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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 27261

FusionGeneSummary for PIP4K2B_KPNB1

check button Fusion gene summary
Fusion gene informationFusion gene name: PIP4K2B_KPNB1
Fusion gene ID: 27261
HgeneTgene
Gene symbol

PIP4K2B

KPNB1

Gene ID

8396

3837

Gene namephosphatidylinositol-5-phosphate 4-kinase type 2 betakaryopherin subunit beta 1
SynonymsPI5P4KB|PIP5K2B|PIP5KIIB|PIP5KIIbeta|PIP5P4KBIMB1|IPO1|IPOB|Impnb|NTF97
Cytomap

17q12

17q21.32

Type of geneprotein-codingprotein-coding
Descriptionphosphatidylinositol 5-phosphate 4-kinase type-2 beta1-phosphatidylinositol 5-phosphate 4-kinase 2-beta1-phosphatidylinositol-4-phosphate kinasePI(5)P 4-kinase type II betaPIP4KII-betaPTDINS(4)P-5-kinasediphosphoinositide kinase 2-betaphosphatidyliimportin subunit beta-1PTAC97importin 1importin 90importin beta-1 subunitkaryopherin (importin) beta 1nuclear factor p97pore targeting complex 97 kDa subunit
Modification date2018051920180523
UniProtAcc

P78356

Q14974

Ensembl transtripts involved in fusion geneENST00000269554, ENST00000311500, 
ENST00000535458, ENST00000290158, 
ENST00000540627, ENST00000537679, 
ENST00000577918, 
Fusion gene scores* DoF score14 X 9 X 4=5049 X 10 X 5=450
# samples 1510
** MAII scorelog2(15/504*10)=-1.74846123300404
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
log2(10/450*10)=-2.16992500144231
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: PIP4K2B [Title/Abstract] AND KPNB1 [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
TgeneKPNB1

GO:0006606

protein import into nucleus

15964792

TgeneKPNB1

GO:0006610

ribosomal protein import into nucleus

9687515


check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
TCGALDBRCATCGA-BH-A1F2-01APIP4K2Bchr17

36923821

-KPNB1chr17

45757386

+
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
intron-3CDSENST00000269554ENST00000535458PIP4K2Bchr17

36923821

-KPNB1chr17

45757386

+
intron-3CDSENST00000269554ENST00000290158PIP4K2Bchr17

36923821

-KPNB1chr17

45757386

+
intron-3CDSENST00000269554ENST00000540627PIP4K2Bchr17

36923821

-KPNB1chr17

45757386

+
intron-3CDSENST00000269554ENST00000537679PIP4K2Bchr17

36923821

-KPNB1chr17

45757386

+
intron-intronENST00000269554ENST00000577918PIP4K2Bchr17

36923821

-KPNB1chr17

45757386

+
intron-3CDSENST00000311500ENST00000535458PIP4K2Bchr17

36923821

-KPNB1chr17

45757386

+
intron-3CDSENST00000311500ENST00000290158PIP4K2Bchr17

36923821

-KPNB1chr17

45757386

+
intron-3CDSENST00000311500ENST00000540627PIP4K2Bchr17

36923821

-KPNB1chr17

45757386

+
intron-3CDSENST00000311500ENST00000537679PIP4K2Bchr17

36923821

-KPNB1chr17

45757386

+
intron-intronENST00000311500ENST00000577918PIP4K2Bchr17

36923821

-KPNB1chr17

45757386

+

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FusionProtFeatures for PIP4K2B_KPNB1


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
PIP4K2B

P78356

KPNB1

Q14974

Participates in the biosynthesis of phosphatidylinositol4,5-bisphosphate. {ECO:0000269|PubMed:9038203}. Functions in nuclear protein import, either inassociation with an adapter protein, like an importin-alphasubunit, which binds to nuclear localization signals (NLS) incargo substrates, or by acting as autonomous nuclear transportreceptor. Acting autonomously, serves itself as NLS receptor.Docking of the importin/substrate complex to the nuclear porecomplex (NPC) is mediated by KPNB1 through binding to nucleoporinFxFG repeats and the complex is subsequently translocated throughthe pore by an energy requiring, Ran-dependent mechanism. At thenucleoplasmic side of the NPC, Ran binds to importin-beta and thethree components separate and importin-alpha and -beta are re-exported from the nucleus to the cytoplasm where GTP hydrolysisreleases Ran from importin. The directionality of nuclear importis thought to be conferred by an asymmetric distribution of theGTP- and GDP-bound forms of Ran between the cytoplasm and nucleus.Mediates autonomously the nuclear import of ribosomal proteinsRPL23A, RPS7 and RPL5. Binds to a beta-like import receptorbinding (BIB) domain of RPL23A. In association with IPO7 mediatesthe nuclear import of H1 histone. In vitro, mediates nuclearimport of H2A, H2B, H3 and H4 histones. In case of HIV-1infection, binds and mediates the nuclear import of HIV-1 Rev.Imports SNAI1 and PRKCI into the nucleus.{ECO:0000269|PubMed:10228156, ECO:0000269|PubMed:11891849,ECO:0000269|PubMed:19386897, ECO:0000269|PubMed:24699649,ECO:0000269|PubMed:9687515}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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FusionGeneSequence for PIP4K2B_KPNB1


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for PIP4K2B_KPNB1


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors
PIP4K2BTNFRSF1A, PIP4K2B, SPOP, UBQLN4, MED18, CSNK2A2, HMBOX1, ARL6IP4, EAF1, ZRANB2, EPB41L3, LIN7A, DDX23, MYL9, PRPF8, SKP1, MED4, CLK1, CEP19, PIP4K2A, HIF1AN, LZTS2, ARHGAP22, AHCYL2, GPBP1L1, SPRY4, PRICKLE3, ZNF428, TULP3, TMEM194A, SUN2KPNB1SREBF2, KPNA2, NUP153, RANBP2, RANBP1, NUP50, SMAD3, SMAD4, KPNA4, KPNA3, KPNA1, KPNA6, IPO7, IPO8, RUNX1T1, NUP62, NUP54, NUP98, RAN, TERF1, NUTF2, SMN1, PTHLH, LYST, TP53, SNUPN, FGFR1, CDT1, MEPCE, RUVBL2, RUVBL1, MLH1, PMS2, AIRE, PAPOLA, NRIP1, ING1, TPX2, NUP107, MGMT, HIST1H1C, SRY, FAN1, RCC1, MORF4L1, MORF4L2, MRGBP, TERF2, VIMP, KPNB1, AMFR, DERL1, UBC, MYC, PPP2CA, CD4, HDAC5, SPG20, CUL4B, MESDC2, EXO1, RAD21, NFATC1, TUBA1A, NFATC2, ELAVL1, ARRB2, SIRT7, RAPGEF3, CUL3, CDK2, COPS5, CAND1, CHD3, PIAS4, PTN, CD99, NXF1, DCAF8, RAE1, GRK5, NDN, IPO5, KPNA5, HSPA5, IPO9, BARD1, ECT2, MDC1, TP53BP1, NOTCH1, SMURF1, YWHAE, ERBB2, FN1, VCAM1, TAF10, TAF8, TAF3, NOS2, SMAD2, UBL4A, ITGA4, CFTR, AICDA, RASSF5, PTMA, ADRB2, SAMHD1, EGFR, CLK3, NLK, CDK11A, DYRK1B, FBXO6, CUL2, STAU1, HUWE1, FUS, MSL1, CUL7, OBSL1, CCDC8, EED, ITCH, RAC1, ILK, JAK2, NUSAP1, LGALS3, UNK, C11orf58, CSE1L, EXOSC2, IPO4, DIS3, NOP56, RPRD1B, SMC3, NCL, RANBP6, SF3B3, NTRK1, NUP85, LCA5, AHSA1, ALDH3A2, ETF1, GLE1, HADHB, SP110, KIFC1, UBE2I, DLGAP5, NSF, NUP88, RANGAP1, TAF4B, TAF11, SUMO1, RNF113A, NUP214, AAAS, CCNK, NUP155, NUP93, RUSC2, MED24, SLC27A2, NUPL2, NUP205, NUP210, NUP160, TMEM194A, NUP188, KIAA1429, UQCR10, SENP1, CERS2, TMEM214, CEP192, CEP55, SMPD4, NDC1, NUP133, THOC2, CHD8, NUP37, ZC3H14, SEH1L, LCOR, PLEKHA8, TMEM209, SERPINB12, YTHDC1, COMTD1, NUP35, CDCA2, NUP43, RGPD8, POM121C, NUMA1, CRY1, ZNF207, BUB3, MCM2, SNW1, CDC5L, SENP3, POU5F1, U2AF2, FAM204A, BMI1, CTDSPL2, PPM1D, TSR1, B2M, SIX2, HP1BP3, STOM, SENP2, MTNR1A, DLD, DLST, DNM1L, HSD17B10, PDHA1, SDHA, SOAT1, SOD1, VDAC1, G3BP1, BRCA1, MTA2


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for PIP4K2B_KPNB1


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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RelatedDiseases for PIP4K2B_KPNB1


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
TgeneKPNB1C0019693HIV Infections1CTD_human