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Fusion gene ID: 27215 |
FusionGeneSummary for PIK3R3_MOB3C |
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Fusion gene information | Fusion gene name: PIK3R3_MOB3C | Fusion gene ID: 27215 | Hgene | Tgene | Gene symbol | PIK3R3 | MOB3C | Gene ID | 8503 | 148932 |
Gene name | phosphoinositide-3-kinase regulatory subunit 3 | MOB kinase activator 3C | |
Synonyms | p55|p55-GAMMA|p55PIK | MOB1E|MOBKL2C | |
Cytomap | 1p34.1 | 1p33 | |
Type of gene | protein-coding | protein-coding | |
Description | phosphatidylinositol 3-kinase regulatory subunit gammaPI3-kinase regulatory subunit gammaPI3-kinase subunit p55-gammaPI3K regulatory subunit gammaphosphatidylinositol 3-kinase 55 kDa regulatory subunit gammaphosphatidylinositol 3-kinase, regulatory s | MOB kinase activator 3CMOB1, Mps One Binder kinase activator-like 2Cmob1 homolog 2C | |
Modification date | 20180523 | 20180519 | |
UniProtAcc | Q92569 | Q70IA8 | |
Ensembl transtripts involved in fusion gene | ENST00000262741, ENST00000372006, ENST00000340332, ENST00000420542, ENST00000354242, ENST00000540385, ENST00000423209, ENST00000488808, | ENST00000319928, ENST00000271139, ENST00000371940, ENST00000477318, | |
Fusion gene scores | * DoF score | 6 X 5 X 6=180 | 3 X 2 X 3=18 |
# samples | 8 | 3 | |
** MAII score | log2(8/180*10)=-1.16992500144231 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | log2(3/18*10)=0.736965594166206 effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs). DoF>8 and MAII>0 | |
Context | PubMed: PIK3R3 [Title/Abstract] AND MOB3C [Title/Abstract] AND fusion [Title/Abstract] | ||
Functional or gene categories assigned by FusionGDB annotation |
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
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Partner | Gene | GO ID | GO term | PubMed ID |
![]() (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
TCGA | LD | CESC | TCGA-VS-A9V0-01A | PIK3R3 | chr1 | 46543187 | - | MOB3C | chr1 | 47079043 | - |
* LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
![]() * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
5CDS-5UTR | ENST00000262741 | ENST00000319928 | PIK3R3 | chr1 | 46543187 | - | MOB3C | chr1 | 47079043 | - |
5CDS-5UTR | ENST00000262741 | ENST00000271139 | PIK3R3 | chr1 | 46543187 | - | MOB3C | chr1 | 47079043 | - |
5CDS-5UTR | ENST00000262741 | ENST00000371940 | PIK3R3 | chr1 | 46543187 | - | MOB3C | chr1 | 47079043 | - |
5CDS-5UTR | ENST00000262741 | ENST00000477318 | PIK3R3 | chr1 | 46543187 | - | MOB3C | chr1 | 47079043 | - |
5CDS-5UTR | ENST00000372006 | ENST00000319928 | PIK3R3 | chr1 | 46543187 | - | MOB3C | chr1 | 47079043 | - |
5CDS-5UTR | ENST00000372006 | ENST00000271139 | PIK3R3 | chr1 | 46543187 | - | MOB3C | chr1 | 47079043 | - |
5CDS-5UTR | ENST00000372006 | ENST00000371940 | PIK3R3 | chr1 | 46543187 | - | MOB3C | chr1 | 47079043 | - |
5CDS-5UTR | ENST00000372006 | ENST00000477318 | PIK3R3 | chr1 | 46543187 | - | MOB3C | chr1 | 47079043 | - |
5CDS-5UTR | ENST00000340332 | ENST00000319928 | PIK3R3 | chr1 | 46543187 | - | MOB3C | chr1 | 47079043 | - |
5CDS-5UTR | ENST00000340332 | ENST00000271139 | PIK3R3 | chr1 | 46543187 | - | MOB3C | chr1 | 47079043 | - |
5CDS-5UTR | ENST00000340332 | ENST00000371940 | PIK3R3 | chr1 | 46543187 | - | MOB3C | chr1 | 47079043 | - |
5CDS-5UTR | ENST00000340332 | ENST00000477318 | PIK3R3 | chr1 | 46543187 | - | MOB3C | chr1 | 47079043 | - |
5CDS-5UTR | ENST00000420542 | ENST00000319928 | PIK3R3 | chr1 | 46543187 | - | MOB3C | chr1 | 47079043 | - |
5CDS-5UTR | ENST00000420542 | ENST00000271139 | PIK3R3 | chr1 | 46543187 | - | MOB3C | chr1 | 47079043 | - |
5CDS-5UTR | ENST00000420542 | ENST00000371940 | PIK3R3 | chr1 | 46543187 | - | MOB3C | chr1 | 47079043 | - |
5CDS-5UTR | ENST00000420542 | ENST00000477318 | PIK3R3 | chr1 | 46543187 | - | MOB3C | chr1 | 47079043 | - |
5CDS-5UTR | ENST00000354242 | ENST00000319928 | PIK3R3 | chr1 | 46543187 | - | MOB3C | chr1 | 47079043 | - |
5CDS-5UTR | ENST00000354242 | ENST00000271139 | PIK3R3 | chr1 | 46543187 | - | MOB3C | chr1 | 47079043 | - |
5CDS-5UTR | ENST00000354242 | ENST00000371940 | PIK3R3 | chr1 | 46543187 | - | MOB3C | chr1 | 47079043 | - |
5CDS-5UTR | ENST00000354242 | ENST00000477318 | PIK3R3 | chr1 | 46543187 | - | MOB3C | chr1 | 47079043 | - |
5CDS-5UTR | ENST00000540385 | ENST00000319928 | PIK3R3 | chr1 | 46543187 | - | MOB3C | chr1 | 47079043 | - |
5CDS-5UTR | ENST00000540385 | ENST00000271139 | PIK3R3 | chr1 | 46543187 | - | MOB3C | chr1 | 47079043 | - |
5CDS-5UTR | ENST00000540385 | ENST00000371940 | PIK3R3 | chr1 | 46543187 | - | MOB3C | chr1 | 47079043 | - |
5CDS-5UTR | ENST00000540385 | ENST00000477318 | PIK3R3 | chr1 | 46543187 | - | MOB3C | chr1 | 47079043 | - |
5CDS-5UTR | ENST00000423209 | ENST00000319928 | PIK3R3 | chr1 | 46543187 | - | MOB3C | chr1 | 47079043 | - |
5CDS-5UTR | ENST00000423209 | ENST00000271139 | PIK3R3 | chr1 | 46543187 | - | MOB3C | chr1 | 47079043 | - |
5CDS-5UTR | ENST00000423209 | ENST00000371940 | PIK3R3 | chr1 | 46543187 | - | MOB3C | chr1 | 47079043 | - |
5CDS-5UTR | ENST00000423209 | ENST00000477318 | PIK3R3 | chr1 | 46543187 | - | MOB3C | chr1 | 47079043 | - |
intron-5UTR | ENST00000488808 | ENST00000319928 | PIK3R3 | chr1 | 46543187 | - | MOB3C | chr1 | 47079043 | - |
intron-5UTR | ENST00000488808 | ENST00000271139 | PIK3R3 | chr1 | 46543187 | - | MOB3C | chr1 | 47079043 | - |
intron-5UTR | ENST00000488808 | ENST00000371940 | PIK3R3 | chr1 | 46543187 | - | MOB3C | chr1 | 47079043 | - |
intron-5UTR | ENST00000488808 | ENST00000477318 | PIK3R3 | chr1 | 46543187 | - | MOB3C | chr1 | 47079043 | - |
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FusionProtFeatures for PIK3R3_MOB3C |
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Hgene | Tgene |
PIK3R3 | MOB3C |
Binds to activated (phosphorylated) protein-tyrosinekinases through its SH2 domain and regulates their kinaseactivity. During insulin stimulation, it also binds to IRS-1. | May regulate the activity of kinases. {ECO:0000250}. |
![]() * Minus value of BPloci means that the break pointn is located before the CDS. |
- In-frame and retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
- In-frame and not-retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
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FusionGeneSequence for PIK3R3_MOB3C |
![]() (nt: nucleotides, aa: amino acids) |
* Fusion amino acid sequences. |
* Fusion transcript sequences (only coding sequence (CDS) region). |
* Fusion transcript sequences (Full-length transcript). |
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FusionGenePPI for PIK3R3_MOB3C |
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Hgene | Hgene's interactors | Tgene | Tgene's interactors |
PIK3R3 | PIK3CA, DRAP1, RB1, IRS2, IRS1, IGF1R, ABCB6, RING1, AMBP, ORM1, SERF1A, GC, KARS, MICAL1, DSN1, VBP1, QARS, DARS, KLC2, TRMT2A, PSME1, FGB, KIAA1377, LUC7L2, FBN3, PIK3R2, CRK, GRB2, EGFR, ERBB2, ERBB3, MBIP, LYN, KHDRBS1, IRS4, TRIM54, L3MBTL3, FSD2, EFNB2, SOCS6, TGFBR2, BTN2A1, SKAP1, VSIG4, RELT, HEPACAM2, ABL2, HCK, NCK1, ARL6IP4, PLEKHS1, CCDC14, IQUB, OTUD7B, PARD6A, PCDHB5, PELI3, PELO, PLB1, RBP7, SOCS4, SPSB2, USP2, WBSCR27, ZNF281, ZNF767P, SRC, STAT3, CBL, BTK, CRYBA2, E2F6, MECOM, ANKS1A, FRS3, HSH2D, CLNK, SH2D2A, PPARA, VCP, FER, C17orf53, AUNIP, BRK1, CEP19, CAMK1, CCDC33, CRBN, KLF15, KMT2B, MTF2, OLIG1, PACRGL, WDFY3, DCAF8, WRNIP1, ZMAT1, ZNF451, FOXO1, FYN, PIK3CB, PPP1R12B, PTK2, TERF2, TNNC2, TSPAN2, LNX2, PDGFRB, PTP4A3, PIK3CD, EHD2, HAVCR2, NISCH, PIK3R1, ALDH3B1, TMEM52B, NLGN3, FLRT1 | MOB3C | LATS1, LATS2, APP, SIAH1, TDO2, TFCP2, TNIP1, NT5C2, FAM118A, ZBTB10, CMTM3, KRT40, C10orf107, MAU2, TRIM25 |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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RelatedDrugs for PIK3R3_MOB3C |
![]() (DrugBank Version 5.1.0 2018-04-02) |
Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
Hgene | PIK3R3 | Q92569 | DB01064 | Isoprenaline | Phosphatidylinositol 3-kinase regulatory subunit gamma | small molecule | approved|investigational |
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RelatedDiseases for PIK3R3_MOB3C |
![]() (DisGeNet 4.0) |
Partner | Gene | Disease ID | Disease name | # pubmeds | Source |