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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 27427

FusionGeneSummary for PLA2G12A_SCAPER

check button Fusion gene summary
Fusion gene informationFusion gene name: PLA2G12A_SCAPER
Fusion gene ID: 27427
HgeneTgene
Gene symbol

PLA2G12A

SCAPER

Gene ID

81579

49855

Gene namephospholipase A2 group XIIAS-phase cyclin A associated protein in the ER
SynonymsGXII|PLA2G12|ROSSYMSTP063|ZNF291|Zfp291
Cytomap

4q25

15q24.3

Type of geneprotein-codingprotein-coding
Descriptiongroup XIIA secretory phospholipase A2GXII sPLA2group XII secreted phospholipase A2group XIIA secreted phospholipase A2phosphatidylcholine 2-acylhydrolase 12Aphospholipase A2, group XIIsPLA2-XIIS phase cyclin A-associated protein in the endoplasmic reticulumzinc finger protein 291
Modification date2018051920180519
UniProtAcc

Q9BZM1

Q9BY12

Ensembl transtripts involved in fusion geneENST00000243501, ENST00000502283, 
ENST00000502772, 
ENST00000538941, 
ENST00000563290, ENST00000324767, 
ENST00000562890, 
Fusion gene scores* DoF score2 X 2 X 2=86 X 6 X 3=108
# samples 26
** MAII scorelog2(2/8*10)=1.32192809488736log2(6/108*10)=-0.84799690655495
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: PLA2G12A [Title/Abstract] AND SCAPER [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID

check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChiTaRS3.1DA268556PLA2G12Achr4

110650757

-SCAPERchr15

76914171

-
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
Frame-shiftENST00000243501ENST00000538941PLA2G12Achr4

110650757

-SCAPERchr15

76914171

-
Frame-shiftENST00000243501ENST00000563290PLA2G12Achr4

110650757

-SCAPERchr15

76914171

-
Frame-shiftENST00000243501ENST00000324767PLA2G12Achr4

110650757

-SCAPERchr15

76914171

-
5CDS-intronENST00000243501ENST00000562890PLA2G12Achr4

110650757

-SCAPERchr15

76914171

-
Frame-shiftENST00000502283ENST00000538941PLA2G12Achr4

110650757

-SCAPERchr15

76914171

-
Frame-shiftENST00000502283ENST00000563290PLA2G12Achr4

110650757

-SCAPERchr15

76914171

-
Frame-shiftENST00000502283ENST00000324767PLA2G12Achr4

110650757

-SCAPERchr15

76914171

-
5CDS-intronENST00000502283ENST00000562890PLA2G12Achr4

110650757

-SCAPERchr15

76914171

-
intron-3CDSENST00000502772ENST00000538941PLA2G12Achr4

110650757

-SCAPERchr15

76914171

-
intron-3CDSENST00000502772ENST00000563290PLA2G12Achr4

110650757

-SCAPERchr15

76914171

-
intron-3CDSENST00000502772ENST00000324767PLA2G12Achr4

110650757

-SCAPERchr15

76914171

-
intron-intronENST00000502772ENST00000562890PLA2G12Achr4

110650757

-SCAPERchr15

76914171

-

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FusionProtFeatures for PLA2G12A_SCAPER


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
PLA2G12A

Q9BZM1

SCAPER

Q9BY12

PA2 catalyzes the calcium-dependent hydrolysis of the 2-acyl groups in 3-sn-phosphoglycerides. Does not exhibit detectableactivity toward sn-2-arachidonoyl- or linoleoyl-phosphatidylcholine or -phosphatidylethanolamine.{ECO:0000269|PubMed:12522102}. CCNA2/CDK2 regulatory protein that transiently maintainsCCNA2 in the cytoplasm. {ECO:0000269|PubMed:17698606}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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FusionGeneSequence for PLA2G12A_SCAPER


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for PLA2G12A_SCAPER


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors
PLA2G12ARPS6, UCK1, RB1, UMPS, RPS15, YWHAG, TMEM37, DVL2, MEF2C, EPB41L3, PXDN, TRIM25SCAPERCALM1, HECW2, CCNA2, APPL1, MZT1


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for PLA2G12A_SCAPER


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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RelatedDiseases for PLA2G12A_SCAPER


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
HgenePLA2G12AC0023893Liver Cirrhosis, Experimental1CTD_human
TgeneSCAPERC3714756Intellectual Disability1CTD_human