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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 27428

FusionGeneSummary for PLA2G15_APBB2

check button Fusion gene summary
Fusion gene informationFusion gene name: PLA2G15_APBB2
Fusion gene ID: 27428
HgeneTgene
Gene symbol

PLA2G15

APBB2

Gene ID

23659

323

Gene namephospholipase A2 group XVamyloid beta precursor protein binding family B member 2
SynonymsACS|GXVPLA2|LLPL|LPLA2|LYPLA3FE65L|FE65L1
Cytomap

16q22.1

4p14-p13

Type of geneprotein-codingprotein-coding
Descriptiongroup XV phospholipase A21-O-acylceramide synthaseLCAT-like lysophospholipaselysophospholipase 3 (lysosomal phospholipase A2)lysosomal phospholipase A2amyloid-beta A4 precursor protein-binding family B member 2Fe65-like 1protein Fe65-like 1
Modification date2018052420180523
UniProtAcc

Q8NCC3

Q92870

Ensembl transtripts involved in fusion geneENST00000413021, ENST00000219345, 
ENST00000566188, ENST00000444212, 
ENST00000568599, 		ENST00000295974, 
ENST00000513140, ENST00000508593, 
ENST00000506352, ENST00000511572, 
ENST00000543538, ENST00000502841, 
ENST00000504305, 
Fusion gene scores* DoF score2 X 2 X 1=45 X 5 X 6=150
# samples 28
** MAII scorelog2(2/4*10)=2.32192809488736log2(8/150*10)=-0.906890595608519
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: PLA2G15 [Title/Abstract] AND APBB2 [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgenePLA2G15

GO:0006650

glycerophospholipid metabolic process

20410020

HgenePLA2G15

GO:0006672

ceramide metabolic process

20410020


check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChiTaRS3.1BQ000365PLA2G15chr16

68294707

-APBB2chr4

41015813

+
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
intron-3CDSENST00000413021ENST00000295974PLA2G15chr16

68294707

-APBB2chr4

41015813

+
intron-3CDSENST00000413021ENST00000513140PLA2G15chr16

68294707

-APBB2chr4

41015813

+
intron-3CDSENST00000413021ENST00000508593PLA2G15chr16

68294707

-APBB2chr4

41015813

+
intron-3CDSENST00000413021ENST00000506352PLA2G15chr16

68294707

-APBB2chr4

41015813

+
intron-intronENST00000413021ENST00000511572PLA2G15chr16

68294707

-APBB2chr4

41015813

+
intron-intronENST00000413021ENST00000543538PLA2G15chr16

68294707

-APBB2chr4

41015813

+
intron-intronENST00000413021ENST00000502841PLA2G15chr16

68294707

-APBB2chr4

41015813

+
intron-intronENST00000413021ENST00000504305PLA2G15chr16

68294707

-APBB2chr4

41015813

+
3UTR-3CDSENST00000219345ENST00000295974PLA2G15chr16

68294707

-APBB2chr4

41015813

+
3UTR-3CDSENST00000219345ENST00000513140PLA2G15chr16

68294707

-APBB2chr4

41015813

+
3UTR-3CDSENST00000219345ENST00000508593PLA2G15chr16

68294707

-APBB2chr4

41015813

+
3UTR-3CDSENST00000219345ENST00000506352PLA2G15chr16

68294707

-APBB2chr4

41015813

+
3UTR-intronENST00000219345ENST00000511572PLA2G15chr16

68294707

-APBB2chr4

41015813

+
3UTR-intronENST00000219345ENST00000543538PLA2G15chr16

68294707

-APBB2chr4

41015813

+
3UTR-intronENST00000219345ENST00000502841PLA2G15chr16

68294707

-APBB2chr4

41015813

+
3UTR-intronENST00000219345ENST00000504305PLA2G15chr16

68294707

-APBB2chr4

41015813

+
intron-3CDSENST00000566188ENST00000295974PLA2G15chr16

68294707

-APBB2chr4

41015813

+
intron-3CDSENST00000566188ENST00000513140PLA2G15chr16

68294707

-APBB2chr4

41015813

+
intron-3CDSENST00000566188ENST00000508593PLA2G15chr16

68294707

-APBB2chr4

41015813

+
intron-3CDSENST00000566188ENST00000506352PLA2G15chr16

68294707

-APBB2chr4

41015813

+
intron-intronENST00000566188ENST00000511572PLA2G15chr16

68294707

-APBB2chr4

41015813

+
intron-intronENST00000566188ENST00000543538PLA2G15chr16

68294707

-APBB2chr4

41015813

+
intron-intronENST00000566188ENST00000502841PLA2G15chr16

68294707

-APBB2chr4

41015813

+
intron-intronENST00000566188ENST00000504305PLA2G15chr16

68294707

-APBB2chr4

41015813

+
intron-3CDSENST00000444212ENST00000295974PLA2G15chr16

68294707

-APBB2chr4

41015813

+
intron-3CDSENST00000444212ENST00000513140PLA2G15chr16

68294707

-APBB2chr4

41015813

+
intron-3CDSENST00000444212ENST00000508593PLA2G15chr16

68294707

-APBB2chr4

41015813

+
intron-3CDSENST00000444212ENST00000506352PLA2G15chr16

68294707

-APBB2chr4

41015813

+
intron-intronENST00000444212ENST00000511572PLA2G15chr16

68294707

-APBB2chr4

41015813

+
intron-intronENST00000444212ENST00000543538PLA2G15chr16

68294707

-APBB2chr4

41015813

+
intron-intronENST00000444212ENST00000502841PLA2G15chr16

68294707

-APBB2chr4

41015813

+
intron-intronENST00000444212ENST00000504305PLA2G15chr16

68294707

-APBB2chr4

41015813

+
intron-3CDSENST00000568599ENST00000295974PLA2G15chr16

68294707

-APBB2chr4

41015813

+
intron-3CDSENST00000568599ENST00000513140PLA2G15chr16

68294707

-APBB2chr4

41015813

+
intron-3CDSENST00000568599ENST00000508593PLA2G15chr16

68294707

-APBB2chr4

41015813

+
intron-3CDSENST00000568599ENST00000506352PLA2G15chr16

68294707

-APBB2chr4

41015813

+
intron-intronENST00000568599ENST00000511572PLA2G15chr16

68294707

-APBB2chr4

41015813

+
intron-intronENST00000568599ENST00000543538PLA2G15chr16

68294707

-APBB2chr4

41015813

+
intron-intronENST00000568599ENST00000502841PLA2G15chr16

68294707

-APBB2chr4

41015813

+
intron-intronENST00000568599ENST00000504305PLA2G15chr16

68294707

-APBB2chr4

41015813

+

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FusionProtFeatures for PLA2G15_APBB2


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
PLA2G15

Q8NCC3

APBB2

Q92870

Has transacylase and calcium-independent phospholipaseA2 activity (PubMed:20410020, PubMed:23958596). Catalyzes theformation of 1-O-acyl-N-acetylsphingosine and the concomitantrelease of a lyso-phospholipid (PubMed:11790796, PubMed:25727495).Has high activity with 1-palmitoyl-2-oleoyl-sn-glycero-3-phosphocholine (POPC) and 1,2-dioleoyl-sn-glycero-3-phosphocholine(DOPC), catalyzing the transfer of oleic acid to N-acetyl-sphingosine. Required for normal phospholipid degradation inalveolar and peritoneal macrophages and in spleen (By similarity).May have weak lysophospholipase activity (PubMed:10092508).{ECO:0000250|UniProtKB:Q8VEB4, ECO:0000269|PubMed:10092508,ECO:0000269|PubMed:11790796, ECO:0000269|PubMed:20410020,ECO:0000269|PubMed:23958596, ECO:0000269|PubMed:25727495}. May modulate the internalization of amyloid-betaprecursor protein.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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FusionGeneSequence for PLA2G15_APBB2


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for PLA2G15_APBB2


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for PLA2G15_APBB2


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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RelatedDiseases for PLA2G15_APBB2


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
TgeneAPBB2C0043094Weight Gain1CTD_human