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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 27377

FusionGeneSummary for PKM_BCR

check button Fusion gene summary
Fusion gene informationFusion gene name: PKM_BCR
Fusion gene ID: 27377
HgeneTgene
Gene symbol

PKM

BCR

Gene ID

5315

613

Gene namepyruvate kinase M1/2BCR, RhoGEF and GTPase activating protein
SynonymsCTHBP|HEL-S-30|OIP3|PK3|PKM2|TCB|THBP1ALL|BCR1|CML|D22S11|D22S662|PHL
Cytomap

15q23

22q11.23

Type of geneprotein-codingprotein-coding
Descriptionpyruvate kinase PKMOIP-3OPA-interacting protein 3PK, muscle typecytosolic thyroid hormone-binding proteinepididymis secretory protein Li 30p58pyruvate kinase 2/3pyruvate kinase isozymes M1/M2pyruvate kinase muscle isozymepyruvate kinase, musclebreakpoint cluster region proteinBCR/FGFR1 chimera proteinFGFR1/BCR chimera proteinbreakpoint cluster regionrenal carcinoma antigen NY-REN-26
Modification date2018052720180527
UniProtAcc

P14618

P11274

Ensembl transtripts involved in fusion geneENST00000319622, ENST00000565184, 
ENST00000389093, ENST00000335181, 
ENST00000568883, ENST00000449901, 
ENST00000565154, ENST00000568459, 
ENST00000305877, ENST00000359540, 
ENST00000398512, ENST00000436990, 
Fusion gene scores* DoF score17 X 21 X 3=10716 X 12 X 4=288
# samples 2115
** MAII scorelog2(21/1071*10)=-2.35049724708413
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
log2(15/288*10)=-0.941106310946431
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: PKM [Title/Abstract] AND BCR [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgenePKM

GO:0012501

programmed cell death

17308100


check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChiTaRS3.1CV350694PKMchr15

72502083

+BCRchr22

23612698

+
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
intron-intronENST00000319622ENST00000305877PKMchr15

72502083

+BCRchr22

23612698

+
intron-intronENST00000319622ENST00000359540PKMchr15

72502083

+BCRchr22

23612698

+
intron-intronENST00000319622ENST00000398512PKMchr15

72502083

+BCRchr22

23612698

+
intron-intronENST00000319622ENST00000436990PKMchr15

72502083

+BCRchr22

23612698

+
intron-intronENST00000565184ENST00000305877PKMchr15

72502083

+BCRchr22

23612698

+
intron-intronENST00000565184ENST00000359540PKMchr15

72502083

+BCRchr22

23612698

+
intron-intronENST00000565184ENST00000398512PKMchr15

72502083

+BCRchr22

23612698

+
intron-intronENST00000565184ENST00000436990PKMchr15

72502083

+BCRchr22

23612698

+
intron-intronENST00000389093ENST00000305877PKMchr15

72502083

+BCRchr22

23612698

+
intron-intronENST00000389093ENST00000359540PKMchr15

72502083

+BCRchr22

23612698

+
intron-intronENST00000389093ENST00000398512PKMchr15

72502083

+BCRchr22

23612698

+
intron-intronENST00000389093ENST00000436990PKMchr15

72502083

+BCRchr22

23612698

+
intron-intronENST00000335181ENST00000305877PKMchr15

72502083

+BCRchr22

23612698

+
intron-intronENST00000335181ENST00000359540PKMchr15

72502083

+BCRchr22

23612698

+
intron-intronENST00000335181ENST00000398512PKMchr15

72502083

+BCRchr22

23612698

+
intron-intronENST00000335181ENST00000436990PKMchr15

72502083

+BCRchr22

23612698

+
intron-intronENST00000568883ENST00000305877PKMchr15

72502083

+BCRchr22

23612698

+
intron-intronENST00000568883ENST00000359540PKMchr15

72502083

+BCRchr22

23612698

+
intron-intronENST00000568883ENST00000398512PKMchr15

72502083

+BCRchr22

23612698

+
intron-intronENST00000568883ENST00000436990PKMchr15

72502083

+BCRchr22

23612698

+
intron-intronENST00000449901ENST00000305877PKMchr15

72502083

+BCRchr22

23612698

+
intron-intronENST00000449901ENST00000359540PKMchr15

72502083

+BCRchr22

23612698

+
intron-intronENST00000449901ENST00000398512PKMchr15

72502083

+BCRchr22

23612698

+
intron-intronENST00000449901ENST00000436990PKMchr15

72502083

+BCRchr22

23612698

+
intron-intronENST00000565154ENST00000305877PKMchr15

72502083

+BCRchr22

23612698

+
intron-intronENST00000565154ENST00000359540PKMchr15

72502083

+BCRchr22

23612698

+
intron-intronENST00000565154ENST00000398512PKMchr15

72502083

+BCRchr22

23612698

+
intron-intronENST00000565154ENST00000436990PKMchr15

72502083

+BCRchr22

23612698

+
intron-intronENST00000568459ENST00000305877PKMchr15

72502083

+BCRchr22

23612698

+
intron-intronENST00000568459ENST00000359540PKMchr15

72502083

+BCRchr22

23612698

+
intron-intronENST00000568459ENST00000398512PKMchr15

72502083

+BCRchr22

23612698

+
intron-intronENST00000568459ENST00000436990PKMchr15

72502083

+BCRchr22

23612698

+

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FusionProtFeatures for PKM_BCR


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
PKM

P14618

BCR

P11274

GTPase-activating protein for RAC1 and CDC42. Promotesthe exchange of RAC or CDC42-bound GDP by GTP, thereby activatingthem. Displays serine/threonine kinase activity.{ECO:0000269|PubMed:1657398, ECO:0000269|PubMed:1903516}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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FusionGeneSequence for PKM_BCR


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for PKM_BCR


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for PKM_BCR


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status
HgenePKMP14618DB11638ArtenimolPyruvate kinase PKMsmall moleculeapproved|investigational
TgeneBCRP11274DB06616BosutinibBreakpoint cluster region proteinsmall moleculeapproved
TgeneBCRP11274DB01254DasatinibBreakpoint cluster region proteinsmall moleculeapproved|investigational
TgeneBCRP11274DB08901PonatinibBreakpoint cluster region proteinsmall moleculeapproved|investigational

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RelatedDiseases for PKM_BCR


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
HgenePKMC0027626Neoplasm Invasiveness2CTD_human
HgenePKMC0024667Animal Mammary Neoplasms1CTD_human
HgenePKMC0024668Mammary Neoplasms, Experimental1CTD_human
HgenePKMC0029456Osteoporosis1CTD_human
HgenePKMC2239176Liver carcinoma1CTD_human
TgeneBCRC0005586Bipolar Disorder4PSYGENET
TgeneBCRC0023473Myeloid Leukemia, Chronic3CTD_human;HPO;ORPHANET
TgeneBCRC0005699Blast Phase1CTD_human
TgeneBCRC0023893Liver Cirrhosis, Experimental1CTD_human
TgeneBCRC0027022Myeloproliferative disease1CTD_human;HPO
TgeneBCRC0027540Necrosis1CTD_human
TgeneBCRC0027659Neoplasms, Experimental1CTD_human
TgeneBCRC0041696Unipolar Depression1PSYGENET
TgeneBCRC1269683Major Depressive Disorder1PSYGENET