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Fusion gene ID: 27220 |
FusionGeneSummary for PIK3R4_ASTE1 |
 Fusion gene summary |
| Fusion gene information | Fusion gene name: PIK3R4_ASTE1 | Fusion gene ID: 27220 | Hgene | Tgene | Gene symbol | PIK3R4 | ASTE1 | Gene ID | 30849 | 28990 |
| Gene name | phosphoinositide-3-kinase regulatory subunit 4 | asteroid homolog 1 | |
| Synonyms | VPS15|p150 | HT001 | |
| Cytomap | 3q22.1 | 3q22.1 | |
| Type of gene | protein-coding | protein-coding | |
| Description | phosphoinositide 3-kinase regulatory subunit 4PI3-kinase p150 subunitPI3-kinase regulatory subunit 4phosphatidylinositol 3-kinase-associated p150phosphoinositide 3-kinase adaptor proteinphosphoinositide-3-kinase, regulatory subunit 4, p150 | protein asteroid homolog 1 | |
| Modification date | 20180523 | 20180519 | |
| UniProtAcc | Q99570 | Q2TB18 | |
| Ensembl transtripts involved in fusion gene | ENST00000356763, ENST00000512677, | ENST00000514044, ENST00000264992, | |
| Fusion gene scores | * DoF score | 3 X 3 X 3=27 | 1 X 1 X 1=1 |
| # samples | 3 | 1 | |
| ** MAII score | log2(3/27*10)=0.15200309344505 effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs). DoF>8 and MAII>0 | log2(1/1*10)=3.32192809488736 | |
| Context | PubMed: PIK3R4 [Title/Abstract] AND ASTE1 [Title/Abstract] AND fusion [Title/Abstract] | ||
| Functional or gene categories assigned by FusionGDB annotation | Kinase involved fusion gene, inframe and retained kinase domain. | ||
| * DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
| Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Partner | Gene | GO ID | GO term | PubMed ID |
| Hgene | PIK3R4 | GO:0043552 | positive regulation of phosphatidylinositol 3-kinase activity | 21062745 |
| Fusion gene information from three resources (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| TCGA | RV | STAD | TCGA-CG-4443-01A | PIK3R4 | chr3 | 130447307 | - | ASTE1 | chr3 | 130735183 | - |
| * LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
| Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| In-frame | ENST00000356763 | ENST00000514044 | PIK3R4 | chr3 | 130447307 | - | ASTE1 | chr3 | 130735183 | - |
| In-frame | ENST00000356763 | ENST00000264992 | PIK3R4 | chr3 | 130447307 | - | ASTE1 | chr3 | 130735183 | - |
| intron-3CDS | ENST00000512677 | ENST00000514044 | PIK3R4 | chr3 | 130447307 | - | ASTE1 | chr3 | 130735183 | - |
| intron-3CDS | ENST00000512677 | ENST00000264992 | PIK3R4 | chr3 | 130447307 | - | ASTE1 | chr3 | 130735183 | - |
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FusionProtFeatures for PIK3R4_ASTE1 |
| Main function of each fusion partner protein. (from UniProt) |
| Hgene | Tgene |
| PIK3R4 | ASTE1 |
| Regulatory subunit of the PI3K complex that mediatesformation of phosphatidylinositol 3-phosphate; different complexforms are believed to play a role in multiple membrane traffickingpathways: PI3KC3-C1 is involved in initiation of autophagosomesand PI3KC3-C2 in maturation of autophagosomes and endocytosis.Involved in regulation of degradative endocytic trafficking andcytokinesis, probably in the context of PI3KC3-C2(PubMed:20643123). {ECO:0000269|PubMed:20643123}. | Possible role in EGF receptor signaling. {ECO:0000250}. |
| Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at . * Minus value of BPloci means that the break pointn is located before the CDS. |
| - In-frame and retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
| Hgene | PIK3R4 | chr3:130447307 | chr3:130735183 | ENST00000356763 | - | 6 | 20 | 26_324 | 602 | 1359 | Domain | Protein kinase |
| Hgene | PIK3R4 | chr3:130447307 | chr3:130735183 | ENST00000356763 | - | 6 | 20 | 32_40 | 602 | 1359 | Nucleotide binding | ATP |
| Hgene | PIK3R4 | chr3:130447307 | chr3:130735183 | ENST00000356763 | - | 6 | 20 | 413_450 | 602 | 1359 | Repeat | Note=HEAT 1 |
| Hgene | PIK3R4 | chr3:130447307 | chr3:130735183 | ENST00000356763 | - | 6 | 20 | 458_495 | 602 | 1359 | Repeat | Note=HEAT 2 |
| - In-frame and not-retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
| Hgene | >PIK3R4 | chr3:130447307 | chr3:130735183 | ENST00000356763 | - | 6 | 20 | 781_784 | 602 | 1359 | Compositional bias | Note=Poly-Glu |
| Hgene | >PIK3R4 | chr3:130447307 | chr3:130735183 | ENST00000356763 | - | 6 | 20 | 974_977 | 602 | 1359 | Compositional bias | Note=Poly-Pro |
| Hgene | >PIK3R4 | chr3:130447307 | chr3:130735183 | ENST00000356763 | - | 6 | 20 | 1040_1079 | 602 | 1359 | Repeat | Note=WD 2 |
| Hgene | >PIK3R4 | chr3:130447307 | chr3:130735183 | ENST00000356763 | - | 6 | 20 | 1093_1134 | 602 | 1359 | Repeat | Note=WD 3 |
| Hgene | >PIK3R4 | chr3:130447307 | chr3:130735183 | ENST00000356763 | - | 6 | 20 | 1139_1178 | 602 | 1359 | Repeat | Note=WD 4 |
| Hgene | >PIK3R4 | chr3:130447307 | chr3:130735183 | ENST00000356763 | - | 6 | 20 | 1182_1223 | 602 | 1359 | Repeat | Note=WD 5 |
| Hgene | >PIK3R4 | chr3:130447307 | chr3:130735183 | ENST00000356763 | - | 6 | 20 | 1237_1278 | 602 | 1359 | Repeat | Note=WD 6 |
| Hgene | >PIK3R4 | chr3:130447307 | chr3:130735183 | ENST00000356763 | - | 6 | 20 | 1327_1358 | 602 | 1359 | Repeat | Note=WD 7 |
| Hgene | >PIK3R4 | chr3:130447307 | chr3:130735183 | ENST00000356763 | - | 6 | 20 | 572_610 | 602 | 1359 | Repeat | Note=HEAT 3 |
| Hgene | >PIK3R4 | chr3:130447307 | chr3:130735183 | ENST00000356763 | - | 6 | 20 | 991_1030 | 602 | 1359 | Repeat | Note=WD 1 |
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FusionGeneSequence for PIK3R4_ASTE1 |
| For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. (nt: nucleotides, aa: amino acids) |
| * Fusion amino acid sequences. |
| >In-frame_PIK3R4_ENST00000356763_chr3_130447307_-_ASTE1_ENST00000514044_chr3_130735183_-_803aa MGNQLAGIAPSQILSVESYFSDIHDFEYDKSLGSTRFFKVARAKHREGLVVVKVFAIQDPTLPLTSYKQELEELKIRLNSAQNCLPFQKA SEKASEKAAMLFRQYVRDNLYDRISTRPFLNNIEKRWIAFQILTAVDQAHKSGVRHGDIKTENVMVTSWNWVLLTDFASFKPTYLPEDNP ADFNYFFDTSRRRTCYIAPERFVDGGMFATELEYMRDPSTPLVDLNSNQRTRGELKRAMDIFSAGCVIAELFTEGVPLFDLSQLLAYRNG HFFPEQVLNKIEDHSIRELVTQMIHREPDKRLEAEDYLKQQRGNAFPEIFYTFLQPYMAQFAKETFLSADERILVIRKDLGNIIHNLCGH DLPEKAEGEPKENGLVILVSVITSCLQTLKYCDSKLAALELILHLAPRLSVEILLDRITPYLLHFSNDSVPRVRAEALRTLTKVLALVKE VPRNDINIYPEYILPGIAHLAQDDATIVRLAYAENIALLAETALRFLELVQLKNLNMENDPNNEEIDEVTHPNGNYDTELQALHEMVQQK VVTLLSDPENIVKQTLMENGITRLCVFFGRQKANDVLLSHMITFLNDKNDWHLRGAFFDSIVGKEELQEDGAKMLYAEFQRVKAQTRLGT RLDLDTAHIFCQWQSCLQMGMYLNQLLSTPLPEPDLTRPSAFNTLNEDIWTHTKYGGTLHVSRLYSGSLVHGLCQQLLASTSVESLLSIC >In-frame_PIK3R4_ENST00000356763_chr3_130447307_-_ASTE1_ENST00000264992_chr3_130735183_-_778aa MGNQLAGIAPSQILSVESYFSDIHDFEYDKSLGSTRFFKVARAKHREGLVVVKVFAIQDPTLPLTSYKQELEELKIRLNSAQNCLPFQKA SEKASEKAAMLFRQYVRDNLYDRISTRPFLNNIEKRWIAFQILTAVDQAHKSGVRHGDIKTENVMVTSWNWVLLTDFASFKPTYLPEDNP ADFNYFFDTSRRRTCYIAPERFVDGGMFATELEYMRDPSTPLVDLNSNQRTRGELKRAMDIFSAGCVIAELFTEGVPLFDLSQLLAYRNG HFFPEQVLNKIEDHSIRELVTQMIHREPDKRLEAEDYLKQQRGNAFPEIFYTFLQPYMAQFAKETFLSADERILVIRKDLGNIIHNLCGH DLPEKAEGEPKENGLVILVSVITSCLQTLKYCDSKLAALELILHLAPRLSVEILLDRITPYLLHFSNDSVPRVRAEALRTLTKVLALVKE VPRNDINIYPEYILPGIAHLAQDDATIVRLAYAENIALLAETALRFLELVQLKNLNMENDPNNEEIDEVTHPNGNYDTELQALHEMVQQK VVTLLSDPENIVKQTLMENGITRLCVFFGRQKANDVLLSHMITFLNDKNDWHLRGAFFDSIVGKEELQEDGAKMLYAEFQRVKAQTRLGT RLDLDTAHIFCQWQSCLQMGMYLNQLLSTPLPEPDLTRLYSGSLVHGLCQQLLASTSVESLLSICPEAKQLYEYLFNATRSYAPAEIFLP |
| * Fusion transcript sequences (only coding sequence (CDS) region). |
| >In-frame_PIK3R4_ENST00000356763_chr3_130447307_-_ASTE1_ENST00000514044_chr3_130735183_-_2409nt ATGGGAAATCAGCTTGCTGGCATTGCTCCCTCCCAGATCCTTTCTGTAGAGAGTTATTTTTCAGATATTCATGACTTTGAATATGATAAA AGCCTGGGGAGTACTCGGTTTTTTAAAGTTGCTCGAGCCAAGCACCGAGAAGGCCTGGTCGTTGTGAAGGTTTTTGCAATTCAGGATCCC ACATTGCCTTTAACCAGCTATAAACAAGAGCTGGAGGAACTGAAAATCAGGCTTAATTCTGCACAGAATTGTCTACCTTTCCAGAAAGCA TCAGAAAAAGCATCTGAGAAAGCAGCTATGCTCTTTAGGCAGTATGTGCGAGACAATCTCTATGATCGCATCAGTACCCGTCCATTCTTG AATAACATTGAGAAGCGCTGGATTGCTTTCCAGATCCTGACAGCTGTGGACCAAGCACACAAATCTGGAGTTCGTCATGGGGACATCAAG ACTGAGAATGTGATGGTCACCAGTTGGAATTGGGTTCTTCTAACTGATTTTGCCAGTTTTAAGCCCACTTATCTTCCAGAAGACAACCCG GCAGATTTCAATTATTTCTTTGACACATCACGGAGGAGAACTTGCTATATTGCTCCTGAACGTTTTGTTGATGGTGGGATGTTTGCCACT GAGTTAGAATATATGAGAGATCCTTCAACTCCGCTTGTAGACTTAAATAGCAATCAGAGAACAAGAGGAGAGTTGAAGAGAGCAATGGAC ATCTTTTCAGCAGGTTGTGTGATAGCTGAGCTTTTTACAGAAGGTGTACCATTATTTGATCTCTCTCAACTTTTGGCTTATAGAAATGGA CATTTTTTCCCTGAACAAGTGCTAAATAAAATTGAAGATCACAGTATCAGAGAATTGGTAACTCAGATGATTCACCGTGAGCCAGATAAA CGTTTAGAGGCAGAAGATTACTTAAAACAGCAGCGTGGCAATGCCTTTCCTGAAATATTTTACACTTTTCTTCAGCCCTACATGGCCCAG TTTGCCAAGGAAACGTTTCTTTCTGCAGATGAGCGTATTCTGGTTATACGGAAGGATTTGGGCAACATTATTCACAATCTCTGTGGACAT GATCTGCCAGAAAAAGCCGAAGGAGAGCCTAAGGAAAATGGGCTGGTTATCTTGGTATCTGTTATAACATCCTGCCTACAGACCCTTAAA TACTGTGATTCCAAACTAGCTGCTTTGGAACTGATTCTTCATTTGGCTCCAAGATTAAGTGTTGAAATCCTTTTGGATCGTATTACTCCA TATCTTTTGCATTTCAGCAATGACTCTGTTCCTAGGGTGAGGGCTGAAGCCTTGAGGACGTTGACCAAAGTTCTTGCTCTCGTCAAAGAG GTTCCTCGTAATGATATCAATATTTATCCGGAATACATTCTGCCAGGCATAGCCCACTTAGCCCAAGATGATGCTACTATCGTTAGACTA GCCTATGCTGAAAACATAGCTCTGCTGGCAGAAACAGCTCTGAGATTCCTGGAATTAGTACAGTTAAAAAATCTTAATATGGAAAATGAC CCCAATAATGAAGAAATAGATGAGGTTACACATCCAAATGGAAATTATGACACAGAGCTCCAAGCCTTACATGAAATGGTCCAGCAGAAA GTTGTTACTTTGCTAAGTGACCCTGAAAATATTGTAAAACAAACCTTGATGGAAAATGGAATAACACGGCTGTGTGTATTCTTTGGACGT CAGAAAGCCAACGATGTTTTGTTGTCCCACATGATTACTTTCCTAAATGATAAGAATGATTGGCATCTACGTGGAGCATTTTTTGATAGT ATAGTTGGTAAGGAAGAGCTGCAGGAAGATGGTGCTAAGATGTTGTATGCAGAGTTCCAAAGAGTGAAGGCGCAGACACGGCTGGGCACA AGACTGGACTTAGACACAGCTCACATCTTCTGTCAGTGGCAGTCCTGTCTCCAGATGGGGATGTATCTCAACCAGCTGCTGTCCACTCCT CTCCCAGAGCCAGACCTAACTCGCCCCAGTGCCTTCAATACTTTGAATGAGGATATATGGACGCATACAAAATATGGTGGGACTTTACAT GTTTCAAGACTGTACAGTGGAAGCCTGGTGCACGGACTATGCCAGCAACTGCTAGCATCGACCTCTGTAGAAAGTCTCCTGAGCATATGT CCTGAGGCTAAGCAACTTTATGAATATCTATTCAATGCCACAAGGTCATATGCCCCCGCTGAAATATTCCTACCAAAAGGTAGATCAAAT TCAAAAAAAAAAAGGCAGAAGAAACAGAATACCAGCTGTTCTAAGAACAGAGGGAGAACCACTGCACACACCAAGTGTTGGTATGAGGGA >In-frame_PIK3R4_ENST00000356763_chr3_130447307_-_ASTE1_ENST00000264992_chr3_130735183_-_2334nt ATGGGAAATCAGCTTGCTGGCATTGCTCCCTCCCAGATCCTTTCTGTAGAGAGTTATTTTTCAGATATTCATGACTTTGAATATGATAAA AGCCTGGGGAGTACTCGGTTTTTTAAAGTTGCTCGAGCCAAGCACCGAGAAGGCCTGGTCGTTGTGAAGGTTTTTGCAATTCAGGATCCC ACATTGCCTTTAACCAGCTATAAACAAGAGCTGGAGGAACTGAAAATCAGGCTTAATTCTGCACAGAATTGTCTACCTTTCCAGAAAGCA TCAGAAAAAGCATCTGAGAAAGCAGCTATGCTCTTTAGGCAGTATGTGCGAGACAATCTCTATGATCGCATCAGTACCCGTCCATTCTTG AATAACATTGAGAAGCGCTGGATTGCTTTCCAGATCCTGACAGCTGTGGACCAAGCACACAAATCTGGAGTTCGTCATGGGGACATCAAG ACTGAGAATGTGATGGTCACCAGTTGGAATTGGGTTCTTCTAACTGATTTTGCCAGTTTTAAGCCCACTTATCTTCCAGAAGACAACCCG GCAGATTTCAATTATTTCTTTGACACATCACGGAGGAGAACTTGCTATATTGCTCCTGAACGTTTTGTTGATGGTGGGATGTTTGCCACT GAGTTAGAATATATGAGAGATCCTTCAACTCCGCTTGTAGACTTAAATAGCAATCAGAGAACAAGAGGAGAGTTGAAGAGAGCAATGGAC ATCTTTTCAGCAGGTTGTGTGATAGCTGAGCTTTTTACAGAAGGTGTACCATTATTTGATCTCTCTCAACTTTTGGCTTATAGAAATGGA CATTTTTTCCCTGAACAAGTGCTAAATAAAATTGAAGATCACAGTATCAGAGAATTGGTAACTCAGATGATTCACCGTGAGCCAGATAAA CGTTTAGAGGCAGAAGATTACTTAAAACAGCAGCGTGGCAATGCCTTTCCTGAAATATTTTACACTTTTCTTCAGCCCTACATGGCCCAG TTTGCCAAGGAAACGTTTCTTTCTGCAGATGAGCGTATTCTGGTTATACGGAAGGATTTGGGCAACATTATTCACAATCTCTGTGGACAT GATCTGCCAGAAAAAGCCGAAGGAGAGCCTAAGGAAAATGGGCTGGTTATCTTGGTATCTGTTATAACATCCTGCCTACAGACCCTTAAA TACTGTGATTCCAAACTAGCTGCTTTGGAACTGATTCTTCATTTGGCTCCAAGATTAAGTGTTGAAATCCTTTTGGATCGTATTACTCCA TATCTTTTGCATTTCAGCAATGACTCTGTTCCTAGGGTGAGGGCTGAAGCCTTGAGGACGTTGACCAAAGTTCTTGCTCTCGTCAAAGAG GTTCCTCGTAATGATATCAATATTTATCCGGAATACATTCTGCCAGGCATAGCCCACTTAGCCCAAGATGATGCTACTATCGTTAGACTA GCCTATGCTGAAAACATAGCTCTGCTGGCAGAAACAGCTCTGAGATTCCTGGAATTAGTACAGTTAAAAAATCTTAATATGGAAAATGAC CCCAATAATGAAGAAATAGATGAGGTTACACATCCAAATGGAAATTATGACACAGAGCTCCAAGCCTTACATGAAATGGTCCAGCAGAAA GTTGTTACTTTGCTAAGTGACCCTGAAAATATTGTAAAACAAACCTTGATGGAAAATGGAATAACACGGCTGTGTGTATTCTTTGGACGT CAGAAAGCCAACGATGTTTTGTTGTCCCACATGATTACTTTCCTAAATGATAAGAATGATTGGCATCTACGTGGAGCATTTTTTGATAGT ATAGTTGGTAAGGAAGAGCTGCAGGAAGATGGTGCTAAGATGTTGTATGCAGAGTTCCAAAGAGTGAAGGCGCAGACACGGCTGGGCACA AGACTGGACTTAGACACAGCTCACATCTTCTGTCAGTGGCAGTCCTGTCTCCAGATGGGGATGTATCTCAACCAGCTGCTGTCCACTCCT CTCCCAGAGCCAGACCTAACTCGACTGTACAGTGGAAGCCTGGTGCACGGACTATGCCAGCAACTGCTAGCATCGACCTCTGTAGAAAGT CTCCTGAGCATATGTCCTGAGGCTAAGCAACTTTATGAATATCTATTCAATGCCACAAGGTCATATGCCCCCGCTGAAATATTCCTACCA AAAGGTAGATCAAATTCAAAAAAAAAAAGGCAGAAGAAACAGAATACCAGCTGTTCTAAGAACAGAGGGAGAACCACTGCACACACCAAG |
| * Fusion transcript sequences (Full-length transcript). |
| >In-frame_PIK3R4_ENST00000356763_chr3_130447307_-_ASTE1_ENST00000514044_chr3_130735183_-_3149nt GAGGTCAGACCGGTTGCTTTCCCGGGAGTTCGGCGTTTGCTGGGGCTGCAGCAGCTGAAGTGTAGTGTTTTCTTGGGACTGGCGGTCTGC ACTTCTCTCCCGGGTTCCATCTCCCCCCGCCCGGTGGTGAGGCCCTCGAGGAGGGCTCGGACGGGTGTAGCGATCCGCGCTAGAGGAAGA CGAGGCCCGGGAACGCATGTCCCCCAGGGCAGGTTAGGGGGCTGGAGGGGTCAAATCCCGGGGTACTTGTGGAGACTCTTTAGCGTGGCT TCTTCTCTCTGCTGAGACCCCGAGAGCTTTCCCAGTTCTCCTCCCAGGACCACCGGGGTTCCTGAAGATCGGGACTTTTCTGCGCCCCTC CACCAACAGCCCATCTCCTGTCTATGAAGAAAGACCCTTCGTAGAAACAACTTCCCCGCTGCTGACGCGTTTTCCCGTCCCGTCCCCGAA GTAGTCTACTATGACCTCGTTGTGAGCCTCTGAACGATTTTGACACTTTCCCGAGGCCTAGGGTATTATATCCTAACCTTACTAAAGACC ACAGAGGTGCTTGCCATTATGGGAAATCAGCTTGCTGGCATTGCTCCCTCCCAGATCCTTTCTGTAGAGAGTTATTTTTCAGATATTCAT GACTTTGAATATGATAAAAGCCTGGGGAGTACTCGGTTTTTTAAAGTTGCTCGAGCCAAGCACCGAGAAGGCCTGGTCGTTGTGAAGGTT TTTGCAATTCAGGATCCCACATTGCCTTTAACCAGCTATAAACAAGAGCTGGAGGAACTGAAAATCAGGCTTAATTCTGCACAGAATTGT CTACCTTTCCAGAAAGCATCAGAAAAAGCATCTGAGAAAGCAGCTATGCTCTTTAGGCAGTATGTGCGAGACAATCTCTATGATCGCATC AGTACCCGTCCATTCTTGAATAACATTGAGAAGCGCTGGATTGCTTTCCAGATCCTGACAGCTGTGGACCAAGCACACAAATCTGGAGTT CGTCATGGGGACATCAAGACTGAGAATGTGATGGTCACCAGTTGGAATTGGGTTCTTCTAACTGATTTTGCCAGTTTTAAGCCCACTTAT CTTCCAGAAGACAACCCGGCAGATTTCAATTATTTCTTTGACACATCACGGAGGAGAACTTGCTATATTGCTCCTGAACGTTTTGTTGAT GGTGGGATGTTTGCCACTGAGTTAGAATATATGAGAGATCCTTCAACTCCGCTTGTAGACTTAAATAGCAATCAGAGAACAAGAGGAGAG TTGAAGAGAGCAATGGACATCTTTTCAGCAGGTTGTGTGATAGCTGAGCTTTTTACAGAAGGTGTACCATTATTTGATCTCTCTCAACTT TTGGCTTATAGAAATGGACATTTTTTCCCTGAACAAGTGCTAAATAAAATTGAAGATCACAGTATCAGAGAATTGGTAACTCAGATGATT CACCGTGAGCCAGATAAACGTTTAGAGGCAGAAGATTACTTAAAACAGCAGCGTGGCAATGCCTTTCCTGAAATATTTTACACTTTTCTT CAGCCCTACATGGCCCAGTTTGCCAAGGAAACGTTTCTTTCTGCAGATGAGCGTATTCTGGTTATACGGAAGGATTTGGGCAACATTATT CACAATCTCTGTGGACATGATCTGCCAGAAAAAGCCGAAGGAGAGCCTAAGGAAAATGGGCTGGTTATCTTGGTATCTGTTATAACATCC TGCCTACAGACCCTTAAATACTGTGATTCCAAACTAGCTGCTTTGGAACTGATTCTTCATTTGGCTCCAAGATTAAGTGTTGAAATCCTT TTGGATCGTATTACTCCATATCTTTTGCATTTCAGCAATGACTCTGTTCCTAGGGTGAGGGCTGAAGCCTTGAGGACGTTGACCAAAGTT CTTGCTCTCGTCAAAGAGGTTCCTCGTAATGATATCAATATTTATCCGGAATACATTCTGCCAGGCATAGCCCACTTAGCCCAAGATGAT GCTACTATCGTTAGACTAGCCTATGCTGAAAACATAGCTCTGCTGGCAGAAACAGCTCTGAGATTCCTGGAATTAGTACAGTTAAAAAAT CTTAATATGGAAAATGACCCCAATAATGAAGAAATAGATGAGGTTACACATCCAAATGGAAATTATGACACAGAGCTCCAAGCCTTACAT GAAATGGTCCAGCAGAAAGTTGTTACTTTGCTAAGTGACCCTGAAAATATTGTAAAACAAACCTTGATGGAAAATGGAATAACACGGCTG TGTGTATTCTTTGGACGTCAGAAAGCCAACGATGTTTTGTTGTCCCACATGATTACTTTCCTAAATGATAAGAATGATTGGCATCTACGT GGAGCATTTTTTGATAGTATAGTTGGTAAGGAAGAGCTGCAGGAAGATGGTGCTAAGATGTTGTATGCAGAGTTCCAAAGAGTGAAGGCG CAGACACGGCTGGGCACAAGACTGGACTTAGACACAGCTCACATCTTCTGTCAGTGGCAGTCCTGTCTCCAGATGGGGATGTATCTCAAC CAGCTGCTGTCCACTCCTCTCCCAGAGCCAGACCTAACTCGCCCCAGTGCCTTCAATACTTTGAATGAGGATATATGGACGCATACAAAA TATGGTGGGACTTTACATGTTTCAAGACTGTACAGTGGAAGCCTGGTGCACGGACTATGCCAGCAACTGCTAGCATCGACCTCTGTAGAA AGTCTCCTGAGCATATGTCCTGAGGCTAAGCAACTTTATGAATATCTATTCAATGCCACAAGGTCATATGCCCCCGCTGAAATATTCCTA CCAAAAGGTAGATCAAATTCAAAAAAAAAAAGGCAGAAGAAACAGAATACCAGCTGTTCTAAGAACAGAGGGAGAACCACTGCACACACC AAGTGTTGGTATGAGGGAAACAACCGGTTTGGGTTGTTAATGGTTGAAAACTTAGAGGAACATAGTGAGGCCTCCAACATTGAATAAAAC TCAGTTTGCATCAAACTAGATGTATTTAATATAATCCTTACTTAAAATTCTTCCGTTACCACCCTTGAAACAATTAGCTTTTTCTTTAGG >In-frame_PIK3R4_ENST00000356763_chr3_130447307_-_ASTE1_ENST00000264992_chr3_130735183_-_3074nt GAGGTCAGACCGGTTGCTTTCCCGGGAGTTCGGCGTTTGCTGGGGCTGCAGCAGCTGAAGTGTAGTGTTTTCTTGGGACTGGCGGTCTGC ACTTCTCTCCCGGGTTCCATCTCCCCCCGCCCGGTGGTGAGGCCCTCGAGGAGGGCTCGGACGGGTGTAGCGATCCGCGCTAGAGGAAGA CGAGGCCCGGGAACGCATGTCCCCCAGGGCAGGTTAGGGGGCTGGAGGGGTCAAATCCCGGGGTACTTGTGGAGACTCTTTAGCGTGGCT TCTTCTCTCTGCTGAGACCCCGAGAGCTTTCCCAGTTCTCCTCCCAGGACCACCGGGGTTCCTGAAGATCGGGACTTTTCTGCGCCCCTC CACCAACAGCCCATCTCCTGTCTATGAAGAAAGACCCTTCGTAGAAACAACTTCCCCGCTGCTGACGCGTTTTCCCGTCCCGTCCCCGAA GTAGTCTACTATGACCTCGTTGTGAGCCTCTGAACGATTTTGACACTTTCCCGAGGCCTAGGGTATTATATCCTAACCTTACTAAAGACC ACAGAGGTGCTTGCCATTATGGGAAATCAGCTTGCTGGCATTGCTCCCTCCCAGATCCTTTCTGTAGAGAGTTATTTTTCAGATATTCAT GACTTTGAATATGATAAAAGCCTGGGGAGTACTCGGTTTTTTAAAGTTGCTCGAGCCAAGCACCGAGAAGGCCTGGTCGTTGTGAAGGTT TTTGCAATTCAGGATCCCACATTGCCTTTAACCAGCTATAAACAAGAGCTGGAGGAACTGAAAATCAGGCTTAATTCTGCACAGAATTGT CTACCTTTCCAGAAAGCATCAGAAAAAGCATCTGAGAAAGCAGCTATGCTCTTTAGGCAGTATGTGCGAGACAATCTCTATGATCGCATC AGTACCCGTCCATTCTTGAATAACATTGAGAAGCGCTGGATTGCTTTCCAGATCCTGACAGCTGTGGACCAAGCACACAAATCTGGAGTT CGTCATGGGGACATCAAGACTGAGAATGTGATGGTCACCAGTTGGAATTGGGTTCTTCTAACTGATTTTGCCAGTTTTAAGCCCACTTAT CTTCCAGAAGACAACCCGGCAGATTTCAATTATTTCTTTGACACATCACGGAGGAGAACTTGCTATATTGCTCCTGAACGTTTTGTTGAT GGTGGGATGTTTGCCACTGAGTTAGAATATATGAGAGATCCTTCAACTCCGCTTGTAGACTTAAATAGCAATCAGAGAACAAGAGGAGAG TTGAAGAGAGCAATGGACATCTTTTCAGCAGGTTGTGTGATAGCTGAGCTTTTTACAGAAGGTGTACCATTATTTGATCTCTCTCAACTT TTGGCTTATAGAAATGGACATTTTTTCCCTGAACAAGTGCTAAATAAAATTGAAGATCACAGTATCAGAGAATTGGTAACTCAGATGATT CACCGTGAGCCAGATAAACGTTTAGAGGCAGAAGATTACTTAAAACAGCAGCGTGGCAATGCCTTTCCTGAAATATTTTACACTTTTCTT CAGCCCTACATGGCCCAGTTTGCCAAGGAAACGTTTCTTTCTGCAGATGAGCGTATTCTGGTTATACGGAAGGATTTGGGCAACATTATT CACAATCTCTGTGGACATGATCTGCCAGAAAAAGCCGAAGGAGAGCCTAAGGAAAATGGGCTGGTTATCTTGGTATCTGTTATAACATCC TGCCTACAGACCCTTAAATACTGTGATTCCAAACTAGCTGCTTTGGAACTGATTCTTCATTTGGCTCCAAGATTAAGTGTTGAAATCCTT TTGGATCGTATTACTCCATATCTTTTGCATTTCAGCAATGACTCTGTTCCTAGGGTGAGGGCTGAAGCCTTGAGGACGTTGACCAAAGTT CTTGCTCTCGTCAAAGAGGTTCCTCGTAATGATATCAATATTTATCCGGAATACATTCTGCCAGGCATAGCCCACTTAGCCCAAGATGAT GCTACTATCGTTAGACTAGCCTATGCTGAAAACATAGCTCTGCTGGCAGAAACAGCTCTGAGATTCCTGGAATTAGTACAGTTAAAAAAT CTTAATATGGAAAATGACCCCAATAATGAAGAAATAGATGAGGTTACACATCCAAATGGAAATTATGACACAGAGCTCCAAGCCTTACAT GAAATGGTCCAGCAGAAAGTTGTTACTTTGCTAAGTGACCCTGAAAATATTGTAAAACAAACCTTGATGGAAAATGGAATAACACGGCTG TGTGTATTCTTTGGACGTCAGAAAGCCAACGATGTTTTGTTGTCCCACATGATTACTTTCCTAAATGATAAGAATGATTGGCATCTACGT GGAGCATTTTTTGATAGTATAGTTGGTAAGGAAGAGCTGCAGGAAGATGGTGCTAAGATGTTGTATGCAGAGTTCCAAAGAGTGAAGGCG CAGACACGGCTGGGCACAAGACTGGACTTAGACACAGCTCACATCTTCTGTCAGTGGCAGTCCTGTCTCCAGATGGGGATGTATCTCAAC CAGCTGCTGTCCACTCCTCTCCCAGAGCCAGACCTAACTCGACTGTACAGTGGAAGCCTGGTGCACGGACTATGCCAGCAACTGCTAGCA TCGACCTCTGTAGAAAGTCTCCTGAGCATATGTCCTGAGGCTAAGCAACTTTATGAATATCTATTCAATGCCACAAGGTCATATGCCCCC GCTGAAATATTCCTACCAAAAGGTAGATCAAATTCAAAAAAAAAAAGGCAGAAGAAACAGAATACCAGCTGTTCTAAGAACAGAGGGAGA ACCACTGCACACACCAAGTGTTGGTATGAGGGAAACAACCGGTTTGGGTTGTTAATGGTTGAAAACTTAGAGGAACATAGTGAGGCCTCC AACATTGAATAAAACTCAGTTTGCATCAAACTAGATGTATTTAATATAATCCTTACTTAAAATTCTTCCGTTACCACCCTTGAAACAATT AGCTTTTTCTTTAGGACTGACCTGTTAGGGGATAAACATCACAATAATCTGAATTCCAAGTTATTTTGTATTTTGTTTTTAATAAATACA |
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FusionGenePPI for PIK3R4_ASTE1 |
| Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in . |
| Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160) |
| Hgene | Hgene's interactors | Tgene | Tgene's interactors |
| PIK3R4 | BECN1, ATG14, MAP1LC3C, PIK3C3, UVRAG, YWHAB, KRIT1, YWHAE, KIAA0226, MOV10, NXF1, NRBF2, JADE2, NTRK1, XPO1, XRCC3, FGFR1OP, PARD6A, SNW1, DVL2, KIAA0226L | ASTE1 | HECW2, XRCC4, CDC42, CDK2, MYH11, KIF20B, ZWINT, GOLT1B, GAR1, TMEM248, NABP1, USP47, EPS8L2, ZNF692 |
| - Retained PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
| - Lost PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
| - Retained PPIs, but lost function due to frame-shift fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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RelatedDrugs for PIK3R4_ASTE1 |
| Drugs targeting genes involved in this fusion gene. (DrugBank Version 5.1.0 2018-04-02) |
| Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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RelatedDiseases for PIK3R4_ASTE1 |
| Diseases associated with fusion partners. (DisGeNet 4.0) |
| Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
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