CVDKCKLAGATISEEEDFSKDGSVSCSLQGENECLITFLITTDNEGKTIIHSINEKDCPKPPNIPMIMLGVSLAILLIGVVLLCIWKLLV |
| * Fusion transcript sequences (only coding sequence (CDS) region). |
| >In-frame_PLA2R1_ENST00000283243_chr2_160832579_-_ITGB6_ENST00000283249_chr2_160998582_-_3945nt ATGCTGCTGTCGCCGTCGCTGCTGCTGCTGCTGCTGCTGGGGGCGCCGCGGGGCTGCGCCGAGGGTGTGGCGGCGGCGCTTACCCCCGAG CGGCTCCTGGAGTGGCAGGATAAAGGAATATTTGTTATCCAAAGTGAGAGTCTCAAGAAATGCATTCAAGCAGGTAAATCGGTTCTGACC CTGGAGAACTGCAAGCAAGCAAACAAGCACATGCTGTGGAAATGGGTTTCAAACCATGGCCTCTTTAACATAGGAGGCAGTGGTTGCCTG GGCCTGAATTTCTCCGCCCCAGAGCAGCCATTAAGCTTATATGAATGTGACTCCACCCTCGTTTCCTTACGGTGGCGCTGTAACAGGAAG ATGATCACAGGCCCGCTGCAGTACTCTGTCCAGGTGGCGCATGACAACACAGTGGTGGCCTCACGGAAGTATATTCATAAGTGGATTTCT TATGGGTCAGGTGGTGGAGACATTTGTGAATATCTACACAAAGATTTGCATACAATCAAAGGGAACACCCACGGGATGCCGTGTATGTTT CCCTTCCAGTATAACCATCAGTGGCATCATGAATGTACCCGTGAAGGTCGGGAAGATGACTTACTGTGGTGTGCCACGACAAGCCGTTAT GAAAGAGATGAAAAGTGGGGATTTTGCCCTGATCCCACCTCTGCAGAAGTAGGTTGTGATACTATTTGGGAGAAGGACCTCAATTCACAC ATTTGCTACCAGTTCAACCTGCTTTCATCTCTCTCTTGGAGTGAGGCACATTCTTCATGCCAGATGCAAGGAGGTACGCTGTTAAGTATT ACAGATGAAACTGAAGAAAATTTCATAAGGGAGCACATGAGCAGTAAAACAGTGGAGGTGTGGATGGGCCTCAATCAGCTGGATGAACAC GCTGGCTGGCAGTGGTCTGATGGAACGCCGCTCAACTATCTGAATTGGAGCCCAGAGGTAAATTTTGAGCCATTTGTTGAAGATCACTGT GGAACATTTAGTTCATTTATGCCAAGTGCCTGGAGGAGTCGGGATTGTGAGTCCACCTTGCCATATATATGTAAAAAATATCTAAACCAC ATTGATCATGAAATAGTTGAAAAAGATGCGTGGAAATATTATGCTACCCACTGTGAGCCTGGCTGGAATCCCTACAATCGTAATTGCTAC AAACTTCAGAAAGAAGAAAAGACCTGGCATGAGGCTCTGCGTTCTTGTCAGGCTGATAACAGTGCATTAATAGACATAACCTCATTAGCA GAGGTGGAGTTTCTTGTAACCCTCCTTGGAGATGAAAATGCATCAGAAACATGGATTGGTTTGAGCAGCAATAAAATTCCAGTTTCCTTT GAATGGTCTAATGACTCTTCAGTCATCTTTACTAATTGGCACACACTTGAGCCCCACATTTTTCCAAATAGAAGCCAGCTGTGTGTCTCA GCAGAGCAGTCTGAGGGACACTGGAAAGTCAAAAATTGTGAAGAAAGACTTTTTTACATTTGTAAAAAAGCAGGCCATGTCCTCTCTGAT GCTGAATCAGGATGTCAAGAGGGATGGGAGAGACATGGTGGATTCTGTTACAAAATTGACACAGTCCTTCGAAGCTTTGACCAAGCTTCC AGCGGTTATTACTGTCCTCCTGCACTTGTAACCATTACAAACAGGTTTGAACAGGCTTTTATTACCAGTTTGATCAGTAGTGTGGTAAAA ATGAAGGACAGTTATTTTTGGATAGCTCTTCAGGACCAAAATGATACGGGAGAATACACTTGGAAGCCAGTAGGGCAGAAACCCGAGCCG GTGCAGTACACACACTGGAACACACACCAGCCGCGCTACAGTGGTGGCTGTGTTGCCATGCGAGGAAGGCATCCACTTGGTCGCTGGGAA GTGAAGCACTGTCGGCACTTTAAGGCAATGTCCTTGTGCAAGCAGCCAGTTGAAAATCAGGAAAAAGCAGAGTATGAAGAGAGATGGCCC TTTCACCCCTGCTATTTGGACTGGGAGTCAGAGCCTGGTCTGGCCAGTTGCTTCAAGGTATTTCATAGTGAAAAAGTTCTGATGAAAAGA ACATGGAGAGAAGCTGAAGCATTTTGCGAAGAATTTGGAGCTCATCTTGCAAGCTTTGCCCATATTGAGGAAGAGAATTTTGTGAATGAG CTCTTACATTCAAAATTTAATTGGACAGAAGAAAGGCAGTTCTGGATTGGATTTAATAAAAGAAACCCACTGAATGCCGGCTCATGGGAG TGGTCTGATAGAACTCCTGTTGTCTCTTCGTTTTTAGACAACACTTATTTTGGAGAAGATGCAAGAAACTGTGCTGTTTATAAGGCAAAC AAAACATTGCTGCCCTTACACTGTGGTTCCAAACGTGAATGGATATGCAAAATCCCAAGAGATGTGAAACCCAAGATTCCGTTCTGGTAC CAGTACGATGTACCCTGGCTCTTTTATCAGGATGCAGAATACCTTTTTCATACCTTTGCCTCAGAATGGTTGAACTTTGAGTTTGTCTGT AGCTGGCTGCACAGTGATCTTCTCACAATTCATTCTGCACATGAGCAAGAATTCATCCACAGCAAAATAAAAGCGAATTACGCAAAACTT ATTCCTGGAGCTACAGTAGGTCTACTTCAGAAGGACTCCGGAAACATTCTCCAGCTGATCATCTCAGCTTATGAAGAACTGCGGTCTGAG GTGGAACTGGAAGTATTAGGAGACACTGAAGGACTCAACTTGTCATTTACAGCCATCTGTAACAACGGTACCCTCTTCCAACACCAAAAG AAATGCTCTCACATGAAAGTGGGAGACACAGCTTCCTTCAGCGTGACTGTGAATATCCCACACTGCGAGAGAAGAAGCAGGCACATTATC ATAAAGCCTGTGGGGCTGGGGGATGCCCTGGAATTACTTGTCAGCCCAGAATGCAACTGCGACTGTCAGAAAGAAGTGGAAGTGAACAGC TCCAAATGTCACCACGGGAACGGCTCTTTCCAGTGTGGGGTGTGTGCCTGCCACCCTGGCCACATGGGGCCTCGCTGTGAGTGTGGCGAG GACATGCTGAGCACAGATTCCTGCAAGGAGGCCCCAGATCATCCCTCCTGCAGCGGAAGGGGTGACTGCTACTGTGGGCAGTGTATCTGC CACTTGTCTCCCTATGGAAACATTTATGGGCCTTATTGCCAGTGTGACAATTTCTCCTGCGTGAGACACAAAGGGCTGCTCTGCGGAGGT AACGGCGACTGTGACTGTGGTGAATGTGTGTGCAGGAGCGGCTGGACTGGCGAGTACTGCAACTGCACCACCAGCACGGACTCCTGCGTC TCTGAAGATGGAGTGCTCTGCAGCGGGCGCGGGGACTGTGTTTGTGGCAAGTGTGTTTGCACAAACCCTGGAGCCTCAGGACCAACCTGT GAACGATGTCCTACCTGTGGTGACCCCTGTAACTCTAAACGGAGCTGCATTGAGTGCCACCTGTCAGCAGCTGGCCAAGCCCGAGAAGAA TGTGTGGACAAGTGCAAACTAGCTGGTGCGACCATCAGTGAAGAAGAAGATTTCTCAAAGGATGGTTCTGTTTCCTGCTCTCTGCAAGGA GAAAATGAATGTCTTATTACATTCCTAATAACTACAGATAATGAGGGGAAAACCATCATTCACAGCATCAATGAAAAAGATTGTCCGAAG CCTCCAAACATTCCCATGATCATGTTAGGGGTTTCCCTGGCTATTCTTCTCATCGGGGTTGTCCTACTGTGCATCTGGAAGCTACTGGTG TCATTTCATGATCGTAAAGAAGTTGCCAAATTTGAAGCAGAACGATCAAAAGCCAAGTGGCAAACGGGAACCAATCCACTCTACAGAGGA >In-frame_PLA2R1_ENST00000392771_chr2_160832579_-_ITGB6_ENST00000283249_chr2_160998582_-_3945nt ATGCTGCTGTCGCCGTCGCTGCTGCTGCTGCTGCTGCTGGGGGCGCCGCGGGGCTGCGCCGAGGGTGTGGCGGCGGCGCTTACCCCCGAG CGGCTCCTGGAGTGGCAGGATAAAGGAATATTTGTTATCCAAAGTGAGAGTCTCAAGAAATGCATTCAAGCAGGTAAATCGGTTCTGACC CTGGAGAACTGCAAGCAAGCAAACAAGCACATGCTGTGGAAATGGGTTTCAAACCATGGCCTCTTTAACATAGGAGGCAGTGGTTGCCTG GGCCTGAATTTCTCCGCCCCAGAGCAGCCATTAAGCTTATATGAATGTGACTCCACCCTCGTTTCCTTACGGTGGCGCTGTAACAGGAAG ATGATCACAGGCCCGCTGCAGTACTCTGTCCAGGTGGCGCATGACAACACAGTGGTGGCCTCACGGAAGTATATTCATAAGTGGATTTCT TATGGGTCAGGTGGTGGAGACATTTGTGAATATCTACACAAAGATTTGCATACAATCAAAGGGAACACCCACGGGATGCCGTGTATGTTT CCCTTCCAGTATAACCATCAGTGGCATCATGAATGTACCCGTGAAGGTCGGGAAGATGACTTACTGTGGTGTGCCACGACAAGCCGTTAT GAAAGAGATGAAAAGTGGGGATTTTGCCCTGATCCCACCTCTGCAGAAGTAGGTTGTGATACTATTTGGGAGAAGGACCTCAATTCACAC ATTTGCTACCAGTTCAACCTGCTTTCATCTCTCTCTTGGAGTGAGGCACATTCTTCATGCCAGATGCAAGGAGGTACGCTGTTAAGTATT ACAGATGAAACTGAAGAAAATTTCATAAGGGAGCACATGAGCAGTAAAACAGTGGAGGTGTGGATGGGCCTCAATCAGCTGGATGAACAC GCTGGCTGGCAGTGGTCTGATGGAACGCCGCTCAACTATCTGAATTGGAGCCCAGAGGTAAATTTTGAGCCATTTGTTGAAGATCACTGT GGAACATTTAGTTCATTTATGCCAAGTGCCTGGAGGAGTCGGGATTGTGAGTCCACCTTGCCATATATATGTAAAAAATATCTAAACCAC ATTGATCATGAAATAGTTGAAAAAGATGCGTGGAAATATTATGCTACCCACTGTGAGCCTGGCTGGAATCCCTACAATCGTAATTGCTAC AAACTTCAGAAAGAAGAAAAGACCTGGCATGAGGCTCTGCGTTCTTGTCAGGCTGATAACAGTGCATTAATAGACATAACCTCATTAGCA GAGGTGGAGTTTCTTGTAACCCTCCTTGGAGATGAAAATGCATCAGAAACATGGATTGGTTTGAGCAGCAATAAAATTCCAGTTTCCTTT GAATGGTCTAATGACTCTTCAGTCATCTTTACTAATTGGCACACACTTGAGCCCCACATTTTTCCAAATAGAAGCCAGCTGTGTGTCTCA GCAGAGCAGTCTGAGGGACACTGGAAAGTCAAAAATTGTGAAGAAAGACTTTTTTACATTTGTAAAAAAGCAGGCCATGTCCTCTCTGAT GCTGAATCAGGATGTCAAGAGGGATGGGAGAGACATGGTGGATTCTGTTACAAAATTGACACAGTCCTTCGAAGCTTTGACCAAGCTTCC AGCGGTTATTACTGTCCTCCTGCACTTGTAACCATTACAAACAGGTTTGAACAGGCTTTTATTACCAGTTTGATCAGTAGTGTGGTAAAA ATGAAGGACAGTTATTTTTGGATAGCTCTTCAGGACCAAAATGATACGGGAGAATACACTTGGAAGCCAGTAGGGCAGAAACCCGAGCCG GTGCAGTACACACACTGGAACACACACCAGCCGCGCTACAGTGGTGGCTGTGTTGCCATGCGAGGAAGGCATCCACTTGGTCGCTGGGAA GTGAAGCACTGTCGGCACTTTAAGGCAATGTCCTTGTGCAAGCAGCCAGTTGAAAATCAGGAAAAAGCAGAGTATGAAGAGAGATGGCCC TTTCACCCCTGCTATTTGGACTGGGAGTCAGAGCCTGGTCTGGCCAGTTGCTTCAAGGTATTTCATAGTGAAAAAGTTCTGATGAAAAGA ACATGGAGAGAAGCTGAAGCATTTTGCGAAGAATTTGGAGCTCATCTTGCAAGCTTTGCCCATATTGAGGAAGAGAATTTTGTGAATGAG CTCTTACATTCAAAATTTAATTGGACAGAAGAAAGGCAGTTCTGGATTGGATTTAATAAAAGAAACCCACTGAATGCCGGCTCATGGGAG TGGTCTGATAGAACTCCTGTTGTCTCTTCGTTTTTAGACAACACTTATTTTGGAGAAGATGCAAGAAACTGTGCTGTTTATAAGGCAAAC AAAACATTGCTGCCCTTACACTGTGGTTCCAAACGTGAATGGATATGCAAAATCCCAAGAGATGTGAAACCCAAGATTCCGTTCTGGTAC CAGTACGATGTACCCTGGCTCTTTTATCAGGATGCAGAATACCTTTTTCATACCTTTGCCTCAGAATGGTTGAACTTTGAGTTTGTCTGT AGCTGGCTGCACAGTGATCTTCTCACAATTCATTCTGCACATGAGCAAGAATTCATCCACAGCAAAATAAAAGCGAATTACGCAAAACTT ATTCCTGGAGCTACAGTAGGTCTACTTCAGAAGGACTCCGGAAACATTCTCCAGCTGATCATCTCAGCTTATGAAGAACTGCGGTCTGAG GTGGAACTGGAAGTATTAGGAGACACTGAAGGACTCAACTTGTCATTTACAGCCATCTGTAACAACGGTACCCTCTTCCAACACCAAAAG AAATGCTCTCACATGAAAGTGGGAGACACAGCTTCCTTCAGCGTGACTGTGAATATCCCACACTGCGAGAGAAGAAGCAGGCACATTATC ATAAAGCCTGTGGGGCTGGGGGATGCCCTGGAATTACTTGTCAGCCCAGAATGCAACTGCGACTGTCAGAAAGAAGTGGAAGTGAACAGC TCCAAATGTCACCACGGGAACGGCTCTTTCCAGTGTGGGGTGTGTGCCTGCCACCCTGGCCACATGGGGCCTCGCTGTGAGTGTGGCGAG GACATGCTGAGCACAGATTCCTGCAAGGAGGCCCCAGATCATCCCTCCTGCAGCGGAAGGGGTGACTGCTACTGTGGGCAGTGTATCTGC CACTTGTCTCCCTATGGAAACATTTATGGGCCTTATTGCCAGTGTGACAATTTCTCCTGCGTGAGACACAAAGGGCTGCTCTGCGGAGGT AACGGCGACTGTGACTGTGGTGAATGTGTGTGCAGGAGCGGCTGGACTGGCGAGTACTGCAACTGCACCACCAGCACGGACTCCTGCGTC TCTGAAGATGGAGTGCTCTGCAGCGGGCGCGGGGACTGTGTTTGTGGCAAGTGTGTTTGCACAAACCCTGGAGCCTCAGGACCAACCTGT GAACGATGTCCTACCTGTGGTGACCCCTGTAACTCTAAACGGAGCTGCATTGAGTGCCACCTGTCAGCAGCTGGCCAAGCCCGAGAAGAA TGTGTGGACAAGTGCAAACTAGCTGGTGCGACCATCAGTGAAGAAGAAGATTTCTCAAAGGATGGTTCTGTTTCCTGCTCTCTGCAAGGA GAAAATGAATGTCTTATTACATTCCTAATAACTACAGATAATGAGGGGAAAACCATCATTCACAGCATCAATGAAAAAGATTGTCCGAAG CCTCCAAACATTCCCATGATCATGTTAGGGGTTTCCCTGGCTATTCTTCTCATCGGGGTTGTCCTACTGTGCATCTGGAAGCTACTGGTG TCATTTCATGATCGTAAAGAAGTTGCCAAATTTGAAGCAGAACGATCAAAAGCCAAGTGGCAAACGGGAACCAATCCACTCTACAGAGGA |
| * Fusion transcript sequences (Full-length transcript). |
| >In-frame_PLA2R1_ENST00000283243_chr2_160832579_-_ITGB6_ENST00000283249_chr2_160998582_-_6222nt CCCGAGTGTCGGTTCACTGTGGAGACAGCGGTGGCGGAGTGGGTCTCCAGGGCTCTGGGCTGGCAAGGCCCCCGGAGGGGGTGGGGCGCG GAGGAGGCTACGGATCCGCTTCCGCGCGGCGGGGCCGGGTGCTTGGGACGCGGCTCTGGGCTCCCGGGATAAGGGGCTCCCGGGACAAGG GGCTCCCGGAGAGCCCAGTGGTTAGCGATGCTGCTGTCGCCGTCGCTGCTGCTGCTGCTGCTGCTGGGGGCGCCGCGGGGCTGCGCCGAG GGTGTGGCGGCGGCGCTTACCCCCGAGCGGCTCCTGGAGTGGCAGGATAAAGGAATATTTGTTATCCAAAGTGAGAGTCTCAAGAAATGC ATTCAAGCAGGTAAATCGGTTCTGACCCTGGAGAACTGCAAGCAAGCAAACAAGCACATGCTGTGGAAATGGGTTTCAAACCATGGCCTC TTTAACATAGGAGGCAGTGGTTGCCTGGGCCTGAATTTCTCCGCCCCAGAGCAGCCATTAAGCTTATATGAATGTGACTCCACCCTCGTT TCCTTACGGTGGCGCTGTAACAGGAAGATGATCACAGGCCCGCTGCAGTACTCTGTCCAGGTGGCGCATGACAACACAGTGGTGGCCTCA CGGAAGTATATTCATAAGTGGATTTCTTATGGGTCAGGTGGTGGAGACATTTGTGAATATCTACACAAAGATTTGCATACAATCAAAGGG AACACCCACGGGATGCCGTGTATGTTTCCCTTCCAGTATAACCATCAGTGGCATCATGAATGTACCCGTGAAGGTCGGGAAGATGACTTA CTGTGGTGTGCCACGACAAGCCGTTATGAAAGAGATGAAAAGTGGGGATTTTGCCCTGATCCCACCTCTGCAGAAGTAGGTTGTGATACT ATTTGGGAGAAGGACCTCAATTCACACATTTGCTACCAGTTCAACCTGCTTTCATCTCTCTCTTGGAGTGAGGCACATTCTTCATGCCAG ATGCAAGGAGGTACGCTGTTAAGTATTACAGATGAAACTGAAGAAAATTTCATAAGGGAGCACATGAGCAGTAAAACAGTGGAGGTGTGG ATGGGCCTCAATCAGCTGGATGAACACGCTGGCTGGCAGTGGTCTGATGGAACGCCGCTCAACTATCTGAATTGGAGCCCAGAGGTAAAT TTTGAGCCATTTGTTGAAGATCACTGTGGAACATTTAGTTCATTTATGCCAAGTGCCTGGAGGAGTCGGGATTGTGAGTCCACCTTGCCA TATATATGTAAAAAATATCTAAACCACATTGATCATGAAATAGTTGAAAAAGATGCGTGGAAATATTATGCTACCCACTGTGAGCCTGGC TGGAATCCCTACAATCGTAATTGCTACAAACTTCAGAAAGAAGAAAAGACCTGGCATGAGGCTCTGCGTTCTTGTCAGGCTGATAACAGT GCATTAATAGACATAACCTCATTAGCAGAGGTGGAGTTTCTTGTAACCCTCCTTGGAGATGAAAATGCATCAGAAACATGGATTGGTTTG AGCAGCAATAAAATTCCAGTTTCCTTTGAATGGTCTAATGACTCTTCAGTCATCTTTACTAATTGGCACACACTTGAGCCCCACATTTTT CCAAATAGAAGCCAGCTGTGTGTCTCAGCAGAGCAGTCTGAGGGACACTGGAAAGTCAAAAATTGTGAAGAAAGACTTTTTTACATTTGT AAAAAAGCAGGCCATGTCCTCTCTGATGCTGAATCAGGATGTCAAGAGGGATGGGAGAGACATGGTGGATTCTGTTACAAAATTGACACA GTCCTTCGAAGCTTTGACCAAGCTTCCAGCGGTTATTACTGTCCTCCTGCACTTGTAACCATTACAAACAGGTTTGAACAGGCTTTTATT ACCAGTTTGATCAGTAGTGTGGTAAAAATGAAGGACAGTTATTTTTGGATAGCTCTTCAGGACCAAAATGATACGGGAGAATACACTTGG AAGCCAGTAGGGCAGAAACCCGAGCCGGTGCAGTACACACACTGGAACACACACCAGCCGCGCTACAGTGGTGGCTGTGTTGCCATGCGA GGAAGGCATCCACTTGGTCGCTGGGAAGTGAAGCACTGTCGGCACTTTAAGGCAATGTCCTTGTGCAAGCAGCCAGTTGAAAATCAGGAA AAAGCAGAGTATGAAGAGAGATGGCCCTTTCACCCCTGCTATTTGGACTGGGAGTCAGAGCCTGGTCTGGCCAGTTGCTTCAAGGTATTT CATAGTGAAAAAGTTCTGATGAAAAGAACATGGAGAGAAGCTGAAGCATTTTGCGAAGAATTTGGAGCTCATCTTGCAAGCTTTGCCCAT ATTGAGGAAGAGAATTTTGTGAATGAGCTCTTACATTCAAAATTTAATTGGACAGAAGAAAGGCAGTTCTGGATTGGATTTAATAAAAGA AACCCACTGAATGCCGGCTCATGGGAGTGGTCTGATAGAACTCCTGTTGTCTCTTCGTTTTTAGACAACACTTATTTTGGAGAAGATGCA AGAAACTGTGCTGTTTATAAGGCAAACAAAACATTGCTGCCCTTACACTGTGGTTCCAAACGTGAATGGATATGCAAAATCCCAAGAGAT GTGAAACCCAAGATTCCGTTCTGGTACCAGTACGATGTACCCTGGCTCTTTTATCAGGATGCAGAATACCTTTTTCATACCTTTGCCTCA GAATGGTTGAACTTTGAGTTTGTCTGTAGCTGGCTGCACAGTGATCTTCTCACAATTCATTCTGCACATGAGCAAGAATTCATCCACAGC AAAATAAAAGCGAATTACGCAAAACTTATTCCTGGAGCTACAGTAGGTCTACTTCAGAAGGACTCCGGAAACATTCTCCAGCTGATCATC TCAGCTTATGAAGAACTGCGGTCTGAGGTGGAACTGGAAGTATTAGGAGACACTGAAGGACTCAACTTGTCATTTACAGCCATCTGTAAC AACGGTACCCTCTTCCAACACCAAAAGAAATGCTCTCACATGAAAGTGGGAGACACAGCTTCCTTCAGCGTGACTGTGAATATCCCACAC TGCGAGAGAAGAAGCAGGCACATTATCATAAAGCCTGTGGGGCTGGGGGATGCCCTGGAATTACTTGTCAGCCCAGAATGCAACTGCGAC TGTCAGAAAGAAGTGGAAGTGAACAGCTCCAAATGTCACCACGGGAACGGCTCTTTCCAGTGTGGGGTGTGTGCCTGCCACCCTGGCCAC ATGGGGCCTCGCTGTGAGTGTGGCGAGGACATGCTGAGCACAGATTCCTGCAAGGAGGCCCCAGATCATCCCTCCTGCAGCGGAAGGGGT GACTGCTACTGTGGGCAGTGTATCTGCCACTTGTCTCCCTATGGAAACATTTATGGGCCTTATTGCCAGTGTGACAATTTCTCCTGCGTG AGACACAAAGGGCTGCTCTGCGGAGGTAACGGCGACTGTGACTGTGGTGAATGTGTGTGCAGGAGCGGCTGGACTGGCGAGTACTGCAAC TGCACCACCAGCACGGACTCCTGCGTCTCTGAAGATGGAGTGCTCTGCAGCGGGCGCGGGGACTGTGTTTGTGGCAAGTGTGTTTGCACA AACCCTGGAGCCTCAGGACCAACCTGTGAACGATGTCCTACCTGTGGTGACCCCTGTAACTCTAAACGGAGCTGCATTGAGTGCCACCTG TCAGCAGCTGGCCAAGCCCGAGAAGAATGTGTGGACAAGTGCAAACTAGCTGGTGCGACCATCAGTGAAGAAGAAGATTTCTCAAAGGAT GGTTCTGTTTCCTGCTCTCTGCAAGGAGAAAATGAATGTCTTATTACATTCCTAATAACTACAGATAATGAGGGGAAAACCATCATTCAC AGCATCAATGAAAAAGATTGTCCGAAGCCTCCAAACATTCCCATGATCATGTTAGGGGTTTCCCTGGCTATTCTTCTCATCGGGGTTGTC CTACTGTGCATCTGGAAGCTACTGGTGTCATTTCATGATCGTAAAGAAGTTGCCAAATTTGAAGCAGAACGATCAAAAGCCAAGTGGCAA ACGGGAACCAATCCACTCTACAGAGGATCCACAAGTACTTTTAAAAATGTAACTTATAAACACAGGGAAAAACAAAAGGTAGACCTTTCC ACAGATTGCTAGAACTACTTTATGCATGAAAAAAGTCTGTTTCACTGATATGAAATGTTAATGCACTATTTAATTTTTTTCTCTTTGTTG CTTCAAAATGAGGTTGGTTTAAGATAATAATAGGACATCTGCAGATAAGTCATCCTCTACATGAAGGTGACAGACTGTTGGCAGTTTCAA AATAATCAAGAAGAGAAATATCCTTAGCAAAGAGATGACTTTGGGGATCATTTGAGGAATACTAACTCTGTTGCATTAATGCTTCAAAAA ATCATCAAATGATTCATGGGGGCCTGATTTGCATTTGAAAAATGTTTGAAATTAGAGTCTCATTTGTTTCAGGAATGCAGCTACCTGAGT TTTTTGTCTCGGCAAAGTCACAAAGCCCATATACTCACATTGTGTGTCTATACTTGCCAATTAATTCTAAACTTGTAGGAAATATGCCCT CTCTTAAAGGAGAATTTTTTTTAAATCTCTGAGAAATGAGATTCTGAGTTTATTTCAGCTAAAAGGTTGCAATTCTTCTGAAGATATCTC AAATATAAGGTTGAAAGTTAAGTGTTAATAATTTTTGTGAATTTATACACACCTAAACGTTAAGTACACAAATATTTTATTTGTTTTACA AATAAGGAATAAGTAATTTATAAATTAAGAAGTTACCTATAAAAATAAAAAGATAACAACCCTATCATATAGCTTATTTTTAAATTACCT GAAAAACGATATTCTACACTGTTTCCTTTTTGACTCTGAGTTTTCAAACTGTTACTTCTCCCATATTTCTCAATCCATTTCACTCAGTTG CACAGTCTTTTAAACCCTGTAATTGTCATACCAAAGTTTCTTTTTAAAAAAAAATTACTTTAAATGCTTAGTTTATTCAAAGAGCGATCC AATAATATAAAAGGAACATGTGTTAAACACAATAAAATTTTAAATGGCTCTAAATCAAGCACATCAAGAGTATACAAGTCTTAAAGGCTT TTTAATACATACTCTTTTCCCATCTATGTAACCCAACTTGCACATTTCAGCTGCATGTGGTGAATATGCATCATATATTTACTTTAAGAG GTAAGATTTTACTTGCAAAATACATGTGCAAATTAGGGATCCATCAGTTGATGGAAGAGATGGACTCTAGAATATTATTTCTTGTGGTTA TTACTCCTTTACAAAGCACTTTCGTCTCACTTGATCCTCATAAGGAAACTAAGGCTCAGAATGAGTAGAGCTGGGTTCAGAATCTAGCTC TTCTAACTCCAAGCCATCTCCTCTTTCCACTGCAGGAAACTGCCTCTTTTGTCAGTGAAATAATAGAAAGATTGTGTTAGTTAAGTGATA ACTGTCATTTGTTTGAAAATGTTCGAGACTGAACAAATAGCATTTAAACTGCTGGCATATAGATGAGATATTGTACTTTTGTGCAATGTT TATTACCTTTGATTAAATTGTAATGTGAAGCTTTTACTAGGTGAATAGTTCATTATGTAGTGGAGGCTTCGTGGTTGTCCATTGAATTGT CACAGCAAAATCTATAAGTTTCTTCAATTCTACAAGATAGATCCATATACCTTTGATCACTTGGAGACTCTTTTTTTGCTGGTTTCTAGA TAACTCAGGTAAATCAGACCTTTACAGAGTACAGGGCTAGGTGAAAGAATTACTGAAAAATCACCTTGAAAATCCGAAGGGCTGATATAC CCTTTATGTTCCTGACTGATGCGCAGAACCTGGGGGAAATCTACAGCAATATACAGGTTGCAATGCTGATAACACAACAGCAATCCTCTC CTCTACGTGGACTTACTGTTGTTTTTTTAATTATTATTGGAATGGGATTTTAGAAAATAGAAGTTACCTTTGTGTGTGTTTTAGGGAAGG TAGAGAAGAATCTGCTCTTTCTCTGAATACTGTTTTGACCCCAGGCAGGACCTTGGAAAGGCCAAAACATTAACAGTAGTACTTCTGTTC ACTGAAGAGTTATGTTACATGAAGATAAAATGGTTTTGTCGTGTTTATTATTGTATTTTGTGTTGATATAAATAAACATGGTAATTTAAA >In-frame_PLA2R1_ENST00000392771_chr2_160832579_-_ITGB6_ENST00000283249_chr2_160998582_-_6222nt CCCGAGTGTCGGTTCACTGTGGAGACAGCGGTGGCGGAGTGGGTCTCCAGGGCTCTGGGCTGGCAAGGCCCCCGGAGGGGGTGGGGCGCG GAGGAGGCTACGGATCCGCTTCCGCGCGGCGGGGCCGGGTGCTTGGGACGCGGCTCTGGGCTCCCGGGATAAGGGGCTCCCGGGACAAGG GGCTCCCGGAGAGCCCAGTGGTTAGCGATGCTGCTGTCGCCGTCGCTGCTGCTGCTGCTGCTGCTGGGGGCGCCGCGGGGCTGCGCCGAG GGTGTGGCGGCGGCGCTTACCCCCGAGCGGCTCCTGGAGTGGCAGGATAAAGGAATATTTGTTATCCAAAGTGAGAGTCTCAAGAAATGC ATTCAAGCAGGTAAATCGGTTCTGACCCTGGAGAACTGCAAGCAAGCAAACAAGCACATGCTGTGGAAATGGGTTTCAAACCATGGCCTC TTTAACATAGGAGGCAGTGGTTGCCTGGGCCTGAATTTCTCCGCCCCAGAGCAGCCATTAAGCTTATATGAATGTGACTCCACCCTCGTT TCCTTACGGTGGCGCTGTAACAGGAAGATGATCACAGGCCCGCTGCAGTACTCTGTCCAGGTGGCGCATGACAACACAGTGGTGGCCTCA CGGAAGTATATTCATAAGTGGATTTCTTATGGGTCAGGTGGTGGAGACATTTGTGAATATCTACACAAAGATTTGCATACAATCAAAGGG AACACCCACGGGATGCCGTGTATGTTTCCCTTCCAGTATAACCATCAGTGGCATCATGAATGTACCCGTGAAGGTCGGGAAGATGACTTA CTGTGGTGTGCCACGACAAGCCGTTATGAAAGAGATGAAAAGTGGGGATTTTGCCCTGATCCCACCTCTGCAGAAGTAGGTTGTGATACT ATTTGGGAGAAGGACCTCAATTCACACATTTGCTACCAGTTCAACCTGCTTTCATCTCTCTCTTGGAGTGAGGCACATTCTTCATGCCAG ATGCAAGGAGGTACGCTGTTAAGTATTACAGATGAAACTGAAGAAAATTTCATAAGGGAGCACATGAGCAGTAAAACAGTGGAGGTGTGG ATGGGCCTCAATCAGCTGGATGAACACGCTGGCTGGCAGTGGTCTGATGGAACGCCGCTCAACTATCTGAATTGGAGCCCAGAGGTAAAT TTTGAGCCATTTGTTGAAGATCACTGTGGAACATTTAGTTCATTTATGCCAAGTGCCTGGAGGAGTCGGGATTGTGAGTCCACCTTGCCA TATATATGTAAAAAATATCTAAACCACATTGATCATGAAATAGTTGAAAAAGATGCGTGGAAATATTATGCTACCCACTGTGAGCCTGGC TGGAATCCCTACAATCGTAATTGCTACAAACTTCAGAAAGAAGAAAAGACCTGGCATGAGGCTCTGCGTTCTTGTCAGGCTGATAACAGT GCATTAATAGACATAACCTCATTAGCAGAGGTGGAGTTTCTTGTAACCCTCCTTGGAGATGAAAATGCATCAGAAACATGGATTGGTTTG AGCAGCAATAAAATTCCAGTTTCCTTTGAATGGTCTAATGACTCTTCAGTCATCTTTACTAATTGGCACACACTTGAGCCCCACATTTTT CCAAATAGAAGCCAGCTGTGTGTCTCAGCAGAGCAGTCTGAGGGACACTGGAAAGTCAAAAATTGTGAAGAAAGACTTTTTTACATTTGT AAAAAAGCAGGCCATGTCCTCTCTGATGCTGAATCAGGATGTCAAGAGGGATGGGAGAGACATGGTGGATTCTGTTACAAAATTGACACA GTCCTTCGAAGCTTTGACCAAGCTTCCAGCGGTTATTACTGTCCTCCTGCACTTGTAACCATTACAAACAGGTTTGAACAGGCTTTTATT ACCAGTTTGATCAGTAGTGTGGTAAAAATGAAGGACAGTTATTTTTGGATAGCTCTTCAGGACCAAAATGATACGGGAGAATACACTTGG AAGCCAGTAGGGCAGAAACCCGAGCCGGTGCAGTACACACACTGGAACACACACCAGCCGCGCTACAGTGGTGGCTGTGTTGCCATGCGA GGAAGGCATCCACTTGGTCGCTGGGAAGTGAAGCACTGTCGGCACTTTAAGGCAATGTCCTTGTGCAAGCAGCCAGTTGAAAATCAGGAA AAAGCAGAGTATGAAGAGAGATGGCCCTTTCACCCCTGCTATTTGGACTGGGAGTCAGAGCCTGGTCTGGCCAGTTGCTTCAAGGTATTT CATAGTGAAAAAGTTCTGATGAAAAGAACATGGAGAGAAGCTGAAGCATTTTGCGAAGAATTTGGAGCTCATCTTGCAAGCTTTGCCCAT ATTGAGGAAGAGAATTTTGTGAATGAGCTCTTACATTCAAAATTTAATTGGACAGAAGAAAGGCAGTTCTGGATTGGATTTAATAAAAGA AACCCACTGAATGCCGGCTCATGGGAGTGGTCTGATAGAACTCCTGTTGTCTCTTCGTTTTTAGACAACACTTATTTTGGAGAAGATGCA AGAAACTGTGCTGTTTATAAGGCAAACAAAACATTGCTGCCCTTACACTGTGGTTCCAAACGTGAATGGATATGCAAAATCCCAAGAGAT GTGAAACCCAAGATTCCGTTCTGGTACCAGTACGATGTACCCTGGCTCTTTTATCAGGATGCAGAATACCTTTTTCATACCTTTGCCTCA GAATGGTTGAACTTTGAGTTTGTCTGTAGCTGGCTGCACAGTGATCTTCTCACAATTCATTCTGCACATGAGCAAGAATTCATCCACAGC AAAATAAAAGCGAATTACGCAAAACTTATTCCTGGAGCTACAGTAGGTCTACTTCAGAAGGACTCCGGAAACATTCTCCAGCTGATCATC TCAGCTTATGAAGAACTGCGGTCTGAGGTGGAACTGGAAGTATTAGGAGACACTGAAGGACTCAACTTGTCATTTACAGCCATCTGTAAC AACGGTACCCTCTTCCAACACCAAAAGAAATGCTCTCACATGAAAGTGGGAGACACAGCTTCCTTCAGCGTGACTGTGAATATCCCACAC TGCGAGAGAAGAAGCAGGCACATTATCATAAAGCCTGTGGGGCTGGGGGATGCCCTGGAATTACTTGTCAGCCCAGAATGCAACTGCGAC TGTCAGAAAGAAGTGGAAGTGAACAGCTCCAAATGTCACCACGGGAACGGCTCTTTCCAGTGTGGGGTGTGTGCCTGCCACCCTGGCCAC ATGGGGCCTCGCTGTGAGTGTGGCGAGGACATGCTGAGCACAGATTCCTGCAAGGAGGCCCCAGATCATCCCTCCTGCAGCGGAAGGGGT GACTGCTACTGTGGGCAGTGTATCTGCCACTTGTCTCCCTATGGAAACATTTATGGGCCTTATTGCCAGTGTGACAATTTCTCCTGCGTG AGACACAAAGGGCTGCTCTGCGGAGGTAACGGCGACTGTGACTGTGGTGAATGTGTGTGCAGGAGCGGCTGGACTGGCGAGTACTGCAAC TGCACCACCAGCACGGACTCCTGCGTCTCTGAAGATGGAGTGCTCTGCAGCGGGCGCGGGGACTGTGTTTGTGGCAAGTGTGTTTGCACA AACCCTGGAGCCTCAGGACCAACCTGTGAACGATGTCCTACCTGTGGTGACCCCTGTAACTCTAAACGGAGCTGCATTGAGTGCCACCTG TCAGCAGCTGGCCAAGCCCGAGAAGAATGTGTGGACAAGTGCAAACTAGCTGGTGCGACCATCAGTGAAGAAGAAGATTTCTCAAAGGAT GGTTCTGTTTCCTGCTCTCTGCAAGGAGAAAATGAATGTCTTATTACATTCCTAATAACTACAGATAATGAGGGGAAAACCATCATTCAC AGCATCAATGAAAAAGATTGTCCGAAGCCTCCAAACATTCCCATGATCATGTTAGGGGTTTCCCTGGCTATTCTTCTCATCGGGGTTGTC CTACTGTGCATCTGGAAGCTACTGGTGTCATTTCATGATCGTAAAGAAGTTGCCAAATTTGAAGCAGAACGATCAAAAGCCAAGTGGCAA ACGGGAACCAATCCACTCTACAGAGGATCCACAAGTACTTTTAAAAATGTAACTTATAAACACAGGGAAAAACAAAAGGTAGACCTTTCC ACAGATTGCTAGAACTACTTTATGCATGAAAAAAGTCTGTTTCACTGATATGAAATGTTAATGCACTATTTAATTTTTTTCTCTTTGTTG CTTCAAAATGAGGTTGGTTTAAGATAATAATAGGACATCTGCAGATAAGTCATCCTCTACATGAAGGTGACAGACTGTTGGCAGTTTCAA AATAATCAAGAAGAGAAATATCCTTAGCAAAGAGATGACTTTGGGGATCATTTGAGGAATACTAACTCTGTTGCATTAATGCTTCAAAAA ATCATCAAATGATTCATGGGGGCCTGATTTGCATTTGAAAAATGTTTGAAATTAGAGTCTCATTTGTTTCAGGAATGCAGCTACCTGAGT TTTTTGTCTCGGCAAAGTCACAAAGCCCATATACTCACATTGTGTGTCTATACTTGCCAATTAATTCTAAACTTGTAGGAAATATGCCCT CTCTTAAAGGAGAATTTTTTTTAAATCTCTGAGAAATGAGATTCTGAGTTTATTTCAGCTAAAAGGTTGCAATTCTTCTGAAGATATCTC AAATATAAGGTTGAAAGTTAAGTGTTAATAATTTTTGTGAATTTATACACACCTAAACGTTAAGTACACAAATATTTTATTTGTTTTACA AATAAGGAATAAGTAATTTATAAATTAAGAAGTTACCTATAAAAATAAAAAGATAACAACCCTATCATATAGCTTATTTTTAAATTACCT GAAAAACGATATTCTACACTGTTTCCTTTTTGACTCTGAGTTTTCAAACTGTTACTTCTCCCATATTTCTCAATCCATTTCACTCAGTTG CACAGTCTTTTAAACCCTGTAATTGTCATACCAAAGTTTCTTTTTAAAAAAAAATTACTTTAAATGCTTAGTTTATTCAAAGAGCGATCC AATAATATAAAAGGAACATGTGTTAAACACAATAAAATTTTAAATGGCTCTAAATCAAGCACATCAAGAGTATACAAGTCTTAAAGGCTT TTTAATACATACTCTTTTCCCATCTATGTAACCCAACTTGCACATTTCAGCTGCATGTGGTGAATATGCATCATATATTTACTTTAAGAG GTAAGATTTTACTTGCAAAATACATGTGCAAATTAGGGATCCATCAGTTGATGGAAGAGATGGACTCTAGAATATTATTTCTTGTGGTTA TTACTCCTTTACAAAGCACTTTCGTCTCACTTGATCCTCATAAGGAAACTAAGGCTCAGAATGAGTAGAGCTGGGTTCAGAATCTAGCTC TTCTAACTCCAAGCCATCTCCTCTTTCCACTGCAGGAAACTGCCTCTTTTGTCAGTGAAATAATAGAAAGATTGTGTTAGTTAAGTGATA ACTGTCATTTGTTTGAAAATGTTCGAGACTGAACAAATAGCATTTAAACTGCTGGCATATAGATGAGATATTGTACTTTTGTGCAATGTT TATTACCTTTGATTAAATTGTAATGTGAAGCTTTTACTAGGTGAATAGTTCATTATGTAGTGGAGGCTTCGTGGTTGTCCATTGAATTGT CACAGCAAAATCTATAAGTTTCTTCAATTCTACAAGATAGATCCATATACCTTTGATCACTTGGAGACTCTTTTTTTGCTGGTTTCTAGA TAACTCAGGTAAATCAGACCTTTACAGAGTACAGGGCTAGGTGAAAGAATTACTGAAAAATCACCTTGAAAATCCGAAGGGCTGATATAC CCTTTATGTTCCTGACTGATGCGCAGAACCTGGGGGAAATCTACAGCAATATACAGGTTGCAATGCTGATAACACAACAGCAATCCTCTC CTCTACGTGGACTTACTGTTGTTTTTTTAATTATTATTGGAATGGGATTTTAGAAAATAGAAGTTACCTTTGTGTGTGTTTTAGGGAAGG TAGAGAAGAATCTGCTCTTTCTCTGAATACTGTTTTGACCCCAGGCAGGACCTTGGAAAGGCCAAAACATTAACAGTAGTACTTCTGTTC ACTGAAGAGTTATGTTACATGAAGATAAAATGGTTTTGTCGTGTTTATTATTGTATTTTGTGTTGATATAAATAAACATGGTAATTTAAA |
Top |
FusionGenePPI for PLA2R1_ITGB6 |
| Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in . |
| Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160) |
| Hgene | Hgene's interactors | Tgene | Tgene's interactors |
| PLA2R1 | ITGB6 | FLNB, FLNA, FN1, FHL2, MAPK1 |
| - Retained PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
| Tgene | ITGB6 | chr2:160832579 | chr2:160998582 | ENST00000283249 | - | 6 | 15 | 731_758 | 339 | 789 | HAX1 |
| Tgene | ITGB6 | chr2:160832579 | chr2:160998582 | ENST00000409872 | - | 7 | 16 | 731_758 | 339 | 789 | HAX1 |
| - Lost PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
| - Retained PPIs, but lost function due to frame-shift fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
Top |
RelatedDrugs for PLA2R1_ITGB6 |
| Drugs targeting genes involved in this fusion gene. (DrugBank Version 5.1.0 2018-04-02) |
| Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
Top |
RelatedDiseases for PLA2R1_ITGB6 |
| Diseases associated with fusion partners. (DisGeNet 4.0) |
| Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
| Hgene | PLA2R1 | C0236969 | Substance-Related Disorders | 1 | CTD_human |
| Tgene | ITGB6 | C4015557 | AMELOGENESIS IMPERFECTA, TYPE IH | 2 | UNIPROT |
| Tgene | ITGB6 | C0000786 | Spontaneous abortion | 1 | CTD_human |
| Tgene | ITGB6 | C0004364 | Autoimmune Diseases | 1 | CTD_human |
| Tgene | ITGB6 | C0008311 | Cholangitis | 1 | CTD_human |
| Tgene | ITGB6 | C0023893 | Liver Cirrhosis, Experimental | 1 | CTD_human |
| Tgene | ITGB6 | C0023895 | Liver diseases | 1 | CTD_human |
| Tgene | ITGB6 | C0034067 | Pulmonary Emphysema | 1 | CTD_human |
| Tgene | ITGB6 | C0524910 | Hepatitis C, Chronic | 1 | CTD_human |
Copyright 2018-Present -The University of Texas Health Science Center at Houston (UTHealth)
|