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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 27154

FusionGeneSummary for PIGT_CTNNA2

check button Fusion gene summary
Fusion gene informationFusion gene name: PIGT_CTNNA2
Fusion gene ID: 27154
HgeneTgene
Gene symbol

PIGT

CTNNA2

Gene ID

51604

1496

Gene namephosphatidylinositol glycan anchor biosynthesis class Tcatenin alpha 2
SynonymsCGI-06|MCAHS3|NDAP|PNH2CAP-R|CAPR|CT114|CTNR
Cytomap

20q13.12

2p12

Type of geneprotein-codingprotein-coding
DescriptionGPI transamidase component PIG-TGPI transamidase subunitneurotrophin-regulated neuronal development-associated proteinphosphatidylinositol-glycan biosynthesis class T proteincatenin alpha-2alpha-N-cateninalpha-catenin-related proteincadherin-associated protein, relatedcancer/testis antigen 114catenin (cadherin-associated protein), alpha 2
Modification date2018052320180522
UniProtAcc

Q969N2

P26232

Ensembl transtripts involved in fusion geneENST00000279036, ENST00000279035, 
ENST00000372689, ENST00000545755, 
ENST00000535404, ENST00000341555, 
ENST00000543458, 
ENST00000466387, 
ENST00000496558, ENST00000361291, 
ENST00000402739, ENST00000540488, 
ENST00000541047, ENST00000343114, 
ENST00000496251, ENST00000409266, 
Fusion gene scores* DoF score4 X 4 X 2=3215 X 12 X 9=1620
# samples 415
** MAII scorelog2(4/32*10)=0.321928094887362
effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs).
DoF>8 and MAII>0
log2(15/1620*10)=-3.43295940727611
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: PIGT [Title/Abstract] AND CTNNA2 [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID

check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChiTaRS3.1BE938441PIGTchr20

44048017

+CTNNA2chr2

80392188

-
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
5CDS-intronENST00000279036ENST00000466387PIGTchr20

44048017

+CTNNA2chr2

80392188

-
5CDS-intronENST00000279036ENST00000496558PIGTchr20

44048017

+CTNNA2chr2

80392188

-
5CDS-intronENST00000279036ENST00000361291PIGTchr20

44048017

+CTNNA2chr2

80392188

-
5CDS-intronENST00000279036ENST00000402739PIGTchr20

44048017

+CTNNA2chr2

80392188

-
5CDS-intronENST00000279036ENST00000540488PIGTchr20

44048017

+CTNNA2chr2

80392188

-
5CDS-intronENST00000279036ENST00000541047PIGTchr20

44048017

+CTNNA2chr2

80392188

-
5CDS-intronENST00000279036ENST00000343114PIGTchr20

44048017

+CTNNA2chr2

80392188

-
5CDS-intronENST00000279036ENST00000496251PIGTchr20

44048017

+CTNNA2chr2

80392188

-
5CDS-intronENST00000279036ENST00000409266PIGTchr20

44048017

+CTNNA2chr2

80392188

-
5CDS-intronENST00000279035ENST00000466387PIGTchr20

44048017

+CTNNA2chr2

80392188

-
5CDS-intronENST00000279035ENST00000496558PIGTchr20

44048017

+CTNNA2chr2

80392188

-
5CDS-intronENST00000279035ENST00000361291PIGTchr20

44048017

+CTNNA2chr2

80392188

-
5CDS-intronENST00000279035ENST00000402739PIGTchr20

44048017

+CTNNA2chr2

80392188

-
5CDS-intronENST00000279035ENST00000540488PIGTchr20

44048017

+CTNNA2chr2

80392188

-
5CDS-intronENST00000279035ENST00000541047PIGTchr20

44048017

+CTNNA2chr2

80392188

-
5CDS-intronENST00000279035ENST00000343114PIGTchr20

44048017

+CTNNA2chr2

80392188

-
5CDS-intronENST00000279035ENST00000496251PIGTchr20

44048017

+CTNNA2chr2

80392188

-
5CDS-intronENST00000279035ENST00000409266PIGTchr20

44048017

+CTNNA2chr2

80392188

-
5CDS-intronENST00000372689ENST00000466387PIGTchr20

44048017

+CTNNA2chr2

80392188

-
5CDS-intronENST00000372689ENST00000496558PIGTchr20

44048017

+CTNNA2chr2

80392188

-
5CDS-intronENST00000372689ENST00000361291PIGTchr20

44048017

+CTNNA2chr2

80392188

-
5CDS-intronENST00000372689ENST00000402739PIGTchr20

44048017

+CTNNA2chr2

80392188

-
5CDS-intronENST00000372689ENST00000540488PIGTchr20

44048017

+CTNNA2chr2

80392188

-
5CDS-intronENST00000372689ENST00000541047PIGTchr20

44048017

+CTNNA2chr2

80392188

-
5CDS-intronENST00000372689ENST00000343114PIGTchr20

44048017

+CTNNA2chr2

80392188

-
5CDS-intronENST00000372689ENST00000496251PIGTchr20

44048017

+CTNNA2chr2

80392188

-
5CDS-intronENST00000372689ENST00000409266PIGTchr20

44048017

+CTNNA2chr2

80392188

-
intron-intronENST00000545755ENST00000466387PIGTchr20

44048017

+CTNNA2chr2

80392188

-
intron-intronENST00000545755ENST00000496558PIGTchr20

44048017

+CTNNA2chr2

80392188

-
intron-intronENST00000545755ENST00000361291PIGTchr20

44048017

+CTNNA2chr2

80392188

-
intron-intronENST00000545755ENST00000402739PIGTchr20

44048017

+CTNNA2chr2

80392188

-
intron-intronENST00000545755ENST00000540488PIGTchr20

44048017

+CTNNA2chr2

80392188

-
intron-intronENST00000545755ENST00000541047PIGTchr20

44048017

+CTNNA2chr2

80392188

-
intron-intronENST00000545755ENST00000343114PIGTchr20

44048017

+CTNNA2chr2

80392188

-
intron-intronENST00000545755ENST00000496251PIGTchr20

44048017

+CTNNA2chr2

80392188

-
intron-intronENST00000545755ENST00000409266PIGTchr20

44048017

+CTNNA2chr2

80392188

-
intron-intronENST00000535404ENST00000466387PIGTchr20

44048017

+CTNNA2chr2

80392188

-
intron-intronENST00000535404ENST00000496558PIGTchr20

44048017

+CTNNA2chr2

80392188

-
intron-intronENST00000535404ENST00000361291PIGTchr20

44048017

+CTNNA2chr2

80392188

-
intron-intronENST00000535404ENST00000402739PIGTchr20

44048017

+CTNNA2chr2

80392188

-
intron-intronENST00000535404ENST00000540488PIGTchr20

44048017

+CTNNA2chr2

80392188

-
intron-intronENST00000535404ENST00000541047PIGTchr20

44048017

+CTNNA2chr2

80392188

-
intron-intronENST00000535404ENST00000343114PIGTchr20

44048017

+CTNNA2chr2

80392188

-
intron-intronENST00000535404ENST00000496251PIGTchr20

44048017

+CTNNA2chr2

80392188

-
intron-intronENST00000535404ENST00000409266PIGTchr20

44048017

+CTNNA2chr2

80392188

-
intron-intronENST00000341555ENST00000466387PIGTchr20

44048017

+CTNNA2chr2

80392188

-
intron-intronENST00000341555ENST00000496558PIGTchr20

44048017

+CTNNA2chr2

80392188

-
intron-intronENST00000341555ENST00000361291PIGTchr20

44048017

+CTNNA2chr2

80392188

-
intron-intronENST00000341555ENST00000402739PIGTchr20

44048017

+CTNNA2chr2

80392188

-
intron-intronENST00000341555ENST00000540488PIGTchr20

44048017

+CTNNA2chr2

80392188

-
intron-intronENST00000341555ENST00000541047PIGTchr20

44048017

+CTNNA2chr2

80392188

-
intron-intronENST00000341555ENST00000343114PIGTchr20

44048017

+CTNNA2chr2

80392188

-
intron-intronENST00000341555ENST00000496251PIGTchr20

44048017

+CTNNA2chr2

80392188

-
intron-intronENST00000341555ENST00000409266PIGTchr20

44048017

+CTNNA2chr2

80392188

-
5CDS-intronENST00000543458ENST00000466387PIGTchr20

44048017

+CTNNA2chr2

80392188

-
5CDS-intronENST00000543458ENST00000496558PIGTchr20

44048017

+CTNNA2chr2

80392188

-
5CDS-intronENST00000543458ENST00000361291PIGTchr20

44048017

+CTNNA2chr2

80392188

-
5CDS-intronENST00000543458ENST00000402739PIGTchr20

44048017

+CTNNA2chr2

80392188

-
5CDS-intronENST00000543458ENST00000540488PIGTchr20

44048017

+CTNNA2chr2

80392188

-
5CDS-intronENST00000543458ENST00000541047PIGTchr20

44048017

+CTNNA2chr2

80392188

-
5CDS-intronENST00000543458ENST00000343114PIGTchr20

44048017

+CTNNA2chr2

80392188

-
5CDS-intronENST00000543458ENST00000496251PIGTchr20

44048017

+CTNNA2chr2

80392188

-
5CDS-intronENST00000543458ENST00000409266PIGTchr20

44048017

+CTNNA2chr2

80392188

-

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FusionProtFeatures for PIGT_CTNNA2


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
PIGT

Q969N2

CTNNA2

P26232


check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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FusionGeneSequence for PIGT_CTNNA2


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for PIGT_CTNNA2


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for PIGT_CTNNA2


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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RelatedDiseases for PIGT_CTNNA2


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
HgenePIGTC0019050Hemoglobinuria, Paroxysmal1CTD_human
HgenePIGTC3809356MULTIPLE CONGENITAL ANOMALIES-HYPOTONIA-SEIZURES SYNDROME 31ORPHANET;UNIPROT
TgeneCTNNA2C0001973Alcoholic Intoxication, Chronic1PSYGENET
TgeneCTNNA2C0036341Schizophrenia1PSYGENET
TgeneCTNNA2C0038356Stomach Neoplasms1CTD_human