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Fusion gene ID: 27204 |
FusionGeneSummary for PIK3R1_GINS3 |
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Fusion gene information | Fusion gene name: PIK3R1_GINS3 | Fusion gene ID: 27204 | Hgene | Tgene | Gene symbol | PIK3R1 | GINS3 | Gene ID | 5295 | 64785 |
Gene name | phosphoinositide-3-kinase regulatory subunit 1 | GINS complex subunit 3 | |
Synonyms | AGM7|GRB1|IMD36|p85|p85-ALPHA | PSF3 | |
Cytomap | 5q13.1 | 16q21 | |
Type of gene | protein-coding | protein-coding | |
Description | phosphatidylinositol 3-kinase regulatory subunit alphaPI3-kinase subunit p85-alphaPI3K regulatory subunit alphaphosphatidylinositol 3-kinase 85 kDa regulatory subunit alphaphosphatidylinositol 3-kinase, regulatory subunit, polypeptide 1 (p85 alpha)ph | DNA replication complex GINS protein PSF3GINS complex subunit 3 (Psf3 homolog) | |
Modification date | 20180523 | 20180519 | |
UniProtAcc | P27986 | Q9BRX5 | |
Ensembl transtripts involved in fusion gene | ENST00000521381, ENST00000521657, ENST00000517643, ENST00000274335, ENST00000396611, ENST00000320694, ENST00000336483, ENST00000523872, | ENST00000561952, ENST00000426538, ENST00000328514, ENST00000318129, | |
Fusion gene scores | * DoF score | 5 X 3 X 5=75 | 1 X 1 X 1=1 |
# samples | 5 | 1 | |
** MAII score | log2(5/75*10)=-0.584962500721156 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | log2(1/1*10)=3.32192809488736 | |
Context | PubMed: PIK3R1 [Title/Abstract] AND GINS3 [Title/Abstract] AND fusion [Title/Abstract] | ||
Functional or gene categories assigned by FusionGDB annotation |
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
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Partner | Gene | GO ID | GO term | PubMed ID |
Hgene | PIK3R1 | GO:0014065 | phosphatidylinositol 3-kinase signaling | 7782332 |
Hgene | PIK3R1 | GO:0034976 | response to endoplasmic reticulum stress | 20348923 |
Hgene | PIK3R1 | GO:0042307 | positive regulation of protein import into nucleus | 20348923 |
Hgene | PIK3R1 | GO:0048009 | insulin-like growth factor receptor signaling pathway | 7782332 |
Hgene | PIK3R1 | GO:0050821 | protein stabilization | 20348923 |
Hgene | PIK3R1 | GO:0060396 | growth hormone receptor signaling pathway | 7782332 |
![]() (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
TCGA | LD | PCPG | TCGA-W2-A7HB-01A | PIK3R1 | chr5 | 67522837 | + | GINS3 | chr16 | 58420525 | + |
* LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
![]() * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
5CDS-3UTR | ENST00000521381 | ENST00000561952 | PIK3R1 | chr5 | 67522837 | + | GINS3 | chr16 | 58420525 | + |
5CDS-intron | ENST00000521381 | ENST00000426538 | PIK3R1 | chr5 | 67522837 | + | GINS3 | chr16 | 58420525 | + |
5CDS-intron | ENST00000521381 | ENST00000328514 | PIK3R1 | chr5 | 67522837 | + | GINS3 | chr16 | 58420525 | + |
5CDS-intron | ENST00000521381 | ENST00000318129 | PIK3R1 | chr5 | 67522837 | + | GINS3 | chr16 | 58420525 | + |
5CDS-3UTR | ENST00000521657 | ENST00000561952 | PIK3R1 | chr5 | 67522837 | + | GINS3 | chr16 | 58420525 | + |
5CDS-intron | ENST00000521657 | ENST00000426538 | PIK3R1 | chr5 | 67522837 | + | GINS3 | chr16 | 58420525 | + |
5CDS-intron | ENST00000521657 | ENST00000328514 | PIK3R1 | chr5 | 67522837 | + | GINS3 | chr16 | 58420525 | + |
5CDS-intron | ENST00000521657 | ENST00000318129 | PIK3R1 | chr5 | 67522837 | + | GINS3 | chr16 | 58420525 | + |
intron-3UTR | ENST00000517643 | ENST00000561952 | PIK3R1 | chr5 | 67522837 | + | GINS3 | chr16 | 58420525 | + |
intron-intron | ENST00000517643 | ENST00000426538 | PIK3R1 | chr5 | 67522837 | + | GINS3 | chr16 | 58420525 | + |
intron-intron | ENST00000517643 | ENST00000328514 | PIK3R1 | chr5 | 67522837 | + | GINS3 | chr16 | 58420525 | + |
intron-intron | ENST00000517643 | ENST00000318129 | PIK3R1 | chr5 | 67522837 | + | GINS3 | chr16 | 58420525 | + |
5CDS-3UTR | ENST00000274335 | ENST00000561952 | PIK3R1 | chr5 | 67522837 | + | GINS3 | chr16 | 58420525 | + |
5CDS-intron | ENST00000274335 | ENST00000426538 | PIK3R1 | chr5 | 67522837 | + | GINS3 | chr16 | 58420525 | + |
5CDS-intron | ENST00000274335 | ENST00000328514 | PIK3R1 | chr5 | 67522837 | + | GINS3 | chr16 | 58420525 | + |
5CDS-intron | ENST00000274335 | ENST00000318129 | PIK3R1 | chr5 | 67522837 | + | GINS3 | chr16 | 58420525 | + |
5CDS-3UTR | ENST00000396611 | ENST00000561952 | PIK3R1 | chr5 | 67522837 | + | GINS3 | chr16 | 58420525 | + |
5CDS-intron | ENST00000396611 | ENST00000426538 | PIK3R1 | chr5 | 67522837 | + | GINS3 | chr16 | 58420525 | + |
5CDS-intron | ENST00000396611 | ENST00000328514 | PIK3R1 | chr5 | 67522837 | + | GINS3 | chr16 | 58420525 | + |
5CDS-intron | ENST00000396611 | ENST00000318129 | PIK3R1 | chr5 | 67522837 | + | GINS3 | chr16 | 58420525 | + |
intron-3UTR | ENST00000320694 | ENST00000561952 | PIK3R1 | chr5 | 67522837 | + | GINS3 | chr16 | 58420525 | + |
intron-intron | ENST00000320694 | ENST00000426538 | PIK3R1 | chr5 | 67522837 | + | GINS3 | chr16 | 58420525 | + |
intron-intron | ENST00000320694 | ENST00000328514 | PIK3R1 | chr5 | 67522837 | + | GINS3 | chr16 | 58420525 | + |
intron-intron | ENST00000320694 | ENST00000318129 | PIK3R1 | chr5 | 67522837 | + | GINS3 | chr16 | 58420525 | + |
intron-3UTR | ENST00000336483 | ENST00000561952 | PIK3R1 | chr5 | 67522837 | + | GINS3 | chr16 | 58420525 | + |
intron-intron | ENST00000336483 | ENST00000426538 | PIK3R1 | chr5 | 67522837 | + | GINS3 | chr16 | 58420525 | + |
intron-intron | ENST00000336483 | ENST00000328514 | PIK3R1 | chr5 | 67522837 | + | GINS3 | chr16 | 58420525 | + |
intron-intron | ENST00000336483 | ENST00000318129 | PIK3R1 | chr5 | 67522837 | + | GINS3 | chr16 | 58420525 | + |
intron-3UTR | ENST00000523872 | ENST00000561952 | PIK3R1 | chr5 | 67522837 | + | GINS3 | chr16 | 58420525 | + |
intron-intron | ENST00000523872 | ENST00000426538 | PIK3R1 | chr5 | 67522837 | + | GINS3 | chr16 | 58420525 | + |
intron-intron | ENST00000523872 | ENST00000328514 | PIK3R1 | chr5 | 67522837 | + | GINS3 | chr16 | 58420525 | + |
intron-intron | ENST00000523872 | ENST00000318129 | PIK3R1 | chr5 | 67522837 | + | GINS3 | chr16 | 58420525 | + |
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FusionProtFeatures for PIK3R1_GINS3 |
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Hgene | Tgene |
PIK3R1 | GINS3 |
The GINS complex plays an essential role in theinitiation of DNA replication, and progression of DNA replicationforks. GINS complex seems to bind preferentially to single-stranded DNA. {ECO:0000269|PubMed:17417653}. |
![]() * Minus value of BPloci means that the break pointn is located before the CDS. |
- In-frame and retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
- In-frame and not-retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
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FusionGeneSequence for PIK3R1_GINS3 |
![]() (nt: nucleotides, aa: amino acids) |
* Fusion amino acid sequences. |
* Fusion transcript sequences (only coding sequence (CDS) region). |
* Fusion transcript sequences (Full-length transcript). |
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FusionGenePPI for PIK3R1_GINS3 |
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Hgene | Hgene's interactors | Tgene | Tgene's interactors |
PIK3R1 | LCP2, CTNNB1, SRC, ABL1, FYN, LCK, PIK3R1, SHC1, GNAQ, WAS, IRS2, FCGR2A, VAV1, GAB1, IRS1, PIK3CA, RRAS2, KIT, AXL, DOK1, EPOR, KHDRBS1, CBLB, IL1R1, EZR, BCAR1, CD28, LAT, PIK3CD, GRB2, ERBB3, PTPN6, CD3E, EPHA2, ARHGAP17, ARAF, IFNAR1, TYRO3, ARHGAP32, CSF2RA, NFKBIA, GAB2, TUBA1B, TGFBR1, TGFBR2, HRAS, PTK2, AGAP2, PECAM1, CBL, CRKL, CD7, ARHGAP1, FES, SH3KBP1, PTPN11, INPP5D, PIK3CB, ADAM12, IL6ST, HCST, ESR1, SHB, NTRK2, SYN1, PDGFRB, LTK, FGFR2, NPM1, SOCS6, PXK, YWHAG, EGFR, ADAMTS2, CXCL2, CYP4A11, TTR, HDAC3, ITSN1, SYNM, RAB5A, ERBB2, CRK, NCK1, CSF1R, SYK, ZAP70, FLT3, PDGFRA, CUL3, GRB10, BRCA1, JAK2, ALK, SELPLG, TNIP1, CMIP, INPPL1, PIK3R2, EP300, HTT, MED28, ABI1, APPL1, TNFRSF1A, FBXL2, TLR3, DAB2IP, MAP3K5, DLX2, GSPT1, HOXA1, CCL14, CD40, ALOX5, EPN1, IRS4, NCL, ZDHHC17, SQSTM1, SIRT1, EFNB2, CD244, VSIG4, PRMT2, PTGER3, PCBP1, NTRK1, CLNK, SH2D2A, SOCS1, STAT3, TNS4, FER, PDE4D, TMEM17, CHAF1A, NYAP2, FASLG, FGFR1, IGF1R, PLCG2, SOS1, PXN, RXRA, FLT1, RASD2, DNM2, CD247, KBTBD2, WEE1, VHL, MAPT, AKT1, GNB1, ACTA1, BCR, PTPRK, FLRT1, PIK3R3, DEFA5, RNF19B, SNX32, NLGN3, HAVCR2, IL20RA, PROM1, NYAP1, MYO16, FAS, NISCH, PTTG1, WDR26 | GINS3 | GINS4, GINS1, GINS2, CD2BP2, IGBP1, CPLX1, ABHD14A, BZW2, CAPN1, CSE1L, CTPS1, DCPS, ECHS1, EIF6, GDI1, GSS, HSPA9, MSN, PAFAH1B2, PFAS, PPP5C, RAP1GDS1, VCL, MCM7, TIMELESS, MCM2, CLSPN, TIPIN, RFC2, WDHD1, ZC3H15, CSNK1G2, SSRP1, GTF2E2, H2AFX, HIST1H2BA |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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RelatedDrugs for PIK3R1_GINS3 |
![]() (DrugBank Version 5.1.0 2018-04-02) |
Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
Hgene | PIK3R1 | P27986 | DB01064 | Isoprenaline | Phosphatidylinositol 3-kinase regulatory subunit alpha | small molecule | approved|investigational |
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RelatedDiseases for PIK3R1_GINS3 |
![]() (DisGeNet 4.0) |
Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
Hgene | PIK3R1 | C0001973 | Alcoholic Intoxication, Chronic | 2 | PSYGENET |
Hgene | PIK3R1 | C0878684 | SHORT syndrome | 2 | ORPHANET;UNIPROT |
Hgene | PIK3R1 | C0006413 | Burkitt Lymphoma | 1 | CTD_human |
Hgene | PIK3R1 | C0021655 | Insulin Resistance | 1 | CTD_human |
Hgene | PIK3R1 | C0024667 | Animal Mammary Neoplasms | 1 | CTD_human |
Hgene | PIK3R1 | C0024668 | Mammary Neoplasms, Experimental | 1 | CTD_human |