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Fusion gene ID: 27377 |
FusionGeneSummary for PKM_BCR |
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Fusion gene information | Fusion gene name: PKM_BCR | Fusion gene ID: 27377 | Hgene | Tgene | Gene symbol | PKM | BCR | Gene ID | 5315 | 613 |
Gene name | pyruvate kinase M1/2 | BCR, RhoGEF and GTPase activating protein | |
Synonyms | CTHBP|HEL-S-30|OIP3|PK3|PKM2|TCB|THBP1 | ALL|BCR1|CML|D22S11|D22S662|PHL | |
Cytomap | 15q23 | 22q11.23 | |
Type of gene | protein-coding | protein-coding | |
Description | pyruvate kinase PKMOIP-3OPA-interacting protein 3PK, muscle typecytosolic thyroid hormone-binding proteinepididymis secretory protein Li 30p58pyruvate kinase 2/3pyruvate kinase isozymes M1/M2pyruvate kinase muscle isozymepyruvate kinase, muscle | breakpoint cluster region proteinBCR/FGFR1 chimera proteinFGFR1/BCR chimera proteinbreakpoint cluster regionrenal carcinoma antigen NY-REN-26 | |
Modification date | 20180527 | 20180527 | |
UniProtAcc | P14618 | P11274 | |
Ensembl transtripts involved in fusion gene | ENST00000319622, ENST00000565184, ENST00000389093, ENST00000335181, ENST00000568883, ENST00000449901, ENST00000565154, ENST00000568459, | ENST00000305877, ENST00000359540, ENST00000398512, ENST00000436990, | |
Fusion gene scores | * DoF score | 17 X 21 X 3=1071 | 6 X 12 X 4=288 |
# samples | 21 | 15 | |
** MAII score | log2(21/1071*10)=-2.35049724708413 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | log2(15/288*10)=-0.941106310946431 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | |
Context | PubMed: PKM [Title/Abstract] AND BCR [Title/Abstract] AND fusion [Title/Abstract] | ||
Functional or gene categories assigned by FusionGDB annotation |
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
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Partner | Gene | GO ID | GO term | PubMed ID |
Hgene | PKM | GO:0012501 | programmed cell death | 17308100 |
![]() (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
ChiTaRS3.1 | CV350694 | PKM | chr15 | 72502083 | + | BCR | chr22 | 23612698 | + |
* LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
![]() * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
intron-intron | ENST00000319622 | ENST00000305877 | PKM | chr15 | 72502083 | + | BCR | chr22 | 23612698 | + |
intron-intron | ENST00000319622 | ENST00000359540 | PKM | chr15 | 72502083 | + | BCR | chr22 | 23612698 | + |
intron-intron | ENST00000319622 | ENST00000398512 | PKM | chr15 | 72502083 | + | BCR | chr22 | 23612698 | + |
intron-intron | ENST00000319622 | ENST00000436990 | PKM | chr15 | 72502083 | + | BCR | chr22 | 23612698 | + |
intron-intron | ENST00000565184 | ENST00000305877 | PKM | chr15 | 72502083 | + | BCR | chr22 | 23612698 | + |
intron-intron | ENST00000565184 | ENST00000359540 | PKM | chr15 | 72502083 | + | BCR | chr22 | 23612698 | + |
intron-intron | ENST00000565184 | ENST00000398512 | PKM | chr15 | 72502083 | + | BCR | chr22 | 23612698 | + |
intron-intron | ENST00000565184 | ENST00000436990 | PKM | chr15 | 72502083 | + | BCR | chr22 | 23612698 | + |
intron-intron | ENST00000389093 | ENST00000305877 | PKM | chr15 | 72502083 | + | BCR | chr22 | 23612698 | + |
intron-intron | ENST00000389093 | ENST00000359540 | PKM | chr15 | 72502083 | + | BCR | chr22 | 23612698 | + |
intron-intron | ENST00000389093 | ENST00000398512 | PKM | chr15 | 72502083 | + | BCR | chr22 | 23612698 | + |
intron-intron | ENST00000389093 | ENST00000436990 | PKM | chr15 | 72502083 | + | BCR | chr22 | 23612698 | + |
intron-intron | ENST00000335181 | ENST00000305877 | PKM | chr15 | 72502083 | + | BCR | chr22 | 23612698 | + |
intron-intron | ENST00000335181 | ENST00000359540 | PKM | chr15 | 72502083 | + | BCR | chr22 | 23612698 | + |
intron-intron | ENST00000335181 | ENST00000398512 | PKM | chr15 | 72502083 | + | BCR | chr22 | 23612698 | + |
intron-intron | ENST00000335181 | ENST00000436990 | PKM | chr15 | 72502083 | + | BCR | chr22 | 23612698 | + |
intron-intron | ENST00000568883 | ENST00000305877 | PKM | chr15 | 72502083 | + | BCR | chr22 | 23612698 | + |
intron-intron | ENST00000568883 | ENST00000359540 | PKM | chr15 | 72502083 | + | BCR | chr22 | 23612698 | + |
intron-intron | ENST00000568883 | ENST00000398512 | PKM | chr15 | 72502083 | + | BCR | chr22 | 23612698 | + |
intron-intron | ENST00000568883 | ENST00000436990 | PKM | chr15 | 72502083 | + | BCR | chr22 | 23612698 | + |
intron-intron | ENST00000449901 | ENST00000305877 | PKM | chr15 | 72502083 | + | BCR | chr22 | 23612698 | + |
intron-intron | ENST00000449901 | ENST00000359540 | PKM | chr15 | 72502083 | + | BCR | chr22 | 23612698 | + |
intron-intron | ENST00000449901 | ENST00000398512 | PKM | chr15 | 72502083 | + | BCR | chr22 | 23612698 | + |
intron-intron | ENST00000449901 | ENST00000436990 | PKM | chr15 | 72502083 | + | BCR | chr22 | 23612698 | + |
intron-intron | ENST00000565154 | ENST00000305877 | PKM | chr15 | 72502083 | + | BCR | chr22 | 23612698 | + |
intron-intron | ENST00000565154 | ENST00000359540 | PKM | chr15 | 72502083 | + | BCR | chr22 | 23612698 | + |
intron-intron | ENST00000565154 | ENST00000398512 | PKM | chr15 | 72502083 | + | BCR | chr22 | 23612698 | + |
intron-intron | ENST00000565154 | ENST00000436990 | PKM | chr15 | 72502083 | + | BCR | chr22 | 23612698 | + |
intron-intron | ENST00000568459 | ENST00000305877 | PKM | chr15 | 72502083 | + | BCR | chr22 | 23612698 | + |
intron-intron | ENST00000568459 | ENST00000359540 | PKM | chr15 | 72502083 | + | BCR | chr22 | 23612698 | + |
intron-intron | ENST00000568459 | ENST00000398512 | PKM | chr15 | 72502083 | + | BCR | chr22 | 23612698 | + |
intron-intron | ENST00000568459 | ENST00000436990 | PKM | chr15 | 72502083 | + | BCR | chr22 | 23612698 | + |
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FusionProtFeatures for PKM_BCR |
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Hgene | Tgene |
PKM | BCR |
GTPase-activating protein for RAC1 and CDC42. Promotesthe exchange of RAC or CDC42-bound GDP by GTP, thereby activatingthem. Displays serine/threonine kinase activity.{ECO:0000269|PubMed:1657398, ECO:0000269|PubMed:1903516}. |
![]() * Minus value of BPloci means that the break pointn is located before the CDS. |
- In-frame and retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
- In-frame and not-retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
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FusionGeneSequence for PKM_BCR |
![]() (nt: nucleotides, aa: amino acids) |
* Fusion amino acid sequences. |
* Fusion transcript sequences (only coding sequence (CDS) region). |
* Fusion transcript sequences (Full-length transcript). |
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FusionGenePPI for PKM_BCR |
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Hgene | Hgene's interactors | Tgene | Tgene's interactors |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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RelatedDrugs for PKM_BCR |
![]() (DrugBank Version 5.1.0 2018-04-02) |
Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
Hgene | PKM | P14618 | DB11638 | Artenimol | Pyruvate kinase PKM | small molecule | approved|investigational |
Tgene | BCR | P11274 | DB06616 | Bosutinib | Breakpoint cluster region protein | small molecule | approved |
Tgene | BCR | P11274 | DB01254 | Dasatinib | Breakpoint cluster region protein | small molecule | approved|investigational |
Tgene | BCR | P11274 | DB08901 | Ponatinib | Breakpoint cluster region protein | small molecule | approved|investigational |
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RelatedDiseases for PKM_BCR |
![]() (DisGeNet 4.0) |
Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
Hgene | PKM | C0027626 | Neoplasm Invasiveness | 2 | CTD_human |
Hgene | PKM | C0024667 | Animal Mammary Neoplasms | 1 | CTD_human |
Hgene | PKM | C0024668 | Mammary Neoplasms, Experimental | 1 | CTD_human |
Hgene | PKM | C0029456 | Osteoporosis | 1 | CTD_human |
Hgene | PKM | C2239176 | Liver carcinoma | 1 | CTD_human |
Tgene | BCR | C0005586 | Bipolar Disorder | 4 | PSYGENET |
Tgene | BCR | C0023473 | Myeloid Leukemia, Chronic | 3 | CTD_human;HPO;ORPHANET |
Tgene | BCR | C0005699 | Blast Phase | 1 | CTD_human |
Tgene | BCR | C0023893 | Liver Cirrhosis, Experimental | 1 | CTD_human |
Tgene | BCR | C0027022 | Myeloproliferative disease | 1 | CTD_human;HPO |
Tgene | BCR | C0027540 | Necrosis | 1 | CTD_human |
Tgene | BCR | C0027659 | Neoplasms, Experimental | 1 | CTD_human |
Tgene | BCR | C0041696 | Unipolar Depression | 1 | PSYGENET |
Tgene | BCR | C1269683 | Major Depressive Disorder | 1 | PSYGENET |