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Fusion gene ID: 27214 |
FusionGeneSummary for PIK3R3_LRRC41 |
 Fusion gene summary |
| Fusion gene information | Fusion gene name: PIK3R3_LRRC41 | Fusion gene ID: 27214 | Hgene | Tgene | Gene symbol | PIK3R3 | LRRC41 | Gene ID | 8503 | 10489 |
| Gene name | phosphoinositide-3-kinase regulatory subunit 3 | leucine rich repeat containing 41 | |
| Synonyms | p55|p55-GAMMA|p55PIK | MUF1|PP7759 | |
| Cytomap | 1p34.1 | 1p34.1-p33 | |
| Type of gene | protein-coding | protein-coding | |
| Description | phosphatidylinositol 3-kinase regulatory subunit gammaPI3-kinase regulatory subunit gammaPI3-kinase subunit p55-gammaPI3K regulatory subunit gammaphosphatidylinositol 3-kinase 55 kDa regulatory subunit gammaphosphatidylinositol 3-kinase, regulatory s | leucine-rich repeat-containing protein 41MUF1 protein (MUF1)elongin BC-interacting leucine-rich repeat proteinprotein Muf1 | |
| Modification date | 20180523 | 20180523 | |
| UniProtAcc | Q92569 | Q15345 | |
| Ensembl transtripts involved in fusion gene | ENST00000262741, ENST00000372006, ENST00000340332, ENST00000420542, ENST00000354242, ENST00000540385, ENST00000423209, ENST00000488808, | ENST00000343304, ENST00000472710, | |
| Fusion gene scores | * DoF score | 6 X 5 X 6=180 | 5 X 6 X 5=150 |
| # samples | 8 | 7 | |
| ** MAII score | log2(8/180*10)=-1.16992500144231 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | log2(7/150*10)=-1.09953567355091 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | |
| Context | PubMed: PIK3R3 [Title/Abstract] AND LRRC41 [Title/Abstract] AND fusion [Title/Abstract] | ||
| Functional or gene categories assigned by FusionGDB annotation | |||
| * DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
| Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Partner | Gene | GO ID | GO term | PubMed ID |
| Fusion gene information from three resources (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| TCGA | LD | BRCA | TCGA-C8-A135-01A | PIK3R3 | chr1 | 46546314 | - | LRRC41 | chr1 | 46733349 | - |
| TCGA | LD | BRCA | TCGA-OL-A5D7-01A | PIK3R3 | chr1 | 46527601 | - | LRRC41 | chr1 | 46747057 | - |
| TCGA | RV | UCS | TCGA-N9-A4Q8-01A | PIK3R3 | chr1 | 46543187 | - | LRRC41 | chr1 | 46752171 | - |
| * LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
| Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| 5CDS-intron | ENST00000262741 | ENST00000343304 | PIK3R3 | chr1 | 46546314 | - | LRRC41 | chr1 | 46733349 | - |
| 5CDS-intron | ENST00000262741 | ENST00000472710 | PIK3R3 | chr1 | 46546314 | - | LRRC41 | chr1 | 46733349 | - |
| 5CDS-intron | ENST00000372006 | ENST00000343304 | PIK3R3 | chr1 | 46546314 | - | LRRC41 | chr1 | 46733349 | - |
| 5CDS-intron | ENST00000372006 | ENST00000472710 | PIK3R3 | chr1 | 46546314 | - | LRRC41 | chr1 | 46733349 | - |
| intron-intron | ENST00000340332 | ENST00000343304 | PIK3R3 | chr1 | 46546314 | - | LRRC41 | chr1 | 46733349 | - |
| intron-intron | ENST00000340332 | ENST00000472710 | PIK3R3 | chr1 | 46546314 | - | LRRC41 | chr1 | 46733349 | - |
| 5CDS-intron | ENST00000420542 | ENST00000343304 | PIK3R3 | chr1 | 46546314 | - | LRRC41 | chr1 | 46733349 | - |
| 5CDS-intron | ENST00000420542 | ENST00000472710 | PIK3R3 | chr1 | 46546314 | - | LRRC41 | chr1 | 46733349 | - |
| 5CDS-intron | ENST00000354242 | ENST00000343304 | PIK3R3 | chr1 | 46546314 | - | LRRC41 | chr1 | 46733349 | - |
| 5CDS-intron | ENST00000354242 | ENST00000472710 | PIK3R3 | chr1 | 46546314 | - | LRRC41 | chr1 | 46733349 | - |
| 5CDS-intron | ENST00000540385 | ENST00000343304 | PIK3R3 | chr1 | 46546314 | - | LRRC41 | chr1 | 46733349 | - |
| 5CDS-intron | ENST00000540385 | ENST00000472710 | PIK3R3 | chr1 | 46546314 | - | LRRC41 | chr1 | 46733349 | - |
| 5CDS-intron | ENST00000423209 | ENST00000343304 | PIK3R3 | chr1 | 46546314 | - | LRRC41 | chr1 | 46733349 | - |
| 5CDS-intron | ENST00000423209 | ENST00000472710 | PIK3R3 | chr1 | 46546314 | - | LRRC41 | chr1 | 46733349 | - |
| intron-intron | ENST00000488808 | ENST00000343304 | PIK3R3 | chr1 | 46546314 | - | LRRC41 | chr1 | 46733349 | - |
| intron-intron | ENST00000488808 | ENST00000472710 | PIK3R3 | chr1 | 46546314 | - | LRRC41 | chr1 | 46733349 | - |
| Frame-shift | ENST00000262741 | ENST00000343304 | PIK3R3 | chr1 | 46527601 | - | LRRC41 | chr1 | 46747057 | - |
| 5CDS-5UTR | ENST00000262741 | ENST00000472710 | PIK3R3 | chr1 | 46527601 | - | LRRC41 | chr1 | 46747057 | - |
| In-frame | ENST00000372006 | ENST00000343304 | PIK3R3 | chr1 | 46527601 | - | LRRC41 | chr1 | 46747057 | - |
| 5CDS-5UTR | ENST00000372006 | ENST00000472710 | PIK3R3 | chr1 | 46527601 | - | LRRC41 | chr1 | 46747057 | - |
| Frame-shift | ENST00000340332 | ENST00000343304 | PIK3R3 | chr1 | 46527601 | - | LRRC41 | chr1 | 46747057 | - |
| 5CDS-5UTR | ENST00000340332 | ENST00000472710 | PIK3R3 | chr1 | 46527601 | - | LRRC41 | chr1 | 46747057 | - |
| Frame-shift | ENST00000420542 | ENST00000343304 | PIK3R3 | chr1 | 46527601 | - | LRRC41 | chr1 | 46747057 | - |
| 5CDS-5UTR | ENST00000420542 | ENST00000472710 | PIK3R3 | chr1 | 46527601 | - | LRRC41 | chr1 | 46747057 | - |
| Frame-shift | ENST00000354242 | ENST00000343304 | PIK3R3 | chr1 | 46527601 | - | LRRC41 | chr1 | 46747057 | - |
| 5CDS-5UTR | ENST00000354242 | ENST00000472710 | PIK3R3 | chr1 | 46527601 | - | LRRC41 | chr1 | 46747057 | - |
| Frame-shift | ENST00000540385 | ENST00000343304 | PIK3R3 | chr1 | 46527601 | - | LRRC41 | chr1 | 46747057 | - |
| 5CDS-5UTR | ENST00000540385 | ENST00000472710 | PIK3R3 | chr1 | 46527601 | - | LRRC41 | chr1 | 46747057 | - |
| Frame-shift | ENST00000423209 | ENST00000343304 | PIK3R3 | chr1 | 46527601 | - | LRRC41 | chr1 | 46747057 | - |
| 5CDS-5UTR | ENST00000423209 | ENST00000472710 | PIK3R3 | chr1 | 46527601 | - | LRRC41 | chr1 | 46747057 | - |
| intron-3CDS | ENST00000488808 | ENST00000343304 | PIK3R3 | chr1 | 46527601 | - | LRRC41 | chr1 | 46747057 | - |
| intron-5UTR | ENST00000488808 | ENST00000472710 | PIK3R3 | chr1 | 46527601 | - | LRRC41 | chr1 | 46747057 | - |
| Frame-shift | ENST00000262741 | ENST00000343304 | PIK3R3 | chr1 | 46543187 | - | LRRC41 | chr1 | 46752171 | - |
| 5CDS-5UTR | ENST00000262741 | ENST00000472710 | PIK3R3 | chr1 | 46543187 | - | LRRC41 | chr1 | 46752171 | - |
| Frame-shift | ENST00000372006 | ENST00000343304 | PIK3R3 | chr1 | 46543187 | - | LRRC41 | chr1 | 46752171 | - |
| 5CDS-5UTR | ENST00000372006 | ENST00000472710 | PIK3R3 | chr1 | 46543187 | - | LRRC41 | chr1 | 46752171 | - |
| In-frame | ENST00000340332 | ENST00000343304 | PIK3R3 | chr1 | 46543187 | - | LRRC41 | chr1 | 46752171 | - |
| 5CDS-5UTR | ENST00000340332 | ENST00000472710 | PIK3R3 | chr1 | 46543187 | - | LRRC41 | chr1 | 46752171 | - |
| In-frame | ENST00000420542 | ENST00000343304 | PIK3R3 | chr1 | 46543187 | - | LRRC41 | chr1 | 46752171 | - |
| 5CDS-5UTR | ENST00000420542 | ENST00000472710 | PIK3R3 | chr1 | 46543187 | - | LRRC41 | chr1 | 46752171 | - |
| In-frame | ENST00000354242 | ENST00000343304 | PIK3R3 | chr1 | 46543187 | - | LRRC41 | chr1 | 46752171 | - |
| 5CDS-5UTR | ENST00000354242 | ENST00000472710 | PIK3R3 | chr1 | 46543187 | - | LRRC41 | chr1 | 46752171 | - |
| Frame-shift | ENST00000540385 | ENST00000343304 | PIK3R3 | chr1 | 46543187 | - | LRRC41 | chr1 | 46752171 | - |
| 5CDS-5UTR | ENST00000540385 | ENST00000472710 | PIK3R3 | chr1 | 46543187 | - | LRRC41 | chr1 | 46752171 | - |
| Frame-shift | ENST00000423209 | ENST00000343304 | PIK3R3 | chr1 | 46543187 | - | LRRC41 | chr1 | 46752171 | - |
| 5CDS-5UTR | ENST00000423209 | ENST00000472710 | PIK3R3 | chr1 | 46543187 | - | LRRC41 | chr1 | 46752171 | - |
| intron-3CDS | ENST00000488808 | ENST00000343304 | PIK3R3 | chr1 | 46543187 | - | LRRC41 | chr1 | 46752171 | - |
| intron-5UTR | ENST00000488808 | ENST00000472710 | PIK3R3 | chr1 | 46543187 | - | LRRC41 | chr1 | 46752171 | - |
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FusionProtFeatures for PIK3R3_LRRC41 |
| Main function of each fusion partner protein. (from UniProt) |
| Hgene | Tgene |
| PIK3R3 | LRRC41 |
| Binds to activated (phosphorylated) protein-tyrosinekinases through its SH2 domain and regulates their kinaseactivity. During insulin stimulation, it also binds to IRS-1. | Probable substrate recognition component of an ECS(Elongin BC-CUL2/5-SOCS-box protein) E3 ubiquitin ligase complexwhich mediates the ubiquitination and subsequent proteasomaldegradation of target proteins. {ECO:0000269|PubMed:15601820}. |
| Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at . * Minus value of BPloci means that the break pointn is located before the CDS. |
| - In-frame and retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
| - In-frame and not-retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
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FusionGeneSequence for PIK3R3_LRRC41 |
| For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. (nt: nucleotides, aa: amino acids) |
| * Fusion amino acid sequences. |
| >In-frame_PIK3R3_ENST00000340332_chr1_46543187_-_LRRC41_ENST00000343304_chr1_46752171_-_762aa MYNTVWSMDRDDADWREVMMPYSTELIFYIEMDPPAAEVNDKLRDMPDGTFLVRDASTKMQGDYTLTLRVXHVGEPSLWRPFFPMFYVGP LMCLLTGVFVISGSHLFCTAPAMSDSSPSVTCCRVQPSWWLSPTAGFWRPWPAPCTLSSSATCCSLMWLLSSHFGSCCISSFTMGLSVKC RYTPGLCLSQPFSSLFSPXVLASGNQGLVAHPAASVERPPEAGPHPEMKGPSYWAHVGPAGMLLSDVLQPXWPAGVRVKPSRCPELHLPL GXHAGAHRRAXQQAEQTLRGSCTPQPPPMRLLAPSGHLLLQQPPPLPLLLHPHTNGHQLAQPHSLSPXSVSSELQGRRVLAPVRGLVQSL KTCMTSFLLWLARRRMAKRWRLGKWLVELWMDQIPAAWGFQHWKLHKDSAASPPWSYSQFHSPQRQPXHYATCXAPGCHWRASHSPTMAW ALTSSACXTACGPCQARLDVASVPCISVTCSHHCPSWSXHVLSCEHCPCYGSSLFVLTTQASGTTLVCQGMQGPLATXXAMRRYQKTAWS SWRWDFHGEPSQPHCCAPFXRPRVLCSSCPWIVPPLPLPRILGLFCKHSKSTTXPXKDXASMTXISLTVRARCSFCYRIXLCKRLPSPSA VCLRSAQPNFCLRWLLLXRATPHXRASGCQGTAWGMLACWPWQMFSQRIHPPLSVSWTSVPTASSQMGFWSSPSGWSAGAVEPLVTCASS >In-frame_PIK3R3_ENST00000420542_chr1_46543187_-_LRRC41_ENST00000343304_chr1_46752171_-_798aa MYNTVWSMDRDDADWREVMMPYSTELIFYIEMDPPALPPKPPKPMTSAVPNGMKDSSVSLQDAEWYWGDISREEVNDKLRDMPDGTFLVR DASTKMQGDYTLTLRVXHVGEPSLWRPFFPMFYVGPLMCLLTGVFVISGSHLFCTAPAMSDSSPSVTCCRVQPSWWLSPTAGFWRPWPAP CTLSSSATCCSLMWLLSSHFGSCCISSFTMGLSVKCRYTPGLCLSQPFSSLFSPXVLASGNQGLVAHPAASVERPPEAGPHPEMKGPSYW AHVGPAGMLLSDVLQPXWPAGVRVKPSRCPELHLPLGXHAGAHRRAXQQAEQTLRGSCTPQPPPMRLLAPSGHLLLQQPPPLPLLLHPHT NGHQLAQPHSLSPXSVSSELQGRRVLAPVRGLVQSLKTCMTSFLLWLARRRMAKRWRLGKWLVELWMDQIPAAWGFQHWKLHKDSAASPP WSYSQFHSPQRQPXHYATCXAPGCHWRASHSPTMAWALTSSACXTACGPCQARLDVASVPCISVTCSHHCPSWSXHVLSCEHCPCYGSSL FVLTTQASGTTLVCQGMQGPLATXXAMRRYQKTAWSSWRWDFHGEPSQPHCCAPFXRPRVLCSSCPWIVPPLPLPRILGLFCKHSKSTTX PXKDXASMTXISLTVRARCSFCYRIXLCKRLPSPSAVCLRSAQPNFCLRWLLLXRATPHXRASGCQGTAWGMLACWPWQMFSQRIHPPLS >In-frame_PIK3R3_ENST00000354242_chr1_46543187_-_LRRC41_ENST00000343304_chr1_46752171_-_798aa MYNTVWSMDRDDADWREVMMPYSTELIFYIEMDPPALPPKPPKPMTSAVPNGMKDSSVSLQDAEWYWGDISREEVNDKLRDMPDGTFLVR DASTKMQGDYTLTLRVXHVGEPSLWRPFFPMFYVGPLMCLLTGVFVISGSHLFCTAPAMSDSSPSVTCCRVQPSWWLSPTAGFWRPWPAP CTLSSSATCCSLMWLLSSHFGSCCISSFTMGLSVKCRYTPGLCLSQPFSSLFSPXVLASGNQGLVAHPAASVERPPEAGPHPEMKGPSYW AHVGPAGMLLSDVLQPXWPAGVRVKPSRCPELHLPLGXHAGAHRRAXQQAEQTLRGSCTPQPPPMRLLAPSGHLLLQQPPPLPLLLHPHT NGHQLAQPHSLSPXSVSSELQGRRVLAPVRGLVQSLKTCMTSFLLWLARRRMAKRWRLGKWLVELWMDQIPAAWGFQHWKLHKDSAASPP WSYSQFHSPQRQPXHYATCXAPGCHWRASHSPTMAWALTSSACXTACGPCQARLDVASVPCISVTCSHHCPSWSXHVLSCEHCPCYGSSL FVLTTQASGTTLVCQGMQGPLATXXAMRRYQKTAWSSWRWDFHGEPSQPHCCAPFXRPRVLCSSCPWIVPPLPLPRILGLFCKHSKSTTX PXKDXASMTXISLTVRARCSFCYRIXLCKRLPSPSAVCLRSAQPNFCLRWLLLXRATPHXRASGCQGTAWGMLACWPWQMFSQRIHPPLS >In-frame_PIK3R3_ENST00000372006_chr1_46527601_-_LRRC41_ENST00000343304_chr1_46747057_-_569aa MYNTVWSMDRDDADWREVMMPYSTELIFYIEMDPPALPPKPPKPMTSAVPNGMKDSSVSLQDAEWYWGDISREEVNDKLRDMPDGTFLVR DASTKMQGDYTLTLRKGGNNKLIKIYHRDGKYGFSDPLTFNSVVELINHYHHESLAQYNPKLDVKLMYPVSRYQQDQLVKEDNIDAVGKK LQEYHSQYQEKSKEYDRLYEEYTRTSQEIQMKRTAIEAFNETIKIFEEQCHTQEQHSKEYIERFRREGNEKEIERPGLXHLPPARQPAGP VRPGWMSPPCPASQXPVLTTAHPGADTCYRASTAPATGPLYSCXPPKPAGQPWCARECRAPXPHNRRXGDTRKLPGAVGDGISTGSPASP TAVLRSEGLGFSAAAVPGXCHLCLSPGFWACFANTQRVQPSPEKTELPXHESRXLSERGALFATESDSARDYLLLLPSVXEAPSPISAXD GCCYEGQLHTEGPPAAREPPGECWPAGLGRCFLRGFILLSLSAGHQFQLHQARWASGVRQAAGALGPWSLWSPAPLPKLAGPGCSHSQGS |
| * Fusion transcript sequences (only coding sequence (CDS) region). |
| >In-frame_PIK3R3_ENST00000340332_chr1_46543187_-_LRRC41_ENST00000343304_chr1_46752171_-_2288nt ATGTACAATACGGTGTGGAGTATGGACCGCGATGACGCAGACTGGAGGGAGGTGATGATGCCCTATTCGACAGAACTGATATTTTATATT GAAATGGATCCTCCAGCTGCGGAGGTAAATGACAAATTGCGGGATATGCCAGATGGGACCTTCTTGGTCCGAGATGCCTCAACAAAAATG CAGGGAGATTATACTTTGACTTTGCGAGTGTGACATGTTGGCGAGCCAAGTTTATGGAGGCCTTTTTTTCCCATGTTCTACGTGGGACCA TTGATGTGTCTTCTGACAGGCGTCTTTGTGATCAGCGGTTCTCACCTCTTCTGCACAGCTCCCGCCATGTCCGACAGCTCACCATCTGTA ACATGCTGCAGGGTGCAACCGAGCTGGTGGCTGAGCCCAACCGCAGGGTTCTGGAGACCCTGGCCAGCTCCCTGCACACTCTCAAGTTCC GCCACCTGCTGTTCTCTGATGTGGCTGCTCAGCAGTCACTTCGGCAGCTGTTGCATCAGCTCATTCACCATGGGGCTGTCAGTCAAGTGT CGCTATACTCCTGGCCTGTGCCTGAGTCAGCCCTTTTCATCCTTATTCTCACCATGAGTGCTGGCTTCTGGCAACCAGGGCCTGGTGGCC CACCCTGCCGCCTCTGTGGAGAGGCCTCCCGAGGCCGGGCCCCATCCCGAGATGAAGGGTCCCTCTTATTGGGCTCACGTCGGCCCCGCC GGGATGCTGCTGAGCGATGTGCTGCAGCCCTGATGGCCAGCCGGCGTAAGAGTGAAGCCAAGCAGATGCCCAGAGCTGCACCTGCCACTC GGGTAACACGCCGGAGCACACAGGAGAGCCTGACAGCAGGCGGAACAGACCTTAAGAGGGAGCTGCACCCCCCAGCCACCTCCCATGAGG CTCCTGGCACCAAGCGGTCACCTTCTGCTCCAGCAGCCACCTCCTCTGCCTCTTCTTCTACATCCTCATACAAACGGGCACCAGCTAGCT CAGCCCCACAGCCTAAGCCCCTAAAGCGTTTCAAGCGAGCTGCAGGGAAGAAGGGTGCTCGCACCCGTCAGGGGCCTGGTGCAGAGTCTG AAGACCTGTATGACTTCGTTTTTATTGTGGCTGGCGAGAAGGAGGATGGCGAAGAGATGGAGATTGGGGAAGTGGCTTGTGGAGCTTTGG ATGGATCAGATCCCAGCTGCCTGGGGCTTCCAGCACTGGAAGCTTCACAAAGATTCCGCAGCATCTCCACCTTGGAGCTATTCACAGTTC CACTCTCCACAGAGGCAGCCCTGACACTATGCCACCTGCTGAGCTCCTGGGTGTCACTGGAGAGCCTCACACTCTCCTACAATGGCCTGG GCTCTAACATCTTCCGCCTGCTAGACAGCCTGCGGGCCCTGTCAGGCCAGGCTGGATGTCGCCTCCGTGCCCTGCATCTCAGTGACCTGT TCTCACCACTGCCCATCCTGGAGCTGACACGTGCTATCGTGCGAGCACTGCCCCTGCTACGGGTCCTCTCTATTCGTGTTGACCACCCAA GCCAGCGGGACAACCCTGGTGTGCCAGGGAATGCAGGGCCCCCTAGCCACATAATAGGCGATGAGGAGATACCAGAAAACTGCCTGGAGC AGTTGGAGATGGGATTTCCACGGGGAGCCCAGCCAGCCCCACTGCTGTGCTCCGTTCTGAAGGCCTCGGGTTCTCTGCAGCAGCTGTCCC TGGATAGTGCCACCTTTGCCTCTCCCCAGGATTTTGGGCTTGTTTTGCAAACACTCAAAGAGTACAACCTAGCCCTGAAAAGACTGAGCT TCCATGACATGAATCTCGCTGACTGTCAGAGCGAGGTGCTCTTTTTGCTACAGAATCTGACTCTGCAAGAGATTACCTTCTCCTTCTGCC GTCTGTTTGAGAAGCGCCCAGCCCAATTTCTGCCTGAGATGGTTGCTGCTATGAAGGGCAACTCCACACTGAAGGGCCTCCGGCTGCCAG GGAACCGCCTGGGGAATGCTGGCCTGCTGGCCTTGGCAGATGTTTTCTCAGAGGATTCATCCTCCTCTCTCTGTCAGCTGGACATCAGTT CCAACTGCATCAAGCCAGATGGGCTTCTGGAGTTCGCCAAGCGGCTGGAGCGCTGGGGCCGTGGAGCCTTTGGTCACCTGCGCCTCTTCC AAAACTGGCTGGACCAGGATGCAGTCACAGCCAGGGAAGCCATCCGGCGGCTCCGGGCTACCTGCCATGTGGTTAGCGACTCATGGGACT >In-frame_PIK3R3_ENST00000420542_chr1_46543187_-_LRRC41_ENST00000343304_chr1_46752171_-_2396nt ATGTACAATACGGTGTGGAGTATGGACCGCGATGACGCAGACTGGAGGGAGGTGATGATGCCCTATTCGACAGAACTGATATTTTATATT GAAATGGATCCTCCAGCTCTTCCACCAAAGCCACCTAAGCCAATGACTTCAGCAGTTCCAAATGGAATGAAGGACAGTTCTGTTTCTCTT CAGGATGCAGAATGGTACTGGGGGGATATTTCAAGGGAGGAGGTAAATGACAAATTGCGGGATATGCCAGATGGGACCTTCTTGGTCCGA GATGCCTCAACAAAAATGCAGGGAGATTATACTTTGACTTTGCGAGTGTGACATGTTGGCGAGCCAAGTTTATGGAGGCCTTTTTTTCCC ATGTTCTACGTGGGACCATTGATGTGTCTTCTGACAGGCGTCTTTGTGATCAGCGGTTCTCACCTCTTCTGCACAGCTCCCGCCATGTCC GACAGCTCACCATCTGTAACATGCTGCAGGGTGCAACCGAGCTGGTGGCTGAGCCCAACCGCAGGGTTCTGGAGACCCTGGCCAGCTCCC TGCACACTCTCAAGTTCCGCCACCTGCTGTTCTCTGATGTGGCTGCTCAGCAGTCACTTCGGCAGCTGTTGCATCAGCTCATTCACCATG GGGCTGTCAGTCAAGTGTCGCTATACTCCTGGCCTGTGCCTGAGTCAGCCCTTTTCATCCTTATTCTCACCATGAGTGCTGGCTTCTGGC AACCAGGGCCTGGTGGCCCACCCTGCCGCCTCTGTGGAGAGGCCTCCCGAGGCCGGGCCCCATCCCGAGATGAAGGGTCCCTCTTATTGG GCTCACGTCGGCCCCGCCGGGATGCTGCTGAGCGATGTGCTGCAGCCCTGATGGCCAGCCGGCGTAAGAGTGAAGCCAAGCAGATGCCCA GAGCTGCACCTGCCACTCGGGTAACACGCCGGAGCACACAGGAGAGCCTGACAGCAGGCGGAACAGACCTTAAGAGGGAGCTGCACCCCC CAGCCACCTCCCATGAGGCTCCTGGCACCAAGCGGTCACCTTCTGCTCCAGCAGCCACCTCCTCTGCCTCTTCTTCTACATCCTCATACA AACGGGCACCAGCTAGCTCAGCCCCACAGCCTAAGCCCCTAAAGCGTTTCAAGCGAGCTGCAGGGAAGAAGGGTGCTCGCACCCGTCAGG GGCCTGGTGCAGAGTCTGAAGACCTGTATGACTTCGTTTTTATTGTGGCTGGCGAGAAGGAGGATGGCGAAGAGATGGAGATTGGGGAAG TGGCTTGTGGAGCTTTGGATGGATCAGATCCCAGCTGCCTGGGGCTTCCAGCACTGGAAGCTTCACAAAGATTCCGCAGCATCTCCACCT TGGAGCTATTCACAGTTCCACTCTCCACAGAGGCAGCCCTGACACTATGCCACCTGCTGAGCTCCTGGGTGTCACTGGAGAGCCTCACAC TCTCCTACAATGGCCTGGGCTCTAACATCTTCCGCCTGCTAGACAGCCTGCGGGCCCTGTCAGGCCAGGCTGGATGTCGCCTCCGTGCCC TGCATCTCAGTGACCTGTTCTCACCACTGCCCATCCTGGAGCTGACACGTGCTATCGTGCGAGCACTGCCCCTGCTACGGGTCCTCTCTA TTCGTGTTGACCACCCAAGCCAGCGGGACAACCCTGGTGTGCCAGGGAATGCAGGGCCCCCTAGCCACATAATAGGCGATGAGGAGATAC CAGAAAACTGCCTGGAGCAGTTGGAGATGGGATTTCCACGGGGAGCCCAGCCAGCCCCACTGCTGTGCTCCGTTCTGAAGGCCTCGGGTT CTCTGCAGCAGCTGTCCCTGGATAGTGCCACCTTTGCCTCTCCCCAGGATTTTGGGCTTGTTTTGCAAACACTCAAAGAGTACAACCTAG CCCTGAAAAGACTGAGCTTCCATGACATGAATCTCGCTGACTGTCAGAGCGAGGTGCTCTTTTTGCTACAGAATCTGACTCTGCAAGAGA TTACCTTCTCCTTCTGCCGTCTGTTTGAGAAGCGCCCAGCCCAATTTCTGCCTGAGATGGTTGCTGCTATGAAGGGCAACTCCACACTGA AGGGCCTCCGGCTGCCAGGGAACCGCCTGGGGAATGCTGGCCTGCTGGCCTTGGCAGATGTTTTCTCAGAGGATTCATCCTCCTCTCTCT GTCAGCTGGACATCAGTTCCAACTGCATCAAGCCAGATGGGCTTCTGGAGTTCGCCAAGCGGCTGGAGCGCTGGGGCCGTGGAGCCTTTG GTCACCTGCGCCTCTTCCAAAACTGGCTGGACCAGGATGCAGTCACAGCCAGGGAAGCCATCCGGCGGCTCCGGGCTACCTGCCATGTGG >In-frame_PIK3R3_ENST00000354242_chr1_46543187_-_LRRC41_ENST00000343304_chr1_46752171_-_2396nt ATGTACAATACGGTGTGGAGTATGGACCGCGATGACGCAGACTGGAGGGAGGTGATGATGCCCTATTCGACAGAACTGATATTTTATATT GAAATGGATCCTCCAGCTCTTCCACCAAAGCCACCTAAGCCAATGACTTCAGCAGTTCCAAATGGAATGAAGGACAGTTCTGTTTCTCTT CAGGATGCAGAATGGTACTGGGGGGATATTTCAAGGGAGGAGGTAAATGACAAATTGCGGGATATGCCAGATGGGACCTTCTTGGTCCGA GATGCCTCAACAAAAATGCAGGGAGATTATACTTTGACTTTGCGAGTGTGACATGTTGGCGAGCCAAGTTTATGGAGGCCTTTTTTTCCC ATGTTCTACGTGGGACCATTGATGTGTCTTCTGACAGGCGTCTTTGTGATCAGCGGTTCTCACCTCTTCTGCACAGCTCCCGCCATGTCC GACAGCTCACCATCTGTAACATGCTGCAGGGTGCAACCGAGCTGGTGGCTGAGCCCAACCGCAGGGTTCTGGAGACCCTGGCCAGCTCCC TGCACACTCTCAAGTTCCGCCACCTGCTGTTCTCTGATGTGGCTGCTCAGCAGTCACTTCGGCAGCTGTTGCATCAGCTCATTCACCATG GGGCTGTCAGTCAAGTGTCGCTATACTCCTGGCCTGTGCCTGAGTCAGCCCTTTTCATCCTTATTCTCACCATGAGTGCTGGCTTCTGGC AACCAGGGCCTGGTGGCCCACCCTGCCGCCTCTGTGGAGAGGCCTCCCGAGGCCGGGCCCCATCCCGAGATGAAGGGTCCCTCTTATTGG GCTCACGTCGGCCCCGCCGGGATGCTGCTGAGCGATGTGCTGCAGCCCTGATGGCCAGCCGGCGTAAGAGTGAAGCCAAGCAGATGCCCA GAGCTGCACCTGCCACTCGGGTAACACGCCGGAGCACACAGGAGAGCCTGACAGCAGGCGGAACAGACCTTAAGAGGGAGCTGCACCCCC CAGCCACCTCCCATGAGGCTCCTGGCACCAAGCGGTCACCTTCTGCTCCAGCAGCCACCTCCTCTGCCTCTTCTTCTACATCCTCATACA AACGGGCACCAGCTAGCTCAGCCCCACAGCCTAAGCCCCTAAAGCGTTTCAAGCGAGCTGCAGGGAAGAAGGGTGCTCGCACCCGTCAGG GGCCTGGTGCAGAGTCTGAAGACCTGTATGACTTCGTTTTTATTGTGGCTGGCGAGAAGGAGGATGGCGAAGAGATGGAGATTGGGGAAG TGGCTTGTGGAGCTTTGGATGGATCAGATCCCAGCTGCCTGGGGCTTCCAGCACTGGAAGCTTCACAAAGATTCCGCAGCATCTCCACCT TGGAGCTATTCACAGTTCCACTCTCCACAGAGGCAGCCCTGACACTATGCCACCTGCTGAGCTCCTGGGTGTCACTGGAGAGCCTCACAC TCTCCTACAATGGCCTGGGCTCTAACATCTTCCGCCTGCTAGACAGCCTGCGGGCCCTGTCAGGCCAGGCTGGATGTCGCCTCCGTGCCC TGCATCTCAGTGACCTGTTCTCACCACTGCCCATCCTGGAGCTGACACGTGCTATCGTGCGAGCACTGCCCCTGCTACGGGTCCTCTCTA TTCGTGTTGACCACCCAAGCCAGCGGGACAACCCTGGTGTGCCAGGGAATGCAGGGCCCCCTAGCCACATAATAGGCGATGAGGAGATAC CAGAAAACTGCCTGGAGCAGTTGGAGATGGGATTTCCACGGGGAGCCCAGCCAGCCCCACTGCTGTGCTCCGTTCTGAAGGCCTCGGGTT CTCTGCAGCAGCTGTCCCTGGATAGTGCCACCTTTGCCTCTCCCCAGGATTTTGGGCTTGTTTTGCAAACACTCAAAGAGTACAACCTAG CCCTGAAAAGACTGAGCTTCCATGACATGAATCTCGCTGACTGTCAGAGCGAGGTGCTCTTTTTGCTACAGAATCTGACTCTGCAAGAGA TTACCTTCTCCTTCTGCCGTCTGTTTGAGAAGCGCCCAGCCCAATTTCTGCCTGAGATGGTTGCTGCTATGAAGGGCAACTCCACACTGA AGGGCCTCCGGCTGCCAGGGAACCGCCTGGGGAATGCTGGCCTGCTGGCCTTGGCAGATGTTTTCTCAGAGGATTCATCCTCCTCTCTCT GTCAGCTGGACATCAGTTCCAACTGCATCAAGCCAGATGGGCTTCTGGAGTTCGCCAAGCGGCTGGAGCGCTGGGGCCGTGGAGCCTTTG GTCACCTGCGCCTCTTCCAAAACTGGCTGGACCAGGATGCAGTCACAGCCAGGGAAGCCATCCGGCGGCTCCGGGCTACCTGCCATGTGG >In-frame_PIK3R3_ENST00000372006_chr1_46527601_-_LRRC41_ENST00000343304_chr1_46747057_-_1708nt ATGTACAATACGGTGTGGAGTATGGACCGCGATGACGCAGACTGGAGGGAGGTGATGATGCCCTATTCGACAGAACTGATATTTTATATT GAAATGGATCCTCCAGCTCTTCCACCAAAGCCACCTAAGCCAATGACTTCAGCAGTTCCAAATGGAATGAAGGACAGTTCTGTTTCTCTT CAGGATGCAGAATGGTACTGGGGGGATATTTCAAGGGAGGAGGTAAATGACAAATTGCGGGATATGCCAGATGGGACCTTCTTGGTCCGA GATGCCTCAACAAAAATGCAGGGAGATTATACTTTGACTTTGCGGAAGGGAGGCAATAATAAGTTAATAAAGATCTATCACCGGGATGGT AAATATGGCTTTTCTGATCCTCTGACATTTAATTCCGTGGTGGAGCTCATTAACCACTATCACCATGAATCTCTTGCTCAGTACAATCCC AAACTTGATGTGAAGCTGATGTACCCAGTGTCCAGATACCAACAGGATCAGTTGGTAAAAGAAGATAATATTGATGCAGTAGGTAAAAAA CTGCAAGAATACCACTCTCAGTATCAGGAGAAGAGTAAAGAGTATGATAGGCTGTATGAAGAATATACTAGAACATCCCAGGAAATACAG ATGAAGAGGACTGCAATAGAAGCTTTTAATGAAACAATTAAAATATTTGAAGAGCAGTGTCACACACAAGAACAACATAGCAAAGAATAT ATTGAGCGATTTCGCAGAGAGGGGAATGAAAAGGAGATTGAACGGCCTGGGCTCTAACATCTTCCGCCTGCTAGACAGCCTGCGGGCCCT GTCAGGCCAGGCTGGATGTCGCCTCCGTGCCCTGCATCTCAGTGACCTGTTCTCACCACTGCCCATCCTGGAGCTGACACGTGCTATCGT GCGAGCACTGCCCCTGCTACGGGTCCTCTCTATTCGTGTTGACCACCCAAGCCAGCGGGACAACCCTGGTGTGCCAGGGAATGCAGGGCC CCCTAGCCACATAATAGGCGATGAGGAGATACCAGAAAACTGCCTGGAGCAGTTGGAGATGGGATTTCCACGGGGAGCCCAGCCAGCCCC ACTGCTGTGCTCCGTTCTGAAGGCCTCGGGTTCTCTGCAGCAGCTGTCCCTGGATAGTGCCACCTTTGCCTCTCCCCAGGATTTTGGGCT TGTTTTGCAAACACTCAAAGAGTACAACCTAGCCCTGAAAAGACTGAGCTTCCATGACATGAATCTCGCTGACTGTCAGAGCGAGGTGCT CTTTTTGCTACAGAATCTGACTCTGCAAGAGATTACCTTCTCCTTCTGCCGTCTGTTTGAGAAGCGCCCAGCCCAATTTCTGCCTGAGAT GGTTGCTGCTATGAAGGGCAACTCCACACTGAAGGGCCTCCGGCTGCCAGGGAACCGCCTGGGGAATGCTGGCCTGCTGGCCTTGGCAGA TGTTTTCTCAGAGGATTCATCCTCCTCTCTCTGTCAGCTGGACATCAGTTCCAACTGCATCAAGCCAGATGGGCTTCTGGAGTTCGCCAA GCGGCTGGAGCGCTGGGGCCGTGGAGCCTTTGGTCACCTGCGCCTCTTCCAAAACTGGCTGGACCAGGATGCAGTCACAGCCAGGGAAGC |
| * Fusion transcript sequences (Full-length transcript). |
| >In-frame_PIK3R3_ENST00000340332_chr1_46543187_-_LRRC41_ENST00000343304_chr1_46752171_-_3010nt AACCGGCCTCAGCCAATCACCACCCACCTTGCCTCTCTTCCCTCGCCCCACTCCCTCCTCGCCTGGCTCGCGTGCTCCCGGCACTGACTC CTGGAGTGCGGCCAGCGCCCGGATCGTACCATTCTGATTGAGGCTGGGGGAGAGCGCGGATGGCTGATTGGGGAGCCGAAGCCTAGAGAG CGGTGGGGAGACGTGAAAGTCGAGATGGAGAGCAGCTTTTTGAACATGTTCTCAGGCACTTGACAGAATCCCGCGCGATGTACAATACGG TGTGGAGTATGGACCGCGATGACGCAGACTGGAGGGAGGTGATGATGCCCTATTCGACAGAACTGATATTTTATATTGAAATGGATCCTC CAGCTGCGGAGGTAAATGACAAATTGCGGGATATGCCAGATGGGACCTTCTTGGTCCGAGATGCCTCAACAAAAATGCAGGGAGATTATA CTTTGACTTTGCGAGTGTGACATGTTGGCGAGCCAAGTTTATGGAGGCCTTTTTTTCCCATGTTCTACGTGGGACCATTGATGTGTCTTC TGACAGGCGTCTTTGTGATCAGCGGTTCTCACCTCTTCTGCACAGCTCCCGCCATGTCCGACAGCTCACCATCTGTAACATGCTGCAGGG TGCAACCGAGCTGGTGGCTGAGCCCAACCGCAGGGTTCTGGAGACCCTGGCCAGCTCCCTGCACACTCTCAAGTTCCGCCACCTGCTGTT CTCTGATGTGGCTGCTCAGCAGTCACTTCGGCAGCTGTTGCATCAGCTCATTCACCATGGGGCTGTCAGTCAAGTGTCGCTATACTCCTG GCCTGTGCCTGAGTCAGCCCTTTTCATCCTTATTCTCACCATGAGTGCTGGCTTCTGGCAACCAGGGCCTGGTGGCCCACCCTGCCGCCT CTGTGGAGAGGCCTCCCGAGGCCGGGCCCCATCCCGAGATGAAGGGTCCCTCTTATTGGGCTCACGTCGGCCCCGCCGGGATGCTGCTGA GCGATGTGCTGCAGCCCTGATGGCCAGCCGGCGTAAGAGTGAAGCCAAGCAGATGCCCAGAGCTGCACCTGCCACTCGGGTAACACGCCG GAGCACACAGGAGAGCCTGACAGCAGGCGGAACAGACCTTAAGAGGGAGCTGCACCCCCCAGCCACCTCCCATGAGGCTCCTGGCACCAA GCGGTCACCTTCTGCTCCAGCAGCCACCTCCTCTGCCTCTTCTTCTACATCCTCATACAAACGGGCACCAGCTAGCTCAGCCCCACAGCC TAAGCCCCTAAAGCGTTTCAAGCGAGCTGCAGGGAAGAAGGGTGCTCGCACCCGTCAGGGGCCTGGTGCAGAGTCTGAAGACCTGTATGA CTTCGTTTTTATTGTGGCTGGCGAGAAGGAGGATGGCGAAGAGATGGAGATTGGGGAAGTGGCTTGTGGAGCTTTGGATGGATCAGATCC CAGCTGCCTGGGGCTTCCAGCACTGGAAGCTTCACAAAGATTCCGCAGCATCTCCACCTTGGAGCTATTCACAGTTCCACTCTCCACAGA GGCAGCCCTGACACTATGCCACCTGCTGAGCTCCTGGGTGTCACTGGAGAGCCTCACACTCTCCTACAATGGCCTGGGCTCTAACATCTT CCGCCTGCTAGACAGCCTGCGGGCCCTGTCAGGCCAGGCTGGATGTCGCCTCCGTGCCCTGCATCTCAGTGACCTGTTCTCACCACTGCC CATCCTGGAGCTGACACGTGCTATCGTGCGAGCACTGCCCCTGCTACGGGTCCTCTCTATTCGTGTTGACCACCCAAGCCAGCGGGACAA CCCTGGTGTGCCAGGGAATGCAGGGCCCCCTAGCCACATAATAGGCGATGAGGAGATACCAGAAAACTGCCTGGAGCAGTTGGAGATGGG ATTTCCACGGGGAGCCCAGCCAGCCCCACTGCTGTGCTCCGTTCTGAAGGCCTCGGGTTCTCTGCAGCAGCTGTCCCTGGATAGTGCCAC CTTTGCCTCTCCCCAGGATTTTGGGCTTGTTTTGCAAACACTCAAAGAGTACAACCTAGCCCTGAAAAGACTGAGCTTCCATGACATGAA TCTCGCTGACTGTCAGAGCGAGGTGCTCTTTTTGCTACAGAATCTGACTCTGCAAGAGATTACCTTCTCCTTCTGCCGTCTGTTTGAGAA GCGCCCAGCCCAATTTCTGCCTGAGATGGTTGCTGCTATGAAGGGCAACTCCACACTGAAGGGCCTCCGGCTGCCAGGGAACCGCCTGGG GAATGCTGGCCTGCTGGCCTTGGCAGATGTTTTCTCAGAGGATTCATCCTCCTCTCTCTGTCAGCTGGACATCAGTTCCAACTGCATCAA GCCAGATGGGCTTCTGGAGTTCGCCAAGCGGCTGGAGCGCTGGGGCCGTGGAGCCTTTGGTCACCTGCGCCTCTTCCAAAACTGGCTGGA CCAGGATGCAGTCACAGCCAGGGAAGCCATCCGGCGGCTCCGGGCTACCTGCCATGTGGTTAGCGACTCATGGGACTCATCCCAGGCCTT CGCAGATTATGTTAGCACCATGTGATGGGGCCCGTACCTCACAGTCTCATGCTCGGTACCATCAGCTTGCAGGGGCTGAAGCATGGGCTG CCCAGAACCCCAACCACCAGTTCTATCTTTCTCTTTCTGTCACCTTTTTTCTCTTTTTTCCTTCTTCCCTTGCACTGAGGTCCTGGAGGC CTTGATGAGGCCCAGCAAACAGGCATTCTCACAGCTGGGTTTATAGTCTTTGGGCCCCTTACTCAGTATCCTGGGAACCCTGGGCCAGGA GGTTACAGTGGTCATCATAATTGCTGAAGAGATCCCCTCCCCTGCCCCTGGGTTCCTGCCTTCCCTCCTCAAGCAGGCACCCAGGCTTTA GAGAAGTATAGGGGGCTTCTTCCCTGCTGGGCTTACCACACTGCTCTCAGGCCTCAAACCCTTTCATACCTTTATTCTTTTTTTTAACCA >In-frame_PIK3R3_ENST00000420542_chr1_46543187_-_LRRC41_ENST00000343304_chr1_46752171_-_3118nt AACCGGCCTCAGCCAATCACCACCCACCTTGCCTCTCTTCCCTCGCCCCACTCCCTCCTCGCCTGGCTCGCGTGCTCCCGGCACTGACTC CTGGAGTGCGGCCAGCGCCCGGATCGTACCATTCTGATTGAGGCTGGGGGAGAGCGCGGATGGCTGATTGGGGAGCCGAAGCCTAGAGAG CGGTGGGGAGACGTGAAAGTCGAGATGGAGAGCAGCTTTTTGAACATGTTCTCAGGCACTTGACAGAATCCCGCGCGATGTACAATACGG TGTGGAGTATGGACCGCGATGACGCAGACTGGAGGGAGGTGATGATGCCCTATTCGACAGAACTGATATTTTATATTGAAATGGATCCTC CAGCTCTTCCACCAAAGCCACCTAAGCCAATGACTTCAGCAGTTCCAAATGGAATGAAGGACAGTTCTGTTTCTCTTCAGGATGCAGAAT GGTACTGGGGGGATATTTCAAGGGAGGAGGTAAATGACAAATTGCGGGATATGCCAGATGGGACCTTCTTGGTCCGAGATGCCTCAACAA AAATGCAGGGAGATTATACTTTGACTTTGCGAGTGTGACATGTTGGCGAGCCAAGTTTATGGAGGCCTTTTTTTCCCATGTTCTACGTGG GACCATTGATGTGTCTTCTGACAGGCGTCTTTGTGATCAGCGGTTCTCACCTCTTCTGCACAGCTCCCGCCATGTCCGACAGCTCACCAT CTGTAACATGCTGCAGGGTGCAACCGAGCTGGTGGCTGAGCCCAACCGCAGGGTTCTGGAGACCCTGGCCAGCTCCCTGCACACTCTCAA GTTCCGCCACCTGCTGTTCTCTGATGTGGCTGCTCAGCAGTCACTTCGGCAGCTGTTGCATCAGCTCATTCACCATGGGGCTGTCAGTCA AGTGTCGCTATACTCCTGGCCTGTGCCTGAGTCAGCCCTTTTCATCCTTATTCTCACCATGAGTGCTGGCTTCTGGCAACCAGGGCCTGG TGGCCCACCCTGCCGCCTCTGTGGAGAGGCCTCCCGAGGCCGGGCCCCATCCCGAGATGAAGGGTCCCTCTTATTGGGCTCACGTCGGCC CCGCCGGGATGCTGCTGAGCGATGTGCTGCAGCCCTGATGGCCAGCCGGCGTAAGAGTGAAGCCAAGCAGATGCCCAGAGCTGCACCTGC CACTCGGGTAACACGCCGGAGCACACAGGAGAGCCTGACAGCAGGCGGAACAGACCTTAAGAGGGAGCTGCACCCCCCAGCCACCTCCCA TGAGGCTCCTGGCACCAAGCGGTCACCTTCTGCTCCAGCAGCCACCTCCTCTGCCTCTTCTTCTACATCCTCATACAAACGGGCACCAGC TAGCTCAGCCCCACAGCCTAAGCCCCTAAAGCGTTTCAAGCGAGCTGCAGGGAAGAAGGGTGCTCGCACCCGTCAGGGGCCTGGTGCAGA GTCTGAAGACCTGTATGACTTCGTTTTTATTGTGGCTGGCGAGAAGGAGGATGGCGAAGAGATGGAGATTGGGGAAGTGGCTTGTGGAGC TTTGGATGGATCAGATCCCAGCTGCCTGGGGCTTCCAGCACTGGAAGCTTCACAAAGATTCCGCAGCATCTCCACCTTGGAGCTATTCAC AGTTCCACTCTCCACAGAGGCAGCCCTGACACTATGCCACCTGCTGAGCTCCTGGGTGTCACTGGAGAGCCTCACACTCTCCTACAATGG CCTGGGCTCTAACATCTTCCGCCTGCTAGACAGCCTGCGGGCCCTGTCAGGCCAGGCTGGATGTCGCCTCCGTGCCCTGCATCTCAGTGA CCTGTTCTCACCACTGCCCATCCTGGAGCTGACACGTGCTATCGTGCGAGCACTGCCCCTGCTACGGGTCCTCTCTATTCGTGTTGACCA CCCAAGCCAGCGGGACAACCCTGGTGTGCCAGGGAATGCAGGGCCCCCTAGCCACATAATAGGCGATGAGGAGATACCAGAAAACTGCCT GGAGCAGTTGGAGATGGGATTTCCACGGGGAGCCCAGCCAGCCCCACTGCTGTGCTCCGTTCTGAAGGCCTCGGGTTCTCTGCAGCAGCT GTCCCTGGATAGTGCCACCTTTGCCTCTCCCCAGGATTTTGGGCTTGTTTTGCAAACACTCAAAGAGTACAACCTAGCCCTGAAAAGACT GAGCTTCCATGACATGAATCTCGCTGACTGTCAGAGCGAGGTGCTCTTTTTGCTACAGAATCTGACTCTGCAAGAGATTACCTTCTCCTT CTGCCGTCTGTTTGAGAAGCGCCCAGCCCAATTTCTGCCTGAGATGGTTGCTGCTATGAAGGGCAACTCCACACTGAAGGGCCTCCGGCT GCCAGGGAACCGCCTGGGGAATGCTGGCCTGCTGGCCTTGGCAGATGTTTTCTCAGAGGATTCATCCTCCTCTCTCTGTCAGCTGGACAT CAGTTCCAACTGCATCAAGCCAGATGGGCTTCTGGAGTTCGCCAAGCGGCTGGAGCGCTGGGGCCGTGGAGCCTTTGGTCACCTGCGCCT CTTCCAAAACTGGCTGGACCAGGATGCAGTCACAGCCAGGGAAGCCATCCGGCGGCTCCGGGCTACCTGCCATGTGGTTAGCGACTCATG GGACTCATCCCAGGCCTTCGCAGATTATGTTAGCACCATGTGATGGGGCCCGTACCTCACAGTCTCATGCTCGGTACCATCAGCTTGCAG GGGCTGAAGCATGGGCTGCCCAGAACCCCAACCACCAGTTCTATCTTTCTCTTTCTGTCACCTTTTTTCTCTTTTTTCCTTCTTCCCTTG CACTGAGGTCCTGGAGGCCTTGATGAGGCCCAGCAAACAGGCATTCTCACAGCTGGGTTTATAGTCTTTGGGCCCCTTACTCAGTATCCT GGGAACCCTGGGCCAGGAGGTTACAGTGGTCATCATAATTGCTGAAGAGATCCCCTCCCCTGCCCCTGGGTTCCTGCCTTCCCTCCTCAA GCAGGCACCCAGGCTTTAGAGAAGTATAGGGGGCTTCTTCCCTGCTGGGCTTACCACACTGCTCTCAGGCCTCAAACCCTTTCATACCTT >In-frame_PIK3R3_ENST00000354242_chr1_46543187_-_LRRC41_ENST00000343304_chr1_46752171_-_3118nt AACCGGCCTCAGCCAATCACCACCCACCTTGCCTCTCTTCCCTCGCCCCACTCCCTCCTCGCCTGGCTCGCGTGCTCCCGGCACTGACTC CTGGAGTGCGGCCAGCGCCCGGATCGTACCATTCTGATTGAGGCTGGGGGAGAGCGCGGATGGCTGATTGGGGAGCCGAAGCCTAGAGAG CGGTGGGGAGACGTGAAAGTCGAGATGGAGAGCAGCTTTTTGAACATGTTCTCAGGCACTTGACAGAATCCCGCGCGATGTACAATACGG TGTGGAGTATGGACCGCGATGACGCAGACTGGAGGGAGGTGATGATGCCCTATTCGACAGAACTGATATTTTATATTGAAATGGATCCTC CAGCTCTTCCACCAAAGCCACCTAAGCCAATGACTTCAGCAGTTCCAAATGGAATGAAGGACAGTTCTGTTTCTCTTCAGGATGCAGAAT GGTACTGGGGGGATATTTCAAGGGAGGAGGTAAATGACAAATTGCGGGATATGCCAGATGGGACCTTCTTGGTCCGAGATGCCTCAACAA AAATGCAGGGAGATTATACTTTGACTTTGCGAGTGTGACATGTTGGCGAGCCAAGTTTATGGAGGCCTTTTTTTCCCATGTTCTACGTGG GACCATTGATGTGTCTTCTGACAGGCGTCTTTGTGATCAGCGGTTCTCACCTCTTCTGCACAGCTCCCGCCATGTCCGACAGCTCACCAT CTGTAACATGCTGCAGGGTGCAACCGAGCTGGTGGCTGAGCCCAACCGCAGGGTTCTGGAGACCCTGGCCAGCTCCCTGCACACTCTCAA GTTCCGCCACCTGCTGTTCTCTGATGTGGCTGCTCAGCAGTCACTTCGGCAGCTGTTGCATCAGCTCATTCACCATGGGGCTGTCAGTCA AGTGTCGCTATACTCCTGGCCTGTGCCTGAGTCAGCCCTTTTCATCCTTATTCTCACCATGAGTGCTGGCTTCTGGCAACCAGGGCCTGG TGGCCCACCCTGCCGCCTCTGTGGAGAGGCCTCCCGAGGCCGGGCCCCATCCCGAGATGAAGGGTCCCTCTTATTGGGCTCACGTCGGCC CCGCCGGGATGCTGCTGAGCGATGTGCTGCAGCCCTGATGGCCAGCCGGCGTAAGAGTGAAGCCAAGCAGATGCCCAGAGCTGCACCTGC CACTCGGGTAACACGCCGGAGCACACAGGAGAGCCTGACAGCAGGCGGAACAGACCTTAAGAGGGAGCTGCACCCCCCAGCCACCTCCCA TGAGGCTCCTGGCACCAAGCGGTCACCTTCTGCTCCAGCAGCCACCTCCTCTGCCTCTTCTTCTACATCCTCATACAAACGGGCACCAGC TAGCTCAGCCCCACAGCCTAAGCCCCTAAAGCGTTTCAAGCGAGCTGCAGGGAAGAAGGGTGCTCGCACCCGTCAGGGGCCTGGTGCAGA GTCTGAAGACCTGTATGACTTCGTTTTTATTGTGGCTGGCGAGAAGGAGGATGGCGAAGAGATGGAGATTGGGGAAGTGGCTTGTGGAGC TTTGGATGGATCAGATCCCAGCTGCCTGGGGCTTCCAGCACTGGAAGCTTCACAAAGATTCCGCAGCATCTCCACCTTGGAGCTATTCAC AGTTCCACTCTCCACAGAGGCAGCCCTGACACTATGCCACCTGCTGAGCTCCTGGGTGTCACTGGAGAGCCTCACACTCTCCTACAATGG CCTGGGCTCTAACATCTTCCGCCTGCTAGACAGCCTGCGGGCCCTGTCAGGCCAGGCTGGATGTCGCCTCCGTGCCCTGCATCTCAGTGA CCTGTTCTCACCACTGCCCATCCTGGAGCTGACACGTGCTATCGTGCGAGCACTGCCCCTGCTACGGGTCCTCTCTATTCGTGTTGACCA CCCAAGCCAGCGGGACAACCCTGGTGTGCCAGGGAATGCAGGGCCCCCTAGCCACATAATAGGCGATGAGGAGATACCAGAAAACTGCCT GGAGCAGTTGGAGATGGGATTTCCACGGGGAGCCCAGCCAGCCCCACTGCTGTGCTCCGTTCTGAAGGCCTCGGGTTCTCTGCAGCAGCT GTCCCTGGATAGTGCCACCTTTGCCTCTCCCCAGGATTTTGGGCTTGTTTTGCAAACACTCAAAGAGTACAACCTAGCCCTGAAAAGACT GAGCTTCCATGACATGAATCTCGCTGACTGTCAGAGCGAGGTGCTCTTTTTGCTACAGAATCTGACTCTGCAAGAGATTACCTTCTCCTT CTGCCGTCTGTTTGAGAAGCGCCCAGCCCAATTTCTGCCTGAGATGGTTGCTGCTATGAAGGGCAACTCCACACTGAAGGGCCTCCGGCT GCCAGGGAACCGCCTGGGGAATGCTGGCCTGCTGGCCTTGGCAGATGTTTTCTCAGAGGATTCATCCTCCTCTCTCTGTCAGCTGGACAT CAGTTCCAACTGCATCAAGCCAGATGGGCTTCTGGAGTTCGCCAAGCGGCTGGAGCGCTGGGGCCGTGGAGCCTTTGGTCACCTGCGCCT CTTCCAAAACTGGCTGGACCAGGATGCAGTCACAGCCAGGGAAGCCATCCGGCGGCTCCGGGCTACCTGCCATGTGGTTAGCGACTCATG GGACTCATCCCAGGCCTTCGCAGATTATGTTAGCACCATGTGATGGGGCCCGTACCTCACAGTCTCATGCTCGGTACCATCAGCTTGCAG GGGCTGAAGCATGGGCTGCCCAGAACCCCAACCACCAGTTCTATCTTTCTCTTTCTGTCACCTTTTTTCTCTTTTTTCCTTCTTCCCTTG CACTGAGGTCCTGGAGGCCTTGATGAGGCCCAGCAAACAGGCATTCTCACAGCTGGGTTTATAGTCTTTGGGCCCCTTACTCAGTATCCT GGGAACCCTGGGCCAGGAGGTTACAGTGGTCATCATAATTGCTGAAGAGATCCCCTCCCCTGCCCCTGGGTTCCTGCCTTCCCTCCTCAA GCAGGCACCCAGGCTTTAGAGAAGTATAGGGGGCTTCTTCCCTGCTGGGCTTACCACACTGCTCTCAGGCCTCAAACCCTTTCATACCTT >In-frame_PIK3R3_ENST00000372006_chr1_46527601_-_LRRC41_ENST00000343304_chr1_46747057_-_2273nt ACAGAATCCCGGTACATCGAGGCGGGACGGCGTGGAAGGGGCGGTGGTGATGCCTGCTGTCCCCCCTCCCGGCGCGGTTGGGTGGCGCCT CAGCGGCGCGATGTACAATACGGTGTGGAGTATGGACCGCGATGACGCAGACTGGAGGGAGGTGATGATGCCCTATTCGACAGAACTGAT ATTTTATATTGAAATGGATCCTCCAGCTCTTCCACCAAAGCCACCTAAGCCAATGACTTCAGCAGTTCCAAATGGAATGAAGGACAGTTC TGTTTCTCTTCAGGATGCAGAATGGTACTGGGGGGATATTTCAAGGGAGGAGGTAAATGACAAATTGCGGGATATGCCAGATGGGACCTT CTTGGTCCGAGATGCCTCAACAAAAATGCAGGGAGATTATACTTTGACTTTGCGGAAGGGAGGCAATAATAAGTTAATAAAGATCTATCA CCGGGATGGTAAATATGGCTTTTCTGATCCTCTGACATTTAATTCCGTGGTGGAGCTCATTAACCACTATCACCATGAATCTCTTGCTCA GTACAATCCCAAACTTGATGTGAAGCTGATGTACCCAGTGTCCAGATACCAACAGGATCAGTTGGTAAAAGAAGATAATATTGATGCAGT AGGTAAAAAACTGCAAGAATACCACTCTCAGTATCAGGAGAAGAGTAAAGAGTATGATAGGCTGTATGAAGAATATACTAGAACATCCCA GGAAATACAGATGAAGAGGACTGCAATAGAAGCTTTTAATGAAACAATTAAAATATTTGAAGAGCAGTGTCACACACAAGAACAACATAG CAAAGAATATATTGAGCGATTTCGCAGAGAGGGGAATGAAAAGGAGATTGAACGGCCTGGGCTCTAACATCTTCCGCCTGCTAGACAGCC TGCGGGCCCTGTCAGGCCAGGCTGGATGTCGCCTCCGTGCCCTGCATCTCAGTGACCTGTTCTCACCACTGCCCATCCTGGAGCTGACAC GTGCTATCGTGCGAGCACTGCCCCTGCTACGGGTCCTCTCTATTCGTGTTGACCACCCAAGCCAGCGGGACAACCCTGGTGTGCCAGGGA ATGCAGGGCCCCCTAGCCACATAATAGGCGATGAGGAGATACCAGAAAACTGCCTGGAGCAGTTGGAGATGGGATTTCCACGGGGAGCCC AGCCAGCCCCACTGCTGTGCTCCGTTCTGAAGGCCTCGGGTTCTCTGCAGCAGCTGTCCCTGGATAGTGCCACCTTTGCCTCTCCCCAGG ATTTTGGGCTTGTTTTGCAAACACTCAAAGAGTACAACCTAGCCCTGAAAAGACTGAGCTTCCATGACATGAATCTCGCTGACTGTCAGA GCGAGGTGCTCTTTTTGCTACAGAATCTGACTCTGCAAGAGATTACCTTCTCCTTCTGCCGTCTGTTTGAGAAGCGCCCAGCCCAATTTC TGCCTGAGATGGTTGCTGCTATGAAGGGCAACTCCACACTGAAGGGCCTCCGGCTGCCAGGGAACCGCCTGGGGAATGCTGGCCTGCTGG CCTTGGCAGATGTTTTCTCAGAGGATTCATCCTCCTCTCTCTGTCAGCTGGACATCAGTTCCAACTGCATCAAGCCAGATGGGCTTCTGG AGTTCGCCAAGCGGCTGGAGCGCTGGGGCCGTGGAGCCTTTGGTCACCTGCGCCTCTTCCAAAACTGGCTGGACCAGGATGCAGTCACAG CCAGGGAAGCCATCCGGCGGCTCCGGGCTACCTGCCATGTGGTTAGCGACTCATGGGACTCATCCCAGGCCTTCGCAGATTATGTTAGCA CCATGTGATGGGGCCCGTACCTCACAGTCTCATGCTCGGTACCATCAGCTTGCAGGGGCTGAAGCATGGGCTGCCCAGAACCCCAACCAC CAGTTCTATCTTTCTCTTTCTGTCACCTTTTTTCTCTTTTTTCCTTCTTCCCTTGCACTGAGGTCCTGGAGGCCTTGATGAGGCCCAGCA AACAGGCATTCTCACAGCTGGGTTTATAGTCTTTGGGCCCCTTACTCAGTATCCTGGGAACCCTGGGCCAGGAGGTTACAGTGGTCATCA TAATTGCTGAAGAGATCCCCTCCCCTGCCCCTGGGTTCCTGCCTTCCCTCCTCAAGCAGGCACCCAGGCTTTAGAGAAGTATAGGGGGCT TCTTCCCTGCTGGGCTTACCACACTGCTCTCAGGCCTCAAACCCTTTCATACCTTTATTCTTTTTTTTAACCAAAAAAGTTTTTCTTATA |
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FusionGenePPI for PIK3R3_LRRC41 |
| Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in . |
| Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160) |
| Hgene | Hgene's interactors | Tgene | Tgene's interactors |
| PIK3R3 | PIK3CA, DRAP1, RB1, IRS2, IRS1, IGF1R, ABCB6, RING1, AMBP, ORM1, SERF1A, GC, KARS, MICAL1, DSN1, VBP1, QARS, DARS, KLC2, TRMT2A, PSME1, FGB, KIAA1377, LUC7L2, FBN3, PIK3R2, CRK, GRB2, EGFR, ERBB2, ERBB3, MBIP, LYN, KHDRBS1, IRS4, TRIM54, L3MBTL3, FSD2, EFNB2, SOCS6, TGFBR2, BTN2A1, SKAP1, VSIG4, RELT, HEPACAM2, ABL2, HCK, NCK1, ARL6IP4, PLEKHS1, CCDC14, IQUB, OTUD7B, PARD6A, PCDHB5, PELI3, PELO, PLB1, RBP7, SOCS4, SPSB2, USP2, WBSCR27, ZNF281, ZNF767P, SRC, STAT3, CBL, BTK, CRYBA2, E2F6, MECOM, ANKS1A, FRS3, HSH2D, CLNK, SH2D2A, PPARA, VCP, FER, C17orf53, AUNIP, BRK1, CEP19, CAMK1, CCDC33, CRBN, KLF15, KMT2B, MTF2, OLIG1, PACRGL, WDFY3, DCAF8, WRNIP1, ZMAT1, ZNF451, FOXO1, FYN, PIK3CB, PPP1R12B, PTK2, TERF2, TNNC2, TSPAN2, LNX2, PDGFRB, PTP4A3, PIK3CD, EHD2, HAVCR2, NISCH, PIK3R1, ALDH3B1, TMEM52B, NLGN3, FLRT1 | LRRC41 | RBPMS, MYO9B, TCEB2, TCEB1, CUL5, DCUN1D1, BARD1, NXF1, DRG1, FBL, LIPH, PPP3CC, NTRK1, CPSF3, TEAD2, POU5F1, EXOC8, UNC5CL, ERCC3, TRIM25 |
| - Retained PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
| - Lost PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
| - Retained PPIs, but lost function due to frame-shift fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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RelatedDrugs for PIK3R3_LRRC41 |
| Drugs targeting genes involved in this fusion gene. (DrugBank Version 5.1.0 2018-04-02) |
| Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
| Hgene | PIK3R3 | Q92569 | DB01064 | Isoprenaline | Phosphatidylinositol 3-kinase regulatory subunit gamma | small molecule | approved|investigational |
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RelatedDiseases for PIK3R3_LRRC41 |
| Diseases associated with fusion partners. (DisGeNet 4.0) |
| Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
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