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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 27348

FusionGeneSummary for PIWIL4_THRSP

check button Fusion gene summary
Fusion gene informationFusion gene name: PIWIL4_THRSP
Fusion gene ID: 27348
HgeneTgene
Gene symbol

PIWIL4

THRSP

Gene ID

143689

7069

Gene namepiwi like RNA-mediated gene silencing 4thyroid hormone responsive
SynonymsHIWI2|MIWI2LPGP1|Lpgp|S14|SPOT14|THRP
Cytomap

11q21

11q14.1

Type of geneprotein-codingprotein-coding
Descriptionpiwi-like protein 4piwi-like 4testis tissue sperm-binding protein Li 85Pthyroid hormone-inducible hepatic proteinSPOT14 homologlipogenic protein 1spot 14 proteinthyroid hormone responsive (SPOT14 homolog, rat)thyroid hormone responsive SPOT14
Modification date2018051920180522
UniProtAcc

Q7Z3Z4

Q92748

Ensembl transtripts involved in fusion geneENST00000299001, ENST00000537419, 
ENST00000281030, 
Fusion gene scores* DoF score2 X 3 X 2=129 X 1 X 5=45
# samples 29
** MAII scorelog2(2/12*10)=0.736965594166206
effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs).
DoF>8 and MAII>0
log2(9/45*10)=1
effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs).
DoF>8 and MAII>0
Context

PubMed: PIWIL4 [Title/Abstract] AND THRSP [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID

check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
TCGARVSARCTCGA-DX-A3LT-01APIWIL4chr11

94301974

+THRSPchr11

77778705

+
TCGALDSARCTCGA-DX-A3LT-01APIWIL4chr11

94310658

+THRSPchr11

77778705

+
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
5CDS-3UTRENST00000299001ENST00000281030PIWIL4chr11

94301974

+THRSPchr11

77778705

+
intron-3UTRENST00000537419ENST00000281030PIWIL4chr11

94301974

+THRSPchr11

77778705

+
5CDS-3UTRENST00000299001ENST00000281030PIWIL4chr11

94310658

+THRSPchr11

77778705

+
intron-3UTRENST00000537419ENST00000281030PIWIL4chr11

94310658

+THRSPchr11

77778705

+

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FusionProtFeatures for PIWIL4_THRSP


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
PIWIL4

Q7Z3Z4

THRSP

Q92748

Plays a central role during spermatogenesis byrepressing transposable elements and preventing theirmobilization, which is essential for the germline integrity (Bysimilarity). Acts via the piRNA metabolic process, which mediatesthe repression of transposable elements during meiosis by formingcomplexes composed of piRNAs and Piwi proteins and governs themethylation and subsequent repression of transposons (Bysimilarity). Directly binds piRNAs, a class of 24 to 30 nucleotideRNAs that are generated by a Dicer-independent mechanism and areprimarily derived from transposons and other repeated sequenceelements (By similarity). Associates with secondary piRNAsantisense and PIWIL2/MILI is required for such association (Bysimilarity). The piRNA process acts upstream of known mediators ofDNA methylation (By similarity). Does not show endonucleaseactivity (By similarity). Plays a key role in the piRNAamplification loop, also named ping-pong amplification cycle, byacting as a 'slicer-incompetent' component that loads cleavedpiRNAs from the 'slicer-competent' component PIWIL2 and targetthem on genomic transposon loci in the nucleus (By similarity).May be involved in the chromatin-modifying pathway by inducing'Lys-9' methylation of histone H3 at some loci (PubMed:17544373).{ECO:0000250|UniProtKB:Q8CGT6, ECO:0000269|PubMed:17544373}. Plays a role in the regulation of lipogenesis,especially in lactating mammary gland. Important for thebiosynthesis of triglycerides with medium-length fatty acidchains. May modulate lipogenesis by interacting with MID1IP1 andpreventing its interaction with ACACA (By similarity). Mayfunction as transcriptional coactivator. May modulate thetranscription factor activity of THRB. {ECO:0000250,ECO:0000269|PubMed:17418816, ECO:0000269|PubMed:18299245}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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FusionGeneSequence for PIWIL4_THRSP


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for PIWIL4_THRSP


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors
PIWIL4DICER1, RELATHRSPTHRSP, AKT1, AURKA, BAG4, BCAR3, BRMS1, FZR1, ERBB2, FGFR4, HMMR, IGF1R, KRAS, LSP1, PALB2, PARP1, PIK3CA, PTPN1, RB1CC1, SMAD4, STK11, TGFB1, TSG101, WT1


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for PIWIL4_THRSP


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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RelatedDiseases for PIWIL4_THRSP


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
HgenePIWIL4C0028960Oligospermia1CTD_human
TgeneTHRSPC0024667Animal Mammary Neoplasms1CTD_human
TgeneTHRSPC0024668Mammary Neoplasms, Experimental1CTD_human