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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 272

FusionGeneSummary for ABLIM1_PTCD2

check button Fusion gene summary
Fusion gene informationFusion gene name: ABLIM1_PTCD2
Fusion gene ID: 272
HgeneTgene
Gene symbol

ABLIM1

PTCD2

Gene ID

3983

79810

Gene nameactin binding LIM protein 1pentatricopeptide repeat domain 2
SynonymsABLIM|LIMAB1|LIMATIN|abLIM-1-
Cytomap

10q25.3

5q13.2

Type of geneprotein-codingprotein-coding
Descriptionactin-binding LIM protein 1actin-binding LIM protein family member 1actin-binding double-zinc-finger proteinpentatricopeptide repeat-containing protein 2, mitochondrialCTC-365E16.1
Modification date2018052320180519
UniProtAcc

O14639

Q8WV60

Ensembl transtripts involved in fusion geneENST00000369252, ENST00000533213, 
ENST00000277895, ENST00000369266, 
ENST00000392952, ENST00000369253, 
ENST00000477638, 		ENST00000380639, 
ENST00000543322, ENST00000503868, 
ENST00000536805, ENST00000460837, 
Fusion gene scores* DoF score7 X 7 X 3=1472 X 2 X 2=8
# samples 72
** MAII scorelog2(7/147*10)=-1.0703893278914
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(2/8*10)=1.32192809488736
Context

PubMed: ABLIM1 [Title/Abstract] AND PTCD2 [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID

check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
TCGARVBRCATCGA-AO-A12G-01AABLIM1chr10

116203788

-PTCD2chr5

71630845

+
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
Frame-shiftENST00000369252ENST00000380639ABLIM1chr10

116203788

-PTCD2chr5

71630845

+
5CDS-intronENST00000369252ENST00000543322ABLIM1chr10

116203788

-PTCD2chr5

71630845

+
5CDS-intronENST00000369252ENST00000503868ABLIM1chr10

116203788

-PTCD2chr5

71630845

+
5CDS-intronENST00000369252ENST00000536805ABLIM1chr10

116203788

-PTCD2chr5

71630845

+
5CDS-intronENST00000369252ENST00000460837ABLIM1chr10

116203788

-PTCD2chr5

71630845

+
Frame-shiftENST00000533213ENST00000380639ABLIM1chr10

116203788

-PTCD2chr5

71630845

+
5CDS-intronENST00000533213ENST00000543322ABLIM1chr10

116203788

-PTCD2chr5

71630845

+
5CDS-intronENST00000533213ENST00000503868ABLIM1chr10

116203788

-PTCD2chr5

71630845

+
5CDS-intronENST00000533213ENST00000536805ABLIM1chr10

116203788

-PTCD2chr5

71630845

+
5CDS-intronENST00000533213ENST00000460837ABLIM1chr10

116203788

-PTCD2chr5

71630845

+
Frame-shiftENST00000277895ENST00000380639ABLIM1chr10

116203788

-PTCD2chr5

71630845

+
5CDS-intronENST00000277895ENST00000543322ABLIM1chr10

116203788

-PTCD2chr5

71630845

+
5CDS-intronENST00000277895ENST00000503868ABLIM1chr10

116203788

-PTCD2chr5

71630845

+
5CDS-intronENST00000277895ENST00000536805ABLIM1chr10

116203788

-PTCD2chr5

71630845

+
5CDS-intronENST00000277895ENST00000460837ABLIM1chr10

116203788

-PTCD2chr5

71630845

+
Frame-shiftENST00000369266ENST00000380639ABLIM1chr10

116203788

-PTCD2chr5

71630845

+
5CDS-intronENST00000369266ENST00000543322ABLIM1chr10

116203788

-PTCD2chr5

71630845

+
5CDS-intronENST00000369266ENST00000503868ABLIM1chr10

116203788

-PTCD2chr5

71630845

+
5CDS-intronENST00000369266ENST00000536805ABLIM1chr10

116203788

-PTCD2chr5

71630845

+
5CDS-intronENST00000369266ENST00000460837ABLIM1chr10

116203788

-PTCD2chr5

71630845

+
Frame-shiftENST00000392952ENST00000380639ABLIM1chr10

116203788

-PTCD2chr5

71630845

+
5CDS-intronENST00000392952ENST00000543322ABLIM1chr10

116203788

-PTCD2chr5

71630845

+
5CDS-intronENST00000392952ENST00000503868ABLIM1chr10

116203788

-PTCD2chr5

71630845

+
5CDS-intronENST00000392952ENST00000536805ABLIM1chr10

116203788

-PTCD2chr5

71630845

+
5CDS-intronENST00000392952ENST00000460837ABLIM1chr10

116203788

-PTCD2chr5

71630845

+
Frame-shiftENST00000369253ENST00000380639ABLIM1chr10

116203788

-PTCD2chr5

71630845

+
5CDS-intronENST00000369253ENST00000543322ABLIM1chr10

116203788

-PTCD2chr5

71630845

+
5CDS-intronENST00000369253ENST00000503868ABLIM1chr10

116203788

-PTCD2chr5

71630845

+
5CDS-intronENST00000369253ENST00000536805ABLIM1chr10

116203788

-PTCD2chr5

71630845

+
5CDS-intronENST00000369253ENST00000460837ABLIM1chr10

116203788

-PTCD2chr5

71630845

+
intron-3CDSENST00000477638ENST00000380639ABLIM1chr10

116203788

-PTCD2chr5

71630845

+
intron-intronENST00000477638ENST00000543322ABLIM1chr10

116203788

-PTCD2chr5

71630845

+
intron-intronENST00000477638ENST00000503868ABLIM1chr10

116203788

-PTCD2chr5

71630845

+
intron-intronENST00000477638ENST00000536805ABLIM1chr10

116203788

-PTCD2chr5

71630845

+
intron-intronENST00000477638ENST00000460837ABLIM1chr10

116203788

-PTCD2chr5

71630845

+

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FusionProtFeatures for ABLIM1_PTCD2


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
ABLIM1

O14639

PTCD2

Q8WV60

Involved in mitochondrial RNA maturation andmitochondrial respiratory chain function. {ECO:0000250}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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FusionGeneSequence for ABLIM1_PTCD2


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for ABLIM1_PTCD2


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors
ABLIM1VIM, GOLGA2, BEGAIN, TRAF2, LDOC1, TSC22D4, USHBP1, CALCOCO2, HOOK2, KRT15, SFN, KCNJ12, SREBF2, ACTB, APP, ABRA, YWHAE, YWHAB, ASB18, CARD9, CCDC8, SUZ12, CASK, LUZP4, ABCE1, NMT1, SEPSECS, LIN7C, KIAA0753, SSX2IP, CEP128, CEP89, FBF1, NINL, ODF2, SCLT1, CEP19, STIL, CENPJ, XPO1, CAPZA2, CDK2, DBN1, FLNA, MYH9, MYO1C, PPP1CB, IQGAP1, PDLIM7, SYNPO, MAPRE1, LIMA1, ANLN, MYO19, MYO18A, CDH1, CYB5D2, KLHL40, BCO1, MED21, YWHAZ, CBY1, CYLD, TRIM25PTCD2MID2, TRIM32, MOV10, NXF1, SLAMF7, SLAMF1, HLA-E, VSIG4, GTF2A1, VTN, SALL2, NTRK3, CDH8, CLEC14A, APP, LRP1


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for ABLIM1_PTCD2


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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RelatedDiseases for ABLIM1_PTCD2


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
HgeneABLIM1C0236969Substance-Related Disorders1CTD_human