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Fusion gene ID: 2730 |
FusionGeneSummary for ARL4D_TSN |
 Fusion gene summary |
| Fusion gene information | Fusion gene name: ARL4D_TSN | Fusion gene ID: 2730 | Hgene | Tgene | Gene symbol | ARL4D | TSN | Gene ID | 379 | 7247 |
| Gene name | ADP ribosylation factor like GTPase 4D | translin | |
| Synonyms | ARF4L|ARL6 | BCLF-1|C3PO|RCHF1|REHF-1|TBRBP|TRSLN | |
| Cytomap | 17q21.31 | 2q14.3 | |
| Type of gene | protein-coding | protein-coding | |
| Description | ADP-ribosylation factor-like protein 4DADP-ribosylation factor-like 4DADP-ribosylation factor-like 6ADP-ribosylation factor-like protein 4L | translincomponent 3 of promoter of RISCrecombination hotspot associated factorrecombination hotspot-binding proteintestis brain-RNA binding protein | |
| Modification date | 20180523 | 20180523 | |
| UniProtAcc | P49703 | Q15631 | |
| Ensembl transtripts involved in fusion gene | ENST00000320033, | ENST00000389682, ENST00000498545, ENST00000536142, ENST00000409193, | |
| Fusion gene scores | * DoF score | 3 X 4 X 2=24 | 5 X 6 X 1=30 |
| # samples | 4 | 6 | |
| ** MAII score | log2(4/24*10)=0.736965594166206 effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs). DoF>8 and MAII>0 | log2(6/30*10)=1 effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs). DoF>8 and MAII>0 | |
| Context | PubMed: ARL4D [Title/Abstract] AND TSN [Title/Abstract] AND fusion [Title/Abstract] | ||
| Functional or gene categories assigned by FusionGDB annotation | |||
| * DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
| Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Partner | Gene | GO ID | GO term | PubMed ID |
| Fusion gene information from three resources (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| ChiTaRS3.1 | AW163818 | ARL4D | chr17 | 41477958 | + | TSN | chr2 | 122519075 | - |
| * LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
| Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| 3UTR-3CDS | ENST00000320033 | ENST00000389682 | ARL4D | chr17 | 41477958 | + | TSN | chr2 | 122519075 | - |
| 3UTR-intron | ENST00000320033 | ENST00000498545 | ARL4D | chr17 | 41477958 | + | TSN | chr2 | 122519075 | - |
| 3UTR-intron | ENST00000320033 | ENST00000536142 | ARL4D | chr17 | 41477958 | + | TSN | chr2 | 122519075 | - |
| 3UTR-intron | ENST00000320033 | ENST00000409193 | ARL4D | chr17 | 41477958 | + | TSN | chr2 | 122519075 | - |
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FusionProtFeatures for ARL4D_TSN |
| Main function of each fusion partner protein. (from UniProt) |
| Hgene | Tgene |
| ARL4D | TSN |
| Small GTP-binding protein which cycles between aninactive GDP-bound and an active GTP-bound form, and the rate ofcycling is regulated by guanine nucleotide exchange factors (GEF)and GTPase-activating proteins (GAP). GTP-binding protein thatdoes not act as an allosteric activator of the cholera toxincatalytic subunit. Recruits CYTH1, CYTH2, CYTH3 and CYTH4 to theplasma membrane in GDP-bound form. {ECO:0000269|PubMed:17398095}. | DNA-binding protein that specifically recognizesconsensus sequences at the breakpoint junctions in chromosomaltranslocations, mostly involving immunoglobulin (Ig)/T-cellreceptor gene segments. Seems to recognize single-stranded DNAends generated by staggered breaks occurring at recombination hotspots. Exhibits both single-stranded and double-strandedendoribonuclease activity. May act as an activator of RNA-inducedsilencing complex (RISC) by facilitating endonucleolytic cleavageof the siRNA passenger strand. |
| Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at . * Minus value of BPloci means that the break pointn is located before the CDS. |
| - In-frame and retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
| - In-frame and not-retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
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FusionGeneSequence for ARL4D_TSN |
| For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. (nt: nucleotides, aa: amino acids) |
| * Fusion amino acid sequences. |
| * Fusion transcript sequences (only coding sequence (CDS) region). |
| * Fusion transcript sequences (Full-length transcript). |
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FusionGenePPI for ARL4D_TSN |
| Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in . |
| Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160) |
| Hgene | Hgene's interactors | Tgene | Tgene's interactors |
| - Retained PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
| - Lost PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
| - Retained PPIs, but lost function due to frame-shift fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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RelatedDrugs for ARL4D_TSN |
| Drugs targeting genes involved in this fusion gene. (DrugBank Version 5.1.0 2018-04-02) |
| Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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RelatedDiseases for ARL4D_TSN |
| Diseases associated with fusion partners. (DisGeNet 4.0) |
| Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
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