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Fusion gene ID: 27435 |
FusionGeneSummary for PLA2G2A_FBLN1 |
 Fusion gene summary |
| Fusion gene information | Fusion gene name: PLA2G2A_FBLN1 | Fusion gene ID: 27435 | Hgene | Tgene | Gene symbol | PLA2G2A | FBLN1 | Gene ID | 5320 | 2192 |
| Gene name | phospholipase A2 group IIA | fibulin 1 | |
| Synonyms | MOM1|PLA2|PLA2B|PLA2L|PLA2S|PLAS1|sPLA2 | FBLN|FIBL1 | |
| Cytomap | 1p36.13 | 22q13.31 | |
| Type of gene | protein-coding | protein-coding | |
| Description | phospholipase A2, membrane associatedGIIC sPLA2NPS-PLA2group IIA phospholipase A2non-pancreatic secretory phospholipase A2phosphatidylcholine 2-acylhydrolase 2Aphospholipase A2, group IIA (platelets, synovial fluid) | fibulin-1 | |
| Modification date | 20180519 | 20180522 | |
| UniProtAcc | P14555 | P23142 | |
| Ensembl transtripts involved in fusion gene | ENST00000400520, ENST00000496748, ENST00000375111, | ENST00000348697, ENST00000402984, ENST00000262722, ENST00000327858, ENST00000442170, ENST00000340923, ENST00000476366, | |
| Fusion gene scores | * DoF score | 6 X 2 X 1=12 | 12 X 11 X 7=924 |
| # samples | 6 | 13 | |
| ** MAII score | log2(6/12*10)=2.32192809488736 effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs). DoF>8 and MAII>0 | log2(13/924*10)=-2.8293812283876 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | |
| Context | PubMed: PLA2G2A [Title/Abstract] AND FBLN1 [Title/Abstract] AND fusion [Title/Abstract] | ||
| Functional or gene categories assigned by FusionGDB annotation | |||
| * DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
| Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Partner | Gene | GO ID | GO term | PubMed ID |
| Hgene | PLA2G2A | GO:0006644 | phospholipid metabolic process | 17069818 |
| Hgene | PLA2G2A | GO:0046473 | phosphatidic acid metabolic process | 9032461 |
| Hgene | PLA2G2A | GO:0070374 | positive regulation of ERK1 and ERK2 cascade | 22837859 |
| Tgene | FBLN1 | GO:0001933 | negative regulation of protein phosphorylation | 11792823 |
| Tgene | FBLN1 | GO:0007162 | negative regulation of cell adhesion | 11792823 |
| Tgene | FBLN1 | GO:0007229 | integrin-mediated signaling pathway | 11792823 |
| Tgene | FBLN1 | GO:0070373 | negative regulation of ERK1 and ERK2 cascade | 11792823 |
| Tgene | FBLN1 | GO:0072378 | blood coagulation, fibrin clot formation | 7642629 |
| Tgene | FBLN1 | GO:1900025 | negative regulation of substrate adhesion-dependent cell spreading | 11792823 |
| Tgene | FBLN1 | GO:2000146 | negative regulation of cell motility | 11792823 |
| Tgene | FBLN1 | GO:2000647 | negative regulation of stem cell proliferation | 11238726 |
| Fusion gene information from three resources (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| TCGA | RV | PRAD | TCGA-KK-A7AQ-01A | PLA2G2A | chr1 | 20301931 | - | FBLN1 | chr22 | 45914462 | + |
| * LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
| Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| intron-intron | ENST00000400520 | ENST00000348697 | PLA2G2A | chr1 | 20301931 | - | FBLN1 | chr22 | 45914462 | + |
| intron-intron | ENST00000400520 | ENST00000402984 | PLA2G2A | chr1 | 20301931 | - | FBLN1 | chr22 | 45914462 | + |
| intron-intron | ENST00000400520 | ENST00000262722 | PLA2G2A | chr1 | 20301931 | - | FBLN1 | chr22 | 45914462 | + |
| intron-intron | ENST00000400520 | ENST00000327858 | PLA2G2A | chr1 | 20301931 | - | FBLN1 | chr22 | 45914462 | + |
| intron-intron | ENST00000400520 | ENST00000442170 | PLA2G2A | chr1 | 20301931 | - | FBLN1 | chr22 | 45914462 | + |
| intron-intron | ENST00000400520 | ENST00000340923 | PLA2G2A | chr1 | 20301931 | - | FBLN1 | chr22 | 45914462 | + |
| intron-intron | ENST00000400520 | ENST00000476366 | PLA2G2A | chr1 | 20301931 | - | FBLN1 | chr22 | 45914462 | + |
| 5CDS-intron | ENST00000496748 | ENST00000348697 | PLA2G2A | chr1 | 20301931 | - | FBLN1 | chr22 | 45914462 | + |
| 5CDS-intron | ENST00000496748 | ENST00000402984 | PLA2G2A | chr1 | 20301931 | - | FBLN1 | chr22 | 45914462 | + |
| 5CDS-intron | ENST00000496748 | ENST00000262722 | PLA2G2A | chr1 | 20301931 | - | FBLN1 | chr22 | 45914462 | + |
| 5CDS-intron | ENST00000496748 | ENST00000327858 | PLA2G2A | chr1 | 20301931 | - | FBLN1 | chr22 | 45914462 | + |
| 5CDS-intron | ENST00000496748 | ENST00000442170 | PLA2G2A | chr1 | 20301931 | - | FBLN1 | chr22 | 45914462 | + |
| 5CDS-intron | ENST00000496748 | ENST00000340923 | PLA2G2A | chr1 | 20301931 | - | FBLN1 | chr22 | 45914462 | + |
| 5CDS-intron | ENST00000496748 | ENST00000476366 | PLA2G2A | chr1 | 20301931 | - | FBLN1 | chr22 | 45914462 | + |
| 5CDS-intron | ENST00000375111 | ENST00000348697 | PLA2G2A | chr1 | 20301931 | - | FBLN1 | chr22 | 45914462 | + |
| 5CDS-intron | ENST00000375111 | ENST00000402984 | PLA2G2A | chr1 | 20301931 | - | FBLN1 | chr22 | 45914462 | + |
| 5CDS-intron | ENST00000375111 | ENST00000262722 | PLA2G2A | chr1 | 20301931 | - | FBLN1 | chr22 | 45914462 | + |
| 5CDS-intron | ENST00000375111 | ENST00000327858 | PLA2G2A | chr1 | 20301931 | - | FBLN1 | chr22 | 45914462 | + |
| 5CDS-intron | ENST00000375111 | ENST00000442170 | PLA2G2A | chr1 | 20301931 | - | FBLN1 | chr22 | 45914462 | + |
| 5CDS-intron | ENST00000375111 | ENST00000340923 | PLA2G2A | chr1 | 20301931 | - | FBLN1 | chr22 | 45914462 | + |
| 5CDS-intron | ENST00000375111 | ENST00000476366 | PLA2G2A | chr1 | 20301931 | - | FBLN1 | chr22 | 45914462 | + |
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FusionProtFeatures for PLA2G2A_FBLN1 |
| Main function of each fusion partner protein. (from UniProt) |
| Hgene | Tgene |
| PLA2G2A | FBLN1 |
| Catalyzes the calcium-dependent hydrolysis of the 2-acylgroups in 3-sn-phosphoglycerides (PubMed:2925633). Thought toparticipate in the regulation of phospholipid metabolism inbiomembranes including eicosanoid biosynthesis. Independent of itscatalytic activity, acts as a ligand for integrins(PubMed:18635536, PubMed:25398877). Binds to and activatesintegrins ITGAV:ITGB3, ITGA4:ITGB1 and ITGA5:ITGB1(PubMed:18635536, PubMed:25398877). Binds to a site (site 2) whichis distinct from the classical ligand-binding site (site 1) andinduces integrin conformational changes and enhanced ligandbinding to site 1 (PubMed:25398877). Induces cell proliferation inan integrin-dependent manner (PubMed:18635536).{ECO:0000269|PubMed:18635536, ECO:0000269|PubMed:25398877,ECO:0000269|PubMed:2925633}. |
| Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at . * Minus value of BPloci means that the break pointn is located before the CDS. |
| - In-frame and retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
| - In-frame and not-retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
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FusionGeneSequence for PLA2G2A_FBLN1 |
| For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. (nt: nucleotides, aa: amino acids) |
| * Fusion amino acid sequences. |
| * Fusion transcript sequences (only coding sequence (CDS) region). |
| * Fusion transcript sequences (Full-length transcript). |
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FusionGenePPI for PLA2G2A_FBLN1 |
| Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in . |
| Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160) |
| Hgene | Hgene's interactors | Tgene | Tgene's interactors |
| PLA2G2A | PLA2G1B, DCN, CEP70, BAG6, PLA2G2A, VIM, UCHL5, UCHL3, USP8, USP7, USP5, USP47, USP4, USP28, USP20, USP2, USP15, UCHL1, SENP6, JOSD2, SENP8, KRAS, ALOX12, ITGAV, ITGB3, TGM2 | FBLN1 | MPG, APP, NID1, ELN, FBLN1, FGB, FN1, NOV, CTGF, CACNA1A, ATN1, GFI1B, SKIL, SMAD4, TCF7L2, ADAMTSL4, TAF9, SMAD3, NOTCH3, PLSCR1, TDGF1, LTBP4, TANK, YWHAQ, NEDD1, APOA1, BHLHE40, ADAMTSL2, EDC4, DKK1, LGALS9, FCN1, PLSCR4, SFRP4, KCTD9, PTPRK, PSG1, PSG3, WNT4, ZFP41, IFI30, NLGN3, DDIAS, OCLN, DEFA1, COLQ, WNT7A, IRF9, PAK7, EFEMP1, ZNF517, NELL1, FAM19A3, PLA2G10, CCDC89, TYW3, AGRP, TRIM25, MCPH1 |
| - Retained PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
| - Lost PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
| - Retained PPIs, but lost function due to frame-shift fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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RelatedDrugs for PLA2G2A_FBLN1 |
| Drugs targeting genes involved in this fusion gene. (DrugBank Version 5.1.0 2018-04-02) |
| Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
| Hgene | PLA2G2A | P14555 | DB00328 | Indomethacin | Phospholipase A2, membrane associated | small molecule | approved|investigational |
| Hgene | PLA2G2A | P14555 | DB02325 | Isopropyl Alcohol | Phospholipase A2, membrane associated | small molecule | approved|investigational |
| Hgene | PLA2G2A | P14555 | DB04786 | Suramin | Phospholipase A2, membrane associated | small molecule | approved|investigational |
| Hgene | PLA2G2A | P14555 | DB01381 | Ginkgo biloba | Phospholipase A2, membrane associated | small molecule | approved|investigational|nutraceutical |
| Hgene | PLA2G2A | P14555 | DB00586 | Diclofenac | Phospholipase A2, membrane associated | small molecule | approved|vet_approved |
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RelatedDiseases for PLA2G2A_FBLN1 |
| Diseases associated with fusion partners. (DisGeNet 4.0) |
| Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
| Hgene | PLA2G2A | C0005586 | Bipolar Disorder | 2 | PSYGENET |
| Hgene | PLA2G2A | C0004153 | Atherosclerosis | 1 | CTD_human |
| Hgene | PLA2G2A | C0011581 | Depressive disorder | 1 | PSYGENET |
| Hgene | PLA2G2A | C0014175 | Endometriosis | 1 | CTD_human |
| Hgene | PLA2G2A | C0035126 | Reperfusion Injury | 1 | CTD_human |
| Hgene | PLA2G2A | C0151744 | Myocardial Ischemia | 1 | CTD_human |
| Hgene | PLA2G2A | C0349218 | Recurrent depressive disorder, unspecified | 1 | PSYGENET |
| Hgene | PLA2G2A | C1839839 | MAJOR AFFECTIVE DISORDER 2 | 1 | PSYGENET |
| Tgene | FBLN1 | C0014175 | Endometriosis | 1 | CTD_human |
| Tgene | FBLN1 | C0033578 | Prostatic Neoplasms | 1 | CTD_human |
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