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Fusion gene ID: 27434 |
FusionGeneSummary for PLA2G2A_CLCN3 |
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Fusion gene information | Fusion gene name: PLA2G2A_CLCN3 | Fusion gene ID: 27434 | Hgene | Tgene | Gene symbol | PLA2G2A | CLCN3 | Gene ID | 5320 | 1182 |
Gene name | phospholipase A2 group IIA | chloride voltage-gated channel 3 | |
Synonyms | MOM1|PLA2|PLA2B|PLA2L|PLA2S|PLAS1|sPLA2 | CLC3|ClC-3 | |
Cytomap | 1p36.13 | 4q33 | |
Type of gene | protein-coding | protein-coding | |
Description | phospholipase A2, membrane associatedGIIC sPLA2NPS-PLA2group IIA phospholipase A2non-pancreatic secretory phospholipase A2phosphatidylcholine 2-acylhydrolase 2Aphospholipase A2, group IIA (platelets, synovial fluid) | H(+)/Cl(-) exchange transporter 3chloride channel 3chloride channel protein 3chloride channel, voltage-sensitive 3chloride transporter ClC-3 | |
Modification date | 20180519 | 20180523 | |
UniProtAcc | P14555 | P51790 | |
Ensembl transtripts involved in fusion gene | ENST00000400520, ENST00000496748, ENST00000375111, | ENST00000513761, ENST00000347613, ENST00000360642, ENST00000504131, ENST00000506924, | |
Fusion gene scores | * DoF score | 6 X 2 X 1=12 | 36 X 4 X 19=2736 |
# samples | 6 | 39 | |
** MAII score | log2(6/12*10)=2.32192809488736 effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs). DoF>8 and MAII>0 | log2(39/2736*10)=-2.81052220113629 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | |
Context | PubMed: PLA2G2A [Title/Abstract] AND CLCN3 [Title/Abstract] AND fusion [Title/Abstract] | ||
Functional or gene categories assigned by FusionGDB annotation |
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
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Partner | Gene | GO ID | GO term | PubMed ID |
Hgene | PLA2G2A | GO:0006644 | phospholipid metabolic process | 17069818 |
Hgene | PLA2G2A | GO:0046473 | phosphatidic acid metabolic process | 9032461 |
Hgene | PLA2G2A | GO:0070374 | positive regulation of ERK1 and ERK2 cascade | 22837859 |
Tgene | CLCN3 | GO:1902476 | chloride transmembrane transport | 11274166 |
![]() (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
TCGA | RV | PRAD | TCGA-EJ-5527-01A | PLA2G2A | chr1 | 20301925 | - | CLCN3 | chr4 | 170623929 | + |
* LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
![]() * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
5CDS-intron | ENST00000400520 | ENST00000513761 | PLA2G2A | chr1 | 20301925 | - | CLCN3 | chr4 | 170623929 | + |
5CDS-intron | ENST00000400520 | ENST00000347613 | PLA2G2A | chr1 | 20301925 | - | CLCN3 | chr4 | 170623929 | + |
5CDS-intron | ENST00000400520 | ENST00000360642 | PLA2G2A | chr1 | 20301925 | - | CLCN3 | chr4 | 170623929 | + |
5CDS-intron | ENST00000400520 | ENST00000504131 | PLA2G2A | chr1 | 20301925 | - | CLCN3 | chr4 | 170623929 | + |
5CDS-intron | ENST00000400520 | ENST00000506924 | PLA2G2A | chr1 | 20301925 | - | CLCN3 | chr4 | 170623929 | + |
5CDS-intron | ENST00000496748 | ENST00000513761 | PLA2G2A | chr1 | 20301925 | - | CLCN3 | chr4 | 170623929 | + |
5CDS-intron | ENST00000496748 | ENST00000347613 | PLA2G2A | chr1 | 20301925 | - | CLCN3 | chr4 | 170623929 | + |
5CDS-intron | ENST00000496748 | ENST00000360642 | PLA2G2A | chr1 | 20301925 | - | CLCN3 | chr4 | 170623929 | + |
5CDS-intron | ENST00000496748 | ENST00000504131 | PLA2G2A | chr1 | 20301925 | - | CLCN3 | chr4 | 170623929 | + |
5CDS-intron | ENST00000496748 | ENST00000506924 | PLA2G2A | chr1 | 20301925 | - | CLCN3 | chr4 | 170623929 | + |
5CDS-intron | ENST00000375111 | ENST00000513761 | PLA2G2A | chr1 | 20301925 | - | CLCN3 | chr4 | 170623929 | + |
5CDS-intron | ENST00000375111 | ENST00000347613 | PLA2G2A | chr1 | 20301925 | - | CLCN3 | chr4 | 170623929 | + |
5CDS-intron | ENST00000375111 | ENST00000360642 | PLA2G2A | chr1 | 20301925 | - | CLCN3 | chr4 | 170623929 | + |
5CDS-intron | ENST00000375111 | ENST00000504131 | PLA2G2A | chr1 | 20301925 | - | CLCN3 | chr4 | 170623929 | + |
5CDS-intron | ENST00000375111 | ENST00000506924 | PLA2G2A | chr1 | 20301925 | - | CLCN3 | chr4 | 170623929 | + |
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FusionProtFeatures for PLA2G2A_CLCN3 |
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Hgene | Tgene |
PLA2G2A | CLCN3 |
Catalyzes the calcium-dependent hydrolysis of the 2-acylgroups in 3-sn-phosphoglycerides (PubMed:2925633). Thought toparticipate in the regulation of phospholipid metabolism inbiomembranes including eicosanoid biosynthesis. Independent of itscatalytic activity, acts as a ligand for integrins(PubMed:18635536, PubMed:25398877). Binds to and activatesintegrins ITGAV:ITGB3, ITGA4:ITGB1 and ITGA5:ITGB1(PubMed:18635536, PubMed:25398877). Binds to a site (site 2) whichis distinct from the classical ligand-binding site (site 1) andinduces integrin conformational changes and enhanced ligandbinding to site 1 (PubMed:25398877). Induces cell proliferation inan integrin-dependent manner (PubMed:18635536).{ECO:0000269|PubMed:18635536, ECO:0000269|PubMed:25398877,ECO:0000269|PubMed:2925633}. | Mediates the exchange of chloride ions against protons.Functions as antiporter and contributes to the acidification ofthe endosome and synaptic vesicle lumen, and may thereby affectvesicle trafficking and exocytosis. May play an important role inneuronal cell function through regulation of membrane excitabilityby protein kinase C. It could help neuronal cells to establishshort-term memory. {ECO:0000269|PubMed:11967229}. |
![]() * Minus value of BPloci means that the break pointn is located before the CDS. |
- In-frame and retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
- In-frame and not-retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
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FusionGeneSequence for PLA2G2A_CLCN3 |
![]() (nt: nucleotides, aa: amino acids) |
* Fusion amino acid sequences. |
* Fusion transcript sequences (only coding sequence (CDS) region). |
* Fusion transcript sequences (Full-length transcript). |
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FusionGenePPI for PLA2G2A_CLCN3 |
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Hgene | Hgene's interactors | Tgene | Tgene's interactors |
PLA2G2A | PLA2G1B, DCN, CEP70, BAG6, PLA2G2A, VIM, UCHL5, UCHL3, USP8, USP7, USP5, USP47, USP4, USP28, USP20, USP2, USP15, UCHL1, SENP6, JOSD2, SENP8, KRAS, ALOX12, ITGAV, ITGB3, TGM2 | CLCN3 | CLCN3, SLC9A3R1, PDZK1, GOPC, CFTR, LGALS3, LGALS8, LGALS9, LYPD3, HSPB1, TMEM9B, GGA1, TPCN2, TRIM25 |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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RelatedDrugs for PLA2G2A_CLCN3 |
![]() (DrugBank Version 5.1.0 2018-04-02) |
Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
Hgene | PLA2G2A | P14555 | DB00328 | Indomethacin | Phospholipase A2, membrane associated | small molecule | approved|investigational |
Hgene | PLA2G2A | P14555 | DB02325 | Isopropyl Alcohol | Phospholipase A2, membrane associated | small molecule | approved|investigational |
Hgene | PLA2G2A | P14555 | DB04786 | Suramin | Phospholipase A2, membrane associated | small molecule | approved|investigational |
Hgene | PLA2G2A | P14555 | DB01381 | Ginkgo biloba | Phospholipase A2, membrane associated | small molecule | approved|investigational|nutraceutical |
Hgene | PLA2G2A | P14555 | DB00586 | Diclofenac | Phospholipase A2, membrane associated | small molecule | approved|vet_approved |
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RelatedDiseases for PLA2G2A_CLCN3 |
![]() (DisGeNet 4.0) |
Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
Hgene | PLA2G2A | C0005586 | Bipolar Disorder | 2 | PSYGENET |
Hgene | PLA2G2A | C0004153 | Atherosclerosis | 1 | CTD_human |
Hgene | PLA2G2A | C0011581 | Depressive disorder | 1 | PSYGENET |
Hgene | PLA2G2A | C0014175 | Endometriosis | 1 | CTD_human |
Hgene | PLA2G2A | C0035126 | Reperfusion Injury | 1 | CTD_human |
Hgene | PLA2G2A | C0151744 | Myocardial Ischemia | 1 | CTD_human |
Hgene | PLA2G2A | C0349218 | Recurrent depressive disorder, unspecified | 1 | PSYGENET |
Hgene | PLA2G2A | C1839839 | MAJOR AFFECTIVE DISORDER 2 | 1 | PSYGENET |
Tgene | CLCN3 | C0017638 | Glioma | 1 | CTD_human |
Tgene | CLCN3 | C0038356 | Stomach Neoplasms | 1 | CTD_human |
Tgene | CLCN3 | C2931822 | Nasopharyngeal carcinoma | 1 | CTD_human |