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Fusion gene ID: 27428 |
FusionGeneSummary for PLA2G15_APBB2 |
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Fusion gene information | Fusion gene name: PLA2G15_APBB2 | Fusion gene ID: 27428 | Hgene | Tgene | Gene symbol | PLA2G15 | APBB2 | Gene ID | 23659 | 323 |
Gene name | phospholipase A2 group XV | amyloid beta precursor protein binding family B member 2 | |
Synonyms | ACS|GXVPLA2|LLPL|LPLA2|LYPLA3 | FE65L|FE65L1 | |
Cytomap | 16q22.1 | 4p14-p13 | |
Type of gene | protein-coding | protein-coding | |
Description | group XV phospholipase A21-O-acylceramide synthaseLCAT-like lysophospholipaselysophospholipase 3 (lysosomal phospholipase A2)lysosomal phospholipase A2 | amyloid-beta A4 precursor protein-binding family B member 2Fe65-like 1protein Fe65-like 1 | |
Modification date | 20180524 | 20180523 | |
UniProtAcc | Q8NCC3 | Q92870 | |
Ensembl transtripts involved in fusion gene | ENST00000413021, ENST00000219345, ENST00000566188, ENST00000444212, ENST00000568599, | ENST00000295974, ENST00000513140, ENST00000508593, ENST00000506352, ENST00000511572, ENST00000543538, ENST00000502841, ENST00000504305, | |
Fusion gene scores | * DoF score | 2 X 2 X 1=4 | 5 X 5 X 6=150 |
# samples | 2 | 8 | |
** MAII score | log2(2/4*10)=2.32192809488736 | log2(8/150*10)=-0.906890595608519 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | |
Context | PubMed: PLA2G15 [Title/Abstract] AND APBB2 [Title/Abstract] AND fusion [Title/Abstract] | ||
Functional or gene categories assigned by FusionGDB annotation |
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
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Partner | Gene | GO ID | GO term | PubMed ID |
Hgene | PLA2G15 | GO:0006650 | glycerophospholipid metabolic process | 20410020 |
Hgene | PLA2G15 | GO:0006672 | ceramide metabolic process | 20410020 |
![]() (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
ChiTaRS3.1 | BQ000365 | PLA2G15 | chr16 | 68294707 | - | APBB2 | chr4 | 41015813 | + |
* LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
![]() * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
intron-3CDS | ENST00000413021 | ENST00000295974 | PLA2G15 | chr16 | 68294707 | - | APBB2 | chr4 | 41015813 | + |
intron-3CDS | ENST00000413021 | ENST00000513140 | PLA2G15 | chr16 | 68294707 | - | APBB2 | chr4 | 41015813 | + |
intron-3CDS | ENST00000413021 | ENST00000508593 | PLA2G15 | chr16 | 68294707 | - | APBB2 | chr4 | 41015813 | + |
intron-3CDS | ENST00000413021 | ENST00000506352 | PLA2G15 | chr16 | 68294707 | - | APBB2 | chr4 | 41015813 | + |
intron-intron | ENST00000413021 | ENST00000511572 | PLA2G15 | chr16 | 68294707 | - | APBB2 | chr4 | 41015813 | + |
intron-intron | ENST00000413021 | ENST00000543538 | PLA2G15 | chr16 | 68294707 | - | APBB2 | chr4 | 41015813 | + |
intron-intron | ENST00000413021 | ENST00000502841 | PLA2G15 | chr16 | 68294707 | - | APBB2 | chr4 | 41015813 | + |
intron-intron | ENST00000413021 | ENST00000504305 | PLA2G15 | chr16 | 68294707 | - | APBB2 | chr4 | 41015813 | + |
3UTR-3CDS | ENST00000219345 | ENST00000295974 | PLA2G15 | chr16 | 68294707 | - | APBB2 | chr4 | 41015813 | + |
3UTR-3CDS | ENST00000219345 | ENST00000513140 | PLA2G15 | chr16 | 68294707 | - | APBB2 | chr4 | 41015813 | + |
3UTR-3CDS | ENST00000219345 | ENST00000508593 | PLA2G15 | chr16 | 68294707 | - | APBB2 | chr4 | 41015813 | + |
3UTR-3CDS | ENST00000219345 | ENST00000506352 | PLA2G15 | chr16 | 68294707 | - | APBB2 | chr4 | 41015813 | + |
3UTR-intron | ENST00000219345 | ENST00000511572 | PLA2G15 | chr16 | 68294707 | - | APBB2 | chr4 | 41015813 | + |
3UTR-intron | ENST00000219345 | ENST00000543538 | PLA2G15 | chr16 | 68294707 | - | APBB2 | chr4 | 41015813 | + |
3UTR-intron | ENST00000219345 | ENST00000502841 | PLA2G15 | chr16 | 68294707 | - | APBB2 | chr4 | 41015813 | + |
3UTR-intron | ENST00000219345 | ENST00000504305 | PLA2G15 | chr16 | 68294707 | - | APBB2 | chr4 | 41015813 | + |
intron-3CDS | ENST00000566188 | ENST00000295974 | PLA2G15 | chr16 | 68294707 | - | APBB2 | chr4 | 41015813 | + |
intron-3CDS | ENST00000566188 | ENST00000513140 | PLA2G15 | chr16 | 68294707 | - | APBB2 | chr4 | 41015813 | + |
intron-3CDS | ENST00000566188 | ENST00000508593 | PLA2G15 | chr16 | 68294707 | - | APBB2 | chr4 | 41015813 | + |
intron-3CDS | ENST00000566188 | ENST00000506352 | PLA2G15 | chr16 | 68294707 | - | APBB2 | chr4 | 41015813 | + |
intron-intron | ENST00000566188 | ENST00000511572 | PLA2G15 | chr16 | 68294707 | - | APBB2 | chr4 | 41015813 | + |
intron-intron | ENST00000566188 | ENST00000543538 | PLA2G15 | chr16 | 68294707 | - | APBB2 | chr4 | 41015813 | + |
intron-intron | ENST00000566188 | ENST00000502841 | PLA2G15 | chr16 | 68294707 | - | APBB2 | chr4 | 41015813 | + |
intron-intron | ENST00000566188 | ENST00000504305 | PLA2G15 | chr16 | 68294707 | - | APBB2 | chr4 | 41015813 | + |
intron-3CDS | ENST00000444212 | ENST00000295974 | PLA2G15 | chr16 | 68294707 | - | APBB2 | chr4 | 41015813 | + |
intron-3CDS | ENST00000444212 | ENST00000513140 | PLA2G15 | chr16 | 68294707 | - | APBB2 | chr4 | 41015813 | + |
intron-3CDS | ENST00000444212 | ENST00000508593 | PLA2G15 | chr16 | 68294707 | - | APBB2 | chr4 | 41015813 | + |
intron-3CDS | ENST00000444212 | ENST00000506352 | PLA2G15 | chr16 | 68294707 | - | APBB2 | chr4 | 41015813 | + |
intron-intron | ENST00000444212 | ENST00000511572 | PLA2G15 | chr16 | 68294707 | - | APBB2 | chr4 | 41015813 | + |
intron-intron | ENST00000444212 | ENST00000543538 | PLA2G15 | chr16 | 68294707 | - | APBB2 | chr4 | 41015813 | + |
intron-intron | ENST00000444212 | ENST00000502841 | PLA2G15 | chr16 | 68294707 | - | APBB2 | chr4 | 41015813 | + |
intron-intron | ENST00000444212 | ENST00000504305 | PLA2G15 | chr16 | 68294707 | - | APBB2 | chr4 | 41015813 | + |
intron-3CDS | ENST00000568599 | ENST00000295974 | PLA2G15 | chr16 | 68294707 | - | APBB2 | chr4 | 41015813 | + |
intron-3CDS | ENST00000568599 | ENST00000513140 | PLA2G15 | chr16 | 68294707 | - | APBB2 | chr4 | 41015813 | + |
intron-3CDS | ENST00000568599 | ENST00000508593 | PLA2G15 | chr16 | 68294707 | - | APBB2 | chr4 | 41015813 | + |
intron-3CDS | ENST00000568599 | ENST00000506352 | PLA2G15 | chr16 | 68294707 | - | APBB2 | chr4 | 41015813 | + |
intron-intron | ENST00000568599 | ENST00000511572 | PLA2G15 | chr16 | 68294707 | - | APBB2 | chr4 | 41015813 | + |
intron-intron | ENST00000568599 | ENST00000543538 | PLA2G15 | chr16 | 68294707 | - | APBB2 | chr4 | 41015813 | + |
intron-intron | ENST00000568599 | ENST00000502841 | PLA2G15 | chr16 | 68294707 | - | APBB2 | chr4 | 41015813 | + |
intron-intron | ENST00000568599 | ENST00000504305 | PLA2G15 | chr16 | 68294707 | - | APBB2 | chr4 | 41015813 | + |
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FusionProtFeatures for PLA2G15_APBB2 |
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Hgene | Tgene |
PLA2G15 | APBB2 |
Has transacylase and calcium-independent phospholipaseA2 activity (PubMed:20410020, PubMed:23958596). Catalyzes theformation of 1-O-acyl-N-acetylsphingosine and the concomitantrelease of a lyso-phospholipid (PubMed:11790796, PubMed:25727495).Has high activity with 1-palmitoyl-2-oleoyl-sn-glycero-3-phosphocholine (POPC) and 1,2-dioleoyl-sn-glycero-3-phosphocholine(DOPC), catalyzing the transfer of oleic acid to N-acetyl-sphingosine. Required for normal phospholipid degradation inalveolar and peritoneal macrophages and in spleen (By similarity).May have weak lysophospholipase activity (PubMed:10092508).{ECO:0000250|UniProtKB:Q8VEB4, ECO:0000269|PubMed:10092508,ECO:0000269|PubMed:11790796, ECO:0000269|PubMed:20410020,ECO:0000269|PubMed:23958596, ECO:0000269|PubMed:25727495}. | May modulate the internalization of amyloid-betaprecursor protein. |
![]() * Minus value of BPloci means that the break pointn is located before the CDS. |
- In-frame and retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
- In-frame and not-retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
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FusionGeneSequence for PLA2G15_APBB2 |
![]() (nt: nucleotides, aa: amino acids) |
* Fusion amino acid sequences. |
* Fusion transcript sequences (only coding sequence (CDS) region). |
* Fusion transcript sequences (Full-length transcript). |
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FusionGenePPI for PLA2G15_APBB2 |
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Hgene | Hgene's interactors | Tgene | Tgene's interactors |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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RelatedDrugs for PLA2G15_APBB2 |
![]() (DrugBank Version 5.1.0 2018-04-02) |
Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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RelatedDiseases for PLA2G15_APBB2 |
![]() (DisGeNet 4.0) |
Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
Tgene | APBB2 | C0043094 | Weight Gain | 1 | CTD_human |