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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 27215

FusionGeneSummary for PIK3R3_MOB3C

check button Fusion gene summary
Fusion gene informationFusion gene name: PIK3R3_MOB3C
Fusion gene ID: 27215
HgeneTgene
Gene symbol

PIK3R3

MOB3C

Gene ID

8503

148932

Gene namephosphoinositide-3-kinase regulatory subunit 3MOB kinase activator 3C
Synonymsp55|p55-GAMMA|p55PIKMOB1E|MOBKL2C
Cytomap

1p34.1

1p33

Type of geneprotein-codingprotein-coding
Descriptionphosphatidylinositol 3-kinase regulatory subunit gammaPI3-kinase regulatory subunit gammaPI3-kinase subunit p55-gammaPI3K regulatory subunit gammaphosphatidylinositol 3-kinase 55 kDa regulatory subunit gammaphosphatidylinositol 3-kinase, regulatory sMOB kinase activator 3CMOB1, Mps One Binder kinase activator-like 2Cmob1 homolog 2C
Modification date2018052320180519
UniProtAcc

Q92569

Q70IA8

Ensembl transtripts involved in fusion geneENST00000262741, ENST00000372006, 
ENST00000340332, ENST00000420542, 
ENST00000354242, ENST00000540385, 
ENST00000423209, ENST00000488808, 
ENST00000319928, ENST00000271139, 
ENST00000371940, ENST00000477318, 
Fusion gene scores* DoF score6 X 5 X 6=1803 X 2 X 3=18
# samples 83
** MAII scorelog2(8/180*10)=-1.16992500144231
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
log2(3/18*10)=0.736965594166206
effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs).
DoF>8 and MAII>0
Context

PubMed: PIK3R3 [Title/Abstract] AND MOB3C [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID

check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
TCGALDCESCTCGA-VS-A9V0-01APIK3R3chr1

46543187

-MOB3Cchr1

47079043

-
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
5CDS-5UTRENST00000262741ENST00000319928PIK3R3chr1

46543187

-MOB3Cchr1

47079043

-
5CDS-5UTRENST00000262741ENST00000271139PIK3R3chr1

46543187

-MOB3Cchr1

47079043

-
5CDS-5UTRENST00000262741ENST00000371940PIK3R3chr1

46543187

-MOB3Cchr1

47079043

-
5CDS-5UTRENST00000262741ENST00000477318PIK3R3chr1

46543187

-MOB3Cchr1

47079043

-
5CDS-5UTRENST00000372006ENST00000319928PIK3R3chr1

46543187

-MOB3Cchr1

47079043

-
5CDS-5UTRENST00000372006ENST00000271139PIK3R3chr1

46543187

-MOB3Cchr1

47079043

-
5CDS-5UTRENST00000372006ENST00000371940PIK3R3chr1

46543187

-MOB3Cchr1

47079043

-
5CDS-5UTRENST00000372006ENST00000477318PIK3R3chr1

46543187

-MOB3Cchr1

47079043

-
5CDS-5UTRENST00000340332ENST00000319928PIK3R3chr1

46543187

-MOB3Cchr1

47079043

-
5CDS-5UTRENST00000340332ENST00000271139PIK3R3chr1

46543187

-MOB3Cchr1

47079043

-
5CDS-5UTRENST00000340332ENST00000371940PIK3R3chr1

46543187

-MOB3Cchr1

47079043

-
5CDS-5UTRENST00000340332ENST00000477318PIK3R3chr1

46543187

-MOB3Cchr1

47079043

-
5CDS-5UTRENST00000420542ENST00000319928PIK3R3chr1

46543187

-MOB3Cchr1

47079043

-
5CDS-5UTRENST00000420542ENST00000271139PIK3R3chr1

46543187

-MOB3Cchr1

47079043

-
5CDS-5UTRENST00000420542ENST00000371940PIK3R3chr1

46543187

-MOB3Cchr1

47079043

-
5CDS-5UTRENST00000420542ENST00000477318PIK3R3chr1

46543187

-MOB3Cchr1

47079043

-
5CDS-5UTRENST00000354242ENST00000319928PIK3R3chr1

46543187

-MOB3Cchr1

47079043

-
5CDS-5UTRENST00000354242ENST00000271139PIK3R3chr1

46543187

-MOB3Cchr1

47079043

-
5CDS-5UTRENST00000354242ENST00000371940PIK3R3chr1

46543187

-MOB3Cchr1

47079043

-
5CDS-5UTRENST00000354242ENST00000477318PIK3R3chr1

46543187

-MOB3Cchr1

47079043

-
5CDS-5UTRENST00000540385ENST00000319928PIK3R3chr1

46543187

-MOB3Cchr1

47079043

-
5CDS-5UTRENST00000540385ENST00000271139PIK3R3chr1

46543187

-MOB3Cchr1

47079043

-
5CDS-5UTRENST00000540385ENST00000371940PIK3R3chr1

46543187

-MOB3Cchr1

47079043

-
5CDS-5UTRENST00000540385ENST00000477318PIK3R3chr1

46543187

-MOB3Cchr1

47079043

-
5CDS-5UTRENST00000423209ENST00000319928PIK3R3chr1

46543187

-MOB3Cchr1

47079043

-
5CDS-5UTRENST00000423209ENST00000271139PIK3R3chr1

46543187

-MOB3Cchr1

47079043

-
5CDS-5UTRENST00000423209ENST00000371940PIK3R3chr1

46543187

-MOB3Cchr1

47079043

-
5CDS-5UTRENST00000423209ENST00000477318PIK3R3chr1

46543187

-MOB3Cchr1

47079043

-
intron-5UTRENST00000488808ENST00000319928PIK3R3chr1

46543187

-MOB3Cchr1

47079043

-
intron-5UTRENST00000488808ENST00000271139PIK3R3chr1

46543187

-MOB3Cchr1

47079043

-
intron-5UTRENST00000488808ENST00000371940PIK3R3chr1

46543187

-MOB3Cchr1

47079043

-
intron-5UTRENST00000488808ENST00000477318PIK3R3chr1

46543187

-MOB3Cchr1

47079043

-

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FusionProtFeatures for PIK3R3_MOB3C


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
PIK3R3

Q92569

MOB3C

Q70IA8

Binds to activated (phosphorylated) protein-tyrosinekinases through its SH2 domain and regulates their kinaseactivity. During insulin stimulation, it also binds to IRS-1. May regulate the activity of kinases. {ECO:0000250}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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FusionGeneSequence for PIK3R3_MOB3C


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for PIK3R3_MOB3C


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors
PIK3R3PIK3CA, DRAP1, RB1, IRS2, IRS1, IGF1R, ABCB6, RING1, AMBP, ORM1, SERF1A, GC, KARS, MICAL1, DSN1, VBP1, QARS, DARS, KLC2, TRMT2A, PSME1, FGB, KIAA1377, LUC7L2, FBN3, PIK3R2, CRK, GRB2, EGFR, ERBB2, ERBB3, MBIP, LYN, KHDRBS1, IRS4, TRIM54, L3MBTL3, FSD2, EFNB2, SOCS6, TGFBR2, BTN2A1, SKAP1, VSIG4, RELT, HEPACAM2, ABL2, HCK, NCK1, ARL6IP4, PLEKHS1, CCDC14, IQUB, OTUD7B, PARD6A, PCDHB5, PELI3, PELO, PLB1, RBP7, SOCS4, SPSB2, USP2, WBSCR27, ZNF281, ZNF767P, SRC, STAT3, CBL, BTK, CRYBA2, E2F6, MECOM, ANKS1A, FRS3, HSH2D, CLNK, SH2D2A, PPARA, VCP, FER, C17orf53, AUNIP, BRK1, CEP19, CAMK1, CCDC33, CRBN, KLF15, KMT2B, MTF2, OLIG1, PACRGL, WDFY3, DCAF8, WRNIP1, ZMAT1, ZNF451, FOXO1, FYN, PIK3CB, PPP1R12B, PTK2, TERF2, TNNC2, TSPAN2, LNX2, PDGFRB, PTP4A3, PIK3CD, EHD2, HAVCR2, NISCH, PIK3R1, ALDH3B1, TMEM52B, NLGN3, FLRT1MOB3CLATS1, LATS2, APP, SIAH1, TDO2, TFCP2, TNIP1, NT5C2, FAM118A, ZBTB10, CMTM3, KRT40, C10orf107, MAU2, TRIM25


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for PIK3R3_MOB3C


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status
HgenePIK3R3Q92569DB01064IsoprenalinePhosphatidylinositol 3-kinase regulatory subunit gammasmall moleculeapproved|investigational

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RelatedDiseases for PIK3R3_MOB3C


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource