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Fusion gene ID: 27295 |
FusionGeneSummary for PITPNA_KCNIP4 |
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Fusion gene information | Fusion gene name: PITPNA_KCNIP4 | Fusion gene ID: 27295 | Hgene | Tgene | Gene symbol | PITPNA | KCNIP4 | Gene ID | 5306 | 80333 |
Gene name | phosphatidylinositol transfer protein alpha | potassium voltage-gated channel interacting protein 4 | |
Synonyms | HEL-S-36|PI-TPalpha|PITPN|VIB1A | CALP|KCHIP4 | |
Cytomap | 17p13.3 | 4p15.31-p15.2 | |
Type of gene | protein-coding | protein-coding | |
Description | phosphatidylinositol transfer protein alpha isoformPI-TP-alphaepididymis secretory protein Li 36ptdIns transfer protein alphaptdInsTP alpha | Kv channel-interacting protein 4Kv channel interacting protein 4a-type potassium channel modulatory protein 4calsenilin-like protein | |
Modification date | 20180523 | 20180523 | |
UniProtAcc | Q00169 | Q6PIL6 | |
Ensembl transtripts involved in fusion gene | ENST00000313486, ENST00000539476, | ENST00000382148, ENST00000447367, ENST00000382150, ENST00000382152, ENST00000509207, ENST00000382149, ENST00000359001, | |
Fusion gene scores | * DoF score | 9 X 8 X 7=504 | 12 X 7 X 9=756 |
# samples | 10 | 13 | |
** MAII score | log2(10/504*10)=-2.33342373372519 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | log2(13/756*10)=-2.53987461119262 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | |
Context | PubMed: PITPNA [Title/Abstract] AND KCNIP4 [Title/Abstract] AND fusion [Title/Abstract] | ||
Functional or gene categories assigned by FusionGDB annotation |
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
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Partner | Gene | GO ID | GO term | PubMed ID |
Hgene | PITPNA | GO:0015914 | phospholipid transport | 16274224|22822086 |
![]() (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
TCGA | LD | UCEC | TCGA-D1-A3DH-01A | PITPNA | chr17 | 1451590 | - | KCNIP4 | chr4 | 20852290 | - |
* LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
![]() * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
Frame-shift | ENST00000313486 | ENST00000382148 | PITPNA | chr17 | 1451590 | - | KCNIP4 | chr4 | 20852290 | - |
Frame-shift | ENST00000313486 | ENST00000447367 | PITPNA | chr17 | 1451590 | - | KCNIP4 | chr4 | 20852290 | - |
Frame-shift | ENST00000313486 | ENST00000382150 | PITPNA | chr17 | 1451590 | - | KCNIP4 | chr4 | 20852290 | - |
Frame-shift | ENST00000313486 | ENST00000382152 | PITPNA | chr17 | 1451590 | - | KCNIP4 | chr4 | 20852290 | - |
5CDS-5UTR | ENST00000313486 | ENST00000509207 | PITPNA | chr17 | 1451590 | - | KCNIP4 | chr4 | 20852290 | - |
5CDS-5UTR | ENST00000313486 | ENST00000382149 | PITPNA | chr17 | 1451590 | - | KCNIP4 | chr4 | 20852290 | - |
5CDS-5UTR | ENST00000313486 | ENST00000359001 | PITPNA | chr17 | 1451590 | - | KCNIP4 | chr4 | 20852290 | - |
Frame-shift | ENST00000539476 | ENST00000382148 | PITPNA | chr17 | 1451590 | - | KCNIP4 | chr4 | 20852290 | - |
Frame-shift | ENST00000539476 | ENST00000447367 | PITPNA | chr17 | 1451590 | - | KCNIP4 | chr4 | 20852290 | - |
Frame-shift | ENST00000539476 | ENST00000382150 | PITPNA | chr17 | 1451590 | - | KCNIP4 | chr4 | 20852290 | - |
Frame-shift | ENST00000539476 | ENST00000382152 | PITPNA | chr17 | 1451590 | - | KCNIP4 | chr4 | 20852290 | - |
5CDS-5UTR | ENST00000539476 | ENST00000509207 | PITPNA | chr17 | 1451590 | - | KCNIP4 | chr4 | 20852290 | - |
5CDS-5UTR | ENST00000539476 | ENST00000382149 | PITPNA | chr17 | 1451590 | - | KCNIP4 | chr4 | 20852290 | - |
5CDS-5UTR | ENST00000539476 | ENST00000359001 | PITPNA | chr17 | 1451590 | - | KCNIP4 | chr4 | 20852290 | - |
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FusionProtFeatures for PITPNA_KCNIP4 |
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Hgene | Tgene |
PITPNA | KCNIP4 |
Catalyzes the transfer of PtdIns and phosphatidylcholinebetween membranes. |
![]() * Minus value of BPloci means that the break pointn is located before the CDS. |
- In-frame and retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
- In-frame and not-retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
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FusionGeneSequence for PITPNA_KCNIP4 |
![]() (nt: nucleotides, aa: amino acids) |
* Fusion amino acid sequences. |
* Fusion transcript sequences (only coding sequence (CDS) region). |
* Fusion transcript sequences (Full-length transcript). |
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FusionGenePPI for PITPNA_KCNIP4 |
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Hgene | Hgene's interactors | Tgene | Tgene's interactors |
PITPNA | PMVK, MORF4L2, MLKL, SCP2, CSNK2B, ACP1, CCDC58, GOT1, HADH, HSPB1, NECAP1, VAPA, UBE2L3, PLK1, S1PR4 | KCNIP4 | KCNIP2, PSEN2, PSEN1, APP, KCNIP1, SCGB1D1, MTX1, LACRT, ZG16B, PRR4, HLA-DRA, KLK4, TFPI, ECE2 |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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RelatedDrugs for PITPNA_KCNIP4 |
![]() (DrugBank Version 5.1.0 2018-04-02) |
Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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RelatedDiseases for PITPNA_KCNIP4 |
![]() (DisGeNet 4.0) |
Partner | Gene | Disease ID | Disease name | # pubmeds | Source |