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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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Fusion gene ID: 27355

FusionGeneSummary for PKD1_RPS15A

check button Fusion gene summary
Fusion gene informationFusion gene name: PKD1_RPS15A
Fusion gene ID: 27355
HgeneTgene
Gene symbol

PKD1

RPS15A

Gene ID

5310

6210

Gene namepolycystin 1, transient receptor potential channel interactingribosomal protein S15a
SynonymsPBP|PC1|Pc-1|TRPP1S15a
Cytomap

16p13.3

16p12.3

Type of geneprotein-codingprotein-coding
Descriptionpolycystin-1autosomal dominant polycystic kidney disease 1 proteinpolycystic kidney disease 1 (autosomal dominant)polycystic kidney disease-associated proteintransient receptor potential cation channel, subfamily P, member 140S ribosomal protein S15asmall ribosomal subunit protein uS8up-regulated by HBV X protein
Modification date2018052220180523
UniProtAcc

P98161

P62244

Ensembl transtripts involved in fusion geneENST00000423118, ENST00000262304, 
ENST00000561991, 		ENST00000322989, 
ENST00000563390, ENST00000575669, 
ENST00000576436, ENST00000565420, 
ENST00000569083, 
Fusion gene scores* DoF score3 X 2 X 3=184 X 4 X 4=64
# samples 34
** MAII scorelog2(3/18*10)=0.736965594166206
effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs).
DoF>8 and MAII>0		log2(4/64*10)=-0.678071905112638
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: PKD1 [Title/Abstract] AND RPS15A [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotationTumor suppressor gene involved fusion gene, in-frame but not retained their domain.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgenePKD1

GO:0031659

positive regulation of cyclin-dependent protein serine/threonine kinase activity involved in G1/S transition of mitotic cell cycle

16311606

HgenePKD1

GO:0045944

positive regulation of transcription by RNA polymerase II

16311606

HgenePKD1

GO:0048754

branching morphogenesis of an epithelial tube

12482949

HgenePKD1

GO:0061136

regulation of proteasomal protein catabolic process

23001567

TgeneRPS15A

GO:0008284

positive regulation of cell proliferation

15108328

TgeneRPS15A

GO:0009615

response to virus

15108328

TgeneRPS15A

GO:0045787

positive regulation of cell cycle

15108328


check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
TCGALDLIHCTCGA-BC-A10T-01APKD1chr16

2185476

-RPS15Achr16

18796145

-
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
In-frameENST00000423118ENST00000322989PKD1chr16

2185476

-RPS15Achr16

18796145

-
In-frameENST00000423118ENST00000563390PKD1chr16

2185476

-RPS15Achr16

18796145

-
5CDS-5UTRENST00000423118ENST00000575669PKD1chr16

2185476

-RPS15Achr16

18796145

-
5CDS-5UTRENST00000423118ENST00000576436PKD1chr16

2185476

-RPS15Achr16

18796145

-
5CDS-5UTRENST00000423118ENST00000565420PKD1chr16

2185476

-RPS15Achr16

18796145

-
5CDS-5UTRENST00000423118ENST00000569083PKD1chr16

2185476

-RPS15Achr16

18796145

-
In-frameENST00000262304ENST00000322989PKD1chr16

2185476

-RPS15Achr16

18796145

-
In-frameENST00000262304ENST00000563390PKD1chr16

2185476

-RPS15Achr16

18796145

-
5CDS-5UTRENST00000262304ENST00000575669PKD1chr16

2185476

-RPS15Achr16

18796145

-
5CDS-5UTRENST00000262304ENST00000576436PKD1chr16

2185476

-RPS15Achr16

18796145

-
5CDS-5UTRENST00000262304ENST00000565420PKD1chr16

2185476

-RPS15Achr16

18796145

-
5CDS-5UTRENST00000262304ENST00000569083PKD1chr16

2185476

-RPS15Achr16

18796145

-
intron-3CDSENST00000561991ENST00000322989PKD1chr16

2185476

-RPS15Achr16

18796145

-
intron-3CDSENST00000561991ENST00000563390PKD1chr16

2185476

-RPS15Achr16

18796145

-
intron-5UTRENST00000561991ENST00000575669PKD1chr16

2185476

-RPS15Achr16

18796145

-
intron-5UTRENST00000561991ENST00000576436PKD1chr16

2185476

-RPS15Achr16

18796145

-
intron-5UTRENST00000561991ENST00000565420PKD1chr16

2185476

-RPS15Achr16

18796145

-
intron-5UTRENST00000561991ENST00000569083PKD1chr16

2185476

-RPS15Achr16

18796145

-

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FusionProtFeatures for PKD1_RPS15A


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
PKD1

P98161

RPS15A

P62244

Involved in renal tubulogenesis (PubMed:12482949).Involved in fluid-flow mechanosensation by the primary cilium inrenal epithelium (By similarity). Acts as a regulator of ciliumlength, together with PKD2 (By similarity). The dynamic control ofcilium length is essential in the regulation ofmechanotransductive signaling (By similarity). The cilium lengthresponse creates a negative feedback loop whereby fluid shear-mediated deflection of the primary cilium, which decreasesintracellular cAMP, leads to cilium shortening and thus decreasesflow-induced signaling (By similarity). May be an ion-channelregulator. Involved in adhesive protein-protein and protein-carbohydrate interactions. {ECO:0000250|UniProtKB:O08852,ECO:0000269|PubMed:12482949}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgenePKD1chr16:2185476chr16:18796145ENST00000262304-14624_67714304DomainNote=LRRNT
HgenePKD1chr16:2185476chr16:18796145ENST00000423118-14624_67714303DomainNote=LRRNT

- In-frame and not-retained protein feature among the 13 regional features.
>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgenePKD1chr16:2185476chr16:18796145ENST00000262304-1464220_4251714304Coiled coilOntology_term=ECO:0000255
HgenePKD1chr16:2185476chr16:18796145ENST00000423118-1464220_4251714303Coiled coilOntology_term=ECO:0000255
HgenePKD1chr16:2185476chr16:18796145ENST00000262304-1461023_1129714304DomainPKD 5
HgenePKD1chr16:2185476chr16:18796145ENST00000262304-1461127_1215714304DomainPKD 6
HgenePKD1chr16:2185476chr16:18796145ENST00000262304-1461213_1298714304DomainPKD 7
HgenePKD1chr16:2185476chr16:18796145ENST00000262304-146125_178714304DomainNote=LRRCT
HgenePKD1chr16:2185476chr16:18796145ENST00000262304-1461294_1383714304DomainPKD 8
HgenePKD1chr16:2185476chr16:18796145ENST00000262304-1461382_1469714304DomainPKD 9
HgenePKD1chr16:2185476chr16:18796145ENST00000262304-1461468_1551714304DomainPKD 10
HgenePKD1chr16:2185476chr16:18796145ENST00000262304-1461550_1635714304DomainPKD 11
HgenePKD1chr16:2185476chr16:18796145ENST00000262304-1461634_1721714304DomainPKD 12
HgenePKD1chr16:2185476chr16:18796145ENST00000262304-1461719_1805714304DomainPKD 13
HgenePKD1chr16:2185476chr16:18796145ENST00000262304-146177_271714304DomainWSC
HgenePKD1chr16:2185476chr16:18796145ENST00000262304-1461807_1890714304DomainPKD 14
HgenePKD1chr16:2185476chr16:18796145ENST00000262304-1461889_1974714304DomainPKD 15
HgenePKD1chr16:2185476chr16:18796145ENST00000262304-1461977_2057714304DomainPKD 16
HgenePKD1chr16:2185476chr16:18796145ENST00000262304-1462060_2148714304DomainPKD 17
HgenePKD1chr16:2185476chr16:18796145ENST00000262304-1462146_2833714304DomainREJ
HgenePKD1chr16:2185476chr16:18796145ENST00000262304-146272_359714304DomainPKD 1
HgenePKD1chr16:2185476chr16:18796145ENST00000262304-1463012_3061714304DomainGPS
HgenePKD1chr16:2185476chr16:18796145ENST00000262304-1463118_3233714304DomainPLAT
HgenePKD1chr16:2185476chr16:18796145ENST00000262304-146415_531714304DomainC-type lectin
HgenePKD1chr16:2185476chr16:18796145ENST00000262304-146638_671714304DomainNote=LDL-receptor class A%3B atypical
HgenePKD1chr16:2185476chr16:18796145ENST00000262304-146743_817714304DomainPKD 2
HgenePKD1chr16:2185476chr16:18796145ENST00000262304-146855_928714304DomainPKD 3
HgenePKD1chr16:2185476chr16:18796145ENST00000262304-146935_1020714304DomainPKD 4
HgenePKD1chr16:2185476chr16:18796145ENST00000423118-1461023_1129714303DomainPKD 5
HgenePKD1chr16:2185476chr16:18796145ENST00000423118-1461127_1215714303DomainPKD 6
HgenePKD1chr16:2185476chr16:18796145ENST00000423118-1461213_1298714303DomainPKD 7
HgenePKD1chr16:2185476chr16:18796145ENST00000423118-146125_178714303DomainNote=LRRCT
HgenePKD1chr16:2185476chr16:18796145ENST00000423118-1461294_1383714303DomainPKD 8
HgenePKD1chr16:2185476chr16:18796145ENST00000423118-1461382_1469714303DomainPKD 9
HgenePKD1chr16:2185476chr16:18796145ENST00000423118-1461468_1551714303DomainPKD 10
HgenePKD1chr16:2185476chr16:18796145ENST00000423118-1461550_1635714303DomainPKD 11
HgenePKD1chr16:2185476chr16:18796145ENST00000423118-1461634_1721714303DomainPKD 12
HgenePKD1chr16:2185476chr16:18796145ENST00000423118-1461719_1805714303DomainPKD 13
HgenePKD1chr16:2185476chr16:18796145ENST00000423118-146177_271714303DomainWSC
HgenePKD1chr16:2185476chr16:18796145ENST00000423118-1461807_1890714303DomainPKD 14
HgenePKD1chr16:2185476chr16:18796145ENST00000423118-1461889_1974714303DomainPKD 15
HgenePKD1chr16:2185476chr16:18796145ENST00000423118-1461977_2057714303DomainPKD 16
HgenePKD1chr16:2185476chr16:18796145ENST00000423118-1462060_2148714303DomainPKD 17
HgenePKD1chr16:2185476chr16:18796145ENST00000423118-1462146_2833714303DomainREJ
HgenePKD1chr16:2185476chr16:18796145ENST00000423118-146272_359714303DomainPKD 1
HgenePKD1chr16:2185476chr16:18796145ENST00000423118-1463012_3061714303DomainGPS
HgenePKD1chr16:2185476chr16:18796145ENST00000423118-1463118_3233714303DomainPLAT
HgenePKD1chr16:2185476chr16:18796145ENST00000423118-146415_531714303DomainC-type lectin
HgenePKD1chr16:2185476chr16:18796145ENST00000423118-146638_671714303DomainNote=LDL-receptor class A%3B atypical
HgenePKD1chr16:2185476chr16:18796145ENST00000423118-146743_817714303DomainPKD 2
HgenePKD1chr16:2185476chr16:18796145ENST00000423118-146855_928714303DomainPKD 3
HgenePKD1chr16:2185476chr16:18796145ENST00000423118-146935_1020714303DomainPKD 4
HgenePKD1chr16:2185476chr16:18796145ENST00000262304-14668_91714304RepeatNote=LRR 1
HgenePKD1chr16:2185476chr16:18796145ENST00000262304-14692_113714304RepeatNote=LRR 2
HgenePKD1chr16:2185476chr16:18796145ENST00000423118-14668_91714303RepeatNote=LRR 1
HgenePKD1chr16:2185476chr16:18796145ENST00000423118-14692_113714303RepeatNote=LRR 2
HgenePKD1chr16:2185476chr16:18796145ENST00000262304-14624_3074714304Topological domainExtracellular
HgenePKD1chr16:2185476chr16:18796145ENST00000262304-1463096_3282714304Topological domainCytoplasmic
HgenePKD1chr16:2185476chr16:18796145ENST00000262304-1463304_3323714304Topological domainExtracellular
HgenePKD1chr16:2185476chr16:18796145ENST00000262304-1463345_3559714304Topological domainCytoplasmic
HgenePKD1chr16:2185476chr16:18796145ENST00000262304-1463581_3582714304Topological domainExtracellular
HgenePKD1chr16:2185476chr16:18796145ENST00000262304-1463604_3673714304Topological domainCytoplasmic
HgenePKD1chr16:2185476chr16:18796145ENST00000262304-1463695_3896714304Topological domainExtracellular
HgenePKD1chr16:2185476chr16:18796145ENST00000262304-1463918_3938714304Topological domainCytoplasmic
HgenePKD1chr16:2185476chr16:18796145ENST00000262304-1463960_3979714304Topological domainExtracellular
HgenePKD1chr16:2185476chr16:18796145ENST00000262304-1464001_4027714304Topological domainCytoplasmic
HgenePKD1chr16:2185476chr16:18796145ENST00000262304-1464049_4085714304Topological domainExtracellular
HgenePKD1chr16:2185476chr16:18796145ENST00000262304-1464107_4303714304Topological domainCytoplasmic
HgenePKD1chr16:2185476chr16:18796145ENST00000423118-14624_3074714303Topological domainExtracellular
HgenePKD1chr16:2185476chr16:18796145ENST00000423118-1463096_3282714303Topological domainCytoplasmic
HgenePKD1chr16:2185476chr16:18796145ENST00000423118-1463304_3323714303Topological domainExtracellular
HgenePKD1chr16:2185476chr16:18796145ENST00000423118-1463345_3559714303Topological domainCytoplasmic
HgenePKD1chr16:2185476chr16:18796145ENST00000423118-1463581_3582714303Topological domainExtracellular
HgenePKD1chr16:2185476chr16:18796145ENST00000423118-1463604_3673714303Topological domainCytoplasmic
HgenePKD1chr16:2185476chr16:18796145ENST00000423118-1463695_3896714303Topological domainExtracellular
HgenePKD1chr16:2185476chr16:18796145ENST00000423118-1463918_3938714303Topological domainCytoplasmic
HgenePKD1chr16:2185476chr16:18796145ENST00000423118-1463960_3979714303Topological domainExtracellular
HgenePKD1chr16:2185476chr16:18796145ENST00000423118-1464001_4027714303Topological domainCytoplasmic
HgenePKD1chr16:2185476chr16:18796145ENST00000423118-1464049_4085714303Topological domainExtracellular
HgenePKD1chr16:2185476chr16:18796145ENST00000423118-1464107_4303714303Topological domainCytoplasmic
HgenePKD1chr16:2185476chr16:18796145ENST00000262304-1463075_3095714304TransmembraneHelical
HgenePKD1chr16:2185476chr16:18796145ENST00000262304-1463283_3303714304TransmembraneHelical
HgenePKD1chr16:2185476chr16:18796145ENST00000262304-1463324_3344714304TransmembraneHelical
HgenePKD1chr16:2185476chr16:18796145ENST00000262304-1463560_3580714304TransmembraneHelical
HgenePKD1chr16:2185476chr16:18796145ENST00000262304-1463583_3603714304TransmembraneHelical
HgenePKD1chr16:2185476chr16:18796145ENST00000262304-1463674_3694714304TransmembraneHelical
HgenePKD1chr16:2185476chr16:18796145ENST00000262304-1463897_3917714304TransmembraneHelical
HgenePKD1chr16:2185476chr16:18796145ENST00000262304-1463939_3959714304TransmembraneHelical
HgenePKD1chr16:2185476chr16:18796145ENST00000262304-1463980_4000714304TransmembraneHelical
HgenePKD1chr16:2185476chr16:18796145ENST00000262304-1464028_4048714304TransmembraneHelical
HgenePKD1chr16:2185476chr16:18796145ENST00000262304-1464086_4106714304TransmembraneHelical
HgenePKD1chr16:2185476chr16:18796145ENST00000423118-1463075_3095714303TransmembraneHelical
HgenePKD1chr16:2185476chr16:18796145ENST00000423118-1463283_3303714303TransmembraneHelical
HgenePKD1chr16:2185476chr16:18796145ENST00000423118-1463324_3344714303TransmembraneHelical
HgenePKD1chr16:2185476chr16:18796145ENST00000423118-1463560_3580714303TransmembraneHelical
HgenePKD1chr16:2185476chr16:18796145ENST00000423118-1463583_3603714303TransmembraneHelical
HgenePKD1chr16:2185476chr16:18796145ENST00000423118-1463674_3694714303TransmembraneHelical
HgenePKD1chr16:2185476chr16:18796145ENST00000423118-1463897_3917714303TransmembraneHelical
HgenePKD1chr16:2185476chr16:18796145ENST00000423118-1463939_3959714303TransmembraneHelical
HgenePKD1chr16:2185476chr16:18796145ENST00000423118-1463980_4000714303TransmembraneHelical
HgenePKD1chr16:2185476chr16:18796145ENST00000423118-1464028_4048714303TransmembraneHelical
HgenePKD1chr16:2185476chr16:18796145ENST00000423118-1464086_4106714303TransmembraneHelical


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FusionGeneSequence for PKD1_RPS15A


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.
>In-frame_PKD1_ENST00000423118_chr16_2185476_-_RPS15A_ENST00000322989_chr16_18796145_-_131aa
MPPAAPARLALALGLGLWLGALAGGPGRGCGPCEPPCLCGPAPGAACRVNCSGRGLRTLGPALRIPADATALVGXSAPDLTCNSKTWKNG

>In-frame_PKD1_ENST00000423118_chr16_2185476_-_RPS15A_ENST00000563390_chr16_18796145_-_131aa
MPPAAPARLALALGLGLWLGALAGGPGRGCGPCEPPCLCGPAPGAACRVNCSGRGLRTLGPALRIPADATALVGXSAPDLTCNSKTWKNG

>In-frame_PKD1_ENST00000262304_chr16_2185476_-_RPS15A_ENST00000322989_chr16_18796145_-_131aa
MPPAAPARLALALGLGLWLGALAGGPGRGCGPCEPPCLCGPAPGAACRVNCSGRGLRTLGPALRIPADATALVGXSAPDLTCNSKTWKNG

>In-frame_PKD1_ENST00000262304_chr16_2185476_-_RPS15A_ENST00000563390_chr16_18796145_-_131aa
MPPAAPARLALALGLGLWLGALAGGPGRGCGPCEPPCLCGPAPGAACRVNCSGRGLRTLGPALRIPADATALVGXSAPDLTCNSKTWKNG


* Fusion transcript sequences (only coding sequence (CDS) region).
>In-frame_PKD1_ENST00000423118_chr16_2185476_-_RPS15A_ENST00000322989_chr16_18796145_-_395nt
ATGCCGCCCGCCGCGCCCGCCCGCCTGGCGCTGGCCCTGGGCCTGGGCCTGTGGCTCGGGGCGCTGGCGGGGGGCCCCGGGCGCGGCTGC
GGGCCCTGCGAGCCCCCCTGCCTCTGCGGCCCAGCGCCCGGCGCCGCCTGCCGCGTCAACTGCTCGGGCCGCGGGCTGCGGACGCTCGGT
CCCGCGCTGCGCATCCCCGCGGACGCCACAGCGCTTGTGGGGTGATCAGCCCCAGATTTGACGTGCAACTCAAAGACCTGGAAAAATGGC
AGAATAATCTGCTTCCATCCCGCCAGTTTGGTTTCATTGTACTGACAACCTCAGCTGGCATCATGGACCATGAAGAAGCAAGACGAAAAC

>In-frame_PKD1_ENST00000423118_chr16_2185476_-_RPS15A_ENST00000563390_chr16_18796145_-_395nt
ATGCCGCCCGCCGCGCCCGCCCGCCTGGCGCTGGCCCTGGGCCTGGGCCTGTGGCTCGGGGCGCTGGCGGGGGGCCCCGGGCGCGGCTGC
GGGCCCTGCGAGCCCCCCTGCCTCTGCGGCCCAGCGCCCGGCGCCGCCTGCCGCGTCAACTGCTCGGGCCGCGGGCTGCGGACGCTCGGT
CCCGCGCTGCGCATCCCCGCGGACGCCACAGCGCTTGTGGGGTGATCAGCCCCAGATTTGACGTGCAACTCAAAGACCTGGAAAAATGGC
AGAATAATCTGCTTCCATCCCGCCAGTTTGGTTTCATTGTACTGACAACCTCAGCTGGCATCATGGACCATGAAGAAGCAAGACGAAAAC

>In-frame_PKD1_ENST00000262304_chr16_2185476_-_RPS15A_ENST00000322989_chr16_18796145_-_395nt
ATGCCGCCCGCCGCGCCCGCCCGCCTGGCGCTGGCCCTGGGCCTGGGCCTGTGGCTCGGGGCGCTGGCGGGGGGCCCCGGGCGCGGCTGC
GGGCCCTGCGAGCCCCCCTGCCTCTGCGGCCCAGCGCCCGGCGCCGCCTGCCGCGTCAACTGCTCGGGCCGCGGGCTGCGGACGCTCGGT
CCCGCGCTGCGCATCCCCGCGGACGCCACAGCGCTTGTGGGGTGATCAGCCCCAGATTTGACGTGCAACTCAAAGACCTGGAAAAATGGC
AGAATAATCTGCTTCCATCCCGCCAGTTTGGTTTCATTGTACTGACAACCTCAGCTGGCATCATGGACCATGAAGAAGCAAGACGAAAAC

>In-frame_PKD1_ENST00000262304_chr16_2185476_-_RPS15A_ENST00000563390_chr16_18796145_-_395nt
ATGCCGCCCGCCGCGCCCGCCCGCCTGGCGCTGGCCCTGGGCCTGGGCCTGTGGCTCGGGGCGCTGGCGGGGGGCCCCGGGCGCGGCTGC
GGGCCCTGCGAGCCCCCCTGCCTCTGCGGCCCAGCGCCCGGCGCCGCCTGCCGCGTCAACTGCTCGGGCCGCGGGCTGCGGACGCTCGGT
CCCGCGCTGCGCATCCCCGCGGACGCCACAGCGCTTGTGGGGTGATCAGCCCCAGATTTGACGTGCAACTCAAAGACCTGGAAAAATGGC
AGAATAATCTGCTTCCATCCCGCCAGTTTGGTTTCATTGTACTGACAACCTCAGCTGGCATCATGGACCATGAAGAAGCAAGACGAAAAC


* Fusion transcript sequences (Full-length transcript).
>In-frame_PKD1_ENST00000423118_chr16_2185476_-_RPS15A_ENST00000322989_chr16_18796145_-_2318nt
GCACTGCAGCGCCAGCGTCCGAGCGGGCGGCCGAGCTCCCGGAGCGGCCTGGCCCCGAGCCCCGAGCGGGCGTCGCTCAGCAGCAGGTCG
CGGCCGCAGCCCCATCCAGCCCCGCGCCCGCCATGCCGTCCGCGGGCCCCGCCTGAGCTGCGGCCTCCGCGCGCGGGCGGGCCTGGGGAC
GGCGGGGCCATGCGCGCGCTGCCCTAACGATGCCGCCCGCCGCGCCCGCCCGCCTGGCGCTGGCCCTGGGCCTGGGCCTGTGGCTCGGGG
CGCTGGCGGGGGGCCCCGGGCGCGGCTGCGGGCCCTGCGAGCCCCCCTGCCTCTGCGGCCCAGCGCCCGGCGCCGCCTGCCGCGTCAACT
GCTCGGGCCGCGGGCTGCGGACGCTCGGTCCCGCGCTGCGCATCCCCGCGGACGCCACAGCGCTTGTGGGGTGATCAGCCCCAGATTTGA
CGTGCAACTCAAAGACCTGGAAAAATGGCAGAATAATCTGCTTCCATCCCGCCAGTTTGGTTTCATTGTACTGACAACCTCAGCTGGCAT
CATGGACCATGAAGAAGCAAGACGAAAACACACAGGAGGGAAAATCCTGGGATTCTTTTTCTAGGGATGTAATACATATATTTACAAATA
AAATGCCTCATGGACTCTGGTGCTTCCACTTGGTCGTTTTGAGCCTTTACAGCAGTGTAGCCACAGCTTCTGCGGCAGCATGCAGTTGCT
TCGTTTATCGGTGAATGCGATTCCCTGAAGTGACTAATACAGCCAAGGGAAAAAGTTCTTATGAAACCAGTATGCCTAAGAAACAGTCAC
CCCTGCTGTCTGCCAAAACCAGGTATTTGACACTAAATATTTTAGTTGTATTTCAGTTTTTTTTTTTTTTTTTCTTTTTTGGAGACAGAG
TCTGACTCTATTGCTCAGGCTGGAGTGCAGTGGCGCGATCTTGGCCCACTGCAACCTCCACCTCCCGGGTTCAAGTGATTGTCCTGTCTC
AGCCGCCTGAGTAACTGGGATTACAAGTGTGTGTCGCCACATCCGGCTAATTTTTATATTTTAGTAGAGACAGGGTTTCGCCATGTTGCC
CAGGCTGGTCTTGAGTTCTGGGCCTCAAGTGATCAGCCTACCTCGGCCTCCCGAAGTGCTGGGATTACAGCCACGAGCCATTACACCTGG
CCTATATTTCAGTATTTTCTATTAGTTTTTGATGAATTTGTTTTGCCTGGCTAGGATTATTCTGTAGATAGGATTTTAGATCTGGCTTTT
GTCACTGACTGCTGTAATAAATACTTGCTAGGAATTTTTTTTTTTTTTTTTTTTTTTTTAAGACAAAGTCGCTCTGTCACACAGGCTGGA
GTGCAGTGGCATGATCTTGGCTCACTGCACCTCCGCTTCCCAGATTCAAGTAGTTCTCGTGCCTCAGCCTCCTGAGTAGCTGGGATTACA
GGTGTGTGCCACCATGTCTGGCTGATTTTTGTATTTTTAGTAGAGGTGGGGTTTCACCATGTTGGCCAGGCTGGTCTCGAACTCCTGATC
TCAAGTGATCTGCCTGCCTTGGTCTCCCAAAGTGCTGGGATTACAGGTGTGACCACCACGCCCTGCCTTAAGAATTGTTCCAAGAGAATC
TGGTGCCACTTGCAGGTGCCCATTGAAGTGCAATGGGCACTGTTGATCACTGAGGAGGTAGTGGGTGCTGACCCGGTGCTGGGGCCTGTC
CCCTAGTCTCTGCTTTGCCCTTGGCTAGCTAGGTGGTGTGCCAAGTGGGGAGAGAAGCTACCTTATTAAGGGGCATGGATCAGCTTCCTG
AAAGGAGGGCCTGCCTCTGTAAGATATGGGAAGTCGCTGAGAATGTTACAGAACGGCCCTAGAGATGGGGCAGATAACGGCCCCCATTTG
TGAGAAGTGAGTTGGGAGGCATGTTTGGGGCCTCTGATGTTTGGGAGGCTGTGGGTAATTAACATGAGTTTTGGGGTCCAGCAGCAGAAT
TCAGGTTTCCTCTTCCACTCAGTAACCTCAGCATCCGTATCTGTAATGGGAATGATACAAAACCTATCCCCAAGTTGAGGGAAAAATGAG
ATTGTGTAAAGCGCACTTGGCACATGACAGTCACAAGCATGGGGACAGTGAGTCCAGAAGGATTTTCTTATGCCAGCATTGTAAGCCCTA
GGATCACAGGGCTCTGGCTTGTTTAACCATCGTGTCTCTGGTCCCTAGCCTGCAAACCTGGTGTGTAGGGATGCCTCAGTCGCTTACATG

>In-frame_PKD1_ENST00000423118_chr16_2185476_-_RPS15A_ENST00000563390_chr16_18796145_-_657nt
GCACTGCAGCGCCAGCGTCCGAGCGGGCGGCCGAGCTCCCGGAGCGGCCTGGCCCCGAGCCCCGAGCGGGCGTCGCTCAGCAGCAGGTCG
CGGCCGCAGCCCCATCCAGCCCCGCGCCCGCCATGCCGTCCGCGGGCCCCGCCTGAGCTGCGGCCTCCGCGCGCGGGCGGGCCTGGGGAC
GGCGGGGCCATGCGCGCGCTGCCCTAACGATGCCGCCCGCCGCGCCCGCCCGCCTGGCGCTGGCCCTGGGCCTGGGCCTGTGGCTCGGGG
CGCTGGCGGGGGGCCCCGGGCGCGGCTGCGGGCCCTGCGAGCCCCCCTGCCTCTGCGGCCCAGCGCCCGGCGCCGCCTGCCGCGTCAACT
GCTCGGGCCGCGGGCTGCGGACGCTCGGTCCCGCGCTGCGCATCCCCGCGGACGCCACAGCGCTTGTGGGGTGATCAGCCCCAGATTTGA
CGTGCAACTCAAAGACCTGGAAAAATGGCAGAATAATCTGCTTCCATCCCGCCAGTTTGGTTTCATTGTACTGACAACCTCAGCTGGCAT
CATGGACCATGAAGAAGCAAGACGAAAACACACAGGAGGGAAAATCCTGGGATTCTTTTTCTAGGGATGTAATACATATATTTACAAATA

>In-frame_PKD1_ENST00000262304_chr16_2185476_-_RPS15A_ENST00000322989_chr16_18796145_-_2318nt
GCACTGCAGCGCCAGCGTCCGAGCGGGCGGCCGAGCTCCCGGAGCGGCCTGGCCCCGAGCCCCGAGCGGGCGTCGCTCAGCAGCAGGTCG
CGGCCGCAGCCCCATCCAGCCCCGCGCCCGCCATGCCGTCCGCGGGCCCCGCCTGAGCTGCGGCCTCCGCGCGCGGGCGGGCCTGGGGAC
GGCGGGGCCATGCGCGCGCTGCCCTAACGATGCCGCCCGCCGCGCCCGCCCGCCTGGCGCTGGCCCTGGGCCTGGGCCTGTGGCTCGGGG
CGCTGGCGGGGGGCCCCGGGCGCGGCTGCGGGCCCTGCGAGCCCCCCTGCCTCTGCGGCCCAGCGCCCGGCGCCGCCTGCCGCGTCAACT
GCTCGGGCCGCGGGCTGCGGACGCTCGGTCCCGCGCTGCGCATCCCCGCGGACGCCACAGCGCTTGTGGGGTGATCAGCCCCAGATTTGA
CGTGCAACTCAAAGACCTGGAAAAATGGCAGAATAATCTGCTTCCATCCCGCCAGTTTGGTTTCATTGTACTGACAACCTCAGCTGGCAT
CATGGACCATGAAGAAGCAAGACGAAAACACACAGGAGGGAAAATCCTGGGATTCTTTTTCTAGGGATGTAATACATATATTTACAAATA
AAATGCCTCATGGACTCTGGTGCTTCCACTTGGTCGTTTTGAGCCTTTACAGCAGTGTAGCCACAGCTTCTGCGGCAGCATGCAGTTGCT
TCGTTTATCGGTGAATGCGATTCCCTGAAGTGACTAATACAGCCAAGGGAAAAAGTTCTTATGAAACCAGTATGCCTAAGAAACAGTCAC
CCCTGCTGTCTGCCAAAACCAGGTATTTGACACTAAATATTTTAGTTGTATTTCAGTTTTTTTTTTTTTTTTTCTTTTTTGGAGACAGAG
TCTGACTCTATTGCTCAGGCTGGAGTGCAGTGGCGCGATCTTGGCCCACTGCAACCTCCACCTCCCGGGTTCAAGTGATTGTCCTGTCTC
AGCCGCCTGAGTAACTGGGATTACAAGTGTGTGTCGCCACATCCGGCTAATTTTTATATTTTAGTAGAGACAGGGTTTCGCCATGTTGCC
CAGGCTGGTCTTGAGTTCTGGGCCTCAAGTGATCAGCCTACCTCGGCCTCCCGAAGTGCTGGGATTACAGCCACGAGCCATTACACCTGG
CCTATATTTCAGTATTTTCTATTAGTTTTTGATGAATTTGTTTTGCCTGGCTAGGATTATTCTGTAGATAGGATTTTAGATCTGGCTTTT
GTCACTGACTGCTGTAATAAATACTTGCTAGGAATTTTTTTTTTTTTTTTTTTTTTTTTAAGACAAAGTCGCTCTGTCACACAGGCTGGA
GTGCAGTGGCATGATCTTGGCTCACTGCACCTCCGCTTCCCAGATTCAAGTAGTTCTCGTGCCTCAGCCTCCTGAGTAGCTGGGATTACA
GGTGTGTGCCACCATGTCTGGCTGATTTTTGTATTTTTAGTAGAGGTGGGGTTTCACCATGTTGGCCAGGCTGGTCTCGAACTCCTGATC
TCAAGTGATCTGCCTGCCTTGGTCTCCCAAAGTGCTGGGATTACAGGTGTGACCACCACGCCCTGCCTTAAGAATTGTTCCAAGAGAATC
TGGTGCCACTTGCAGGTGCCCATTGAAGTGCAATGGGCACTGTTGATCACTGAGGAGGTAGTGGGTGCTGACCCGGTGCTGGGGCCTGTC
CCCTAGTCTCTGCTTTGCCCTTGGCTAGCTAGGTGGTGTGCCAAGTGGGGAGAGAAGCTACCTTATTAAGGGGCATGGATCAGCTTCCTG
AAAGGAGGGCCTGCCTCTGTAAGATATGGGAAGTCGCTGAGAATGTTACAGAACGGCCCTAGAGATGGGGCAGATAACGGCCCCCATTTG
TGAGAAGTGAGTTGGGAGGCATGTTTGGGGCCTCTGATGTTTGGGAGGCTGTGGGTAATTAACATGAGTTTTGGGGTCCAGCAGCAGAAT
TCAGGTTTCCTCTTCCACTCAGTAACCTCAGCATCCGTATCTGTAATGGGAATGATACAAAACCTATCCCCAAGTTGAGGGAAAAATGAG
ATTGTGTAAAGCGCACTTGGCACATGACAGTCACAAGCATGGGGACAGTGAGTCCAGAAGGATTTTCTTATGCCAGCATTGTAAGCCCTA
GGATCACAGGGCTCTGGCTTGTTTAACCATCGTGTCTCTGGTCCCTAGCCTGCAAACCTGGTGTGTAGGGATGCCTCAGTCGCTTACATG

>In-frame_PKD1_ENST00000262304_chr16_2185476_-_RPS15A_ENST00000563390_chr16_18796145_-_657nt
GCACTGCAGCGCCAGCGTCCGAGCGGGCGGCCGAGCTCCCGGAGCGGCCTGGCCCCGAGCCCCGAGCGGGCGTCGCTCAGCAGCAGGTCG
CGGCCGCAGCCCCATCCAGCCCCGCGCCCGCCATGCCGTCCGCGGGCCCCGCCTGAGCTGCGGCCTCCGCGCGCGGGCGGGCCTGGGGAC
GGCGGGGCCATGCGCGCGCTGCCCTAACGATGCCGCCCGCCGCGCCCGCCCGCCTGGCGCTGGCCCTGGGCCTGGGCCTGTGGCTCGGGG
CGCTGGCGGGGGGCCCCGGGCGCGGCTGCGGGCCCTGCGAGCCCCCCTGCCTCTGCGGCCCAGCGCCCGGCGCCGCCTGCCGCGTCAACT
GCTCGGGCCGCGGGCTGCGGACGCTCGGTCCCGCGCTGCGCATCCCCGCGGACGCCACAGCGCTTGTGGGGTGATCAGCCCCAGATTTGA
CGTGCAACTCAAAGACCTGGAAAAATGGCAGAATAATCTGCTTCCATCCCGCCAGTTTGGTTTCATTGTACTGACAACCTCAGCTGGCAT
CATGGACCATGAAGAAGCAAGACGAAAACACACAGGAGGGAAAATCCTGGGATTCTTTTTCTAGGGATGTAATACATATATTTACAAATA


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FusionGenePPI for PKD1_RPS15A


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors
PKD1PKD2, RGS7, FN1, COL1A1, KRT18, COL2A1, SIAH1, HDAC9, MARK2, PKD1, ATP1A1, CFTR, JADE1, PTK2, CTNNB1, GANRPS15AEWSR1, ELF5, MGMT, CALM1, CDC37, PCK1, VHL, RAD21, HDGF, CUL3, CUL4A, CUL5, CUL2, CDK2, CUL1, COPS5, COPS6, CAND1, NEDD8, RPL10A, RPL10, RPL11, RPL12, RPL14, RPL15, RPL18A, RPL18, RPL19, RPL21, RPL23, RPL24, RPL27, RPL30, RPL31, RPL37A, RPL4, RPL5, RPL6, RPL7A, RPL7, RPL9, RPS10, RPS11, RPS12, RPS13, RPS14, RPS19, RPS26, RPS3A, RPS3, RPS4X, RPS5, RPS6, RPS7, RPS8, RPSA, RPS23, RPS16, RPS17, RPLP1, RPS24, RPLP2, RPL23A, RPS2, RPLP0, RPS20, RPS15, RPL3, RPL13, RPL38, RPL29, RPS21, RPL17, RPL32, RPS27A, EEF1A1, EEF2, NOP56, FBL, HNRNPU, GNL3, SLC25A5, ILF3, ILF2, NOP58, MOV10, TUFM, NHP2L1, HNRNPM, ACTA2, EIF6, HSP90AA1, RPLP0P6, RPL10L, GALNT2, NOP2, NIFK, MRPS14, UBA2, GNL1, HIST1H2AD, HSPA8, ATP5A1, HNRNPA0, PSMB1, ESR1, SMURF1, FN1, VCAM1, UBL4A, ITGA4, PAN2, PSMC1, PSMC6, PSMD11, PSMD3, FAU, PNO1, PSMD1, RPS18, RPS25, RPS27, RPS27L, RPS29, RPS9, WDR26, WIBG, RPS28, TSR1, ZBTB1, CEP250, CEP57, CEP76, TUBG1, HUWE1, RNF2, EGFR, DIMT1, IMP3, MPHOSPH10, MRPL14, MRPL16, MRPL22, MRPS7, RPL13A, RPL27A, RPL28, RPL34, RPL35, RPL37, DDX18, RPL22, RPL35A, RPL36, RPL8, VAPA, LOC101929876, TUBB, TUBB2B, TUBB4B, UBA52, SFN, PTEN, AHSA1, EXOSC1, UBE3A, MCM2, RHOU, RC3H1, ZNF746, HNRNPA1, CYLD, TRIM25, UBE2A, HEY1, BRCA1, HDAC6


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for PKD1_RPS15A


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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RelatedDiseases for PKD1_RPS15A


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
HgenePKD1C3149841POLYCYSTIC KIDNEY DISEASE 126UNIPROT
HgenePKD1C0085413Polycystic Kidney, Autosomal Dominant5CTD_human
HgenePKD1C0022680Polycystic Kidney Diseases2CTD_human;HPO
HgenePKD1C0010709Cyst1CTD_human