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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 27291

FusionGeneSummary for PISD_MED15

check button Fusion gene summary
Fusion gene informationFusion gene name: PISD_MED15
Fusion gene ID: 27291
HgeneTgene
Gene symbol

PISD

MED15

Gene ID

23761

51586

Gene namephosphatidylserine decarboxylasemediator complex subunit 15
SynonymsDJ858B16|PSD|PSDC|PSSC|dJ858B16.2ARC105|CAG7A|CTG7A|PCQAP|TIG-1|TIG1|TNRC7
Cytomap

22q12.2

22q11.21

Type of geneprotein-codingprotein-coding
Descriptionphosphatidylserine decarboxylase proenzyme, mitochondrialmediator of RNA polymerase II transcription subunit 15CTG repeat protein 7aPC2 (positive cofactor 2, multiprotein complex) glutamine/Q-rich-associated proteinPC2 glutamine/Q-rich-associated proteinPC2-glutamine-rich-associated proteinTPA inducible ge
Modification date2018052320180523
UniProtAcc

Q9UG56

Q96RN5

Ensembl transtripts involved in fusion geneENST00000382151, ENST00000266095, 
ENST00000397500, ENST00000336566, 
ENST00000439502, ENST00000478893, 
ENST00000425759, ENST00000292733, 
ENST00000542773, ENST00000263205, 
ENST00000406969, ENST00000382974, 
ENST00000541476, ENST00000478831, 
Fusion gene scores* DoF score2 X 3 X 2=1213 X 9 X 7=819
# samples 315
** MAII scorelog2(3/12*10)=1.32192809488736
effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs).
DoF>8 and MAII>0		log2(15/819*10)=-2.44890095114513
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: PISD [Title/Abstract] AND MED15 [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID

check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
TCGALDCOADTCGA-A6-5657-01APISDchr22

32026790

-MED15chr22

20891404

+
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
intron-5UTRENST00000382151ENST00000425759PISDchr22

32026790

-MED15chr22

20891404

+
intron-5UTRENST00000382151ENST00000292733PISDchr22

32026790

-MED15chr22

20891404

+
intron-5UTRENST00000382151ENST00000542773PISDchr22

32026790

-MED15chr22

20891404

+
intron-5UTRENST00000382151ENST00000263205PISDchr22

32026790

-MED15chr22

20891404

+
intron-5UTRENST00000382151ENST00000406969PISDchr22

32026790

-MED15chr22

20891404

+
intron-5UTRENST00000382151ENST00000382974PISDchr22

32026790

-MED15chr22

20891404

+
intron-5UTRENST00000382151ENST00000541476PISDchr22

32026790

-MED15chr22

20891404

+
intron-intronENST00000382151ENST00000478831PISDchr22

32026790

-MED15chr22

20891404

+
5UTR-5UTRENST00000266095ENST00000425759PISDchr22

32026790

-MED15chr22

20891404

+
5UTR-5UTRENST00000266095ENST00000292733PISDchr22

32026790

-MED15chr22

20891404

+
5UTR-5UTRENST00000266095ENST00000542773PISDchr22

32026790

-MED15chr22

20891404

+
5UTR-5UTRENST00000266095ENST00000263205PISDchr22

32026790

-MED15chr22

20891404

+
5UTR-5UTRENST00000266095ENST00000406969PISDchr22

32026790

-MED15chr22

20891404

+
5UTR-5UTRENST00000266095ENST00000382974PISDchr22

32026790

-MED15chr22

20891404

+
5UTR-5UTRENST00000266095ENST00000541476PISDchr22

32026790

-MED15chr22

20891404

+
5UTR-intronENST00000266095ENST00000478831PISDchr22

32026790

-MED15chr22

20891404

+
5UTR-5UTRENST00000397500ENST00000425759PISDchr22

32026790

-MED15chr22

20891404

+
5UTR-5UTRENST00000397500ENST00000292733PISDchr22

32026790

-MED15chr22

20891404

+
5UTR-5UTRENST00000397500ENST00000542773PISDchr22

32026790

-MED15chr22

20891404

+
5UTR-5UTRENST00000397500ENST00000263205PISDchr22

32026790

-MED15chr22

20891404

+
5UTR-5UTRENST00000397500ENST00000406969PISDchr22

32026790

-MED15chr22

20891404

+
5UTR-5UTRENST00000397500ENST00000382974PISDchr22

32026790

-MED15chr22

20891404

+
5UTR-5UTRENST00000397500ENST00000541476PISDchr22

32026790

-MED15chr22

20891404

+
5UTR-intronENST00000397500ENST00000478831PISDchr22

32026790

-MED15chr22

20891404

+
intron-5UTRENST00000336566ENST00000425759PISDchr22

32026790

-MED15chr22

20891404

+
intron-5UTRENST00000336566ENST00000292733PISDchr22

32026790

-MED15chr22

20891404

+
intron-5UTRENST00000336566ENST00000542773PISDchr22

32026790

-MED15chr22

20891404

+
intron-5UTRENST00000336566ENST00000263205PISDchr22

32026790

-MED15chr22

20891404

+
intron-5UTRENST00000336566ENST00000406969PISDchr22

32026790

-MED15chr22

20891404

+
intron-5UTRENST00000336566ENST00000382974PISDchr22

32026790

-MED15chr22

20891404

+
intron-5UTRENST00000336566ENST00000541476PISDchr22

32026790

-MED15chr22

20891404

+
intron-intronENST00000336566ENST00000478831PISDchr22

32026790

-MED15chr22

20891404

+
intron-5UTRENST00000439502ENST00000425759PISDchr22

32026790

-MED15chr22

20891404

+
intron-5UTRENST00000439502ENST00000292733PISDchr22

32026790

-MED15chr22

20891404

+
intron-5UTRENST00000439502ENST00000542773PISDchr22

32026790

-MED15chr22

20891404

+
intron-5UTRENST00000439502ENST00000263205PISDchr22

32026790

-MED15chr22

20891404

+
intron-5UTRENST00000439502ENST00000406969PISDchr22

32026790

-MED15chr22

20891404

+
intron-5UTRENST00000439502ENST00000382974PISDchr22

32026790

-MED15chr22

20891404

+
intron-5UTRENST00000439502ENST00000541476PISDchr22

32026790

-MED15chr22

20891404

+
intron-intronENST00000439502ENST00000478831PISDchr22

32026790

-MED15chr22

20891404

+
intron-5UTRENST00000478893ENST00000425759PISDchr22

32026790

-MED15chr22

20891404

+
intron-5UTRENST00000478893ENST00000292733PISDchr22

32026790

-MED15chr22

20891404

+
intron-5UTRENST00000478893ENST00000542773PISDchr22

32026790

-MED15chr22

20891404

+
intron-5UTRENST00000478893ENST00000263205PISDchr22

32026790

-MED15chr22

20891404

+
intron-5UTRENST00000478893ENST00000406969PISDchr22

32026790

-MED15chr22

20891404

+
intron-5UTRENST00000478893ENST00000382974PISDchr22

32026790

-MED15chr22

20891404

+
intron-5UTRENST00000478893ENST00000541476PISDchr22

32026790

-MED15chr22

20891404

+
intron-intronENST00000478893ENST00000478831PISDchr22

32026790

-MED15chr22

20891404

+

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FusionProtFeatures for PISD_MED15


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
PISD

Q9UG56

MED15

Q96RN5

Catalyzes the formation of phosphatidylethanolamine(PtdEtn) from phosphatidylserine (PtdSer). Plays a central role inphospholipid metabolism and in the interorganelle trafficking ofphosphatidylserine. {ECO:0000255|HAMAP-Rule:MF_03208}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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FusionGeneSequence for PISD_MED15


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for PISD_MED15


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors
PISDDHX29, DAGLB, BRCA1, KIF15, PTPN1, IFT140, WDR19MED15MLLT6, PLSCR1, FHL3, MED10, MED9, MED29, MED19, MED28, MED26, MED25, MED6, ATP5C1, MED1, TRIM11, SMAD1, SMAD2, SMAD3, TRRAP, RELA, SREBF1, MED12, MED18, ZC3H13, TRIP4, QKI, TADA2A, CDK8, MED13, MED14, MED23, MED16, MED17, MED7, CTDP1, ATXN1, IGBP1, UBAP2L, SEC24C, CHEK1, NCOA6, FBXW7, EPAS1, CDK19, CCNC, NR1I3, ALDH8A1, TCL1B, HIF1A, MED11, MED20, MED24, MED27, MED4, MED8, EWSR1, MYO1C, POLR2F, POLR2G, CTDSPL2, MED21, UBE2N, TP73


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for PISD_MED15


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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RelatedDiseases for PISD_MED15


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
TgeneMED15C0036341Schizophrenia2PSYGENET
TgeneMED15C0036337Schizoaffective Disorder1PSYGENET