FusionGDB Logo

Home

Download

Statistics

Examples

Help

Contact

Center for Computational Systems Medicine
leaf

FusionGeneSummary

leaf

FusionProtFeature

leaf

FusionGeneSequence

leaf

FusionGenePPI

leaf

RelatedDrugs

leaf

RelatedDiseases

Fusion gene ID: 27390

FusionGeneSummary for PKM_TUSC3

check button Fusion gene summary
Fusion gene informationFusion gene name: PKM_TUSC3
Fusion gene ID: 27390
HgeneTgene
Gene symbol

PKM

TUSC3

Gene ID

5315

7991

Gene namepyruvate kinase M1/2tumor suppressor candidate 3
SynonymsCTHBP|HEL-S-30|OIP3|PK3|PKM2|TCB|THBP1D8S1992|M33|MRT22|MRT7|MagT2|N33|OST3A
Cytomap

15q23

8p22

Type of geneprotein-codingprotein-coding
Descriptionpyruvate kinase PKMOIP-3OPA-interacting protein 3PK, muscle typecytosolic thyroid hormone-binding proteinepididymis secretory protein Li 30p58pyruvate kinase 2/3pyruvate kinase isozymes M1/M2pyruvate kinase muscle isozymepyruvate kinase, muscletumor suppressor candidate 3magnesium uptake/transporter TUSC3oligosaccharyltransferase 3 homolog Aputative prostate cancer tumor suppressor
Modification date2018052720180523
UniProtAcc

P14618

Q13454

Ensembl transtripts involved in fusion geneENST00000319622, ENST00000565184, 
ENST00000389093, ENST00000335181, 
ENST00000568883, ENST00000449901, 
ENST00000565154, ENST00000568459, 
ENST00000503191, ENST00000382020, 
ENST00000506802, ENST00000509380, 
ENST00000503731, 
Fusion gene scores* DoF score17 X 21 X 3=10714 X 4 X 2=32
# samples 214
** MAII scorelog2(21/1071*10)=-2.35049724708413
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
log2(4/32*10)=0.321928094887362
effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs).
DoF>8 and MAII>0
Context

PubMed: PKM [Title/Abstract] AND TUSC3 [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgenePKM

GO:0012501

programmed cell death

17308100


check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChiTaRS3.1BF204709PKMchr15

72523241

+TUSC3chr8

15397794

+
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
5UTR-intronENST00000319622ENST00000503191PKMchr15

72523241

+TUSC3chr8

15397794

+
5UTR-5UTRENST00000319622ENST00000382020PKMchr15

72523241

+TUSC3chr8

15397794

+
5UTR-5UTRENST00000319622ENST00000506802PKMchr15

72523241

+TUSC3chr8

15397794

+
5UTR-5UTRENST00000319622ENST00000509380PKMchr15

72523241

+TUSC3chr8

15397794

+
5UTR-5UTRENST00000319622ENST00000503731PKMchr15

72523241

+TUSC3chr8

15397794

+
5UTR-intronENST00000565184ENST00000503191PKMchr15

72523241

+TUSC3chr8

15397794

+
5UTR-5UTRENST00000565184ENST00000382020PKMchr15

72523241

+TUSC3chr8

15397794

+
5UTR-5UTRENST00000565184ENST00000506802PKMchr15

72523241

+TUSC3chr8

15397794

+
5UTR-5UTRENST00000565184ENST00000509380PKMchr15

72523241

+TUSC3chr8

15397794

+
5UTR-5UTRENST00000565184ENST00000503731PKMchr15

72523241

+TUSC3chr8

15397794

+
intron-intronENST00000389093ENST00000503191PKMchr15

72523241

+TUSC3chr8

15397794

+
intron-5UTRENST00000389093ENST00000382020PKMchr15

72523241

+TUSC3chr8

15397794

+
intron-5UTRENST00000389093ENST00000506802PKMchr15

72523241

+TUSC3chr8

15397794

+
intron-5UTRENST00000389093ENST00000509380PKMchr15

72523241

+TUSC3chr8

15397794

+
intron-5UTRENST00000389093ENST00000503731PKMchr15

72523241

+TUSC3chr8

15397794

+
intron-intronENST00000335181ENST00000503191PKMchr15

72523241

+TUSC3chr8

15397794

+
intron-5UTRENST00000335181ENST00000382020PKMchr15

72523241

+TUSC3chr8

15397794

+
intron-5UTRENST00000335181ENST00000506802PKMchr15

72523241

+TUSC3chr8

15397794

+
intron-5UTRENST00000335181ENST00000509380PKMchr15

72523241

+TUSC3chr8

15397794

+
intron-5UTRENST00000335181ENST00000503731PKMchr15

72523241

+TUSC3chr8

15397794

+
intron-intronENST00000568883ENST00000503191PKMchr15

72523241

+TUSC3chr8

15397794

+
intron-5UTRENST00000568883ENST00000382020PKMchr15

72523241

+TUSC3chr8

15397794

+
intron-5UTRENST00000568883ENST00000506802PKMchr15

72523241

+TUSC3chr8

15397794

+
intron-5UTRENST00000568883ENST00000509380PKMchr15

72523241

+TUSC3chr8

15397794

+
intron-5UTRENST00000568883ENST00000503731PKMchr15

72523241

+TUSC3chr8

15397794

+
intron-intronENST00000449901ENST00000503191PKMchr15

72523241

+TUSC3chr8

15397794

+
intron-5UTRENST00000449901ENST00000382020PKMchr15

72523241

+TUSC3chr8

15397794

+
intron-5UTRENST00000449901ENST00000506802PKMchr15

72523241

+TUSC3chr8

15397794

+
intron-5UTRENST00000449901ENST00000509380PKMchr15

72523241

+TUSC3chr8

15397794

+
intron-5UTRENST00000449901ENST00000503731PKMchr15

72523241

+TUSC3chr8

15397794

+
5UTR-intronENST00000565154ENST00000503191PKMchr15

72523241

+TUSC3chr8

15397794

+
5UTR-5UTRENST00000565154ENST00000382020PKMchr15

72523241

+TUSC3chr8

15397794

+
5UTR-5UTRENST00000565154ENST00000506802PKMchr15

72523241

+TUSC3chr8

15397794

+
5UTR-5UTRENST00000565154ENST00000509380PKMchr15

72523241

+TUSC3chr8

15397794

+
5UTR-5UTRENST00000565154ENST00000503731PKMchr15

72523241

+TUSC3chr8

15397794

+
intron-intronENST00000568459ENST00000503191PKMchr15

72523241

+TUSC3chr8

15397794

+
intron-5UTRENST00000568459ENST00000382020PKMchr15

72523241

+TUSC3chr8

15397794

+
intron-5UTRENST00000568459ENST00000506802PKMchr15

72523241

+TUSC3chr8

15397794

+
intron-5UTRENST00000568459ENST00000509380PKMchr15

72523241

+TUSC3chr8

15397794

+
intron-5UTRENST00000568459ENST00000503731PKMchr15

72523241

+TUSC3chr8

15397794

+

Top

FusionProtFeatures for PKM_TUSC3


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
PKM

P14618

TUSC3

Q13454

Acts as accessory component of the N-oligosaccharyltransferase (OST) complex which catalyzes the transfer of a highmannose oligosaccharide from a lipid-linked oligosaccharide donorto an asparagine residue within an Asn-X-Ser/Thr consensus motifin nascent polypeptide chains. Involved in N-glycosylation ofSTT3B-dependent substrates. Specifically required for theglycosylation of a subset of acceptor sites that are near cysteineresidues; in this function seems to act redundantly with MAGT1. Inits oxidized form proposed to form transient mixed disulfides witha glycoprotein substrate to facilitate access of STT3B to theunmodified acceptor site. Has also oxidoreductase-independentfunctions in the STT3B-containing OST complex possibly involvingsubstrate recognition. {ECO:0000269|PubMed:25135935,ECO:0000305|PubMed:12887896, ECO:0000305|PubMed:24685145}. Magnesium transporter. {ECO:0000269|PubMed:19717468}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


Top

FusionGeneSequence for PKM_TUSC3


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

Top

FusionGenePPI for PKM_TUSC3


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


Top

RelatedDrugs for PKM_TUSC3


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status
HgenePKMP14618DB11638ArtenimolPyruvate kinase PKMsmall moleculeapproved|investigational

Top

RelatedDiseases for PKM_TUSC3


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
HgenePKMC0027626Neoplasm Invasiveness2CTD_human
HgenePKMC0024667Animal Mammary Neoplasms1CTD_human
HgenePKMC0024668Mammary Neoplasms, Experimental1CTD_human
HgenePKMC0029456Osteoporosis1CTD_human
HgenePKMC2239176Liver carcinoma1CTD_human
TgeneTUSC3C0023893Liver Cirrhosis, Experimental1CTD_human