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Fusion gene ID: 27271 |
FusionGeneSummary for PIP4K2C_MIEN1 |
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Fusion gene information | Fusion gene name: PIP4K2C_MIEN1 | Fusion gene ID: 27271 | Hgene | Tgene | Gene symbol | PIP4K2C | MIEN1 | Gene ID | 79837 | 84299 |
Gene name | phosphatidylinositol-5-phosphate 4-kinase type 2 gamma | migration and invasion enhancer 1 | |
Synonyms | PIP5K2C | C17orf37|C35|ORB3|RDX12|XTP4 | |
Cytomap | 12q13.3 | 17q12 | |
Type of gene | protein-coding | protein-coding | |
Description | phosphatidylinositol 5-phosphate 4-kinase type-2 gammaPI(5)P 4-kinase type II gammaPIP4KII-gammaphosphatidylinositol 4-phosphate 5-kinasephosphatidylinositol 5-phosphate 4-kinase type II gammaphosphatidylinositol-4-phosphate 5-kinase, type II, gamma | migration and invasion enhancer 1HBV X-transactivated gene 4 proteinHBV XAg-transactivated protein 4protein C17orf37 | |
Modification date | 20180519 | 20180523 | |
UniProtAcc | Q8TBX8 | Q9BRT3 | |
Ensembl transtripts involved in fusion gene | ENST00000422156, ENST00000540759, ENST00000550465, ENST00000354947, | ENST00000474210, ENST00000394231, ENST00000577810, | |
Fusion gene scores | * DoF score | 2 X 2 X 2=8 | 13 X 8 X 9=936 |
# samples | 2 | 14 | |
** MAII score | log2(2/8*10)=1.32192809488736 | log2(14/936*10)=-2.74108170263844 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | |
Context | PubMed: PIP4K2C [Title/Abstract] AND MIEN1 [Title/Abstract] AND fusion [Title/Abstract] | ||
Functional or gene categories assigned by FusionGDB annotation |
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
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Partner | Gene | GO ID | GO term | PubMed ID |
Tgene | MIEN1 | GO:0030335 | positive regulation of cell migration | 21628459 |
Tgene | MIEN1 | GO:0043066 | negative regulation of apoptotic process | 21068479 |
Tgene | MIEN1 | GO:0051491 | positive regulation of filopodium assembly | 21628459 |
![]() (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
ChiTaRS3.1 | AW606546 | PIP4K2C | chr12 | 57994730 | + | MIEN1 | chr17 | 37885744 | - |
* LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
![]() * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
5CDS-5UTR | ENST00000422156 | ENST00000474210 | PIP4K2C | chr12 | 57994730 | + | MIEN1 | chr17 | 37885744 | - |
5CDS-3UTR | ENST00000422156 | ENST00000394231 | PIP4K2C | chr12 | 57994730 | + | MIEN1 | chr17 | 37885744 | - |
5CDS-3UTR | ENST00000422156 | ENST00000577810 | PIP4K2C | chr12 | 57994730 | + | MIEN1 | chr17 | 37885744 | - |
5CDS-5UTR | ENST00000540759 | ENST00000474210 | PIP4K2C | chr12 | 57994730 | + | MIEN1 | chr17 | 37885744 | - |
5CDS-3UTR | ENST00000540759 | ENST00000394231 | PIP4K2C | chr12 | 57994730 | + | MIEN1 | chr17 | 37885744 | - |
5CDS-3UTR | ENST00000540759 | ENST00000577810 | PIP4K2C | chr12 | 57994730 | + | MIEN1 | chr17 | 37885744 | - |
5CDS-5UTR | ENST00000550465 | ENST00000474210 | PIP4K2C | chr12 | 57994730 | + | MIEN1 | chr17 | 37885744 | - |
5CDS-3UTR | ENST00000550465 | ENST00000394231 | PIP4K2C | chr12 | 57994730 | + | MIEN1 | chr17 | 37885744 | - |
5CDS-3UTR | ENST00000550465 | ENST00000577810 | PIP4K2C | chr12 | 57994730 | + | MIEN1 | chr17 | 37885744 | - |
5CDS-5UTR | ENST00000354947 | ENST00000474210 | PIP4K2C | chr12 | 57994730 | + | MIEN1 | chr17 | 37885744 | - |
5CDS-3UTR | ENST00000354947 | ENST00000394231 | PIP4K2C | chr12 | 57994730 | + | MIEN1 | chr17 | 37885744 | - |
5CDS-3UTR | ENST00000354947 | ENST00000577810 | PIP4K2C | chr12 | 57994730 | + | MIEN1 | chr17 | 37885744 | - |
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FusionProtFeatures for PIP4K2C_MIEN1 |
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Hgene | Tgene |
PIP4K2C | MIEN1 |
May play an important role in the production ofPhosphatidylinositol bisphosphate (PIP2), in the endoplasmicreticulum. {ECO:0000250}. | Increases cell migration by inducing filopodia formationat the leading edge of migrating cells. Plays a role in regulationof apoptosis, possibly through control of CASP3. May be involvedin a redox-related process. {ECO:0000269|PubMed:19503095,ECO:0000269|PubMed:21628459}. |
![]() * Minus value of BPloci means that the break pointn is located before the CDS. |
- In-frame and retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
- In-frame and not-retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
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FusionGeneSequence for PIP4K2C_MIEN1 |
![]() (nt: nucleotides, aa: amino acids) |
* Fusion amino acid sequences. |
* Fusion transcript sequences (only coding sequence (CDS) region). |
* Fusion transcript sequences (Full-length transcript). |
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FusionGenePPI for PIP4K2C_MIEN1 |
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Hgene | Hgene's interactors | Tgene | Tgene's interactors |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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RelatedDrugs for PIP4K2C_MIEN1 |
![]() (DrugBank Version 5.1.0 2018-04-02) |
Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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RelatedDiseases for PIP4K2C_MIEN1 |
![]() (DisGeNet 4.0) |
Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
Hgene | PIP4K2C | C0036341 | Schizophrenia | 2 | PSYGENET |
Hgene | PIP4K2C | C0005586 | Bipolar Disorder | 1 | PSYGENET |