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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 27271

FusionGeneSummary for PIP4K2C_MIEN1

check button Fusion gene summary
Fusion gene informationFusion gene name: PIP4K2C_MIEN1
Fusion gene ID: 27271
HgeneTgene
Gene symbol

PIP4K2C

MIEN1

Gene ID

79837

84299

Gene namephosphatidylinositol-5-phosphate 4-kinase type 2 gammamigration and invasion enhancer 1
SynonymsPIP5K2CC17orf37|C35|ORB3|RDX12|XTP4
Cytomap

12q13.3

17q12

Type of geneprotein-codingprotein-coding
Descriptionphosphatidylinositol 5-phosphate 4-kinase type-2 gammaPI(5)P 4-kinase type II gammaPIP4KII-gammaphosphatidylinositol 4-phosphate 5-kinasephosphatidylinositol 5-phosphate 4-kinase type II gammaphosphatidylinositol-4-phosphate 5-kinase, type II, gammamigration and invasion enhancer 1HBV X-transactivated gene 4 proteinHBV XAg-transactivated protein 4protein C17orf37
Modification date2018051920180523
UniProtAcc

Q8TBX8

Q9BRT3

Ensembl transtripts involved in fusion geneENST00000422156, ENST00000540759, 
ENST00000550465, ENST00000354947, 
ENST00000474210, ENST00000394231, 
ENST00000577810, 
Fusion gene scores* DoF score2 X 2 X 2=813 X 8 X 9=936
# samples 214
** MAII scorelog2(2/8*10)=1.32192809488736log2(14/936*10)=-2.74108170263844
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: PIP4K2C [Title/Abstract] AND MIEN1 [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
TgeneMIEN1

GO:0030335

positive regulation of cell migration

21628459

TgeneMIEN1

GO:0043066

negative regulation of apoptotic process

21068479

TgeneMIEN1

GO:0051491

positive regulation of filopodium assembly

21628459


check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChiTaRS3.1AW606546PIP4K2Cchr12

57994730

+MIEN1chr17

37885744

-
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
5CDS-5UTRENST00000422156ENST00000474210PIP4K2Cchr12

57994730

+MIEN1chr17

37885744

-
5CDS-3UTRENST00000422156ENST00000394231PIP4K2Cchr12

57994730

+MIEN1chr17

37885744

-
5CDS-3UTRENST00000422156ENST00000577810PIP4K2Cchr12

57994730

+MIEN1chr17

37885744

-
5CDS-5UTRENST00000540759ENST00000474210PIP4K2Cchr12

57994730

+MIEN1chr17

37885744

-
5CDS-3UTRENST00000540759ENST00000394231PIP4K2Cchr12

57994730

+MIEN1chr17

37885744

-
5CDS-3UTRENST00000540759ENST00000577810PIP4K2Cchr12

57994730

+MIEN1chr17

37885744

-
5CDS-5UTRENST00000550465ENST00000474210PIP4K2Cchr12

57994730

+MIEN1chr17

37885744

-
5CDS-3UTRENST00000550465ENST00000394231PIP4K2Cchr12

57994730

+MIEN1chr17

37885744

-
5CDS-3UTRENST00000550465ENST00000577810PIP4K2Cchr12

57994730

+MIEN1chr17

37885744

-
5CDS-5UTRENST00000354947ENST00000474210PIP4K2Cchr12

57994730

+MIEN1chr17

37885744

-
5CDS-3UTRENST00000354947ENST00000394231PIP4K2Cchr12

57994730

+MIEN1chr17

37885744

-
5CDS-3UTRENST00000354947ENST00000577810PIP4K2Cchr12

57994730

+MIEN1chr17

37885744

-

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FusionProtFeatures for PIP4K2C_MIEN1


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
PIP4K2C

Q8TBX8

MIEN1

Q9BRT3

May play an important role in the production ofPhosphatidylinositol bisphosphate (PIP2), in the endoplasmicreticulum. {ECO:0000250}. Increases cell migration by inducing filopodia formationat the leading edge of migrating cells. Plays a role in regulationof apoptosis, possibly through control of CASP3. May be involvedin a redox-related process. {ECO:0000269|PubMed:19503095,ECO:0000269|PubMed:21628459}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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FusionGeneSequence for PIP4K2C_MIEN1


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for PIP4K2C_MIEN1


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for PIP4K2C_MIEN1


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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RelatedDiseases for PIP4K2C_MIEN1


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
HgenePIP4K2CC0036341Schizophrenia2PSYGENET
HgenePIP4K2CC0005586Bipolar Disorder1PSYGENET