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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 27399

FusionGeneSummary for PKN2_VAV3

check button Fusion gene summary
Fusion gene informationFusion gene name: PKN2_VAV3
Fusion gene ID: 27399
HgeneTgene
Gene symbol

PKN2

VAV3

Gene ID

5586

10451

Gene nameprotein kinase N2vav guanine nucleotide exchange factor 3
SynonymsPAK2|PRK2|PRKCL2|PRO2042|Pak-2|STK7-
Cytomap

1p22.2

1p13.3

Type of geneprotein-codingprotein-coding
Descriptionserine/threonine-protein kinase N2PKN gammacardiolipin-activated protein kinase Pak2protein kinase C-like 2protein-kinase C-related kinase 2guanine nucleotide exchange factor VAV3VAV-3vav 3 guanine nucleotide exchange factorvav 3 oncogene
Modification date2018052320180519
UniProtAcc

Q16513

Q9UKW4

Ensembl transtripts involved in fusion geneENST00000316005, ENST00000370521, 
ENST00000370505, ENST00000370513, 
ENST00000544045, ENST00000495119, 
ENST00000370056, ENST00000527011, 
ENST00000544443, ENST00000415432, 
ENST00000343258, ENST00000371846, 
Fusion gene scores* DoF score4 X 4 X 2=324 X 5 X 2=40
# samples 55
** MAII scorelog2(5/32*10)=0.643856189774725
effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs).
DoF>8 and MAII>0		log2(5/40*10)=0.321928094887362
effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs).
DoF>8 and MAII>0
Context

PubMed: PKN2 [Title/Abstract] AND VAV3 [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgenePKN2

GO:0006468

protein phosphorylation

17332740

HgenePKN2

GO:0010631

epithelial cell migration

21754995


check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
TCGALDBRCATCGA-E9-A22B-01APKN2chr1

89279416

+VAV3chr1

108212094

-
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
intron-intronENST00000316005ENST00000370056PKN2chr1

89279416

+VAV3chr1

108212094

-
intron-intronENST00000316005ENST00000527011PKN2chr1

89279416

+VAV3chr1

108212094

-
intron-intronENST00000316005ENST00000544443PKN2chr1

89279416

+VAV3chr1

108212094

-
intron-intronENST00000316005ENST00000415432PKN2chr1

89279416

+VAV3chr1

108212094

-
intron-intronENST00000316005ENST00000343258PKN2chr1

89279416

+VAV3chr1

108212094

-
intron-intronENST00000316005ENST00000371846PKN2chr1

89279416

+VAV3chr1

108212094

-
5CDS-intronENST00000370521ENST00000370056PKN2chr1

89279416

+VAV3chr1

108212094

-
5CDS-intronENST00000370521ENST00000527011PKN2chr1

89279416

+VAV3chr1

108212094

-
5CDS-intronENST00000370521ENST00000544443PKN2chr1

89279416

+VAV3chr1

108212094

-
5CDS-intronENST00000370521ENST00000415432PKN2chr1

89279416

+VAV3chr1

108212094

-
5CDS-intronENST00000370521ENST00000343258PKN2chr1

89279416

+VAV3chr1

108212094

-
5CDS-intronENST00000370521ENST00000371846PKN2chr1

89279416

+VAV3chr1

108212094

-
5CDS-intronENST00000370505ENST00000370056PKN2chr1

89279416

+VAV3chr1

108212094

-
5CDS-intronENST00000370505ENST00000527011PKN2chr1

89279416

+VAV3chr1

108212094

-
5CDS-intronENST00000370505ENST00000544443PKN2chr1

89279416

+VAV3chr1

108212094

-
5CDS-intronENST00000370505ENST00000415432PKN2chr1

89279416

+VAV3chr1

108212094

-
5CDS-intronENST00000370505ENST00000343258PKN2chr1

89279416

+VAV3chr1

108212094

-
5CDS-intronENST00000370505ENST00000371846PKN2chr1

89279416

+VAV3chr1

108212094

-
5CDS-intronENST00000370513ENST00000370056PKN2chr1

89279416

+VAV3chr1

108212094

-
5CDS-intronENST00000370513ENST00000527011PKN2chr1

89279416

+VAV3chr1

108212094

-
5CDS-intronENST00000370513ENST00000544443PKN2chr1

89279416

+VAV3chr1

108212094

-
5CDS-intronENST00000370513ENST00000415432PKN2chr1

89279416

+VAV3chr1

108212094

-
5CDS-intronENST00000370513ENST00000343258PKN2chr1

89279416

+VAV3chr1

108212094

-
5CDS-intronENST00000370513ENST00000371846PKN2chr1

89279416

+VAV3chr1

108212094

-
5CDS-intronENST00000544045ENST00000370056PKN2chr1

89279416

+VAV3chr1

108212094

-
5CDS-intronENST00000544045ENST00000527011PKN2chr1

89279416

+VAV3chr1

108212094

-
5CDS-intronENST00000544045ENST00000544443PKN2chr1

89279416

+VAV3chr1

108212094

-
5CDS-intronENST00000544045ENST00000415432PKN2chr1

89279416

+VAV3chr1

108212094

-
5CDS-intronENST00000544045ENST00000343258PKN2chr1

89279416

+VAV3chr1

108212094

-
5CDS-intronENST00000544045ENST00000371846PKN2chr1

89279416

+VAV3chr1

108212094

-
intron-intronENST00000495119ENST00000370056PKN2chr1

89279416

+VAV3chr1

108212094

-
intron-intronENST00000495119ENST00000527011PKN2chr1

89279416

+VAV3chr1

108212094

-
intron-intronENST00000495119ENST00000544443PKN2chr1

89279416

+VAV3chr1

108212094

-
intron-intronENST00000495119ENST00000415432PKN2chr1

89279416

+VAV3chr1

108212094

-
intron-intronENST00000495119ENST00000343258PKN2chr1

89279416

+VAV3chr1

108212094

-
intron-intronENST00000495119ENST00000371846PKN2chr1

89279416

+VAV3chr1

108212094

-

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FusionProtFeatures for PKN2_VAV3


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
PKN2

Q16513

VAV3

Q9UKW4

PKC-related serine/threonine-protein kinase and Rho/Raceffector protein that participates in specific signal transductionresponses in the cell. Plays a role in the regulation of cellcycle progression, actin cytoskeleton assembly, cell migration,cell adhesion, tumor cell invasion and transcription activationsignaling processes. Phosphorylates CTTN in hyaluronan-inducedastrocytes and hence decreases CTTN ability to associate withfilamentous actin. Phosphorylates HDAC5, therefore lead to impairHDAC5 import. Direct RhoA target required for the regulation ofthe maturation of primordial junctions into apical junctionformation in bronchial epithelial cells. Required for G2/M phasesof the cell cycle progression and abscission during cytokinesis ina ECT2-dependent manner. Stimulates FYN kinase activity that isrequired for establishment of skin cell-cell adhesion duringkeratinocytes differentiation. Regulates epithelial bladder cellsspeed and direction of movement during cell migration and tumorcell invasion. Inhibits Akt pro-survival-induced kinase activity.Mediates Rho protein-induced transcriptional activation via the c-fos serum response factor (SRF). Phosphorylates HCV NS5B leadingto stimulation of HCV RNA replication. Involved in the negativeregulation of ciliogenesis (PubMed:27104747).{ECO:0000269|PubMed:10226025, ECO:0000269|PubMed:10926925,ECO:0000269|PubMed:11777936, ECO:0000269|PubMed:11781095,ECO:0000269|PubMed:15364941, ECO:0000269|PubMed:17332740,ECO:0000269|PubMed:20188095, ECO:0000269|PubMed:20974804,ECO:0000269|PubMed:21754995, ECO:0000269|PubMed:27104747,ECO:0000269|PubMed:9121475}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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FusionGeneSequence for PKN2_VAV3


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for PKN2_VAV3


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors
PKN2PTPN13, NCK1, PLCG1, RHOA, PDPK1, PDK1, AKT1, NCK2, PKN2, USP11, WDR20, HDAC5, PTEN, CCDC136, CHGB, MYO9B, FAM193B, EIF3G, EEF1A1, NEDD4, CEBPA, ELAVL1, VCP, HSP90AA1, HECW2, FRMPD2, TGFBR2, SKAP1, THBS3, CYP1A1, UNK, ACBD3, LSM2, LSM3, LSM4, LSM6, LSM7, CCT6A, PPM1B, RPE, PCM1, CEP162, CEP128, CEP44, CEP19, CETN2, CENPJ, ATP2A2, BTF3, DARS, EEF1D, EEF1G, EPRS, IARS, KARS, KTN1, MARS, RUFY1, RARS, SOAT1, VARS, SGPL1, VAPB, EEF1E1, ERLIN1, CKAP4, TRAM1, LARS, WDR74, MBOAT7, TRMT1L, TMUB1, RABL3, SNW1, CDC5L, AHSA1, CDH1, CETN1, CAMKV, GOPC, ZNF785, DFFB, DEF8, HAVCR2, PPIAL4G, LGALS7VAV3GRB2, PDGFRB, EGFR, RAC1, RHOA, RHOG, ROS1, INSR, IGF1R, SHC1, BLNK, ESR1, ERBB2, ERBB3, TRAF6, TNFRSF11A, TRAF1, TRAF3


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for PKN2_VAV3


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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RelatedDiseases for PKN2_VAV3


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
TgeneVAV3C0017661IGA Glomerulonephritis1CTD_human
TgeneVAV3C0020538Hypertensive disease1CTD_human
TgeneVAV3C0020578Hyperventilation1CTD_human
TgeneVAV3C0033578Prostatic Neoplasms1CTD_human
TgeneVAV3C0039231Tachycardia1CTD_human