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Fusion gene ID: 27392 |
FusionGeneSummary for PKN1_ANXA4 |
 Fusion gene summary |
| Fusion gene information | Fusion gene name: PKN1_ANXA4 | Fusion gene ID: 27392 | Hgene | Tgene | Gene symbol | PKN1 | ANXA4 | Gene ID | 5585 | 307 |
| Gene name | protein kinase N1 | annexin A4 | |
| Synonyms | DBK|PAK-1|PAK1|PKN|PKN-ALPHA|PRK1|PRKCL1 | ANX4|HEL-S-274|P32.5|PAP-II|PIG28|PP4-X|ZAP36 | |
| Cytomap | 19p13.12 | 2p13.3 | |
| Type of gene | protein-coding | protein-coding | |
| Description | serine/threonine-protein kinase N1protease-activated kinase 1protein kinase C-like 1protein kinase C-like PKNprotein kinase C-related kinase 1protein kinase PKN-alphaserine-threonine kinase Nserine/threonine protein kinase N | annexin A435-beta calcimedinannexin IV (placental anticoagulant protein II)annexin-4carbohydrate-binding protein p33/p41chromobindin-4endonexin Iepididymis secretory protein Li 274lipocortin IVplacental anticoagulant protein IIproliferation-indu | |
| Modification date | 20180523 | 20180519 | |
| UniProtAcc | Q16512 | P09525 | |
| Ensembl transtripts involved in fusion gene | ENST00000242783, ENST00000587429, ENST00000342216, | ENST00000418066, ENST00000409920, ENST00000394295, ENST00000536030, | |
| Fusion gene scores | * DoF score | 4 X 4 X 4=64 | 8 X 3 X 7=168 |
| # samples | 4 | 10 | |
| ** MAII score | log2(4/64*10)=-0.678071905112638 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | log2(10/168*10)=-0.748461233004036 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | |
| Context | PubMed: PKN1 [Title/Abstract] AND ANXA4 [Title/Abstract] AND fusion [Title/Abstract] | ||
| Functional or gene categories assigned by FusionGDB annotation | |||
| * DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
| Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Partner | Gene | GO ID | GO term | PubMed ID |
| Hgene | PKN1 | GO:0006357 | regulation of transcription by RNA polymerase II | 12514133 |
| Hgene | PKN1 | GO:0006468 | protein phosphorylation | 17332740 |
| Hgene | PKN1 | GO:0035407 | histone H3-T11 phosphorylation | 18066052 |
| Tgene | ANXA4 | GO:0006357 | regulation of transcription by RNA polymerase II | 20237821 |
| Tgene | ANXA4 | GO:0032088 | negative regulation of NF-kappaB transcription factor activity | 20237821 |
| Fusion gene information from three resources (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| TCGA | RV | LIHC | TCGA-BC-4072-01B | PKN1 | chr19 | 14574965 | + | ANXA4 | chr2 | 70015186 | + |
| * LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
| Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| 5CDS-intron | ENST00000242783 | ENST00000418066 | PKN1 | chr19 | 14574965 | + | ANXA4 | chr2 | 70015186 | + |
| 5CDS-intron | ENST00000242783 | ENST00000409920 | PKN1 | chr19 | 14574965 | + | ANXA4 | chr2 | 70015186 | + |
| 5CDS-intron | ENST00000242783 | ENST00000394295 | PKN1 | chr19 | 14574965 | + | ANXA4 | chr2 | 70015186 | + |
| 5CDS-intron | ENST00000242783 | ENST00000536030 | PKN1 | chr19 | 14574965 | + | ANXA4 | chr2 | 70015186 | + |
| intron-intron | ENST00000587429 | ENST00000418066 | PKN1 | chr19 | 14574965 | + | ANXA4 | chr2 | 70015186 | + |
| intron-intron | ENST00000587429 | ENST00000409920 | PKN1 | chr19 | 14574965 | + | ANXA4 | chr2 | 70015186 | + |
| intron-intron | ENST00000587429 | ENST00000394295 | PKN1 | chr19 | 14574965 | + | ANXA4 | chr2 | 70015186 | + |
| intron-intron | ENST00000587429 | ENST00000536030 | PKN1 | chr19 | 14574965 | + | ANXA4 | chr2 | 70015186 | + |
| 5CDS-intron | ENST00000342216 | ENST00000418066 | PKN1 | chr19 | 14574965 | + | ANXA4 | chr2 | 70015186 | + |
| 5CDS-intron | ENST00000342216 | ENST00000409920 | PKN1 | chr19 | 14574965 | + | ANXA4 | chr2 | 70015186 | + |
| 5CDS-intron | ENST00000342216 | ENST00000394295 | PKN1 | chr19 | 14574965 | + | ANXA4 | chr2 | 70015186 | + |
| 5CDS-intron | ENST00000342216 | ENST00000536030 | PKN1 | chr19 | 14574965 | + | ANXA4 | chr2 | 70015186 | + |
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FusionProtFeatures for PKN1_ANXA4 |
| Main function of each fusion partner protein. (from UniProt) |
| Hgene | Tgene |
| PKN1 | ANXA4 |
| PKC-related serine/threonine-protein kinase involved invarious processes such as regulation of the intermediate filamentsof the actin cytoskeleton, cell migration, tumor cell invasion andtranscription regulation. Part of a signaling cascade that beginswith the activation of the adrenergic receptor ADRA1B and leads tothe activation of MAPK14. Regulates the cytoskeletal network byphosphorylating proteins such as VIM and neurofilament proteinsNEFH, NEFL and NEFM, leading to inhibit their polymerization.Phosphorylates 'Ser-575', 'Ser-637' and 'Ser-669' of MAPT/Tau,lowering its ability to bind to microtubules, resulting indisruption of tubulin assembly. Acts as a key coactivator ofandrogen receptor (ANDR)-dependent transcription, by beingrecruited to ANDR target genes and specifically mediatingphosphorylation of 'Thr-11' of histone H3 (H3T11ph), a specifictag for epigenetic transcriptional activation that promotesdemethylation of histone H3 'Lys-9' (H3K9me) by KDM4C/JMJD2C.Phosphorylates HDAC5, HDAC7 and HDAC9, leading to impair theirimport in the nucleus. Phosphorylates 'Thr-38' of PPP1R14A, 'Ser-159', 'Ser-163' and 'Ser-170' of MARCKS, and GFAP. Able tophosphorylate RPS6 in vitro. {ECO:0000269|PubMed:11104762,ECO:0000269|PubMed:12514133, ECO:0000269|PubMed:17332740,ECO:0000269|PubMed:18066052, ECO:0000269|PubMed:20188095,ECO:0000269|PubMed:21224381, ECO:0000269|PubMed:21754995,ECO:0000269|PubMed:24248594, ECO:0000269|PubMed:8557118,ECO:0000269|PubMed:8621664, ECO:0000269|PubMed:9175763}. | Calcium/phospholipid-binding protein which promotesmembrane fusion and is involved in exocytosis. {ECO:0000250}. |
| Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at . * Minus value of BPloci means that the break pointn is located before the CDS. |
| - In-frame and retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
| - In-frame and not-retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
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FusionGeneSequence for PKN1_ANXA4 |
| For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. (nt: nucleotides, aa: amino acids) |
| * Fusion amino acid sequences. |
| * Fusion transcript sequences (only coding sequence (CDS) region). |
| * Fusion transcript sequences (Full-length transcript). |
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FusionGenePPI for PKN1_ANXA4 |
| Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in . |
| Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160) |
| Hgene | Hgene's interactors | Tgene | Tgene's interactors |
| PKN1 | CCDC85B, RHOA, NEFL, NEFH, ACTN1, PLD1, VIM, PDK1, NEUROD2, AKAP9, PDPK1, CDR2, HDAC5, HDAC6, HIST2H3C, ZNF282, SPRR2D, TUBA1A, TUBB, MYC, TRAF2, PKN1, MAPK9, TOM1L1, CCNT2, CASP3, MAPT, TRAF1, TNFRSF1B, MAPK12, MAPK11, MAP2K3, MAP2K6, HSP90AA1, MARCKS, CD81, CDC25C, MBP, WBSCR22, TBXA2R, HIST1H1A, PA2G4, GOLGA2, KRT15, KRT31, MID1, HOMER3, SSX2IP, CEP57L1, WDR5, KMT2A, RBBP5, ASH2L, MAGEA10, PLAUR, C1orf186, PPM1A, PPM1G, NTRK1, KBTBD8, COG6, AEN, FUOM | ANXA4 | NFKB1, H2AFX, UCHL5, SMPD1, NMT2, TINF2, POT1, DNAJB11, ANXA7, MPST, ANXA3, ANXA1, PADI4, EZH2, RAB8A, RHOU, CDH1, SF3A3 |
| - Retained PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
| - Lost PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
| - Retained PPIs, but lost function due to frame-shift fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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RelatedDrugs for PKN1_ANXA4 |
| Drugs targeting genes involved in this fusion gene. (DrugBank Version 5.1.0 2018-04-02) |
| Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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RelatedDiseases for PKN1_ANXA4 |
| Diseases associated with fusion partners. (DisGeNet 4.0) |
| Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
| Tgene | ANXA4 | C0007134 | Renal Cell Carcinoma | 1 | CTD_human |
| Tgene | ANXA4 | C0023467 | Leukemia, Myelocytic, Acute | 1 | CTD_human |
| Tgene | ANXA4 | C0023893 | Liver Cirrhosis, Experimental | 1 | CTD_human |
| Tgene | ANXA4 | C0023903 | Liver neoplasms | 1 | CTD_human |
| Tgene | ANXA4 | C0024667 | Animal Mammary Neoplasms | 1 | CTD_human |
| Tgene | ANXA4 | C0024668 | Mammary Neoplasms, Experimental | 1 | CTD_human |
| Tgene | ANXA4 | C0027627 | Neoplasm Metastasis | 1 | CTD_human |
| Tgene | ANXA4 | C0032927 | Precancerous Conditions | 1 | CTD_human |
| Tgene | ANXA4 | C0033578 | Prostatic Neoplasms | 1 | CTD_human |
| Tgene | ANXA4 | C2239176 | Liver carcinoma | 1 | CTD_human |
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