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Fusion gene ID: 27206 |
FusionGeneSummary for PIK3R1_NDUFB7 |
 Fusion gene summary |
| Fusion gene information | Fusion gene name: PIK3R1_NDUFB7 | Fusion gene ID: 27206 | Hgene | Tgene | Gene symbol | PIK3R1 | NDUFB7 | Gene ID | 5295 | 4713 |
| Gene name | phosphoinositide-3-kinase regulatory subunit 1 | NADH:ubiquinone oxidoreductase subunit B7 | |
| Synonyms | AGM7|GRB1|IMD36|p85|p85-ALPHA | B18|CI-B18 | |
| Cytomap | 5q13.1 | 19p13.12 | |
| Type of gene | protein-coding | protein-coding | |
| Description | phosphatidylinositol 3-kinase regulatory subunit alphaPI3-kinase subunit p85-alphaPI3K regulatory subunit alphaphosphatidylinositol 3-kinase 85 kDa regulatory subunit alphaphosphatidylinositol 3-kinase, regulatory subunit, polypeptide 1 (p85 alpha)ph | NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 7NADH dehydrogenase (ubiquinone) 1 beta subcomplex, 7, 18kDaNADH-ubiquinone oxidoreductase B18 subunitcell adhesion protein SQM1complex I B18 subunitcomplex I-B18 | |
| Modification date | 20180523 | 20180522 | |
| UniProtAcc | P27986 | P17568 | |
| Ensembl transtripts involved in fusion gene | ENST00000521381, ENST00000521657, ENST00000517643, ENST00000274335, ENST00000396611, ENST00000320694, ENST00000336483, ENST00000523872, | ENST00000215565, | |
| Fusion gene scores | * DoF score | 5 X 3 X 5=75 | 4 X 2 X 4=32 |
| # samples | 5 | 4 | |
| ** MAII score | log2(5/75*10)=-0.584962500721156 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | log2(4/32*10)=0.321928094887362 effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs). DoF>8 and MAII>0 | |
| Context | PubMed: PIK3R1 [Title/Abstract] AND NDUFB7 [Title/Abstract] AND fusion [Title/Abstract] | ||
| Functional or gene categories assigned by FusionGDB annotation | Oncogene involved fusion gene, in-frame and retained their domain. | ||
| * DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
| Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Partner | Gene | GO ID | GO term | PubMed ID |
| Hgene | PIK3R1 | GO:0014065 | phosphatidylinositol 3-kinase signaling | 7782332 |
| Hgene | PIK3R1 | GO:0034976 | response to endoplasmic reticulum stress | 20348923 |
| Hgene | PIK3R1 | GO:0042307 | positive regulation of protein import into nucleus | 20348923 |
| Hgene | PIK3R1 | GO:0048009 | insulin-like growth factor receptor signaling pathway | 7782332 |
| Hgene | PIK3R1 | GO:0050821 | protein stabilization | 20348923 |
| Hgene | PIK3R1 | GO:0060396 | growth hormone receptor signaling pathway | 7782332 |
| Fusion gene information from three resources (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| TCGA | RV | BRCA | TCGA-B6-A1KF-01A | PIK3R1 | chr5 | 67576834 | + | NDUFB7 | chr19 | 14677745 | - |
| * LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
| Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| In-frame | ENST00000521381 | ENST00000215565 | PIK3R1 | chr5 | 67576834 | + | NDUFB7 | chr19 | 14677745 | - |
| In-frame | ENST00000521657 | ENST00000215565 | PIK3R1 | chr5 | 67576834 | + | NDUFB7 | chr19 | 14677745 | - |
| intron-3CDS | ENST00000517643 | ENST00000215565 | PIK3R1 | chr5 | 67576834 | + | NDUFB7 | chr19 | 14677745 | - |
| In-frame | ENST00000274335 | ENST00000215565 | PIK3R1 | chr5 | 67576834 | + | NDUFB7 | chr19 | 14677745 | - |
| In-frame | ENST00000396611 | ENST00000215565 | PIK3R1 | chr5 | 67576834 | + | NDUFB7 | chr19 | 14677745 | - |
| intron-3CDS | ENST00000320694 | ENST00000215565 | PIK3R1 | chr5 | 67576834 | + | NDUFB7 | chr19 | 14677745 | - |
| intron-3CDS | ENST00000336483 | ENST00000215565 | PIK3R1 | chr5 | 67576834 | + | NDUFB7 | chr19 | 14677745 | - |
| intron-3CDS | ENST00000523872 | ENST00000215565 | PIK3R1 | chr5 | 67576834 | + | NDUFB7 | chr19 | 14677745 | - |
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FusionProtFeatures for PIK3R1_NDUFB7 |
| Main function of each fusion partner protein. (from UniProt) |
| Hgene | Tgene |
| PIK3R1 | NDUFB7 |
| Accessory subunit of the mitochondrial membranerespiratory chain NADH dehydrogenase (Complex I), that is believednot to be involved in catalysis. Complex I functions in thetransfer of electrons from NADH to the respiratory chain. Theimmediate electron acceptor for the enzyme is believed to beubiquinone. {ECO:0000269|PubMed:27626371}. |
| Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at . * Minus value of BPloci means that the break pointn is located before the CDS. |
| - In-frame and retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
| Hgene | PIK3R1 | chr5:67576834 | chr19:14677745 | ENST00000274335 | + | 6 | 15 | 113_301 | 305 | 725 | Domain | Rho-GAP |
| Hgene | PIK3R1 | chr5:67576834 | chr19:14677745 | ENST00000274335 | + | 6 | 15 | 3_79 | 305 | 725 | Domain | SH3 |
| Hgene | PIK3R1 | chr5:67576834 | chr19:14677745 | ENST00000396611 | + | 6 | 15 | 113_301 | 305 | 733 | Domain | Rho-GAP |
| Hgene | PIK3R1 | chr5:67576834 | chr19:14677745 | ENST00000396611 | + | 6 | 15 | 3_79 | 305 | 733 | Domain | SH3 |
| Hgene | PIK3R1 | chr5:67576834 | chr19:14677745 | ENST00000521381 | + | 7 | 16 | 113_301 | 305 | 725 | Domain | Rho-GAP |
| Hgene | PIK3R1 | chr5:67576834 | chr19:14677745 | ENST00000521381 | + | 7 | 16 | 3_79 | 305 | 725 | Domain | SH3 |
| Hgene | PIK3R1 | chr5:67576834 | chr19:14677745 | ENST00000521657 | + | 7 | 16 | 113_301 | 305 | 725 | Domain | Rho-GAP |
| Hgene | PIK3R1 | chr5:67576834 | chr19:14677745 | ENST00000521657 | + | 7 | 16 | 3_79 | 305 | 725 | Domain | SH3 |
| Tgene | >NDUFB7 | chr5:67576834 | chr19:14677745 | ENST00000215565 | - | 0 | 3 | 56_98 | 37 | 138 | Domain | CHCH |
| Tgene | >NDUFB7 | chr5:67576834 | chr19:14677745 | ENST00000215565 | - | 0 | 3 | 59_69 | 37 | 138 | Motif | Cx9C motif 1 |
| Tgene | >NDUFB7 | chr5:67576834 | chr19:14677745 | ENST00000215565 | - | 0 | 3 | 80_90 | 37 | 138 | Motif | Cx9C motif 2 |
| - In-frame and not-retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
| Hgene | >PIK3R1 | chr5:67576834 | chr19:14677745 | ENST00000274335 | + | 6 | 15 | 333_428 | 305 | 725 | Domain | SH2 1 |
| Hgene | >PIK3R1 | chr5:67576834 | chr19:14677745 | ENST00000274335 | + | 6 | 15 | 624_718 | 305 | 725 | Domain | SH2 2 |
| Hgene | >PIK3R1 | chr5:67576834 | chr19:14677745 | ENST00000320694 | + | 1 | 10 | 113_301 | -123 | 425 | Domain | Rho-GAP |
| Hgene | >PIK3R1 | chr5:67576834 | chr19:14677745 | ENST00000320694 | + | 1 | 10 | 333_428 | -123 | 425 | Domain | SH2 1 |
| Hgene | >PIK3R1 | chr5:67576834 | chr19:14677745 | ENST00000320694 | + | 1 | 10 | 3_79 | -123 | 425 | Domain | SH3 |
| Hgene | >PIK3R1 | chr5:67576834 | chr19:14677745 | ENST00000320694 | + | 1 | 10 | 624_718 | -123 | 425 | Domain | SH2 2 |
| Hgene | >PIK3R1 | chr5:67576834 | chr19:14677745 | ENST00000336483 | + | 1 | 10 | 113_301 | -31 | 455 | Domain | Rho-GAP |
| Hgene | >PIK3R1 | chr5:67576834 | chr19:14677745 | ENST00000336483 | + | 1 | 10 | 333_428 | -31 | 455 | Domain | SH2 1 |
| Hgene | >PIK3R1 | chr5:67576834 | chr19:14677745 | ENST00000336483 | + | 1 | 10 | 3_79 | -31 | 455 | Domain | SH3 |
| Hgene | >PIK3R1 | chr5:67576834 | chr19:14677745 | ENST00000336483 | + | 1 | 10 | 624_718 | -31 | 455 | Domain | SH2 2 |
| Hgene | >PIK3R1 | chr5:67576834 | chr19:14677745 | ENST00000396611 | + | 6 | 15 | 333_428 | 305 | 733 | Domain | SH2 1 |
| Hgene | >PIK3R1 | chr5:67576834 | chr19:14677745 | ENST00000396611 | + | 6 | 15 | 624_718 | 305 | 733 | Domain | SH2 2 |
| Hgene | >PIK3R1 | chr5:67576834 | chr19:14677745 | ENST00000521381 | + | 7 | 16 | 333_428 | 305 | 725 | Domain | SH2 1 |
| Hgene | >PIK3R1 | chr5:67576834 | chr19:14677745 | ENST00000521381 | + | 7 | 16 | 624_718 | 305 | 725 | Domain | SH2 2 |
| Hgene | >PIK3R1 | chr5:67576834 | chr19:14677745 | ENST00000521657 | + | 7 | 16 | 333_428 | 305 | 725 | Domain | SH2 1 |
| Hgene | >PIK3R1 | chr5:67576834 | chr19:14677745 | ENST00000521657 | + | 7 | 16 | 624_718 | 305 | 725 | Domain | SH2 2 |
| Hgene | >PIK3R1 | chr5:67576834 | chr19:14677745 | ENST00000523872 | + | 1 | 9 | 113_301 | -78 | 362 | Domain | Rho-GAP |
| Hgene | >PIK3R1 | chr5:67576834 | chr19:14677745 | ENST00000523872 | + | 1 | 9 | 333_428 | -78 | 362 | Domain | SH2 1 |
| Hgene | >PIK3R1 | chr5:67576834 | chr19:14677745 | ENST00000523872 | + | 1 | 9 | 3_79 | -78 | 362 | Domain | SH3 |
| Hgene | >PIK3R1 | chr5:67576834 | chr19:14677745 | ENST00000523872 | + | 1 | 9 | 624_718 | -78 | 362 | Domain | SH2 2 |
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FusionGeneSequence for PIK3R1_NDUFB7 |
| For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. (nt: nucleotides, aa: amino acids) |
| * Fusion amino acid sequences. |
| >In-frame_PIK3R1_ENST00000521381_chr5_67576834_+_NDUFB7_ENST00000215565_chr19_14677745_-_406aa MSAEGYQYRALYDYKKEREEDIDLHLGDILTVNKGSLVALGFSDGQEARPEEIGWLNGYNETTGERGDFPGTYVEYIGRKKISPPTPKPR PPRPLPVAPGSSKTEADVEQQALTLPDLAEQFAPPDIAPPLLIKLVEAIEKKGLECSTLYRTQSSSNLAELRQLLDCDTPSVDLEMIDVH VLADAFKRYLLDLPNPVIPAAVYSEMISLAPEVQSSEEYIQLLKKLIRSPSIPHQYWLTLQYLLKHFFKLSQTSSKNLLNARVLSEIFSP MLFRFSAASSDNTENLIKVIEILISTEWNERQPAPEMVATQQEMMDAQLRLQLRDYCAHHLIRLLKCKRDSFPNFLACKQERHDWDYCEH >In-frame_PIK3R1_ENST00000521657_chr5_67576834_+_NDUFB7_ENST00000215565_chr19_14677745_-_406aa MSAEGYQYRALYDYKKEREEDIDLHLGDILTVNKGSLVALGFSDGQEARPEEIGWLNGYNETTGERGDFPGTYVEYIGRKKISPPTPKPR PPRPLPVAPGSSKTEADVEQQALTLPDLAEQFAPPDIAPPLLIKLVEAIEKKGLECSTLYRTQSSSNLAELRQLLDCDTPSVDLEMIDVH VLADAFKRYLLDLPNPVIPAAVYSEMISLAPEVQSSEEYIQLLKKLIRSPSIPHQYWLTLQYLLKHFFKLSQTSSKNLLNARVLSEIFSP MLFRFSAASSDNTENLIKVIEILISTEWNERQPAPEMVATQQEMMDAQLRLQLRDYCAHHLIRLLKCKRDSFPNFLACKQERHDWDYCEH >In-frame_PIK3R1_ENST00000274335_chr5_67576834_+_NDUFB7_ENST00000215565_chr19_14677745_-_406aa MSAEGYQYRALYDYKKEREEDIDLHLGDILTVNKGSLVALGFSDGQEARPEEIGWLNGYNETTGERGDFPGTYVEYIGRKKISPPTPKPR PPRPLPVAPGSSKTEADVEQQALTLPDLAEQFAPPDIAPPLLIKLVEAIEKKGLECSTLYRTQSSSNLAELRQLLDCDTPSVDLEMIDVH VLADAFKRYLLDLPNPVIPAAVYSEMISLAPEVQSSEEYIQLLKKLIRSPSIPHQYWLTLQYLLKHFFKLSQTSSKNLLNARVLSEIFSP MLFRFSAASSDNTENLIKVIEILISTEWNERQPAPEMVATQQEMMDAQLRLQLRDYCAHHLIRLLKCKRDSFPNFLACKQERHDWDYCEH >In-frame_PIK3R1_ENST00000396611_chr5_67576834_+_NDUFB7_ENST00000215565_chr19_14677745_-_406aa MSAEGYQYRALYDYKKEREEDIDLHLGDILTVNKGSLVALGFSDGQEARPEEIGWLNGYNETTGERGDFPGTYVEYIGRKKISPPTPKPR PPRPLPVAPGSSKTEADVEQQALTLPDLAEQFAPPDIAPPLLIKLVEAIEKKGLECSTLYRTQSSSNLAELRQLLDCDTPSVDLEMIDVH VLADAFKRYLLDLPNPVIPAAVYSEMISLAPEVQSSEEYIQLLKKLIRSPSIPHQYWLTLQYLLKHFFKLSQTSSKNLLNARVLSEIFSP MLFRFSAASSDNTENLIKVIEILISTEWNERQPAPEMVATQQEMMDAQLRLQLRDYCAHHLIRLLKCKRDSFPNFLACKQERHDWDYCEH |
| * Fusion transcript sequences (only coding sequence (CDS) region). |
| >In-frame_PIK3R1_ENST00000521381_chr5_67576834_+_NDUFB7_ENST00000215565_chr19_14677745_-_1218nt ATGAGTGCTGAGGGGTACCAGTACAGAGCGCTGTATGATTATAAAAAGGAAAGAGAAGAAGATATTGACTTGCACTTGGGTGACATATTG ACTGTGAATAAAGGGTCCTTAGTAGCTCTTGGATTCAGTGATGGACAGGAAGCCAGGCCTGAAGAAATTGGCTGGTTAAATGGCTATAAT GAAACCACAGGGGAAAGGGGGGACTTTCCGGGAACTTACGTAGAATATATTGGAAGGAAAAAAATCTCGCCTCCCACACCAAAGCCCCGG CCACCTCGGCCTCTTCCTGTTGCACCAGGTTCTTCGAAAACTGAAGCAGATGTTGAACAACAAGCTTTGACTCTCCCGGATCTTGCAGAG CAGTTTGCCCCTCCTGACATTGCCCCGCCTCTTCTTATCAAGCTCGTGGAAGCCATTGAAAAGAAAGGTCTGGAATGTTCAACTCTATAC AGAACACAGAGCTCCAGCAACCTGGCAGAATTACGACAGCTTCTTGATTGTGATACACCCTCCGTGGACTTGGAAATGATCGATGTGCAC GTTTTGGCTGACGCTTTCAAACGCTATCTCCTGGACTTACCAAATCCTGTCATTCCAGCAGCCGTTTACAGTGAAATGATTTCTTTAGCT CCAGAAGTACAAAGCTCCGAAGAATATATTCAGCTATTGAAGAAGCTTATTAGGTCGCCTAGCATACCTCATCAGTATTGGCTTACGCTT CAGTATTTGTTAAAACATTTCTTCAAGCTCTCTCAAACCTCCAGCAAAAATCTGTTGAATGCAAGAGTACTCTCTGAAATTTTCAGCCCT ATGCTTTTCAGATTCTCAGCAGCCAGCTCTGATAATACTGAAAACCTCATAAAAGTTATAGAAATTTTAATCTCAACTGAATGGAATGAA CGACAGCCTGCACCAGAGATGGTGGCCACACAGCAGGAGATGATGGACGCGCAGCTGAGGCTCCAGCTGCGGGACTACTGCGCCCACCAC CTCATCCGGCTGCTCAAGTGCAAGCGTGACAGCTTCCCCAACTTCCTGGCCTGCAAGCAGGAGCGGCACGACTGGGACTACTGCGAGCAC CGCGACTATGTGATGCGCATGAAGGAGTTTGAGCGGGAGCGGAGGCTGCTCCAGCGGAAGAAGCGGCGGGAGAAGAAGGCGGCAGAGTTG >In-frame_PIK3R1_ENST00000521657_chr5_67576834_+_NDUFB7_ENST00000215565_chr19_14677745_-_1218nt ATGAGTGCTGAGGGGTACCAGTACAGAGCGCTGTATGATTATAAAAAGGAAAGAGAAGAAGATATTGACTTGCACTTGGGTGACATATTG ACTGTGAATAAAGGGTCCTTAGTAGCTCTTGGATTCAGTGATGGACAGGAAGCCAGGCCTGAAGAAATTGGCTGGTTAAATGGCTATAAT GAAACCACAGGGGAAAGGGGGGACTTTCCGGGAACTTACGTAGAATATATTGGAAGGAAAAAAATCTCGCCTCCCACACCAAAGCCCCGG CCACCTCGGCCTCTTCCTGTTGCACCAGGTTCTTCGAAAACTGAAGCAGATGTTGAACAACAAGCTTTGACTCTCCCGGATCTTGCAGAG CAGTTTGCCCCTCCTGACATTGCCCCGCCTCTTCTTATCAAGCTCGTGGAAGCCATTGAAAAGAAAGGTCTGGAATGTTCAACTCTATAC AGAACACAGAGCTCCAGCAACCTGGCAGAATTACGACAGCTTCTTGATTGTGATACACCCTCCGTGGACTTGGAAATGATCGATGTGCAC GTTTTGGCTGACGCTTTCAAACGCTATCTCCTGGACTTACCAAATCCTGTCATTCCAGCAGCCGTTTACAGTGAAATGATTTCTTTAGCT CCAGAAGTACAAAGCTCCGAAGAATATATTCAGCTATTGAAGAAGCTTATTAGGTCGCCTAGCATACCTCATCAGTATTGGCTTACGCTT CAGTATTTGTTAAAACATTTCTTCAAGCTCTCTCAAACCTCCAGCAAAAATCTGTTGAATGCAAGAGTACTCTCTGAAATTTTCAGCCCT ATGCTTTTCAGATTCTCAGCAGCCAGCTCTGATAATACTGAAAACCTCATAAAAGTTATAGAAATTTTAATCTCAACTGAATGGAATGAA CGACAGCCTGCACCAGAGATGGTGGCCACACAGCAGGAGATGATGGACGCGCAGCTGAGGCTCCAGCTGCGGGACTACTGCGCCCACCAC CTCATCCGGCTGCTCAAGTGCAAGCGTGACAGCTTCCCCAACTTCCTGGCCTGCAAGCAGGAGCGGCACGACTGGGACTACTGCGAGCAC CGCGACTATGTGATGCGCATGAAGGAGTTTGAGCGGGAGCGGAGGCTGCTCCAGCGGAAGAAGCGGCGGGAGAAGAAGGCGGCAGAGTTG >In-frame_PIK3R1_ENST00000274335_chr5_67576834_+_NDUFB7_ENST00000215565_chr19_14677745_-_1218nt ATGAGTGCTGAGGGGTACCAGTACAGAGCGCTGTATGATTATAAAAAGGAAAGAGAAGAAGATATTGACTTGCACTTGGGTGACATATTG ACTGTGAATAAAGGGTCCTTAGTAGCTCTTGGATTCAGTGATGGACAGGAAGCCAGGCCTGAAGAAATTGGCTGGTTAAATGGCTATAAT GAAACCACAGGGGAAAGGGGGGACTTTCCGGGAACTTACGTAGAATATATTGGAAGGAAAAAAATCTCGCCTCCCACACCAAAGCCCCGG CCACCTCGGCCTCTTCCTGTTGCACCAGGTTCTTCGAAAACTGAAGCAGATGTTGAACAACAAGCTTTGACTCTCCCGGATCTTGCAGAG CAGTTTGCCCCTCCTGACATTGCCCCGCCTCTTCTTATCAAGCTCGTGGAAGCCATTGAAAAGAAAGGTCTGGAATGTTCAACTCTATAC AGAACACAGAGCTCCAGCAACCTGGCAGAATTACGACAGCTTCTTGATTGTGATACACCCTCCGTGGACTTGGAAATGATCGATGTGCAC GTTTTGGCTGACGCTTTCAAACGCTATCTCCTGGACTTACCAAATCCTGTCATTCCAGCAGCCGTTTACAGTGAAATGATTTCTTTAGCT CCAGAAGTACAAAGCTCCGAAGAATATATTCAGCTATTGAAGAAGCTTATTAGGTCGCCTAGCATACCTCATCAGTATTGGCTTACGCTT CAGTATTTGTTAAAACATTTCTTCAAGCTCTCTCAAACCTCCAGCAAAAATCTGTTGAATGCAAGAGTACTCTCTGAAATTTTCAGCCCT ATGCTTTTCAGATTCTCAGCAGCCAGCTCTGATAATACTGAAAACCTCATAAAAGTTATAGAAATTTTAATCTCAACTGAATGGAATGAA CGACAGCCTGCACCAGAGATGGTGGCCACACAGCAGGAGATGATGGACGCGCAGCTGAGGCTCCAGCTGCGGGACTACTGCGCCCACCAC CTCATCCGGCTGCTCAAGTGCAAGCGTGACAGCTTCCCCAACTTCCTGGCCTGCAAGCAGGAGCGGCACGACTGGGACTACTGCGAGCAC CGCGACTATGTGATGCGCATGAAGGAGTTTGAGCGGGAGCGGAGGCTGCTCCAGCGGAAGAAGCGGCGGGAGAAGAAGGCGGCAGAGTTG >In-frame_PIK3R1_ENST00000396611_chr5_67576834_+_NDUFB7_ENST00000215565_chr19_14677745_-_1218nt ATGAGTGCTGAGGGGTACCAGTACAGAGCGCTGTATGATTATAAAAAGGAAAGAGAAGAAGATATTGACTTGCACTTGGGTGACATATTG ACTGTGAATAAAGGGTCCTTAGTAGCTCTTGGATTCAGTGATGGACAGGAAGCCAGGCCTGAAGAAATTGGCTGGTTAAATGGCTATAAT GAAACCACAGGGGAAAGGGGGGACTTTCCGGGAACTTACGTAGAATATATTGGAAGGAAAAAAATCTCGCCTCCCACACCAAAGCCCCGG CCACCTCGGCCTCTTCCTGTTGCACCAGGTTCTTCGAAAACTGAAGCAGATGTTGAACAACAAGCTTTGACTCTCCCGGATCTTGCAGAG CAGTTTGCCCCTCCTGACATTGCCCCGCCTCTTCTTATCAAGCTCGTGGAAGCCATTGAAAAGAAAGGTCTGGAATGTTCAACTCTATAC AGAACACAGAGCTCCAGCAACCTGGCAGAATTACGACAGCTTCTTGATTGTGATACACCCTCCGTGGACTTGGAAATGATCGATGTGCAC GTTTTGGCTGACGCTTTCAAACGCTATCTCCTGGACTTACCAAATCCTGTCATTCCAGCAGCCGTTTACAGTGAAATGATTTCTTTAGCT CCAGAAGTACAAAGCTCCGAAGAATATATTCAGCTATTGAAGAAGCTTATTAGGTCGCCTAGCATACCTCATCAGTATTGGCTTACGCTT CAGTATTTGTTAAAACATTTCTTCAAGCTCTCTCAAACCTCCAGCAAAAATCTGTTGAATGCAAGAGTACTCTCTGAAATTTTCAGCCCT ATGCTTTTCAGATTCTCAGCAGCCAGCTCTGATAATACTGAAAACCTCATAAAAGTTATAGAAATTTTAATCTCAACTGAATGGAATGAA CGACAGCCTGCACCAGAGATGGTGGCCACACAGCAGGAGATGATGGACGCGCAGCTGAGGCTCCAGCTGCGGGACTACTGCGCCCACCAC CTCATCCGGCTGCTCAAGTGCAAGCGTGACAGCTTCCCCAACTTCCTGGCCTGCAAGCAGGAGCGGCACGACTGGGACTACTGCGAGCAC CGCGACTATGTGATGCGCATGAAGGAGTTTGAGCGGGAGCGGAGGCTGCTCCAGCGGAAGAAGCGGCGGGAGAAGAAGGCGGCAGAGTTG |
| * Fusion transcript sequences (Full-length transcript). |
| >In-frame_PIK3R1_ENST00000521381_chr5_67576834_+_NDUFB7_ENST00000215565_chr19_14677745_-_1889nt GCGCCGGGCGCTGGAGCTGCGGGCGCACGGAGAGGAGTCGCCAGCAGCTGGAGCGGAGTTGGAGGAAGCAGCGGCAGCGGCGAGGGCGGC AGGCTAGCTGTCGGAGACGGCAAGCACGGATCGGGCACGGCCGGCGGGTCGCAGCCGGGCTGGAGGCCGGTCGGAACCGAGCGGGCAGGA GGCCACCGCTGCAGCGCGGGCCCCGCAGAGGAAGGAAGCCGGCGGGCGGGGTGAAGCTCGTGTGTGGAGTGCCACGGTACAATCAGACGA CAGATGGACAGTGTGACAAAAGTGTCAGAAAGGATTGGGCCTCGCTGTGAGAGTCAGCCTGGATTCAAAGTGTTGACAAGTTGCTGAAAA GGAAGCCAGTGAGAGGACTGTGGCACGCAGAGGAAGTGGAGCCCTGTCTTCGGTCACACCATTGATGGAGGACAGATGGACAGCCGTATG GCCAGTCACCTCTCCTCTTAAACCTTTGGAGAGTGGTCCTTTGTCCTCTGCTGGACACATAATAGGAATTCTAACACATTCTCTGAATTC ACTTTTCATAAAAACGTAAAATCAGACTGCTCTGTACAACCAGGCTCAACTGTTGCATGGTAGCAGATTTGCAAACATGAGTGCTGAGGG GTACCAGTACAGAGCGCTGTATGATTATAAAAAGGAAAGAGAAGAAGATATTGACTTGCACTTGGGTGACATATTGACTGTGAATAAAGG GTCCTTAGTAGCTCTTGGATTCAGTGATGGACAGGAAGCCAGGCCTGAAGAAATTGGCTGGTTAAATGGCTATAATGAAACCACAGGGGA AAGGGGGGACTTTCCGGGAACTTACGTAGAATATATTGGAAGGAAAAAAATCTCGCCTCCCACACCAAAGCCCCGGCCACCTCGGCCTCT TCCTGTTGCACCAGGTTCTTCGAAAACTGAAGCAGATGTTGAACAACAAGCTTTGACTCTCCCGGATCTTGCAGAGCAGTTTGCCCCTCC TGACATTGCCCCGCCTCTTCTTATCAAGCTCGTGGAAGCCATTGAAAAGAAAGGTCTGGAATGTTCAACTCTATACAGAACACAGAGCTC CAGCAACCTGGCAGAATTACGACAGCTTCTTGATTGTGATACACCCTCCGTGGACTTGGAAATGATCGATGTGCACGTTTTGGCTGACGC TTTCAAACGCTATCTCCTGGACTTACCAAATCCTGTCATTCCAGCAGCCGTTTACAGTGAAATGATTTCTTTAGCTCCAGAAGTACAAAG CTCCGAAGAATATATTCAGCTATTGAAGAAGCTTATTAGGTCGCCTAGCATACCTCATCAGTATTGGCTTACGCTTCAGTATTTGTTAAA ACATTTCTTCAAGCTCTCTCAAACCTCCAGCAAAAATCTGTTGAATGCAAGAGTACTCTCTGAAATTTTCAGCCCTATGCTTTTCAGATT CTCAGCAGCCAGCTCTGATAATACTGAAAACCTCATAAAAGTTATAGAAATTTTAATCTCAACTGAATGGAATGAACGACAGCCTGCACC AGAGATGGTGGCCACACAGCAGGAGATGATGGACGCGCAGCTGAGGCTCCAGCTGCGGGACTACTGCGCCCACCACCTCATCCGGCTGCT CAAGTGCAAGCGTGACAGCTTCCCCAACTTCCTGGCCTGCAAGCAGGAGCGGCACGACTGGGACTACTGCGAGCACCGCGACTATGTGAT GCGCATGAAGGAGTTTGAGCGGGAGCGGAGGCTGCTCCAGCGGAAGAAGCGGCGGGAGAAGAAGGCGGCAGAGTTGGCCAAAGGCCAGGG >In-frame_PIK3R1_ENST00000521657_chr5_67576834_+_NDUFB7_ENST00000215565_chr19_14677745_-_1837nt AGTTGGAGGAAGCAGCGGCAGCGGCGAGGGCGGCAGGCTAGCTGTCGGAGACGGCAAGCACGGATCGGGCACGGCCGGCGGGTCGCAGCC GGGCTGGAGGCCGGTCGGAACCGAGCGGGCAGGAGGCCACCGCTGCAGCGCGGGCCCCGCAGAGGAAGGAAGCCGGCGGGCGGGGTAGGT GAAGCTCGTGTGTGGAGTGCCACGGTACAATCAGACGACAGATGGACAGTGTGACAAAAGTGTCAGAAAGGATTGGGCCTCGCTGTGAGA GTCAGCCTGGATTCAAAGTGTTGACAAGTTGCTGAAAAGGAAGCCAGTGAGAGGACTGTGGCACGCAGAGGAAGTGGAGCCCTGTCTTCG GTCACACCATTGATGGAGGACAGATGGACAGCCGTATGGCCAGTCACCTCTCCTCTTAAACCTTTGGAGAGTGGTCCTTTGTCCTCTGCT GGACACATAATAGGAATTCTAACACATTCTCTGAATTCACTTTTCATAAAAACGTAAAATCAGACTGCTCTGTACAACCAGGCTCAACTG TTGCATGGTAGCAGATTTGCAAACATGAGTGCTGAGGGGTACCAGTACAGAGCGCTGTATGATTATAAAAAGGAAAGAGAAGAAGATATT GACTTGCACTTGGGTGACATATTGACTGTGAATAAAGGGTCCTTAGTAGCTCTTGGATTCAGTGATGGACAGGAAGCCAGGCCTGAAGAA ATTGGCTGGTTAAATGGCTATAATGAAACCACAGGGGAAAGGGGGGACTTTCCGGGAACTTACGTAGAATATATTGGAAGGAAAAAAATC TCGCCTCCCACACCAAAGCCCCGGCCACCTCGGCCTCTTCCTGTTGCACCAGGTTCTTCGAAAACTGAAGCAGATGTTGAACAACAAGCT TTGACTCTCCCGGATCTTGCAGAGCAGTTTGCCCCTCCTGACATTGCCCCGCCTCTTCTTATCAAGCTCGTGGAAGCCATTGAAAAGAAA GGTCTGGAATGTTCAACTCTATACAGAACACAGAGCTCCAGCAACCTGGCAGAATTACGACAGCTTCTTGATTGTGATACACCCTCCGTG GACTTGGAAATGATCGATGTGCACGTTTTGGCTGACGCTTTCAAACGCTATCTCCTGGACTTACCAAATCCTGTCATTCCAGCAGCCGTT TACAGTGAAATGATTTCTTTAGCTCCAGAAGTACAAAGCTCCGAAGAATATATTCAGCTATTGAAGAAGCTTATTAGGTCGCCTAGCATA CCTCATCAGTATTGGCTTACGCTTCAGTATTTGTTAAAACATTTCTTCAAGCTCTCTCAAACCTCCAGCAAAAATCTGTTGAATGCAAGA GTACTCTCTGAAATTTTCAGCCCTATGCTTTTCAGATTCTCAGCAGCCAGCTCTGATAATACTGAAAACCTCATAAAAGTTATAGAAATT TTAATCTCAACTGAATGGAATGAACGACAGCCTGCACCAGAGATGGTGGCCACACAGCAGGAGATGATGGACGCGCAGCTGAGGCTCCAG CTGCGGGACTACTGCGCCCACCACCTCATCCGGCTGCTCAAGTGCAAGCGTGACAGCTTCCCCAACTTCCTGGCCTGCAAGCAGGAGCGG CACGACTGGGACTACTGCGAGCACCGCGACTATGTGATGCGCATGAAGGAGTTTGAGCGGGAGCGGAGGCTGCTCCAGCGGAAGAAGCGG CGGGAGAAGAAGGCGGCAGAGTTGGCCAAAGGCCAGGGACCCGGGGAAGTGGACCCCAAGGTGGCCCTGTAGGGGGTGCACCCCCCACCC >In-frame_PIK3R1_ENST00000274335_chr5_67576834_+_NDUFB7_ENST00000215565_chr19_14677745_-_1315nt TACAACCAGGCTCAACTGTTGCATGGTAGCAGATTTGCAAACATGAGTGCTGAGGGGTACCAGTACAGAGCGCTGTATGATTATAAAAAG GAAAGAGAAGAAGATATTGACTTGCACTTGGGTGACATATTGACTGTGAATAAAGGGTCCTTAGTAGCTCTTGGATTCAGTGATGGACAG GAAGCCAGGCCTGAAGAAATTGGCTGGTTAAATGGCTATAATGAAACCACAGGGGAAAGGGGGGACTTTCCGGGAACTTACGTAGAATAT ATTGGAAGGAAAAAAATCTCGCCTCCCACACCAAAGCCCCGGCCACCTCGGCCTCTTCCTGTTGCACCAGGTTCTTCGAAAACTGAAGCA GATGTTGAACAACAAGCTTTGACTCTCCCGGATCTTGCAGAGCAGTTTGCCCCTCCTGACATTGCCCCGCCTCTTCTTATCAAGCTCGTG GAAGCCATTGAAAAGAAAGGTCTGGAATGTTCAACTCTATACAGAACACAGAGCTCCAGCAACCTGGCAGAATTACGACAGCTTCTTGAT TGTGATACACCCTCCGTGGACTTGGAAATGATCGATGTGCACGTTTTGGCTGACGCTTTCAAACGCTATCTCCTGGACTTACCAAATCCT GTCATTCCAGCAGCCGTTTACAGTGAAATGATTTCTTTAGCTCCAGAAGTACAAAGCTCCGAAGAATATATTCAGCTATTGAAGAAGCTT ATTAGGTCGCCTAGCATACCTCATCAGTATTGGCTTACGCTTCAGTATTTGTTAAAACATTTCTTCAAGCTCTCTCAAACCTCCAGCAAA AATCTGTTGAATGCAAGAGTACTCTCTGAAATTTTCAGCCCTATGCTTTTCAGATTCTCAGCAGCCAGCTCTGATAATACTGAAAACCTC ATAAAAGTTATAGAAATTTTAATCTCAACTGAATGGAATGAACGACAGCCTGCACCAGAGATGGTGGCCACACAGCAGGAGATGATGGAC GCGCAGCTGAGGCTCCAGCTGCGGGACTACTGCGCCCACCACCTCATCCGGCTGCTCAAGTGCAAGCGTGACAGCTTCCCCAACTTCCTG GCCTGCAAGCAGGAGCGGCACGACTGGGACTACTGCGAGCACCGCGACTATGTGATGCGCATGAAGGAGTTTGAGCGGGAGCGGAGGCTG CTCCAGCGGAAGAAGCGGCGGGAGAAGAAGGCGGCAGAGTTGGCCAAAGGCCAGGGACCCGGGGAAGTGGACCCCAAGGTGGCCCTGTAG >In-frame_PIK3R1_ENST00000396611_chr5_67576834_+_NDUFB7_ENST00000215565_chr19_14677745_-_1315nt TACAACCAGGCTCAACTGTTGCATGGTAGCAGATTTGCAAACATGAGTGCTGAGGGGTACCAGTACAGAGCGCTGTATGATTATAAAAAG GAAAGAGAAGAAGATATTGACTTGCACTTGGGTGACATATTGACTGTGAATAAAGGGTCCTTAGTAGCTCTTGGATTCAGTGATGGACAG GAAGCCAGGCCTGAAGAAATTGGCTGGTTAAATGGCTATAATGAAACCACAGGGGAAAGGGGGGACTTTCCGGGAACTTACGTAGAATAT ATTGGAAGGAAAAAAATCTCGCCTCCCACACCAAAGCCCCGGCCACCTCGGCCTCTTCCTGTTGCACCAGGTTCTTCGAAAACTGAAGCA GATGTTGAACAACAAGCTTTGACTCTCCCGGATCTTGCAGAGCAGTTTGCCCCTCCTGACATTGCCCCGCCTCTTCTTATCAAGCTCGTG GAAGCCATTGAAAAGAAAGGTCTGGAATGTTCAACTCTATACAGAACACAGAGCTCCAGCAACCTGGCAGAATTACGACAGCTTCTTGAT TGTGATACACCCTCCGTGGACTTGGAAATGATCGATGTGCACGTTTTGGCTGACGCTTTCAAACGCTATCTCCTGGACTTACCAAATCCT GTCATTCCAGCAGCCGTTTACAGTGAAATGATTTCTTTAGCTCCAGAAGTACAAAGCTCCGAAGAATATATTCAGCTATTGAAGAAGCTT ATTAGGTCGCCTAGCATACCTCATCAGTATTGGCTTACGCTTCAGTATTTGTTAAAACATTTCTTCAAGCTCTCTCAAACCTCCAGCAAA AATCTGTTGAATGCAAGAGTACTCTCTGAAATTTTCAGCCCTATGCTTTTCAGATTCTCAGCAGCCAGCTCTGATAATACTGAAAACCTC ATAAAAGTTATAGAAATTTTAATCTCAACTGAATGGAATGAACGACAGCCTGCACCAGAGATGGTGGCCACACAGCAGGAGATGATGGAC GCGCAGCTGAGGCTCCAGCTGCGGGACTACTGCGCCCACCACCTCATCCGGCTGCTCAAGTGCAAGCGTGACAGCTTCCCCAACTTCCTG GCCTGCAAGCAGGAGCGGCACGACTGGGACTACTGCGAGCACCGCGACTATGTGATGCGCATGAAGGAGTTTGAGCGGGAGCGGAGGCTG CTCCAGCGGAAGAAGCGGCGGGAGAAGAAGGCGGCAGAGTTGGCCAAAGGCCAGGGACCCGGGGAAGTGGACCCCAAGGTGGCCCTGTAG |
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FusionGenePPI for PIK3R1_NDUFB7 |
| Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in . |
| Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160) |
| Hgene | Hgene's interactors | Tgene | Tgene's interactors |
| PIK3R1 | LCP2, CTNNB1, SRC, ABL1, FYN, LCK, PIK3R1, SHC1, GNAQ, WAS, IRS2, FCGR2A, VAV1, GAB1, IRS1, PIK3CA, RRAS2, KIT, AXL, DOK1, EPOR, KHDRBS1, CBLB, IL1R1, EZR, BCAR1, CD28, LAT, PIK3CD, GRB2, ERBB3, PTPN6, CD3E, EPHA2, ARHGAP17, ARAF, IFNAR1, TYRO3, ARHGAP32, CSF2RA, NFKBIA, GAB2, TUBA1B, TGFBR1, TGFBR2, HRAS, PTK2, AGAP2, PECAM1, CBL, CRKL, CD7, ARHGAP1, FES, SH3KBP1, PTPN11, INPP5D, PIK3CB, ADAM12, IL6ST, HCST, ESR1, SHB, NTRK2, SYN1, PDGFRB, LTK, FGFR2, NPM1, SOCS6, PXK, YWHAG, EGFR, ADAMTS2, CXCL2, CYP4A11, TTR, HDAC3, ITSN1, SYNM, RAB5A, ERBB2, CRK, NCK1, CSF1R, SYK, ZAP70, FLT3, PDGFRA, CUL3, GRB10, BRCA1, JAK2, ALK, SELPLG, TNIP1, CMIP, INPPL1, PIK3R2, EP300, HTT, MED28, ABI1, APPL1, TNFRSF1A, FBXL2, TLR3, DAB2IP, MAP3K5, DLX2, GSPT1, HOXA1, CCL14, CD40, ALOX5, EPN1, IRS4, NCL, ZDHHC17, SQSTM1, SIRT1, EFNB2, CD244, VSIG4, PRMT2, PTGER3, PCBP1, NTRK1, CLNK, SH2D2A, SOCS1, STAT3, TNS4, FER, PDE4D, TMEM17, CHAF1A, NYAP2, FASLG, FGFR1, IGF1R, PLCG2, SOS1, PXN, RXRA, FLT1, RASD2, DNM2, CD247, KBTBD2, WEE1, VHL, MAPT, AKT1, GNB1, ACTA1, BCR, PTPRK, FLRT1, PIK3R3, DEFA5, RNF19B, SNX32, NLGN3, HAVCR2, IL20RA, PROM1, NYAP1, MYO16, FAS, NISCH, PTTG1, WDR26 | NDUFB7 | NDUFA2, NDUFB10, UQCRQ, MPV17, TOMM7, CD55, ZMPSTE24, HSPA1L, LAMTOR3, ICT1, CAPN1, MAK, CKAP4, MLKL, NDUFA8, ATP5F1, ATP6V0D1, COX4I1, NDUFA10, ATP1B3, VDAC3, NDUFB9, PHB2, UQCRC2, NDUFA12, NDUFS3, NDUFS5, NDUFA9, RAB5C, RAB7A, GOLT1B, MMGT1, NDUFA4, NDUFB11, NDUFS6, NDUFB5, NDUFS7 |
| - Retained PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
| - Lost PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
| - Retained PPIs, but lost function due to frame-shift fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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RelatedDrugs for PIK3R1_NDUFB7 |
| Drugs targeting genes involved in this fusion gene. (DrugBank Version 5.1.0 2018-04-02) |
| Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
| Hgene | PIK3R1 | P27986 | DB01064 | Isoprenaline | Phosphatidylinositol 3-kinase regulatory subunit alpha | small molecule | approved|investigational |
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RelatedDiseases for PIK3R1_NDUFB7 |
| Diseases associated with fusion partners. (DisGeNet 4.0) |
| Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
| Hgene | PIK3R1 | C0001973 | Alcoholic Intoxication, Chronic | 2 | PSYGENET |
| Hgene | PIK3R1 | C0878684 | SHORT syndrome | 2 | ORPHANET;UNIPROT |
| Hgene | PIK3R1 | C0006413 | Burkitt Lymphoma | 1 | CTD_human |
| Hgene | PIK3R1 | C0021655 | Insulin Resistance | 1 | CTD_human |
| Hgene | PIK3R1 | C0024667 | Animal Mammary Neoplasms | 1 | CTD_human |
| Hgene | PIK3R1 | C0024668 | Mammary Neoplasms, Experimental | 1 | CTD_human |
| Tgene | NDUFB7 | C0019202 | Hepatolenticular Degeneration | 1 | CTD_human |
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