![]() |
||||||
|
![]() | |
![]() | |
![]() | |
![]() | |
![]() | |
![]() |
Fusion gene ID: 27427 |
FusionGeneSummary for PLA2G12A_SCAPER |
![]() |
Fusion gene information | Fusion gene name: PLA2G12A_SCAPER | Fusion gene ID: 27427 | Hgene | Tgene | Gene symbol | PLA2G12A | SCAPER | Gene ID | 81579 | 49855 |
Gene name | phospholipase A2 group XIIA | S-phase cyclin A associated protein in the ER | |
Synonyms | GXII|PLA2G12|ROSSY | MSTP063|ZNF291|Zfp291 | |
Cytomap | 4q25 | 15q24.3 | |
Type of gene | protein-coding | protein-coding | |
Description | group XIIA secretory phospholipase A2GXII sPLA2group XII secreted phospholipase A2group XIIA secreted phospholipase A2phosphatidylcholine 2-acylhydrolase 12Aphospholipase A2, group XIIsPLA2-XII | S phase cyclin A-associated protein in the endoplasmic reticulumzinc finger protein 291 | |
Modification date | 20180519 | 20180519 | |
UniProtAcc | Q9BZM1 | Q9BY12 | |
Ensembl transtripts involved in fusion gene | ENST00000243501, ENST00000502283, ENST00000502772, | ENST00000538941, ENST00000563290, ENST00000324767, ENST00000562890, | |
Fusion gene scores | * DoF score | 2 X 2 X 2=8 | 6 X 6 X 3=108 |
# samples | 2 | 6 | |
** MAII score | log2(2/8*10)=1.32192809488736 | log2(6/108*10)=-0.84799690655495 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | |
Context | PubMed: PLA2G12A [Title/Abstract] AND SCAPER [Title/Abstract] AND fusion [Title/Abstract] | ||
Functional or gene categories assigned by FusionGDB annotation |
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
![]() |
Partner | Gene | GO ID | GO term | PubMed ID |
![]() (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
ChiTaRS3.1 | DA268556 | PLA2G12A | chr4 | 110650757 | - | SCAPER | chr15 | 76914171 | - |
* LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
![]() * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
Frame-shift | ENST00000243501 | ENST00000538941 | PLA2G12A | chr4 | 110650757 | - | SCAPER | chr15 | 76914171 | - |
Frame-shift | ENST00000243501 | ENST00000563290 | PLA2G12A | chr4 | 110650757 | - | SCAPER | chr15 | 76914171 | - |
Frame-shift | ENST00000243501 | ENST00000324767 | PLA2G12A | chr4 | 110650757 | - | SCAPER | chr15 | 76914171 | - |
5CDS-intron | ENST00000243501 | ENST00000562890 | PLA2G12A | chr4 | 110650757 | - | SCAPER | chr15 | 76914171 | - |
Frame-shift | ENST00000502283 | ENST00000538941 | PLA2G12A | chr4 | 110650757 | - | SCAPER | chr15 | 76914171 | - |
Frame-shift | ENST00000502283 | ENST00000563290 | PLA2G12A | chr4 | 110650757 | - | SCAPER | chr15 | 76914171 | - |
Frame-shift | ENST00000502283 | ENST00000324767 | PLA2G12A | chr4 | 110650757 | - | SCAPER | chr15 | 76914171 | - |
5CDS-intron | ENST00000502283 | ENST00000562890 | PLA2G12A | chr4 | 110650757 | - | SCAPER | chr15 | 76914171 | - |
intron-3CDS | ENST00000502772 | ENST00000538941 | PLA2G12A | chr4 | 110650757 | - | SCAPER | chr15 | 76914171 | - |
intron-3CDS | ENST00000502772 | ENST00000563290 | PLA2G12A | chr4 | 110650757 | - | SCAPER | chr15 | 76914171 | - |
intron-3CDS | ENST00000502772 | ENST00000324767 | PLA2G12A | chr4 | 110650757 | - | SCAPER | chr15 | 76914171 | - |
intron-intron | ENST00000502772 | ENST00000562890 | PLA2G12A | chr4 | 110650757 | - | SCAPER | chr15 | 76914171 | - |
Top |
FusionProtFeatures for PLA2G12A_SCAPER |
![]() |
Hgene | Tgene |
PLA2G12A | SCAPER |
PA2 catalyzes the calcium-dependent hydrolysis of the 2-acyl groups in 3-sn-phosphoglycerides. Does not exhibit detectableactivity toward sn-2-arachidonoyl- or linoleoyl-phosphatidylcholine or -phosphatidylethanolamine.{ECO:0000269|PubMed:12522102}. | CCNA2/CDK2 regulatory protein that transiently maintainsCCNA2 in the cytoplasm. {ECO:0000269|PubMed:17698606}. |
![]() * Minus value of BPloci means that the break pointn is located before the CDS. |
- In-frame and retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
- In-frame and not-retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
Top |
FusionGeneSequence for PLA2G12A_SCAPER |
![]() (nt: nucleotides, aa: amino acids) |
* Fusion amino acid sequences. |
* Fusion transcript sequences (only coding sequence (CDS) region). |
* Fusion transcript sequences (Full-length transcript). |
Top |
FusionGenePPI for PLA2G12A_SCAPER |
![]() |
![]() |
Hgene | Hgene's interactors | Tgene | Tgene's interactors |
PLA2G12A | RPS6, UCK1, RB1, UMPS, RPS15, YWHAG, TMEM37, DVL2, MEF2C, EPB41L3, PXDN, TRIM25 | SCAPER | CALM1, HECW2, CCNA2, APPL1, MZT1 |
![]() |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
![]() |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
![]() |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
Top |
RelatedDrugs for PLA2G12A_SCAPER |
![]() (DrugBank Version 5.1.0 2018-04-02) |
Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
Top |
RelatedDiseases for PLA2G12A_SCAPER |
![]() (DisGeNet 4.0) |
Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
Hgene | PLA2G12A | C0023893 | Liver Cirrhosis, Experimental | 1 | CTD_human |
Tgene | SCAPER | C3714756 | Intellectual Disability | 1 | CTD_human |