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Fusion gene ID: 27344 |
FusionGeneSummary for PITX2_PPP1R15A |
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Fusion gene information | Fusion gene name: PITX2_PPP1R15A | Fusion gene ID: 27344 | Hgene | Tgene | Gene symbol | PITX2 | PPP1R15A | Gene ID | 5308 | 23645 |
Gene name | paired like homeodomain 2 | protein phosphatase 1 regulatory subunit 15A | |
Synonyms | ARP1|ASGD4|Brx1|IDG2|IGDS|IGDS2|IHG2|IRID2|Otlx2|PTX2|RGS|RIEG|RIEG1|RS | GADD34 | |
Cytomap | 4q25 | 19q13.33 | |
Type of gene | protein-coding | protein-coding | |
Description | pituitary homeobox 2ALL1-responsive protein ARP1all1-responsive gene 1homeobox protein PITX2paired-like homeodomain transcription factor 2rieg bicoid-related homeobox transcription factor 1solurshin | protein phosphatase 1 regulatory subunit 15Agrowth arrest and DNA damage-inducible protein GADD34growth arrest and DNA-damage-inducible 34myeloid differentiation primary response protein MyD116 homologprotein phosphatase 1, regulatory (inhibitor) subu | |
Modification date | 20180523 | 20180523 | |
UniProtAcc | Q99697 | O75807 | |
Ensembl transtripts involved in fusion gene | ENST00000306732, ENST00000394598, ENST00000355080, ENST00000354925, ENST00000394595, ENST00000557119, ENST00000556049, | ENST00000200453, | |
Fusion gene scores | * DoF score | 1 X 1 X 1=1 | 3 X 3 X 1=9 |
# samples | 1 | 3 | |
** MAII score | log2(1/1*10)=3.32192809488736 | log2(3/9*10)=1.73696559416621 effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs). DoF>8 and MAII>0 | |
Context | PubMed: PITX2 [Title/Abstract] AND PPP1R15A [Title/Abstract] AND fusion [Title/Abstract] | ||
Functional or gene categories assigned by FusionGDB annotation |
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
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Partner | Gene | GO ID | GO term | PubMed ID |
Hgene | PITX2 | GO:0006355 | regulation of transcription, DNA-templated | 15385555 |
Hgene | PITX2 | GO:0006357 | regulation of transcription by RNA polymerase II | 23975681 |
Hgene | PITX2 | GO:0045944 | positive regulation of transcription by RNA polymerase II | 9685346|19251162 |
Tgene | PPP1R15A | GO:0032515 | negative regulation of phosphoprotein phosphatase activity | 11564868 |
Tgene | PPP1R15A | GO:0032516 | positive regulation of phosphoprotein phosphatase activity | 11564868 |
Tgene | PPP1R15A | GO:0034976 | response to endoplasmic reticulum stress | 12556489 |
Tgene | PPP1R15A | GO:0035308 | negative regulation of protein dephosphorylation | 11564868 |
Tgene | PPP1R15A | GO:0036496 | regulation of translational initiation by eIF2 alpha dephosphorylation | 12556489 |
Tgene | PPP1R15A | GO:1902310 | positive regulation of peptidyl-serine dephosphorylation | 11564868|12556489|21518769 |
Tgene | PPP1R15A | GO:1903917 | positive regulation of endoplasmic reticulum stress-induced eIF2 alpha dephosphorylation | 21518769 |
![]() (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
ChiTaRS3.1 | BC007987 | PITX2 | chr4 | 111541433 | - | PPP1R15A | chr19 | 49377702 | + |
* LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
![]() * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
intron-3CDS | ENST00000306732 | ENST00000200453 | PITX2 | chr4 | 111541433 | - | PPP1R15A | chr19 | 49377702 | + |
intron-3CDS | ENST00000394598 | ENST00000200453 | PITX2 | chr4 | 111541433 | - | PPP1R15A | chr19 | 49377702 | + |
intron-3CDS | ENST00000355080 | ENST00000200453 | PITX2 | chr4 | 111541433 | - | PPP1R15A | chr19 | 49377702 | + |
intron-3CDS | ENST00000354925 | ENST00000200453 | PITX2 | chr4 | 111541433 | - | PPP1R15A | chr19 | 49377702 | + |
intron-3CDS | ENST00000394595 | ENST00000200453 | PITX2 | chr4 | 111541433 | - | PPP1R15A | chr19 | 49377702 | + |
Frame-shift | ENST00000557119 | ENST00000200453 | PITX2 | chr4 | 111541433 | - | PPP1R15A | chr19 | 49377702 | + |
intron-3CDS | ENST00000556049 | ENST00000200453 | PITX2 | chr4 | 111541433 | - | PPP1R15A | chr19 | 49377702 | + |
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FusionProtFeatures for PITX2_PPP1R15A |
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Hgene | Tgene |
PITX2 | PPP1R15A |
Recruits the serine/threonine-protein phosphatase PP1 todephosphorylate the translation initiation factor eIF-2A/EIF2S1,thereby reversing the shut-off of protein synthesis initiated bystress-inducible kinases and facilitating recovery of cells fromstress. Down-regulates the TGF-beta signaling pathway by promotingdephosphorylation of TGFB1 by PP1. May promote apoptosis byinducing TP53 phosphorylation on 'Ser-15'.{ECO:0000269|PubMed:11564868, ECO:0000269|PubMed:12556489,ECO:0000269|PubMed:14635196, ECO:0000269|PubMed:14718519,ECO:0000269|PubMed:8139541}. |
![]() * Minus value of BPloci means that the break pointn is located before the CDS. |
- In-frame and retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
- In-frame and not-retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
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FusionGeneSequence for PITX2_PPP1R15A |
![]() (nt: nucleotides, aa: amino acids) |
* Fusion amino acid sequences. |
* Fusion transcript sequences (only coding sequence (CDS) region). |
* Fusion transcript sequences (Full-length transcript). |
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FusionGenePPI for PITX2_PPP1R15A |
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Hgene | Hgene's interactors | Tgene | Tgene's interactors |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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RelatedDrugs for PITX2_PPP1R15A |
![]() (DrugBank Version 5.1.0 2018-04-02) |
Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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RelatedDiseases for PITX2_PPP1R15A |
![]() (DisGeNet 4.0) |
Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
Hgene | PITX2 | C3714873 | Axenfeld-Rieger Syndrome, Type 1 | 10 | CTD_human;UNIPROT |
Hgene | PITX2 | C0376634 | Craniofacial Abnormalities | 2 | CTD_human |
Hgene | PITX2 | C1842031 | IRIDOGONIODYSGENESIS, TYPE 2 | 2 | CTD_human;UNIPROT |
Hgene | PITX2 | C1867155 | RING DERMOID OF CORNEA | 2 | CTD_human;ORPHANET;UNIPROT |
Hgene | PITX2 | C0018798 | Congenital Heart Defects | 1 | CTD_human |
Hgene | PITX2 | C0040427 | Tooth Abnormalities | 1 | CTD_human;HPO |